Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR5B3 OR5T3 NPR3 NPY1R NPY6R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 GRPR S1PR3 OR4K14 OR4D2 OR2T3 OR10G6 ADORA3 OR4S1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	8.13e-20	884	104	33	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR5B3 OR5T3 NPR3 NPY1R NPY6R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 TLR6 GRPR S1PR3 OR4K14 OR4D2 OR2T3 OR10G6 ADORA3 OR4S1 TLR1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	4.77e-16	1353	104	35	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	5.00e-16	431	104	22	GO:0004984
GeneOntologyMolecularFunction	Gq/11-coupled serotonin receptor activity	HTR2A HTR2B HTR2C	1.37e-07	3	104	3	GO:0001587
GeneOntologyMolecularFunction	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	HTR2A HTR2C	2.69e-05	2	104	2	GO:0071886
GeneOntologyMolecularFunction	serotonin binding	HTR2A HTR2B HTR2C	3.78e-05	13	104	3	GO:0051378
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR6 TLR1	1.60e-04	4	104	2	GO:0035663
GeneOntologyMolecularFunction	amine binding	HTR2A HTR2B HTR2C	1.70e-04	21	104	3	GO:0043176
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	HTR2A HTR2B HTR2C	1.97e-04	22	104	3	GO:0004993
GeneOntologyMolecularFunction	peptide YY receptor activity	NPY1R NPY6R	2.66e-04	5	104	2	GO:0001601
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPR3 NPY1R NPY6R MAS1L GRPR	6.60e-04	133	104	5	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPR3 NPY1R NPY6R MAS1L GRPR	8.32e-04	140	104	5	GO:0001653
GeneOntologyMolecularFunction	neuropeptide binding	NPY1R NPY6R GRPR	9.38e-04	37	104	3	GO:0042923
GeneOntologyMolecularFunction	lipopeptide binding	TLR6 TLR1	1.18e-03	10	104	2	GO:0071723
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	HTR2A HTR2B HTR2C	1.27e-03	41	104	3	GO:0008227
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY1R NPY6R	1.43e-03	11	104	2	GO:0004983
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN3A	2.35e-03	14	104	2	GO:0031402
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR5B3 OR5T3 HTR2A OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 WDR47 OR2T3 OR10G6 OR4S1 SCN1A OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.02e-16	582	104	25	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 TLR6 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 TLR1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.09e-16	524	104	24	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus	OR5B3 OR5T3 HTR2A OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 TLR6 OR4K14 OR4D2 WDR47 OR2T3 OR10G6 OR4S1 SCN1A TLR1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.56e-16	722	104	27	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	2.71e-16	432	104	22	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.25e-15	465	104	22	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	2.99e-15	485	104	22	GO:0050907
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR5B3 OR5T3 NPR3 NPY1R NPY6R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 GRPR S1PR3 OR4K14 OR4D2 OR2T3 OR10G6 ADORA3 OR4S1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	2.19e-14	1395	104	33	GO:0007186
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	3.50e-14	547	104	22	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	OR5B3 OR5T3 NPY1R HTR2A OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 WDR47 OR2T3 OR10G6 OR4S1 SCN1A OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.38e-11	1072	104	26	GO:0007600
GeneOntologyBiologicalProcess	phospholipase C-activating serotonin receptor signaling pathway	HTR2A HTR2B HTR2C	1.25e-07	3	104	3	GO:0007208
GeneOntologyBiologicalProcess	positive regulation of phosphatidylinositol biosynthetic process	HTR2A HTR2B HTR2C	1.25e-07	3	104	3	GO:0010513
GeneOntologyBiologicalProcess	regulation of phosphatidylinositol biosynthetic process	HTR2A HTR2B HTR2C	1.24e-06	5	104	3	GO:0010511
GeneOntologyBiologicalProcess	serotonin receptor signaling pathway	HTR2A HTR2B HTR2C	2.00e-05	11	104	3	GO:0007210
GeneOntologyBiologicalProcess	positive regulation of phospholipid biosynthetic process	HTR2A HTR2B HTR2C	2.65e-05	12	104	3	GO:0071073
GeneOntologyBiologicalProcess	regulation of phospholipid metabolic process	ABCA3 HTR2A HTR2B HTR2C	4.85e-05	40	104	4	GO:1903725
GeneOntologyBiologicalProcess	positive regulation of phospholipid metabolic process	HTR2A HTR2B HTR2C	6.65e-05	16	104	3	GO:1903727
GeneOntologyBiologicalProcess	detection of bacterial lipopeptide	TLR6 TLR1	7.53e-05	3	104	2	GO:0070340
GeneOntologyBiologicalProcess	detection of bacterial lipoprotein	TLR6 TLR1	1.50e-04	4	104	2	GO:0042494
GeneOntologyBiologicalProcess	regulation of phospholipid biosynthetic process	HTR2A HTR2B HTR2C	1.55e-04	21	104	3	GO:0071071
GeneOntologyBiologicalProcess	G protein-coupled serotonin receptor signaling pathway	HTR2A HTR2B HTR2C	2.05e-04	23	104	3	GO:0098664
GeneOntologyBiologicalProcess	sensitization	HTR2A HTR2C	2.49e-04	5	104	2	GO:0046960
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	NPY1R HTR2A HTR2B HTR2C	2.55e-04	61	104	4	GO:0007187
GeneOntologyBiologicalProcess	neuronal stem cell population maintenance	WDR47 FANCD2 PCM1	2.98e-04	26	104	3	GO:0097150
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	NPR3 HTR2A HTR2B HTR2C GRPR	5.70e-04	133	104	5	GO:0007200
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	HTR2A HTR2B HTR2C GPR39 SLC26A9 RYR3 SCN1A SCN3A ORAI3 KCNS1 KCNS3 NIPA2 SLC4A4 WNK3	5.81e-04	1017	104	14	GO:0098660
GeneOntologyCellularComponent	G protein-coupled serotonin receptor complex	HTR2A HTR2B HTR2C	4.63e-07	4	103	3	GO:0098666
Domain	7tm_1	OR5B3 OR5T3 NPY1R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 GRPR S1PR3 OR4K14 OR4D2 OR2T3 OR10G6 ADORA3 OR4S1 OR10W1 OR4C12 OR6C6 OR1L4 OR2AG1	1.37e-18	677	101	29	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR5B3 OR5T3 NPY1R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 GRPR S1PR3 OR4K14 OR4D2 OR2T3 OR10G6 ADORA3 OR4S1 OR10W1 OR4C12 OR6C6 OR1L4 OR2AG1	1.88e-18	685	101	29	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5B3 OR5T3 NPY1R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 GRPR S1PR3 OR4K14 OR4D2 OR2T3 OR10G6 ADORA3 OR4S1 OR10W1 OR4C12 OR6C6 OR1L4 OR2AG1	2.38e-18	691	101	29	PS50262
Domain	GPCR_Rhodpsn	OR5B3 OR5T3 NPY1R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 GRPR S1PR3 OR4K14 OR4D2 OR2T3 OR10G6 ADORA3 OR4S1 OR10W1 OR4C12 OR6C6 OR1L4 OR2AG1	2.47e-18	692	101	29	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR5B3 OR5T3 NPY1R HTR2A HTR2B HTR2C MAS1L OR4N5 GPR39 OR4D1 OR2AG2 OR2J3 OR4D6 OR14C36 OR2T34 GRPR S1PR3 OR4K14 OR4D2 OR2T3 ADORA3 OR4S1 OR10W1 OR4C12 OR6C6 OR1L4 OR2AG1	1.22e-16	670	101	27	IPR017452
Domain	Olfact_rcpt	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 OR10W1 OR4C12 OR6C6 OR1L4 OR2AG1	2.52e-14	393	101	20	IPR000725
Domain	ARM-type_fold	DOCK2 TTI2 MROH5 VIRMA RYR3 PPP2R1A AP1G1 NBEAL2 RRP12 LTN1 UTP20 NUP188 GCN1	3.58e-08	339	101	13	IPR016024
Domain	7TM_GPCR_Srsx	HTR2A HTR2B HTR2C OR2T34 GRPR S1PR3 OR2T3 ADORA3	1.65e-07	112	101	8	SM01381
Domain	ARM-like	DOCK2 TTI2 MROH5 PPP2R1A AP1G1 NBEAL2 RRP12 LTN1 UTP20 GCN1	2.04e-06	270	101	10	IPR011989
Domain	5HT_rcpt	HTR2A HTR2B HTR2C	1.26e-05	9	101	3	IPR002231
Domain	Channel_four-helix_dom	SCN1A SCN3A KCNS1 KCNS3	2.55e-04	57	101	4	IPR027359
Domain	-	SCN1A SCN3A KCNS1 KCNS3	2.55e-04	57	101	4	1.20.120.350
Domain	Toll-like_receptor	TLR6 TLR1	2.86e-04	5	101	2	IPR017241
Domain	Ion_trans_dom	RYR3 SCN1A SCN3A KCNS1 KCNS3	3.86e-04	114	101	5	IPR005821
Domain	Ion_trans	RYR3 SCN1A SCN3A KCNS1 KCNS3	3.86e-04	114	101	5	PF00520
Domain	Na_trans_cytopl	SCN1A SCN3A	4.28e-04	6	101	2	PF11933
Domain	Na_trans_cytopl	SCN1A SCN3A	4.28e-04	6	101	2	IPR024583
Domain	K_chnl_volt-dep_Kv9	KCNS1 KCNS3	5.97e-04	7	101	2	IPR003971
Domain	APC_su10/DOC_dom	MYCBP2 ZZEF1	5.97e-04	7	101	2	IPR004939
Domain	DOC	MYCBP2 ZZEF1	5.97e-04	7	101	2	PS51284
Domain	APC10	MYCBP2 ZZEF1	5.97e-04	7	101	2	SM01337
Domain	ANAPC10	MYCBP2 ZZEF1	5.97e-04	7	101	2	PF03256
Domain	PH_dom-spectrin-type	PSD2 PSD4	1.02e-03	9	101	2	IPR001605
Domain	Na_channel_asu	SCN1A SCN3A	1.27e-03	10	101	2	IPR001696
Domain	Na_trans_assoc	SCN1A SCN3A	1.27e-03	10	101	2	IPR010526
Domain	Na_trans_assoc	SCN1A SCN3A	1.27e-03	10	101	2	PF06512
Domain	-	MROH5 PPP2R1A AP1G1 RRP12 UTP20 GCN1	1.31e-03	222	101	6	1.25.10.10
Domain	HEAT	PPP2R1A UTP20 GCN1	2.23e-03	48	101	3	PF02985
Domain	zf-RING_2	MYCBP2 LTN1 RNF182	2.80e-03	52	101	3	PF13639
Domain	-	PSD2 PSD4	2.90e-03	15	101	2	1.10.1000.11
Domain	Sec7	PSD2 PSD4	2.90e-03	15	101	2	PF01369
Domain	Sec7_alpha_orthog	PSD2 PSD4	2.90e-03	15	101	2	IPR023394
Domain	Sec7	PSD2 PSD4	3.31e-03	16	101	2	SM00222
Domain	SEC7	PSD2 PSD4	3.31e-03	16	101	2	PS50190
Domain	Sec7_dom	PSD2 PSD4	3.31e-03	16	101	2	IPR000904
Domain	HEAT_type_2	PPP2R1A GCN1	3.73e-03	17	101	2	IPR021133
Domain	HEAT	PPP2R1A UTP20 GCN1	3.82e-03	58	101	3	IPR000357
Domain	TIR	TLR6 TLR1	5.69e-03	21	101	2	SM00255
Domain	TIR	TLR6 TLR1	6.23e-03	22	101	2	PF01582
Domain	HEAT_REPEAT	PPP2R1A UTP20 GCN1	6.46e-03	70	101	3	PS50077
Domain	-	TLR6 TLR1	6.80e-03	23	101	2	3.40.50.10140
Domain	TIR	TLR6 TLR1	7.40e-03	24	101	2	PS50104
Domain	TIR_dom	TLR6 TLR1	8.01e-03	25	101	2	IPR000157
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 OR10W1 OR4C12 OR6C6 OR51H1 OR1L4 OR2AG1	3.16e-13	417	84	20	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR10G6 OR4S1 HSD17B6 SCN3A OR10W1 OR4C12 OR6C6 OR51H1 OR1L4 OR2AG1	1.17e-11	636	84	22	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR2T3 OR4S1 OR4C12 OR6C6 OR1L4 OR2AG1	1.04e-10	389	84	17	M14091
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPY1R NPY6R HTR2A HTR2B HTR2C MAS1L GPR39 OR2J3 GRPR ADORA3 OR2AG1	3.85e-07	260	84	11	M39397
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPY1R NPY6R HTR2B HTR2C OR2AG2 GRPR ADORA3 OR7A2P OR2AG1	1.57e-06	186	84	9	MM15994
Pathway	REACTOME_SEROTONIN_RECEPTORS	HTR2A HTR2B HTR2C	3.25e-05	11	84	3	MM15008
Pathway	REACTOME_SEROTONIN_RECEPTORS	HTR2A HTR2B HTR2C	4.32e-05	12	84	3	M6034
Pathway	WP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING	HTR2A HTR2B HTR2C	2.16e-04	20	84	3	M39485
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	HTR2A HTR2B HTR2C GRPR	2.19e-04	50	84	4	M47951
Pathway	WP_GPCRS_OTHER	GPR39 OR2AG2 OR1F2P ADORA3 OR7A2P	2.66e-04	96	84	5	MM15939
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPY1R HTR2A HTR2B HTR2C GPR39 GRPR S1PR3 ADORA3	7.70e-04	330	84	8	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPY1R HTR2A HTR2B HTR2C GPR39 GRPR S1PR3 ADORA3	8.17e-04	333	84	8	MM14963
Pathway	WP_MONOAMINE_GPCRS	HTR2A HTR2B HTR2C	9.79e-04	33	84	3	M39585
Pathway	WP_GPCRS_NONODORANT	NPY1R NPY6R HTR2B HTR2C GRPR S1PR3 ADORA3	1.03e-03	266	84	7	MM15843
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR4D2 OR10G6 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.57e-17	340	105	18	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR4D2 OR10G6 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.57e-17	340	105	18	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR4D2 OR10G6 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	1.84e-17	343	105	18	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR4D2 OR10G6 OR10W1 OR4C12 OR6C6 OR7A2P OR51H1 OR1L4 OR2AG1	2.14e-17	346	105	18	14611657
Pubmed	The human olfactory receptor gene family.	OR5B3 OR5T3 OR4N5 OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR14C36 OR2T34 OR4K14 OR4D2 OR10G6 OR4S1 OR10W1 OR4C12 OR7A2P OR51H1 OR1L4 OR2AG1	2.25e-16	541	105	20	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR4D1 OR2AG2 OR1F2P OR2J3 OR4D6 OR2T34 OR4K14 OR4D2 OR4C12 OR7A2P OR1L4 OR2AG1	3.35e-12	219	105	12	12213199
Pubmed	Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	28258217
Pubmed	Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	19057895
Pubmed	Serotonin and the 5-HT(2B) receptor in the development of enteric neurons.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	10627607
Pubmed	Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	18703043
Pubmed	Expression of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors in the mouse embryo.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	10978843
Pubmed	Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	15831837
Pubmed	The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	7582481
Pubmed	5-HT2 receptors facilitate JC polyomavirus entry.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	24089568
Pubmed	Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes.	HTR2A HTR2B HTR2C	2.67e-08	3	105	3	1381232
Pubmed	Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.	HTR2A HTR2B HTR2C	1.07e-07	4	105	3	11150294
Pubmed	5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells.	HTR2A HTR2B HTR2C	2.66e-07	5	105	3	9165122
Pubmed	An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors.	HTR2A HTR2B HTR2C	2.66e-07	5	105	3	8833759
Pubmed	Toll-like receptors 2 and 4 modulate the contractile response induced by serotonin in mouse ileum: analysis of the serotonin receptors involved.	HTR2A HTR2B HTR2C	2.22e-06	9	105	3	26053401
Pubmed	Multiplicity of mechanisms of serotonin receptor signal transduction.	HTR2A HTR2B HTR2C	5.77e-06	12	105	3	11916537
Pubmed	Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.	HTR2A HTR2B HTR2C	7.48e-06	13	105	3	22569571
Pubmed	Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning.	HTR2A HTR2B HTR2C	7.48e-06	13	105	3	22640814
Pubmed	Genetic evaluation of the serotonergic system in chronic fatigue syndrome.	HTR2A HTR2B HTR2C	7.48e-06	13	105	3	18079067
Pubmed	Depression in Alzheimer's disease: the effect of serotonin receptor gene variation.	HTR2A HTR2C	9.03e-06	2	105	2	12707936
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR6 TLR1	9.03e-06	2	105	2	22315281
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR6 TLR1	9.03e-06	2	105	2	18036178
Pubmed	Unified approach to the analysis of genetic variation in serotonergic pathways.	HTR2A HTR2C	9.03e-06	2	105	2	10581480
Pubmed	5HT2A and 5HT2C receptor polymorphisms and predicting clinical response to olanzapine in schizophrenia.	HTR2A HTR2C	9.03e-06	2	105	2	12454564
Pubmed	Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors.	HTR2A HTR2B	9.03e-06	2	105	2	24244317
Pubmed	Regulation of serotonin-2C receptor G-protein coupling by RNA editing.	HTR2A HTR2C	9.03e-06	2	105	2	9153397
Pubmed	Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line.	HTR2A HTR2B	9.03e-06	2	105	2	16517693
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR6 TLR1	9.03e-06	2	105	2	24445834
Pubmed	5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.	HTR2A HTR2B	9.03e-06	2	105	2	23346101
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR6 TLR1	9.03e-06	2	105	2	26470427
Pubmed	Contribution of 5-HT2A receptor gene -1438A>G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents.	HTR2A HTR2C	9.03e-06	2	105	2	16741915
Pubmed	Association of 5-HTR2A and 5-HTR2C serotonin receptor gene polymorphisms with depression risk in patients with coronary heart disease.	HTR2A HTR2C	9.03e-06	2	105	2	24770757
Pubmed	Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice.	HTR2A HTR2C	9.03e-06	2	105	2	21340474
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR6 TLR1	9.03e-06	2	105	2	21852947
Pubmed	Association studies of 5-HT2A and 5-HT2C serotonin receptor gene polymorphisms with prophylactic lithium response in bipolar patients.	HTR2A HTR2C	9.03e-06	2	105	2	16382194
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR6 TLR1	9.03e-06	2	105	2	24984237
Pubmed	Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.	HTR2A HTR2C	9.03e-06	2	105	2	1722404
Pubmed	Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog.	HTR2A HTR2B	9.03e-06	2	105	2	15862800
Pubmed	Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.	HTR2A HTR2B	9.03e-06	2	105	2	21789169
Pubmed	Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice.	HTR2A HTR2B	9.03e-06	2	105	2	31787571
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	9.03e-06	2	105	2	24990319
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR6 TLR1	9.03e-06	2	105	2	11123271
Pubmed	SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.	TLR6 TLR1	9.03e-06	2	105	2	25261617
Pubmed	Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors.	HTR2A HTR2C	9.03e-06	2	105	2	17625040
Pubmed	Mammalian SNM1 is required for genome stability.	FANCD2 DCLRE1A	9.03e-06	2	105	2	18180189
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR6 TLR1	9.03e-06	2	105	2	29175392
Pubmed	Role of 5HT 2A and 5HT 2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease.	HTR2A HTR2C	9.03e-06	2	105	2	17098333
Pubmed	Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors.	HTR2A HTR2C	9.03e-06	2	105	2	22397586
Pubmed	[The association between polymorphism of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome in Han population].	HTR2A HTR2C	9.03e-06	2	105	2	18336767
Pubmed	5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'.	HTR2B HTR2C	9.03e-06	2	105	2	20846463
Pubmed	New mouse 5-HT2-like receptor. Expression in brain, heart and intestine.	HTR2B HTR2C	9.03e-06	2	105	2	1426253
Pubmed	Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.	HTR2A HTR2C	9.03e-06	2	105	2	23537943
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR6 TLR1	9.03e-06	2	105	2	28474755
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	9.03e-06	2	105	2	27690330
Pubmed	Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine.	HTR2A HTR2C	9.03e-06	2	105	2	19142110
Pubmed	5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice.	HTR2A HTR2C	9.03e-06	2	105	2	19322172
Pubmed	Serotonin-2A and 2C receptor gene polymorphisms in Japanese patients with obstructive sleep apnea.	HTR2A HTR2C	9.03e-06	2	105	2	16258205
Pubmed	Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.	HTR2B HTR2C	9.03e-06	2	105	2	12970106
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	9.03e-06	2	105	2	23965409
Pubmed	Association of Serotonin Receptor Gene Polymorphisms with Regulatory and Adaptive Capacities of Medical Students.	HTR2A HTR2C	9.03e-06	2	105	2	37768455
Pubmed	5-HT(2A) and 5-HT(2C) receptor stimulation are differentially involved in the cortical dopamine efflux-Studied in 5-HT(2A) and 5-HT(2C) genetic mutant mice.	HTR2A HTR2C	9.03e-06	2	105	2	21118683
Pubmed	A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.	TLR6 TLR1	9.03e-06	2	105	2	22778390
Pubmed	5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female.	HTR2A HTR2C	9.03e-06	2	105	2	12097814
Pubmed	Chronic lithium administration to rats selectively modifies 5-HT2A/2C receptor-mediated brain signaling via arachidonic acid.	HTR2A HTR2C	9.03e-06	2	105	2	15562295
Pubmed	Sound-induced seizures in serotonin 5-HT2c receptor mutant mice.	HTR2A HTR2C	9.03e-06	2	105	2	9241279
Pubmed	Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion.	HTR2A HTR2C	9.03e-06	2	105	2	8626761
Pubmed	Mast cells as sensors of cell injury through IL-33 recognition.	TLR6 ADORA3 TLR1	9.50e-06	14	105	3	21239713
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	TTI2 PPP2R1A AP1G1 NBEAL2 LTN1 GCN1	2.04e-05	183	105	6	23956138
Pubmed	Association study of the serotoninergic system in migraine in the Spanish population.	HTR2A HTR2B HTR2C	2.11e-05	18	105	3	19455600
Pubmed	Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene.	HTR2A HTR2C	2.70e-05	3	105	2	12759158
Pubmed	Polymorphisms of the 5-hydroxytryptamine 2A/2C receptor genes and 5-hydroxytryptamine transporter gene in Chinese patients with OSAHS.	HTR2A HTR2C	2.70e-05	3	105	2	23494654
Pubmed	Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.	TLR6 TLR1	2.70e-05	3	105	2	16081826
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN3A	2.70e-05	3	105	2	12610651
Pubmed	Electrically silent potassium channel subunits from human lens epithelium.	KCNS1 KCNS3	2.70e-05	3	105	2	10484328
Pubmed	Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptors via ERK1/2 signalling pathways.	NPY1R HTR2B	2.70e-05	3	105	2	19614678
Pubmed	Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia.	HTR2A HTR2C	2.70e-05	3	105	2	19439249
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR6 TLR1	2.70e-05	3	105	2	18752252
Pubmed	Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.	HTR2A HTR2C	2.70e-05	3	105	2	15313842
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A	2.70e-05	3	105	2	33895391
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR6 TLR1	2.70e-05	3	105	2	25028161
Pubmed	Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.	TLR6 TLR1	2.70e-05	3	105	2	15731092
Pubmed	Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.	TLR6 TLR1	2.70e-05	3	105	2	25246533
Pubmed	The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.	TLR6 TLR1	2.70e-05	3	105	2	11095740
Pubmed	Serotonergic pathway genes and subtypes of alcoholism: association studies.	HTR2A HTR2C	2.70e-05	3	105	2	11525423
Pubmed	Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor.	NPY1R NPY6R	2.70e-05	3	105	2	9315606
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN3A	2.70e-05	3	105	2	23859570
Pubmed	Seasonal affective disorder and serotonin-related polymorphisms.	HTR2A HTR2C	2.70e-05	3	105	2	11300730
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR6 TLR1	2.70e-05	3	105	2	11607792
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR6 TLR1	2.70e-05	3	105	2	25850295
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN3A	2.70e-05	3	105	2	18784617
Pubmed	Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.	TLR6 TLR1	2.70e-05	3	105	2	18451040
Pubmed	TLR1- and TLR6-independent recognition of bacterial lipopeptides.	TLR6 TLR1	2.70e-05	3	105	2	16455646
Pubmed	Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.	TLR6 TLR1	2.70e-05	3	105	2	24922103
Pubmed	Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.	TLR6 TLR1	2.70e-05	3	105	2	24683188
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN3A	2.70e-05	3	105	2	17544618
Pubmed	A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.	TLR6 TLR1	2.70e-05	3	105	2	16177110
Cytoband	4p14	TLR6 TLR1 DTHD1 PGM2	2.70e-06	42	105	4	4p14
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	TLR6 TLR1 DTHD1 PGM2	1.77e-05	67	105	4	chr4p14
Cytoband	11q12.1	OR5B3 OR5T3 OR4D6 OR10W1	5.29e-04	161	105	4	11q12.1
Cytoband	5q31.2	PSD2 NPY6R	1.88e-03	28	105	2	5q31.2
Cytoband	1q44	OR14C36 OR2T34 OR2T3	2.10e-03	110	105	3	1q44
GeneFamily	Olfactory receptors, family 4	OR4N5 OR4D1 OR4D6 OR4K14 OR4D2 OR4S1 OR4C12	1.39e-06	129	78	7	151
GeneFamily	5-hydroxytryptamine receptors, G protein-coupled	HTR2A HTR2B HTR2C	2.14e-05	13	78	3	170
GeneFamily	Olfactory receptors, family 2	OR2AG2 OR2J3 OR2T34 OR2T3 OR2AG1	1.28e-04	113	78	5	149
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN3A	6.49e-04	9	78	2	1203
GeneFamily	Neuropeptide receptors	NPY1R NPY6R	8.09e-04	10	78	2	854
GeneFamily	CD molecules\|Toll like receptors	TLR6 TLR1	8.09e-04	10	78	2	948
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANKRD31 PSD2 RYR3 HSD17B6 SLC4A4 SLC2A12 RNF182	4.56e-07	200	104	7	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GPR39 ZSWIM6 NBEAL2 SCN3A PKHD1 AFDN	5.81e-06	191	104	6	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
Computational	Genes in the cancer module 146.	NPR3 NPY1R HTR2B HTR2C GPR39 GRPR	4.34e-06	102	46	6	MODULE_146
Drug	Me-M	HTR2A HTR2B HTR2C	9.26e-08	3	104	3	CID000077590
Drug	Norfenfluramine	HTR2A HTR2B HTR2C	9.26e-08	3	104	3	ctd:D009642
Drug	(ch3)2cnh2	HTR2A HTR2B HTR2C	3.69e-07	4	104	3	CID000520257
Drug	PIM-35	HTR2A HTR2B HTR2C	3.69e-07	4	104	3	CID000195658
Drug	2-aminopropane hydrochloride	HTR2A HTR2B HTR2C	3.69e-07	4	104	3	CID000027399
Drug	Tegaserod	HTR2A HTR2B HTR2C	3.69e-07	4	104	3	DB01079
Drug	butyranilide	HTR2A HTR2B HTR2C	9.20e-07	5	104	3	CID000014323
Drug	Methysergide	HTR2A HTR2B HTR2C	9.20e-07	5	104	3	DB00247
Drug	SB221284	HTR2A HTR2B HTR2C	9.20e-07	5	104	3	CID000443389
Drug	Clomipramine	HTR2A HTR2B HTR2C	1.83e-06	6	104	3	DB01242
Drug	Dmipap	HTR2A HTR2B HTR2C	1.83e-06	6	104	3	CID000126620
Drug	Sch-38548	HTR2A HTR2B HTR2C	1.83e-06	6	104	3	CID000130519
Drug	BrAcTFMPP	HTR2A HTR2B HTR2C	1.83e-06	6	104	3	CID000146887
Drug	LY215840	HTR2A HTR2B HTR2C	3.20e-06	7	104	3	CID000132049
Drug	3,4-Methylenedioxymethamphetamine	HTR2A HTR2B HTR2C	3.20e-06	7	104	3	DB01454
Drug	Fenfluramine	HTR2A HTR2B HTR2C	3.20e-06	7	104	3	ctd:D005277
Drug	SB 206553	HTR2A HTR2B HTR2C	3.20e-06	7	104	3	ctd:C094868
Drug	oracaine	HTR2A HTR2B HTR2C	3.20e-06	7	104	3	CID000004065
Drug	urea HCl	HTR2A HTR2B HTR2C	3.20e-06	7	104	3	CID000101721
Drug	dibenzosuberane	HTR2A HTR2B HTR2C	3.20e-06	7	104	3	CID000070029
Drug	minaprine	HTR2A HTR2B HTR2C FRMD7 FANCD2	4.78e-06	54	104	5	CID000004199
Drug	medifoxamine	HTR2A HTR2B HTR2C	5.10e-06	8	104	3	CID000036109
Drug	SB 216641	HTR2A HTR2B HTR2C	5.10e-06	8	104	3	CID003292447
Drug	amesergide	HTR2A HTR2B HTR2C	5.10e-06	8	104	3	CID000060740
Drug	bufotenine	NPR3 HTR2A HTR2B HTR2C	6.65e-06	27	104	4	CID000010257
Drug	NIASP	HTR2A HTR2B HTR2C	7.62e-06	9	104	3	CID006439184
Drug	Minaprine	HTR2A HTR2B HTR2C	7.62e-06	9	104	3	DB00805
Drug	iodoLSD	HTR2A HTR2B HTR2C	7.62e-06	9	104	3	CID000151142
Drug	Ritanserin	HTR2A HTR2B HTR2C	1.09e-05	10	104	3	ctd:D016713
Drug	seganserin	HTR2A HTR2B HTR2C	1.09e-05	10	104	3	CID000071767
Drug	LY344864	HTR2A HTR2B HTR2C	1.09e-05	10	104	3	CID005311097
Drug	M-HN	HTR2A HTR2B HTR2C RYR3	1.18e-05	31	104	4	CID000015450
Drug	RS-127445	HTR2A HTR2B HTR2C	1.49e-05	11	104	3	CID000196968
Drug	homophthalimide	HTR2A HTR2B HTR2C	1.49e-05	11	104	3	CID000349435
Drug	CGS 12066B	NPR3 HTR2A HTR2B HTR2C	1.71e-05	34	104	4	CID000002689
Drug	BRL15572	HTR2A HTR2B HTR2C	1.98e-05	12	104	3	CID003654103
Drug	Chlorprothixene	HTR2A HTR2B HTR2C	1.98e-05	12	104	3	DB01239
Drug	sergolexole	HTR2A HTR2B HTR2C	1.98e-05	12	104	3	CID000060262
Drug	Ro 60-0175	HTR2B HTR2C	2.07e-05	2	104	2	ctd:C103848
Drug	AC1Q1YRG	HTR2B HTR2C	2.07e-05	2	104	2	CID000105432
Drug	SB 228357	HTR2B HTR2C	2.07e-05	2	104	2	ctd:C118947
Drug	SB-228357	HTR2B HTR2C	2.07e-05	2	104	2	CID000443390
Drug	Lisuride	HTR2A HTR2B HTR2C	3.25e-05	14	104	3	DB00589
Drug	Pramipexole	HTR2A HTR2B HTR2C	3.25e-05	14	104	3	DB00413
Drug	compound 4d	HTR2A HTR2B HTR2C	3.25e-05	14	104	3	CID000448577
Drug	Ropinirole	HTR2A HTR2B HTR2C	3.25e-05	14	104	3	DB00268
Drug	L-694,247	HTR2A HTR2B HTR2C	3.25e-05	14	104	3	CID000132059
Drug	YM348	HTR2A HTR2B HTR2C	3.25e-05	14	104	3	CID003045225
Drug	haloperidol; Down 200; 10uM; MCF7; HG-U133A	SERHL2 NMNAT2 NPR3 ZZEF1 RRP12 SLC4A4 DOP1A	3.30e-05	196	104	7	492_DN
Drug	Dapsone [80-08-0]; Up 200; 16.2uM; PC3; HT_HG-U133A	HTR2B TLR6 PDE4DIP KCNS1 COL14A1 AFDN PSD4	3.64e-05	199	104	7	5078_UP
Drug	Cabergoline	HTR2A HTR2B HTR2C	4.05e-05	15	104	3	DB00248
Drug	Apomorphine	HTR2A HTR2B HTR2C	4.05e-05	15	104	3	DB00714
Drug	dotarizine	HTR2A HTR2B HTR2C	4.05e-05	15	104	3	CID000055285
Drug	ondansetron	HTR2A HTR2B HTR2C OR2AG1	4.85e-05	44	104	4	CID000004595
Drug	1-(3-chlorophenyl)piperazine	HTR2A HTR2B HTR2C	4.97e-05	16	104	3	ctd:C015068
Drug	isamoltane	NPR3 HTR2B HTR2C	4.97e-05	16	104	3	CID000127403
Drug	piperazine dihydrochloride	HTR2A HTR2B HTR2C	4.97e-05	16	104	3	CID000008893
Drug	5-methyltryptamine	HTR2A HTR2B HTR2C	6.01e-05	17	104	3	CID000015760
Drug	Pergolide	HTR2A HTR2B HTR2C	6.01e-05	17	104	3	DB01186
Drug	zatosetron	HTR2A HTR2B HTR2C	6.01e-05	17	104	3	CID000060763
Drug	Fenfluramine	HTR2B HTR2C	6.18e-05	3	104	2	DB00574
Drug	9-(2-Deoxy-5-O-Phosphono-Beta-D-Erythro-Pentofuranosyl)-6-(Phosphonooxy)-9h-Purine	HTR2B HTR2C	6.18e-05	3	104	2	CID009549204
Drug	6-methoxymianserin	HTR2A HTR2C	6.18e-05	3	104	2	ctd:C461657
Drug	1,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzotriazepine	HTR2A HTR2C	6.18e-05	3	104	2	ctd:C507420
Drug	gamma-mangostin	HTR2A HTR2C	6.18e-05	3	104	2	ctd:C102777
Drug	spiramide	HTR2B HTR2C	6.18e-05	3	104	2	CID000068186
Drug	WAY-181187	HTR2B HTR2C	6.18e-05	3	104	2	CID010150497
Drug	ketanserinol	HTR2B HTR2C	6.18e-05	3	104	2	CID000156394
Drug	psilocin	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	CID000004980
Drug	SB 242084	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	CID003644637
Drug	Bromocriptine	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	DB01200
Drug	mescaline	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	CID000004076
Drug	benzoctamine	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	CID000028425
Drug	spirodecanone	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	CID000070556
Drug	DP-5-CT	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	CID000156314
Drug	RS 102221	HTR2A HTR2B HTR2C	7.19e-05	18	104	3	CID003693566
Drug	NSC186067	HTR2A HTR2B HTR2C	8.51e-05	19	104	3	CID000004140
Drug	SB 200646A	HTR2A HTR2B HTR2C	8.51e-05	19	104	3	CID000126769
Drug	MDL 11,939	HTR2A HTR2B HTR2C	8.51e-05	19	104	3	CID000071781
Drug	femoxitine	HTR2A HTR2B HTR2C	8.51e-05	19	104	3	CID000043103
Drug	RP 62203	HTR2A HTR2B HTR2C	8.51e-05	19	104	3	CID000060785
Drug	ICI 169,369	HTR2A HTR2B HTR2C	9.97e-05	20	104	3	CID000122265
Drug	Doxepin	HTR2A HTR2B HTR2C	9.97e-05	20	104	3	DB01142
Drug	5-fluoro-8-hydroxy-2-(dipropylamino)tetralin	HTR2A HTR2B HTR2C	9.97e-05	20	104	3	CID000005122
Drug	SCH 39166	HTR2A HTR2B HTR2C	9.97e-05	20	104	3	CID000107930
Drug	SB224289	HTR2A HTR2B HTR2C	9.97e-05	20	104	3	CID003378093
Drug	eltoprazine	HTR2A HTR2B HTR2C	1.16e-04	21	104	3	CID000065853
Drug	ziram	HTR2A HTR2B HTR2C	1.16e-04	21	104	3	CID000008722
Drug	5-CT	HTR2A HTR2B HTR2C ADORA3	1.17e-04	55	104	4	CID000001809
Drug	Loxapine	HTR2A HTR2C	1.23e-04	4	104	2	DB00408
Drug	mesulergine	HTR2B HTR2C	1.23e-04	4	104	2	ctd:C031649
Drug	gamma-valerolactone	HTR2A HTR2C	1.23e-04	4	104	2	CID000007921
Drug	tropanserin	HTR2B HTR2C	1.23e-04	4	104	2	CID000068599
Drug	glycerylcysteine	TLR6 TLR1	1.23e-04	4	104	2	CID000152469
Drug	trimethoxyamphetamine	HTR2B HTR2C	1.23e-04	4	104	2	CID000031016
Drug	AC1L19UR	HTR2B HTR2C	1.23e-04	4	104	2	CID000025833
Drug	SB-243213	HTR2B HTR2C	1.23e-04	4	104	2	CID000443391
Drug	BW 723C86	HTR2A HTR2B HTR2C	1.34e-04	22	104	3	CID004284720
Drug	zacopride	HTR2A HTR2B HTR2C	1.34e-04	22	104	3	CID000108182
Drug	mCPBG	HTR2A HTR2B HTR2C	1.34e-04	22	104	3	CID000001354
Disease	anxiety disorder (implicated_via_orthology)	NPY1R HTR2C SCN1A SCN3A	7.99e-07	22	98	4	DOID:2030 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ABCA3 HTR2A HTR2B HTR2C SCN1A	1.57e-04	152	98	5	DOID:0060041 (implicated_via_orthology)
Disease	aspergillosis (is_implicated_in)	TLR6 TLR1	3.02e-04	8	98	2	DOID:13564 (is_implicated_in)
Disease	taste liking measurement	OR4N5 MYCBP2 OR2J3 OR2T34 TLR1 PKHD1 CCDC171	3.19e-04	388	98	7	EFO_0010155
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN3A	4.83e-04	10	98	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN3A	4.83e-04	10	98	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN3A	7.05e-04	12	98	2	DOID:0060170 (implicated_via_orthology)
Disease	Seasonal Affective Disorder	HTR2A HTR2C	1.27e-03	16	98	2	C0085159
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR6 TLR1	1.44e-03	17	98	2	DOID:8677 (biomarker_via_orthology)
Disease	androstenedione measurement, estrone measurement	OR4D1 OR4D2	1.61e-03	18	98	2	EFO_0007970, EFO_0007972
Disease	childhood aggressive behaviour measurement	RFX8 SCN1A COL14A1	3.28e-03	89	98	3	EFO_0007663

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHRMTTLFCINVLSE	PPP2R1A	496	P30153
CHLSRIVQATTLLTM	AFDN	841	P55196
SLRICTIAEHLETML	FAM200B	201	P0CF97
LASVRHMAETTEACI	EPG5	2316	Q9HCE0
VLFSTASIMHLCAIS	HTR2B	136	P41595
MTCLLLIFTHASIMS	ADORA3	86	P0DMS8
TGQVSVLVMCHTREL	DDX39B	111	Q13838
ISLVMECIPLHSSRS	CCDC171	916	Q6TFL3
VLFSTASIMHLCAIS	HTR2A	156	P28223
LFSTASIMHLCAISL	HTR2C	136	P28335
AIIITSHSMEECEAL	ABCA3	1566	Q99758
GHLLLTICTVRSMEQ	DOP1A	2381	Q5JWR5
CASSDTIRSIMLVAH	NPR3	261	P17342
IILAAISDSCLHTPM	OR7A2P	46	Q8NGA2
SSAAACELVLTTMHR	RAB11FIP5	101	Q9BXF6
CELVLTTMHRSLIGV	RAB11FIP5	106	Q9BXF6
LLALSCHEQEMVVSS	SLC2A12	71	Q8TD20
VAVHLFALMVSTCLL	ORAI3	106	Q9BRQ5
SHLCTSALLSKMVLI	LTN1	996	O94822
LHTSVVLLTEMCERS	AP1G1	191	O43747
ACMRTLLTHEASKLT	ANKRD31	1011	Q8N7Z5
AASTCTTHIIVVSMI	OR4D2	236	P58180
IVVSIHTETCLCTSM	OR10W1	36	Q8NGF6
LMTLTLCVHLVVASV	OR10W1	126	Q8NGF6
KALVTCSSHLIVVGM	OR2AG2	236	A6NM03
TTIMSHSLCILLVAV	OR4C12	131	Q96R67
QSLMATKHSLECSLT	KRT28	321	Q7Z3Y7
SISNMISLHVLILCC	LRRD1	551	A4D1F6
HMVSLACSDILVFLI	GPR39	71	O43194
ISVLCTSLATMLHVE	GPN2	156	Q9H9Y4
NCTALMVSHILQSEL	FRMD7	116	Q6ZUT3
HMDEVCSSQLLTSVR	PCM1	1611	Q15154
ILIVTVTTCDSSLHM	OR14C36	41	Q8NHC7
RLKTLSTCLSHMSTV	OR51H1	236	Q8NH63
KALSTCSAHIMVVTL	OR4K14	236	Q8NGD5
AISTCTTHIIIIFLM	OR4N5	236	Q8IXE1
STCGSHVITVLLVLM	OR4S1	236	Q8NGB4
AVMVLSCSDRHISEL	OR5B3	181	Q8NH48
VSHLKLCAGIMITAS	PGM2	151	Q96G03
CLLSILGSTVMVIHA	NIPA2	116	Q8N8Q9
SISVVLASIAAMCIH	KCNS1	226	Q96KK3
SLSVVLASIVAMCVH	KCNS3	191	Q9BQ31
LVMASEDALCTVLHL	GCN1	531	Q92616
KALVTCSSHLTVVGM	OR2AG1	236	Q9H205
KALATCSSHMIIVLL	OR2T34	241	Q8NGX1
KALATCSSHMIIVLL	OR2T3	241	Q8NH03
ALSTCTSHMLVVTLH	OR4D6	236	Q8NGJ1
FHAILSLVMCVSSLT	MAS1L	231	P35410
LSCSDTHLSEVMILT	OR1F2P	186	Q96R84
LFLLCHLTAMISTCV	NPY1R	301	P25929
SDTLVCVMCIHFTII	NPY6R	81	Q99463
LNLVTDCMEHALTSV	HSD17B6	261	O14756
ILISHFVACMTAILN	DOCK2	931	Q92608
ATMKDFTSLCLHLTV	CCNF	321	P41002
DLMHTVVESLTRTLC	COL14A1	321	Q05707
TSMLHFVTSICARLL	GRPR	296	P30550
STCLDVFEHISLMTL	CYP4F8	186	P98187
NMVIVIHSLLDICSV	C1orf112	156	Q9NSG2
IHSLLDICSVISSMD	C1orf112	161	Q9NSG2
EAMLSTTACIVLSHQ	DTHD1	501	Q6ZMT9
INSLITTDMCSSLVH	DCLRE1A	916	Q6PJP8
AIALMTTAVISTCDH	DKC1	346	O60832
VASIISSFLQCTHML	SERHL2	296	Q9H4I8
TCSLLAIAIERHLTM	S1PR3	126	Q99500
MCSSILSLAQSLLHS	FANCD2	431	Q9BXW9
AASTCTTHIIVVSMI	OR4D1	236	Q15615
ISCDFILLSILKMHS	OR5T3	246	Q8NGG3
HLSFLDMTISCAIVP	OR10G6	86	Q8NH81
VLLMSRLSFCASHII	OR1L4	161	Q8NGR5
SCVDTHVNELTLMIT	OR2J3	191	O76001
VIVCIMGTVSDTLHR	MROH5	1096	Q6ZUA9
QILLCMTATVSHILD	UTP20	1121	O75691
MLLLGTVHCQIVSTR	PHTF2	176	Q8N3S3
IVAMIVLHACSLRSV	TMEM150B	166	A6NC51
HVSATLACLTAIIQM	SLC26A9	171	Q7LBE3
AVHVVRVLTCIMSDS	NBEAL2	381	Q6ZNJ1
SVDSVHTLTCAIMLL	PSD4	676	Q8NDX1
HTLTCAIMLLNTDLH	PSD4	681	Q8NDX1
TMSSSTEVSRCIAHL	SLTM	431	Q9NWH9
RLLAAVMSALCHTSV	MYCBP2	1586	O75592
VMSALCHTSVKLTSI	MYCBP2	1591	O75592
RSHILASMETLSASC	PKHD1	2536	P08F94
VHSLFSMLIMCTILT	SCN3A	126	Q9NY46
PSHTSSNCLVITIME	RNF182	121	Q8N6D2
SCTDTHVLELMSFTL	OR6C6	186	A6NF89
CSETLLRVMTLSHVL	RRP12	326	Q5JTH9
LRVMTLSHVLVTACA	RRP12	331	Q5JTH9
MVSCSILALTHLLFE	RRP12	916	Q5JTH9
VHSLFSMLIMCTILT	SCN1A	126	P35498
HMSELSCNITLLIVT	TLR1	571	Q15399
LSRSLMLENTECHSI	WDR47	356	O94967
SVISNSCVTMERLSH	ZNF568	6	Q3ZCX4
TTHCDEVLRLILTHM	TTI2	336	Q6NXR4
IHTLTCALMLLNTDL	PSD2	406	Q9BQI7
DSTTMVSCLHILAQT	RYR3	2921	Q15413
LLTAVSKAMTLCHRD	RFX8	406	Q6ZV50
VSTTFLVHLVVMSDL	ZDHHC4	211	Q9NPG8
VSALTQMESACVSIH	TMED7	141	Q9Y3B3
IMCLLICSRHSLTQS	RAET1G	236	Q6H3X3
LFTCEIEMLLHVVST	NUP188	541	Q5SRE5
TLDLVMKTLSSHTSC	PPP1R36	406	Q96LQ0
MLRTCAVHITLDPDT	TRIM21	281	P19474
HMSELSCNITLLIVT	TLR6	576	Q9Y2C9
TVMSNSTIVRLHLDC	ZSWIM6	956	Q9HCJ5
LDSSAVHRILKMIVC	VPS13B	586	Q7Z7G8
VAKVMSSLCTITDHL	ZZEF1	486	O43149
ATLSLHSLFELRTCM	SLC4A4	151	Q9Y6R1
VHVTLTNTLMVALSS	TGM7	626	Q96PF1
TLHRVTTISMARCTL	VIRMA	996	Q69YN4
VITSVPSELCLHEMS	WNK3	1206	Q9BYP7
HITALFECSMAAIIT	JKAMP	91	Q9P055
SVSHIRNTMLSLCLE	PDE4DIP	1041	Q5VU43
MTETTKTHVILLACG	NMNAT2	1	Q9BZQ4