Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.53e-1437468GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.94e-1438468GO:0070001
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

7.35e-1014124618GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF735 ZNF189

8.96e-1012444617GO:0000978
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

1.24e-0914594618GO:0000977
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF735 ZNF189

1.24e-0912714617GO:0000987
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

8.04e-0911464GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

2.43e-0814464GO:0003964
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-8 ERVK-6 ERVK-7 ERVK-10

1.43e-0721464GO:0035613
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-8 ADAMTS10 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

4.98e-07430469GO:0004175
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-8 ERVK-6 ERVK-7 ERVK-10

1.54e-0637464GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

1.72e-0638464GO:0034061
GeneOntologyMolecularFunctionpeptidase activity

ERVK-8 ADAMTS10 METAP1 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.86e-066544610GO:0008233
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-8 ERVK-6 ERVK-7 ERVK-10

3.75e-0646464GO:0016893
GeneOntologyMolecularFunctionzinc ion binding

ERVK-8 ERVK-6 ZCCHC4 UBR3 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 ZNF92

4.17e-068914611GO:0008270
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

3.26e-0579464GO:0004521
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-8 ERVK-6 ZCCHC4 UBR3 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 ZNF92

6.16e-0511894611GO:0046914
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-8 THSD4 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.67e-04891469GO:0005198
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

2.69e-04136464GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

2.69e-04136464GO:0004519
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

4.11e-04152464GO:0016779
GeneOntologyMolecularFunctionnuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10

1.95e-03231464GO:0004518
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-8 ERVK-6 ZCCHC4 ERVK-7 ERVK-10

2.63e-03417465GO:0140098
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-8 ERVK-6 ERVK-7 ERVK-10

3.07e-03262464GO:0140097
GeneOntologyBiologicalProcessDNA integration

ERVK-8 ERVK-6 ERVK-7 ERVK-10

1.53e-0813464GO:0015074
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

1.27e-0685465GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

1.27e-0685465GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

1.59e-0689465GO:0006949
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-8 ERVK-6 ERVK-7 ERVK-10

3.92e-0648464GO:0000731
GeneOntologyBiologicalProcessviral process

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

7.61e-06464468GO:0016032
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

ERVK-8 ERVK-6 ERVK-7 ERVK-10

3.50e-0583464GO:0006278
GeneOntologyBiologicalProcessDNA-templated DNA replication

ERVK-8 ERVK-6 ERVK-7 ERVK-10

6.59e-04178464GO:0006261
GeneOntologyCellularComponentmicrofibril

THSD4 ADAMTS10

3.64e-0413462GO:0001527
DomainKRAB

ZNF737 ZNF429 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF92 ZNF735 ZNF189

2.14e-163583915PS50805
DomainKRAB

ZNF737 ZNF429 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF92 ZNF735 ZNF189

2.14e-163583915PF01352
Domain-

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

3.01e-1667939183.30.160.60
DomainKRAB

ZNF737 ZNF429 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF92 ZNF735 ZNF189

3.36e-163693915SM00349
DomainKRAB

ZNF737 ZNF429 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF92 ZNF735 ZNF189

3.50e-163703915IPR001909
Domainzf-C2H2

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

4.30e-166933918PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

4.41e-166943918IPR013087
DomainZINC_FINGER_C2H2_2

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

3.01e-157753918PS50157
DomainZINC_FINGER_C2H2_1

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

3.15e-157773918PS00028
DomainZnf_C2H2-like

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

4.79e-157963918IPR015880
DomainZnf_C2H2

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

5.81e-158053918IPR007087
DomainZnF_C2H2

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

6.20e-158083918SM00355
Domainzf-C2H2_6

ZNF737 ZNF429 ZNF761 ZNF225 ZNF605 ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF735

2.81e-113143911PF13912
DomainRetrov_capsid_C

ADAMTS10 ERVK-6 ZNF18

2.52e-0459393IPR008916
DomainPLAC

THSD4 ADAMTS10

3.81e-0414392PF08686
DomainPLAC

THSD4 ADAMTS10

7.10e-0419392IPR010909
DomainPLAC

THSD4 ADAMTS10

7.10e-0419392PS50900
DomainADAM_spacer1

THSD4 ADAMTS10

1.05e-0323392IPR010294
DomainADAM_spacer1

THSD4 ADAMTS10

1.05e-0323392PF05986
DomainZF_CCHC

ERVK-6 ZCCHC4

2.42e-0335392PS50158
DomainZnF_C2HC

ERVK-6 ZCCHC4

5.88e-0355392SM00343
DomainZnf_CCHC

ERVK-6 ZCCHC4

5.88e-0355392IPR001878
DomainTSP_1

THSD4 ADAMTS10

7.66e-0363392PF00090
DomainTSP1

THSD4 ADAMTS10

8.13e-0365392SM00209
DomainTSP1_rpt

THSD4 ADAMTS10

8.13e-0365392IPR000884
DomainTSP1

THSD4 ADAMTS10

8.13e-0365392PS50092
DomainEGF_Ca-bd_CS

EYS LRP1B

1.75e-0297392IPR018097
DomainEGF_CA

EYS LRP1B

1.81e-0299392PS01187
DomainASX_HYDROXYL

EYS LRP1B

1.85e-02100392PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

EYS LRP1B

2.06e-02106392IPR000152
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF737 ZNF429 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF92 ZNF735 ZNF189

1.49e-0813872915M734
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

5.04e-139446821542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

2.54e-121246514557543
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10 ERVK-24

2.68e-12446410469592
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-7 ERVK-21

1.34e-11546412629516
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-10 ERVK-24

8.08e-091846418664271
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19 ERVK-10

8.65e-0944637983737
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19 ERVK-9

4.32e-08646315063128
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19 ERVK-21

2.58e-071046312970426
Pubmed

Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

ZNF737 ZNF99 ZNF92

1.20e-06164638467795
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.71e-0624629060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.71e-0624629460924
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF737 ZCCHC4 ZNF33B ZNF273 ZNF92

4.16e-0618146537372979
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

5.13e-06346210516026
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

5.13e-0634629971820
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF429 ZNF716 ZNF99

7.72e-062946314563677
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

1.71e-05546211401426
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CFH METAP1 ZNF18 ABLIM1 ZNF350 ZNF605 LRP1B ZNF92 ZNF189

4.00e-05128546935914814
Pubmed

Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.

ZNF18 ZNF33B

1.54e-04144622014798
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF429 ZNF99

1.78e-041546215885501
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF429 ZNF273

3.54e-04214627865130
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF429 ZNF322 ZNF18 ABLIM1 ZNF716 ZNF99

6.55e-0480846620412781
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF18 ZNF33B

7.77e-04314622288909
Pubmed

Genome-wide association study identifies eight loci associated with blood pressure.

CLCN6 ZNF652

8.28e-043246219430483
Pubmed

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.

THSD4 LRP1B

8.80e-043346224159190
Cytoband7q11.21

ZNF273 ZNF92 ZNF735

7.65e-05834537q11.21
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF737 ZNF429 ZNF99

2.39e-04122453chr19p12
CytobandEnsembl 112 genes in cytogenetic band chr7q11

ZNF273 ZNF92 ZNF735

2.40e-03271453chr7q11
Cytoband19p12

ZNF737 ZNF99

3.56e-039045219p12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF737 ZNF429 ZNF322 ZNF18 ZNF350 ZNF761 ZNF716 ZNF225 ZNF605 ZNF33B ZNF99 ZNF273 ZIM3 ZNF652 ZNF92 ZNF491 ZNF735 ZNF189

5.95e-17718341828
Diseasesevere acute respiratory syndrome, COVID-19

THSD4 ZCCHC4 ABLIM1 EYS LRP1B

2.59e-04447385EFO_0000694, MONDO_0100096
Diseaselumbar disc degeneration

EYS CRBN

5.98e-0428382EFO_0004994
Diseasedisease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement

THSD4 LRP1B

8.31e-0433382EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090
Diseaseleft ventricular mass index

ADAMTS10 CLCN6

8.83e-0434382EFO_0009290
Diseasecalcium measurement

CFH METAP1 LTO1 LRP1B TLE4

1.21e-03628385EFO_0004838

Protein segments in the cluster

PeptideGeneStartEntry
FSKCVSKKCWAHGVE

AKAP14

86

Q86UN6
ALDKQWHLGCFKCKS

ABLIM1

241

O14639
CKICASHIGWKFTAT

CRBN

391

Q96SW2
HCSDDGFWSKEKPKC

CFH

191

P08603
HAGKSLDSFCKWQKS

ADAMTS10

306

Q9H324
FSGEKKLCTHKNWCN

OSMR

281

Q99650
KSGRCISSKWHCDSD

LRP1B

976

Q9NZR2
DHKTKFSCWSTGRCI

LRP1B

1096

Q9NZR2
CSQECFKGSWATHKL

METAP1

36

P53582
HGKCLSEAWSKTYSC

EYS

186

Q5T1H1
SWDKAHAKCKAFSSD

LY75

381

O60449
CSSKWSKYKHDLAAS

DSE

506

Q9UL01
KKGKHWASQCRSKFD

ERVK-10

586

P87889
KKGKHWASQCRSKFD

ERVK-19

586

Q9YNA8
KKGKHWASQCRSKFD

ERVK-21

586

P62683
KKGKHWASQCRSKFD

ERVK-24

586

P63145
KKGKHWASQCRSKFD

ERVK-6

586

Q7LDI9
KKGKHWASQCRSKFD

ERVK-7

586

P63130
KKGKHWASQCRSKFD

ERVK-8

586

P62685
KKGKHWASQCRSKFD

ERVK-9

586

P63126
KKGKHWASQCRSKFD

HERVK_113

586

P62684
EFKCSDSDKKCHLWT

CLCN6

316

P51797
FAWKCLLHSCTTEKD

LTO1

61

Q8WV07
SCHCKITFCKAKYWS

OSBPL7

666

Q9BZF2
RCKWTKSEAHSCSKH

PNPLA8

56

Q9NP80
KKGKHWASQCRSKFD

ERVK-9

586

P63128
CEECGKAFKWSSHLT

ZNF99

651

A8MXY4
KCSDCGKAFSWKSHL

ZNF189

261

O75820
CGKAFSWKSSCINHE

ZIM3

256

Q96PE6
CGKAFNWSSTLTKHK

ZNF273

351

Q14593
CGKAFNWSSTLTKHK

ZNF273

491

Q14593
CGKAFNWSSTLTKHK

ZNF92

206

Q03936
ECGKTFSWKSSLTCH

ZNF761

526

Q86XN6
CDKAFKWHSSLAKHK

ZNF735

386

P0CB33
CNECGKAFWEKSHLT

ZNF33B

331

Q06732
ESCVLSLKFAHCGKW

TLE4

701

Q04727
CSKCEKSFWHHLALS

ZNF322

101

Q6U7Q0
CGKAFSWSASLTKHK

ZNF716

246

A6NP11
FSAWHWCPCSGKKKK

SLAMF8

251

Q9P0V8
HVCSECGKAFIKKSW

ZNF350

206

Q9GZX5
CEKCGKSFRWASTHL

ZNF225

626

Q9UK10
AWKHAGALKKSTCDA

UBR3

1586

Q6ZT12
TSKDGRKWNHCFLCK

ZCCHC4

401

Q9H5U6
CGKAFNWSSTLTKHK

ZNF429

346

Q86V71
CKQCGKAFSWHSSVR

ZNF491

161

Q8N8L2
KCSHCGKSFSWSSSL

ZNF18

521

P17022
SCHLKPCGAKWFSTE

THSD4

906

Q6ZMP0
CVSCNKSFKKLWSLH

ZNF652

301

Q9Y2D9
CSHCGKAFFWKSQLI

ZNF605

311

Q86T29
FKCEECGKAFNWSSH

ZNF737

201

O75373