Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontriplex DNA binding

DDX12P DDX11 DDX11L8

4.86e-0741003GO:0045142
GeneOntologyMolecularFunction5'-3' DNA helicase activity

DDX12P DDX11 DDX11L8

1.95e-05111003GO:0043139
GeneOntologyMolecularFunctionG-quadruplex DNA binding

DDX12P DDX11 DDX11L8

4.26e-05141003GO:0051880
GeneOntologyMolecularFunctionDNA replication origin binding

DDX12P DDX11 DDX11L8

9.42e-05181003GO:0003688
GeneOntologyBiologicalProcessestablishment of sister chromatid cohesion

DDX12P DDX11 DDX11L8

1.77e-05111003GO:0034085
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

ROBO4 PCDHB8 PCDHB4 DSCAML1 CELSR1 PTPRM PKD1

3.54e-051871007GO:0007156
GeneOntologyBiologicalProcessbranching involved in lymph vessel morphogenesis

TIE1 PKD1

6.96e-0531002GO:0060854
GeneOntologyCellularComponentCtf18 RFC-like complex

DDX12P DDX11 DDX11L8

1.17e-0510983GO:0031390
MousePhenoincreased allantois apoptosis

DDX12P DDX11 DDX11L8

9.90e-068803MP:0003891
MousePhenoabsent paraxial mesoderm

DDX12P DDX11 DDX11L8

1.48e-059803MP:0012184
MousePhenodecreased paraxial mesoderm size

DDX12P DDX11 DDX11L8

3.83e-0512803MP:0012183
MousePhenosmall allantois

DDX12P DDX11 DDX11L8

9.58e-0516803MP:0004559
MousePhenoabnormal cardiovascular development

CARM1 ROBO4 ISYNA1 DDX12P ELP1 GXYLT1 MEIS2 DDX11 NCOR2 TIE1 SETD5 PKD1 DAAM1 DDX11L8

1.64e-048028014MP:0002925
MousePhenoplacental labyrinth hypoplasia

DDX12P DDX11 DDX11L8

1.92e-0420803MP:0001715
MousePhenovertebral body hypoplasia

NKX3-2 PAX1

1.93e-044802MP:0004667
MousePhenoabnormal ventral tubercle of atlas morphology

NKX3-2 PAX1

1.93e-044802MP:0004658
MousePhenovertebral compression

NKX3-2 PAX1

1.93e-044802MP:0004626
Domainfn3

ROBO4 MYOM1 INSRR DSCAML1 LRRN4CL TIE1 PTPRM UMODL1

2.19e-06162988PF00041
DomainFN3

ROBO4 MYOM1 INSRR DSCAML1 LRRN4CL TIE1 PTPRM UMODL1

5.86e-06185988SM00060
DomainFN3

ROBO4 MYOM1 INSRR DSCAML1 LRRN4CL TIE1 PTPRM UMODL1

1.00e-05199988PS50853
DomainFN3_dom

ROBO4 MYOM1 INSRR DSCAML1 LRRN4CL TIE1 PTPRM UMODL1

1.43e-05209988IPR003961
DomainGrowth_fac_rcpt_

INSRR IGFBPL1 LRP8 CELSR1 FBLN2 TIE1 UMODL1

1.81e-05156987IPR009030
DomainEGF_3

BCAN SSPOP LRP8 CELSR1 FBLN2 TIE1 UMODL1 AGRN

3.31e-05235988PS50026
DomainEGF

BCAN LRP8 CELSR1 FBLN2 FCGBP TIE1 UMODL1 AGRN

3.31e-05235988SM00181
DomainEGF-like_dom

BCAN LRP8 CELSR1 FBLN2 FCGBP TIE1 UMODL1 AGRN

4.99e-05249988IPR000742
DomainEGF_1

BCAN SSPOP LRP8 CELSR1 FBLN2 TIE1 UMODL1 AGRN

5.90e-05255988PS00022
DomainEGF_2

BCAN SSPOP LRP8 CELSR1 FBLN2 TIE1 UMODL1 AGRN

7.73e-05265988PS01186
DomainTACC

TACC2 TACC1

8.15e-053982PF05010
DomainTACC

TACC2 TACC1

8.15e-053982IPR007707
DomainREJ

PKD1L2 PKD1

1.62e-044982PS51111
DomainREJ_dom

PKD1L2 PKD1

1.62e-044982IPR014010
DomainPKD/REJ-like

PKD1L2 PKD1

4.03e-046982IPR002859
DomainREJ

PKD1L2 PKD1

4.03e-046982PF02010
DomainEGF-like_CS

BCAN LRP8 CELSR1 FBLN2 TIE1 UMODL1 AGRN

4.50e-04261987IPR013032
DomainEGF_CA

LRP8 CELSR1 FBLN2 UMODL1 AGRN

4.58e-04122985SM00179
DomainEGF-like_Ca-bd_dom

LRP8 CELSR1 FBLN2 UMODL1 AGRN

4.94e-04124985IPR001881
DomainEGF

BCAN LRP8 CELSR1 TIE1 AGRN

5.31e-04126985PF00008
Domain-

ROBO4 MYOM1 INSRR BCAN DSCAML1 IGFBPL1 LRRN4CL TIE1 PTPRM UMODL1 VSIG10L

7.06e-0466398112.60.40.10
DomainGPS

PKD1L2 CELSR1 PKD1

7.45e-0434983SM00303
DomainGPS

PKD1L2 CELSR1 PKD1

8.12e-0435983PF01825
DomainGPS

PKD1L2 CELSR1 PKD1

8.82e-0436983PS50221
DomainGPS

PKD1L2 CELSR1 PKD1

9.56e-0437983IPR000203
DomainIg-like_fold

ROBO4 MYOM1 INSRR BCAN DSCAML1 IGFBPL1 LRRN4CL TIE1 PTPRM UMODL1 VSIG10L

1.18e-037069811IPR013783
DomainGlyco_transf_8

GXYLT1 GYG2

1.19e-0310982PF01501
DomainGlyco_trans_8

GXYLT1 GYG2

1.19e-0310982IPR002495
DomainFol_N

FCGBP AGRN

1.45e-0311982IPR003645
DomainPKD_channel

PKD1L2 PKD1

1.45e-0311982PF08016
DomainFOLN

FCGBP AGRN

1.45e-0311982SM00274
DomainPKD1_2_channel

PKD1L2 PKD1

1.45e-0311982IPR013122
DomainIG

ROBO4 MYOM1 BCAN DSCAML1 IGFBPL1 TIE1 PTPRM VSIG10L

1.68e-03421988SM00409
DomainIg_sub

ROBO4 MYOM1 BCAN DSCAML1 IGFBPL1 TIE1 PTPRM VSIG10L

1.68e-03421988IPR003599
DomainTIL

SSPOP FCGBP

1.74e-0312982PF01826
DomainC8

SSPOP FCGBP

1.74e-0312982PF08742
DomainASX_HYDROXYL

LRP8 CELSR1 FBLN2 UMODL1

1.90e-03100984PS00010
DomainLDLRA_1

SSPOP LRP8 PKD1

2.04e-0348983PS01209
DomainUnchr_dom_Cys-rich

SSPOP FCGBP

2.05e-0313982IPR014853
DomainC8

SSPOP FCGBP

2.05e-0313982SM00832
DomainLDLRA_2

SSPOP LRP8 PKD1

2.17e-0349983PS50068
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP8 CELSR1 FBLN2 UMODL1

2.35e-03106984IPR000152
DomainTIL_dom

SSPOP FCGBP

2.38e-0314982IPR002919
DomainVWD

SSPOP FCGBP

3.12e-0316982SM00216
DomainVWF_type-D

SSPOP FCGBP

3.12e-0316982IPR001846
DomainVWFD

SSPOP FCGBP

3.12e-0316982PS51233
DomainVWD

SSPOP FCGBP

3.12e-0316982PF00094
DomainEMI

SSPOP UMODL1

3.52e-0317982PS51041
Domain-

CARM1 TRMT44 MEPCE CAMKMT

3.68e-031209843.40.50.150
DomainSAM-dependent_MTases

CARM1 TRMT44 MEPCE CAMKMT

3.90e-03122984IPR029063
DomainLH2

PKD1L2 PKD1

3.95e-0318982SM00308
DomainVWC_out

SSPOP FCGBP

4.40e-0319982SM00215
DomainIg-like_dom

ROBO4 MYOM1 BCAN DSCAML1 IGFBPL1 TIE1 PTPRM VSIG10L

4.96e-03503988IPR007110
Pubmed

Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.

DDX12P DDX11 DDX11L8

2.52e-083103317611414
Pubmed

Mammalian ChlR1 has a role in heterochromatin organization.

DDX12P DDX11 DDX11L8

2.52e-083103321854770
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SH3RF1 TASP1 KIFC2 CABLES1 GGA3 ZCCHC14 NHSL1 LIME1 NCOR2 CELSR1 SETD5 GLI1 PKD1 TNKS1BP1 NLGN2 AGRN

1.63e-0711051031635748872
Pubmed

The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.

DDX12P DDX11 DDX11L8

1.40e-068103322678773
Pubmed

Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon.

TACC2 TACC1

8.69e-062103210435627
Pubmed

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.

DDX12P DDX11

8.69e-062103232855419
Pubmed

Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA.

DDX12P DDX11

8.69e-06210328833153
Pubmed

Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.

DDX12P DDX11

8.69e-06210329013641
Pubmed

Cooperative activity of noggin and gremlin 1 in axial skeleton development.

NKX3-2 GLI1 PAX1

2.36e-0519103321303853
Pubmed

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.

TACC2 TACC1

2.60e-053103211121038
Pubmed

The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer.

TACC2 TACC1

2.60e-053103215226440
Pubmed

SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.

FZD9 CELSR1 DAAM1

2.77e-0520103332511952
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

CABLES1 LRP8 FARP2 NHSL1 CNNM3 TBC1D10B PTPRM DAAM1

3.76e-05421103836976175
Pubmed

Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms.

TACC2 TACC1

5.19e-054103215207008
Pubmed

Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1.

NKX3-2 PAX1

5.19e-054103214504237
Pubmed

The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.

TACC2 TACC1

5.19e-054103210366448
Pubmed

The mouse bagpipe gene controls development of axial skeleton, skull, and spleen.

NKX3-2 PAX1

5.19e-054103210449756
Pubmed

The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.

BCAN FBLN2

8.64e-055103211038354
Pubmed

Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.

NKX3-2 PAX1

8.64e-055103225902370
Pubmed

Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter.

NKX3-2 PAX1

8.64e-055103215024065
Pubmed

Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.

MEIS2 HOXA4 PAX1

8.72e-0529103333298461
Pubmed

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.

BCAN LRP8 CELSR1 DAAM1

1.06e-0482103431073041
Pubmed

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

DDX12P DDX11 DDX11L8

1.29e-0433103315755804
Pubmed

Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome.

NKX3-2 PAX1

1.29e-046103212490554
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TACC2 CABLES1 TBC1D4 HNRNPUL2 MCRS1 TNKS1BP1 MTCL1 TP53BP1

1.30e-04503103816964243
Pubmed

The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.

TACC2 TACC1

1.81e-047103214767476
Pubmed

PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis.

NKX3-2 GLI1

1.81e-047103235858546
Pubmed

Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.

TACC2 TACC1

2.40e-048103214602875
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SH3RF1 ZCCHC14 NHSL1 WWC2 TBC1D10B FAM117A TBC1D4 MEPCE TNKS1BP1 MTCL1

2.43e-048611031036931259
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

ROBO4 INSRR LRP8 WWC2 TIE1 GPR149 MTBP

2.61e-04420103728065597
Pubmed

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.

CARM1 MEIS2 NCOR2 GLI1 PAX1

2.68e-04191103524146773
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

ISYNA1 SH3RF1 GGA3 NHSL1 TBC1D10B VSIG10L TNKS1BP1 DAAM1

2.84e-04565103825468996
Pubmed

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.

LRP8 AGRN

3.08e-049103223986861
Pubmed

Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton.

NKX3-2 PAX1

3.08e-04910329256352
Pubmed

Impaired intervertebral disc formation in the absence of Jun.

NKX3-2 PAX1

3.08e-049103212441295
Pubmed

A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc).

GLI1 PAX1

3.08e-049103211784021
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CARM1 SSPOP DSCAML1 CABLES1 MYO15B TBC1D4 PKD1 MTCL1 FBXO34

3.47e-04736103929676528
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

SH3RF1 ELP1 TACC2 DDX11 NCOR2 TBC1D4 TNKS1BP1 TP53BP1

3.71e-04588103838580884
Pubmed

TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes.

NKX3-2 PAX1

3.85e-0410103212646629
Pubmed

Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.

PKD1L2 PKD1

3.85e-0410103216805797
Pubmed

Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation.

NKX3-2 PAX1

3.85e-0410103210886375
Pubmed

Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction.

GLI1 PAX1

3.85e-0410103214602680
Pubmed

Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.

GLI1 PAX1

3.85e-0410103212223417
Pubmed

Bapx1 homeobox gene gain-of-function mice show preaxial polydactyly and activated Shh signaling in the developing limb.

NKX3-2 GLI1

3.85e-0410103216791844
Pubmed

High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays.

TACC2 TACC1 MTCL1

4.47e-0450103329560723
Pubmed

The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen.

NKX3-2 PAX1

4.69e-0411103210572046
Pubmed

Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.

ROBO4 MYOM1

4.69e-0411103224355925
Pubmed

Sox9 is required for notochord maintenance in mice.

NKX3-2 PAX1

4.69e-0411103216678811
Pubmed

Sonic hedgehog is required for cardiac outflow tract and neural crest cell development.

GLI1 PAX1

4.69e-0411103215936751
Pubmed

Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects.

CELSR1 DAAM1

4.69e-0411103234274973
Pubmed

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms.

GLI1 PAX1

4.69e-0411103216712836
Pubmed

FBXO22 degrades nuclear PTEN to promote tumorigenesis.

ELP1 GPKOW CLCC1

5.31e-0453103332249768
Pubmed

Strain-specific modifier genes governing craniofacial phenotypes.

TIE1 DAAM1

5.62e-0412103222371338
Pubmed

Pancreatic Mesenchyme Regulates Islet Cellular Composition in a Patched/Hedgehog-Dependent Manner.

NKX3-2 GLI1

5.62e-0412103227892540
Pubmed

Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.

MEIS2 GLI1

5.62e-0412103231767679
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

SH3RF1 SSPOP DSCAML1 TBC1D4

6.19e-04130103412421765
Pubmed

An empirical framework for binary interactome mapping.

CNNM3 TIE1 SETD5 MCRS1 C8orf33

6.39e-04231103519060904
Pubmed

Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.

FBLN2 AGRN

6.63e-0413103212682087
Pubmed

Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.

CELSR1 DAAM1

6.63e-0413103217229766
Pubmed

Protocadherins.

PCDHB8 PCDHB4

6.63e-0413103212231349
Pubmed

Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplication.

FZD9 PAX1

6.63e-0413103211455436
Pubmed

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

CELSR1 DAAM1

6.63e-0413103226989192
Pubmed

Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.

TACC2 TACC1

6.63e-0413103217920017
Pubmed

Development of the Proximal-Anterior Skeletal Elements in the Mouse Hindlimb Is Regulated by a Transcriptional and Signaling Network Controlled by Sall4.

MEIS2 GLI1

7.72e-0414103232156750
Pubmed

Rostral and caudal pharyngeal arches share a common neural crest ground pattern.

HOXA4 PAX1

7.72e-0414103219168678
Pubmed

Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula.

NKX3-2 MEIS2

7.72e-0414103223473983
Pubmed

Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling.

NKX3-2 GLI1

7.72e-0414103212163410
Pubmed

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development.

SIM2 PAX1

7.72e-0414103228011632
Pubmed

Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.

GLI1 PAX1

8.89e-0415103215604102
Pubmed

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

TIE1 PAX1

8.89e-0415103210051567
Pubmed

Pax: a murine multigene family of paired box-containing genes.

HOXA4 PAX1

8.89e-041510321685142
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

SSPOP CELSR1

8.89e-0415103220473291
Pubmed

Twist1 activity thresholds define multiple functions in limb development.

GLI1 PAX1

8.89e-0415103220732316
Pubmed

Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal protein expression.

NKX3-2 PAX1

8.89e-0415103227986952
Pubmed

Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.

NKX3-2 PAX1

8.89e-0415103219520072
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

SSPOP FBLN2 AGRN

9.22e-0464103322261194
Pubmed

Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.

GPR27 RFXAP

1.01e-0316103225113059
Pubmed

Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation.

NKX3-2 PAX1

1.01e-0316103217477400
Pubmed

Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies.

GLI1 PAX1

1.01e-0316103222228095
Pubmed

Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.

NKX3-2 PAX1

1.01e-0316103227381226
Pubmed

Tie2 regulates endocardial sprouting and myocardial trabeculation.

ROBO4 HOXA4 TIE1

1.10e-0368103331112136
Pubmed

SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling.

MEIS2 GLI1

1.15e-0317103221471156
Pubmed

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.

GLI1 PAX1

1.15e-0317103225356765
Pubmed

DNA sequence and analysis of human chromosome 18.

CABLES1 MTCL1

1.15e-0317103216177791
Pubmed

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.

CARM1 NCOR2

1.15e-0317103219183483
Pubmed

Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.

PCDHB8 PCDHB4

1.15e-0317103218279309
Pubmed

The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells.

GLI1 PAX1

1.15e-0317103225299669
Pubmed

Hedgehog regulation of epithelial cell state and morphogenesis in the larynx.

GLI1 PAX1

1.15e-0317103236398878
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

GPKOW MEIS2 NCOR2 TBC1D4 TNKS1BP1 TP53BP1

1.23e-03399103635987950
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

SSPOP EPG5 TP53BP1

1.25e-0371103333541421
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

SH3RF1 TACC2 MEIS2 ZCCHC14 GLI1 MCRS1 PAX1 PJA1

1.25e-03709103822988430
Pubmed

Genome-wide association of mood-incongruent psychotic bipolar disorder.

FBLN2 TRANK1

1.29e-0318103223092984
Pubmed

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.

HOXA4 GLI1

1.29e-0318103230352852
Pubmed

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.

HNRNPUL2 PKD1 TP53BP1

1.30e-0372103333106477
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHB8 PCDHB4 CELSR1

1.30e-0372103310380929
Pubmed

Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting.

PCDHB8 PCDHB4

1.44e-0319103228066179
Pubmed

Gas1 extends the range of Hedgehog action by facilitating its signaling.

GLI1 PAX1

1.44e-0319103217504940
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHB8 PCDHB4 CELSR1

1.57e-0377103310835267
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

CARM1 ELP1 CNNM3 DAAM1 PJA1

1.57e-03283103521903422
Pubmed

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.

NKX3-2 PAX1

1.59e-0320103211517919
GeneFamilyFibronectin type III domain containing

ROBO4 MYOM1 INSRR DSCAML1 LRRN4CL TIE1 PTPRM

1.09e-06160617555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

ROBO4 MYOM1 DSCAML1 IGFBPL1 PTPRM

2.09e-04161615593
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

BCAN PKD1L2 PKD1

3.56e-04416131298
GeneFamilyGlycosyltransferase family 8

GXYLT1 GYG2

3.97e-049612436
CoexpressionHEVNER_CORTEX_CAUDAL_VENTRICULAR_ZONE

BCAN FZD9 NCOR2 TBC1D4 SETD5

1.91e-06521035MM442
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

INSRR NKX3-2 SIM2 IGFBPL1 HOXA4 CELSR1 INSM2 PAX1

1.23e-052721038M1938
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

INSRR NKX3-2 SIM2 IGFBPL1 HOXA4 CELSR1 INSM2 PAX1

1.60e-052821038MM822
CoexpressionXIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_708_5P_GENES

DDX12P DDX11 DDX11L8 TP53BP1

4.16e-05491034MM17508
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SH3RF1 GPR27 TACC2 NYX PANK1 WWC2

2.02e-0615910468680b054622f573a82b1625fb93c2d5db81d1034
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 NKX3-2 MEIS2 TIE1 PTPRM TACC1

5.15e-06187104635c382c0aabd46906113e5db30ea24bb8e658899
ToppCellEndothelial-A-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ROBO4 MEIS2 DDX11 HOXA4 FBLN2 TIE1

6.35e-061941046e656ac5539e59e321b46706cb8cc423b2c3358a0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 FBLN2 TIE1 PTPRM TACC1

6.35e-061941046b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 NHSL1 TIE1 PTPRM TACC1

7.14e-0619810461378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

STIMATE ELP1 ALKAL2 GLI1 PAX1

2.09e-05142104561eefa32926a057e53747633bf4a81f09ea721c5
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-Naive_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

CARM1 ALKAL2 DSCAML1 FBLN2 GLI1

3.18e-0515510451020da8a2c30384d962fa204a030299fdfcbbf98
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CERK BCAN ALKAL2 TNFRSF12A GPR149

3.59e-051591045c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RASGRP4 BCAN PTGER3 MEIS2 TIE1

3.59e-051591045ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RASGRP4 BCAN PTGER3 MEIS2 TIE1

3.59e-0515910457b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CLCC1 WWC2 FBLN2 TIE1 MTCL1

3.70e-051601045c61869d9dbba250270e59366e15af204e5b4395d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 FBLN2 TIE1 MTBP

4.04e-0516310451feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MEIS2 FZD9 CELSR1 TBC1D4 LRRN4CL

4.16e-0516410454cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MEIS2 FZD9 CELSR1 TBC1D4 LRRN4CL

4.16e-0516410457a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MEIS2 FZD9 CELSR1 TBC1D4 LRRN4CL

4.16e-0516410455e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MEIS2 FZD9 CELSR1 TBC1D4 LRRN4CL

4.16e-051641045f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GPKOW SSPOP VSIG10L TNKS1BP1 DAAM1

4.80e-051691045c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SSPOP LINC00528 VSIG10L TNKS1BP1 LOXL3

4.80e-051691045ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

SH3RF1 TACC2 WWC2 PTPRM TACC1

4.94e-051701045e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellNS-critical-d_0-4-Lymphoid-B_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TASP1 GPKOW RFXAP TUBGCP6 SHISAL2A

5.08e-051711045bd1ebd9037a740ad8c01c460d778b0973d8b56df
ToppCell368C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

MYOM1 TASP1 ZCCHC14 MYO15B TP53BP1

5.08e-051711045f3bf5805823d5733b58742172e7668725ce82931
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ISYNA1 BCAN MEIS2 FAM117A VSIG10L

5.22e-0517210457fb43b3938b9a3b6935ec22d9d853e7d47b82b3c
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCDHB4 MEIS2 FZD9 FBLN2 TIE1

5.22e-0517210459a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SIM2 FARP2 FZD9 CAMKMT LOXL3

5.66e-051751045a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SIM2 FARP2 FZD9 CAMKMT LOXL3

5.66e-0517510458b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ISYNA1 PTGER3 FZD9 PTPRM PDZD4

5.98e-0517710453a85aa2bf3f2fdbea57d22d68e022cb3f6c2eb65
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MEIS2 FBLN2 TIE1 PTPRM TACC1

6.30e-0517910451ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellmetastatic_Brain-Endothelial_cells-Lymphatic_ECs|metastatic_Brain / Location, Cell class and cell subclass

ROBO4 CNNM3 LRRN4CL TRMT44 TIE1

6.30e-05179104556fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TACC2 DSCAML1 KIFC2 CELSR1 MTCL1

6.30e-05179104504ce3673e46606f63d9c87bcba3a64c96817d812
ToppCelldroplet-Fat-Gat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 DDX11 TUBGCP6 TRMT44 TIE1

6.30e-05179104508cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ALKAL2 CABLES1 TNKS1BP1 LOXL3

6.44e-0592104484ac97a16920b912a67ea80e71146eddf9dfa92f
ToppCellwk_08-11-Mesenchymal-Fibroblast-Mesenchymal_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

BCAN PTGER3 MEIS2 HOXA4 LRRN4CL

6.64e-0518110457e3bcfa2ba5b98a7df5854aa6e7a31e9a71faa8a
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DSCAML1 KIFC2 WWC2 CELSR1 AGRN

6.64e-051811045b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBPL1 MEIS2 FBLN2 LRRN4CL SHISAL2A

6.64e-051811045c26d3cbbc592299786d79d1b15fc6bead2aafb9a
ToppCellcritical-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

BCAN MEIS2 FBLN2 TIE1 MTCL1

6.64e-051811045f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA4 FZD9 FBLN2 TIE1 PTPRM

7.00e-05183104512e876d6205af8aad74265c668b5e95b9e7487f3
ToppCellwk_15-18-Epithelial-PNS-intermediate_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

STIMATE ADCK2 BCAN TNFRSF12A FBLN2

7.00e-051831045d874aa9a856f79626c8a8371f6196a77b7d662ee
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKD1L2 SSPOP DSCAML1 TRANK1 DNAH9

7.18e-0518410452cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKD1L2 SSPOP DSCAML1 TRANK1 DNAH9

7.18e-051841045ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKD1L2 SSPOP DSCAML1 TRANK1 DNAH9

7.18e-0518410452b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

INSRR FCGBP LRRN4CL GLI1

7.30e-059510443699ea16660a22ea79fecfea56ece2dfb0f13467
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

INSRR FCGBP LRRN4CL GLI1

7.30e-05951044cbfe615d880913bafaf5e7e8d24c3ec14a9351ce
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

INSRR FCGBP LRRN4CL GLI1

7.30e-0595104427ac23b87747434a3084cc087e7b884e68f0eab9
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COG8 CABLES1 NHSL1 CELSR1 MEPCE

7.37e-051851045636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SH3RF1 MEIS2 DDX11 CNNM3 TRMT44

7.56e-051861045799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEIS2 ZCCHC14 NHSL1 FBLN2 TIE1

7.56e-0518610451e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D122|Adult / Lineage, Cell type, age group and donor

ROBO4 SHROOM2 TIE1 PTPRM MTCL1

7.95e-05188104502a62888e9db29d20133eeca1686d302545a39c9
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ROBO4 ISYNA1 SSPOP FZD9 TIE1

7.95e-051881045524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ROBO4 ISYNA1 SSPOP FZD9 TIE1

7.95e-051881045d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

MYOM1 TACC2 MEIS2 TBC1D4 PTPRM

8.15e-0518910455e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TACC2 ALKAL2 TNFRSF12A TRANK1 MTCL1

8.15e-051891045da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

8.35e-051901045656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 SH3RF1 MEIS2 WWC2 TIE1

8.56e-0519110451924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GPR27 NKX3-2 SIM2 FZD9 PAX1

8.56e-051911045273c4a757292a9301de0eaeacdec91c9866be229
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 SH3RF1 MEIS2 WWC2 TIE1

8.56e-05191104588f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

8.77e-0519210451ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 PTGER3 FCGBP TBC1D4 TACC1

8.77e-051921045ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MEIS2 FBLN2 TIE1 PTPRM TACC1

8.99e-0519310452e72309607902dabe3218888b22a77fe941f3570
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

8.99e-051931045287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.21e-051941045f76808666fb875fc787751cbfd924d9be20a8192
ToppCell10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ROBO4 SHROOM2 TIE1 PTPRM AGRN

9.21e-0519410458a4be91414a2e69dd410aa75791f16008204c9a1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.21e-051941045f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 NHSL1 TIE1 PTPRM

9.21e-051941045e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX3-2 BCAN PTGER3 MEIS2 LRRN4CL

9.44e-05195104519347b7e8d3ea67e0fddd948078abcab9d364a2d
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX3-2 BCAN PTGER3 MEIS2 LRRN4CL

9.44e-05195104555b4030f078173b0136990fae87b6eaf44c58f33
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MEIS2 FBLN2 TIE1 PTPRM TACC1

9.44e-05195104577e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|kidney / Disease (COVID-19 only), tissue and cell type

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.67e-051961045ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.67e-0519610454cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.67e-05196104522767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.67e-051961045d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 FBLN2 TIE1 PTPRM

9.67e-051961045145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.67e-051961045adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

9.90e-0519710450f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

INSRR BCAN PTGER3 FBLN2 GLI1

9.90e-05197104544673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 FBLN2 TIE1 PTPRM

1.01e-041981045b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ROBO4 TBC1D4 TIE1 TACC1 AGRN

1.01e-0419810450a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

1.01e-041981045451003a21162eeae90739fdb502bb50b362d80c8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 FBLN2 TIE1 PTPRM

1.01e-041981045953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

ROBO4 MEIS2 TIE1 PTPRM TACC1

1.01e-0419810458689090bce9ab6e8f122426a404037e572c6713b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

1.01e-041981045440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 TIE1 PTPRM TACC1

1.01e-0419810450a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 FBLN2 TIE1 PTPRM

1.01e-0419810458e45551224fbb30c0658ad47dd98335ecf165437
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SH3RF1 TACC2 NHSL1 WWC2 CELSR1

1.04e-0419910455f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SH3RF1 TACC2 NHSL1 WWC2 PTPRM

1.04e-041991045725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SH3RF1 TACC2 NHSL1 WWC2 CELSR1

1.04e-0419910455cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ROBO4 SHROOM2 TIE1 PTPRM AGRN

1.04e-0419910451c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYOM1 PTGER3 MEIS2 LRRN4CL AGRN

1.04e-041991045eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ROBO4 ALKAL2 LRP8 TIE1 AGRN

1.04e-0419910451295f34a350bf48987e2fad411aaac3630efd3f1
ToppCelldistal-2-Endothelial-Artery|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MEIS2 FBLN2 PTPRM TNKS1BP1 TACC1

1.04e-041991045fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 MEIS2 FBLN2 TIE1 PTPRM

1.04e-04199104533f1669eeb701986b4dec409efdb6c06c3c41c2b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Cortical_neuron|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ISYNA1 IGFBPL1 MEIS2 LRP8 DAAM1

1.06e-0420010457bba2ff09349c8db3d1ccf53520b12cbf7b0abac
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

BCAN MEIS2 FBLN2 TIE1 TACC1

1.06e-04200104577ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

MEIS2 FBLN2 TIE1 PTPRM DAAM1

1.06e-042001045b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MEIS2 FBLN2 TIE1 TACC1 DAAM1

1.06e-042001045b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pax5_(SN/VTA_(SNr))--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

INSRR LIME1 UMODL1

2.58e-04531043ef2fa0364d7807cec2c0a45f940837cac6d22e43
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pax5_(SN/VTA_(SNr))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

INSRR LIME1 UMODL1

2.58e-04531043974757404e411d7a0d762d21db07f9632a838be3
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pax5_(SN/VTA_(SNr))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

INSRR LIME1 UMODL1

2.58e-04531043ad3eac1ffca39ace1ea1284441c60fe55b1a8470
ToppCellTCGA-Uvea|World / Sample_Type by Project: Shred V9

CABLES1 FZD9 LRRN4CL GYG2

3.33e-041411044015451a83087f2705d3315ebc8f23797c6f10ed6
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRN4CL GPR149 VSIG10L SHISA8

4.43e-041521044af7dce8a7694e853b90f96fb2ca55ad7c8a1676b
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GPR27 PANK1 FZD9 NCOR2

4.43e-041521044ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
DiseaseWarsaw breakage syndrome (implicated_via_orthology)

DDX12P DDX11 DDX11L8

3.66e-083993DOID:0060535 (implicated_via_orthology)
Diseasehereditary lymphedema (is_implicated_in)

CELSR1 TIE1

2.31e-047992DOID:0050580 (is_implicated_in)
DiseaseMalignant neoplasm of breast

ELP1 TACC2 SHROOM2 GGA3 EPG5 HOXA4 ZCCHC14 GLI1 DNAH9 TP53BP1 PDZD4

9.57e-0410749911C0006142
Diseaseleukemia (implicated_via_orthology)

MEIS2 HOXA4

1.84e-0319992DOID:1240 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
APVSVSCGGESPLDG

TACC1

581

O75410
SGQFTSRPGACPAEG

UMODL1

111

Q5DID0
GGEARPCVGDSAVTP

EPG5

106

Q9HCE0
RCSGAAGAGPAESLP

ADCK2

71

Q7Z695
GCQVERGGPAATPSP

C1orf167

236

Q5SNV9
VRPSCSGAAAAGALP

CXorf49;

296

A8MYA2
AAAAPGPGTPCASRG

C8orf33

11

Q9H7E9
GGGRAASVPCSVAPE

FAM117A

61

Q9C073
NPVGSVSVDCGPSRA

FBXO34

341

Q9NWN3
DPATGQCSCRPGVGG

AGRN

806

O00468
CASPGSVVLGHGAPR

LINC00528

61

Q8N1L1
RVVASGVPRSCSGPG

BTBD11

251

A6QL63
SGGPDCAITVKSPGR

CELSR1

2971

Q9NYQ6
QAEGGGACPGLATTP

C17orf113

101

A0A1B0GUU1
GACPGLATTPASRGV

C17orf113

106

A0A1B0GUU1
AAPLAAGACPGGRSI

MTCL1

271

Q9Y4B5
KGPVPAATNGCTGDA

ISYNA1

531

Q9NPH2
VSGEATGADAGRLCP

NOBOX

146

O60393
ASRGGVAVVPASGDC

BCAN

636

Q96GW7
ASGNEVPRGECSGPA

NCOR2

726

Q9Y618
NDTARCPGGGPAVVS

LOXL3

266

P58215
GLEGADIPAFGPCSR

LRRN4CL

171

Q8ND94
PGRCAPSAGSPAAAV

MEPCE

51

Q7L2J0
SSPAGGCREVPQAAS

FAM90A1

231

Q86YD7
CTPREPGVAGGDVCS

MEIS2

101

O14770
GGAGPCATVSVFPGA

CARM1

21

Q86X55
ASAEGREPSPQCGGS

NHSL1

1591

Q5SYE7
RAAAAAGAPPGALGC

GPR27

81

Q9NS67
GPSVAAAAPRQDCTG

FBLN2

21

P98095
GPRVGGVAAAATEAP

PDZD4

606

Q76G19
PGSGEDCGSVSVAFP

PTGER3

41

P43115
QGSVRGCPALEGSVG

RASGRP4

231

Q8TDF6
GVAGPAAHPGVSDRC

GXYLT1

61

Q4G148
ACKAEPRPVAASGGG

HNRNPUL2

56

Q1KMD3
AGPACPEGGRAETQA

COG8

591

Q96MW5
GPGLVCASQAAGAAP

IGFBPL1

86

Q8WX77
GCTPSGEGADSEPRA

GPKOW

136

Q92917
SPRPGTAACGASDAP

GGA3

431

Q9NZ52
PEQGCPVGSDSTGLA

GLI1

816

P08151
AVLPGTCGGGPRAAF

TUBGCP6

481

Q96RT7
CPSADPTVKLGAVGG

ELP1

456

O95163
SSCEGAAGTPRPAGE

DDX11

96

Q96FC9
EQSGSPCRAAGVSPG

INSM2

71

Q96T92
GKAPTDCASGPAAAG

INSM2

201

Q96T92
AAAAPDTCGHIGRGP

PKD1L2

121

Q7Z442
GPGAPAAAGAEACRR

GPR149

276

Q86SP6
SRAASVGRCSVPEGP

PCDHB4

716

Q9Y5E5
GGVSAGVAVLGACPS

MYO15B

56

Q96JP2
VGGPCADSASGVGEP

GYG2

316

O15488
GVGEPCENSTPSAGV

GYG2

326

O15488
EGRPAPGGTAASVAA

NKX3-2

31

P78367
PGGTAASVAAAPAVC

NKX3-2

36

P78367
PGAQVCAAAPAIGTG

PAX1

471

P15863
RAVCASIPGGPSPGA

DAAM1

521

Q9Y4D1
TEQPCAAAAGPGGRR

FZD9

481

O00144
RGGCIALAAPGTPAA

CABLES1

116

Q8TDN4
VGVVVPCPAAGSPSA

DSCAML1

41

Q8TD84
GGPDACGVISATDGP

FCGBP

2261

Q9Y6R7
GAGAPGADACSVPVS

CERK

41

Q8TCT0
SSCEGAAGTPRPAGE

DDX11L8

96

A8MPP1
SCEGAAGTPRPAGEP

DDX12P

116

Q92771
ASGVEPGRCSGSEPS

MCRS1

76

Q96EZ8
PGVLGAAGEPCAKTT

INSRR

181

P14616
PGPDSFRGAVVCGDL

DNAH9

111

Q9NYC9
SGGDTAPALPGRTVC

FARP2

856

O94887
RCEAAPATPGVPAGG

HOXA4

156

Q00056
GGVGADPAEALRPAC

NLGN2

751

Q8NFZ4
SCADPTGCGTGPDAR

DPP7

331

Q9UHL4
SCGGPADLGQSGEVP

KIFC2

101

Q96AC6
AAELCGRPGPGATSA

LRP8

241

Q14114
GRPGPGATSAPAACA

LRP8

246

Q14114
EDSTFPACSVGGIPG

MTBP

61

Q96DY7
EAATCAGPGSLAGQP

PKD1

151

P98161
PSAGPLVVHCSAGAG

PTPRM

1086

P28827
HVCSRGPVGGSDAAP

PANK1

181

Q8TE04
ASVGRCSVPEGPFPG

PCDHB8

721

Q9UN66
RVTDVPCASPGSVAG

NYX

356

Q9GZU5
LPCAEARGPGTSAGS

TRMT44

51

Q8IYL2
RAGTAPPAAFGGAEC

SSPOP

3011

A2VEC9
PLCASPGAAVGASRS

SPATA5L1

76

Q9BVQ7
GLACAPGGPEAATGA

SIM2

621

Q14190
VRGFSCPRPGGEAAA

SHISAL2A

16

Q6UWV7
SLSPGGERACEGVPS

SETD5

1041

Q9C0A6
GAEGCSAGAQEPPRA

SHROOM2

541

Q13796
PAAPGTTAPEGGDRC

SHISA8

46

B8ZZ34
PCAGQDEAAAPGGSV

RFXAP

51

O00287
GDVASFRCSPGPLEG

NPAP1

196

Q9NZP6
AAVTGAGAGEPSRPV

ROBO4

421

Q8WZ75
GSCPVDGDGPVTTAV

SH3RF1

771

Q7Z6J0
CALGRAEAAGLGPSP

ALKAL2

66

Q6UX46
GETARAAGGSPAVGC

CAMKMT

11

Q7Z624
GVAGPRGQDPVSSPC

CLCC1

536

Q96S66
PEGAGCREEAASPAG

CNNM3

81

Q8NE01
PGTLTCPERTGGDAA

nan

41

P0C880
AGLCGAGSEPSIAPT

RSPH3

71

Q86UC2
GLCGVAAAATGHTPP

WWC2

521

Q6AWC2
NGTRGDCGSPAVGII

SCN10A

1686

Q9Y5Y9
PSDLVGVFSCVGGAG

TIE1

96

P35590
GEALSFGASPGRCPA

TNKS1BP1

1431

Q9C0C2
PGTGPSGTCEAPVAV

TBC1D10B

216

Q4KMP7
GACGDGQSSRVSPPA

TACC2

951

O95359
PPSTVASGAGRCESG

STIMATE

16

Q86TL2
PGAVGAGEFVSPCES

TP53BP1

1691

Q12888
LRCVPAPGAGASGGT

TBC1D4

91

O60343
GPARGPCTAAGRSAS

nan

6

Q96MT0
PGDVTAGVSRAAGSP

UNQ6494/PRO21346

46

Q6UXR6
GVSGRPVCGVAGIPS

ZCCHC14

226

Q8WYQ9
AGEQAPGTAPCSRGS

TNFRSF12A

26

Q9NP84
GAPQCSVEGGPGDRS

VSIG10L

496

Q86VR7
CGATARTLPEGSAVP

TRANK1

646

O15050
ARPSRAPVSICGGGE

PJA1

231

Q8NG27
SAGRIPPCFLVGEGA

TASP1

156

Q9H6P5
CFPSGPELRGAGIAA

WDR36

41

Q8NI36
PRALPAAAATAGCAG

LIME1

126

Q9H400
VKAAIGGGVSPDVCP

MYOM1

831

P52179