Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	synaptic receptor adaptor activity	SHANK2 SHANK3	3.38e-05	4	48	2	GO:0030160
GeneOntologyMolecularFunction	structural constituent of postsynaptic density	SHANK2 SHANK3	3.07e-04	11	48	2	GO:0098919
GeneOntologyMolecularFunction	structural constituent of postsynaptic specialization	SHANK2 SHANK3	4.34e-04	13	48	2	GO:0098879
Domain	PH_dom-like	SPTBN4 OBSCN SNTG2 OSBP2 ARHGEF10L	4.21e-03	426	47	5	IPR011993
Domain	PH	SPTBN4 OBSCN SNTG2 OSBP2	5.18e-03	278	47	4	SM00233
Domain	PH_DOMAIN	SPTBN4 OBSCN SNTG2 OSBP2	5.25e-03	279	47	4	PS50003
Domain	PH_domain	SPTBN4 OBSCN SNTG2 OSBP2	5.32e-03	280	47	4	IPR001849
Domain	PDZ	SHANK2 SNTG2 SHANK3	5.36e-03	141	47	3	PF00595
Domain	PDZ	SHANK2 SNTG2 SHANK3	6.13e-03	148	47	3	SM00228
Domain	-	SHANK2 SNTG2 SHANK3	6.36e-03	150	47	3	2.30.42.10
Domain	PDZ	SHANK2 SNTG2 SHANK3	6.48e-03	151	47	3	PS50106
Domain	PDZ	SHANK2 SNTG2 SHANK3	6.59e-03	152	47	3	IPR001478
Domain	Quinoprotein_ADH-like_supfam	WDR6 GEMIN5	7.87e-03	53	47	2	IPR011047
Domain	DH_1	OBSCN ARHGEF10L	1.10e-02	63	47	2	PS00741
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SPTBN4 FLYWCH1 ARID2 OBSCN NCKAP5L ARHGEF10L	8.36e-09	101	51	6	10997877
Pubmed	Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells.	CD19 STAT6	2.11e-06	2	51	2	31803941
Pubmed	Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development.	SHANK2 SHANK3	2.11e-06	2	51	2	10506216
Pubmed	The NuRD complex-mediated p21 suppression facilitates chemoresistance in BRCA-proficient breast cancer.	CDKN1A CHD4	2.11e-06	2	51	2	28842166
Pubmed	Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.	SHANK2 SHANK3	2.11e-06	2	51	2	33126897
Pubmed	Expression profiles of the autism-related SHANK proteins in the human brain.	SHANK2 SHANK3	2.11e-06	2	51	2	37953224
Pubmed	Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.	SHANK2 SHANK3	2.11e-06	2	51	2	36100669
Pubmed	Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.	SHANK2 SHANK3	2.11e-06	2	51	2	22699619
Pubmed	Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system.	SHANK2 SHANK3	2.11e-06	2	51	2	20800661
Pubmed	Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.	SHANK2 SHANK3	2.11e-06	2	51	2	31052177
Pubmed	Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.	SHANK2 SHANK3	2.11e-06	2	51	2	27199660
Pubmed	SHANK3 in vagal sensory neurons regulates body temperature, systemic inflammation, and sepsis.	SHANK2 SHANK3	2.11e-06	2	51	2	36845137
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	WDR6 ARID2 ABCD3 GPATCH2 GEMIN5 CHD4 RPL12	3.54e-06	440	51	7	34244565
Pubmed	Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models.	CDKN1A STAT6	6.32e-06	3	51	2	26993600
Pubmed	The Shank family of scaffold proteins.	SHANK2 SHANK3	6.32e-06	3	51	2	10806096
Pubmed	Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1.	CDKN1A STAT6	6.32e-06	3	51	2	11086062
Pubmed	Induction of natural IgE by glucocorticoids.	CD19 STAT6	6.32e-06	3	51	2	36098746
Pubmed	Translational neurobiology in Shank mutant mice--model systems for neuropsychiatric disorders.	SHANK2 SHANK3	6.32e-06	3	51	2	25917711
Pubmed	Modeling autism by SHANK gene mutations in mice.	SHANK2 SHANK3	6.32e-06	3	51	2	23583105
Pubmed	Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models.	SHANK2 SHANK3	6.32e-06	3	51	2	29970989
Pubmed	S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.	SHANK2 SHANK3	6.32e-06	3	51	2	34741005
Pubmed	Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients.	SHANK2 SHANK3	6.32e-06	3	51	2	32564287
Pubmed	SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.	SHANK2 SHANK3	1.26e-05	4	51	2	23897824
Pubmed	Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer.	CDKN1A EXO1	1.26e-05	4	51	2	18205772
Pubmed	Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.	SHANK2 SHANK3	1.26e-05	4	51	2	23468870
Pubmed	Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1).	CDKN1A STAT6	1.26e-05	4	51	2	23184467
Pubmed	Protrudin induces neurite formation by directional membrane trafficking.	RAB11FIP2 FKBP8	1.26e-05	4	51	2	17082457
Pubmed	The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.	SHANK2 SHANK3	1.26e-05	4	51	2	12626503
Pubmed	Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.	SHANK2 SHANK3	2.10e-05	5	51	2	16606358
Pubmed	The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.	SHANK2 SHANK3	2.10e-05	5	51	2	12504591
Pubmed	Distinct Requirements of CHD4 during B Cell Development and Antibody Response.	CD19 CHD4	2.10e-05	5	51	2	31042474
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	WDR6 ABCD3 GEMIN5 CHD4 RPL12	2.56e-05	237	51	5	29564676
Pubmed	Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity.	CDKN1A CD19	4.41e-05	7	51	2	22802351
Pubmed	Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells.	SHANK2 SHANK3	4.41e-05	7	51	2	15207857
Pubmed	CtIP-mediated resection is essential for viability and can operate independently of BRCA1.	CD19 EXO1	4.41e-05	7	51	2	24842372
Pubmed	Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.	SHANK2 SHANK3	4.41e-05	7	51	2	10527873
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	DNAJB1 TMEM201 ABCD3 GEMIN5 CHD4 FKBP8 RPL12	4.68e-05	657	51	7	36180527
Pubmed	The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.	SHANK2 SHANK3	5.87e-05	8	51	2	10958799
Pubmed	Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.	CD19 EXO1	5.87e-05	8	51	2	23254285
Pubmed	Sex Hormones Regulate SHANK Expression.	SHANK2 SHANK3	5.87e-05	8	51	2	30319350
Pubmed	Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle.	SNTG2 VCPIP1	5.87e-05	8	51	2	27404360
Pubmed	Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.	CDKN1A CD19	7.54e-05	9	51	2	23657012
Pubmed	PRMT5 is essential for B cell development and germinal center dynamics.	CDKN1A CD19	9.42e-05	10	51	2	30604754
Pubmed	IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.	CD19 STAT6	9.42e-05	10	51	2	21364747
Pubmed	Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth.	CDKN1A WNT6	9.42e-05	10	51	2	12591596
Pubmed	Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.	CD19 STAT6	1.15e-04	11	51	2	18599325
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	SHANK2 SHANK3	1.15e-04	11	51	2	26403076
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	SHANK2 SHANK3	1.63e-04	13	51	2	27050589
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN4 TRPC4	1.63e-04	13	51	2	18796539
Pubmed	Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation.	SHANK2 SHANK3	1.63e-04	13	51	2	14622142
Pubmed	Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.	SHANK2 SHANK3	1.90e-04	14	51	2	21795692
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PWWP2B WDR6 ARID2 GPATCH2 CHD4 FKBP8 ZNF579 NCKAP5L	2.05e-04	1116	51	8	31753913
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SHANK2 SHANK3	2.19e-04	15	51	2	34835087
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	SHANK2 SHANK3	2.83e-04	17	51	2	27779093
Pubmed	JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.	SHANK2 SHANK3	2.83e-04	17	51	2	26627310
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	DNAJB1 ABCD3 GEMIN5 CHD4 FKBP8 RPL12	3.32e-04	638	51	6	33239621
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	FLYWCH1 FER1L4 ARID2 TRPC4 OBSCN EXO1 ZNF579 NCKAP5L	3.63e-04	1215	51	8	15146197
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	WDR6 ABCD3 GEMIN5 CHD4 VCPIP1	3.65e-04	418	51	5	34709266
Pubmed	The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice.	CDKN1A STAT6	3.94e-04	20	51	2	21248711
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	DNAJB1 ARID2 ABCD3 GEMIN5 CHD4 RPL12 VCPIP1	4.07e-04	934	51	7	33916271
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNAJB1 CD19 WDR6 ABCD3 GEMIN5 RPL12	4.31e-04	670	51	6	22990118
Pubmed	Sin3a is essential for the genome integrity and viability of pluripotent cells.	CDKN1A CHD4	5.23e-04	23	51	2	22206758
Pubmed	Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.	OSBP2 SHANK3	5.70e-04	24	51	2	11258795
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	ARID2 CHD4	8.35e-04	29	51	2	36800290
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	SHANK2 SHANK3	8.35e-04	29	51	2	19208628
Pubmed	Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.	GSTK1 ABCD3 FKBP8 RPL12	8.92e-04	292	51	4	35545034
Pubmed	Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression.	CDKN1A GEMIN5	8.93e-04	30	51	2	34974536
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PWWP2B EXO1 GEMIN5 CHD4 ZNF579 VCPIP1	9.15e-04	774	51	6	15302935
Pubmed	Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.	OBSCN ABCD3 RPL12	9.53e-04	131	51	3	28031328
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SPTBN4 DENND2A SHANK2 ABCD3 GEMIN5 SHANK3 RPL12 PNMA8B	1.06e-03	1431	51	8	37142655
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	SNTG2 SHANK3	1.15e-03	34	51	2	30726710
Pubmed	The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.	ARID2 RPL12	1.22e-03	35	51	2	32504627
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	DNAJB1 WDR6 ABCD3 CHD4 FKBP8	1.22e-03	547	51	5	37267103
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	DNAJB1 WDR6 ARID2 GEMIN5 VCPIP1	1.24e-03	549	51	5	38280479
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	DNAJB1 WDR6 OBSCN	1.35e-03	148	51	3	35676246
Pubmed	Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.	ARID2 CHD4	1.36e-03	37	51	2	24335282
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DNAJB1 SHANK2 FLYWCH1 ARID2 ABCD3 GEMIN5 FKBP8 ZNF579	1.41e-03	1497	51	8	31527615
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	GSTK1 OBSCN SHANK3 RPL12	1.42e-03	331	51	4	29199018
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD4 ZNF579	1.43e-03	38	51	2	33283408
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	DNAJB1 TMEM201 ABCD3 FKBP8 VCPIP1	1.44e-03	568	51	5	37774976
Interaction	MEST interactions	ABCD3 ZNF205 ZNF579 C6orf47	4.27e-06	45	49	4	int:MEST
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A KIF26B SNTG2 OSBP2 SHANK3	2.20e-06	188	50	5	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	TCGA-Brain-Recurrent_Tumor-Low_Grade_Glioma-Oligodendroglioma\|TCGA-Brain / Sample_Type by Project: Shred V9	ALKAL1 CD19 WNT6 GBX1	1.47e-05	132	50	4	6a6718582edfc59c63f2c8f753be81e0f4a7246b
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND2A TRPC4 GDF10 SHANK3	4.14e-05	172	50	4	073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	DENND2A SNTG2 OSBP2 SHANK3	4.24e-05	173	50	4	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CDKN1A PWWP2B CD19 PCDHGC3	4.63e-05	177	50	4	37d1abe1a9d8f2b8f4d146bbf1db94104eab6593
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DNAJB1 KIF26B SNTG2 TMEM215	5.05e-05	181	50	4	7e3bcfa2ba5b98a7df5854aa6e7a31e9a71faa8a
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DENND2A WNT6 SNTG2 SHANK3	5.16e-05	182	50	4	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND2A TRPC4 GBX1 GDF10	5.38e-05	184	50	4	1c857126c0ea0671f0d60b048efca288d348d653
ToppCell	droplet-Spleen-nan-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF26B FER1L4 EXO1 SHANK3	5.73e-05	187	50	4	c81d11d9fdc22dc39222f62c2888025c2e8c3e65
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	KIF26B SNTG2 OSBP2 SHANK3	5.73e-05	187	50	4	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A SNTG2 OSBP2 SHANK3	5.85e-05	188	50	4	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel\|Adult / Lineage, Cell type, age group and donor	DENND2A SNTG2 OSBP2 SHANK3	6.10e-05	190	50	4	91bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A SNTG2 OSBP2 SHANK3	6.10e-05	190	50	4	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CDKN1A DNAJB1 SNTG2 SHANK3	6.10e-05	190	50	4	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A KIF26B TRPC4 OBSCN	6.61e-05	194	50	4	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	Control-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	DENND2A SNTG2 OSBP2 RPL12	6.88e-05	196	50	4	e0cf617b0f5d9c3c19574f587a3d0ccbf93d8ca4
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A SNTG2 OSBP2 SHANK3	6.88e-05	196	50	4	09a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A SNTG2 OSBP2 SHANK3	6.88e-05	196	50	4	e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCell	normal_Lung-T/NK_cells-CD4+_Th\|T/NK_cells / Location, Cell class and cell subclass	CDKN1A DNAJB1 GSTK1 RPL12	7.01e-05	197	50	4	80b3902ceea242148a1f1707c633f66afedf5183
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A SNTG2 OSBP2 SHANK3	7.15e-05	198	50	4	b3a020522e064bb61949d38e442f24026e339364
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A SNTG2 OSBP2 SHANK3	7.15e-05	198	50	4	fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCell	droplet-Skin-nan-21m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN1A DNAJB1 WNT6 RPL12	7.15e-05	198	50	4	db9507386cdccbde7389a77667dbd0e5550ed4df
Disease	autosomal dominant polycystic kidney disease (is_marker_for)	CDKN1A STAT6	2.33e-04	14	48	2	DOID:898 (is_marker_for)
Disease	Non-steroidal anti-inflammatory and antirheumatic product use measurement	LMAN1L STAT6	2.68e-04	15	48	2	EFO_0009935
Disease	Autism Spectrum Disorders	SNTG2 FEV SHANK3	3.63e-04	85	48	3	C1510586
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	CDKN1A EXO1	3.90e-04	18	48	2	EFO_1000649, HP_0000131
Disease	descending aortic diameter	CDKN1A SPTBN4 STAT6	4.02e-04	88	48	3	EFO_0021788
Disease	JT interval	CDKN1A ARID2 OBSCN ZNF579	7.09e-04	248	48	4	EFO_0007885
Disease	colon adenocarcinoma (is_implicated_in)	CHD4 STAT6	8.21e-04	26	48	2	DOID:234 (is_implicated_in)
Disease	Autistic Disorder	SHANK2 SNTG2 CHD4 SHANK3	8.57e-04	261	48	4	C0004352
Disease	Child Development Disorders, Specific	CHD4 SHANK3	1.02e-03	29	48	2	C0085997
Disease	Child Development Deviations	CHD4 SHANK3	1.02e-03	29	48	2	C0085996
Disease	Developmental Disabilities	CHD4 SHANK3	1.09e-03	30	48	2	C0008073
Disease	right ventricular ejection fraction measurement	OBSCN SLC23A2	1.09e-03	30	48	2	EFO_0021816
Disease	Uterine leiomyoma, breast carcinoma	CDKN1A EXO1	1.25e-03	32	48	2	EFO_0000305, HP_0000131
Disease	Sclerocystic Ovaries	SPTBN4 PWWP2B ZNF205	1.68e-03	144	48	3	C1136382
Disease	Polycystic Ovary Syndrome	SPTBN4 PWWP2B ZNF205	1.68e-03	144	48	3	C0032460
Disease	autism spectrum disorder (implicated_via_orthology)	SHANK2 TRPC4 SHANK3	1.96e-03	152	48	3	DOID:0060041 (implicated_via_orthology)
Disease	Prostatic Neoplasms	CDKN1A GSTK1 ARID2 LDAH RPL12	3.19e-03	616	48	5	C0033578
Disease	Malignant neoplasm of prostate	CDKN1A GSTK1 ARID2 LDAH RPL12	3.19e-03	616	48	5	C0376358
Disease	basal cell carcinoma	BPIFB3 RAB11FIP2 EXO1	3.62e-03	189	48	3	EFO_0004193
Disease	oral squamous cell carcinoma (is_marker_for)	CDKN1A ARID2	4.75e-03	63	48	2	DOID:0050866 (is_marker_for)
Disease	Abdominal Aortic Aneurysm	CDKN1A LDAH	5.51e-03	68	48	2	EFO_0004214
Disease	allergic disease, age at onset	NFILZ STAT6	5.99e-03	71	48	2	EFO_0004847, MONDO_0005271
Disease	perceived unattractiveness to mosquitos measurement	NFILZ STAT6	6.16e-03	72	48	2	EFO_0008380

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTLPKVLLKLLPGFG	BPIFB3	96	P59826
LIPPLIKPGLLKAWG	AGPAT4-IT1	126	Q9H0P7
LLLPGKPDKSGRPIS	ARHGEF10L	716	Q9HCE6
LGLPKLYLPTGPRRG	CDKN1A	71	P38936
EPKPLLFLPAAGAGR	ALKAL1	41	Q6UXT8
GLAPLPFPGLSKLNL	FEV	166	Q99581
KQLLLPKRGPSTPGG	ARID2	1061	Q68CP9
GLPLPKTPEKRGDLI	DNAJB1	301	P25685
LKLRFGLLPLTGGPR	NFILZ	91	A0A5F9ZHS7
GPLLPSPARGLKFLK	NCKAP5L	446	Q9HCH0
PPKKRSILGLGQARP	FLYWCH1	256	Q4VC44
KLSFKGPRLALPGAG	LMAN1L	36	Q9HAT1
RQALRLLLPGPFPGK	KIF26B	141	Q2KJY2
RQLLKPPLKKLPLGG	FER1L4	1076	A9Z1Z3
PKLSFLKPGILTGRG	DDX58	651	O95786
KPRAKNASGRPLPLG	GDF10	151	P55107
PLLKKPGAASPLASR	PCDHGC3	771	Q9UN70
ALKPLPLLRPGQAKT	OSBP2	146	Q969R2
PPRKKPGLASFRLSG	OBSCN	7441	Q5VST9
LLRKKTLVPGPPGSS	FKBP8	101	Q14318
PGALLGPKPKLKGSL	GBX1	226	Q14549
PGAPLEKPGRREKLL	C6orf47	141	O95873
GIGFRKEKRNLPPLP	DENND2A	286	Q9ULE3
SPLKPFLKLSLGLPG	CD19	56	P15391
SGNKPPGLLPRKGLY	GSTK1	51	Q9Y2Q3
LRTLKAPDGLPALGP	MANEAL	26	Q5VSG8
QRPKGLGLGFPLPKS	GPATCH2	501	Q9NW75
GLRNDKDKPLPPLLA	CHD4	1391	Q14839
KDKPLPPLLARVGGN	CHD4	1396	Q14839
KKSGLFGLPPLAPLP	PWWP2B	41	Q6NUJ5
PDLPPQAKKAGRGLF	PNMA8B	421	Q9ULN7
REAPAFLKLPLGSPG	SNTG2	156	Q9NY99
KPLGPARASGLSKKP	EXO1	756	Q9UQ84
PGPKRKLYSAVPGRL	SHANK2	516	Q9UPX8
PLFGGRLTKPERGKL	ABCD3	491	P28288
LAKKAGLRGKPPPQS	TMEM215	111	Q68D42
SALAPKIGPLGLSPK	RPL12	26	P30050
LLGLPGALLKYIGPL	SLC23A2	231	Q9UGH3
PKLKSPLGKGPVTFR	SHANK3	1416	Q9BYB0
PLGKGPVTFRDPLLK	SHANK3	1421	Q9BYB0
LLGLRFLGAPAKPPL	STAT6	296	P42226
RLLRSLVFPGGKKPG	ZIK1	181	Q3SY52
FSGKPPEKLLPNRKG	FAM90A2P	121	Q658T7
KLPFLKRRGGGIDPT	GEMIN5	266	Q8TEQ6
GKALLPAVRTLKPPG	WNT6	266	Q9Y6F9
SKQPPTPLLGRKFFG	SPTBN4	2121	Q9H254
PKKPFLLGPQRLSSA	RAB11FIP2	211	Q7L804
KGQKLLLFPSPPGEA	TMEM201	536	Q5SNT2
IPLVGIKGAALPKLP	VCPIP1	356	Q96JH7
LLFPSRPGLLKDPGV	WDR6	516	Q9NNW5
KEKALFLPGGALPSP	ZNF205	81	O95201
GPLSLLAPLPAAGKK	ZNF579	321	Q8NAF0
PKSPLGLFIRKPFIK	TRPC4	351	Q9UBN4
KRPKLLIFIIPGNPG	LDAH	41	Q9H6V9