Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondynein light intermediate chain binding

RILP RAB11FIP3

2.25e-0428162GO:0051959
GeneOntologyMolecularFunctionsmall GTPase binding

NPC1L1 RILP RAB11FIP3

1.97e-03321163GO:0031267
GeneOntologyMolecularFunctionmyosin binding

SPTBN5 NPC1L1

2.07e-0385162GO:0017022
GeneOntologyMolecularFunctionGTPase binding

NPC1L1 RILP RAB11FIP3

2.73e-03360163GO:0051020
GeneOntologyMolecularFunctionGTPase regulator activity

MYO9A ARHGEF1 HERC1

7.12e-03507163GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

MYO9A ARHGEF1 HERC1

7.12e-03507163GO:0060589
GeneOntologyMolecularFunctionactin filament binding

SPTBN5 MYO9A

1.39e-02227162GO:0051015
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

ARHGEF1 HERC1

1.44e-02231162GO:0005085
GeneOntologyBiologicalProcessnegative regulation of G2/M transition of mitotic cell cycle

MIIP INTS3 RINT1

2.50e-0575163GO:0010972
GeneOntologyBiologicalProcessnegative regulation of cell cycle G2/M phase transition

MIIP INTS3 RINT1

2.71e-0577163GO:1902750
GeneOntologyBiologicalProcessregulation of G2/M transition of mitotic cell cycle

MIIP INTS3 RINT1

9.20e-05116163GO:0010389
GeneOntologyBiologicalProcessregulation of cell cycle G2/M phase transition

MIIP INTS3 RINT1

1.32e-04131163GO:1902749
GeneOntologyBiologicalProcessG2/M transition of mitotic cell cycle

MIIP INTS3 RINT1

2.05e-04152163GO:0000086
GeneOntologyBiologicalProcesscell cycle G2/M phase transition

MIIP INTS3 RINT1

2.90e-04171163GO:0044839
GeneOntologyBiologicalProcessregulation of cell cycle process

MIIP INTS3 CUL9 RINT1 RAB11FIP3

3.42e-04845165GO:0010564
GeneOntologyBiologicalProcessmitotic cell cycle process

MIIP INTS3 CUL9 RINT1 RAB11FIP3

3.59e-04854165GO:1903047
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle phase transition

MIIP INTS3 RINT1

5.97e-04219163GO:1901991
GeneOntologyBiologicalProcessmitotic cell cycle

MIIP INTS3 CUL9 RINT1 RAB11FIP3

7.88e-041014165GO:0000278
GeneOntologyBiologicalProcessvesicle-mediated transport between endosomal compartments

RILP RAB11FIP3

8.48e-0456162GO:0098927
GeneOntologyBiologicalProcessregulation of mitotic cell cycle

MIIP INTS3 CUL9 RINT1

9.40e-04594164GO:0007346
GeneOntologyBiologicalProcessmitotic G2/M transition checkpoint

INTS3 RINT1

9.41e-0459162GO:0044818
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle

MIIP INTS3 RINT1

1.24e-03282163GO:0045930
GeneOntologyBiologicalProcessnegative regulation of cell cycle phase transition

MIIP INTS3 RINT1

1.64e-03311163GO:1901988
MousePhenoincreased Ly6C low monocyte number

ARHGEF1 HERC1

2.60e-058142MP:0013025
MousePhenoabnormal Ly6C low monocyte number

ARHGEF1 HERC1

8.42e-0514142MP:0013024
MousePhenoincreased pituitary gland tumor incidence

CUL9 RINT1

9.71e-0515142MP:0010320
DomainSpectrin_repeat

SPTBN5 PPL

2.41e-0429152IPR002017
DomainSpectrin/alpha-actinin

SPTBN5 PPL

2.94e-0432152IPR018159
DomainSPEC

SPTBN5 PPL

2.94e-0432152SM00150
DomainPH

SPTBN5 ARHGEF1

2.04e-02278152SM00233
DomainPH_DOMAIN

SPTBN5 ARHGEF1

2.05e-02279152PS50003
DomainPH_domain

SPTBN5 ARHGEF1

2.07e-02280152IPR001849
Pubmed

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.

RILP RAB11FIP3

2.97e-06616225272277
Pubmed

Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.

RTRAF RAB11FIP3

6.92e-052716218685082
Pubmed

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.

RTRAF HERC1

4.06e-046516228276505
Pubmed

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.

MYO9A PPL

4.06e-046516223319000
Pubmed

Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.

CUL9 NPC1L1

4.18e-046616215790807
InteractionEEF1AKMT3 interactions

INTS3 CUL9 RINT1 ARHGEF1 HERC1

6.93e-06364165int:EEF1AKMT3
InteractionCCDC65 interactions

CCDC65 HERC1

5.35e-0514162int:CCDC65
InteractionUBXN6 interactions

INTS3 MYO9A ARHGEF1 HERC1

1.04e-04325164int:UBXN6
Cytoband16p13.3

PPL RAB11FIP3

3.21e-0324416216p13.3
CytobandEnsembl 112 genes in cytogenetic band chr16p13

PPL RAB11FIP3

9.46e-03426162chr16p13
CytobandEnsembl 112 genes in cytogenetic band chr6p21

IP6K3 CUL9

1.30e-02503162chr6p21
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYO9A ARHGEF1 PPL

4.57e-05199163d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCellBronchial-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CUL9 RINT1 NDST2

4.57e-051991636e7f7214317f2af2ba8523df9896f54b7294d58a
ToppCellBronchial-10x5prime-Immune_Myeloid-Myeloid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CUL9 RINT1 NDST2

4.57e-051991635f499595597c10857bba8272f62afe4d32d733ac
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYO9A ARHGEF1 PPL

4.64e-052001638683445ad5b70748c4a1f12eb77d47623085147e
Diseaseresting heart rate, chronic obstructive pulmonary disease

IP6K3 HERC1

1.04e-0430152EFO_0000341, EFO_0004351
DiseaseHVA measurement, MHPG measurement

MYO9A PPL

1.86e-0440152EFO_0005131, EFO_0005133

Protein segments in the cluster

PeptideGeneStartEntry
VHVLLLDDLLLLLQR

ARHGEF1

666

Q92888
LDDLLLLLQRQDERL

ARHGEF1

671

Q92888
QLLALQRHRLSLLEE

CCDC65

126

Q8IXS2
EQLQRLLLVNAELRH

RILP

146

Q96NA2
LIEDLRKQLEHLQLL

RAB11FIP3

621

O75154
LEQILEHLDNLRLNL

INTS3

921

Q68E01
QLRAELRLEALHQIL

HERC1

1631

Q15751
LLRLQLEEEQHRRQL

PPL

1461

O60437
RELLEPILHQLRALL

IP6K3

296

Q96PC2
LDLDLLLELLELQER

NPC1L1

436

Q9UHC9
LLELLELQERLRHLQ

NPC1L1

441

Q9UHC9
LLRRIQERLLAILQH

CUL9

2411

Q8IWT3
AQILRLLHIEELREL

RTRAF

201

Q9Y224
ELAQLRLLNLELLRQ

MIIP

6

Q5JXC2
ILEETQKHLRRLELL

SPTBN5

1491

Q9NRC6
LLLTLRDHLLQLEQQ

RINT1

651

Q6NUQ1
ARQLELHRLILLLIA

NDST2

11

P52849
LQDLLHQEVLRRIIL

MYO9A

1011

B2RTY4