Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SCN10A SLC24A5 TRPM4 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

2.55e-103434611GO:0005261
GeneOntologyMolecularFunctiontransporter activity

SCN10A SLC24A5 ABCB11 TRPM4 SLC5A12 CHRNA9 ATAD1 ABCD2 NALCN SLCO6A1 ANO6 NDUFS2 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

1.54e-0912894617GO:0005215
GeneOntologyMolecularFunctionsodium channel activity

SCN10A TRPM4 NALCN SCN2A TRPM2 SCN8A

2.00e-0952466GO:0005272
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SCN10A SLC24A5 TRPM4 SLC5A12 CHRNA9 NALCN ANO6 NDUFS2 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

2.00e-096644613GO:0008324
GeneOntologyMolecularFunctiontransmembrane transporter activity

SCN10A SLC24A5 ABCB11 TRPM4 SLC5A12 CHRNA9 ABCD2 NALCN SLCO6A1 ANO6 NDUFS2 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

3.68e-0911804616GO:0022857
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN10A SLC24A5 TRPM4 SLC5A12 NALCN SCN2A TRPM2 SCN8A

4.85e-09171468GO:0015081
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SCN10A SLC24A5 TRPM4 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

5.43e-094594611GO:0005216
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SCN10A SLC24A5 TRPM4 SLC5A12 CHRNA9 NALCN ANO6 NDUFS2 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

1.68e-087934613GO:0015075
GeneOntologyMolecularFunctionchannel activity

SCN10A SLC24A5 TRPM4 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

2.17e-085254611GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SCN10A SLC24A5 TRPM4 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

2.21e-085264611GO:0022803
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SCN10A SLC24A5 TRPM4 SLC5A12 CHRNA9 NALCN SCN2A RYR3 TRPM2 SCN8A

8.19e-084654610GO:0046873
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SCN10A SLC24A5 TRPM4 SLC5A12 CHRNA9 NALCN ANO6 NDUFS2 SCN2A RYR3 TRPM2 SCN8A

9.74e-087584612GO:0015318
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SCN10A SLC24A5 TRPM4 SLC5A12 CHRNA9 NALCN NDUFS2 SCN2A RYR3 TRPM2 SCN8A

1.32e-076274611GO:0022890
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN10A NALCN SCN2A SCN8A

3.55e-0726464GO:0005248
GeneOntologyMolecularFunctiongated channel activity

SCN10A TRPM4 CHRNA9 ANO6 PIEZO1 SCN2A RYR3 TRPM2

8.45e-07334468GO:0022836
GeneOntologyMolecularFunctioncalcium channel activity

SLC24A5 TRPM4 CHRNA9 RYR3 TRPM2

1.15e-05129465GO:0005262
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

TRPM4 CHRNA9 ANO6 RYR3 TRPM2

1.72e-05140465GO:0099094
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

SLC24A5 TRPM4 CHRNA9 RYR3 TRPM2

2.47e-05151465GO:0015085
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPM4 RYR3 TRPM2

4.92e-0531463GO:0099604
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

TRPM4 CHRNA9 ANO6 RYR3 TRPM2

7.96e-05193465GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

TRPM4 CHRNA9 ANO6 RYR3 TRPM2

8.77e-05197465GO:0022834
GeneOntologyMolecularFunctionsodium ion binding

SCN2A SCN8A

4.64e-0414462GO:0031402
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN10A SCN2A

6.91e-0417462GO:0099508
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC24A5 ABCB11 SLC5A12 ABCD2 SLCO6A1 NDUFS2

7.50e-04477466GO:0022804
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR3 TRPM2

7.76e-0418462GO:0015278
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

SCN10A TRPM4 ANO6 SCN2A

8.08e-04182464GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

SCN10A TRPM4 ANO6 SCN2A

8.42e-04184464GO:0022832
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

ABCB11 SLC5A12 ABCD2

1.17e-0390463GO:0008028
GeneOntologyMolecularFunctionalkali metal ion binding

SCN2A SCN8A

1.63e-0326462GO:0031420
GeneOntologyMolecularFunctioncalcium-activated cation channel activity

TRPM4 ANO6

1.76e-0327462GO:0005227
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

TRPM4 ANO6

2.31e-0331462GO:0022839
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR3 TRPM2

2.62e-0333462GO:0005217
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCB11 SLC5A12 ABCD2 SLCO6A1

4.57e-03293464GO:0008514
GeneOntologyMolecularFunctionABC-type transporter activity

ABCB11 ABCD2

5.70e-0349462GO:0140359
GeneOntologyMolecularFunctionubiquitin protein ligase binding

TGFBR1 HM13 NDUFS2 RTN4

7.45e-03337464GO:0031625
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCB11 ABCD2 NDUFS2

7.98e-03178463GO:0015399
GeneOntologyMolecularFunctionubiquitin-like protein ligase binding

TGFBR1 HM13 NDUFS2 RTN4

9.17e-03358464GO:0044389
GeneOntologyBiologicalProcesssodium ion transport

SCN10A SLC24A5 TRPM4 SLC5A12 NALCN ANO6 SCN2A TRPM2 SCN8A

6.80e-09275459GO:0006814
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN10A SLC24A5 TRPM4 NALCN ANO6 SCN2A TRPM2 SCN8A

1.46e-08208458GO:0035725
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SCN10A SLC24A5 TRPM4 CXCR3 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

5.47e-079424512GO:0098655
GeneOntologyBiologicalProcessmonoatomic cation transport

SCN10A SLC24A5 TRPM4 CXCR3 SLC5A12 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

6.91e-0711574513GO:0006812
GeneOntologyBiologicalProcessmetal ion transport

SCN10A SLC24A5 TRPM4 CXCR3 SLC5A12 CHRNA9 NALCN ANO6 SCN2A RYR3 TRPM2 SCN8A

1.03e-0610004512GO:0030001
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN10A TRPM4 SCN2A SCN8A

1.11e-0636454GO:0086010
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

SLC24A5 TRPM4 CXCR3 CHRNA9 NALCN ANO6 RYR3 TRPM2

1.85e-06392458GO:0070588
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SCN10A SLC24A5 TRPM4 CXCR3 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

3.21e-0611154512GO:0034220
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SCN10A SLC24A5 TRPM4 CXCR3 CHRNA9 NALCN ANO6 SCN2A RYR3 TRPM2 SCN8A

3.37e-069224511GO:0098662
GeneOntologyBiologicalProcessmonoatomic ion transport

SCN10A SLC24A5 TRPM4 CXCR3 SLC5A12 CHRNA9 NALCN ANO6 PIEZO1 SCN2A RYR3 TRPM2 SCN8A

4.70e-0613744513GO:0006811
GeneOntologyBiologicalProcessmembrane depolarization

SCN10A TRPM4 CHRNA9 SCN2A SCN8A

6.47e-06121455GO:0051899
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SCN10A SLC24A5 TRPM4 CXCR3 CHRNA9 NALCN ANO6 SCN2A RYR3 TRPM2 SCN8A

8.59e-0610174511GO:0098660
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN10A TRPM4 SCN2A SCN8A

1.01e-0562454GO:0086002
GeneOntologyBiologicalProcesscalcium ion transport

SLC24A5 TRPM4 CXCR3 CHRNA9 NALCN ANO6 RYR3 TRPM2

1.26e-05509458GO:0006816
GeneOntologyBiologicalProcessregulation of membrane potential

SCN10A TRPM4 CHRNA9 NALCN ANO6 PIEZO1 SCN2A SCN8A

2.47e-05559458GO:0042391
GeneOntologyBiologicalProcessdendritic cell chemotaxis

TRPM4 ANO6 TRPM2

3.41e-0529453GO:0002407
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN10A TRPM4 SCN2A SCN8A

3.86e-0587454GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN10A TRPM4 SCN2A SCN8A

5.01e-0593454GO:0086003
GeneOntologyBiologicalProcessdendritic cell migration

TRPM4 ANO6 TRPM2

6.59e-0536453GO:0036336
GeneOntologyBiologicalProcessresponse to ATP

TRPM4 NT5E RYR3

9.06e-0540453GO:0033198
GeneOntologyBiologicalProcesscardiac epithelial to mesenchymal transition

TGFBR1 RTN4 WNT16

9.06e-0540453GO:0060317
GeneOntologyBiologicalProcessbundle of His cell action potential

SCN10A TRPM4

9.71e-057452GO:0086043
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte signaling

SCN10A TRPM4

9.71e-057452GO:0086028
GeneOntologyBiologicalProcessstriated muscle contraction

SCN10A TRPM4 SCN2A RYR3 SCN8A

1.07e-04217455GO:0006941
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN10A TRPM4 SCN2A SCN8A

1.68e-04127454GO:0070252
GeneOntologyBiologicalProcessmononuclear cell migration

TRPM4 CXCR3 ANO6 RTN4 TRPM2

2.39e-04258455GO:0071674
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

SCN10A TRPM4

3.03e-0412452GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

SCN10A TRPM4

3.03e-0412452GO:0086016
GeneOntologyBiologicalProcessactin filament-based movement

SCN10A TRPM4 SCN2A SCN8A

3.42e-04153454GO:0030048
GeneOntologyBiologicalProcessneuronal action potential

SCN10A SCN2A SCN8A

3.52e-0463453GO:0019228
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR3 TRPM2

4.17e-0414452GO:0071415
GeneOntologyBiologicalProcesspositive regulation of transport

ABCB11 TRPM4 VPS11 CXCR3 ATAD1 ANO6 RTN4 TM7SF3 TRPM2

4.63e-041081459GO:0051050
GeneOntologyBiologicalProcessresponse to purine-containing compound

TRPM4 NT5E RYR3 TRPM2

4.66e-04166454GO:0014074
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN10A TRPM4 SCN2A SCN8A

4.77e-04167454GO:0060048
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte communication

SCN10A TRPM4

4.80e-0415452GO:0086069
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

SCN10A TRPM4

4.80e-0415452GO:0086067
GeneOntologyBiologicalProcessdetection of mechanical stimulus

SCN10A CHRNA9 PIEZO1

5.87e-0475453GO:0050982
GeneOntologyBiologicalProcessprotein homotetramerization

TRPM4 RYR3 TRPM2

6.34e-0477453GO:0051289
GeneOntologyBiologicalProcesscellular response to ATP

TRPM4 RYR3

9.52e-0421452GO:0071318
GeneOntologyBiologicalProcessaction potential

SCN10A TRPM4 SCN2A SCN8A

9.54e-04201454GO:0001508
GeneOntologyBiologicalProcessmyelination

ABCD2 SCN2A SCN8A CMTM8

1.05e-03206454GO:0042552
GeneOntologyBiologicalProcessaxon ensheathment

ABCD2 SCN2A SCN8A CMTM8

1.10e-03209454GO:0008366
GeneOntologyBiologicalProcessensheathment of neurons

ABCD2 SCN2A SCN8A CMTM8

1.10e-03209454GO:0007272
GeneOntologyBiologicalProcesspore complex assembly

ANO6 RTN4

1.14e-0323452GO:0046931
GeneOntologyBiologicalProcessregulation of fatty acid beta-oxidation

ABCB11 ABCD2

1.25e-0324452GO:0031998
GeneOntologyCellularComponentmonoatomic ion channel complex

SCN10A TRPM4 CHRNA9 NALCN SLCO6A1 ANO6 SCN2A RYR3 SCN8A

1.15e-07378469GO:0034702
GeneOntologyCellularComponenttransmembrane transporter complex

SCN10A TRPM4 CHRNA9 NALCN SLCO6A1 ANO6 NDUFS2 SCN2A RYR3 SCN8A

1.60e-075234610GO:1902495
GeneOntologyCellularComponenttransporter complex

SCN10A TRPM4 CHRNA9 NALCN SLCO6A1 ANO6 NDUFS2 SCN2A RYR3 SCN8A

2.55e-075504610GO:1990351
GeneOntologyCellularComponentsodium channel complex

SCN10A TRPM4 SCN2A SCN8A

4.68e-0729464GO:0034706
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN10A SCN2A SCN8A

6.64e-0617463GO:0001518
GeneOntologyCellularComponentcation channel complex

SCN10A TRPM4 SLCO6A1 SCN2A RYR3 SCN8A

1.22e-05235466GO:0034703
GeneOntologyCellularComponentmembrane protein complex

SCN10A TGFBR1 TRPM4 VPS11 HM13 CHRNA9 NALCN SLCO6A1 ANO6 NDUFS2 SCN2A RYR3 SCN8A

1.36e-0514984613GO:0098796
GeneOntologyCellularComponentsynaptic membrane

SCN10A CHRNA9 ATAD1 NT5E ANO6 RTN4 SCN2A SCN8A

3.57e-05583468GO:0097060
GeneOntologyCellularComponentnode of Ranvier

SCN2A SCN8A

8.78e-0420462GO:0033268
GeneOntologyCellularComponentcholinergic synapse

CHRNA9 ANO6

1.06e-0322462GO:0098981
GeneOntologyCellularComponentaxon initial segment

SCN2A SCN8A

1.85e-0329462GO:0043194
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

1.31e-045192HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

1.31e-045192HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

1.31e-045192HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

1.31e-045192HP:0032823
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

1.31e-045192HP:0032906
HumanPhenoNormal interictal EEG

SCN2A SCN8A

1.96e-046192HP:0002372
HumanPhenoCalcaneovalgus deformity

MAN2B1 NALCN SCN2A

2.45e-0434193HP:0001848
HumanPhenoDeformed tarsal bones

MAN2B1 NALCN SCN2A

2.67e-0435193HP:0008119
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

2.74e-047192HP:0032678
MousePhenoabnormal nervous system electrophysiology

SCN10A CHRNA9 ABCD2 NALCN SCN2A TRPM2 SCN8A

2.53e-05329387MP:0002272
DomainIon_trans_dom

SCN10A TRPM4 NALCN SCN2A RYR3 TRPM2 SCN8A

1.15e-08114467IPR005821
DomainIon_trans

SCN10A TRPM4 NALCN SCN2A RYR3 TRPM2 SCN8A

1.15e-08114467PF00520
DomainNa_channel_asu

SCN10A SCN2A SCN8A

1.66e-0610463IPR001696
DomainNa_trans_assoc

SCN10A SCN2A SCN8A

1.66e-0610463IPR010526
DomainNa_trans_assoc

SCN10A SCN2A SCN8A

1.66e-0610463PF06512
DomainChannel_four-helix_dom

SCN10A NALCN SCN2A SCN8A

1.16e-0557464IPR027359
Domain-

SCN10A NALCN SCN2A SCN8A

1.16e-05574641.20.120.350
DomainNa_trans_cytopl

SCN2A SCN8A

8.85e-056462PF11933
DomainNa_trans_cytopl

SCN2A SCN8A

8.85e-056462IPR024583
DomainIQ_motif_EF-hand-BS

SCN10A SCN2A SCN8A

1.41e-0390463IPR000048
DomainIQ

SCN10A SCN2A SCN8A

1.55e-0393463PS50096
DomainABC_TM1F

ABCB11 ABCD2

2.15e-0328462PS50929
DomainABC1_TM_dom

ABCB11 ABCD2

2.15e-0328462IPR011527
DomainABC_transporter_CS

ABCB11 ABCD2

4.80e-0342462IPR017871
DomainAAA+_ATPase

ABCB11 ATAD1 ABCD2

5.35e-03144463IPR003593
DomainAAA

ABCB11 ATAD1 ABCD2

5.35e-03144463SM00382
DomainABC_TRANSPORTER_2

ABCB11 ABCD2

6.23e-0348462PS50893
DomainABC_tran

ABCB11 ABCD2

6.23e-0348462PF00005
DomainABC_TRANSPORTER_1

ABCB11 ABCD2

6.48e-0349462PS00211
DomainABC_transporter-like

ABCB11 ABCD2

6.74e-0350462IPR003439
Domain-

ABCB11 LRGUK CHD3 ATAD1 ABCD2 SULT2A1

9.56e-037464663.40.50.300
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM4 NALCN ANO6 RYR3 TRPM2

4.89e-0699365MM14910
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM4 NALCN ANO6 RYR3 TRPM2

6.85e-06106365M27200
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN10A SCN2A SCN8A

6.55e-0531363M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN10A SCN2A SCN8A

7.21e-0532363M27455
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 NALCN ANO6 RYR3 TRPM2

7.89e-05176365MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 NALCN ANO6 RYR3 TRPM2

9.49e-05183365M997
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TRPM4 TAS2R7 SCN2A

2.30e-0447363M42524
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC24A5 TRPM4 SLC5A12 ABCD2 NALCN ANO6 RYR3 TRPM2

2.58e-04681368MM14985
PathwayREACTOME_CARDIAC_CONDUCTION

SCN10A SCN2A RYR3 SCN8A

3.24e-04130364M27454
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC24A5 TRPM4 SLC5A12 ABCD2 NALCN ANO6 RYR3 TRPM2

4.37e-04736368M27287
PathwayWP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY

ABCB11 SULT2A1

8.42e-0417362M39666
PathwayWP_FARNESOID_X_RECEPTOR_PATHWAY

ABCB11 SULT2A1

1.06e-0319362M39411
PathwayREACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT

ATAD1 ABCD2

1.06e-0319362MM15651
PathwayREACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT

ATAD1 ABCD2

1.17e-0320362M27930
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN10A SCN2A SCN8A

4.61e-08647323652591
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN10A SCN2A SCN8A

1.93e-07947316382098
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN10A SCN2A SCN8A

6.55e-071347315123669
Pubmed

Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.

TRPM4 PIEZO1

1.79e-06247238098265
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

1.79e-06247235348308
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

1.79e-06247215760941
Pubmed

Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis.

ANO6 PIEZO1

1.79e-06247238033286
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

1.79e-06247217805013
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

1.79e-06247218601978
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

1.79e-06247219465131
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

1.79e-06247223735284
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

TRPM4 HM13 MBOAT7 ANO6 NDUFS2 RTN4 USP33

3.02e-0646847731056421
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN2A SCN8A

5.36e-06347232845893
Pubmed

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

SCN2A SCN8A

5.36e-06347216033895
Pubmed

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

SCN2A SCN8A

5.36e-06347229991598
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN2A SCN8A

5.36e-06347228518218
Pubmed

Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain.

SCN10A SCN8A

5.36e-06347229497094
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN2A SCN8A

5.36e-06347217928448
Pubmed

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.

SCN2A SCN8A

5.36e-06347238514708
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN2A SCN8A

1.07e-05447217537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN2A SCN8A

1.07e-05447235031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN2A SCN8A

1.07e-05447229578003
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN2A SCN8A

1.07e-05447221156207
Pubmed

Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

SCN2A SCN8A

1.78e-05547224077057
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN8A

1.78e-05547217724025
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN10A SCN8A

2.67e-05647216029194
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN2A SCN8A

2.67e-05647217513486
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN10A SCN8A

2.67e-05647223711479
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

TGFBR1 MAN2B1 HM13 MBOAT7 ANO6 DIPK1A PIEZO1 RTN4 A4GALT

2.83e-05120147935696571
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN2A SCN8A

3.74e-05747225818041
Pubmed

Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.

SCN10A PIEZO1

4.98e-05847227161260
Pubmed

Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.

FMN1 RYR3

6.40e-05947217554679
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN2A SCN8A

6.40e-05947215746173
Pubmed

USP33 promotes pancreatic cancer malignant phenotype through the regulation of TGFBR2/TGFβ signaling pathway.

TGFBR1 USP33

9.75e-051147237322017
Pubmed

Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.

FMN1 RYR3

9.75e-051147219096130
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN2A SCN8A

1.17e-041247230175250
Pubmed

Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects.

RTN4 WNT16

1.17e-041247219156209
Pubmed

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.

TRPM4 TRPM2

1.17e-041247219850157
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

SCN2A SCN8A

1.38e-041347216723544
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

TGFBR1 MAN2B1 ATAD1 ANO6 USP33

1.56e-0437847534315543
Pubmed

A genome-wide association study identifies two new risk loci for Graves' disease.

TSHR CHRNA9

2.12e-041647221841780
Pubmed

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.

ABCB11 PIEZO1

2.40e-041747224647736
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

HM13 ATAD1 MBOAT7 NDUFS2 RTN4

2.59e-0442247527342126
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

SCN2A SCN8A

2.70e-041847237321992
Pubmed

Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.

NALCN CMTM8

2.70e-041847219308021
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

TRPM4 VPS11 HM13 RALGAPA2 MBOAT7 CENPI

3.99e-0471947635337019
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM4 TRPM2

4.84e-042447233884443
Pubmed

Brugada Syndrome

SCN10A TRPM4

4.84e-042447220301690
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM4 TRPM2

5.26e-042547216382100
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

TRPM4 HM13 MBOAT7 PIEZO1 RTN4

5.56e-0449947522810586
Pubmed

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.

TGFBR1 HM13 ATAD1 RTN4

5.74e-0428247435007762
Pubmed

Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.

SLC24A5 CHRNA9

6.14e-042747225133637
Pubmed

An introduction to TRP channels.

TRPM4 TRPM2

6.14e-042747216460286
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

VPS11 USP54 ANO6 RTN4

7.05e-0429847432353859
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TMEM186 HM13 MBOAT7 ANO6 NDUFS2 PIEZO1 RTN4 USP33

7.79e-04148747833957083
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM4 TRPM2

9.19e-043347219834762
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

HM13 MBOAT7 ANO6 RTN4 USP33

9.94e-0456847537774976
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

VPS11 USP54 USP33

1.05e-0314747329576527
InteractionSCN11A interactions

SCN10A NALCN SCN8A

4.65e-0615453int:SCN11A
Cytoband12q12

ABCD2 ANO6

1.08e-034747212q12
CytobandEnsembl 112 genes in cytogenetic band chr12q12

ABCD2 ANO6

1.93e-0363472chr12q12
Cytoband1p31.1

SAMD13 USP33

2.44e-03714721p31.1
GeneFamilySodium voltage-gated channel alpha subunits

SCN10A SCN2A SCN8A

5.54e-0793531203
GeneFamilyTransient receptor potential cation channels

TRPM4 TRPM2

1.33e-0328352249
GeneFamilyUbiquitin specific peptidases

USP54 USP33

5.25e-0356352366
CoexpressionGSE23321_CENTRAL_MEMORY_VS_NAIVE_CD8_TCELL_UP

ABCD2 NT5E ANO6 TM7SF3 CENPI

2.84e-05199475M8435
CoexpressionGSE27786_CD8_TCELL_VS_NKTCELL_UP

TMEM186 SLC5A12 HM13 DIPK1A RYR3

2.91e-05200475M4839
ToppCellLPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HM13 ABCD2 SLCO6A1 CENPI

1.94e-05151474f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC5A12 NALCN NT5E RYR3

2.38e-05159474fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC5A12 NALCN NT5E RYR3

2.38e-05159474aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC5A12 NALCN NT5E RYR3

2.38e-051594748bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TSHR HM13 DIPK1A CENPI

2.88e-051674740130743084dbcb20e10f96715d30961122150cbf
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TSHR HM13 DIPK1A CENPI

2.88e-051674747bcae3797d3a0811e7f39885afdfd29ec517f11b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TSHR HM13 DIPK1A CENPI

2.88e-05167474c6f0209a1ad797631fdfa3efab6db6b1d3e8e315
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

NALCN GALNT13 SCN2A SCN8A

4.03e-0518247457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RALGAPA2 NALCN PIEZO1 A4GALT

4.12e-05183474764ea07621f77fbd13a877aed5806ae2b3dfb43e
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RALGAPA2 NALCN PIEZO1 A4GALT

4.12e-0518347438a54216458ad57f356bb4ddf272e1af8036ddeb
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHR ABCD2 MFSD13A TM7SF3

4.30e-0518547453854a9ec87c24c360541c83d86d8fafb303ad58
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHR ABCD2 MFSD13A TM7SF3

4.30e-05185474a61fc7a3700a1efcf640bef7680c0443ee148a46
ToppCellBAL-Control-Myeloid-MoAM-MoAM4|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TGFBR1 HM13 FMN1 TRPM2

4.30e-05185474274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCellBAL-Control-Myeloid-MoAM-MoAM4-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TGFBR1 HM13 FMN1 TRPM2

4.30e-05185474b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SAMD13 TRPM4 TSHR WNT16

4.39e-05186474948815663c212c4311329d503b5991cbbbff9808
ToppCellControl-Myeloid-MoAM3,_VCAN|Myeloid / Condition, Lineage and Cell class

TGFBR1 HM13 RYR3 TRPM2

4.39e-051864740bf16ac48931b62bb3c33d63ff4279654148e293
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD3 CHRNA9 SCN2A SCN8A

4.39e-051864747278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TGFBR1 ABCB11 TSHR MAN2B1

4.48e-051874742a7226adb4d15b92936603bdf05421c50b21f003
ToppCellwk_15-18-Hematologic-Myeloid-Basophil|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SAMD13 RALGAPA2 MBOAT7 TRPM2

4.58e-051884743638d85452de15a060146628fbbad9d2a36feb13
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NALCN GALNT13 SCN2A SCN8A

4.58e-05188474c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellControl-Myeloid-MoAM4|Control / Disease group,lineage and cell class (2021.01.30)

TGFBR1 HM13 FMN1 TRPM2

4.97e-051924741da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR1 PIEZO1 SCN2A TM7SF3

5.17e-0519447404bfc555743f7d8821439d05ae442d15e9886c59
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR1 MBOAT7 PIEZO1 SCN2A

5.17e-051944744579b4a44f7c731553a284843c296866027d7c0e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MBOAT7 PIEZO1 RTN4 SCN2A

5.71e-051994745059a1d4df7d9989c922007a8dcba98b1f5687d5
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MBOAT7 PIEZO1 RTN4 SCN2A

5.71e-05199474a4ebb0598e9a0c9f6e39a0db6d0623654c2a7d88
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RALGAPA2 FMN1 GALNT13 CMTM8

5.82e-052004740eb9ad8c0373bcc62029ec21c590ed03aaacd039
DrugAPETx2 protein, Anthopleura elegantissima

SCN10A SCN2A SCN8A

3.29e-084473ctd:C501880
DrugAPETx1, Anthopleura elegantissima

SCN10A SCN2A SCN8A

1.64e-076473ctd:C475726
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN10A SCN2A SCN8A

4.58e-078473ctd:C489827
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN10A SCN2A SCN8A

3.95e-0710453DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN10A SCN2A SCN8A

3.95e-0710453DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN10A SCN2A SCN8A

7.22e-0712453DOID:0060170 (implicated_via_orthology)
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

6.82e-063452cv:C5575231
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

3.40e-056452C0220669
Diseasetrans fatty acid measurement, trans/trans-18:2 fatty acid measurement

DIPK1A RYR3

6.14e-0424452EFO_0006821, EFO_0006826
DiseaseBrugada Syndrome (disorder)

SCN10A TRPM4

6.14e-0424452C1142166
DiseaseColorectal Carcinoma

TGFBR1 ABCB11 ATAD1 ABCD2 RTN4 WNT16

6.56e-04702456C0009402
Diseasemaximal oxygen uptake measurement

SCN10A TSHR

7.22e-0426452EFO_0004887

Protein segments in the cluster

PeptideGeneStartEntry
LLYAFVGVKFRERMW

CXCR3

316

P49682
ARVYNMFWVFDEVKR

ABCD2

421

Q9UBJ2
MFWVFDEVKRGIYKR

ABCD2

426

Q9UBJ2
IGFKFTFFVSIMIYW

A4GALT

26

Q9NPC4
KFYFRRIMRMEIGWF

ABCB11

176

O95342
VAKVIDRFFMWIFFI

CHRNA9

451

Q9UGM1
VFMVWYEFCSDFKTI

FMN1

1351

Q68DA7
FAVFMGVWVTLFLEF

ANO6

381

Q4KMQ2
PVFFAFRMRFYVAWI

MBOAT7

236

Q96N66
FIYDVFWVFGTNVMV

HM13

216

Q8TCT9
EKSEYWFFVIFMLLR

LRGUK

341

Q96M69
YMAARVVFIKWIVTF

RALGAPA2

296

Q2PPJ7
KGFWTEFMGRVFKYL

PHOSPHO2

41

Q8TCD6
FWLFEEREKMFEFYE

NDUFS2

201

O75306
AKFITFGMLIYFIAW

GPRC6A

781

Q5T6X5
VWMDEFKDFFYIISP

GALNT13

371

Q8IUC8
EREFQMWAPKFYVVT

CHD3

801

Q12873
FFFGRLDYQDKWVRM

MAN2B1

216

O00754
KVLFYRWLVAMFDFI

CENPI

161

Q92674
MKYLFFSWLVVFVGS

DIPK1A

26

Q5T7M9
FVSVYKINKMAFWVG

MFSD13A

41

Q14CX5
FAVLMWVFTYVGALF

RTN4

1121

Q9NQC3
FIAFYGDRKKVIWFV

SLCO6A1

161

Q86UG4
WAVMDVVNYFRTVGF

SAMD13

51

Q5VXD3
VLVSGYFFWKNMKFI

SULT2A1

126

Q06520
FKRADIYAMGLVFWE

TGFBR1

396

P36897
IWFTVYKGAEVAHFM

NT5E

91

P21589
FGAVTYFTIKWMVDA

ATAD1

26

Q8NBU5
RVPAFGWVMFVAVFY

CMTM8

66

Q8IZV2
YATGKEMRIIDFFWT

TAS2R7

76

Q9NYW3
MAAYLQWRRFVFFDK

VPS11

1

Q9H270
VKVLFSFFWMLFVGL

RYR3

4181

Q15413
RVFTFIFVFEMLLKW

SCN10A

1191

Q9Y5Y9
IFVFEMLLKWVAYGF

SCN10A

1196

Q9Y5Y9
MKDVFFFLFLLAVWV

TRPM2

931

O94759
EMLLKWVAYGFQVYF

SCN2A

1256

Q99250
AETEKFWMFYRFDAI

TMEM186

51

Q96B77
KNYFVITFFMSAIWI

SLC24A5

331

Q71RS6
EMLLKWTAYGFVKFF

SCN8A

1246

Q9UQD0
DVQYGMWFSRKFLDF

WNT16

171

Q9UBV4
DMLKVAVFRYLFWLV

PIEZO1

1156

Q92508
MEVKNFAVWDYVVFA

SLC5A12

1

Q1EHB4
MMKDVFFFLFFLGVW

TRPM4

926

Q8TD43
GWIAFFMEYVKRFVV

USP33

541

Q8TEY7
WKTELFFIGFIIMGF

TM7SF3

316

Q9NS93
FFFQTKIRKWMYFDD

USP54

306

Q70EL1
IMGYKFLRIVVWFVS

TSHR

411

P16473
TKYARWIAFTGMILF

MOSMO

96

Q8NHV5
SYVKDRWCVFDGFMV

NALCN

101

Q8IZF0