Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	FLT1 EPHA6 NRP1 MET FGFR1	2.57e-04	65	174	5	GO:0004714
GeneOntologyMolecularFunction	BAT3 complex binding	USP13 VCP	4.48e-04	4	174	2	GO:1904288
GeneOntologyMolecularFunction	HLA-E specific inhibitory MHC class Ib receptor activity	KLRC1 KLRC2	4.48e-04	4	174	2	GO:0062082
GeneOntologyMolecularFunction	inhibitory MHC class Ib receptor activity	KLRC1 KLRC2	4.48e-04	4	174	2	GO:0062080
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP13 ZC3H12A USP11 USP43 USP19 MINDY3	4.92e-04	114	174	6	GO:0004843
GeneOntologyMolecularFunction	MHC class Ib receptor activity	LILRB2 KLRC1 KLRC2	5.69e-04	19	174	3	GO:0032394
GeneOntologyMolecularFunction	calmodulin-dependent protein phosphatase activity	PPP3CA PPP3CB	7.42e-04	5	174	2	GO:0033192
GeneOntologyMolecularFunction	deubiquitinase activity	USP13 ZC3H12A USP11 USP43 USP19 MINDY3	7.68e-04	124	174	6	GO:0101005
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP13 USP19 MINDY3	7.71e-04	21	174	3	GO:1990380
GeneOntologyBiologicalProcess	vesicle-mediated transport to the plasma membrane	GGA2 ARFGEF2 EIPR1 EHD3 EHD2 GOLPH3L NSG1 EHD1 MACF1	1.39e-05	172	171	9	GO:0098876
GeneOntologyBiologicalProcess	stimulatory C-type lectin receptor signaling pathway	PAK2 KLRC1 KLRC2 KLRC3	3.57e-05	23	171	4	GO:0002223
GeneOntologyBiologicalProcess	cellular response to lectin	PAK2 KLRC1 KLRC2 KLRC3	3.57e-05	23	171	4	GO:1990858
GeneOntologyBiologicalProcess	response to lectin	PAK2 KLRC1 KLRC2 KLRC3	3.57e-05	23	171	4	GO:1990840
GeneOntologyBiologicalProcess	dendrite morphogenesis	TNIK DSCAM NRP1 MET PPP3CA PTPRF ANAPC2 MFN2 CTNNA2	4.21e-05	198	171	9	GO:0048813
GeneOntologyBiologicalProcess	positive regulation of endocytic recycling	EIPR1 EHD2 EHD1	4.53e-05	9	171	3	GO:2001137
GeneOntologyBiologicalProcess	protein deubiquitination	USP13 ZC3H12A USP11 USP43 USP19 MINDY3 VCP	8.35e-05	125	171	7	GO:0016579
GeneOntologyBiologicalProcess	hepatocyte growth factor receptor signaling pathway	NRP1 ADAMTS12 MET	1.17e-04	12	171	3	GO:0048012
GeneOntologyBiologicalProcess	neuron projection morphogenesis	TNIK EPHA6 DSCAM NR4A2 NRP1 MET PPP3CA DST PPP3CB HMCN2 PTPRF ANAPC2 PAK2 MFN2 MACF1 CTNNA2 MAP4K4 MYO16	1.25e-04	802	171	18	GO:0048812
GeneOntologyCellularComponent	ciliary pocket membrane	EHD3 EHD1	2.25e-04	3	182	2	GO:0020018
GeneOntologyCellularComponent	ciliary pocket	EHD3 EHD1	2.25e-04	3	182	2	GO:0020016
MousePheno	abnormal metencephalon morphology	TNIK GALC DSCAM NEUROD4 GPR37L1 NRP1 MET DST GLB1 CACNA1G FGFR1 CTNNA2 HERC2 HERC1 DNAH5	9.05e-06	420	131	15	MP:0000847
Domain	G_DYNAMIN_dom	EHD3 EHD2 EHD1 MFN2	6.93e-06	14	175	4	IPR030381
Domain	G_DYNAMIN_2	EHD3 EHD2 EHD1 MFN2	6.93e-06	14	175	4	PS51718
Domain	EHD_N	EHD3 EHD2 EHD1	7.98e-06	5	175	3	IPR031692
Domain	EHD_N	EHD3 EHD2 EHD1	7.98e-06	5	175	3	PF16880
Domain	Dynamin_GTPase	EHD3 EHD2 EHD1 MFN2	9.38e-06	15	175	4	IPR001401
Domain	Dynamin_SF	EHD3 EHD2 EHD1 MFN2	9.38e-06	15	175	4	IPR022812
Domain	Dynamin_N	EHD3 EHD2 EHD1 MFN2	9.38e-06	15	175	4	PF00350
Domain	GAR	GAS2L3 DST MACF1	1.58e-05	6	175	3	PS51460
Domain	GAS2	GAS2L3 DST MACF1	1.58e-05	6	175	3	PF02187
Domain	-	GAS2L3 DST MACF1	1.58e-05	6	175	3	3.30.920.20
Domain	GAS_dom	GAS2L3 DST MACF1	1.58e-05	6	175	3	IPR003108
Domain	GAS2	GAS2L3 DST MACF1	1.58e-05	6	175	3	SM00243
Domain	DUF1220	NBPF11 NBPF9 NBPF7P	6.52e-05	9	175	3	SM01148
Domain	Peptidase_S26B	SEC11C SEC11A	8.73e-05	2	175	2	IPR001733
Domain	Pept_S26A_signal_pept_1_Ser-AS	SEC11C SEC11A	8.73e-05	2	175	2	IPR019756
Domain	EHD1/EHD3	EHD3 EHD1	8.73e-05	2	175	2	IPR029951
Domain	EF-hand_4	EHD3 EHD2 EHD1	9.25e-05	10	175	3	PF12763
Domain	DUF1220	NBPF11 NBPF9 NBPF7P	1.26e-04	11	175	3	PF06758
Domain	NBPF_dom	NBPF11 NBPF9 NBPF7P	1.26e-04	11	175	3	IPR010630
Domain	EH	EHD3 EHD2 EHD1	1.26e-04	11	175	3	PS50031
Domain	NBPF	NBPF11 NBPF9 NBPF7P	1.26e-04	11	175	3	PS51316
Domain	EH	EHD3 EHD2 EHD1	1.26e-04	11	175	3	SM00027
Domain	EH_dom	EHD3 EHD2 EHD1	1.26e-04	11	175	3	IPR000261
Domain	Kinase-like_dom	TNIK FLT1 EPHA6 MAP3K14 ALPK1 MET STK10 DST PAK2 MACF1 ETNK1 FGFR1 OXSR1 PRKG2 MAP4K4	1.84e-04	542	175	15	IPR011009
Domain	Pept_S26A_signal_pept_1_CS	SEC11C SEC11A	2.60e-04	3	175	2	IPR019758
Domain	IGc2	A1BG NPHS1 FLT1 DSCAM LRIG2 HMCN2 PTPRF FGFR1 MYBPC2	3.83e-04	235	175	9	SM00408
Domain	Ig_sub2	A1BG NPHS1 FLT1 DSCAM LRIG2 HMCN2 PTPRF FGFR1 MYBPC2	3.83e-04	235	175	9	IPR003598
Domain	Ig_I-set	NPHS1 FLT1 DSCAM LRIG2 HMCN2 PTPRF FGFR1 MYBPC2	4.33e-04	190	175	8	IPR013098
Domain	I-set	NPHS1 FLT1 DSCAM LRIG2 HMCN2 PTPRF FGFR1 MYBPC2	4.33e-04	190	175	8	PF07679
Domain	SPASE_I_3	SEC11C SEC11A	5.17e-04	4	175	2	PS00761
Domain	-	SEC11C SEC11A	5.17e-04	4	175	2	2.10.109.10
Domain	SPASE_I_1	SEC11C SEC11A	5.17e-04	4	175	2	PS00501
Domain	Peptidase_S24/S26_b-rbn	SEC11C SEC11A	5.17e-04	4	175	2	IPR028360
Domain	Peptidase_S24	SEC11C SEC11A	5.17e-04	4	175	2	PF00717
Domain	Peptidase_S24_S26A/B/C	SEC11C SEC11A	5.17e-04	4	175	2	IPR015927
Domain	Peptidase_S24_S26	SEC11C SEC11A	5.17e-04	4	175	2	IPR019759
Domain	-	EPHA6 F8 NRP1 GLB1 HERC2	6.12e-04	73	175	5	2.60.120.260
Domain	Protein_kinase_ATP_BS	TNIK FLT1 EPHA6 MAP3K14 MET STK10 PAK2 FGFR1 OXSR1 PRKG2 MAP4K4	9.18e-04	379	175	11	IPR017441
Domain	Spectrin	SYNE3 DST MACF1	1.25e-03	23	175	3	PF00435
Domain	-	DST MACF1	1.28e-03	6	175	2	3.90.1290.10
Domain	Gonadotropin_bsu_CS	CGB3 CGB1	1.28e-03	6	175	2	IPR018245
Domain	Plectin	DST MACF1	1.78e-03	7	175	2	PF00681
Domain	GLYCO_HORMONE_BETA_1	CGB3 CGB1	1.78e-03	7	175	2	PS00261
Domain	Plectin_repeat	DST MACF1	1.78e-03	7	175	2	IPR001101
Domain	Gonadotropin_bsu	CGB3 CGB1	1.78e-03	7	175	2	IPR001545
Domain	GLYCO_HORMONE_BETA_2	CGB3 CGB1	1.78e-03	7	175	2	PS00689
Domain	GHB	CGB3 CGB1	1.78e-03	7	175	2	SM00068
Domain	PLEC	DST MACF1	1.78e-03	7	175	2	SM00250
Domain	Galactose-bd-like	EPHA6 F8 NRP1 GLB1 HERC2	1.91e-03	94	175	5	IPR008979
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF8 NBPF12 NBPF11 NBPF19 NBPF9 NBPF10 NBPF7P	1.09e-11	21	183	7	16079250
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 USP13 DSCAM TTC28 CORO2A ATP13A1 USP11 IFT172 TNPO2 NR4A2 GPR37L1 ARFGEF2 TFIP11 UBASH3A FOCAD PPP3CA DST PPP3CB TMEM168 PAK2 PRMT2 MACF1 HERC2 MAP4K4 VCP AGAP1 PCNT	9.55e-10	1285	183	27	35914814
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	USP13 TTC28 EML4 RALGAPB GON4L FAM91A1 TFIP11 URGCP DDX1 SPAG5 NRP1 PACS1 DST GLB1 TLL1 ANAPC2 HPS5 MAP4K4	1.22e-08	650	183	18	38777146
Pubmed	C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?	EHD3 EHD2 EHD1	5.71e-07	4	183	3	16155252
Pubmed	Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.	EHD3 EHD2 EHD1	5.71e-07	4	183	3	15020713
Pubmed	Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.	KLRC1 KLRC2 KLRC3	5.71e-07	4	183	3	8943374
Pubmed	Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.	MAP3K14 PPP3CA PPP3CB	5.71e-07	4	183	3	26029823
Pubmed	Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.	EHD3 EHD2 EHD1	5.71e-07	4	183	3	17233914
Pubmed	EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.	EHD3 EHD2 EHD1	5.71e-07	4	183	3	10673336
Pubmed	EH domain proteins regulate cardiac membrane protein targeting.	EHD3 EHD2 EHD1	1.42e-06	5	183	3	20489164
Pubmed	Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.	PPP3CA KLRC1 KLRC2	1.42e-06	5	183	3	21540458
Pubmed	Development and function of CD94-deficient natural killer cells.	KLRC1 KLRC2 KLRC3	1.42e-06	5	183	3	21151939
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNIK TTC28 IFT172 RALGAPB GON4L FAM91A1 ADCY2 USP19 FOCAD MFN2 MACF1 PCNT	1.90e-06	407	183	12	12693553
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	TNIK SLC4A8 USP43 ARFGEF2 EHD2 MET STK10 PACS1 PPP3CB PTPRF PROM2 EHD1 MAP4K4 AGAP1	2.18e-06	569	183	14	30639242
Pubmed	Structural basis for NKG2A/CD94 recognition of HLA-E.	KLRC1 KLRC2 KLRC3	2.83e-06	6	183	3	18448674
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TNIK TTC28 RALGAPB ALPK1 DST MACF1 CACNA1G HPS5 PCNT	3.32e-06	225	183	9	12168954
Pubmed	The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors.	USP13 USP43 ARFGEF2 EHD2 EHD1	4.39e-06	46	183	5	30659120
Pubmed	Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.	KLRC1 KLRC2 KLRC3	4.94e-06	7	183	3	9598306
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	TNIK EHD3 STK10 PACS1 DST PTPRF SLC20A1 EHD1 CTNNA2 MAP4K4 AGAP1	5.67e-06	377	183	11	38117590
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	A1BG NPHS1 EPHX2 CCT3 ALDH8A1 IRF6 NEB EHD2 FAH MMP24 SLC12A3 GLB1 PROM2 EHD1 HPX LTA4H OXSR1 VCP	7.82e-06	1016	183	18	19056867
Pubmed	Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing.	KLRC1 KLRC2 KLRC3	7.87e-06	8	183	3	33765134
Pubmed	Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells.	KLRC1 KLRC2 KLRC3	7.87e-06	8	183	3	10601355
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP13 USP11 URGCP USP19 DST MACF1 HERC2 HERC1 VCP CAPN15 PCNT UBFD1	1.03e-05	481	183	12	28190767
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	SLC4A8 RALGAPB GPR37L1 AGAP11 GPR162 EHD3 SLC20A1 EHD1 MFN2 TMX3 AGAP1	1.11e-05	405	183	11	38187761
Pubmed	Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I.	KLRC1 KLRC2 KLRC3	1.18e-05	9	183	3	14707119
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF12 NBPF9	1.67e-05	10	183	3	22973535
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	GAS2L3 FAM91A1 TFIP11 NCOA4 SPAG5 EHD3 PACS1 KLHL5 PPP3CB CGB1 SLC20A1 OR10AD1 SLC25A38 MACF1 DOT1L HERC1 TMX3 PCNT	1.86e-05	1084	183	18	11544199
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF8 NBPF12 TTC28 IFT172 NLRP1 NBPF11 NEB DST NBPF9 NBPF10 HERC2 CAPN15	1.95e-05	513	183	12	25798074
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	TNIK GGA2 AGAP11 PACS1 MAP4K4 MYO16 VCP AGAP1	2.19e-05	218	183	8	33378226
Pubmed	Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.	FLT1 NRP1 MET	2.29e-05	11	183	3	17981115
Pubmed	The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.	EHD3 EHD2 EHD1	2.29e-05	11	183	3	26455409
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ATP13A1 MTMR8 ARFGEF2 FOCAD FZD7 STK10 SYNE3 DST PNPLA6 PTPRF PROM2 MFN2 FGFR1 HERC2 DOT1L HERC1 AHNAK2 PCNT	2.39e-05	1105	183	18	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GGA2 AGAP11 URGCP NUP205 DST ANAPC2 CACNA1G OXSR1 TMX3 HPS5 MAP4K4 AGAP1	2.63e-05	529	183	12	14621295
Pubmed	Oxygen modulates iron homeostasis by switching iron sensing of NCOA4.	NCOA4 HERC2	2.75e-05	2	183	2	37059186
Pubmed	A Comparison of Lysosomal Enzymes Expression Levels in Peripheral Blood of Mild- and Severe-Alzheimer's Disease and MCI Patients: Implications for Regenerative Medicine Approaches.	GALC GLB1	2.75e-05	2	183	2	28825628
Pubmed	Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.	DST MACF1	2.75e-05	2	183	2	11002341
Pubmed	Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder.	EHD1 MACF1	2.75e-05	2	183	2	34100076
Pubmed	Women with pre-eclampsia have an altered NKG2A and NKG2C receptor expression on peripheral blood natural killer cells.	KLRC1 KLRC2	2.75e-05	2	183	2	19694640
Pubmed	Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.	PPP3CA PPP3CB	2.75e-05	2	183	2	19861587
Pubmed	Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.	PPP3CA PPP3CB	2.75e-05	2	183	2	19907416
Pubmed	Chromosomal assignments of the genes for the calcineurin A alpha (Calna1) and A beta subunits (Calna2) in the rat.	PPP3CA PPP3CB	2.75e-05	2	183	2	8187553
Pubmed	Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.	PPP3CA PPP3CB	2.75e-05	2	183	2	1328240
Pubmed	SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.	EHD3 EHD1	2.75e-05	2	183	2	26226295
Pubmed	Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons.	NR4A2 PPP3CA	2.75e-05	2	183	2	24291696
Pubmed	Double Knockout of the Na+-Driven Cl-/HCO3- Exchanger and Na+/Cl- Cotransporter Induces Hypokalemia and Volume Depletion.	SLC4A8 SLC12A3	2.75e-05	2	183	2	27151921
Pubmed	Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.	PPP3CA PPP3CB	2.75e-05	2	183	2	11005320
Pubmed	NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control.	KLRC1 KLRC2	2.75e-05	2	183	2	39288262
Pubmed	Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.	PPP3CA PPP3CB	2.75e-05	2	183	2	2556704
Pubmed	Rhodocetin-αβ-induced neuropilin-1-cMet association triggers restructuring of matrix contacts in endothelial cells.	NRP1 MET	2.75e-05	2	183	2	23288161
Pubmed	Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses.	KLRC1 KLRC2	2.75e-05	2	183	2	15550116
Pubmed	Lacteal junction zippering protects against diet-induced obesity.	FLT1 NRP1	2.75e-05	2	183	2	30093598
Pubmed	Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.	PPP3CA PPP3CB	2.75e-05	2	183	2	35247520
Pubmed	Characterization of large-scale genomic differences in the first complete human genome.	KLRC2 KLRC3	2.75e-05	2	183	2	37403156
Pubmed	The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.	PPP3CA PPP3CB	2.75e-05	2	183	2	20810903
Pubmed	FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.	FGFR1 MAP4K4	2.75e-05	2	183	2	28771231
Pubmed	Calcineurin A-alpha but not A-beta is required for normal kidney development and function.	PPP3CA PPP3CB	2.75e-05	2	183	2	15509543
Pubmed	Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons.	SYNE3 DST	2.75e-05	2	183	2	18638474
Pubmed	DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis: Perspective of Different Water Iodine Exposure.	KLRC1 KLRC3	2.75e-05	2	183	2	39401997
Pubmed	PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells.	MET PRKG2	2.75e-05	2	183	2	27147579
Pubmed	Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation.	ZC3H12A MET	2.75e-05	2	183	2	36138026
Pubmed	Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy.	EPHX2 F8	2.75e-05	2	183	2	19126686
Pubmed	LoVo colon cancer cells resistant to oxaliplatin overexpress c-MET and VEGFR-1 and respond to VEGF with dephosphorylation of c-MET.	FLT1 MET	2.75e-05	2	183	2	25647613
Pubmed	Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A.	CORO2A USP19	2.75e-05	2	183	2	27129179
Pubmed	Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.	PPP3CA PPP3CB	2.75e-05	2	183	2	22739212
Pubmed	Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis.	IRF6 FGFR1	2.75e-05	2	183	2	17318851
Pubmed	Are calcineurin genes associated with athletic status? A function, replication study.	PPP3CA PPP3CB	2.75e-05	2	183	2	21233773
Pubmed	Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development.	PACS1 PAK2	2.75e-05	2	183	2	12855553
Pubmed	Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.	PPP3CA PPP3CB	2.75e-05	2	183	2	25286016
Pubmed	Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein.	SEC11C SEC11A	2.75e-05	2	183	2	2188978
Pubmed	Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.	PPP3CA PPP3CB	2.75e-05	2	183	2	25287476
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF8 USP13 NBPF12 TTC28 NBPF11 NBPF9 NBPF10	3.48e-05	170	183	7	23314748
Pubmed	Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.	CGB1 HERC2 HPS5	3.94e-05	13	183	3	8601493
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	LPCAT1 ATP13A1 RTN2 URGCP DDX1 USP19 SPAG5 NUP205 PNPLA6 PTPRF GLB1 SEC11A ANAPC2 TMX3 VCP CAPN15	4.22e-05	942	183	16	31073040
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	TNIK TFIP11 SPAG5 DST MACF1 HERC2	4.35e-05	120	183	6	31413325
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TNIK USP11 FAM91A1 TFIP11 NRP1 PTPRF SLC20A1 HERC2 MAP4K4	4.57e-05	313	183	9	38270169
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	CCT3 TNPO2 DDX1 NUP205 DST MACF1 CTNNA2 MAP4K4 VCP	4.80e-05	315	183	9	26777405
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TNIK SLC4A8 DSCAM CCT3 EHD3 LRIG2 PPP3CA DST PPP3CB PAK2 MFN2 MACF1 CTNNA2 HERC2 MAP4K4 PCNT	5.47e-05	963	183	16	28671696
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EML4 NELFA RALGAPB ARFGEF2 FAM91A1 TFIP11 URGCP USP19 IWS1 STK10 PACS1 PNPLA6 OXSR1 MAP4K4	6.66e-05	774	183	14	15302935
Pubmed	NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.	KLRC1 KLRC2	8.23e-05	3	183	2	32575403
Pubmed	Molecular cloning, characterization and expression of thyroid-stimulating hormone receptor in channel catfish.	CGB3 CGB1	8.23e-05	3	183	2	19523396
Pubmed	VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis.	FLT1 NRP1	8.23e-05	3	183	2	18284215
Pubmed	Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.	KLRC1 KLRC2	8.23e-05	3	183	2	37901227
Pubmed	Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.	PPP3CA PPP3CB	8.23e-05	3	183	2	12773574
Pubmed	Expression of the mouse Macf2 gene during inner ear development.	DST MACF1	8.23e-05	3	183	2	12399109
Pubmed	Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells.	KLRC1 KLRC2	8.23e-05	3	183	2	10092077
Pubmed	Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.	KLRC1 KLRC2	8.23e-05	3	183	2	25251060
Pubmed	Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs.	KLRC1 KLRC2	8.23e-05	3	183	2	15650876
Pubmed	Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population.	KLRC1 KLRC2	8.23e-05	3	183	2	12618865
Pubmed	Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency).	GALC GLB1	8.23e-05	3	183	2	10861297
Pubmed	Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.	PPP3CA PPP3CB	8.23e-05	3	183	2	2162844
Pubmed	Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).	PPP3CA PPP3CB	8.23e-05	3	183	2	8392375
Pubmed	Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion.	EHD2 EHD1	8.23e-05	3	183	2	21177873
Pubmed	Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling.	FLT1 FGFR1	8.23e-05	3	183	2	15817662
Pubmed	The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.	FLT1 FGFR1	8.23e-05	3	183	2	20103604
Pubmed	Molecular cloning of mouse NKG2A and C.	KLRC1 KLRC2	8.23e-05	3	183	2	10369936
Pubmed	Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells.	KLRC1 KLRC2	8.23e-05	3	183	2	10320637
Pubmed	HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.	KLRC1 KLRC2	8.23e-05	3	183	2	37264229
Pubmed	Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.	EHD3 EHD1	8.23e-05	3	183	2	25686250
Pubmed	VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.	MFN2 VCP	8.23e-05	3	183	2	23498974
Pubmed	Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.	SLC12A3 OXSR1	8.23e-05	3	183	2	18270262
Cytoband	1q21.1	NBPF8 NBPF11 NBPF9 NBPF10	1.14e-04	62	183	4	1q21.1
Cytoband	12p13	GPR162 KLRC1 KLRC2 KLRC3	1.29e-04	64	183	4	12p13
GeneFamily	Neuroblastoma breakpoint family	NBPF8 NBPF12 NBPF11 NBPF19 NBPF9 NBPF10 NBPF7P	1.20e-10	23	122	7	662
GeneFamily	CD molecules\|C-type lectin domain family\|Killer cell lectin like receptors	KLRC1 KLRC2 KLRC3	6.31e-05	12	122	3	621
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	FLT1 DSCAM LRIG2 HMCN2 PTPRF FGFR1 MYBPC2	1.11e-04	161	122	7	593
GeneFamily	Ubiquitin specific peptidases	USP13 USP11 USP43 USP19	5.53e-04	56	122	4	366
GeneFamily	EF-hand domain containing\|Plakins	DST MACF1	1.23e-03	8	122	2	939
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT1 MET FGFR1	2.47e-03	40	122	3	321
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	KLRC1 KLRC2 KLRC3	2.65e-03	41	122	3	1298
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP3CA PPP3CB	3.36e-03	13	122	2	693
GeneFamily	EF-hand domain containing	LPCAT1 EHD3 EHD2 DST EHD1 MACF1	3.72e-03	219	122	6	863
GeneFamily	Fibronectin type III domain containing	NPHS1 EPHA6 DSCAM PTPRF MYBPC2	4.61e-03	160	122	5	555
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	MAP3K14 TTYH2 NLRP1 EHD2 FZD7 MET DST FGFR1 TCF7L1	1.16e-07	195	182	9	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	EML4 MAP3K14 MET STK10 MACF1 FGFR1 DOT1L MAP4K4	1.29e-06	192	182	8	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DSCAM NLRP1 F8 EHD3 KLHL5 TLL1 TCF7L1	1.39e-06	194	182	8	74a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A EML4 SEC11C CCL1 KLRC1 KLRC2 IL9R	5.35e-06	165	182	7	004d793bf5bb6fb3b7bf38baf11b32d46375fe4d
ToppCell	droplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 ZC3H12A ADAMTS12 PROM2 NSG1 SLC49A3 MYO16	5.35e-06	165	182	7	622aca1d49bd8c917b131e4f4959d9dba411d22b
ToppCell	facs-Heart-LA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A UBASH3A HRH4 KLRC1 KLRC2 KLRC3 MYO16	6.03e-06	168	182	7	24d1e0a05cda09ee3b80208d75cb2b601023f3bf
ToppCell	facs-Heart-LA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A UBASH3A HRH4 KLRC1 KLRC2 KLRC3 MYO16	6.03e-06	168	182	7	b952af95a68888adedd03b1b60836d18524611ab
ToppCell	facs-Heart-LA-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A UBASH3A HRH4 KLRC1 KLRC2 KLRC3 MYO16	6.03e-06	168	182	7	16c3313c4186fa327d71215f8eebc31fc12ff1c0
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	USP13 FLT1 F8 TLL1 MACF1 FGFR1 ZNF160	9.46e-06	180	182	7	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, Lineage and Cell Type	FLT1 GAS2L3 MTMR8 ADCY2 NRP1 PTPRF GLB1	9.46e-06	180	182	7	be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 ALDH8A1 FAH LRRC19 SLC6A20 XYLB CA3	1.13e-05	185	182	7	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 ALDH8A1 FAH LRRC19 SLC6A20 XYLB CA3	1.13e-05	185	182	7	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	TNIK GGA2 EML4 NRP1 DST PNPLA6 LTA4H	1.34e-05	190	182	7	9fc763d65470ba8858b973689c4d4358faab7dd3
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	EPHA6 IRF6 ADCY2 MET PTPRF TLL1 DNAH5	1.39e-05	191	182	7	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ARFGEF2 SYNE3 MACF1 ETNK1 XYLB TMX3 POLQ	1.39e-05	191	182	7	9454f642c3621370fa23640b631301346b300950
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	USP13 FLT1 F8 KLHL5 TLL1 FGFR1 TCF7L1	1.39e-05	191	182	7	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPX1 PNPLA6 SEC11A HRH4 LTA4H CCNI KLRC1	1.44e-05	192	182	7	b9d6cf6068ffa104968f4944cbf8af6faa2b8942
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F8 EHD3 PTPRF MACF1 HERC2 CCNI VCP	1.44e-05	192	182	7	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	BAL-Control-Myeloid-MoAM-MoAM3\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	LPCAT1 ZC3H12A LILRB2 NR4A2 MET EHD1 DOT1L	1.49e-05	193	182	7	d81840e1322507552b7726bf7828309375162324
ToppCell	BAL-Control-Myeloid-MoAM-MoAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 ZC3H12A LILRB2 NR4A2 MET EHD1 DOT1L	1.49e-05	193	182	7	e4ca3a3c2704cdc52e6ac3f25f14debf74226c29
ToppCell	BAL-Control-Myeloid-MoAM-MoAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LPCAT1 ZC3H12A LILRB2 NR4A2 MET EHD1 DOT1L	1.49e-05	193	182	7	e54f8b6381b5a96758cff41ab12d6f60cfca29a9
ToppCell	BAL-Control-Myeloid-MoAM-MoAM3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 ZC3H12A LILRB2 NR4A2 MET EHD1 DOT1L	1.49e-05	193	182	7	837c61408462c519912ecf3b83fdc72cd85fe88f
ToppCell	Control-Myeloid-MoAM3\|Control / Disease group,lineage and cell class （2021.01.30）	LPCAT1 ZC3H12A LILRB2 NR4A2 MET EHD1 DOT1L	1.49e-05	193	182	7	97d2f12be43fc26efa84ac4c6119132928a123de
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	TNIK USP13 LPCAT1 EML4 MACF1 FGFR1 TCF7L1	1.54e-05	194	182	7	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	EPHA6 IRF6 ADCY2 MET PTPRF TLL1 DNAH5	1.54e-05	194	182	7	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, condition lineage and cell class	TTYH2 NR4A2 KLHL5 DST POLQ HPS5 TCF7L1	1.70e-05	197	182	7	e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA4 EHD2 DST TMX3 CCNI MAP4K4 VCP	1.75e-05	198	182	7	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA4 EHD2 DST TMX3 CCNI MAP4K4 VCP	1.75e-05	198	182	7	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA4 EHD2 DST TMX3 CCNI MAP4K4 VCP	1.81e-05	199	182	7	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 GPX1 ALDH8A1 FAH HPX CA3	5.66e-05	163	182	6	61b4e38d7bbbb031100670928e6fd4f7ea23814f
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 GPX1 ALDH8A1 FAH HPX CA3	5.66e-05	163	182	6	0b4d234bdd57d5e991f68942333ca89f70ea28df
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 GPX1 ALDH8A1 FAH HPX CA3	5.66e-05	163	182	6	cc728796e52d0e6cc1198e0732370c62380e951d
ToppCell	facs-GAT-Fat-24m-Lymphocytic-NK_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNIK NR4A2 C16orf96 KLRC1 KLRC2 KLRC3	5.66e-05	163	182	6	e58863a462cc504bced627f004a47890ee2307ce
ToppCell	facs-BAT-Fat-18m-Lymphocytic-NK_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 UBASH3A LTA4H KLRC1 KLRC2 KLRC3	5.86e-05	164	182	6	ab9c17f86b98e1a4d5db1bd3086edab1320ebda8
ToppCell	COVID-19_Mild-PLT_0\|COVID-19_Mild / Disease Group and Platelet Clusters	ZC3H12A GPX1 ALPK1 SYNE3 GOLPH3L MACF1	6.06e-05	165	182	6	083a14d3b0162cee4e79f7398b8fb739582b39ff
ToppCell	facs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS2L3 TTYH2 GPR37L1 F8 LRIG2 TCF7L1	7.62e-05	172	182	6	2f1673fcb2356684d60871debb0f159aec553a1c
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS2L3 TTYH2 GPR37L1 F8 LRIG2 TCF7L1	7.62e-05	172	182	6	b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GAS2L3 ENTHD1 NLRP1 SPAG5 VWA3B SLC49A3	8.12e-05	174	182	6	65147b0f8c2ccadd5685430d31081520c157536a
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FLT1 GPX1 KLHL5 DAPP1 PAK2 FGFR1	8.65e-05	176	182	6	56c055488e34605d32562571a2fee621b47c9441
ToppCell	facs-Aorta\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 F8 NRP1 EHD3 DNAH5 CA3	8.65e-05	176	182	6	0b3491451be02c18a16cdb875645be47eb867a7f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DSCAM NLRP1 F8 EHD3 HMCN2	8.65e-05	176	182	6	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHX2 PLB1 SLC4A8 DSCAM IRF6 GPR162	8.93e-05	177	182	6	4672cc75225a4a23b298afa8ce439628262519db
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-A\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TEKT5 MMP24 PROM2 PHF21B AHNAK2	9.69e-05	112	182	5	d21cfcb04a27cc9fb74e0c2afa8a8cdfb886ae21
ToppCell	10x3'2.3-week_17-19-Lymphocytic_NK-T_NK-CD56_bright_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	EML4 NR4A2 MACF1 KLRC1 KLRC2 KLRC3	9.79e-05	180	182	6	ddbab26b05f057bd78b78773381cd447bd2e2726
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_straight_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 GPX1 ALDH8A1 FAH SLC6A20 CA3	9.79e-05	180	182	6	b34d933cdabf692f02eaaf65c2aaca1fb9510627
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHA6 USP43 NBPF19 MET PPP3CA PRKG2	1.01e-04	181	182	6	57994ff4ecffb15653aee00644d9f887f5e3461d
ToppCell	facs-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA4 NRP1 EHD3 DST HPX CA3	1.04e-04	182	182	6	4c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DSCAM GPR37L1 FGFR1 KLRC2 KLRC3 AGAP1	1.04e-04	182	182	6	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DSCAM GPR37L1 FGFR1 KLRC2 KLRC3 AGAP1	1.04e-04	182	182	6	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH8A1 GCSH FAH LRRC19 SLC6A20 XYLB	1.10e-04	184	182	6	3d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH8A1 GCSH FAH LRRC19 SLC6A20 XYLB	1.10e-04	184	182	6	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS2L3 CORO2A NCOA4 NUP205 POLQ IMPG2	1.10e-04	184	182	6	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GAS2L3 CORO2A NCOA4 NUP205 AGAP1 IMPG2	1.14e-04	185	182	6	b4af9ae4c358b48357cb135b740266e1652d886a
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TFIP11 UBASH3A KLRC1 KLRC2 IL9R	1.14e-04	116	182	5	f7f0cd61723c94586504b656a8d4e098e98d8e23
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NR4A2 IRF6 FZD7 PPP3CA KLRC1 AGAP1	1.17e-04	186	182	6	fc0b488c201a32d829047b58460297df2818b45d
ToppCell	mild_COVID-19_(asymptomatic)-gd_T\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TNIK NR4A2 PRMT2 KLRC1 KLRC2 KLRC3	1.17e-04	186	182	6	5fa3ed834898aa06aae15a8ade7ab93a6e4744f8
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNIK GALC NR4A2 ENTHD1 MYO16 IL9R	1.21e-04	187	182	6	bdcef4f3e093c3646b639a189bbe93d6f4c40f3c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNIK GALC NR4A2 ENTHD1 MYO16 IL9R	1.21e-04	187	182	6	0f7a42c55997e34a0d20e492e16b03e91e965335
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNIK GALC NR4A2 ENTHD1 MYO16 IL9R	1.21e-04	187	182	6	064730fa72f8637c3db3fc34d2e363d2b9a38f1d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNIK GALC NR4A2 ENTHD1 MYO16 IL9R	1.21e-04	187	182	6	09348f1e8bbbca8dca885461937b9b1dd248b034
ToppCell	facs-Skin-Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGA2 DDX1 EHD2 FZD7 CCNI VCP	1.28e-04	189	182	6	adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	LPCAT1 FLT1 LILRB2 NBPF19 EHD1 MAP4K4	1.28e-04	189	182	6	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	(3)_DC_activated\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MAP3K14 TTYH2 ENTHD1 MMP24 SLC12A3 DAPP1	1.28e-04	189	182	6	e977838793fc0eb1499e81018e33e4ccb4a5f0c5
ToppCell	5'-Adult-LargeIntestine-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A1BG SEC11C IGKV3D-15 KLRC2 KLRC3 IGKV3-15	1.35e-04	191	182	6	d1d30279ed4612b4f62c225d9eabf0b8a7a09d11
ToppCell	(04)_Pre-ciliated\|World / shred by cell type and Timepoint	USP11 USP43 SPAG5 NUP205 CABCOCO1 PCNT	1.35e-04	191	182	6	37cf121e6e80760c8519075b7845b9029958a988
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK TTC28 NRP1 MET TLL1 AGAP1	1.35e-04	191	182	6	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK NSG1 ULBP1 MACF1 KLRC1 AGAP1	1.39e-04	192	182	6	ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	TNIK EML4 NLRP1 SLC20A1 MACF1 HERC1	1.39e-04	192	182	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK NSG1 ULBP1 MACF1 KLRC1 AGAP1	1.39e-04	192	182	6	58a7829b411b02b422ef75e2277a868969cc23e8
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	LPCAT1 MET PTPRF DNAH5 TCF7L1 AGAP1	1.39e-04	192	182	6	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	343B-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZC3H12A NR4A2 NBPF19 EHD1 OXSR1 MAP4K4	1.43e-04	193	182	6	24c06b0461894fe9f68bf26507d7a708468237c2
ToppCell	Control-Myeloid-MoAM5,_CCL3L1\|Control / Condition, Lineage and Cell class	LPCAT1 ZC3H12A LILRB2 NBPF19 EHD1 DOT1L	1.47e-04	194	182	6	a1dd264822de83a0ffaf89ca4707c6a76809359e
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	TNIK GANC TNPO2 MAP3K14 IRF6 RTN2	1.47e-04	194	182	6	4c40d6b50675eae52c419d69e719a9223df02ae3
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	USP43 IRF6 ADCY2 MET TLL1 DNAH5	1.47e-04	194	182	6	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	EPHA6 USP43 SEC11C IRF6 PTPRF TLL1	1.47e-04	194	182	6	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-NK_CD56bright_CD16-\|bone_marrow / Manually curated celltypes from each tissue	LPCAT1 ZC3H12A USP43 KLRC1 KLRC2 KLRC3	1.47e-04	194	182	6	5c58a2d1dd3c8ff77ce44d473239685e6b020909
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 NLRP1 F8 EHD3 TLL1 TCF7L1	1.47e-04	194	182	6	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TNIK TTC28 ADCY2 NRP1 ADAMTS12 DST	1.47e-04	194	182	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Control-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	LPCAT1 FLT1 LILRB2 STK10 OXSR1 MAP4K4	1.47e-04	194	182	6	f852f5258617a66a4fbd56d64c7b47272e7b8b60
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|356C / Donor, Lineage, Cell class and subclass (all cells)	TNIK GANC TNPO2 MAP3K14 IRF6 RTN2	1.47e-04	194	182	6	99a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	EPHA6 IRF6 ADCY2 MET PTPRF TLL1	1.47e-04	194	182	6	b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM91A1 SEC11C DST MACF1 HERC2 CCNI	1.52e-04	195	182	6	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	USP13 FLT1 F8 TLL1 MACF1 FGFR1	1.52e-04	195	182	6	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	343B-Myeloid-Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZC3H12A LILRB2 NR4A2 NBPF19 EHD1 OXSR1	1.52e-04	195	182	6	ff87a33f9a48765bfa9408f686985feefeff2adf
ToppCell	ILEUM-inflamed-(6)_ILC3\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EML4 MMP24 DST SEC11A LTA4H KLRC1	1.52e-04	195	182	6	c6968da7d2b60c2163e1ff0ffa41340e1ec1d2ed
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPCAT1 FLT1 F8 NRP1 EHD3 MACF1	1.52e-04	195	182	6	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	(2)_5-FU\|World / Stress and Cell class	NRP1 EHD3 EHD2 FAH NSG1 CA3	1.52e-04	195	182	6	e5b1d96fafeb2f3b1f4cdf6b2c9eddef36bca7ff
ToppCell	343B-Myeloid-Monocyte-CD14+_Monocyte\|343B / Donor, Lineage, Cell class and subclass (all cells)	ZC3H12A LILRB2 NR4A2 NBPF19 EHD1 OXSR1	1.52e-04	195	182	6	b5ee368c97113432fc8fe742654cd538558f327c
ToppCell	normal_Lymph_Node-T/NK_cells-NK\|normal_Lymph_Node / Location, Cell class and cell subclass	ZC3H12A NR4A2 USP43 KLRC1 KLRC2 KLRC3	1.56e-04	196	182	6	00ab4a1547752d419aa720b39b94a4ab2ede963a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 NLRP1 F8 KLHL5 TLL1 TCF7L1	1.56e-04	196	182	6	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	USP13 FLT1 F8 FGFR1 HERC1 ZNF160	1.56e-04	196	182	6	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 NLRP1 F8 KLHL5 TLL1 TCF7L1	1.56e-04	196	182	6	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	USP13 FLT1 NLRP1 F8 TLL1 TCF7L1	1.56e-04	196	182	6	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	(3)_MNP-(3)_Monocyte\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	LPCAT1 ZC3H12A LILRB2 NR4A2 NBPF19 EHD1	1.56e-04	196	182	6	83af2eb1c28dfe7678d972be1d6d358c4a94731d
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LPCAT1 SEC11C DNTTIP1 MET PTPRF LTA4H	1.60e-04	197	182	6	1638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	LPCAT1 PLB1 NR4A2 PTPRF LTA4H DNAH5	1.60e-04	197	182	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LILRB2 STK10 EHD1 NBPF10 ULBP1 IMPG2	1.60e-04	197	182	6	4a6eff66a17c5e89bda61d887b736f5c62b93bd7
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TNIK NSG1 MACF1 KLRC1 KLRC2 AGAP1	1.65e-04	198	182	6	a1b310274aa9b3d2aa1fe9488d67422bf4ac81d2
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNIK ZC3H12A PRMT2 MACF1 KLRC1 AGAP1	1.65e-04	198	182	6	2fdb92b198ba24e326e90479fd024400d956fb32
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TNIK NSG1 MACF1 KLRC1 KLRC2 AGAP1	1.65e-04	198	182	6	a781fd35a7cda8b7760c2e3ddccaac7aac26c979
Disease	mean corpuscular hemoglobin concentration	CCT3 TTC28 ALDH8A1 ARFGEF2 GON4L ENTHD1 C16orf96 NCOA4 NEB FOCAD PAK2 MACF1 OXSR1 DOT1L CCNI KLRC2 MYO16 CA3 CAPN15 AGAP1 IMPG2	1.71e-06	1105	170	21	EFO_0004528
Disease	gestational diabetes (implicated_via_orthology)	GPX1 MET	3.30e-05	2	170	2	DOID:11714 (implicated_via_orthology)
Disease	vascular dementia (biomarker_via_orthology)	FLT1 GPX1 FGFR1	6.53e-05	14	170	3	DOID:8725 (biomarker_via_orthology)
Disease	primary biliary cholangitis (implicated_via_orthology)	ZC3H12A MAP3K14	1.96e-04	4	170	2	DOID:12236 (implicated_via_orthology)
Disease	Hereditary Autosomal Dominant Spastic Paraplegia	PNPLA6 MFN2	3.26e-04	5	170	2	C0751602
Disease	HMSN Type V	PNPLA6 MFN2	3.26e-04	5	170	2	C4721916
Disease	glucagon measurement, glucose tolerance test	MACF1 HERC1	4.88e-04	6	170	2	EFO_0004307, EFO_0008463
Disease	Lissencephaly	MACF1 CTNNA2	4.88e-04	6	170	2	C0266463
Disease	Schizophrenia	A1BG TNIK EPHX2 NR4A2 TEKT5 ADAMTS12 MET PAK2 FGFR1 OXSR1 CTNNA2 ZKSCAN4 MYO16 PCNT	6.26e-04	883	170	14	C0036341
Disease	myeloid neoplasm (is_implicated_in)	GPX1 FGFR1	6.80e-04	7	170	2	DOID:0070004 (is_implicated_in)
Disease	electroencephalogram measurement	FOCAD PRKG2 MYO16 PHF21B	8.94e-04	74	170	4	EFO_0004357
Disease	focal segmental glomerulosclerosis (is_marker_for)	PPP3CA PPP3CB	9.03e-04	8	170	2	DOID:1312 (is_marker_for)
Disease	cerebrospinal fluid clusterin measurement	DST TLL1 CTNNA2	1.07e-03	35	170	3	EFO_0007657
Disease	diet measurement	SLC4A8 DSCAM NR4A2 ARFGEF2 ALPK1 MMP24 DST PTPRF TLL1 ZNF432 CTNNA2 CABCOCO1 DNAH5 MYO16 AGAP1	1.14e-03	1049	170	15	EFO_0008111
Disease	cerebral palsy (implicated_via_orthology)	AGAP11 AGAP1	1.44e-03	10	170	2	DOID:1969 (implicated_via_orthology)
Disease	placenta growth factor measurement	FLT1 NRP1	1.75e-03	11	170	2	EFO_0010626
Disease	Oligodontia	IRF6 FGFR1	2.10e-03	12	170	2	C4082304
Disease	prediabetes syndrome (biomarker_via_orthology)	SLC4A8 MFN2	2.10e-03	12	170	2	DOID:11716 (biomarker_via_orthology)
Disease	dimethylglycine measurement	FAH SLC6A20 CACNA1G	2.38e-03	46	170	3	EFO_0010476
Disease	liver cirrhosis (implicated_via_orthology)	FOCAD FAH	2.47e-03	13	170	2	DOID:5082 (implicated_via_orthology)
Disease	actinic keratosis	MMP24 HERC2	2.87e-03	14	170	2	EFO_0002496
Disease	Hypodontia	IRF6 FGFR1	2.87e-03	14	170	2	C0020608
Disease	cleft lip (is_implicated_in)	IRF6 FGFR1	3.30e-03	15	170	2	DOID:9296 (is_implicated_in)
Disease	anemia (implicated_via_orthology)	SLC4A8 GPX1	3.30e-03	15	170	2	DOID:2355 (implicated_via_orthology)
Disease	response to irinotecan	SYNE3 OXSR1	3.30e-03	15	170	2	EFO_0004829
Disease	Spondyloepiphyseal Dysplasia	FLT1 GLB1	3.76e-03	16	170	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLT1 GLB1	3.76e-03	16	170	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	FLT1 GLB1	3.76e-03	16	170	2	C4551479
Disease	Schwartz-Jampel Syndrome	FLT1 GLB1	3.76e-03	16	170	2	C0036391
Disease	Melnick-Needles Syndrome	FLT1 GLB1	3.76e-03	16	170	2	C0025237
Disease	Hepatomegaly	A1BG DSCAM CABCOCO1	3.76e-03	54	170	3	C0019209
Disease	Van Buchem disease	FLT1 GLB1	4.24e-03	17	170	2	C0432272
Disease	Drug habituation	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C0013170
Disease	Drug abuse	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C0013146
Disease	Prescription Drug Abuse	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C4316881
Disease	Substance-Related Disorders	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C0236969
Disease	Drug Use Disorders	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C0013222
Disease	Drug Dependence	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C1510472
Disease	Substance Dependence	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C0038580
Disease	Substance Use Disorders	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	DSCAM EIPR1 DDX1 PACS1	4.48e-03	115	170	4	C0029231
Disease	Substance abuse problem	DSCAM EIPR1 DDX1 PACS1	4.62e-03	116	170	4	C0740858
Disease	response to clozapine	FZD7 CTNNA2	4.75e-03	18	170	2	GO_0097338
Disease	FEV/FEC ratio	DCHS2 FLT1 EML4 SEC11C NEB TEKT5 ADCY2 MET MINDY3 DST FGFR1 HERC1 DNAH5 TCF7L1 MYO16	5.08e-03	1228	170	15	EFO_0004713
Disease	skin sensitivity to sun	ADAMTS12 HERC2	5.29e-03	19	170	2	EFO_0004795
Disease	Osteochondrodysplasias	FLT1 GLB1	5.29e-03	19	170	2	C0029422
Disease	Dyschondroplasias	FLT1 GLB1	5.29e-03	19	170	2	C0013366
Disease	response to methotrexate, neurotoxicity	PNPLA6 MACF1	5.29e-03	19	170	2	EFO_0011057, GO_0031427
Disease	Arsenic Induced Polyneuropathy	TNIK USP13 NR4A2	5.54e-03	62	170	3	C0751852
Disease	Arsenic Encephalopathy	TNIK USP13 NR4A2	5.54e-03	62	170	3	C0751851
Disease	Arsenic Poisoning	TNIK USP13 NR4A2	5.54e-03	62	170	3	C0311375
Disease	Arsenic Poisoning, Inorganic	TNIK USP13 NR4A2	5.54e-03	62	170	3	C0274861
Disease	Nervous System, Organic Arsenic Poisoning	TNIK USP13 NR4A2	5.54e-03	62	170	3	C0274862

Protein segments in the cluster

Peptide	Gene	Start	Entry
IVWLLLKEPMTVSSD	CA3	206	P07451
LLLAGMWPEDVDSKS	CCL1	11	P22362
IAKPSELTSVTAWML	ALDH8A1	176	Q9H2A2
LPEKVDVLVSEWMGT	PRMT2	201	P55345
ESIKWLGEVMAEIGP	CABCOCO1	31	Q8IVU9
DDWPVELRKVMSSIG	AGAP11	386	Q8TF27
LDDWPVELIKVMSSI	AGAP1	666	Q9UPQ3
WTLEELSKAVKMPVA	ANAPC2	676	Q9UJX6
VGDPLEKAMLTAVDW	ATP13A1	586	Q9HD20
LMWALGKVVGTPEVL	EHD2	236	Q9NZN4
TALMTDPKLITWSPV	GPX1	141	P07203
KLPEQLSEKSEWMTT	ARFGEF2	1386	Q9Y6D5
MEKLIPDWLSLTIEL	CCNI	211	Q14094
LLLSMGGTWASKEPL	CGB1	41	A6NKQ9
SPAGAKWTETEIEML	BAP18	36	Q8IXM2
MRVVELSPLKGSVSW	DOT1L	291	Q8TEK3
EKLMATGPTNESVWI	ADAMTS12	781	P58397
SSWVSLPGKMRKEIL	ALPK1	956	Q96QP1
EEMKFLSIISPSSWI	KLRC1	161	P26715
RWAGVEDPKVMITTS	IMP4	76	Q96G21
GVMSAIKEWLSPLPD	IWS1	611	Q96ST2
KTWTLELSPELASMT	NUP205	156	Q92621
DELWLVMKLLSGGSV	OXSR1	86	O95747
SKWEDAIPLALKMAT	LTA4H	546	P09960
LSMAPVSWITPGLKT	A1BG	121	P04217
EPVDTDLIWAKMLSS	CAPN15	671	O75808
LPLKIHGWKSTEDLM	ENTHD1	226	Q8IYW4
PVTGVLDQTTIEWMK	MMP24	121	Q9Y5R2
LSSTTVPKMLAILWL	OR52D1	76	Q9H346
KLLLLTPEAGTMVTW	NPHS1	136	O60500
AREWAKSMTSVLEPV	PNPLA6	1036	Q8IY17
TKDVVLQWGEMPTSV	MAP4K4	1151	O95819
KELMELVWGTKSSPG	MINDY3	6	Q9H8M7
MNGLIIFITSWTDPK	OR10AD1	41	Q8NGE0
MEGNKTWITDITLPR	OR2A14	1	Q96R47
IVMKAESRDIPIWGT	LPCAT1	151	Q8NF37
SDPWVLMVADILKSF	NELFA	86	Q9H3P2
LKSDSAPPWMVLAVL	GPR162	296	Q16538
EMRESGWKLIDPISD	MTMR8	121	Q96EF0
WEEKMKEPLSASTLA	MYO16	311	Q9Y6X6
GALSSPQWITLLMKV	HERC2	2041	O95714
TVQDPLMELKLIWDS	DST	6346	Q03001
VSWMKDGEPLLSQSL	HMCN2	3446	Q8NDA2
KSTLDPQKMLLSWDG	FAM91A1	321	Q658Y4
KDTLISMKWDPTGHI	HERC1	3626	Q15751
SPSVWDTFIEGLKEM	HPS5	801	Q9UPZ3
EMGGLPAWLLEKESI	GLB1	131	P16278
PTEKSLLMLFLWAVS	GJD4	191	Q96KN9
SPEMWSEAIKILKGE	DDX1	481	Q92499
SLSTSIVPKMLDIFW	OR52A4P	76	A6NMU1
WEALVKPGDLMPATT	NLRP1	1346	Q9C000
EWSNLKISIPMLLTL	GANC	591	Q8TET4
TPVLEEASSTGMWIK	MACF1	1356	O94854
WSELSDPLVLVMTGA	LILRB2	106	Q8N423
VSPWMSVLSEEKLSE	NSG1	161	P42857
LELWLNKATDPSMSE	GGA2	26	Q9UJY4
DGWLIKMTLSNPSEL	GCSH	141	P23434
VFETVEMLPSKAGIW	F8	2001	P00451
LLLWLPDTTGEIVMT	IGKV3D-15	11	A0A087WSY6
GWLLESGRPKEMVST	INSL4	56	Q14641
IKMEGVEPNSLWSLI	KLHL5	261	Q96PQ7
VGMLDLSSWSSPEVL	PCNT	2216	O95613
VWEPMGDGKKIISLA	EIPR1	141	Q53HC9
FQGEKLLSSIPMWTT	PRKG2	216	Q13237
MLWDKVLPSGIGHTT	MFN2	116	O95140
PMELAALEKIKSTWI	PACS1	431	Q6VY07
TPETEAMWKTLSKLA	IFT172	621	Q9UG01
DATPEWLSLISIMEK	DCHS2	3066	Q6V1P9
GLATTIMPKILAILW	OR56B2P	81	Q8NGI1
KKPLSTPSMVTEDWL	NCOA4	376	Q13772
IKPATWETGISMRFE	NRP1	406	O14786
GPKVDIWSLGIMAIE	PAK2	421	Q13177
WAVPAVKTITILAMG	FZD7	386	O75084
PGIWKDLKTMGSVSL	ADCY2	796	Q08462
TRLMKGEITLSQWIP	EPHX2	51	P34913
MTSATSPIILKWDPK	CTNNA2	1	P26232
SLLIQGSLEWELKLM	CACNA1G	1936	O43497
LLLSMGGTWASKEPL	CGB3	11	P0DN86
TIPKTEDMVLWSGLH	C16orf96	211	A6NNT2
ATWSIIMDSVVPSDK	FGFR1	211	P11362
TLLPMQEDLSIWLSG	GAS2L3	46	Q86XJ1
KLAVIWVGSMTLAVP	GPR37L1	251	O60883
SIAAEWKMIEPESVG	POLQ	2361	O75417
EDGWRSSSLLEEKMP	CORO2A	436	Q92828
LLEGKMSTQDPSDLW	DAPP1	6	Q9UN19
GTKPSATEMIWAVLA	GOLPH3L	266	Q9H4A5
DSSKPIVRESWMTEL	GPALPP1	181	Q8IXQ4
SVPELQETMEKLTWL	GON4L	1486	Q3T8J9
MAVPTIIGLSLWKEF	DPY19L4	531	Q7Z388
LLLWLPDTTGEIVMT	IGKV3-15	11	P01624
GGVMLIWSKTTVEPT	EML4	476	Q9HC35
SMLELSWKGTKPIDL	FAH	361	P16930
TWMKEILSNLGSPVV	ETNK1	291	Q9HBU6
ESSSVLLLEMWKPRV	FAM237A	51	A0A1B0GTK4
TSGMLNDKSLWTDIP	GALC	641	P54803
LMWSLGKIINTPEVV	EHD1	236	Q9H4M9
WSLPFVGEKVTEMLV	PPP3CB	361	P16298
IKIVMSWFVSPLLSG	SLC20A1	156	Q8WUM9
MVEPFLGTWKLVSSE	FABP9	1	Q0Z7S8
TWSLPFVGEKVTEML	PPP3CA	351	Q08209
PDITWGMLKKTTQEA	PPHLN1	406	Q8NEY8
WLFSIMESPKEALSA	FOCAD	1756	Q5VW36
DLLDVSSGSQWKPML	DNAH5	4171	Q8TE73
WPLSMILLSDKIQSS	LRRC19	11	Q9H756
AAAMKTSVLLSWEVP	PTPRF	1021	P10586
TLSKEESGMWEPLPL	MAP3K14	731	Q99558
PLFVTVGDWLDSIKM	EPHA6	961	Q9UF33
LWISSLPMTDLDIKF	IRF6	216	O14896
LLSILWMLKSSPGAT	MUC3B	6	Q9H195
TKMLGAEWSKLQPTE	HMG20B	101	Q9P0W2
TGSMEIIRGWAEKIP	NR4A2	411	P43354
FSGTVTTPWMKDIVL	DSCAM	1291	O60469
DLATGTMKERSWPAV	HPX	171	P02790
VNGPMILVSESWKDE	HRH4	146	Q9H3N8
TGAKLPVKWMALESL	MET	1241	P08581
LGTAMEWLKTSLLLA	RTN2	271	O75298
SPLAWLEKGVNTSVM	SPAG5	341	Q96R06
MIWKGLIVLTGSESP	SEC11C	46	Q9BY50
MEVDGVPTLILSKEW	SULT1C3	21	Q6IMI6
DKLPEVLTSTDSRMW	TLL1	426	O43897
LVEAQGWLVMEKSSP	SYNE3	706	Q6ZMZ3
GPWSSEKAEMNILEI	NBPF7P	26	P0C2Y1
GPWSSEKAEMNILEI	NBPF8	6	Q3BBV2
GPWSSEKAEMNILEI	NBPF9	6	P0DPF3
GPWSSEKAEMNILEI	NBPF10	6	Q6P3W6
GPWSSEKAEMNILEI	NBPF11	6	Q86T75
GPWSSEKAEMNILEI	NBPF12	6	Q5TAG4
GPWSSEKAEMNILEI	NBPF19	6	A0A087WUL8
MKFLASILPSSWIGV	KLRC2	161	P26717
LELAKEGDWMTLPGI	PNLDC1	161	Q8NA58
QSETPLEKVPWLSVM	SIMC1	381	Q8NDZ2
WLSVMETPARKEISL	SIMC1	391	Q8NDZ2
GMEKIDGTISVPETW	TEKT5	281	Q96M29
TLVDMKELGIWEPLA	CCT3	486	P49368
MTSLGKEWDITTLNP	SPATA31E1	391	Q6ZUB1
EMKFLASILPSSWIG	KLRC3	161	Q07444
ISDEMPKTTVWKALS	SLC4A8	1066	Q2Y0W8
GMLLPSVLSKARSWT	IL9R	506	Q01113
VKPDMQTLWTILPES	IMPG2	766	Q9BZV3
WTNMLEPLGSKTETL	PLB1	1016	Q6P1J6
LMWSLGKIVNTPEVI	EHD3	236	Q9NZN3
KVMWAGVSPLLIVSL	SLC6A20	506	Q9NP91
ESLLGLWKGMSPSIV	SLC25A38	81	Q96DW6
KMDTSTDPVRVLSWL	AKAP3	31	O75969
LWEDSVLTVKFPKLM	AHNAK2	5376	Q8IVF2
DPLDWTVSLLLMAGL	SLC49A3	416	Q6UXD7
PIWNEVGLEMKSIGS	TMX3	61	Q96JJ7
STLSMPVRWVTGLLK	URGCP	666	Q8TCY9
ITKDVVLQWGEMPTS	TNIK	1271	Q9UKE5
KKVPMLTWPSLLVEA	USP19	191	O94966
QGMVKLSLWTLPDIL	USP43	571	Q70EL4
WIGTKERTEKLPMGS	UBFD1	241	O14562
IISMLEEGKEPWTVK	ZNF160	56	Q9HCG1
GEKPVLEASPTMSLW	ZC3H12A	6	Q5D1E8
LKKDEGVPWTGMLAI	PHF21B	401	Q96EK2
SIKGPELLTMWFGES	VCP	541	P55072
LEELKSFVLPSWMVE	DNTTIP1	291	Q9H147
MKWPLLDVPSSATVK	TCF7L1	151	Q9HCS4
SIEAMPETLLSLWGL	PROM2	186	Q8N271
SGLPVWREVTMELTK	TTYH2	186	Q9BSA4
LITTIASKGELQMWP	TNPO2	111	O14787
KESMPSWGISKEELF	ZNF514	81	Q96K75
WSLGITLIEMAQIEP	STK10	221	O94804
KDGLTVTSPVLMWVQ	XYLB	56	O75191
IPKGTLMAIFWTTIS	SLC12A3	371	P55017
WKGLMVITGSESPIV	SEC11A	36	P67812
LKMSWFLPTVLDTGQ	TMEM168	676	Q9H0V1
TDWIMALVLPKDSIP	RALGAPB	91	Q86X10
MLKKPSSLEQWEILG	nan	1	Q0VFX4
WKLSALVLTPSMDGN	TTC28	1551	Q96AY4
LKMEDVALTLTPGWT	ZKSCAN4	221	Q969J2
ALSKLERGEEPWTME	ZNF432	56	O94892
KAMATTLSPWSLLII	ULBP1	221	Q9BZM6
LNWPISLKELSMLES	VWA3B	971	Q502W6
MDWKLEGSTQKVESP	TRMT10B	1	Q6PF06
WSLPEMVSKESERLS	FLT1	61	P17948
LIIMETRKKDGTWPS	USP11	271	P51784
ETPSKTKWSLLMEDI	ZNF317	131	Q96PQ6
EKTWVPTSLQSLIDM	TFIP11	821	Q9UBB9
EWEVIQESGTKLKPM	USP13	316	Q92995
KWEAGKTTPTLMSLE	UBASH3A	516	P57075
VWLGLSISKPNMISL	ZNF527	51	Q8NB42
DSPMSTVWRKDSEIL	LRIG2	526	O94898
MKETTFAELISLDWP	NLRP13	276	Q86W25
LMVEISDPDLTLKWF	MYBPC2	276	Q14324
WKTKFSSPVDMLSIL	NEB	3811	P20929
VKSKEMGELVNTPSW	NEUROD4	6	Q9HD90