Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE2B SPDYE6 SPDYE2	3.83e-06	27	23	3	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE2B SPDYE6 SPDYE2	4.29e-06	28	23	3	GO:0099602
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	DYRK1A DYRK1B	1.33e-03	47	23	2	GO:0004712
GeneOntologyMolecularFunction	peptide hormone binding	VIPR1 GLP2R	1.82e-03	55	23	2	GO:0017046
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE2B SPDYE6 SPDYE2	2.74e-06	25	23	3	GO:0045737
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein kinase activity	SPDYE2B SPDYE6 SPDYE2	3.90e-06	28	23	3	GO:1904031
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE2B SPDYE6 SPDYE2	1.62e-04	96	23	3	GO:0000079
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein kinase activity	SPDYE2B SPDYE6 SPDYE2	1.82e-04	100	23	3	GO:1904029
Domain	Spy1	SPDYE2B SPDYE6 SPDYE2	2.67e-07	11	23	3	PF11357
Domain	Speedy	SPDYE2B SPDYE6 SPDYE2	2.67e-07	11	23	3	IPR020984
Domain	HormR	VIPR1 GLP2R	4.28e-04	25	23	2	SM00008
Domain	HRM	VIPR1 GLP2R	5.38e-04	28	23	2	PF02793
Domain	GPCR_2_secretin-like_CS	VIPR1 GLP2R	7.95e-04	34	23	2	IPR017983
Domain	G_PROTEIN_RECEP_F2_1	VIPR1 GLP2R	1.10e-03	40	23	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	VIPR1 GLP2R	1.10e-03	40	23	2	PS50227
Domain	GPCR_2_extracellular_dom	VIPR1 GLP2R	1.10e-03	40	23	2	IPR001879
Domain	7tm_2	VIPR1 GLP2R	1.71e-03	50	23	2	PF00002
Domain	G_PROTEIN_RECEP_F2_2	VIPR1 GLP2R	1.71e-03	50	23	2	PS00650
Domain	GPCR_2-like	VIPR1 GLP2R	2.46e-03	60	23	2	IPR017981
Domain	GPCR_2_secretin-like	VIPR1 GLP2R	2.46e-03	60	23	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	VIPR1 GLP2R	2.54e-03	61	23	2	PS50261
Domain	Ser/Thr_kinase_AS	DYRK1A CDK18 DYRK1B	9.24e-03	357	23	3	IPR008271
Domain	S_TKc	DYRK1A CDK18 DYRK1B	9.38e-03	359	23	3	SM00220
Domain	PROTEIN_KINASE_ST	DYRK1A CDK18 DYRK1B	9.59e-03	362	23	3	PS00108
Domain	Protein_kinase_ATP_BS	DYRK1A CDK18 DYRK1B	1.09e-02	379	23	3	IPR017441
Domain	Pkinase	DYRK1A CDK18 DYRK1B	1.10e-02	381	23	3	PF00069
Domain	PROTEIN_KINASE_ATP	DYRK1A CDK18 DYRK1B	1.81e-02	459	23	3	PS00107
Domain	Prot_kinase_dom	DYRK1A CDK18 DYRK1B	2.14e-02	489	23	3	IPR000719
Domain	PROTEIN_KINASE_DOM	DYRK1A CDK18 DYRK1B	2.19e-02	493	23	3	PS50011
Pathway	BIOCARTA_SHH_PATHWAY	DYRK1A DYRK1B	1.10e-04	15	15	2	MM1498
Pathway	BIOCARTA_SHH_PATHWAY	DYRK1A DYRK1B	1.26e-04	16	15	2	M11792
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	VIPR1 GLP2R	2.88e-04	24	15	2	MM15992
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	VIPR1 GLP2R	2.88e-04	24	15	2	M39643
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	VIPR1 GLP2R	5.47e-04	33	15	2	M10322
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	VIPR1 GLP2R	5.47e-04	33	15	2	MM15066
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	VIPR1 GLP2R	1.81e-03	60	15	2	MM14964
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE2B SPDYE6 SPDYE2	2.12e-08	9	23	3	36272447
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE2B SPDYE6 SPDYE2	7.19e-08	13	23	3	15611625
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE2B SPDYE6 SPDYE2	1.71e-07	17	23	3	15574121
Pubmed	Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.	DYRK1A DYRK1B	4.18e-07	2	23	2	30501876
Pubmed	Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.	DYRK1A DYRK1B	4.18e-07	2	23	2	34969768
Pubmed	Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.	DYRK1A DYRK1B	1.25e-06	3	23	2	32640193
Pubmed	DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.	DYRK1A DYRK1B	1.25e-06	3	23	2	30496304
Pubmed	DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.	DYRK1A DYRK1B	1.25e-06	3	23	2	21777625
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE6 SPDYE2	1.25e-06	3	23	2	22763696
Pubmed	Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.	DYRK1A DYRK1B	2.51e-06	4	23	2	14593110
Pubmed	The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2.	DYRK1A DYRK1B	2.51e-06	4	23	2	27307198
Pubmed	Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.	DYRK1A DYRK1B	2.51e-06	4	23	2	35165364
Pubmed	The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.	DYRK1A DYRK1B	4.18e-06	5	23	2	20940704
Pubmed	Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.	DYRK1A DYRK1B	6.26e-06	6	23	2	14500717
Pubmed	Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.	DYRK1A DYRK1B	8.77e-06	7	23	2	9748265
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	DNAH2 ZNF862 USP33 DYRK1B	1.57e-05	233	23	4	37704626
Pubmed	Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.	VIPR1 GLP2R	1.88e-05	10	23	2	15670850
Pubmed	Dual-utility NLS drives RNF169-dependent DNA damage responses.	DYRK1A DYRK1B	2.75e-05	12	23	2	28325877
Pubmed	An ID2-dependent mechanism for VHL inactivation in cancer.	DYRK1A DYRK1B	1.35e-04	26	23	2	26735018
Pubmed	Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient.	DYRK1A DYRK1B	6.53e-04	57	23	2	34671097
Cytoband	7q22.1	SPDYE2B SPDYE6 SPDYE2	2.48e-05	113	23	3	7q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	SPDYE2B SPDYE6 SPDYE2	1.77e-04	219	23	3	chr7q22
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE2B SPDYE6 SPDYE2	2.15e-07	12	19	3	756
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZSCAN5DP ZNF827 ZNF862 ZNF404	5.94e-03	718	19	4	28
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	SPDYE2B VIPR1 SPDYE6 SPDYE2	1.50e-04	281	21	4	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	SPDYE2B VIPR1 SPDYE6 SPDYE2	1.50e-04	281	21	4	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
Disease	Down syndrome (implicated_via_orthology)	DYRK1A DYRK1B	4.56e-05	15	20	2	DOID:14250 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	DYRK1A DYRK1B	5.21e-05	16	20	2	DOID:0050888 (implicated_via_orthology)
Disease	magnesium measurement	VIPR1 IZUMO3	9.12e-04	66	20	2	EFO_0004845
Disease	intellectual disability (implicated_via_orthology)	DYRK1A DYRK1B	1.18e-03	75	20	2	DOID:1059 (implicated_via_orthology)
Disease	HIV-1 infection	DYRK1A ZDHHC19	2.00e-03	98	20	2	EFO_0000180
Disease	longevity	DYRK1A IZUMO3	1.56e-02	284	20	2	EFO_0004300
Disease	mean reticulocyte volume	DNAH2 DYRK1A OR10X1	1.60e-02	799	20	3	EFO_0010701

Protein segments in the cluster

Peptide	Gene	Start	Entry
MKLLHVFLLFLCFHL	CFI	1	P05156
AKHRLLFFKHRLQCM	B4GALNT1	516	Q00973
MFQLLRGLAYCHHRK	CDK18	246	Q07002
IVHLKRHFMFRNHLC	DYRK1A	221	Q13627
LKRHFMFRNHLCLVF	DYRK1B	176	Q9Y463
RPNLVKHFFCHMLAV	OR10X1	186	Q8NGY0
HRLNHFFCEMPVFLK	OR2Y1	171	Q8NGV0
LFRHMFYCKHVERQL	TUBGCP2	641	Q9BSJ2
LFLRKLHCTRNYIHM	GLP2R	201	O95838
RHKLLFSFHMCAKIL	DNAH2	3681	Q9P225
YLLFIIEHCIRMFKH	SLC39A10	506	Q9ULF5
AVLLFHFCIFHRRKM	IZUMO3	191	Q5VZ72
IVLFQKRRFHFFCSM	SPDYE2B	356	A6NHP3
LFRKLHCTRNYIHMH	VIPR1	166	P32241
RFNRMFSLKCHKRSH	ZSCAN5DP	416	P0CG00
IVLFQKRRFHFFCSM	SPDYE2	356	Q495Y8
IVLFQKRRFHFFCSM	SPDYE6	356	P0CI01
LMRGFHFVKFCHFLL	ZNF862	831	O60290
TFRLYRHMCLHQKIH	ZNF404	251	Q494X3
FSLKLHMRCHQHFLR	ZNF827	446	Q17R98
HRNFRFFMLLVLSLC	ZDHHC19	151	Q8WVZ1
AFAFHLRVLAHMLRA	SLX1A	106	Q9BQ83
ILCIHLKRFRHELMF	USP33	611	Q8TEY7