Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	astrocyte end-foot	ADCY10 ADGRG1	2.82e-04	12	44	2	GO:0097450
MousePheno	increased central memory CD8 positive, alpha-beta T cell number	RAG1 CD8B CD8B2	9.70e-05	35	36	3	MP:0010847
MousePheno	abnormal CD8-positive, alpha-beta T cell differentiation	RAG1 CD8B CD8B2	1.15e-04	37	36	3	MP:0008080
MousePheno	abnormal central memory CD8-positive, alpha-beta T cell number	RAG1 CD8B CD8B2	1.68e-04	42	36	3	MP:0012772
MousePheno	abnormal central memory CD8 positive, alpha-beta T cell morphology	RAG1 CD8B CD8B2	1.68e-04	42	36	3	MP:0010846
Domain	GUANYLATE_KINASE_2	MAGI1 DLG5	1.27e-03	23	43	2	PS50052
Domain	GUANYLATE_KINASE_1	MAGI1 DLG5	1.27e-03	23	43	2	PS00856
Domain	Guanylate_kin	MAGI1 DLG5	1.62e-03	26	43	2	PF00625
Domain	GK/Ca_channel_bsu	MAGI1 DLG5	1.62e-03	26	43	2	IPR008145
Domain	Guanylate_kin-like_dom	MAGI1 DLG5	1.62e-03	26	43	2	IPR008144
Domain	GuKc	MAGI1 DLG5	1.62e-03	26	43	2	SM00072
Domain	TRYPSIN_HIS	KLK14 C1RL LPA	1.71e-03	103	43	3	IPR018114
Domain	TRYPSIN_SER	KLK14 C1RL LPA	1.86e-03	106	43	3	PS00135
Domain	TRYPSIN_HIS	KLK14 C1RL LPA	1.91e-03	107	43	3	PS00134
Domain	Peptidase_S1A	KLK14 C1RL LPA	2.23e-03	113	43	3	IPR001314
Domain	TRYPSIN_DOM	KLK14 C1RL LPA	2.35e-03	115	43	3	PS50240
Domain	Tryp_SPc	KLK14 C1RL LPA	2.46e-03	117	43	3	SM00020
Domain	Trypsin	KLK14 C1RL LPA	2.71e-03	121	43	3	PF00089
Domain	Trypsin_dom	KLK14 C1RL LPA	2.71e-03	121	43	3	IPR001254
Domain	Peptidase_S1_PA	KLK14 C1RL LPA	2.84e-03	123	43	3	IPR009003
Domain	EF_Hand_1_Ca_BS	SPARCL1 PLCH1 RPTN	7.58e-03	175	43	3	IPR018247
Domain	Kinase-like_dom	STK38 DYRK1A SMG1 FGFR4 CLK1	7.83e-03	542	43	5	IPR011009
Domain	Protein_kinase_ATP_BS	STK38 DYRK1A FGFR4 CLK1	1.10e-02	379	43	4	IPR017441
Pubmed	Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.	CD8B CD8B2	1.64e-06	2	45	2	5558567
Pubmed	Cloning and modeling of CD8 beta in the amphibian ambystoma Mexicanum. Evolutionary conserved structures for interactions with major histocompatibility complex (MHC) class I molecules.	CD8B CD8B2	1.64e-06	2	45	2	12034498
Pubmed	Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner.	RAG1 IRF4	1.64e-06	2	45	2	33584655
Pubmed	Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders.	DYRK1A CLK1	1.64e-06	2	45	2	37607329
Pubmed	Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions.	CD8B CD8B2	1.64e-06	2	45	2	3035575
Pubmed	Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8).	CD8B CD8B2	1.64e-06	2	45	2	3498943
Pubmed	An immunological role for the CD8 beta-chain.	CD8B CD8B2	1.64e-06	2	45	2	1534146
Pubmed	Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses.	TAF15 THRAP3	1.64e-06	2	45	2	24055347
Pubmed	Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.	CD8B CD8B2	1.64e-06	2	45	2	8108731
Pubmed	Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism.	RAG1 IRF4	1.64e-06	2	45	2	27762344
Pubmed	Duality of the murine CD8 compartment.	CD8B CD8B2	1.64e-06	2	45	2	24594598
Pubmed	Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.	CD8B CD8B2	1.64e-06	2	45	2	7889415
Pubmed	Murine Ly-3 restriction fragment length polymorphism and transcript size differences.	CD8B CD8B2	1.64e-06	2	45	2	2576243
Pubmed	AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas.	CD8B CD8B2	1.64e-06	2	45	2	3025647
Pubmed	Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.	CD8B CD8B2	1.64e-06	2	45	2	2452747
Pubmed	Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes.	CD8B CD8B2	1.64e-06	2	45	2	9233619
Pubmed	Stalk region of beta-chain enhances the coreceptor function of CD8.	CD8B CD8B2	1.64e-06	2	45	2	12847256
Pubmed	The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.	CD8B CD8B2	1.64e-06	2	45	2	9647223
Pubmed	The IB-peptide marker and the Ly-3 surface alloantigen: structural studies of a V kappa-region polymorphism and a T-cell marker determined by linked genes.	CD8B CD8B2	1.64e-06	2	45	2	408079
Pubmed	Transcriptional diversity at the duplicated human CD8 beta loci.	CD8B CD8B2	1.64e-06	2	45	2	8436166
Pubmed	Characterization of the mouse CD8 beta chain-encoding gene promoter region.	CD8B CD8B2	1.64e-06	2	45	2	8781121
Pubmed	Structure and expression of the Lyt-3a gene of C.AKR mice.	CD8B CD8B2	1.64e-06	2	45	2	3169881
Pubmed	Esr, a second locus in the house mouse controlling esterase-5.	CD8B CD8B2	1.64e-06	2	45	2	7103930
Pubmed	Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.	CD8B CD8B2	4.91e-06	3	45	2	3258885
Pubmed	Ly-36: a new mouse lymphocyte alloantigen defined by a Mus musculus molossinus-specific monoclonal antibody and controlled by a gene linked to Ly-2/3 region on chromosome 6.	CD8B CD8B2	4.91e-06	3	45	2	3378837
Pubmed	CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.	CD8B CD8B2	4.91e-06	3	45	2	22081144
Pubmed	Recent duplication of the two human CD8 beta-chain genes.	CD8B CD8B2	4.91e-06	3	45	2	1541829
Pubmed	Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.	CD8B CD8B2	4.91e-06	3	45	2	100557
Pubmed	Zinc is essential for binding of p56(lck) to CD4 and CD8alpha.	CD8B CD8B2	4.91e-06	3	45	2	9830036
Pubmed	Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer.	CD8B CD8B2	4.91e-06	3	45	2	16356863
Pubmed	Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation.	RAG1 PRLR	4.91e-06	3	45	2	15650748
Pubmed	Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.	CD8B CD8B2	4.91e-06	3	45	2	4547628
Pubmed	Linkage of a 7S RNA sequence and kappa light chain genes in the mouse.	CD8B CD8B2	4.91e-06	3	45	2	2998983
Pubmed	Molecular biology and function of CD4 and CD8.	CD8B CD8B2	4.91e-06	3	45	2	2493728
Pubmed	Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene.	CD8B CD8B2	4.91e-06	3	45	2	9218488
Pubmed	A new mouse lymphocyte alloantigen (Ly-35) controlled by the Ly-2/3 region on chromosome 6.	CD8B CD8B2	4.91e-06	3	45	2	3346044
Pubmed	Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells.	RAG1 IRF4	4.91e-06	3	45	2	33859042
Pubmed	IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance.	RAG1 IRF4	4.91e-06	3	45	2	37469513
Pubmed	Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.	CD8B CD8B2	4.91e-06	3	45	2	23311920
Pubmed	Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.	CD8B CD8B2	4.91e-06	3	45	2	12810689
Pubmed	A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.	CD8B CD8B2	4.91e-06	3	45	2	9126989
Pubmed	CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation.	CD8B CD8B2	4.91e-06	3	45	2	11754824
Pubmed	The synthesis and processing of beta-glucuronidase in normal and egasyn deficient mouse kidney.	CD8B CD8B2	4.91e-06	3	45	2	7236294
Pubmed	Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells.	CD8B CD8B2	4.91e-06	3	45	2	31980555
Pubmed	An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.	CD8B CD8B2	4.91e-06	3	45	2	19109142
Pubmed	Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse.	CD8B CD8B2	4.91e-06	3	45	2	9878266
Pubmed	Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.	CD8B CD8B2	4.91e-06	3	45	2	19625641
Pubmed	The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.	CD8B CD8B2	4.91e-06	3	45	2	18929574
Pubmed	Recombination between kappa chain genetic markers in the mouse.	CD8B CD8B2	4.91e-06	3	45	2	6437974
Pubmed	Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells.	CD8B CD8B2	4.91e-06	3	45	2	11131152
Pubmed	Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.	CD8B CD8B2	4.91e-06	3	45	2	10795739
Pubmed	Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.	CD8B CD8B2	4.91e-06	3	45	2	8064243
Pubmed	Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice.	CD8B CD8B2	4.91e-06	3	45	2	24807710
Pubmed	CD8beta knockout mice mount normal anti-viral CD8+ T cell responses--but why?	CD8B CD8B2	4.91e-06	3	45	2	19088062
Pubmed	CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.	CD8B CD8B2	4.91e-06	3	45	2	17506031
Pubmed	Bop: a new T-cell-restricted gene located upstream of and opposite to mouse CD8b.	CD8B CD8B2	4.91e-06	3	45	2	7590968
Pubmed	Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.	CD8B CD8B2	4.91e-06	3	45	2	11719190
Pubmed	Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis.	CD8B CD8B2	4.91e-06	3	45	2	2875941
Pubmed	Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.	CD8B CD8B2	4.91e-06	3	45	2	14568922
Pubmed	The Bop gene adjacent to the mouse CD8b gene encodes distinct zinc-finger proteins expressed in CTLs and in muscle.	CD8B CD8B2	4.91e-06	3	45	2	9013956
Pubmed	The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers.	CD8B CD8B2	4.91e-06	3	45	2	9973530
Pubmed	Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.	RAG1 IRF4	4.91e-06	3	45	2	29221730
Pubmed	Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation.	CD8B CD8B2	4.91e-06	3	45	2	8423051
Pubmed	Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes. Absence of an intervening sequence between V- and J-like gene segments.	CD8B CD8B2	4.91e-06	3	45	2	2784466
Pubmed	Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8.	CD8B CD8B2	4.91e-06	3	45	2	7710778
Pubmed	Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding.	CD8B CD8B2	4.91e-06	3	45	2	16951356
Pubmed	Recombination between kappa chain genetic markers and the Lyt-3 locus.	CD8B CD8B2	4.91e-06	3	45	2	6411613
Pubmed	Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development.	CD8B CD8B2	4.91e-06	3	45	2	15661911
Pubmed	Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.	CD8B CD8B2	9.81e-06	4	45	2	12459555
Pubmed	TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.	RAG1 IRF4	9.81e-06	4	45	2	23011795
Pubmed	CD8α dendritic cells drive establishment of HSV-1 latency.	CD8B CD8B2	9.81e-06	4	45	2	24695322
Pubmed	The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation.	CD8B CD8B2	9.81e-06	4	45	2	18523287
Pubmed	CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.	CD8B CD8B2	9.81e-06	4	45	2	21115736
Pubmed	{gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells.	CD8B CD8B2	9.81e-06	4	45	2	16203967
Pubmed	cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.	CD8B CD8B2	9.81e-06	4	45	2	24297179
Pubmed	CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.	RAG1 IRF4	9.81e-06	4	45	2	32034085
Pubmed	CD8 is needed for development of cytotoxic T cells but not helper T cells.	CD8B CD8B2	9.81e-06	4	45	2	1673361
Pubmed	The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.	DYRK1A RAG1	9.81e-06	4	45	2	25998054
Pubmed	Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.	RAG1 IRF4	9.81e-06	4	45	2	27525438
Pubmed	Ly antigens associated with T cell recognition and effector function.	CD8B CD8B2	9.81e-06	4	45	2	6442265
Pubmed	T cell killing does not require the formation of a stable mature immunological synapse.	CD8B CD8B2	9.81e-06	4	45	2	15048111
Pubmed	CSF-1 in Inflammatory and Arthritic Pain Development.	RAG1 IRF4	9.81e-06	4	45	2	30120124
Pubmed	CD3 delta establishes a functional link between the T cell receptor and CD8.	CD8B CD8B2	9.81e-06	4	45	2	12215456
Pubmed	Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.	CD8B CD8B2	9.81e-06	4	45	2	8537123
Pubmed	Generation and function of bone marrow-derived dendritic cells from CD4/CD8(-/-) double-knockout mice.	CD8B CD8B2	9.81e-06	4	45	2	10369133
Pubmed	CD8-β ADP-ribosylation affects CD8(+) T-cell function.	CD8B CD8B2	1.63e-05	5	45	2	23575529
Pubmed	Impairment of T cell development in deltaEF1 mutant mice.	CD8B CD8B2	1.63e-05	5	45	2	9126927
Pubmed	Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.	CD8B CD8B2	1.63e-05	5	45	2	25427562
Pubmed	GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation.	RAG1 IRF4	1.63e-05	5	45	2	26365427
Pubmed	Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.	CD8B CD8B2	1.63e-05	5	45	2	17082573
Pubmed	A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.	CD8B CD8B2	1.63e-05	5	45	2	25548254
Pubmed	The organization of the immunoglobulin kappa locus in mice.	CD8B CD8B2	1.63e-05	5	45	2	3138071
Pubmed	CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.	CD8B CD8B2	1.63e-05	5	45	2	11403253
Pubmed	TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17.	RAG1 IRF4	1.63e-05	5	45	2	29563337
Pubmed	Chromosomal localization of the genes encoding rat CD4, CD8alpha, and CD8beta.	CD8B CD8B2	1.63e-05	5	45	2	8753864
Pubmed	IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses.	RAG1 IRF4	1.63e-05	5	45	2	23706669
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	STK38 DYRK1A KAT7 SMG1 FGFR4 SNX9 CLK1 THRAP3	1.95e-05	910	45	8	36736316
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	STK38 DYRK1A TAF15 CLK1 THRAP3	1.96e-05	255	45	5	15324660
Pubmed	Sequence and evolution of the human T-cell antigen receptor beta-chain genes.	CD8B CD8B2	2.45e-05	6	45	2	3860845
Pubmed	CD4+ T cell immunity is dependent on an intrinsic stem-like program.	RAG1 IRF4	2.45e-05	6	45	2	38168955
Cytoband	16p12.3	SMG1 TMC5	5.17e-04	34	45	2	16p12.3
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MAGI1 DLG5	6.33e-04	26	26	2	904
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CD8B PLCH1 TMC5 LRRC36	2.42e-05	167	45	4	25af48c640e67848594f5902867ba325fc105da4
ToppCell	Control\|World / group, cell type (main and fine annotations)	MAGI1 PLCH1 TMC5 LRRC36	2.48e-05	168	45	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY10 ADGRG1 FGFR4 ACACB	2.78e-05	173	45	4	66488d01e03264fb193285470901c9c4182fbae8
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ADGRG1 IRF4 SNX9 GEM	2.97e-05	176	45	4	56c055488e34605d32562571a2fee621b47c9441
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CHRDL1 SPARCL1 FGFR4 CCDC85A	2.97e-05	176	45	4	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK14 ADGRG1 SPARCL1 CCDC85A	3.18e-05	179	45	4	fca111789d7354de7ae4cd38253aa0685c0cb2d2
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK14 ADGRG1 SPARCL1 CCDC85A	3.18e-05	179	45	4	c3e53a3b8e59f7245d737386a1dd0f9d7aa5fb61
ToppCell	(1)_T_cells-(1)_T_regulatory\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	IRF4 SNX9 GEM PRLR	3.54e-05	184	45	4	3cbf81757653652441843d85cb7ec1dcf25ca1b0
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 SNX9 THRAP3 VPS13C	3.54e-05	184	45	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	GREB1L MAGI1 ATP1A2 ACACB	3.54e-05	184	45	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 SPARCL1 ATP1A2 GEM	3.61e-05	185	45	4	7b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 SPARCL1 ATP1A2 GEM	3.61e-05	185	45	4	e9033a03d574956cf3ae228740b3166e40a6397f
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHRDL1 DLG5 SPARCL1 GEM	3.61e-05	185	45	4	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 SPARCL1 ATP1A2 GEM	3.61e-05	185	45	4	578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHRDL1 SPARCL1 ATP1A2 GEM	3.69e-05	186	45	4	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHRDL1 SPARCL1 ATP1A2 GEM	3.85e-05	188	45	4	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	MAGI1 PLCH1 TMC5 LRRC36	3.85e-05	188	45	4	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	facs-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHRDL1 SPARCL1 FGFR4 ATP1A2	3.93e-05	189	45	4	bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHRDL1 SPARCL1 FGFR4 ATP1A2	3.93e-05	189	45	4	40cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCell	facs-Heart-RV-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	89d1d686cc683206534e2157554d7d0df5d53497
ToppCell	facs-SCAT-Fat-18m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	b0c9dae8189d407c94964c6bfe3ef92035245357
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	facs-Heart-RV-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	65ba6c4f4a2905c0bf4ff99518ae49e3dfd5e640
ToppCell	facs-SCAT-Fat-18m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	ee63dc04e91ad49aa7820c98e97261176ecebaa6
ToppCell	facs-SCAT-Fat-18m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	0e50808bfc3d0820524c8470ae3e8250819d65b2
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.01e-05	190	45	4	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	facs-SCAT-Fat-3m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.09e-05	191	45	4	a0018f88f7132477cc467ee15db029a585290595
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHRDL1 SPARCL1 FGFR4 ATP1A2	4.09e-05	191	45	4	cd497abed9e00e4e0becd9dbc036c6e7a60ae791
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHRDL1 SPARCL1 ATP1A2 GEM	4.09e-05	191	45	4	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHRDL1 SPARCL1 ATP1A2 GEM	4.09e-05	191	45	4	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	facs-SCAT-Fat-3m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.09e-05	191	45	4	6b9bbf4a63d4e9a8075bb06c2aa644fcf4ee88b8
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 PLCH1 TMC5 LRRC36	4.09e-05	191	45	4	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	facs-SCAT-Fat-3m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.09e-05	191	45	4	90f0c193dce267a4f1a9b2501f636dafd0a34cf7
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	IRF4 CD8B CLK1 GEM	4.09e-05	191	45	4	2ffd40ebf1d63e61a97208ddcbeb6a86e409f9d8
ToppCell	droplet-Fat-Gat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 SPARCL1 ACACB CCDC85A	4.18e-05	192	45	4	c312e39003c51503c9f648332fb5c6218f33f99b
ToppCell	droplet-Fat-Gat-18m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 SPARCL1 ACACB CCDC85A	4.18e-05	192	45	4	df09056f0e562f53b6fb30b674d2d83e9eb857d0
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	C1RL ACACB PRLR LPA	4.18e-05	192	45	4	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	droplet-Lung-30m-Mesenchymal\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHRDL1 SPARCL1 FGFR4 ATP1A2	4.18e-05	192	45	4	5d5bec238b196f0b3e727fd94f078d6ae524cb01
ToppCell	droplet-Fat-Gat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 SPARCL1 ACACB CCDC85A	4.18e-05	192	45	4	133b3ad251d72ff31e45e1dc6217945516ac63de
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHRDL1 SPARCL1 FGFR4 ATP1A2	4.18e-05	192	45	4	5876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHRDL1 SPARCL1 FGFR4 ATP1A2	4.26e-05	193	45	4	fa45042d30f9cfeed10e23270a78f18551219cfa
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 SMG1 CD8B VPS13C	4.26e-05	193	45	4	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHRDL1 SPARCL1 FGFR4 ATP1A2	4.26e-05	193	45	4	ab511ea9e09216a965b3ae5a94f8c3c1ae33d944
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 IRF4 GEM THRAP3	4.35e-05	194	45	4	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CHRDL1 SPARCL1 ATP1A2 GEM	4.44e-05	195	45	4	4dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	MAGI1 ADGRG1 SPARCL1 CCDC85A	4.44e-05	195	45	4	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	Control-Epithelial\|Control / Disease state, Lineage and Cell class	MAGI1 PLCH1 TMC5 LRRC36	4.44e-05	195	45	4	1798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCell	COPD-Stromal-Myofibroblast\|COPD / Disease state, Lineage and Cell class	CHRDL1 SPARCL1 FGFR4 GEM	4.53e-05	196	45	4	af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|GI_small-bowel / Manually curated celltypes from each tissue	ADGRG1 IRF4 SNX9 GEM	4.53e-05	196	45	4	5755ca4abcae3717894bbf7cbd49bca0a3a03067
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 SPARCL1 FGFR4 GEM	4.53e-05	196	45	4	9737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 SPARCL1 FGFR4 GEM	4.53e-05	196	45	4	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo\|GI_small-bowel / Manually curated celltypes from each tissue	ADGRG1 IRF4 SNX9 GEM	4.53e-05	196	45	4	181f3c1af565355b29f20ca6074147c313ca3477
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 SPARCL1 FGFR4 GEM	4.62e-05	197	45	4	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CHRDL1 SPARCL1 ATP1A2 GEM	4.71e-05	198	45	4	637f11e292b90d86cdc0d0d828eb26f38289c25b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MAGI1 PLCH1 TMC5 LRRC36	4.80e-05	199	45	4	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 SPARCL1 FGFR4 GEM	4.80e-05	199	45	4	28c1722deef3b8347371c7359be7c64b95780de3
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CHRDL1 SPARCL1 ATP1A2 GEM	4.80e-05	199	45	4	a207b4891881149d4c50721310690fd794157723
ToppCell	Fibroblasts\|World / lung cells shred on cell class, cell subclass, sample id	CHRDL1 SPARCL1 FGFR4 ATP1A2	4.80e-05	199	45	4	e2b6752fcabd5249a166486ae6796f2c97c1fcaf
ToppCell	distal-mesenchymal-Alveolar_Fibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 SPARCL1 FGFR4 GEM	4.80e-05	199	45	4	655d07cf9a2fd9b945a2ed4f824cba0297de72a8
ToppCell	proximal-3-mesenchymal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	94250991f78ea56810412d00a4bb645eb975478c
ToppCell	Biopsy_Other_PF-Mesenchymal-Myofibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Radial_glial\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	ADGRG1 SPARCL1 ATP1A2 GEM	4.89e-05	200	45	4	4477591efada4007bab1f689017e3ac285267d29
ToppCell	3'-Parenchyma_lung-Mesenchymal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	ba5ed66b05caa1be0bbf8d54c4e72a782b8d9833
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	proximal-mesenchymal-Adventitial_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	58c5870030192b337e7d883044948634fcd17d2c
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	a510deaada669e690329183e18df02870bd204b3
ToppCell	proximal-mesenchymal-Adventitial_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	05486d86868f6a93429226063cca270f00dd8714
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	6e3d1ae0ef84d3075afa40129a41169996462672
ToppCell	proximal-mesenchymal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	29f3a5c85404c6537d6405d599ebae281e0d4d4f
ToppCell	Parenchymal-10x3prime_v2-Stromal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	f6be0f24e607abb9007823a54fb0b24d04990a89
ToppCell	proximal-3-mesenchymal-Adventitial_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	869d45b71efd395d050873db5fee2ed0443d5e6f
ToppCell	Biopsy_Other_PF-Mesenchymal\|Biopsy_Other_PF / Sample group, Lineage and Cell type	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	d6fcdd48858b53b5a8d18ae14b2dc4d9af41b070
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHRDL1 SPARCL1 FGFR4 GEM	4.89e-05	200	45	4	dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	STK38 RNF38 CD8B	2.60e-04	123	45	3	511b7c20a4a85e49980936d52af7dbca19bb848e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 PLCH1 PRLR	4.13e-04	144	45	3	cc11cce43d1af8ac63140d05faf215ae9a10cde1
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD8B PLCH1 TMC5	4.47e-04	148	45	3	d44f6c5fc8d1fce4046598030a48fa57ed520a6a
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytotoxic_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DLG5 ZNF225 ZNF284	4.93e-04	153	45	3	df2130689e53748e820a5835fa396fe82a5d2c7c
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD8-Trm_gut_CD8\|bone_marrow / Manually curated celltypes from each tissue	KLK14 CD8B CD8B2	5.02e-04	154	45	3	93145a1bc5712ae664690b03a9e00ce1f92cfc7e
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-effector_CD8-positive,_alpha-beta_T_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IRF4 CD8B CCDC85A	5.21e-04	156	45	3	b0511ce81c446482339def3a0945fcbba6da35d0
ToppCell	droplet-Liver-LIVER_NPC-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 CD8B GEM	5.51e-04	159	45	3	997963d879e5819683793cddf5e1acff1b81a1b8
ToppCell	droplet-Liver-LIVER_NPC\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 CD8B GEM	5.51e-04	159	45	3	e4eaa88772835d6b78e1a18a0cec52de51e80339
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	SPARCL1 ATP1A2 GEM	5.61e-04	160	45	3	d783d29150033e9181c0e30870070268fed3fd85
ToppCell	COVID_non-vent-Lymphocytic-Dendritic-pDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CHRDL1 IRF4 LRRC36	5.61e-04	160	45	3	61f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell	COVID_non-vent-Lymphocytic-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CHRDL1 IRF4 LRRC36	5.61e-04	160	45	3	34b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-LMPP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CHRDL1 ZNF225 PLCH1	5.61e-04	160	45	3	60fa1c717410aad7e8647703cb416cd7617cac29
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 SPARCL1 PRLR	5.61e-04	160	45	3	1e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D175\|Adult / Lineage, Cell type, age group and donor	GREB1L CHRDL1 GEM	5.72e-04	161	45	3	048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADGRG1 CD8B CD8B2	5.72e-04	161	45	3	a480107b1c7773f2081afca2657e0b7fc88a5645
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 FGFR4 TMC5	5.82e-04	162	45	3	3a1cbfed5a063131d49e3c1584f62b12660ecb36
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI1 FGFR4 TMC5	5.82e-04	162	45	3	04b3c38bb27fa369a9ac5b60883f8b058abc5180
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 SPARCL1 CCDC85A	5.82e-04	162	45	3	465cb483f41023d6125ea147e16f404d8e8dc9bb
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GREB1L MAGI1 TMC5	5.82e-04	162	45	3	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FGFR4 CD8B VPS13C	5.92e-04	163	45	3	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPHLN1 TAF15 CD8B	5.92e-04	163	45	3	a24db9d266a40f3bffe4f18d277bc269791b4560
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	MAGI1 SPARCL1 CCDC85A	6.14e-04	165	45	3	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	10x5'-Liver-Myeloid_Dendritic-pDC\|Liver / Manually curated celltypes from each tissue	CHRDL1 IRF4 LRRC36	6.25e-04	166	45	3	24dfa9f3e0842f9ab8350bf6a52ae0d10f2a0c44
ToppCell	-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	CHRDL1 SPARCL1 FGFR4	6.58e-04	169	45	3	8ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCell	Healthy_donor-CD8+_T_naive\|Healthy_donor / disease group, cell group and cell class (v2)	FGFR4 CD8B CD8B2	6.58e-04	169	45	3	66216758e581365f10c2a66714d83a606ad23af0
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)\|356C / Donor, Lineage, Cell class and subclass (all cells)	MAGI1 SPARCL1 CCDC85A	6.58e-04	169	45	3	605cc2638271803cf1d972ab3fa8f13f89666376
Drug	Flunisolide [3385-03-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	GREB1L DYRK1A ADCY10 TAF15 PRLR	3.24e-05	195	43	5	3828_UP
Drug	Desipramine hydrochloride [58-28-6]; Up 200; 13.2uM; MCF7; HT_HG-U133A	GREB1L DYRK1A CNPPD1 TAF15 PLCH1	3.24e-05	195	43	5	3212_UP
Drug	Molsidomine [25717-80-0]; Up 200; 16.6uM; MCF7; HT_HG-U133A	DYRK1A ZNF343 ADGRG1 ACACB VPS13C	3.32e-05	196	43	5	2862_UP
Drug	Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; PC3; HT_HG-U133A	IRF4 TAF15 FGFR4 PLCH1 TMC5	3.40e-05	197	43	5	3752_DN
Drug	Sulfadimethoxine [122-11-2]; Up 200; 12.8uM; PC3; HT_HG-U133A	MAGI1 IRF4 FGFR4 VPS13C PRLR	3.56e-05	199	43	5	3702_UP
Drug	Hydralazine hydrochloride [304-20-1]; Up 200; 20.4uM; PC3; HT_HG-U133A	DYRK1A ZNF343 IRF4 FGFR4 ZNF225	3.56e-05	199	43	5	4282_UP
Disease	longevity, healthspan, parental longevity	IRF4 LPA	8.60e-04	29	44	2	EFO_0004300, EFO_0007796, EFO_0009762
Disease	progressive supranuclear palsy	IRF4 CD8B	9.83e-04	31	44	2	MONDO_0019037

Protein segments in the cluster

Peptide	Gene	Start	Entry
KSHRDPSNRHSYPQQ	FGFR4	131	P22455
HSHQYSDRRQPNISD	DYRK1A	36	Q13627
NRHFHYVNRQAQESP	ADCY10	1181	Q96PN6
PGHRQRDHESRYQNH	CLK1	86	P49759
NSFRADEHNRRYPVH	RAG1	116	P15918
SQRENYSHHTQDDRR	TAF15	151	Q92804
EPHQYSHRNRHSATP	GEM	36	P55040
SHLPSYELRHNQVES	ACACB	1231	O00763
DDNNRHATRHQAPTE	KAT7	241	O95251
KGSREYSRQPNEHHT	MAGI1	1296	Q96QZ7
NPEDYHRSIRHSSIQ	IRF4	436	Q15306
VRQVTHPNYNSRTHD	KLK14	111	Q9P0G3
HPNYNSRTHDNDLML	KLK14	116	Q9P0G3
DNHQEDEFRHYSPRQ	LRRC36	246	Q1X8D7
YHRLGTNNSTPQNHE	MINDY4B	36	A8MYZ0
QYNPHVHQLSSHSRS	DLG5	1426	Q8TDM6
EHFNPQRRYNPSSHV	SLC25A28	251	Q96A46
NAHHRAEYSQDSQRG	KIF24	726	Q5T7B8
ARQHHADYSNQLDPA	GREB1L	1291	Q9C091
YQLSIHEREDSPQSH	ATP1A2	486	P50993
LRHRNPDYLQHVSSS	CNPPD1	106	Q9BV87
RQRQAPSSDSHHEFL	CD8B2	56	A6NJW9
SHLSSIERYDPHQNQ	KLHL28	491	Q9NXS3
QPANREARHSYHRSH	CHRDL1	196	Q9BU40
RQRQAPSSDSHHEFL	CD8B	56	P10966
RVVVHPDYRQNESHN	C1RL	321	Q9NZP8
SQRNQTHRSSLHYKP	ADGRG1	36	Q9Y653
TPHQHNRTTENYPNA	LPA	56	P08519
QAQEDGSPHHRNVYS	CCDC85A	396	Q96PX6
PERSKSYSFHQSQHR	PPHLN1	156	Q8NEY8
QSTNPADNYHLARRR	TAF8	21	Q7Z7C8
PTNTNRSVNHRYKHF	SNX9	276	Q9Y5X1
HRTEFYRNLNHSLPS	STK38	241	Q15208
RLSRHNSISQDENYH	RNF38	131	Q9H0F5
NRQETPRFHARHYSV	SMG1	2181	Q96Q15
NLSRHQRTHSEEKPY	ZNF343	311	Q6P1L6
SRSYSPAHNRERNHP	THRAP3	51	Q9Y2W1
QPRNYSHHQLNRSSK	SPARCL1	166	Q14515
PSQHNPRSSYHNITD	PRLR	421	P16471
RLYNVRNPNASHSDS	VPS13C	2511	Q709C8
PRHSSSENNSHYVRK	PLCH1	896	Q4KWH8
TNSQRYSHQRAHSGE	ZNF225	411	Q9UK10
INAASSPQQRDRYSH	SRY	186	Q05066
SEFQSHPYHRASSRQ	TMC5	111	Q6UXY8
SQPERQDRDSHHNQS	RPTN	171	Q6XPR3
NSQGHSHQRAYREEE	ZNF284	411	Q2VY69