Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX1 SOX2 RFX2 BNC1 SOX15 SOX14 VENTX SOX21	8.93e-08	566	22	8	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX1 SOX2 RFX2 SOX15 SOX14 VENTX SOX21	1.55e-06	560	22	7	GO:0001228
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX1 SOX2 RFX2 SOX15 SOX14 VENTX SOX21	2.66e-04	1244	22	7	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX1 SOX2 RFX2 SOX15 SOX14 VENTX SOX21	3.04e-04	1271	22	7	GO:0000987
GeneOntologyMolecularFunction	protein transmembrane transporter activity	SEC61A1 SEC61A2	4.30e-04	28	22	2	GO:0008320
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX1 SOX2 RFX2 SOX15 SOX14 VENTX SOX21	5.77e-04	1412	22	7	GO:0000981
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	SEC61A1 SEC61A2	6.36e-04	34	22	2	GO:0022884
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX1 SOX2 RFX2 SOX15 SOX14 VENTX SOX21	7.03e-04	1459	22	7	GO:0000977
GeneOntologyMolecularFunction	protein transporter activity	SEC61A1 SEC61A2	9.71e-04	42	22	2	GO:0140318
GeneOntologyMolecularFunction	signal sequence binding	SEC61A1 SEC61A2	1.43e-03	51	22	2	GO:0005048
GeneOntologyMolecularFunction	peptide binding	APBA2 SEC61A1 SEC61A2	4.92e-03	318	22	3	GO:0042277
GeneOntologyMolecularFunction	ribosome binding	SEC61A1 SEC61A2	7.65e-03	120	22	2	GO:0043022
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SOX1 SOX2 RFX2 SOX15 AKAP8L SOX14 PRDM10 VENTX SOX21	3.91e-06	1390	21	9	GO:0045944
GeneOntologyBiologicalProcess	SRP-dependent cotranslational protein targeting to membrane, translocation	SEC61A1 SEC61A2	2.75e-05	8	21	2	GO:0006616
GeneOntologyBiologicalProcess	post-translational protein targeting to membrane, translocation	SEC61A1 SEC61A2	2.75e-05	8	21	2	GO:0031204
GeneOntologyBiologicalProcess	post-translational protein targeting to endoplasmic reticulum membrane	SEC61A1 SEC61A2	2.05e-04	21	21	2	GO:0006620
GeneOntologyBiologicalProcess	SRP-dependent cotranslational protein targeting to membrane	SEC61A1 SEC61A2	3.41e-04	27	21	2	GO:0006614
GeneOntologyBiologicalProcess	lens morphogenesis in camera-type eye	SOX1 SOX2	3.67e-04	28	21	2	GO:0002089
GeneOntologyBiologicalProcess	intracellular protein transmembrane transport	SEC61A1 SEC61A2	4.51e-04	31	21	2	GO:0065002
GeneOntologyBiologicalProcess	cotranslational protein targeting to membrane	SEC61A1 SEC61A2	4.81e-04	32	21	2	GO:0006613
GeneOntologyBiologicalProcess	central nervous system development	SOX1 SOX2 SOX15 SOX14 PTPRA SOX21	9.62e-04	1197	21	6	GO:0007417
GeneOntologyBiologicalProcess	developmental process involved in reproduction	MNS1 SOX2 BRDT RFX2 BNC1 SOX15	1.13e-03	1235	21	6	GO:0003006
GeneOntologyBiologicalProcess	protein targeting to ER	SEC61A1 SEC61A2	1.27e-03	52	21	2	GO:0045047
GeneOntologyBiologicalProcess	germ cell development	MNS1 BRDT RFX2 BNC1	1.29e-03	482	21	4	GO:0007281
GeneOntologyBiologicalProcess	forebrain neuron differentiation	SOX1 SOX2	1.32e-03	53	21	2	GO:0021879
GeneOntologyBiologicalProcess	brain development	SOX1 SOX2 SOX15 SOX14 SOX21	1.44e-03	859	21	5	GO:0007420
GeneOntologyBiologicalProcess	establishment of protein localization to endoplasmic reticulum	SEC61A1 SEC61A2	1.47e-03	56	21	2	GO:0072599
GeneOntologyBiologicalProcess	regulation of oligodendrocyte differentiation	SOX1 PTPRA	1.58e-03	58	21	2	GO:0048713
GeneOntologyBiologicalProcess	cellular process involved in reproduction in multicellular organism	MNS1 BRDT RFX2 BNC1	1.78e-03	527	21	4	GO:0022412
GeneOntologyBiologicalProcess	head development	SOX1 SOX2 SOX15 SOX14 SOX21	1.95e-03	919	21	5	GO:0060322
GeneOntologyBiologicalProcess	forebrain generation of neurons	SOX1 SOX2	1.98e-03	65	21	2	GO:0021872
GeneOntologyBiologicalProcess	spermatid development	MNS1 BRDT RFX2	2.28e-03	262	21	3	GO:0007286
GeneOntologyCellularComponent	chromatin	SOX1 SOX2 BRDT RFX2 SOX15 AKAP8L SOX14 PRDM10 VENTX SOX21	5.26e-07	1480	21	10	GO:0000785
GeneOntologyCellularComponent	Sec61 translocon complex	SEC61A1 SEC61A2	9.59e-06	5	21	2	GO:0005784
GeneOntologyCellularComponent	translocon complex	SEC61A1 SEC61A2	1.44e-05	6	21	2	GO:0071256
GeneOntologyCellularComponent	rough endoplasmic reticulum membrane	SEC61A1 SEC61A2	3.84e-04	29	21	2	GO:0030867
GeneOntologyCellularComponent	rough endoplasmic reticulum	SEC61A1 SEC61A2	1.87e-03	64	21	2	GO:0005791
GeneOntologyCellularComponent	transcription regulator complex	SOX2 SOX15 SOX14 PRDM10	2.66e-03	596	21	4	GO:0005667
Domain	SOXp	SOX1 SOX2 SOX14 SOX21	7.21e-12	5	22	4	PF12336
Domain	SOX_fam	SOX1 SOX2 SOX14 SOX21	7.21e-12	5	22	4	IPR022097
Domain	HMG_box	SOX1 SOX2 SOX15 SOX14 SOX21	3.85e-09	53	22	5	PF00505
Domain	HMG	SOX1 SOX2 SOX15 SOX14 SOX21	4.24e-09	54	22	5	SM00398
Domain	HMG_BOX_2	SOX1 SOX2 SOX15 SOX14 SOX21	4.24e-09	54	22	5	PS50118
Domain	-	SOX1 SOX2 SOX15 SOX14 SOX21	4.66e-09	55	22	5	1.10.30.10
Domain	HMG_box_dom	SOX1 SOX2 SOX15 SOX14 SOX21	1.10e-08	65	22	5	IPR009071
Domain	Plug_translocon	SEC61A1 SEC61A2	1.32e-06	2	22	2	PF10559
Domain	SecY	SEC61A1 SEC61A2	1.32e-06	2	22	2	PF00344
Domain	SecY_su_dom	SEC61A1 SEC61A2	1.32e-06	2	22	2	IPR023201
Domain	SecY_CS	SEC61A1 SEC61A2	1.32e-06	2	22	2	IPR030659
Domain	SECY_1	SEC61A1 SEC61A2	1.32e-06	2	22	2	PS00755
Domain	SECY_2	SEC61A1 SEC61A2	1.32e-06	2	22	2	PS00756
Domain	SecY/SEC61-alpha	SEC61A1 SEC61A2	1.32e-06	2	22	2	IPR002208
Domain	-	SEC61A1 SEC61A2	1.32e-06	2	22	2	1.10.3370.10
Domain	Translocon_Sec61/SecY_plug_dom	SEC61A1 SEC61A2	1.32e-06	2	22	2	IPR019561
Domain	-	PDIA5 PDCL	8.98e-03	122	22	2	3.40.30.10
Domain	Thioredoxin-like_fold	PDIA5 PDCL	1.04e-02	132	22	2	IPR012336
Pathway	REACTOME_FORMATION_OF_THE_POSTERIOR_NEURAL_PLATE	SOX1 SOX2	6.89e-05	10	18	2	M48036
Pathway	REACTOME_FORMATION_OF_THE_ANTERIOR_NEURAL_PLATE	SOX1 SOX2	8.41e-05	11	18	2	M48031
Pathway	KEGG_PROTEIN_EXPORT	SEC61A1 SEC61A2	4.18e-04	24	18	2	M6981
Pubmed	Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.	SOX1 SOX2 SOX15 SOX14 SOX21	1.02e-13	13	23	5	12194848
Pubmed	Deciphering the Sox-Oct partner code by quantitative cooperativity measurements.	SOX2 SOX15 SOX14 SOX21	1.03e-10	13	23	4	22344693
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX1 SOX2 SOX14 SOX21	3.44e-10	17	23	4	27241892
Pubmed	Expression of Sox genes in tooth development.	SOX1 SOX2 SOX14 SOX21	4.42e-10	18	23	4	26864488
Pubmed	Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR.	SOX15 SOX14 SOX21	1.01e-09	4	23	3	9827568
Pubmed	Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.	SOX1 SOX15 SOX14	2.12e-08	9	23	3	12100890
Pubmed	Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.	SOX1 SOX2 SOX14	5.54e-08	12	23	3	11071752
Pubmed	Seven new members of the Sox gene family expressed during mouse development.	SOX1 SOX2 SOX14	7.19e-08	13	23	3	8441686
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX1 SOX2 RFX2 BNC1 SOX15 SOX14 VENTX SOX21	7.25e-08	908	23	8	19274049
Pubmed	Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	SOX1 SOX2 SOX21	2.43e-07	19	23	3	30442713
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX1 SOX2 SOX15	3.33e-07	21	23	3	12815626
Pubmed	Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain.	SOX2 SOX14 SOX21	3.33e-07	21	23	3	29867344
Pubmed	The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.	SOX2 SOX15 SOX21	3.33e-07	21	23	3	16306355
Pubmed	Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.	SEC61A1 SEC61A2	4.18e-07	2	23	2	18480044
Pubmed	SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway.	SOX1 SOX2	4.18e-07	2	23	2	26040764
Pubmed	Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells.	SOX2 SOX21	4.18e-07	2	23	2	20824710
Pubmed	Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate.	SOX2 SOX21	4.18e-07	2	23	2	20687156
Pubmed	The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3.	SOX14 SOX21	4.18e-07	2	23	2	10441749
Pubmed	SOX2 and SOX21 in Lung Epithelial Differentiation and Repair.	SOX2 SOX21	4.18e-07	2	23	2	36361852
Pubmed	Sox21 inhibits glioma progression in vivo by forming complexes with Sox2 and stimulating aberrant differentiation.	SOX2 SOX21	4.18e-07	2	23	2	23463365
Pubmed	Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice.	SOX1 SOX2 SOX14	5.76e-07	25	23	3	19357274
Pubmed	Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15.	SOX1 SOX2 SOX21	1.01e-06	30	23	3	28560839
Pubmed	SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch.	SOX1 SOX2 SOX21	1.12e-06	31	23	3	19723505
Pubmed	Distinct SoxB1 networks are required for naïve and primed pluripotency.	SOX1 SOX2	1.25e-06	3	23	2	29256862
Pubmed	Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction.	SOX1 SOX2	1.25e-06	3	23	2	9609835
Pubmed	Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolution.	SOX2 SOX14	1.25e-06	3	23	2	12584449
Pubmed	Expression of Sox1, Sox2 and Sox9 is maintained in adult human cerebellar cortex.	SOX1 SOX2	1.25e-06	3	23	2	19061938
Pubmed	Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina.	SOX1 SOX2	1.25e-06	3	23	2	27031842
Pubmed	Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages.	SOX1 SOX2	2.51e-06	4	23	2	10446282
Pubmed	The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.	SEC61A1 SEC61A2	2.51e-06	4	23	2	10212142
Pubmed	Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.	SOX2 SOX15	2.51e-06	4	23	2	15863505
Pubmed	Distal Sox binding elements of the alphaB-crystallin gene show lens enhancer activity in transgenic mouse embryos.	SOX1 SOX2	2.51e-06	4	23	2	15113840
Pubmed	Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.	SEC61A1 SEC61A2	4.18e-06	5	23	2	9565615
Pubmed	Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells.	SOX2 SOX21	4.18e-06	5	23	2	22902753
Pubmed	Oct4 is required ~E7.5 for proliferation in the primitive streak.	SOX1 SOX2	4.18e-06	5	23	2	24244203
Pubmed	A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.	SOX1 SOX2	4.18e-06	5	23	2	2374589
Pubmed	Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells.	SOX2 SOX21	6.26e-06	6	23	2	36867267
Pubmed	Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress.	SEC61A1 SEC61A2	6.26e-06	6	23	2	16705175
Pubmed	Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.	SOX2 SOX14 SOX21	6.84e-06	56	23	3	33053343
Pubmed	Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells.	SOX1 SOX2	8.77e-06	7	23	2	15456859
Pubmed	Evidence that the SRY protein is encoded by a single exon on the human Y chromosome.	SOX1 SOX2	8.77e-06	7	23	2	8244390
Pubmed	Pairing SOX off: with partners in the regulation of embryonic development.	SOX1 SOX2	8.77e-06	7	23	2	10729834
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SOX1 SOX2 BRDT RFX2 SOX15 SOX21	1.11e-05	808	23	6	20412781
Pubmed	UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.	SOX1 SOX2	1.17e-05	8	23	2	36412518
Pubmed	Selective requirement for polycomb repressor complex 2 in the generation of specific hypothalamic neuronal subtypes.	SOX1 SOX2	1.17e-05	8	23	2	35245348
Pubmed	Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source.	SOX1 SOX2	1.17e-05	8	23	2	23776550
Pubmed	Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes.	SOX1 SOX2	1.17e-05	8	23	2	28515211
Pubmed	Prospective separation and transcriptome analyses of cortical projection neurons and interneurons based on lineage tracing by Tbr2 (Eomes)-GFP/Dcx-mRFP reporters.	SOX1 SOX2	1.17e-05	8	23	2	26248544
Pubmed	Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation.	SOX1 SOX2	1.50e-05	9	23	2	15652703
Pubmed	Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.	SOX1 SOX2	1.50e-05	9	23	2	23249739
Pubmed	Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program.	SOX1 SOX2	1.50e-05	9	23	2	29530878
Pubmed	Sox2 requirement in sonic hedgehog-associated medulloblastoma.	SOX1 SOX2	1.50e-05	9	23	2	23596255
Pubmed	Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons.	SOX1 SOX2	1.50e-05	9	23	2	25411508
Pubmed	Sox2 induces neuronal formation in the developing mammalian cochlea.	SOX1 SOX2	1.50e-05	9	23	2	20071536
Pubmed	Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.	SOX1 SOX2	1.50e-05	9	23	2	18522499
Pubmed	Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.	SOX2 SOX14 SOX21	1.79e-05	77	23	3	21525287
Pubmed	Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal.	SOX1 SOX2	1.88e-05	10	23	2	32150534
Pubmed	Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis.	SOX1 SOX2	1.88e-05	10	23	2	31249377
Pubmed	From head to toes: the multiple facets of Sox proteins.	SOX1 SOX2	1.88e-05	10	23	2	10037800
Pubmed	Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice.	SOX1 SOX2	1.88e-05	10	23	2	9512512
Pubmed	Coordination of progenitor specification and growth in mouse and chick spinal cord.	SOX1 SOX2	1.88e-05	10	23	2	25258086
Pubmed	Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development.	SOX1 SOX14	2.29e-05	11	23	2	31822965
Pubmed	WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum.	SOX1 SOX2	2.29e-05	11	23	2	22461560
Pubmed	SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways.	SOX2 SOX21	2.29e-05	11	23	2	34286693
Pubmed	The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX.	SOX1 SOX2	2.29e-05	11	23	2	36067402
Pubmed	An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin.	SOX2 SOX21	2.29e-05	11	23	2	26256211
Pubmed	Co-expression of Tbx6 and Sox2 identifies a novel transient neuromesoderm progenitor cell state.	SOX1 SOX2	2.29e-05	11	23	2	29084802
Pubmed	Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.	SOX1 SOX2	2.75e-05	12	23	2	15882093
Pubmed	Clonal and molecular analysis of the prospective anterior neural boundary in the mouse embryo.	SOX1 SOX2	2.75e-05	12	23	2	22186731
Pubmed	The role of assembly in insulin's biosynthesis.	SEC61A1 SEC61A2	2.75e-05	12	23	2	9631292
Pubmed	Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.	SOX1 SOX2	2.75e-05	12	23	2	27246266
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	HEATR5B SEC61A1 SEC61A2 AKAP8L PTPRA	3.14e-05	573	23	5	28330616
Pubmed	The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function.	SOX1 SOX2	3.25e-05	13	23	2	34256037
Pubmed	A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.	SOX1 SOX2	3.25e-05	13	23	2	8625802
Pubmed	Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.	SOX1 SOX2	3.25e-05	13	23	2	25805847
Pubmed	Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro.	SOX1 SOX2	3.79e-05	14	23	2	21766338
Pubmed	Pitx3 controls multiple aspects of lens development.	SOX1 SOX2	3.79e-05	14	23	2	19334279
Pubmed	Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.	SOX2 SOX15	3.79e-05	14	23	2	8921394
Pubmed	Pax6 is essential for lens fiber cell differentiation.	SOX1 SOX2	3.79e-05	14	23	2	19570848
Pubmed	Dentate gyrus development requires a cortical hem-derived astrocytic scaffold.	SOX1 SOX2	3.79e-05	14	23	2	33393905
Pubmed	A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.	SOX2 SOX14 SOX21	4.16e-05	102	23	3	19741146
Pubmed	Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.	SOX1 SOX2	4.37e-05	15	23	2	27930333
Pubmed	Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.	SOX1 SOX2	4.37e-05	15	23	2	15893981
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX2 SOX15	4.37e-05	15	23	2	30871468
Pubmed	Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification.	SOX1 SOX2	4.37e-05	15	23	2	23487311
Pubmed	Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells.	SOX1 SOX2	4.37e-05	15	23	2	21331042
Pubmed	Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes.	SOX1 SOX2	4.99e-05	16	23	2	30661984
Pubmed	Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.	SOX1 SOX2	4.99e-05	16	23	2	24257626
Pubmed	Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.	SOX1 SOX2	4.99e-05	16	23	2	17699610
Pubmed	GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis.	SOX1 SOX2	4.99e-05	16	23	2	30953627
Pubmed	Specification of neurotransmitter identity by Tal1 in thalamic nuclei.	SOX2 SOX14	4.99e-05	16	23	2	28685891
Pubmed	Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis.	SOX1 SOX2	4.99e-05	16	23	2	30504125
Pubmed	Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh.	SOX1 SOX2	5.66e-05	17	23	2	23444355
Pubmed	Regulation of mouse lens fiber cell development and differentiation by the Maf gene.	SOX1 SOX2	5.66e-05	17	23	2	10603348
Pubmed	Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice.	SOX1 SOX2	5.66e-05	17	23	2	28778798
Pubmed	Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model.	SOX1 SOX2	5.66e-05	17	23	2	35361248
Pubmed	Sox21 promotes hippocampal adult neurogenesis via the transcriptional repression of the Hes5 gene.	SOX2 SOX21	5.66e-05	17	23	2	22956844
Pubmed	TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.	SOX1 SOX2	5.66e-05	17	23	2	35950911
Pubmed	Oct4 regulates the embryonic axis and coordinates exit from pluripotency and germ layer specification in the mouse embryo.	SOX1 SOX2	5.66e-05	17	23	2	29915126
Pubmed	Sex-dependent expression of TRPV1 in bladder arterioles.	SOX2 SOX21	6.36e-05	18	23	2	27654891
Interaction	SOX14 interactions	SOX2 SOX14 VENTX	2.84e-07	12	23	3	int:SOX14
Interaction	GPS2 interactions	SOX2 RFX2 SOX15 AKAP8L	1.99e-05	144	23	4	int:GPS2
Interaction	SOX1 interactions	SOX1 SOX2	3.47e-05	8	23	2	int:SOX1
Interaction	POU5F1 interactions	SOX2 BRDT RFX2 SOX15 SOX14 SOX21	3.82e-05	584	23	6	int:POU5F1
Interaction	SOX21 interactions	SOX2 SOX21	8.17e-05	12	23	2	int:SOX21
Cytoband	Ensembl 112 genes in cytogenetic band chr3q21	SEC61A1 PDIA5	2.91e-03	160	23	2	chr3q21
GeneFamily	SRY-boxes	SOX1 SOX2 SOX15 SOX14 SOX21	2.16e-12	19	15	5	757
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_500	SOX2 BRDT BNC1 SEC61A1 DDX43 PDCL	1.91e-06	382	22	6	gudmap_developingGonad_e14.5_ ovary_500
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_200	MNS1 SOX2 BRDT DDX43	1.17e-05	139	22	4	gudmap_dev gonad_e13.5_M_GermCell_Oct_200
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#4_top-relative-expression-ranked_500	BRDT SEC61A1 DDX43	2.87e-05	58	22	3	gudmap_developingGonad_e14.5_ ovary_500_k4
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000	SOX2 BRDT BNC1 SEC61A1 DDX43 PDCL	1.06e-04	776	22	6	gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000	BRDT BNC1 SEC61A1 SEC61A2 DDX43 PDCL	1.21e-04	795	22	6	gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_k-means-cluster#1_top-relative-expression-ranked_100	BRDT DDX43	1.93e-04	20	22	2	gudmap_developingGonad_e16.5_testes_100_k1
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#2_top-relative-expression-ranked_1000	BRDT SEC61A1 DDX43	2.89e-04	126	22	3	gudmap_developingGonad_e14.5_ ovary_1000_k2
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_200	SOX2 BRDT DDX43	4.19e-04	143	22	3	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_200
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_k-means-cluster#4_top-relative-expression-ranked_200	BRDT DDX43	4.99e-04	32	22	2	gudmap_developingGonad_e16.5_testes_200_k4
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_top-relative-expression-ranked_200	SOX2 BRDT SEC61A1	5.71e-04	159	22	3	gudmap_developingGonad_e14.5_ testes_200
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_500	MNS1 SOX2 BRDT DDX43	6.13e-04	387	22	4	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_500
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_top-relative-expression-ranked_200	BRDT SEC61A1 DDX43	6.14e-04	163	22	3	gudmap_developingGonad_e16.5_testes_200
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_500	MNS1 SOX2 BRDT DDX43	6.68e-04	396	22	4	gudmap_dev gonad_e13.5_M_GermCell_Oct_500
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_500	SOX2 BNC1 SEC61A1 PDCL	7.54e-04	409	22	4	gudmap_developingGonad_e12.5_ovary_500
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_500	SOX2 BNC1 SEC61A1 PDCL	8.10e-04	417	22	4	gudmap_developingGonad_e11.5_ovary + mesonephros_500
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#1_top-relative-expression-ranked_1000	BRDT SEC61A1 DDX43	8.46e-04	182	22	3	gudmap_developingGonad_e16.5_ovary_1000_k1
CoexpressionAtlas	ECTO amniotic fluid MSC_vs_ECTO blastocyst-Confounder_removed-fold2.0_adjp0.05	SOX1 SOX2 SOX21	8.59e-04	183	22	3	PCBC_ratio_ECTO amniotic fluid MSC_vs_ECTO blastocyst_cfr-2X-p05
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 NRG2 SOX15 SOX21	2.21e-06	183	23	4	ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCell	facs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 NRG2 SOX15 SOX21	2.21e-06	183	23	4	f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCell	Cerebellum-Macroglia\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX1 SOX2 PTPRA SOX21	2.26e-06	184	23	4	91b047a01d2cad231308279ca37fa699630f7864
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 BNC1 SOX15 SOX21	2.51e-06	189	23	4	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 BNC1 SOX15 SOX21	2.51e-06	189	23	4	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOX1 SOX2 PTPRA SOX21	2.78e-06	194	23	4	68d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX1 SOX2 SOX21	6.25e-05	151	23	3	60aced0c1cc6b509b73308d03d58a3c44d712ef4
ToppCell	Cerebellum-Macroglia-ASTROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX1 SOX2 SOX21	6.25e-05	151	23	3	71841d2001200d1595c85c2b007ee20791a72927
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX2 SOX15 SOX21	8.42e-05	167	23	3	29d271643f3a1718b53db77b7d093ec94225a824
ToppCell	Ciliated_cells-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	MNS1 APOBEC4 SOX21	8.88e-05	170	23	3	3d3a03979014df3a05c49be18010c6b94d786707
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX1 SOX2 BNC1	8.88e-05	170	23	3	67619685a145fbd4a86d67f2c1c2ba3d5fe52fbe
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	MNS1 SOX2 APOBEC4	9.19e-05	172	23	3	187ae91148d293537afc77e10da2b64302322224
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX2 SOX15 SOX21	9.35e-05	173	23	3	1b2508cc890430bd4b2cf232c633928edb86c57e
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SOX2 SOX15 PRDM10	9.51e-05	174	23	3	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	facs-Trachea-nan-18m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 SOX15 SOX21	9.67e-05	175	23	3	eb87275da6f61ecb4fbc89421dfd27bead1e0f48
ToppCell	facs-Trachea-nan-18m-Epithelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 SOX15 SOX21	9.67e-05	175	23	3	3883675a726dd0c6c3a7113d59be2a093ea2dc6f
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX2 SOX15 SOX21	1.02e-04	178	23	3	fb8f8d95f6b08378fb42c4076ee040276faa296f
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX2 SOX15 SOX21	1.02e-04	178	23	3	b89c4d015b44bf538aa39969ef8778877c8023f1
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX2 SOX15 SOX21	1.07e-04	181	23	3	f50561fdacfb83ba85fe6476e7cbc2bad1ebc826
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX2 SOX15 SOX21	1.07e-04	181	23	3	6b43dcaeeb02ad5900772b6f16f1581847050e38
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SOX1 SOX2 SOX21	1.09e-04	182	23	3	dc29e8735c3562ce32322351d28f7d9709208ebf
ToppCell	Ciliated_cells-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	MNS1 SOX2 APOBEC4	1.09e-04	182	23	3	e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX2 SOX15 SOX21	1.12e-04	184	23	3	45ff845ceed5960a997545c1009012b65e377d50
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX1 NRG2 SOX21	1.12e-04	184	23	3	6b0c110d8930df99043c3b99cf4d873985126960
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX1 NRG2 SOX21	1.12e-04	184	23	3	35928fc5f7bbf8c7b09181a2bd27e22dff42ec16
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-respiratory_basal_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX2 SOX15 SOX21	1.12e-04	184	23	3	2cc2646dee3c6001f7c10b7449c17d1935021958
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX1 SOX2 SOX21	1.12e-04	184	23	3	7712f2e1fae5cdde2d4e355b860dc8536b28e4f6
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SOX2 BNC1 SOX15	1.14e-04	185	23	3	e0172e0ab0f1d7151a3c3c63bb7c84d6bda92035
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SOX1 SOX2 SOX21	1.16e-04	186	23	3	c7983281a290201567b398e9ea6baddb96c692bb
ToppCell	facs-Trachea-nan-18m-Epithelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 SOX15 SOX21	1.18e-04	187	23	3	8882a638af7165b2910ba8e932d55475d7bfb003
ToppCell	Ciliated_cells-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	MNS1 SOX2 APOBEC4	1.18e-04	187	23	3	6fa38dbccca36bc7a4fef46de74c6688f599f421
ToppCell	multiciliated\|World / shred by cell class for bronchial biopsy	MNS1 RFX2 APOBEC4	1.20e-04	188	23	3	6833c1f0f265ef5448fa65033550ed7efc2f8d7b
ToppCell	tumor_Lung-Epithelial_cells-tS3\|tumor_Lung / Location, Cell class and cell subclass	MNS1 SOX2 APOBEC4	1.20e-04	188	23	3	26326b4e298e33f9ba393fc632238aa8c54b1ea3
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	MNS1 SOX2 APOBEC4	1.21e-04	189	23	3	dc440015949a768188c67661b6be63b1ead1a0f0
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	SOX2 BNC1 SOX15	1.21e-04	189	23	3	aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX2 SOX15 SOX21	1.23e-04	190	23	3	47e07ea22733306d8885ee9e5f0b033e2f5e2afb
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MNS1 RFX2 APOBEC4	1.23e-04	190	23	3	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX2 SOX15 SOX21	1.23e-04	190	23	3	261b8afddfdcba4f70b50df126cef7ad00a0aae0
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	MNS1 RFX2 APOBEC4	1.23e-04	190	23	3	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)\|356C / Donor, Lineage, Cell class and subclass (all cells)	MNS1 SOX2 APOBEC4	1.25e-04	191	23	3	e314dd8f1a841cab847ae3703bedfe1bc623ac61
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX2 SOX15 SOX21	1.25e-04	191	23	3	116fba9badea093e11f370996247cca0e4c02e8f
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MNS1 SOX2 APOBEC4	1.25e-04	191	23	3	8a5a2188b13ef4bbfd626a42565566708a751c1b
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-immature_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MNS1 BRDT PTPRA	1.27e-04	192	23	3	cd9bccbef1ef6bb39c310039884e2acb81e63c7c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SOX2 RFX2 APOBEC4	1.27e-04	192	23	3	31c6046589e2fbb0486fd044c5b128099d37872f
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SOX2 RFX2 APOBEC4	1.27e-04	192	23	3	03acd4a26b986e34eee608747347791122f1aa52
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-basal_intermediate_\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SOX2 SOX15 SOX21	1.29e-04	193	23	3	83d2dd823808a2b5ca1a6889eefb541ec042b24c
ToppCell	distal-Epithelial-Proximal_Ciliated-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MNS1 SOX2 APOBEC4	1.33e-04	195	23	3	0e3f74e0877d33c11f048b9be8394596cf5c9c4c
ToppCell	distal-Epithelial-Proximal_Ciliated\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MNS1 SOX2 APOBEC4	1.33e-04	195	23	3	abe7998421dc59bdae35c0c2251c4a1ebef5e021
ToppCell	distal-3-Epithelial-Proximal_Ciliated\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MNS1 SOX2 APOBEC4	1.37e-04	197	23	3	15b4d1203943ce90a7083178d4a4284d9b323071
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MNS1 RFX2 APOBEC4	1.39e-04	198	23	3	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SOX2 NRG2 SOX15	1.39e-04	198	23	3	7063d74d79f53d5c59c853a2575f9d3ef12f19ea
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SOX2 SOX15 SOX21	1.39e-04	198	23	3	6e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRG2 BNC1 SOX15	1.39e-04	198	23	3	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	medial-Epithelial-Ciliated\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MNS1 SOX2 APOBEC4	1.41e-04	199	23	3	a2daa42b100c422dc8c04fb7d2ebf54293eef574
ToppCell	medial-Epithelial-Ciliated-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MNS1 SOX2 APOBEC4	1.41e-04	199	23	3	526002f16bbf61cf086278d45a401cc0b0b757a8
ToppCell	medial-2-Epithelial-Ciliated\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MNS1 SOX2 APOBEC4	1.41e-04	199	23	3	c02f04a5aa79ee0cf427f6e94b93ceab38ebbcd7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	SOX1 SOX2 SOX21	1.44e-04	200	23	3	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	Biopsy_Control_(H.)-Epithelial-Differentiating_Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	MNS1 SOX2 APOBEC4	1.44e-04	200	23	3	a552a99f5e4fa00dfb7775e5a3e1f62f1530d104
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	SOX1 SOX2 SOX21	1.44e-04	200	23	3	474e6ab48f199315f3cca86b81fdf54e0461b7b8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	SOX1 SOX2 SOX21	1.44e-04	200	23	3	ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells-Stem_cells\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	SOX1 SOX2 SOX21	1.44e-04	200	23	3	01a29651e9bb64ef7666c6a61ec396eeb88b2816
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Cabp7_(Retrosplenial_areas,_subiculum,_presubiculum,_Cabp7+)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SOX14 VENTX	3.92e-04	57	23	2	6bf3886d5ebe6bf65a503648ac455415cbb4fc6c
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Cabp7_(Retrosplenial_areas,_subiculum,_presubiculum,_Cabp7+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SOX14 VENTX	3.92e-04	57	23	2	69d867b775be8e68d274c149e406cc306cee7f63
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Otx2-Inhibitory_Neuron.Gad1Gad2.Otx2-Chrna3_(SN/VTA_(dorsal_SNr))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SOX15 SOX14	6.78e-04	75	23	2	730a08f846a155d2c892259f2c610081d40fc2c8
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Otx2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SOX15 SOX14	6.78e-04	75	23	2	f0185de0ce497997df1027a51c099d91294bba07
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Otx2-Inhibitory_Neuron.Gad1Gad2.Otx2-Chrna3_(SN/VTA_(dorsal_SNr))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SOX15 SOX14	6.78e-04	75	23	2	59fe56388697037b335f334cb3461f15c7b3b506
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Dpy19l1_(Neuron.Gad1Gad2.Cplx3-Dpy19l1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SOX14 VENTX	7.15e-04	77	23	2	4a0a2f1a021790ff598a8655811eac1c367316b3
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Dpy19l1_(Neuron.Gad1Gad2.Cplx3-Dpy19l1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SOX14 VENTX	7.15e-04	77	23	2	459fe29a53b88af77a4ced7b11fa1d0a17fec8e5
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX15 DDX43	1.40e-03	108	23	2	63d45cc3ee149a7baf255b70409f8ea54c56157b
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3-Tnr\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX15 DDX43	1.40e-03	108	23	2	d57eeda825b6e0e64bae185896ae7eea6a2a50e9
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX15 DDX43	1.40e-03	108	23	2	db8472616886c6195f8c27c00f00133a9c10691d
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX15 DDX43	1.40e-03	108	23	2	c2aa6bf8554bfb6b0f9c5f6658601c6cf7c8bdbc
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Mixed_Serous_and_Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	SOX1 SOX21	1.58e-03	115	23	2	c724e8b1fddcefdaa8d247aaff68c986538068f7
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Papillary_Adenocarcinoma-8\|TCGA-Lung / Sample_Type by Project: Shred V9	BRDT SOX14	1.75e-03	121	23	2	949082d2f301511bd31a5c29621049e4a3f65703
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Ptrf\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	APOBEC4 DDX43	2.11e-03	133	23	2	a1bc34e5dda4ff4716b857931cc196f6770f58f4
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Proliferative_Immature_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SOX1 APBA2	2.17e-03	135	23	2	ed0f94d3839eea3b60217c4352159ed481361f13
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-MEP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	APBA2 DDX43	2.23e-03	137	23	2	0bb5cccc31e7c44d44a2db3f59b68f9a81503151
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DDX43 SOX21	2.30e-03	139	23	2	a957ea4e581646c76b16b6a7f89579b8c7ac35b6
ToppCell	PCW_05-06-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SOX2 SOX21	2.33e-03	140	23	2	8abbd5dc799943b49cd0045d0da405c3f3d0db6b
ToppCell	PCW_05-06-Epithelial-Epithelial_ciliated\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SOX2 SOX21	2.33e-03	140	23	2	e4689232c473d239b07a7fbcaaa3414fbd9badea
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SOX1 SOX15	2.46e-03	144	23	2	04f9054895be2275eecda687a6eeb02fa5ec69b9
ToppCell	Ciliated_cells-A-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	SOX2 APOBEC4	2.53e-03	146	23	2	20f080318e9cbfd9b8b90a5e9f704d6d85b969ee
ToppCell	Influenza_Severe-CD4+_T_naive\|World / Disease group and Cell class	APBA2 BRDT	2.63e-03	149	23	2	ce6552063510aa3e0b9d6e5b531eea67410e7056
ToppCell	Ciliated_cells-A-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	MNS1 SOX2	2.70e-03	151	23	2	9d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_PENK\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX1 DDX43	2.74e-03	152	23	2	88a810d41edb5a917c23cb5ba5a387227e1312cb
ToppCell	10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEMP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	BRDT NRG2	2.77e-03	153	23	2	14753baa9980f75206fefc3c8b43685fd4178a43
ToppCell	mild_COVID-19_(asymptomatic)-MAIT\|World / disease group, cell group and cell class (v2)	BRDT NRG2	2.77e-03	153	23	2	2b4c69f6db17927d6506a645ac058133e60b0103
ToppCell	mild_COVID-19_(asymptomatic)-MAIT\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	BRDT NRG2	2.77e-03	153	23	2	26852f3d8f80e102e24bcb90e24aac26fdc9a32c
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	HEATR5B PDIA5	2.81e-03	154	23	2	1c62290a2558fd6401b27de5a867d243b143b00a
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT1_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SOX2 SOX21	2.81e-03	154	23	2	8a643d91896af9b630a715fb284c1523d01ad1a3
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SOX1 SOX2	2.85e-03	155	23	2	105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MNS1 SOX15	2.88e-03	156	23	2	e0aef6104be16b12304b8e30358f444c1660e92f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MNS1 SOX15	2.88e-03	156	23	2	5b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	SEC61A2 PRDM10	2.88e-03	156	23	2	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	10x5'-Lung-Myeloid_Monocytic-Cycling_mono\|Lung / Manually curated celltypes from each tissue	C7orf33 PRDM10	2.88e-03	156	23	2	63b8cf14361b282872bc1c5b65d9fbc83e81a089
ToppCell	Influenza_Severe-CD4+_T_naive\|Influenza_Severe / Disease group and Cell class	APBA2 BRDT	2.92e-03	157	23	2	287bdc4e455cd0160261a93d13538e0def49fcd4
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX1 SOX2	2.99e-03	159	23	2	0dccc4275b9b4f8554dd556da7218e130bff8fd1
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX2 APOBEC4	3.03e-03	160	23	2	1f4ee446436726c3d373f56d87dd80b6a12e8b9e
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	APBA2 NRG2	3.03e-03	160	23	2	8aaf6ac4f33ea291387fdbf9ff1a91d559391774
ToppCell	severe_influenza-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	APBA2 PDIA5	3.03e-03	160	23	2	a1181ef36b453eba53b04d836aa9f65a71354cdb
Disease	intestinal cancer (implicated_via_orthology)	SOX15 SOX14	2.84e-04	32	23	2	DOID:10155 (implicated_via_orthology)
Disease	Squamous cell carcinoma of esophagus	SOX2 VENTX	2.48e-03	95	23	2	C0279626
Disease	dyslexia	HEATR5B PTPRA	7.03e-03	162	23	2	EFO_0005424
Disease	hair colour measurement	APBA2 NRG2 BNC1	1.17e-02	615	23	3	EFO_0007822

Protein segments in the cluster

Peptide	Gene	Start	Entry
NSNENPRKMCEQMRL	BRDT	466	Q58F21
NKPRNIVRHLNMPQM	APOBEC4	311	Q8WW27
PRLHMPMNRNNRDKD	BNC1	411	Q01954
RNPSKNIRMMQAQEA	APBA2	386	Q99767
RHKKPNPHQNMNRGM	C7orf33	66	Q8WU49
DHNRNRRLMMEQSKK	AKAP8L	506	Q9ULX6
KKQRKQMHNHLRQNM	NRG2	431	O14511
MQRMHNPEREAKKAD	PRDM10	691	Q9NQV6
MPKQATVMRQNVKRA	HEATR5B	251	Q9P2D3
AHQQKREMERKMERP	DDX43	626	Q9NXZ2
KRMMPHFQKAATQLR	PDIA5	186	Q14554
QNDKMRTGNLPANMK	PTPRA	546	P18433
RKQRMEEMRQQLHKG	PDCL	141	Q13371
LMNAQKQRMKQLEHR	MNS1	391	Q8NEH6
RRKMAQENPKMHNSE	SOX2	56	P48431
AQRRKMAQENPKMHN	SOX21	21	Q9Y651
AKQLKEQQMVMRGHR	SEC61A2	391	Q9H9S3
QYMAMRQQPMHQKPR	RFX2	286	P48378
RRKMAQENPKMHNSE	SOX1	66	O00570
VNMNRDIKMPLRKHN	C12orf40	76	Q86WS4
SAQRRQMAQQNPKMH	SOX15	61	O60248
AKQLKEQQMVMRGHR	SEC61A1	391	P61619
GQRRKMAQENPKMHN	SOX14	21	O95416
NRRMKHKRQMQDPQL	VENTX	141	O95231