Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabsent hippocampal fimbria

LHX5 HTT

2.15e-053382MP:0009324
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

6.36e-084483PF14914
DomainLRRC37_N

LRRC37A LRRC37A3 LRRC37A2

6.36e-084483IPR032754
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

6.36e-084483IPR029423
DomainLRRC37

LRRC37A LRRC37A3 LRRC37A2

6.36e-084483PF15779
DomainLRRC37A/B-like

LRRC37A LRRC37A3 LRRC37A2

6.36e-084483IPR015753
DomainARM-type_fold

PKP4 TNPO3 FMNL1 TBCD HTT

1.73e-03339485IPR016024
Domain-

PKP4 TNPO3 TBCD HTT

2.51e-032224841.25.10.10
DomainARM-like

PKP4 TNPO3 TBCD HTT

5.05e-03270484IPR011989
Domain-

RNF152 TRIM25 USP51 CBLL2 BAZ1B

5.75e-034494853.30.40.10
DomainZnf_RING/FYVE/PHD

RNF152 TRIM25 USP51 CBLL2 BAZ1B

6.30e-03459485IPR013083
DomainHEAT

TBCD HTT

6.77e-0348482PF02985
DomainRING

RNF152 TRIM25 CBLL2 BAZ1B

7.72e-03305484SM00184
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A LRRC37A3 LRRC37A2

1.05e-08449322419166
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A LRRC37A3 LRRC37A2

3.13e-071049323064749
Pubmed

SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein.

SEL1L HTT

1.94e-06249233576152
Pubmed

Role of defective calcium regulation in cardiorespiratory dysfunction in Huntington's disease.

RYR2 HTT

1.94e-06249232897880
Pubmed

The armadillo protein p0071 regulates Rho signalling during cytokinesis.

PKP4 ECT2

1.16e-05449217115030
Pubmed

A protein interaction landscape of breast cancer.

SDSL GAK TRIM25 ACO2 PKP4 LRP1 TNPO3

2.86e-0563449734591612
Pubmed

Dissecting the role of Rho-mediated signaling in contractile ring formation.

ECT2 CIT

2.91e-05649216236794
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

AFM ENTPD5 LRP1 SPARCL1 PLXND1

3.10e-0525749516335952
Pubmed

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.

CSRP3 RYR2

8.69e-051049214963485
Pubmed

The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly.

CSRP3 RYR2

1.06e-041149227217161
Pubmed

USP51 promotes deubiquitination and stabilization of ZEB1.

USP51 USP29

1.50e-041349229119051
Pubmed

Positional cloning of the murine flavivirus resistance gene.

SDSL LHX5

1.75e-041449212080145
Pubmed

Functional proteomics mapping of a human signaling pathway.

LRP1 SPARCL1 TNPO3 FMNL1 RYR2 TBCD

1.77e-0459149615231748
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

SEL1L GAK ACO2 CPNE3 LRP1 TNPO3

3.92e-0468649628380382
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ZBED4 CPNE3 PLXND1

4.09e-041024939734811
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ATP11B CIT TBCD

4.09e-0410249310231032
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

WSCD1 LRRC37A LRRC37A3

4.45e-041054939628581
Pubmed

Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.

ACO2 MDH1

5.26e-042449219110265
Pubmed

Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.

ACO2 OSBP2

5.26e-042449211258795
Pubmed

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.

FMNL1 ZMYM4

7.71e-042949221834987
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SDSL ZBED4 PLXND1 CIT TNPO3 TBCD HTT

8.59e-04110549735748872
Pubmed

Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle.

AMPD1 CSRP3

9.39e-043249217904117
Pubmed

Hypertrophic Cardiomyopathy Overview

CSRP3 RYR2

1.06e-033449220301725
Pubmed

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.

CPNE3 CRYBG3 FMNL1

1.09e-0314349330397336
Pubmed

Characterization of potential S-nitrosylation sites in the myocardium.

ACO2 MDH1

1.19e-033649221278135
Pubmed

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.

ACO2 MDH1 CSRP3 RYR2

1.22e-0333149429199018
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

SEL1L TRIM25 HTT

1.25e-0315049332423001
Pubmed

Tagging genes with cassette-exchange sites.

BAZ1B ECT2 CIT ZMYM4

1.27e-0333549415741177
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

GAK CPNE3 BAZ1B CRYBG3 ZMYM4

1.40e-0358849538580884
InteractionCOMMD4 interactions

TRIM25 ECT2 CIT TBCD HTT

3.78e-06106455int:COMMD4
InteractionGPD1 interactions

ACO2 MDH1 HTT

1.79e-0523453int:GPD1
InteractionPABPC1L interactions

TRIM25 ECT2 CIT

2.93e-0527453int:PABPC1L
InteractionPID1 interactions

TRIM25 LRP1 CIT

2.93e-0527453int:PID1
InteractionCHCHD3 interactions

TRIM25 ACO2 CPNE3 ECT2 FMNL1 HTT

3.81e-05284456int:CHCHD3
InteractionSPTB interactions

ECT2 CIT CSRP3 HTT

4.22e-0587454int:SPTB
InteractionPLXND1 interactions

TRIM25 PLXND1 CIT

4.48e-0531453int:PLXND1
InteractionHIP1 interactions

GAK TRIM25 CIT HTT

5.48e-0593454int:HIP1
InteractionGNAL interactions

TRIM25 ECT2 HTT

7.67e-0537453int:GNAL
InteractionHSP90B1 interactions

SEL1L DNAH10 LRP1 ECT2 CIT FMNL1 ZMYM4 HTT

8.42e-05650458int:HSP90B1
Cytoband12q24

LHX5 CIT

3.30e-042549212q24
Cytoband3q11.2

CRYBG3 GABRR3

3.57e-04264923q11.2
CytobandEnsembl 112 genes in cytogenetic band chr12q24

SDSL DNAH10 LHX5 CIT

1.01e-03415494chr12q24
CytobandEnsembl 112 genes in cytogenetic band chr3q11

CRYBG3 GABRR3

1.54e-0354492chr3q11
Cytoband17q21.31

LRRC37A LRRC37A2

3.51e-038249217q21.31
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AMPD1 DNAH10 CIT RYR2

1.35e-0513249402491930097b75aaeedab9e8200711b0dc610944
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

COL4A6 RNF152 SPARCL1 RYR2

2.74e-051584948d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-6|TCGA-Colorectal / Sample_Type by Project: Shred V9

AMPD1 RNF152 ENTPD5 TNFRSF13B

3.02e-051624947f9385aa749bfb2fa9fee6939fe46d946bc21d31
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

SDSL DNAH10 BAZ1B CRYBG3

3.25e-051654948728f927502e56f2768b4224e9111939d3d7815a
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

COL4A6 RNF152 SPARCL1 RYR2

3.82e-05172494c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

ATP11B CPNE3 LRP1 CRYBG3

4.09e-051754940cc215109d9915af47e4d0a120ce2e46910715fa
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

SEL1L TRIM25 OSBP2 HTT

4.18e-051764943de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SDSL MDH1 CSRP3 RYR2

4.66e-0518149409a574a3257e25c8b05a2ab20623a6b07331411a
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SDSL MDH1 CSRP3 RYR2

4.66e-05181494ac4142aa93706b7067f63d2d38e2456859e60768
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B_plasma-Plasma_cells|GI_small-bowel / Manually curated celltypes from each tissue

SEL1L AMPD1 TNFRSF13B CRYBG3

4.86e-05183494ab5aaafcfd7b97330be6774be4c72611ca85257c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPARCL1 PLXND1 RYR2 TBCD

4.86e-05183494dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPARCL1 PLXND1 RYR2 TBCD

4.86e-051834944759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B_plasma|GI_small-bowel / Manually curated celltypes from each tissue

SEL1L AMPD1 TNFRSF13B CRYBG3

4.86e-05183494193bfb787c1b36c8fabf4b00fafb5b398de6b999
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-Pecam____fenestrated_capillary_endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WSCD1 DRAM1 SPARCL1 PLXND1

5.86e-051924941a2dd398141069ef6ad2f6bb4bae0bac1c6b98e8
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-fenestrated_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WSCD1 DRAM1 SPARCL1 PLXND1

5.86e-051924945dd206adb8b84c374ee931f7df2a8b8cf040efab
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)

SEL1L SDSL LRP1 PLXND1

6.47e-05197494c747d05bb032abf8dad46ff6f4d1951bbe64b3b4
ToppCellcritical-Myeloid-Non-resident_Macrophage|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SDSL DRAM1 LRP1 PLXND1

6.73e-05199494193325768b17d3123ae855317f381a01088b5dac
ToppCellSepsis-Bac-SEP-Myeloid-tDC|Bac-SEP / Disease, condition lineage and cell class

SDSL DNAH10 BAZ1B CRYBG3

6.73e-05199494a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNF152 AFM ENTPD5 MDH1

6.86e-05200494825aad08431dd6b54aa636ace6efc821dfaf8014
DiseaseMuscle Weakness

AMPD1 TBCD

9.71e-0510442C0151786
DiseaseBMI-adjusted waist-hip ratio, physical activity measurement

DNAH10 BAZ1B PLXND1

1.51e-0469443EFO_0007788, EFO_0008002
Diseasealpha-L-iduronidase measurement

GAK DRAM1

2.91e-0417442EFO_0020139
DiseaseLiver Cirrhosis, Experimental

DRAM1 AFM GPAM MDH1 ECT2 FMNL1

9.64e-04774446C0023893
Diseasecongestive heart failure (implicated_via_orthology)

CSRP3 RYR2

1.72e-0341442DOID:6000 (implicated_via_orthology)
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

DNAH10 ACO2 LRP1 HTT

2.10e-03364444EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseasemultiple sclerosis symptom measurement

DNAH10 USP29

2.16e-0346442EFO_0803536
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

PLXND1 GABRR3

2.44e-0349442DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
AAICCALHEVTSKNM

PKP4

936

Q99569
HVASVLCQRAKVAMS

ACO2

21

Q99798
QLHTRVSRCQVCMKS

COL4A6

1676

Q14031
KISRQMAQNCEAHTC

CRYBG3

951

Q68DQ2
QCIRDTSKVMNHICS

AFM

276

P43652
RGSHVLSCMVKTEQC

BAZ1B

1421

Q9UIG0
MAAQCVTKVALNVSC

CPNE3

1

O75131
NCRKVDTHIHAAACM

AMPD1

296

P23109
HKRGSVFMCSIVQQC

CBLL2

106

Q8N7E2
MRATKCAVCLDTVHF

CIT

1371

O14578
MQCHLNGATVKTDVC

CFAP206

366

Q8IYR0
MLCRHVANTICKADA

ECT2

786

Q9H8V3
TCHIRMVISAVSCAA

DRAM1

156

Q8N682
LKMDCSGAHVQVTCA

LRRC37A3

1501

O60309
MLVVSCVCSAVSHRN

ENTPD5

11

O75356
LKMDCSGAHVQVTCA

LRRC37A2

1501

A6NM11
LKMDCSGAHVQVTCA

LRRC37A

1501

A6NMS7
LCSCARNFMKTHNTC

LRP1

3846

Q07954
SSAMSAAKAICDHVR

MDH1

241

P40925
MARVKVAACNVHSTC

PLXND1

541

Q9Y4D7
RLKALNTCMSHICAV

OR51I1

236

Q9H343
RSKVFHLNCFTCMVC

LHX5

81

Q9H2C1
KAVHCTSSVEQMCLV

OSBP2

566

Q969R2
KNVCVVHCMDGRAAS

GAK

501

O14976
VCAASNIKMTHQRCS

GABRR3

21

A8MPY1
VTCKLACTAVRNCVM

HTT

821

P42858
VSQKDDVHVCIMCLR

FMNL1

221

O95466
HCMACRKALDSTTVA

CSRP3

36

P50461
TNEIDKMCFHCVRNC

DNAH10

911

Q8IVF4
VHESIKRSNCYMVCA

RYR2

1476

Q92736
CDHMSVAKISCGNVR

OR52N1

181

Q8NH53
KHTCCSVCLQQMRTS

RNF152

31

Q8N8N0
MRSCHTAVELFKNVC

SEL1L

536

Q9UBV2
RAVKIRHCNSCMKTV

RPL37AP8

51

A6NKH3
RSVHLCCTKVVNYSM

PRAMEF19

176

Q5SWL8
ASKSCAIMSTHIVAC

GPAM

476

Q9HCL2
AKTVAARALECMQVC

SDSL

231

Q96GA7
ARALECMQVCKIHSE

SDSL

236

Q96GA7
HEKLFMEVCRNCSAV

ATP11B

776

Q9Y2G3
AKSCICHVCSTHMNR

USP51

231

Q70EK9
RVHAVDSCMSFQCKR

SPARCL1

426

Q14515
VKTCLVCMASFCQEH

TRIM25

116

Q14258
CQMCKQKSCVARHTF

USP29

486

Q9HBJ7
QAVAKLMSVDCRCHG

WNT16

211

Q9UBV4
KAIHNICSVCRDHMA

TNPO3

521

Q9Y5L0
TCMSCKTICNHQSQR

TNFRSF13B

46

O14836
AHTCERIMCCVAQQA

TBCD

896

Q9BTW9
LRKMTVSHCQDACAE

WSCD1

166

Q658N2
STKCSMCQKNAVIRH

ZMYM4

441

Q5VZL5
NSKAVCIHCMNEFSR

ZBED4

301

O75132