Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnatural killer cell lectin-like receptor binding

RAET1G ULBP2 RAET1L

4.97e-0617403GO:0046703
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5D KDM5C

5.84e-056402GO:0034647
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5D KDM5C

1.09e-048402GO:0032453
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate binding

OBSCN ASAP1 SVIL

9.07e-0495403GO:0005546
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5D KDM5C

1.43e-0328402GO:0141052
GeneOntologyMolecularFunctionadenylyltransferase activity

OAS2 TENT4B

1.75e-0331402GO:0070566
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5D KDM5C

1.75e-0331402GO:0032452
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate binding

OBSCN ASAP1 SVIL

1.82e-03121403GO:1902936
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5D KDM5C

1.87e-0332402GO:0140457
GeneOntologyBiologicalProcesssusceptibility to natural killer cell mediated cytotoxicity

RAET1G ULBP2 RAET1L

5.63e-079403GO:0042271
GeneOntologyBiologicalProcesspositive regulation of macrophage activation

RAET1G ULBP2 RAET1L LGALS9

1.29e-0642404GO:0043032
GeneOntologyBiologicalProcesspositive regulation of type II interferon production

RAET1G ULBP2 IL12RB2 RAET1L LGALS9

1.61e-06103405GO:0032729
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

RAET1G ULBP2 RAET1L

3.72e-0616403GO:0002486
GeneOntologyBiologicalProcessnatural killer cell activation

RAET1G IL11RA ULBP2 RAET1L LGALS9

4.03e-06124405GO:0030101
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

RAET1G ULBP2 RAET1L

4.51e-0617403GO:0002484
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class Ib

RAET1G ULBP2 RAET1L

4.51e-0617403GO:0002476
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen via MHC class Ib

RAET1G ULBP2 RAET1L

5.40e-0618403GO:0002428
GeneOntologyBiologicalProcessregulation of natural killer cell activation

RAET1G ULBP2 RAET1L LGALS9

5.84e-0661404GO:0032814
GeneOntologyBiologicalProcesscellular response to exogenous dsRNA

RAET1G ULBP2 RAET1L

1.01e-0522403GO:0071360
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class I

RAET1G ULBP2 RAET1L

1.16e-0523403GO:0019885
GeneOntologyBiologicalProcessregulation of type II interferon production

RAET1G ULBP2 IL12RB2 RAET1L LGALS9

1.20e-05155405GO:0032649
GeneOntologyBiologicalProcessregulation of natural killer cell mediated cytotoxicity

RAET1G ULBP2 RAET1L LGALS9

1.41e-0576404GO:0042269
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen

RAET1G ULBP2 RAET1L

1.51e-0525403GO:0002483
GeneOntologyBiologicalProcessantigen processing and presentation via MHC class Ib

RAET1G ULBP2 RAET1L

1.51e-0525403GO:0002475
GeneOntologyBiologicalProcessregulation of natural killer cell mediated immunity

RAET1G ULBP2 RAET1L LGALS9

1.72e-0580404GO:0002715
GeneOntologyBiologicalProcessregulation of macrophage activation

RAET1G ULBP2 RAET1L LGALS9

1.81e-0581404GO:0043030
GeneOntologyBiologicalProcesstype II interferon production

RAET1G ULBP2 IL12RB2 RAET1L LGALS9

1.82e-05169405GO:0032609
GeneOntologyBiologicalProcesspositive regulation of response to tumor cell

RAET1G ULBP2 RAET1L

2.14e-0528403GO:0002836
GeneOntologyBiologicalProcesspositive regulation of immune response to tumor cell

RAET1G ULBP2 RAET1L

2.14e-0528403GO:0002839
GeneOntologyBiologicalProcesscellular response to dsRNA

RAET1G ULBP2 RAET1L

2.14e-0528403GO:0071359
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous antigen

RAET1G ULBP2 RAET1L

3.22e-0532403GO:0019883
GeneOntologyBiologicalProcesspositive regulation of natural killer cell activation

RAET1G ULBP2 RAET1L

4.24e-0535403GO:0032816
GeneOntologyBiologicalProcessnatural killer cell mediated cytotoxicity

RAET1G ULBP2 RAET1L LGALS9

5.03e-05105404GO:0042267
GeneOntologyBiologicalProcessnatural killer cell mediated immunity

RAET1G ULBP2 RAET1L LGALS9

5.82e-05109404GO:0002228
GeneOntologyBiologicalProcesspositive regulation of natural killer cell mediated cytotoxicity

RAET1G ULBP2 RAET1L

6.35e-0540403GO:0045954
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen via MHC class I

RAET1G ULBP2 RAET1L

6.84e-0541403GO:0002474
GeneOntologyBiologicalProcesspositive regulation of T cell mediated cytotoxicity

RAET1G ULBP2 RAET1L

7.36e-0542403GO:0001916
GeneOntologyBiologicalProcesspositive regulation of natural killer cell mediated immunity

RAET1G ULBP2 RAET1L

8.47e-0544403GO:0002717
GeneOntologyBiologicalProcessregulation of leukocyte mediated cytotoxicity

RAET1G ULBP2 RAET1L LGALS9

9.62e-05124404GO:0001910
GeneOntologyBiologicalProcessregulation of immune response to tumor cell

RAET1G ULBP2 RAET1L

1.17e-0449403GO:0002837
GeneOntologyBiologicalProcessregulation of response to tumor cell

RAET1G ULBP2 RAET1L

1.24e-0450403GO:0002834
GeneOntologyBiologicalProcessregulation of T cell mediated cytotoxicity

RAET1G ULBP2 RAET1L

1.48e-0453403GO:0001914
GeneOntologyBiologicalProcessantigen processing and presentation

RAET1G ULBP2 RAET1L KDM5D

1.50e-04139404GO:0019882
GeneOntologyBiologicalProcessmacrophage activation

RAET1G ULBP2 RAET1L LGALS9

1.54e-04140404GO:0042116
GeneOntologyBiologicalProcessresponse to exogenous dsRNA

RAET1G ULBP2 RAET1L

1.65e-0455403GO:0043330
GeneOntologyBiologicalProcessimmune response to tumor cell

RAET1G ULBP2 RAET1L

1.74e-0456403GO:0002418
GeneOntologyBiologicalProcessregulation of cell killing

RAET1G ULBP2 RAET1L LGALS9

1.85e-04147404GO:0031341
GeneOntologyBiologicalProcesslymphocyte mediated immunity

RAET1G ULBP2 RAET1L KDM5D CD19 LGALS9

2.11e-04449406GO:0002449
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

RAET1G ULBP2 RAET1L KDM5D CD19 LGALS9

2.46e-04462406GO:0002460
GeneOntologyBiologicalProcessresponse to dsRNA

RAET1G ULBP2 RAET1L

2.48e-0463403GO:0043331
GeneOntologyBiologicalProcessmulti-multicellular organism process

IL11RA TBXT ITGA3 HYAL3 LGALS9

2.49e-04294405GO:0044706
GeneOntologyBiologicalProcesspositive regulation of nitric oxide biosynthetic process

RAET1G ULBP2 RAET1L

2.72e-0465403GO:0045429
GeneOntologyBiologicalProcessT cell mediated immunity

RAET1G ULBP2 RAET1L KDM5D

2.75e-04163404GO:0002456
GeneOntologyBiologicalProcesspenetration of zona pellucida

TBXT HYAL3

2.82e-0413402GO:0007341
GeneOntologyBiologicalProcesspositive regulation of nitric oxide metabolic process

RAET1G ULBP2 RAET1L

2.97e-0467403GO:1904407
GeneOntologyBiologicalProcessT cell mediated cytotoxicity

RAET1G ULBP2 RAET1L

3.38e-0470403GO:0001913
GeneOntologyBiologicalProcessresponse to tumor cell

RAET1G ULBP2 RAET1L

3.52e-0471403GO:0002347
GeneOntologyBiologicalProcessmaternal process involved in female pregnancy

IL11RA ITGA3 LGALS9

3.82e-0473403GO:0060135
GeneOntologyBiologicalProcesspositive regulation of T cell mediated immunity

RAET1G ULBP2 RAET1L

3.98e-0474403GO:0002711
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen

RAET1G ULBP2 RAET1L

4.31e-0476403GO:0048002
GeneOntologyBiologicalProcessleukocyte mediated cytotoxicity

RAET1G ULBP2 RAET1L LGALS9

4.63e-04187404GO:0001909
GeneOntologyBiologicalProcesspositive regulation of leukocyte mediated cytotoxicity

RAET1G ULBP2 RAET1L

4.82e-0479403GO:0001912
GeneOntologyBiologicalProcessnegative regulation of dendritic spine development

FSTL4 ASAP1

5.50e-0418402GO:0061000
GeneOntologyBiologicalProcesspositive regulation of cell killing

RAET1G ULBP2 RAET1L

6.61e-0488403GO:0031343
GeneOntologyBiologicalProcessleukocyte mediated immunity

RAET1G ULBP2 RAET1L KDM5D CD19 LGALS9

7.91e-04576406GO:0002443
GeneOntologyBiologicalProcesspositive regulation of cytokine production

RAET1G ULBP2 IL12RB2 OAS2 RAET1L LGALS9

8.65e-04586406GO:0001819
GeneOntologyBiologicalProcessregulation of nitric oxide biosynthetic process

RAET1G ULBP2 RAET1L

8.78e-0497403GO:0045428
GeneOntologyBiologicalProcessregulation of nitric oxide metabolic process

RAET1G ULBP2 RAET1L

9.59e-04100403GO:0080164
GeneOntologyBiologicalProcessregulation of lymphocyte mediated immunity

RAET1G ULBP2 RAET1L LGALS9

1.04e-03232404GO:0002706
GeneOntologyBiologicalProcessdefense response to bacterium

RAET1G ULBP2 OAS2 RAET1L LGALS9

1.06e-03405405GO:0042742
GeneOntologyBiologicalProcessregulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

RAET1G ULBP2 RAET1L LGALS9

1.09e-03235404GO:0002822
GeneOntologyBiologicalProcessregulation of T cell mediated immunity

RAET1G ULBP2 RAET1L

1.30e-03111403GO:0002709
GeneOntologyBiologicalProcessnitric oxide biosynthetic process

RAET1G ULBP2 RAET1L

1.33e-03112403GO:0006809
GeneOntologyBiologicalProcessregulation of adaptive immune response

RAET1G ULBP2 RAET1L LGALS9

1.41e-03252404GO:0002819
GeneOntologyBiologicalProcessnitric oxide metabolic process

RAET1G ULBP2 RAET1L

1.66e-03121403GO:0046209
GeneOntologyBiologicalProcessreactive nitrogen species metabolic process

RAET1G ULBP2 RAET1L

1.74e-03123403GO:2001057
GeneOntologyBiologicalProcessresponse to lipopolysaccharide

RAET1G ULBP2 IL12RB2 RAET1L LGALS9

1.94e-03464405GO:0032496
GeneOntologyBiologicalProcessnatural killer cell differentiation

IL11RA LGALS9

2.47e-0338402GO:0001779
GeneOntologyBiologicalProcessresponse to molecule of bacterial origin

RAET1G ULBP2 IL12RB2 RAET1L LGALS9

2.48e-03491405GO:0002237
GeneOntologyCellularComponentside of membrane

MMP25 RAET1G IL11RA ULBP2 IL12RB2 RAET1L EFNA2 ITGA3 CD19

2.58e-05875399GO:0098552
GeneOntologyCellularComponentexternal side of plasma membrane

RAET1G IL11RA ULBP2 IL12RB2 RAET1L ITGA3 CD19

4.31e-05519397GO:0009897
GeneOntologyCellularComponentcell surface

MMP25 RAET1G IL11RA ULBP2 IL12RB2 RAET1L ITGA3 CD19

8.74e-041111398GO:0009986
DomainMHC_I

RAET1G ULBP2 RAET1L

1.27e-0521413PF00129
DomainMHC_I_a_a1/a2

RAET1G ULBP2 RAET1L

1.27e-0521413IPR001039
Domain-

RAET1G ULBP2 RAET1L

1.92e-05244133.30.500.10
DomainMHC_I-like_Ag-recog

RAET1G ULBP2 RAET1L

1.92e-0524413IPR011161
DomainLys_sp_deMease-like_dom

KDM5D KDM5C

2.81e-054412IPR013637
DomainPLU-1

KDM5D KDM5C

2.81e-054412PF08429
Domainzf-C5HC2

KDM5D KDM5C

4.68e-055412PF02928
DomainZnf_C5HC2

KDM5D KDM5C

4.68e-055412IPR004198
DomainMHC_I/II-like_Ag-recog

RAET1G ULBP2 RAET1L

7.85e-0538413IPR011162
DomainJmjN

KDM5D KDM5C

2.09e-0410412SM00545
DomainJMJN

KDM5D KDM5C

2.09e-0410412PS51183
DomainJmjN

KDM5D KDM5C

2.09e-0410412PF02375
DomainJmjN

KDM5D KDM5C

2.09e-0410412IPR003349
DomainNTP_transf_2

OAS2 TENT4B

2.55e-0411412PF01909
DomainPolymerase_NTP_transf_dom

OAS2 TENT4B

2.55e-0411412IPR002934
DomainIG_MHC

RAET1G ULBP2 RAET1L

3.08e-0460413PS00290
Domain-

KDM5D KDM5C

4.85e-04154121.10.150.60
DomainBRIGHT

KDM5D KDM5C

4.85e-0415412SM00501
DomainARID_dom

KDM5D KDM5C

4.85e-0415412IPR001606
DomainARID

KDM5D KDM5C

4.85e-0415412PS51011
DomainARID

KDM5D KDM5C

4.85e-0415412PF01388
DomainJmjC

KDM5D KDM5C

1.26e-0324412PF02373
DomainJMJC

KDM5D KDM5C

2.24e-0332412PS51184
DomainJmjC_dom

KDM5D KDM5C

2.24e-0332412IPR003347
DomainJmjC

KDM5D KDM5C

2.38e-0333412SM00558
DomainCYSTEINE_SWITCH

MMP25 ADAMTS19

3.65e-0341412PS00546
DomainPept_M10_metallopeptidase

MMP25 ADAMTS19

4.01e-0343412IPR001818
Domainfn3

OBSCN IL11RA IL12RB2

5.36e-03162413PF00041
DomainIg/MHC_CS

RAET1G ULBP2

7.19e-0358412IPR003006
DomainFN3

OBSCN IL11RA IL12RB2

7.73e-03185413SM00060
Domainig

OBSCN FSTL4 IL11RA

8.32e-03190413PF00047
DomainImmunoglobulin

OBSCN FSTL4 IL11RA

8.32e-03190413IPR013151
DomainTSP_1

ADAMTS19 SEMA5B

8.44e-0363412PF00090
DomainTSP1

ADAMTS19 SEMA5B

8.96e-0365412SM00209
DomainTSP1_rpt

ADAMTS19 SEMA5B

8.96e-0365412IPR000884
DomainTSP1

ADAMTS19 SEMA5B

8.96e-0365412PS50092
DomainZinc_finger_PHD-type_CS

KDM5D KDM5C

8.96e-0365412IPR019786
DomainFN3

OBSCN IL11RA IL12RB2

9.43e-03199413PS50853
DomainFN3_dom

OBSCN IL11RA IL12RB2

1.08e-02209413IPR003961
Pubmed

Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.

RAET1G ULBP2 RAET1L

2.02e-09345325212604
Pubmed

NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.

RAET1G ULBP2 RAET1L

8.09e-09445312756263
Pubmed

Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.

RAET1G ULBP2 RAET1L

8.09e-09445320166740
Pubmed

Murine NKG2D ligands: "double, double toil and trouble".

RAET1G ULBP2 RAET1L

8.09e-09445319081632
Pubmed

Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules.

RAET1G ULBP2 RAET1L

8.09e-0944538882725
Pubmed

Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin.

RAET1G ULBP2 RAET1L

8.09e-09445312421908
Pubmed

MULT1E/mIL-12: a novel bifunctional protein for natural killer cell activation.

RAET1G ULBP2 RAET1L

2.02e-08545324572784
Pubmed

Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain.

RAET1G ULBP2 RAET1L

2.02e-0854538982867
Pubmed

Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D.

RAET1G ULBP2 RAET1L

4.04e-08645311825567
Pubmed

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.

RAET1G ULBP2 RAET1L

4.04e-08645320219610
Pubmed

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

RAET1G ULBP2 RAET1L

4.04e-08645310894171
Pubmed

Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.

RAET1G ULBP2 RAET1L

4.04e-08645319688209
Pubmed

The NKG2D ligands RAE-1δ and RAE-1ε differ with respect to their receptor affinity, expression profiles and transcriptional regulation.

RAET1G ULBP2 RAET1L

4.04e-08645320976056
Pubmed

Ligands for murine NKG2D display heterogeneous binding behavior.

RAET1G ULBP2 RAET1L

4.04e-08645311857333
Pubmed

The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.

RAET1G ULBP2 RAET1L

7.06e-08745316831899
Pubmed

Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase.

RAET1G ULBP2 RAET1L

7.06e-08745320870941
Pubmed

Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma.

RAET1G ULBP2 RAET1L

7.06e-08745326151313
Pubmed

NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis.

RAET1G ULBP2 RAET1L

7.06e-08745330787931
Pubmed

Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.

RAET1G ULBP2 RAET1L

7.06e-08745312370332
Pubmed

NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.

RAET1G ULBP2 RAET1L

7.06e-08745325583577
Pubmed

A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity.

RAET1G ULBP2 RAET1L

1.13e-07845312645935
Pubmed

Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells.

RAET1G ULBP2 RAET1L

1.69e-07945323136011
Pubmed

Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor.

RAET1G ULBP2 RAET1L

1.69e-07945314764662
Pubmed

A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.

RAET1G ULBP2 RAET1L

2.41e-071045311827464
Pubmed

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles.

RAET1G ULBP2 RAET1L

3.32e-071145326656785
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5D KDM5C

1.64e-06245232081420
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5D KDM5C

1.64e-0624529060413
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5D KDM5C

1.64e-06245210441747
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5D KDM5C

1.64e-06245216416087
Pubmed

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

KDM5D KDM5C

1.64e-0624527524912
Pubmed

Identification of a mouse male-specific transplantation antigen, H-Y.

KDM5D KDM5C

4.91e-0634527544442
Pubmed

The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation.

CD19 FASTK

4.91e-06345230232138
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5D KDM5C

9.81e-06445216541399
Pubmed

X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.

KDM5D KDM5C

9.81e-06445232732223
Pubmed

A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.

KDM5D KDM5C

9.81e-0644527951230
Pubmed

Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain.

RAET1G ULBP2

9.81e-06445219424970
Pubmed

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

KDM5D KDM5C

9.81e-06445217320160
Pubmed

ULBP6/RAET1L is an additional human NKG2D ligand.

RAET1G RAET1L

1.63e-05545219658097
Pubmed

IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression.

IL12RB2 CD19

1.63e-05545231775046
Pubmed

CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells.

ULBP2 CD19

1.63e-05545227477692
Pubmed

A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.

ULBP2 RAET1L

3.42e-05745228559451
Pubmed

Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1.

TBXT EFNA2

3.42e-05745211287184
Pubmed

The composition and signaling of the IL-35 receptor are unconventional.

IL11RA IL12RB2

5.86e-05945222306691
Pubmed

Basement membrane remodelling regulates mouse embryogenesis.

MMP25 TBXT

8.94e-051145232523119
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KDM5D KDM5C

1.27e-041345224619213
Pubmed

Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.

KDM5D KDM5C

1.27e-041345214660691
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS19 TBXT SEMA5B

1.28e-047545320637190
Pubmed

The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate.

TBXT SHROOM3

1.70e-041545229636380
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

KDM5D KDM5C

1.70e-041545214762062
Pubmed

Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate.

GCM1 KDM5C

2.20e-041745219716815
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

KDM5D KDM5C

2.47e-041845212023983
Pubmed

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.

SEMA5B KDM5C

3.06e-042045223637629
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

FSTL4 ANKHD1 ZFR2

3.36e-0410445310470851
Pubmed

Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation.

GCM1 KDM5C

4.07e-042345222573614
Pubmed

Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis.

TBXT SEMA5B

4.44e-042445237414952
Pubmed

Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.

GCM1 TBXT

4.82e-042545219786569
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

OBSCN SHROOM3 EFNA2 LTK MAN2A2 ITGA3 ANKHD1

5.07e-04110545735748872
Pubmed

The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing.

TBXT LGALS9

5.63e-042745236197846
Pubmed

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

MAN2A2 CSMD2

6.06e-042845218839057
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5D KDM5C

8.43e-043345226864203
Pubmed

Sexually dimorphic gene expression in the developing mouse gonad.

ADAMTS19 KDM5D

9.48e-043545212617826
CytobandEnsembl 112 genes in cytogenetic band chr6q25

RAET1G ULBP2 RAET1L

5.32e-04164443chr6q25
Cytoband17q21.33

ITGA3 H1-9P

7.19e-044144217q21.33
Cytoband17q25.3

LINC00482 GALR2

4.27e-0310144217q25.3
GeneFamilyAT-rich interaction domain containing

KDM5D KDM5C

2.40e-0415282418
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5D KDM5C

6.25e-0424282485
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL11RA IL12RB2

1.92e-0342282602
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

KDM5D CD19

2.81e-0351282870
GeneFamilyImmunoglobulin like domain containing

FSTL4 IL11RA CD19

3.22e-03193283594
GeneFamilyPHD finger proteins

KDM5D KDM5C

8.52e-039028288
GeneFamilyFibronectin type III domain containing

OBSCN IL12RB2

2.53e-02160282555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

OBSCN FSTL4

2.56e-02161282593
CoexpressionGSE11864_UNTREATED_VS_CSF1_IN_MAC_UP

KIAA0040 UBA7 ANKHD1 FASTK SVIL

1.70e-05196435M3122
ToppCell(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

FSTL4 FRY SHROOM3 LTK ITGA3

5.30e-0715745584f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FSTL4 FRY SHROOM3 ITGA3

2.60e-05170454054360a3b05f5e41221c98b122d241b1affad26a
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FSTL4 FRY SHROOM3 ITGA3

2.60e-05170454f0b0d2d0402de3ed7322284a599646db43475761
ToppCellTCGA-Cervix|World / Sample_Type by Project: Shred V9

BRME1 ULBP2 ZFR2 PRSS36

2.60e-05170454a6cbe253bc60f5d5cb361c7e85ed9928a3155ec8
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

KIAA0040 OAS2 CD19 LGALS9

3.46e-05183454dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ULBP2 FRY C1orf167 LGALS9

3.69e-05186454055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCellControl-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

FSTL4 FRY LTK ITGA3

3.85e-0518845488b3415e33db81726dd29c1f50c886e057af50a0
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FSTL4 FRY LTK ITGA3

3.93e-05189454b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

OBSCN FSTL4 LTK ITGA3

4.01e-051904540a351609a72fd638c84b2435782e312ee6a33aac
ToppCelldroplet-Skin-nan-21m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL11RA KIAA0040 ITGA3 LGALS9

4.01e-05190454c1bfc1960a3df49c0f459454a7363804c32418ee
ToppCellwk_08-11-Hematologic-Myeloid-Myelocyte-like|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MMP25 BRME1 FRY TENT4B

4.53e-051964544b88c96b737a747422674ad99c073b28e6febc7c
ToppCellwk_08-11-Mesenchymal-Fibroblast-Adventitial_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

IL11RA ADAMTS19 SEMA5B SVIL

4.53e-05196454eed9fe83ffc1f79493b70778962a671dd9f481e0
ToppCell11.5-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

ULBP2 OAS2 FRY LGALS9

4.53e-05196454509ddea8d6e1d0b832f69490ab8a736af4ca19a8
ToppCell11.5-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

ULBP2 OAS2 FRY LGALS9

4.53e-05196454e7d55933e23599122e20498548abf5b30fc25c8f
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SHROOM3 C1orf167 ITGA3 ABCC6

4.80e-05199454aca81a879ef9c196bd1885eff4c63ffe6c9682b7
ToppCelldistal-Endothelial-Capillary_Aerocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FSTL4 FRY LTK ITGA3

4.89e-05200454d36236c7703b759309c8347f44900fc4bed377f0
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

OBSCN MMP25 ABCC6

8.42e-058445343e77117579290446a7e386c0be3459d652d9384
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

OBSCN MMP25 ABCC6

8.42e-058445338a457a20701fe23c6326b7282cd0993cdd87082
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

OBSCN MMP25 ABCC6

8.42e-058445359d0415bb6b6b18a94d2c9c6289fa9cbcb2166e3
Drug2-[amino-[(2R,3R)-4-(dibenzylamino)-3-hydroxy-4-oxo-2-sulfanylbutanoyl]amino]acetic acid

IL12RB2 KDM5D CD19 ABCC6

6.96e-0737434CID016040231
Drugcox-2 inhibitor I; Up 200; 10uM; MCF7; HG-U133A

BRME1 GCM1 LTK CD19 ABCC6 ZFR2

1.76e-06196436253_UP
DrugAC1NSE8A

TBXT UBA7

1.04e-053432CID005359815
DrugAZFd

KDM5D CD19 KDM5C

1.08e-0523433CID000196489
Drugradicicol; Down 200; 0.1uM; PC3; HG-U133A

BRME1 TBXT MAN2A2 KDM5D ZFR2

3.56e-05199435484_DN
Diseaselevel of UL16-binding protein 6 in blood serum

ULBP2 RAET1L

1.98e-062422OBA_2043185
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5D KDM5C

1.18e-054422DOID:0060809 (implicated_via_orthology)
Diseasemagnesium measurement

ADAMTS19 SHROOM3 ASAP1

1.15e-0466423EFO_0004845
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5D KDM5C

2.34e-0416422DOID:0050888 (implicated_via_orthology)
DiseaseNeural Tube Defects

TBXT SHROOM3

8.39e-0430422C0027794
Diseaseright ventricular ejection fraction measurement

OBSCN SVIL

8.39e-0430422EFO_0021816
Diseasecreatine measurement

FSTL4 ASAP1

1.21e-0336422EFO_0010472
Diseaseintellectual disability (implicated_via_orthology)

KDM5D KDM5C

5.14e-0375422DOID:1059 (implicated_via_orthology)
Diseasealbuminuria

SHROOM3 LTK

7.96e-0394422EFO_0004285
DiseaseDepressive disorder

OAS2 CSMD2 GALR2

8.05e-03289423C0011581

Protein segments in the cluster

PeptideGeneStartEntry
CQAPQEPPAWGVSPK

C1orf167

446

Q5SNV9
GPDGKPVWNNPRPVC

CSMD2

1601

Q7Z408
PPHWGPQRGPRNAAA

ASB16-AS1

46

Q495Z4
QVRAGWACPGQDPGP

ACTR5

41

Q9H9F9
WACPGQDPGPEPRLQ

ACTR5

46

Q9H9F9
ENPPCPAGLPGFRDW

ADAMTS19

681

Q8TE59
QWGLKNRPEPSCNGP

TENT4B

431

Q8NDF8
PPVQPCCLGPSKWGD

FASTK

56

Q14296
DAPQPMGPNWLDCPA

MMP25

496

Q9NPA2
CPQAWGPPGVQYGQP

IL11RA

26

Q14626
GPWPCPQDPLGAARC

IL11RA

166

Q14626
CWSPPGKRGQQPEKN

KIAA0040

51

Q15053
GRRQKPPGVWPANPA

LGALS9

176

O00182
PPCSNWPQREKGIQG

IL12RB2

721

Q99665
SGICKIRPPADWQPP

KDM5D

41

Q9BY66
CQVGLGPAQSWPLPP

LTK

486

P29376
NGSWPCRPPGDLINP

ITGA3

841

P26006
AARPVPGAPVPQGAW

GOLGA6L19

486

H0YKK7
QKPPCRGGCWGQPGH

PRR25

6

Q96S07
SPCFKDGTGNPIPPW

OAS2

666

P29728
SPWGQPAPFCHPKQG

OBSCN

7026

Q5VST9
ALPECGKAPRPGAWP

PRSS36

321

Q5K4E3
PCPGPSWQGPKAGDS

GALR2

366

O43603
SACKCPRKGPNPGPW

LINC00482

191

Q8N8I6
QLFPSGNKPGPCWPG

BRME1

556

Q0VDD7
LCQPGPPSEKAWQPG

CD19

96

P15391
NLKEPPAGPAQPWGG

FSTL4

776

Q6MZW2
GCPPLWPNPAGNLYE

GCM1

351

Q9NP62
WAGPTCQEPRPGPKE

HYAL3

401

O43820
PHGPPNKGAVPWGND

ASAP1

846

Q9ULH1
PGGRINCPWKVPPRA

MAN2A2

376

P49641
RWECNRPAAPGGPLK

EFNA2

111

O43921
KQPQPLPMPCTGGCW

FRY

1606

Q5TBA9
PTPAPRAQVCGGQPW

H1-9P

41

P60008
CNPLIPRKGQGRPDW

SVIL

1646

O95425
PTCAAQPPWPQGGQI

ABCC6

1251

O95255
PRGKGVPPPSWSQQC

SHROOM3

351

Q8TF72
NTWGPFPVRPVNPGN

ANKHD1

1886

Q8IWZ3
PPEPQAAGCRPQWGK

ZFR2

406

Q9UPR6
GTPFWSGPKQCPQPL

UBA7

701

P41226
PKFRPGPRWCAVQGQ

RAET1G

41

Q6H3X3
NGEWVPGGKPEPQAP

TBXT

106

O15178
PKFRPGPRWCAVQGQ

RAET1L

41

Q5VY80
PGPPDTPAQQLRCGW

SEMA5B

16

Q9P283
GKEPCNWRRPGPKIP

ZNF746

151

Q6NUN9
PKFRPGPRWCAVQGQ

ULBP2

41

Q9BZM5
SGICKIRPPADWQPP

KDM5C

41

P41229