Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metalloendopeptidase activity	MMP20 BMP1 TLL2 MIPEP KEL MMP11	2.63e-05	120	97	6	GO:0004222
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.39e-04	4	97	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.39e-04	4	97	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.39e-04	4	97	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.39e-04	4	97	2	GO:0106309
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	3.46e-04	6	97	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	3.46e-04	6	97	2	GO:0062186
GeneOntologyMolecularFunction	metallopeptidase activity	MMP20 BMP1 TLL2 MIPEP KEL MMP11	4.34e-04	200	97	6	GO:0008237
Domain	ZINC_PROTEASE	MMP20 BMP1 TLL2 MIPEP KEL MMP11	8.86e-06	98	92	6	PS00142
Domain	ZnMc	MMP20 BMP1 TLL2 MMP11	1.19e-05	29	92	4	SM00235
Domain	Peptidase_Metallo	MMP20 BMP1 TLL2 MMP11	1.19e-05	29	92	4	IPR006026
Domain	MetalloPept_cat_dom	MMP20 BMP1 TLL2 MIPEP MMP11	4.96e-05	81	92	5	IPR024079
Domain	-	MMP20 BMP1 TLL2 MIPEP MMP11	4.96e-05	81	92	5	3.40.390.10
Domain	7-in-absentia-prot_TRAF-dom	SIAH1 SIAH2	7.18e-05	3	92	2	IPR018121
Domain	BMP_1/tolloid-like	BMP1 TLL2	7.18e-05	3	92	2	IPR015446
Domain	Sina	SIAH1 SIAH2	7.18e-05	3	92	2	PF03145
Domain	SINA-like	SIAH1 SIAH2	1.43e-04	4	92	2	IPR004162
Domain	DUF1908	MAST2 MAST4	1.43e-04	4	92	2	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST2 MAST4	1.43e-04	4	92	2	IPR015022
Domain	Znf_SIAH	SIAH1 SIAH2	1.43e-04	4	92	2	IPR013010
Domain	MAST_pre-PK_dom	MAST2 MAST4	1.43e-04	4	92	2	IPR023142
Domain	-	MAST2 MAST4	1.43e-04	4	92	2	1.20.1480.20
Domain	ZF_SIAH	SIAH1 SIAH2	2.38e-04	5	92	2	PS51081
Domain	Peptidase_M12A	BMP1 TLL2	3.55e-04	6	92	2	IPR001506
Domain	Astacin	BMP1 TLL2	3.55e-04	6	92	2	PF01400
Domain	ApoL	APOL3 APOL4	4.96e-04	7	92	2	IPR008405
Domain	ApoL	APOL3 APOL4	4.96e-04	7	92	2	PF05461
Domain	EGF_CA	BMP1 UMODL1 TLL2 LTBP2	8.60e-04	86	92	4	PF07645
Domain	EGF_Ca-bd_CS	BMP1 UMODL1 TLL2 LTBP2	1.35e-03	97	92	4	IPR018097
Domain	EGF_CA	BMP1 UMODL1 TLL2 LTBP2	1.45e-03	99	92	4	PS01187
Domain	EGF-like_CS	TMEM8B BMP1 UMODL1 TLL2 LTBP2 EPHA10	1.84e-03	261	92	6	IPR013032
Domain	EGF-type_Asp/Asn_hydroxyl_site	BMP1 UMODL1 TLL2 LTBP2	1.87e-03	106	92	4	IPR000152
Domain	EGF_2	TMEM8B BMP1 UMODL1 TLL2 LTBP2 EPHA10	1.99e-03	265	92	6	PS01186
Domain	-	SIAH1 SIAH2	2.10e-03	14	92	2	3.90.890.10
Domain	-	SIAH1 SIAH2	2.10e-03	14	92	2	2.60.210.10
Domain	Pept_M10A_Zn_BS	MMP20 MMP11	2.42e-03	15	92	2	IPR021158
Domain	SIAH-type	SIAH1 SIAH2	2.75e-03	16	92	2	IPR013323
Domain	RmlC_Cupin	CENPC GGCX	2.75e-03	16	92	2	IPR011051
Domain	EGF_CA	BMP1 UMODL1 TLL2 LTBP2	3.11e-03	122	92	4	SM00179
Domain	EGF-like_Ca-bd_dom	BMP1 UMODL1 TLL2 LTBP2	3.30e-03	124	92	4	IPR001881
Domain	Pept_M10A_stromelysin-type	MMP20 MMP11	3.49e-03	18	92	2	IPR016293
Domain	PDZ	ARHGAP23 MAST2 MAST4 TJP3	5.21e-03	141	92	4	PF00595
Domain	Hemopexin-like_dom	MMP20 MMP11	5.68e-03	23	92	2	IPR000585
Domain	Hemopexin-like_repeat	MMP20 MMP11	5.68e-03	23	92	2	IPR018487
Domain	M10A_MMP	MMP20 MMP11	5.68e-03	23	92	2	IPR033739
Domain	Hemopexin	MMP20 MMP11	5.68e-03	23	92	2	PF00045
Domain	HEMOPEXIN	MMP20 MMP11	5.68e-03	23	92	2	PS00024
Domain	-	MMP20 MMP11	5.68e-03	23	92	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP20 MMP11	5.68e-03	23	92	2	PS51642
Domain	HX	MMP20 MMP11	5.68e-03	23	92	2	SM00120
Domain	Pept_M10A	MMP20 MMP11	5.68e-03	23	92	2	IPR021190
Domain	EGF_3	TMEM8B BMP1 UMODL1 TLL2 LTBP2	6.12e-03	235	92	5	PS50026
Domain	EGF	TMEM8B BMP1 UMODL1 TLL2 LTBP2	6.12e-03	235	92	5	SM00181
Domain	PDZ	ARHGAP23 MAST2 MAST4 TJP3	6.17e-03	148	92	4	SM00228
Domain	Peptidase_M10	MMP20 MMP11	6.17e-03	24	92	2	PF00413
Domain	TRAF-like	SIAH1 SIAH2	6.17e-03	24	92	2	IPR008974
Domain	-	ARHGAP23 MAST2 MAST4 TJP3	6.47e-03	150	92	4	2.30.42.10
Domain	PDZ	ARHGAP23 MAST2 MAST4 TJP3	6.62e-03	151	92	4	PS50106
Pathway	REACTOME_COLLAGEN_FORMATION	COL17A1 COLGALT1 MMP20 BMP1 TLL2	3.42e-05	76	69	5	MM14573
Pathway	REACTOME_COLLAGEN_FORMATION	COL17A1 COLGALT1 MMP20 BMP1 TLL2	7.72e-05	90	69	5	M631
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	COL17A1 MMP20 BMP1 TLL2	2.22e-04	61	69	4	M27103
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL17A1 COLGALT1 BMP1 TLL2	2.22e-04	61	69	4	MM14637
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL17A1 COLGALT1 MMP20 BMP1 TLL2 LTBP2 MMP11	2.60e-04	258	69	7	MM14572
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL17A1 COLGALT1 BMP1 TLL2	3.19e-04	67	69	4	M26999
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.38e-18	12	104	8	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	6.17e-18	13	104	8	17668377
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.39e-17	8	104	7	17588759
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.07e-16	10	104	7	17984056
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.94e-15	13	104	7	7739628
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.30e-14	17	104	7	11245978
Pubmed	The homeobox transcription factor DUXBL controls exit from totipotency.	DUX4L9 DUX4L2 DUX4L4	1.04e-07	4	104	3	38509386
Pubmed	Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.	DUX4L9 DUX4L2 DUX4L4	1.04e-07	4	104	3	17911620
Pubmed	Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.	SIAH1 SIAH2 DCC	1.04e-07	4	104	3	9858595
Pubmed	Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.	SIAH1 SIAH2 DCC	1.04e-07	4	104	3	9334332
Pubmed	Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.	DUX4L9 DUX4L2 DUX4L4	2.59e-07	5	104	3	20063414
Pubmed	The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.	DUX4L9 DUX4L2 DUX4L4	9.01e-07	7	104	3	30765463
Pubmed	Fine tuning of the UPR by the ubiquitin ligases Siah1/2.	SIAH1 SIAH2	8.86e-06	2	104	2	24809345
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	8.86e-06	2	104	2	11032406
Pubmed	Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).	SIAH1 SIAH2	8.86e-06	2	104	2	8404535
Pubmed	Characterization of human homologs of the Drosophila seven in absentia (sina) gene.	SIAH1 SIAH2	8.86e-06	2	104	2	9403064
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	8.86e-06	2	104	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	8.86e-06	2	104	2	11207030
Pubmed	Dimerization of hSiah proteins regulates their stability.	SIAH1 SIAH2	8.86e-06	2	104	2	16899216
Pubmed	Inhibition of Siah ubiquitin ligase function.	SIAH1 SIAH2	8.86e-06	2	104	2	18850011
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	8.86e-06	2	104	2	3123997
Pubmed	Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.	DUX4L9 DUX4	8.86e-06	2	104	2	24145033
Pubmed	HFE mutations and hemochromatosis in Danish patients admitted for HFE genotyping.	HFE HRES1	8.86e-06	2	104	2	12512743
Pubmed	Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands.	HFE CYP2D6	8.86e-06	2	104	2	18300942
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	8.86e-06	2	104	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	8.86e-06	2	104	2	26297049
Pubmed	Generation and analysis of Siah2 mutant mice.	SIAH1 SIAH2	8.86e-06	2	104	2	14645526
Pubmed	Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6.	MPO CYP2D6	8.86e-06	2	104	2	11147929
Pubmed	SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.	SIAH1 SIAH2	8.86e-06	2	104	2	26654769
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	8.86e-06	2	104	2	15051713
Pubmed	Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families.	OTOF MYO15A	8.86e-06	2	104	2	37189200
Pubmed	Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.	DUX4L9 DUX4L2 DUX4L4	1.15e-05	15	104	3	35727972
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	DUX4L9 DUX4L2 DUX4L4	1.15e-05	15	104	3	30071041
Pubmed	Normal p53 function in primary cells deficient for Siah genes.	SIAH1 SIAH2	2.65e-05	3	104	2	12417719
Pubmed	The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.	SIAH1 SIAH2	2.65e-05	3	104	2	27776223
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	2.65e-05	3	104	2	2574001
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL2	2.65e-05	3	104	2	18824173
Pubmed	Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing.	OTOF MYO15A	2.65e-05	3	104	2	31250571
Pubmed	Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.	SIAH1 SIAH2	2.65e-05	3	104	2	12810624
Pubmed	Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.	SIAH1 SIAH2	2.65e-05	3	104	2	10681424
Pubmed	Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO.	SIAH1 SIAH2	2.65e-05	3	104	2	25561546
Pubmed	Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.	SIAH1 SIAH2	2.65e-05	3	104	2	21109632
Pubmed	The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.	SIAH1 SIAH2	2.65e-05	3	104	2	14645235
Pubmed	The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.	SIAH1 SIAH2	2.65e-05	3	104	2	11884614
Pubmed	Molecular basis of primary iron overload in India and the role of serum-derived factors in hepcidin regulation.	HFE GDF15	2.65e-05	3	104	2	23154866
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	2.65e-05	3	104	2	18286185
Pubmed	Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis.	MPO HFE	2.65e-05	3	104	2	15885363
Pubmed	Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.	SIAH1 SIAH2	2.65e-05	3	104	2	37078793
Pubmed	Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors.	HFE GDF15	2.65e-05	3	104	2	18657084
Pubmed	Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity.	SIAH1 SIAH2	2.65e-05	3	104	2	25202994
Pubmed	Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis?	MPO HFE	2.65e-05	3	104	2	20673159
Pubmed	An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.	SIAH1 SIAH2	2.65e-05	3	104	2	19043406
Pubmed	Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon.	SIAH1 SIAH2	2.65e-05	3	104	2	17998205
Pubmed	The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer.	SIAH1 SIAH2	2.65e-05	3	104	2	25528765
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	2.65e-05	3	104	2	1978251
Pubmed	Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.	CACTIN SRRM2	2.65e-05	3	104	2	28062851
Pubmed	The LMO2 oncogene regulates DNA replication in hematopoietic cells.	MPO KMT2B TAF6L CACTIN	2.83e-05	58	104	4	26764384
Pubmed	Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.	COL17A1 SIAH1 SIAH2	4.40e-05	23	104	3	9143490
Pubmed	Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.	HFE BMP1 SURF1 APOL3	5.00e-05	67	104	4	16806233
Pubmed	Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?	SIAH1 SIAH2	5.29e-05	4	104	2	15221006
Pubmed	Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia.	SIAH1 SIAH2	5.29e-05	4	104	2	22099302
Pubmed	Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.	SIAH1 SIAH2	5.29e-05	4	104	2	18070888
Pubmed	SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease.	SIAH1 SIAH2	5.29e-05	4	104	2	36307912
Pubmed	Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children.	MPO CYP2D6	5.29e-05	4	104	2	19593802
Pubmed	Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia.	SIAH1 SIAH2	5.29e-05	4	104	2	22128162
Pubmed	Mouse Apolipoprotein L9 is a phosphatidylethanolamine-binding protein.	APOL3 APOL4	5.29e-05	4	104	2	27697524
Pubmed	Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.	APOL3 APOL4	5.29e-05	4	104	2	11290834
Pubmed	DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.	DUX4L9 DUX4	5.29e-05	4	104	2	19829708
Pubmed	Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.	SIAH1 SIAH2	5.29e-05	4	104	2	15064394
Pubmed	The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.	APOL3 APOL4	5.29e-05	4	104	2	11944986
Pubmed	TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study.	GDF15 TNFRSF1A	5.29e-05	4	104	2	36508390
Pubmed	Siah-1 is associated with expression of hypoxia-inducible factor-1α in oral squamous cell carcinoma.	SIAH1 SIAH2	5.29e-05	4	104	2	27616748
Pubmed	P-TEFb is degraded by Siah1/2 in quiescent cells.	SIAH1 SIAH2	5.29e-05	4	104	2	35524561
Pubmed	Regulation of BOB.1/OBF.1 stability by SIAH.	SIAH1 SIAH2	5.29e-05	4	104	2	11483518
Pubmed	Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.	SIAH1 SIAH2	8.80e-05	5	104	2	19224863
Pubmed	SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.	SIAH1 SIAH2	8.80e-05	5	104	2	14654780
Pubmed	RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.	DUX4L2 DUX4	8.80e-05	5	104	2	19359275
Pubmed	hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.	SIAH1 SIAH2	8.80e-05	5	104	2	10207103
Pubmed	The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.	SIAH1 SIAH2	8.80e-05	5	104	2	28546513
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	BMP1 TLL2	8.80e-05	5	104	2	10479448
Pubmed	Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.	SIAH1 SIAH2	8.80e-05	5	104	2	11786535
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	SIAH1 FBXO11 SIAH2 FBXO22	1.27e-04	85	104	4	19028597
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SP100 ARHGAP23 PHRF1 MAST2 ZC3H3 ADCY6 GGCX TAF6L CACTIN RASAL3 HRES1 SRRM2	1.29e-04	1116	104	12	31753913
Pubmed	Differential gene expression during terminal erythroid differentiation.	APOL3 APOL4	1.32e-04	6	104	2	17764892
Pubmed	HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.	FBXO11 PTOV1	1.32e-04	6	104	2	21090589
Pubmed	SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation.	SIAH1 SIAH2	1.32e-04	6	104	2	23208506
Pubmed	The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.	APOL3 APOL4	1.32e-04	6	104	2	11374903
Pubmed	Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.	SIAH1 SIAH2	1.32e-04	6	104	2	16174773
Pubmed	Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.	CYP2D7 CYP2D6	1.32e-04	6	104	2	12171760
Pubmed	Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.	SIAH1 SIAH2	1.32e-04	6	104	2	15210114
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	MPO HFE CYP2D6 GDF15 SSTR3 MEST TNFRSF1A	1.37e-04	374	104	7	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	MPO HFE CYP2D6 GDF15 SSTR3 MEST TNFRSF1A	1.53e-04	381	104	7	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	MPO HFE CYP2D6 GDF15 SSTR3 MEST TNFRSF1A	1.56e-04	382	104	7	19170196
Pubmed	RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.	BMP1 LEFTY1 LTBP2	1.59e-04	35	104	3	32281291
Pubmed	A genome-wide association study of carotid atherosclerosis in HIV-infected men.	RYR3 MAST4	1.84e-04	7	104	2	20009918
Pubmed	Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia.	MPO CYP2D6	1.84e-04	7	104	2	19162321
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP2D7 CYP2D6	1.84e-04	7	104	2	30944282
Pubmed	Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.	UMODL1 PRDM15	1.84e-04	7	104	2	11528125
Pubmed	Mammalian small nucleolar RNAs are mobile genetic elements.	CENPC MAGED2	1.84e-04	7	104	2	17154719
Pubmed	Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis.	TRPV4 TNFRSF1A	2.45e-04	8	104	2	34624205
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.32e-11	27	104	6	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.93e-10	117	104	8	chr4q35
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	TTC24 GON4L VHLL	5.77e-04	71	104	3	chr1q22
Cytoband	22q13.1	CYP2D6 SSTR3 APOL3	9.75e-04	85	104	3	22q13.1
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	6.47e-08	92	70	7	521
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL2	2.19e-04	6	70	2	894
GeneFamily	PDZ domain containing	ARHGAP23 MAST2 MAST4 TJP3	2.86e-03	152	70	4	1220
GeneFamily	Apolipoproteins	APOL3 APOL4	2.96e-03	21	70	2	405
Coexpression	GSE17721_POLYIC_VS_PAM3CSK4_0.5H_BMDC_DN	RALGDS FBXO11 MAST2 PTOV1 MRM3 RASAL3 DENND4B TRPV4	1.19e-06	200	102	8	M3823
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN	GDF15 FBXO11 DUX4 MAST2 ADCY6 TAF6L LEFTY1 MAST4 TBC1D1 TLL2 EFCC1 DUX4L5 DUX4L6 DUX4L4 DUX4L7	2.36e-06	909	102	15	M41018
Drug	Moxisylyte hydrochoride [964-52-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A	HFE RALGDS NAAA GON4L ADCY6 BMP1 CACTIN SURF1 TJP3	2.94e-07	200	102	9	1682_DN
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; PC3; HT_HG-U133A	SIAH1 MAST2 TAF6L FBXO22 MAST4 SYNGR3 MMP11 TJP3	3.10e-06	198	102	8	3728_UP
Drug	MPBP	CYP2D7 CYP2D6 BMP1	4.81e-06	8	102	3	CID000129775
Drug	carvedilol	MPO CYP2D7 CYP2D6 MMP20 ADCY6 LEFTY1 MMP11	8.16e-06	161	102	7	CID000002585
Drug	cupreidine	CYP2D7 CYP2D6	1.99e-05	2	102	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	1.99e-05	2	102	2	CID000074866
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A	HFE RALGDS GDF15 TAF6L MAST4 LTBP2 MYO15A	2.47e-05	191	102	7	7417_UP
Drug	Furosemide [54-31-9]; Down 200; 12uM; MCF7; HT_HG-U133A	MPO RALGDS GON4L BMP1 MAST4 SLC2A6 ATL2	2.64e-05	193	102	7	3197_DN
Drug	Betaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	HFE RALGDS NAAA SIAH1 ADCY6 BMP1 ATL2	2.91e-05	196	102	7	5669_DN
Drug	Carisoprodol [78-44-4]; Down 200; 15.4uM; PC3; HT_HG-U133A	GABRR2 SP100 NAAA GON4L MAST2 CACTIN FAM210B	2.91e-05	196	102	7	6610_DN
Drug	Phthalylsulfathiazole [85-73-4]; Up 200; 10uM; HL60; HT_HG-U133A	GABRR2 COL17A1 TMEM8B DCC MAST2 FAM210B TJP3	3.11e-05	198	102	7	3033_UP
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; MCF7; HT_HG-U133A	HFE RALGDS KMT2B SIAH1 BMP1 SURF1 FAM210B	3.11e-05	198	102	7	6241_DN
Drug	Atracurium besylate [64228-81-5]; Down 200; 3.2uM; MCF7; HT_HG-U133A	GON4L TAF6L CACTIN SURF1 FAM210B SRRM2 TJP3	3.21e-05	199	102	7	1702_DN
Disease	Alzheimer's disease 1 (is_implicated_in)	MPO HFE	6.00e-05	4	94	2	DOID:0080348 (is_implicated_in)
Disease	solanidine measurement	CYP2D7 CYP2D6	6.00e-05	4	94	2	EFO_0800966
Disease	factor VIII measurement	RALGDS SLC2A6 RP1	2.84e-04	40	94	3	EFO_0004630
Disease	liver cirrhosis (is_implicated_in)	MPO HFE CENPC	3.52e-04	43	94	3	DOID:5082 (is_implicated_in)
Disease	Sideroblastic anemia	NDUFB11 GDF15	3.56e-04	9	94	2	C0002896
Disease	white matter hyperintensity measurement	AHCYL1 GON4L DCC ZNF831 TRPV4 PRDM15	4.19e-04	302	94	6	EFO_0005665
Disease	anemia (is_marker_for)	GDF15 TNFRSF1A	4.44e-04	10	94	2	DOID:2355 (is_marker_for)
Disease	Occupational Diseases	MPO CYP2D6	5.42e-04	11	94	2	C0028797
Disease	Cachexia	GDF15 TNFRSF1A	6.49e-04	12	94	2	C0006625
Disease	Mental Retardation, Psychosocial	RALGDS GON4L DCC SURF1	1.04e-03	139	94	4	C0025363
Disease	Profound Mental Retardation	RALGDS GON4L DCC SURF1	1.04e-03	139	94	4	C0020796
Disease	Mental deficiency	RALGDS GON4L DCC SURF1	1.04e-03	139	94	4	C0917816
Disease	low density lipoprotein cholesterol measurement, physical activity	HFE RP1 PRDM15	1.24e-03	66	94	3	EFO_0003940, EFO_0004611
Disease	Dystonia, Limb	KMT2B CYP2D6	1.32e-03	17	94	2	C0751093
Disease	a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement	SLC2A6 PRDM15	1.32e-03	17	94	2	EFO_0008011
Disease	Dystonia, Diurnal	KMT2B CYP2D6	1.32e-03	17	94	2	C0393610
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B SRRM2	1.32e-03	17	94	2	DOID:0060307 (is_implicated_in)
Disease	Dystonia, Paroxysmal	KMT2B CYP2D6	1.49e-03	18	94	2	C0393588
Disease	glomerulonephritis (is_marker_for)	MPO TNFRSF1A	1.66e-03	19	94	2	DOID:2921 (is_marker_for)
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	RYR3 ZNF669	2.65e-03	24	94	2	EFO_0006821, EFO_0006826
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	2.65e-03	24	94	2	EFO_0003761, EFO_0005658
Disease	hepatocellular carcinoma (is_implicated_in)	MPO HFE KMT2B RYR3	2.72e-03	181	94	4	DOID:684 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPINRWSPTRRRSRS	PRPF4B	431	Q13523
TRSTRETLLNPTWLR	UMODL1	661	Q5DID0
PLRARREVRSQHLSW	UMODL1-AS1	131	Q8N2C9
RRKSRLERWSPSVSR	nan	106	A8MUN3
EIRVRLQSASPSTRW	COL17A1	141	Q9UMD9
RLLEARSSRPTWIIQ	LINC00308	16	Q8TCZ7
APRAAERRSVIRSTW	B3GALT6	66	Q96L58
SQRVCRPRSIWRAKA	C8orf33	201	Q9H7E9
LERRVTGSTNRWRLP	BTBD16	11	Q32M84
VPRSGRSCWRRLVQV	ADCY6	111	O43306
RRSKATVGRPLIAWR	APOL4	251	Q9BPW4
RRRLVWTPSQSEALR	DUX4L4	21	P0CJ87
RWRVDVAISTSALAR	COMMD5	156	Q9GZQ3
RRRLVWTPSQSEALR	DUX4L6	21	P0CJ89
SRSRRAATSRPERVW	BMP1	116	P13497
RRPARRTQWLLSALA	EFCC1	21	Q9HA90
QSLRSVRRSESWARP	RASAL3	786	Q86YV0
WNRIRTSRRTIIHIP	IQCH	441	Q86VS3
IALRLRRSLSPATWD	PCDHGB6	711	Q9Y5F9
VRRVLRTHRSVTWIS	FBXO22	56	Q8NEZ5
VPVLVSSRFVRLSWR	DCC	436	P43146
LSPRSARARVTVEWL	LEFTY1	136	O75610
PIAFWARRASRTRLA	MAGED2	221	Q9UNF1
RRRLVWTPSQSEALR	DUX4	21	Q9UBX2
LRARSLLTPRRTRWL	NTSR2	141	O95665
RRHIPVSWLIRATLS	NAAA	211	Q02083
SPRASRRRAWSPLAS	MYO15A	761	Q9UKN7
RRRLVWTPSQSEALR	DUX4L3	21	P0CJ86
RSLWRRPFNVTDVLT	MPO	131	P05164
WRVDSRARPRVLTLC	NAT16	266	Q8N8M0
ARVRPRATWLLGATA	FAM210B	16	Q96KR6
TPLLRSRALVKRVTW	PHRF1	1391	Q9P1Y6
AVSTRIRWCRPDSRV	KRTAP1-5	111	Q9BYS1
VISWVTPRRRFITTK	LINGO2	441	Q7L985
TLRPAATARRKRRWA	HRES1	151	P13985
ATARRKRRWATRGPA	HRES1	156	P13985
ASRSWDVTRPLRRQL	GDF15	131	Q99988
RSILREPTFRWTSLT	KMT2B	601	Q9UMN6
RRDRVEPQSVSLSWR	EPHA10	461	Q5JZY3
RRVEPRTPWVSSRIS	HFE	66	Q30201
LRWASRLRAPTSTEA	NOP14	666	P78316
RRQSSRVSWAEARAP	SLC2A6	256	Q9UGQ3
PLVVRAVRSRSWPAS	PTOV1	26	Q86YD1
EAVAIVSTPRSQWRR	OTOP2	476	Q7RTS6
AVSRRRSEVRVPWLH	PLIN1	271	O60240
VARLSPETRERARSW	GAL3ST2	261	Q9H3Q3
TIIAITRFSRRKIPW	IGSF10	1191	Q6WRI0
TVTKSRRISRRPSDW	CENPC	516	Q03188
WVTTGSTPVLRRNRI	FBXO11	621	Q86XK2
PAWREQRRFSVSTLR	CYP2D6	126	P10635
RRRLVWTPSQSEALR	DUX4L9	21	Q6RFH8
LIRSRVSGWRAATAP	GALNT18	231	Q6P9A2
RWLPSSRARVKTRDR	GON4L	2076	Q3T8J9
GLWRRRRTSDPSAAV	ATL2	16	Q8NHH9
ARARARLPVTTWRIS	APOL3	301	O95236
RRRLVWTPSQSEALR	DUX4L7	21	P0CJ90
PRRWAERSPNLRRSS	LTBP2	236	Q14767
PGSRRSRSVWDAVRL	RALGDS	21	Q12967
ARRTDGRRWSLASLP	MAST2	221	Q6P0Q8
ARRTDGRRWSLASLP	MAST4	276	O15021
RASDASIRLPRWRTL	HUS1B	151	Q8NHY5
SIRLPRWRTLRSIVE	HUS1B	156	Q8NHY5
AVRSRRAIAVLSRWP	DENND4B	311	O75064
RRRRRARSWSPSSSA	CACTIN	101	Q8WUQ7
RRRLVWTPSQSEALR	DUX4L5	21	P0CJ88
RLRHPRERTALWVAT	COLGALT1	76	Q8NBJ5
FRRRWVGALASVTIP	MEST	261	Q5EB52
RVRWESSFSRTVVAP	NDUFB11	26	Q9NX14
VSFWIDRRAVPARVS	GABRR2	281	P28476
RSAPSWNTTVRLLRR	OTOF	1236	Q9HC10
RRRPRPWLSSRAISA	RP1	121	P56715
WRRQVHLRTGIRPST	MMP20	321	O60882
RRVDSPVPRRATDWR	MMP11	416	P24347
IGRTSRPARRWALSD	TAF6L	601	Q9Y6J9
PALATRRVARTQWLT	HHLA1	306	C9JL84
RSRSRTSPAPWKRSR	SRRM2	1851	Q9UQ35
SLSVRLSRPASWDRI	SLA2	131	Q9H6Q3
SARWRTAPVARTVSA	SSTR3	151	P32745
RSSRLPWAVAGRSRE	SCCPDH	36	Q8NBX0
PRRSTSSVRVRELSW	LRRC56	11	Q8IYG6
ARRWVRALRRSPVKV	MRM3	26	Q9HC36
VTSLRTPELTWERVR	AHCYL1	406	O43865
WISRSRSGIALRAAR	PRDM15	66	P57071
RRRLTWEATPRSIHE	SIAH1	231	Q8IUQ4
RRRLTWEATPRSIHD	SIAH2	271	O43255
AWPVLRSVNSRELSR	VHLL	41	Q6RSH7
ASAAWRSVLRVSPRP	SURF1	21	Q15526
PAWREQRRFSVSTLR	CYP2D7	126	A0A087X1C5
PSWRARRLSLSRSLV	ZC3H3	561	Q8IXZ2
SSWRRLVTLLNRPTD	GGCX	46	P38435
RSSRWPRESLSRSRQ	TTC24	556	A2A3L6
IRARRVSTSWSPVGA	MIPEP	31	Q99797
AGTRARSLWRVEPLR	RYR3	256	Q15413
TLPRRSRSWERAPRS	PLEKHG4B	76	Q96PX9
PLSPETRRRRSSWRR	ARHGAP23	1391	Q9P227
RSTSTWRIPSRKRRF	SP100	436	P23497
PWVVAEVRRLSRQST	TBC1D1	41	Q86TI0
WLRRVRRSRSQTPSC	nan	36	A6NN06
RVRRATTSRTERIWP	TLL2	146	Q9Y6L7
ILATAWTVRSVRRRH	TMEM8B	356	A6NDV4
ARRPQTLLRVASWVF	SYNGR3	21	O43761
WLRRVRRSRSQTPSC	nan	36	Q5XG85
LIRARSPAWPRRAVS	nan	21	Q8N1X5
ERRRATIRPWSTFVD	RABAC1	36	Q9UI14
WLRRVRRSRSQTPSY	nan	36	Q5VV11
QWLAPASRRSTRRLY	TJP3	711	O95049
CVQLRASRLRTPTWV	ZNF831	1301	Q5JPB2
ASRLRTPTWVRRRSR	ZNF831	1306	Q5JPB2
TWRRRTPRREATLEL	TNFRSF1A	406	P19438
RLRRDRWSSVVPRVV	TRPV4	816	Q9HBA0
LRNLRTESPWRSRGS	ZNF669	31	Q96BR6
RIRAQVPDTRWSRVG	UNQ9165/PRO28630	76	Q6UXU0
RRRLVWTPSQSEALR	DUX4L2	21	P0CJ85
VEGSRPWAVARRVLT	KEL	36	P23276