Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

9.38e-107474GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

9.38e-107474GO:0018685
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.60e-0910474GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.60e-0910474GO:0120250
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.60e-0910474GO:0102033
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.90e-0813474GO:0016713
GeneOntologyMolecularFunctionarachidonate binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

3.61e-0815474GO:0050544
GeneOntologyMolecularFunctionicosanoid binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

4.80e-0816474GO:0050542
GeneOntologyMolecularFunctionicosatetraenoic acid binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

4.80e-0816474GO:0050543
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.77e-0724474GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

4.54e-0727474GO:0008391
GeneOntologyMolecularFunctionlong-chain fatty acid binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.29e-0728474GO:0036041
GeneOntologyMolecularFunctionaromatase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.34e-0635474GO:0070330
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.28e-0649474GO:0016712
GeneOntologyMolecularFunctionmedium-chain fatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

5.42e-062472GO:0140981
GeneOntologyMolecularFunction16-hydroxypalmitate dehydrogenase activity

CYP4A11 CYP4A22

5.42e-062472GO:0103002
GeneOntologyMolecularFunctionfatty acid binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.08e-0569474GO:0005504
GeneOntologyMolecularFunctionalpha-tocopherol omega-hydroxylase activity

CYP4F12 CYP4F11

5.40e-055472GO:0052871
GeneOntologyMolecularFunctiontransition metal ion binding

CYP4F12 TUT4 PAPOLA L3MBTL3 CYP4F11 SUV39H2 CYP4A11 POLA1 SHANK3 PCK1 CYP4A22

7.62e-0511894711GO:0046914
GeneOntologyMolecularFunctionmonocarboxylic acid binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.16e-04107474GO:0033293
GeneOntologyMolecularFunctionmonooxygenase activity

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.54e-04115474GO:0004497
GeneOntologyMolecularFunctioncarboxylic acid binding

CYP4F12 CYP4F11 CYP4A11 PCK1 CYP4A22

2.40e-04239475GO:0031406
GeneOntologyMolecularFunctionorganic acid binding

CYP4F12 CYP4F11 CYP4A11 PCK1 CYP4A22

3.18e-04254475GO:0043177
GeneOntologyMolecularFunctionheme binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

4.69e-04154474GO:0020037
GeneOntologyMolecularFunctionDNA nuclease activity

TREX1 APLF DNASE2

5.27e-0467473GO:0004536
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.94e-04164474GO:0046906
GeneOntologyMolecularFunctioniron ion binding

CYP4F12 CYP4F11 CYP4A11 CYP4A22

6.22e-04166474GO:0005506
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.11e-03194474GO:0016705
GeneOntologyMolecularFunctionmagnesium ion binding

CILK1 TREX1 PAPOLA PCK1

2.69e-03247474GO:0000287
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

TREX1 APLF POLA1 DNASE2

3.32e-03262474GO:0140097
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

CYP4F12 CYP4F11

4.00e-0340472GO:0016709
GeneOntologyMolecularFunctionDNA endonuclease activity

APLF DNASE2

4.82e-0344472GO:0004520
GeneOntologyMolecularFunctionnucleotidyltransferase activity

TUT4 PAPOLA POLA1

5.49e-03152473GO:0016779
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CILK1 TUT4 LTK PAPOLA PIK3C2A POLA1 PCK1

6.01e-03938477GO:0016772
GeneOntologyBiologicalProcessomega-hydroxylase P450 pathway

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.33e-0814474GO:0097267
GeneOntologyBiologicalProcessleukotriene B4 catabolic process

CYP4F12 CYP4F11 CYP4A11

2.21e-076473GO:0036101
GeneOntologyBiologicalProcessleukotriene B4 metabolic process

CYP4F12 CYP4F11 CYP4A11

3.86e-077473GO:0036102
GeneOntologyBiologicalProcessleukotriene catabolic process

CYP4F12 CYP4F11 CYP4A11

6.16e-078473GO:0036100
GeneOntologyBiologicalProcessicosanoid catabolic process

CYP4F12 CYP4F11 CYP4A11

1.81e-0611473GO:1901523
GeneOntologyBiologicalProcesslong-chain fatty acid catabolic process

CYP4F12 CYP4F11 CYP4A11

2.40e-0612473GO:0042758
GeneOntologyBiologicalProcessoxylipin metabolic process

CYP4F11 CYP4A11

5.08e-062472GO:0031407
GeneOntologyBiologicalProcessoxylipin biosynthetic process

CYP4F11 CYP4A11

5.08e-062472GO:0031408
GeneOntologyBiologicalProcesslauric acid metabolic process

CYP4A11 CYP4A22

1.52e-053472GO:0048252
GeneOntologyBiologicalProcessDNA synthesis involved in UV-damage excision repair

TREX1 POLA1

1.52e-053472GO:1904161
GeneOntologyBiologicalProcessmenaquinone catabolic process

CYP4F12 CYP4F11

1.52e-053472GO:0042361
GeneOntologyBiologicalProcessfatty acid derivative catabolic process

CYP4F12 CYP4F11 CYP4A11

1.66e-0522473GO:1901569
GeneOntologyBiologicalProcessarachidonate metabolic process

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.73e-0568474GO:0019369
GeneOntologyBiologicalProcessmenaquinone metabolic process

CYP4F12 CYP4F11

3.04e-054472GO:0009233
GeneOntologyBiologicalProcessphylloquinone metabolic process

CYP4F12 CYP4F11

3.04e-054472GO:0042374
GeneOntologyBiologicalProcessphylloquinone catabolic process

CYP4F12 CYP4F11

3.04e-054472GO:0042376
GeneOntologyBiologicalProcessvitamin K catabolic process

CYP4F12 CYP4F11

3.04e-054472GO:0042377
GeneOntologyBiologicalProcessprostaglandin catabolic process

CYP4F12 CYP4F11

7.58e-056472GO:1905344
GeneOntologyBiologicalProcessprostanoid catabolic process

CYP4F12 CYP4F11

7.58e-056472GO:0062232
GeneOntologyBiologicalProcessvitamin E metabolic process

CYP4F12 NPC1L1

7.58e-056472GO:0042360
GeneOntologyBiologicalProcessleukotriene metabolic process

CYP4F12 CYP4F11 CYP4A11

1.11e-0441473GO:0006691
GeneOntologyBiologicalProcessfatty acid catabolic process

CYP4F12 CYP4F11 CYP4A11 PCK1

1.41e-04116474GO:0009062
GeneOntologyBiologicalProcesslong-chain fatty acid metabolic process

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.82e-04124474GO:0001676
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.05e-04128474GO:0033559
GeneOntologyBiologicalProcessfat-soluble vitamin metabolic process

CYP4F12 CYP4F11 NPC1L1

2.14e-0451473GO:0006775
GeneOntologyBiologicalProcessvitamin K metabolic process

CYP4F12 CYP4F11

2.76e-0411472GO:0042373
GeneOntologyBiologicalProcessicosanoid metabolic process

CYP4F12 CYP4F11 CYP4A11 CYP4A22

3.05e-04142474GO:0006690
GeneOntologyBiologicalProcessmonocarboxylic acid catabolic process

CYP4F12 CYP4F11 CYP4A11 PCK1

3.30e-04145474GO:0072329
GeneOntologyBiologicalProcessfat-soluble vitamin catabolic process

CYP4F12 CYP4F11

3.31e-0412472GO:0042363
GeneOntologyBiologicalProcessUV-damage excision repair

TREX1 POLA1

4.54e-0414472GO:0070914
GeneOntologyBiologicalProcessmedium-chain fatty acid metabolic process

CYP4A11 CYP4A22

5.24e-0415472GO:0051791
GeneOntologyBiologicalProcessfatty acid metabolic process

TREX1 CYP4F12 CYP4F11 CYP4A11 PCK1 CYP4A22

5.96e-04461476GO:0006631
GeneOntologyBiologicalProcessorganic hydroxy compound catabolic process

CYP4F12 CYP4F11 CYP4A11

6.17e-0473473GO:1901616
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP4F12 CYP4F11 CYP4A11 CYP4A22

7.47e-04180474GO:0120254
GeneOntologyBiologicalProcessvitamin catabolic process

CYP4F12 CYP4F11

7.60e-0418472GO:0009111
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

CYP4F12 CYP4F11 CYP4A11

8.66e-0482473GO:1901568
GeneOntologyBiologicalProcessketone catabolic process

CYP4F12 CYP4F11

1.04e-0321472GO:0042182
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP4F12 CYP4A11

1.14e-0322472GO:0019373
GeneOntologyBiologicalProcesslinoleic acid metabolic process

CYP4A11 CYP4A22

1.25e-0323472GO:0043651
GeneOntologyBiologicalProcessregulation of immunoglobulin production

TREX1 TLR9 APLF

1.33e-0395473GO:0002637
GeneOntologyCellularComponentendoplasmic reticulum membrane

TREX1 MBTPS1 CYP4F12 TLR9 PTCHD3 BCAP29 CYP4F11 CYP4A11 RNF43 CYP4A22

5.97e-0412934810GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

TREX1 MBTPS1 CYP4F12 TLR9 PTCHD3 BCAP29 CYP4F11 CYP4A11 RNF43 CYP4A22

6.19e-0412994810GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

TREX1 MBTPS1 CYP4F12 TLR9 PTCHD3 BCAP29 CYP4F11 CYP4A11 RNF43 CYP4A22

7.31e-0413274810GO:0042175
GeneOntologyCellularComponentapical plasma membrane

CYP4F12 TLR9 CYP4F11 CYP4A11 NPC1L1 CYP4A22

8.30e-04487486GO:0016324
MousePhenoincreased renal vascular resistance

CYP4A11 CYP4A22

8.76e-055422MP:0005531
MousePhenoabnormal renal sodium reabsorption

CYP4A11 CYP4A22

8.76e-055422MP:0010109
MousePhenoenlarged seminal vesicle

TREX1 CLUH ZNF746

1.18e-0432423MP:0002997
DomainCyt_P450_E_grp-I

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.29e-0645484IPR002401
DomainCyt_P450_CS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.02e-0553484IPR017972
DomainCYTOCHROME_P450

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.37e-0557484PS00086
Domain-

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.47e-05584841.10.630.10
Domainp450

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.47e-0558484PF00067
DomainCyt_P450

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.68e-0560484IPR001128
DomainPtc/Disp

PTCHD3 NPC1L1

2.30e-049482IPR003392
DomainPatched

PTCHD3 NPC1L1

2.30e-049482PF02460
DomainNTP_transf_2

TUT4 PAPOLA

3.51e-0411482PF01909
DomainPolymerase_NTP_transf_dom

TUT4 PAPOLA

3.51e-0411482IPR002934
DomainSSD

PTCHD3 NPC1L1

4.95e-0413482PS50156
DomainSSD

PTCHD3 NPC1L1

4.95e-0413482IPR000731
DomainSAM_1

CNKSR1 L3MBTL3 SHANK3

7.10e-0468483PF00536
DomainSAM

CNKSR1 L3MBTL3 SHANK3

1.50e-0388483SM00454
DomainSAM_DOMAIN

CNKSR1 L3MBTL3 SHANK3

1.87e-0395483PS50105
DomainTIR_dom

TLR9 IL17RD

1.87e-0325482IPR000157
DomainSAM

CNKSR1 L3MBTL3 SHANK3

1.98e-0397483IPR001660
Domain-

CNKSR1 L3MBTL3 SHANK3

2.55e-031064831.10.150.50
DomainSEMA

SEMA5B PLXNA2

2.87e-0331482PS51004
DomainSema

SEMA5B PLXNA2

2.87e-0331482SM00630
DomainSemap_dom

SEMA5B PLXNA2

2.87e-0331482IPR001627
DomainSema

SEMA5B PLXNA2

2.87e-0331482PF01403
DomainPlexin_repeat

SEMA5B PLXNA2

3.05e-0332482IPR002165
DomainPSI

SEMA5B PLXNA2

3.05e-0332482PF01437
DomainSAM/pointed

CNKSR1 L3MBTL3 SHANK3

3.38e-03117483IPR013761
DomainPSI

SEMA5B PLXNA2

5.71e-0344482IPR016201
DomainPSI

SEMA5B PLXNA2

6.23e-0346482SM00423
Domain-

TREX1 POLA1

6.49e-03474823.30.420.10
DomainLRR_6

TLR9 LRRC71

8.81e-0355482PF13516
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP4F12 CYP4F11 CYP4A11 CYP4A22

7.13e-0911324MM14863
PathwayREACTOME_EICOSANOIDS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.07e-0812324MM14845
PathwayREACTOME_EICOSANOIDS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.07e-0812324M27129
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.15e-0814324MM15842
PathwayREACTOME_FATTY_ACIDS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.93e-0815324M27126
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F12 CYP4F11 CYP4A11 CYP4A22

6.54e-0818324MM14843
PathwayREACTOME_FATTY_ACIDS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

6.54e-0818324MM14841
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.67e-0725324MM14858
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

CYP4F12 CYP4F11 CYP4A11 CYP4A22

8.54e-0733324MM15963
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4F12 CYP4F11 CYP4A11 CYP4A22

8.54e-0733324MM15918
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY

CYP4F12 CYP4A11 CYP4A22

8.84e-079323M39819
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F11 CYP4A11 CYP4A22

2.31e-0612323M27128
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.04e-0561324MM14861
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.11e-0562324M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.26e-0564324M5650
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F11 CYP4A11 CYP4A22

1.37e-0521323M27137
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.43e-0566324MM14839
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX

CYP4F12 CYP4A11 CYP4A22

3.73e-0529323M39858
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4F12 CYP4A11 CYP4A22

4.57e-0531323M39851
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

8.58e-05104324M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

8.90e-05105324MM14842
PathwayKEGG_MEDICUS_REFERENCE_DNA_DEGRADATION_BY_EXTRACELLULAR_ENDOLYSOSOMAL_DNASE

TREX1 DNASE2

1.04e-047322M47913
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP4F11 CYP4A11 CYP4A22

3.17e-0459323M27140
PathwayKEGG_PPAR_SIGNALING_PATHWAY

CYP4A11 PCK1 CYP4A22

5.03e-0469323M13088
PathwayREACTOME_FATTY_ACID_METABOLISM

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.64e-04170324MM15573
PathwayWP_PPAR_SIGNALING_PATHWAY

CYP4A11 PCK1 CYP4A22

5.93e-0473323MM15995
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.45e-03219324MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.47e-03220324M10320
PathwayREACTOME_METABOLISM_OF_LIPIDS

MBTPS1 CYP4F12 PIK3C2A CYP4F11 CYP4A11 CYP4A22

2.41e-03620326MM15193
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP4A11 CYP4A22

2.52e-0333322MM1448
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP4A11 CYP4A22

2.68e-0334322M16393
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

CNKSR1 IL17RD

3.51e-0339322MM15272
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

CNKSR1 IL17RD

3.69e-0340322M27557
PathwayKEGG_FATTY_ACID_METABOLISM

CYP4A11 CYP4A22

4.06e-0342322M699
Pubmed

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells.

TREX1 TLR9 DNASE2

4.92e-08648329706455
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP4F12 CYP4F11 CYP4A11 CYP4A22

4.16e-074448412745259
Pubmed

The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.

CYP4A11 CYP4A22

1.87e-0624822766933
Pubmed

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

CYP4A11 CYP4A22

1.87e-06248215611369
Pubmed

20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.

CYP4A11 CYP4A22

1.87e-06248223825080
Pubmed

Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

CYP4A11 CYP4A22

1.87e-06248216691295
Pubmed

Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.

CYP4A11 CYP4A22

1.87e-0624828031839
Pubmed

The P450 gene superfamily: recommended nomenclature.

CYP4A11 CYP4A22

1.87e-0624823829886
Pubmed

Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.

CYP4A11 CYP4A22

1.87e-06248210860550
Pubmed

Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.

CYP4A11 CYP4A22

1.87e-06248229277328
Pubmed

Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.

CYP4A11 CYP4A22

1.87e-06248217112342
Pubmed

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.

CYP4A11 CYP4A22

1.87e-06248221820496
Pubmed

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.

CYP4A11 CYP4A22

1.87e-06248211320253
Pubmed

Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.

CYP4A11 CYP4A22

1.87e-06248223641057
Pubmed

Characterization of the CYP4A11 gene, a second CYP4A gene in humans.

CYP4A11 CYP4A22

1.87e-06248212464262
Pubmed

Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.

CYP4A11 CYP4A22

1.87e-06248220943934
Pubmed

The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.

CYP4A11 CYP4A22

1.87e-06248228912346
Pubmed

High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.

CYP4A11 CYP4A22

1.87e-06248230088983
Pubmed

Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.

CYP4A11 CYP4A22

1.87e-06248215066132
Pubmed

Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.

CYP4A11 CYP4A22

1.87e-06248224413902
Pubmed

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

CYP4A11 CYP4A22

1.87e-06248219208908
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.74e-067048415128046
Pubmed

Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.

CYP4A11 CYP4A22

5.59e-06348228270609
Pubmed

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.

CYP4A11 CYP4A22

5.59e-0634821991046
Pubmed

Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.

CYP4A11 CYP4A22

5.59e-0634822354437
Pubmed

Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.

CYP4A11 CYP4A22

5.59e-06348219713718
Pubmed

Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.

CYP4A11 CYP4A22

5.59e-0634828011168
Pubmed

Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.

CYP4A11 CYP4A22

5.59e-06348215313227
Pubmed

H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.

CYP4A11 CYP4A22

5.59e-06348237659685
Pubmed

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

TREX1 TLR9

5.59e-06348223993650
Pubmed

A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.

CYP4A11 CYP4A22

5.59e-0634829271096
Pubmed

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

CYP4F12 CYP4F11

1.12e-05448218065749
Pubmed

DNase II-dependent DNA digestion is required for DNA sensing by TLR9.

TLR9 DNASE2

1.12e-05448225600358
Pubmed

Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.

CYP4F12 CYP4F11

1.12e-05448222665481
Pubmed

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

CYP4A11 CYP4A22

1.12e-0544828334987
Pubmed

Mapping of the azh locus to mouse chromosome 4.

CYP4A11 CYP4A22

1.12e-0544821552159
Pubmed

Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.

CYP4A11 CYP4A22

1.12e-05448222159897
Pubmed

Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

CYP4F12 CYP4F11

1.12e-05448211185557
Pubmed

Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.

CYP4A11 CYP4A22

1.12e-05448210049703
Pubmed

Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11.

CYP4A11 POLA1

1.12e-05448210660572
Pubmed

Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.

CYP4A11 CYP4A22

1.12e-05448221161333
Pubmed

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.

CYP4F12 CYP4F11

1.86e-05548222969154
Pubmed

Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.

CYP4A11 CYP4A22

1.86e-0554828363569
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

SEMA5B PLXNA2

1.86e-05548225313870
Pubmed

Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.

CYP4A11 CYP4A22

1.86e-05548220427718
Pubmed

Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.

CYP4A11 CYP4A22

1.86e-0554827601480
Pubmed

Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.

CYP4F12 CYP4F11

1.86e-05548221466787
Pubmed

Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences.

CYP4A11 PCK1 CYP4A22

2.01e-053848310501973
Pubmed

Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.

CYP4A11 CYP4A22

2.79e-0564828798505
Pubmed

Organization of the distal end of mouse chromosome 4.

CYP4A11 CYP4A22

2.79e-0564823166417
Pubmed

Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.

CYP4A11 CYP4A22

2.79e-05648228007964
Pubmed

The cytochrome P450 4 (CYP4) family.

CYP4F12 CYP4F11

2.79e-0564829068972
Pubmed

Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.

CYP4A11 CYP4A22

2.79e-0564828661721
Pubmed

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation.

TLR9 DNASE2

2.79e-05648216301743
Pubmed

Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.

CYP4A11 CYP4A22

2.79e-05648211461119
Pubmed

Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.

CYP4A11 CYP4A22

3.90e-05748212958197
Pubmed

Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.

CYP4A11 CYP4A22

3.90e-05748218648086
Pubmed

Molecular mapping of the mouse db mutation.

CYP4A11 CYP4A22

3.90e-0574821978328
Pubmed

Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.

TLR9 DNASE2

3.90e-05748220974942
Pubmed

Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.

CYP4F12 CYP4F11

3.90e-05748222160543
Pubmed

Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones.

CYP4A11 CYP4A22

5.19e-0584828098006
Pubmed

TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways.

TREX1 TLR9

5.19e-05848224598055
Pubmed

Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.

CYP4A11 CYP4A22

5.19e-05848218488193
Pubmed

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

CYP4A11 CYP4A22

6.67e-0594827678494
Pubmed

Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice.

CYP4A11 CYP4A22

6.67e-0594821685137
Pubmed

Genetic mapping of meander tail, a mouse mutation affecting cerebellar development.

CYP4A11 CYP4A22

8.33e-05104822037292
Pubmed

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.

TREX1 DNASE2

1.02e-041148226371324
Pubmed

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.

CYP4A11 CYP4A22

1.44e-041348232266253
Pubmed

Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.

SPAG17 PCNX3 LSG1

1.62e-047648336560452
Pubmed

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.

CYP4A11 CYP4A22

1.94e-041548229968852
Pubmed

Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.

CYP4A11 CYP4A22

2.21e-041648210087299
Pubmed

Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues.

CYP4A11 CYP4A22

2.21e-041648222154759
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP4A11 CYP4A22

2.50e-041748227197076
Pubmed

Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences.

CYP4A11 CYP4A22

2.81e-04184821387105
Pubmed

Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.

RNF43 HSF5

3.14e-041948225208829
Pubmed

A molecular genetic linkage map of mouse chromosome 2.

LTK PCK1

3.49e-04204821970329
Pubmed

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

SEMA5B PLXNA2

3.85e-042148221835343
Pubmed

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

RNF43 PCK1

3.85e-042148227088858
Pubmed

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.

TLR9 PIK3C2A

4.63e-042348219047410
Pubmed

Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.

CYP4A11 CYP4A22

5.05e-04244827873878
Pubmed

Molecular genetic linkage maps of mouse chromosomes 4 and 6.

CYP4A11 CYP4A22

5.93e-04264821684952
Pubmed

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

CYP4A11 CYP4A22

6.40e-042748228167773
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

SEMA5B PLXNA2

6.89e-042848218617019
Pubmed

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.

CYP4A11 CYP4A22

7.39e-042948228364022
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

IL17RD BCAP29 SZT2 PRCP LSG1

9.65e-0455248510737800
Pubmed

Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.

CYP4A11 CYP4A22

1.14e-03364829344654
InteractionCYP4A11 interactions

CYP4A11 POLA1 CYP4A22

1.18e-075473int:CYP4A11
InteractionCYP4A22 interactions

CYP4A11 CYP4A22

1.59e-053472int:CYP4A22
Cytoband1p33

CYP4A11 CYP4A22

6.23e-04354821p33
Cytoband17q22

RNF43 HSF5

9.85e-044448217q22
Cytoband19p13.1

CYP4F12 CYP4F11

1.17e-034848219p13.1
CytobandEnsembl 112 genes in cytogenetic band chr1p33

CYP4A11 CYP4A22

1.88e-0361482chr1p33
CytobandEnsembl 112 genes in cytogenetic band chr17q22

RNF43 HSF5

3.87e-0388482chr17q22
GeneFamilyCytochrome P450 family 4

CYP4F12 CYP4F11 CYP4A11 CYP4A22

3.50e-07363041003
GeneFamilySterile alpha motif domain containing

CNKSR1 L3MBTL3 SHANK3

4.11e-0488303760
ComputationalNeighborhood of GSTM1

CYP4F12 CYP4F11 CYP4A11 PCK1

1.47e-04109274GNF2_GSTM1
ComputationalNeighborhood of LCAT

CYP4F12 CYP4F11 CYP4A11 PCK1

2.41e-04124274GNF2_LCAT
ComputationalNeighborhood of HPN

CYP4F12 CYP4F11 CYP4A11 PCK1

3.24e-04134274GNF2_HPN
ComputationalNeighborhood of HPX

CYP4F12 CYP4F11 CYP4A11 PCK1

3.34e-04135274GNF2_HPX
DrugAC1L1BEQ

MBTPS1 CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.52e-0693485CID000001407
Drughexobarbital

CYP4F12 PTCHD3 CYP4F11 CYP4A11 CYP4A22

7.05e-06127485CID000003608
Drugpropoxyphene

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.21e-0567484CID000010100
Drugcarteolol

CYP4F12 CYP4F11 CYP4A11 CYP4A22

1.61e-0572484CID000002583
Drugtrimipramine

CYP4F12 CYP4F11 CYP4A11 CYP4A22

2.44e-0580484CID000005584
Drugdiosmetin

CYP4F12 CYP4F11 CYP4A11 CYP4A22

3.11e-0585484CID005281612
Drugmephenytoin

CYP4F12 CYP4F11 CYP4A11 CYP4A22

3.56e-0588484CID000004060
Drugtienilic acid

CYP4F12 CYP4F11 CYP4A11 CYP4A22

4.42e-0593484CID000038409
Druglansoprazole

CYP4F12 CYP4F11 CYP4A11 CYP4A22

4.42e-0593484CID000003883
DrugAC1L1KIN

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.88e-05100484CID000005516
DrugSparteinum

CYP4F12 CYP4F11 CYP4A11 CYP4A22

6.11e-05101484CID000003966
DrugCH2CN

CYP4F12 PTCHD3 SPAG17 HSF5

6.35e-05102484CID000137768
Drug3-hydroxystearate

CYP4F12 CYP4A11

9.08e-057482CID005282907
DiseaseAutoinflammatory disorder

TREX1 POLA1 DNASE2

2.55e-0535483C3860213
DiseaseX-14939 measurement

CYP4A11 CYP4A22

3.87e-056482EFO_0800747
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CYP4A11 CYP4A22

1.41e-0411482DOID:0110861 (biomarker_via_orthology)
DiseaseLupus Erythematosus, Systemic

TREX1 PCNX3 DNASE2

2.14e-0471483C0024141
Diseasehypertension (biomarker_via_orthology)

CYP4F12 CYP4F11 CYP4A11 CYP4A22

5.09e-04227484DOID:10763 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
QLLPLKPNLWCYLNP

APLF

71

Q8IW19
NTQNRQPFPALKPWL

C2orf78

661

A6NCI8
RQWLLKALQQFPCPP

CYP4A11

41

Q02928
IFCLPFIPPQRWQKI

BCAP29

21

Q9UHQ4
PQGILSKCLQWLQPR

ANKRD33

376

Q7Z3H0
VGCPLPLQKPLVNNW

PCK1

196

P35558
PLQKPLVNNWPCNPE

PCK1

201

P35558
KTQPLPQDPLWQCFL

RECK

251

O95980
FKSPIPCLPLRWEQQ

L3MBTL3

676

Q96JM7
PCLPLRWEQQSKLLP

L3MBTL3

681

Q96JM7
PQSVFLQCVPWRKPN

LRCOL1

106

A6NCL2
PDNLACKPFWKPRNL

IL17RD

191

Q8NFM7
ENKQFLCIPRRPNWN

LSG1

106

Q9H089
ACPRLSWAKPQPLNE

MBTPS1

926

Q14703
QGPCPTVRQKLWNIL

KCNV1

186

Q6PIU1
PLKSRGLQPQNLWNP

LTK

846

P29376
LRKQLPWFCLSQPVL

PCNX3

1101

Q9H6A9
NCLPLRFWVNVIKNP

PLXNA2

1741

O75051
PNCLPKILASAPNWK

PIK3C2A

906

O00443
NFLQPLPAWPIKVVC

PRCP

296

P42785
CLPPLTQLQAINLWK

LRRC71

161

Q8N4P6
PCWLEVKSPQLLNQP

POLA1

496

P09884
WPNPVLLKQPEECNL

PAPOLA

281

P51003
YLPWFLNDRPNIKCP

NPC1L1

1011

Q9UHC9
LCAQLPALWKAFQPL

DNASE2

326

O00115
RRLQCFPQPPKQNWF

CYP4F11

46

Q9HBI6
RQWLLKALQQFPCPP

CYP4A22

41

Q5TCH4
RRLQCFPQPPKRNWF

CYP4F12

46

Q9HCS2
IFRPNQQKPLPVSRW

MAN2B1

661

O00754
WKRLLLCDFAEQPPP

C9orf40

16

Q8IXQ3
LCVPPNPILYAWQVN

PTCHD3

261

Q3KNS1
LKPLISAQPPQWRCY

SZT2

1111

Q5T011
PNNFPAKLWRLVNSP

HSF5

11

Q4G112
NSQPVWLCLTPRQPL

RNF43

721

Q68DV7
LQFPLPPPWNNTKRL

SPAG17

561

Q6Q759
FRWPQCVPNNLKTLI

CILK1

236

Q9UPZ9
WQLPGKNLLQLCPQS

CNKSR1

31

Q969H4
ERPLCPLQPQNRDWK

CLUH

196

O75153
PLQPQNRDWKPLQCL

CLUH

201

O75153
PRRPFQQKPLQLWSK

SHANK3

1656

Q9BYB0
LPSLRHLNLKWNCPP

TLR9

86

Q9NR96
CPTNFWQQQPLVLPA

TBX22

376

Q9Y458
NTWEPLQNLKCPLLL

SUV39H2

76

Q9H5I1
QLWRAQPAAILPCLK

USP35

201

Q9P2H5
PWVLPLQNFEARKIP

ZNF774

51

Q6NX45
AAWLPIANPIPNFQC

SEMA5B

411

Q9P283
WNFRCKPPVGLNPRT

ZNF746

381

Q6NUN9
CPSQRLQWPGKEPQV

WDR25

91

Q64LD2
LWKALPNCSFPNLQR

TTC39C

456

Q8N584
QQRKPPLLPCLLGSW

TUT4

531

Q5TAX3
NLLLAFLRRQPQPWC

TREX1

106

Q9NSU2