Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

7.50e-1081365GO:0033695
GeneOntologyMolecularFunctioncaffeine oxidase activity

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

7.50e-1081365GO:0034875
GeneOntologyMolecularFunctionestrogen 16-alpha-hydroxylase activity

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

6.09e-09111365GO:0101020
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

2.59e-08141365GO:0008401
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

3.87e-08151365GO:0016725
GeneOntologyMolecularFunctiontestosterone 16-alpha-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

1.23e-0641363GO:0008390
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

2.01e-06311365GO:0008327
GeneOntologyMolecularFunctiontestosterone 6-beta-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

3.06e-0651363GO:0050649
GeneOntologyMolecularFunctionvitamin D 23-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

3.06e-0651363GO:0062179
GeneOntologyMolecularFunction1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

3.06e-0651363GO:0062181
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

3.23e-06341365GO:0008395
GeneOntologyMolecularFunctionaromatase activity

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

3.75e-06351365GO:0070330
GeneOntologyMolecularFunctionvitamin D3 25-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

6.09e-0661363GO:0030343
GeneOntologyMolecularFunctionvitamin D 24-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

6.09e-0661363GO:0070576
GeneOntologyMolecularFunctionATP-dependent protein disaggregase activity

HSPA1A HSPA1B HSPA8

6.09e-0661363GO:0140545
GeneOntologyMolecularFunctionC3HC4-type RING finger domain binding

HSPA1A HSPA1B HSPA8

6.09e-0661363GO:0055131
GeneOntologyMolecularFunctionvitamin D 25-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

1.06e-0571363GO:0070643
GeneOntologyMolecularFunctionestrogen 2-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

1.69e-0581363GO:0101021
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

2.04e-05491365GO:0016712
GeneOntologyMolecularFunctionmetallodipeptidase activity

ACE CNDP2 CNDP1

3.58e-05101363GO:0070573
GeneOntologyMolecularFunction(R)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

4.60e-0521362GO:0052741
GeneOntologyMolecularFunction(S)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

4.60e-0521362GO:0018675
GeneOntologyMolecularFunction(S)-limonene 7-monooxygenase activity

CYP2C19 CYP2C9

4.60e-0521362GO:0018676
GeneOntologyMolecularFunctionlimonene monooxygenase activity

CYP2C19 CYP2C9

4.60e-0521362GO:0019113
GeneOntologyMolecularFunctioncadherin binding

PUF60 LARP1 CC2D1A NIBAN2 DCHS1 KDR HSPA1A HCFC1 HSPA8 NOTCH3

1.12e-0433913610GO:0045296
GeneOntologyMolecularFunctionprotein-containing complex destabilizing activity

HSPA1A HSPA1B HSPA8

1.32e-04151363GO:0140776
GeneOntologyMolecularFunctiondenatured protein binding

HSPA1A HSPA1B

1.38e-0431362GO:0031249
GeneOntologyMolecularFunctiondipeptidase activity

ACE CNDP2 CNDP1

2.34e-04181363GO:0016805
GeneOntologyMolecularFunctionarachidonate 11,12-epoxygenase activity

CYP2C19 CYP2C9

2.74e-0441362GO:0008405
GeneOntologyMolecularFunctionlinoleic acid epoxygenase activity

CYP2C19 CYP2C9

2.74e-0441362GO:0071614
GeneOntologyMolecularFunctionfatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

4.54e-0451362GO:0120502
GeneOntologyMolecularFunctionlong-chain fatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

4.54e-0451362GO:0120319
GeneOntologyMolecularFunctiondeath receptor agonist activity

HSPA1A HSPA1B

4.54e-0451362GO:0038177
GeneOntologyMolecularFunctionarachidonate 14,15-epoxygenase activity

CYP2C19 CYP2C9

4.54e-0451362GO:0008404
GeneOntologyMolecularFunctionmonooxygenase activity

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.15e-031151365GO:0004497
GeneOntologyMolecularFunctionoxygen binding

CYP2C19 CYP3A4 CYP3A5

2.03e-03371363GO:0019825
GeneOntologyMolecularFunctionpotassium channel inhibitor activity

NEDD4L WNK1

2.43e-03111362GO:0019870
GeneOntologyMolecularFunctionATP-dependent protein folding chaperone

HSPA1A HSPA1B HSPA8

2.54e-03401363GO:0140662
GeneOntologyMolecularFunctioncell adhesion molecule binding

PUF60 LARP1 CC2D1A NIBAN2 KIRREL3 DCHS1 KDR HSPA1A HCFC1 HSPA8 NOTCH3

2.67e-0359913611GO:0050839
GeneOntologyMolecularFunctiontype II transforming growth factor beta receptor binding

TGFB1 TGFBR3

2.91e-03121362GO:0005114
GeneOntologyMolecularFunctionstructural constituent of synapse

SHANK1 ACTL9 BSN

2.92e-03421363GO:0098918
GeneOntologyMolecularFunctiondemethylase activity

CYP3A4 CYP3A5 CYP3A43

3.34e-03441363GO:0032451
GeneOntologyMolecularFunctionheme binding

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

4.10e-031541365GO:0020037
GeneOntologyMolecularFunctioncarboxypeptidase activity

ACE CNDP2 CNDP1

4.53e-03491363GO:0004180
GeneOntologyBiologicalProcessoxidative demethylation

CYP2C9 CYP3A4 CYP3A5 CYP3A43

8.10e-07121344GO:0070989
GeneOntologyBiologicalProcessalkaloid catabolic process

CYP3A4 CYP3A5 CYP3A43

2.66e-0651343GO:0009822
GeneOntologyBiologicalProcessxenobiotic catabolic process

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

3.96e-06371345GO:0042178
GeneOntologyBiologicalProcessmonoterpenoid metabolic process

CYP2C19 CYP2C9 CYP3A4

5.29e-0661343GO:0016098
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

9.51e-06441345GO:0006346
GeneOntologyBiologicalProcessdemethylation

CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.64e-05241344GO:0070988
GeneOntologyBiologicalProcessalkaloid metabolic process

CYP3A4 CYP3A5 CYP3A43

2.19e-0591343GO:0009820
GeneOntologyBiologicalProcesslipid hydroxylation

CYP3A4 CYP3A5 CYP3A43

2.19e-0591343GO:0002933
GeneOntologyBiologicalProcessfacultative heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

2.88e-05551345GO:0140718
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

MBD3L5 MBD3L2 PATZ1 CC2D1A MBD3L3 MBD3L4 PRDM2 MBD3L2B TGFB1 MSX2 ZNF469 TLE4 INSM2 SLA2 ZFHX3 HSPA1A HCFC1 NOTCH3

1.62e-04105313418GO:0000122
GeneOntologyCellularComponentinhibin-betaglycan-ActRII complex

INHA TGFBR3

1.29e-0431382GO:0034673
DomainMeCpG-bd_2/3_C_dom

MBD3L5 MBD3L2 MBD3L3 MBD3L4

8.21e-0871324IPR025884
DomainMBD2/MBD3_p55-bd

MBD3L5 MBD3L2 MBD3L3 MBD3L4

8.21e-0871324IPR032343
DomainMBDa

MBD3L5 MBD3L2 MBD3L3 MBD3L4

8.21e-0871324PF16564
DomainMBD_C

MBD3L5 MBD3L2 MBD3L3 MBD3L4

8.21e-0871324PF14048
DomainCyt_P450_E_grp-II

CYP3A4 CYP3A5 CYP3A43

3.42e-0651323IPR002402
DomainCyt_P450_E_CYP3A

CYP3A4 CYP3A5 CYP3A43

6.80e-0661323IPR008072
DomainCyt_P450_CS

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

3.57e-05531325IPR017972
DomainCNDP/DUG1

CNDP2 CNDP1

4.96e-0521322IPR017153
DomainCYTOCHROME_P450

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

5.10e-05571325PS00086
Domain-

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

5.55e-055813251.10.630.10
Domainp450

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

5.55e-05581325PF00067
DomainCyt_P450

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

6.54e-05601325IPR001128
DomainARGE_DAPE_CPG2_1

CNDP2 CNDP1

1.48e-0431322PS00758
DomainARGE_DAPE_CPG2_2

CNDP2 CNDP1

1.48e-0431322PS00759
DomainArgE/DapE_CS

CNDP2 CNDP1

1.48e-0431322IPR001261
DomainHSP70

HSPA1A HSPA1B HSPA8

1.81e-04161323PF00012
DomainHSP70_2

HSPA1A HSPA1B HSPA8

2.18e-04171323PS00329
DomainHSP70_1

HSPA1A HSPA1B HSPA8

2.18e-04171323PS00297
DomainHSP70_3

HSPA1A HSPA1B HSPA8

2.18e-04171323PS01036
DomainHsp_70_fam

HSPA1A HSPA1B HSPA8

2.61e-04181323IPR013126
DomainCyt_P450_E_grp-I

CYP2C19 CYP2C9 CYP3A5 CYP3A43

2.84e-04451324IPR002401
DomainVWFA

VWA3A COL6A3 VWA8 COL20A1 HMCN2

2.88e-04821325PS50234
DomainVWA

VWA3A COL6A3 VWA8 COL20A1 HMCN2

3.23e-04841325SM00327
DomainZINC_FINGER_C2H2_2

ZNF142 ZNF843 SALL3 PATZ1 ADNP2 ZNF831 PRDM2 ZNF469 MTF1 SP6 INSM2 ZFHX3 ZC3H7B ZBTB3 ZNF687

3.84e-0477513215PS50157
DomainZINC_FINGER_C2H2_1

ZNF142 ZNF843 SALL3 PATZ1 ADNP2 ZNF831 PRDM2 ZNF469 MTF1 SP6 INSM2 ZFHX3 ZC3H7B ZBTB3 ZNF687

3.95e-0477713215PS00028
Domain-

CNDP2 CNDP1

4.89e-04513223.30.70.360
DomainM20_dimer

CNDP2 CNDP1

4.89e-0451322PF07687
DomainPeptidase_M20_dimer

CNDP2 CNDP1

4.89e-0451322IPR011650
DomainPeptidase_M20

CNDP2 CNDP1

4.89e-0451322PF01546
DomainPeptidase_M20

CNDP2 CNDP1

4.89e-0451322IPR002933
DomainZnf_C2H2-like

ZNF142 ZNF843 SALL3 PATZ1 ADNP2 ZNF831 PRDM2 ZNF469 MTF1 SP6 INSM2 ZFHX3 ZC3H7B ZBTB3 ZNF687

5.08e-0479613215IPR015880
DomainZnf_C2H2

ZNF142 ZNF843 SALL3 PATZ1 ADNP2 ZNF831 PRDM2 ZNF469 MTF1 SP6 INSM2 ZFHX3 ZC3H7B ZBTB3 ZNF687

5.70e-0480513215IPR007087
DomainZnF_C2H2

ZNF142 ZNF843 SALL3 PATZ1 ADNP2 ZNF831 PRDM2 ZNF469 MTF1 SP6 INSM2 ZFHX3 ZC3H7B ZBTB3 ZNF687

5.93e-0480813215SM00355
DomainVWA

VWA3A COL6A3 VWA8 COL20A1

6.59e-04561324PF00092
DomainVWF_A

VWA3A COL6A3 VWA8 COL20A1 HMCN2

6.87e-04991325IPR002035
DomainAT_hook

PATZ1 SRCAP PRR12

8.91e-04271323SM00384
DomainAT_hook_DNA-bd_motif

PATZ1 SRCAP PRR12

8.91e-04271323IPR017956
DomainZnf_C2H2/integrase_DNA-bd

ZNF142 ZNF843 SALL3 PATZ1 ZNF831 PRDM2 ZNF469 MTF1 SP6 INSM2 ZFHX3 ZBTB3 ZNF687

1.28e-0369413213IPR013087
PathwayREACTOME_XENOBIOTICS

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

2.60e-0723885M5372
PathwayREACTOME_XENOBIOTICS

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

4.07e-0725885MM14846
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2C19 CYP3A4 CYP3A5 CYP3A43

6.75e-0712884MM15616
PathwayKEGG_LINOLEIC_ACID_METABOLISM

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

8.92e-0729885M2920
PathwayWP_TAMOXIFEN_METABOLISM

CYP2C19 CYP2C9 CYP3A4 CYP3A5

7.82e-0621884M39631
PathwayREACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS

CYP2C19 CYP3A4 CYP3A5 CYP3A43

9.52e-0622884MM15614
PathwayBIOCARTA_ACETAMINOPHEN_PATHWAY

CYP3A4 CYP3A5 CYP3A43

1.29e-058883MM1547
PathwayWP_ESTROGEN_METABOLISM_WP5276

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.37e-0524884M46445
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.92e-0531884M39476
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

4.13e-0562885M39653
PathwayWP_PREGNANE_X_RECEPTOR_PATHWAY

CYP2C19 CYP2C9 CYP3A4 CYP3A5

4.46e-0532884M39567
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

4.82e-0564885M5650
PathwayKEGG_RETINOL_METABOLISM

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

4.82e-0564885M9488
PathwayWP_OCTADECANOID_FORMATION_FROM_LINOLEIC_ACID

CYP2C19 CYP2C9 CYP3A4

4.97e-0512883M48064
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

5.60e-0566885MM14839
PathwayREACTOME_ATTENUATION_PHASE

HSPA1A HSPA1B HSPA8

6.43e-0513883MM14952
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

7.43e-0570885M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

8.51e-0572885M9257
PathwayREACTOME_ATORVASTATIN_ADME

CYP3A4 CYP3A5 CYP3A43

1.01e-0415883MM15697
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

CYP2C19 CYP2C9 CYP3A4 CYP3A5 IL17B TGFB1 TGFBR3 HSPA1A SLC39A5

1.47e-04314889M39428
PathwayREACTOME_ASPIRIN_ADME

CYP2C19 CYP3A4 CYP3A5 CYP3A43

1.74e-0445884MM15694
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP3A4 CYP3A5 CYP3A43

1.79e-0418883MM14843
PathwayREACTOME_SIGNALING_BY_TGFBR3

INHA TGFB1 TGFBR3

2.88e-0421883MM17231
PathwayREACTOME_AUF1_HNRNP_D0_BINDS_AND_DESTABILIZES_MRNA

PSMF1 HSPA1A HSPA1B HSPA8

3.79e-0455884MM15137
PathwayREACTOME_PREDNISONE_ADME

CYP3A4 CYP3A5 CYP3A43

3.80e-0423883MM16639
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

HSPA1A HSPA1B HSPA8

3.80e-0423883MM14953
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

4.78e-04104885M738
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

TFE3 TGFB1 ADAMTS10 TGFBR3

4.97e-0459884M39886
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

5.00e-04105885MM14842
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

CYP3A4 CYP3A5 CYP3A43

5.51e-0426883MM15190
PathwayREACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION

TGFB1 ZFHX3

5.69e-046882MM15534
PathwayREACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS

CYP2C9 CYP3A4

5.69e-046882M27909
PathwayREACTOME_ATTENUATION_PHASE

HSPA1A HSPA1B HSPA8

6.88e-0428883M27254
PathwayWP_CANNABINOID_RECEPTOR_SIGNALING

CYP2C19 CYP2C9 CYP3A4

7.64e-0429883M39676
PathwayREACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION

TGFB1 ZFHX3

7.93e-047882M27807
PathwayREACTOME_DRUG_ADME

CYP2C19 CYP3A4 CYP3A5 CYP3A43 CNDP2

8.83e-04119885MM15692
PathwayREACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING

GBF1 IGF2R AP1B1 HSPA8

1.00e-0371884MM14787
PathwayWP_VITAMIN_D_RECEPTOR_PATHWAY

CA9 CYP2C9 CYP3A4 CYP3A5 IRF5 TGFB1

1.05e-03185886M39718
PathwayREACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING

TGFB1 TGFBR3

1.05e-038882M48252
PathwayREACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING

TGFB1 TGFBR3

1.05e-038882MM17233
PathwayREACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET

CYP2C19 CYP2C9

1.05e-038882M27135
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2C9 CYP3A4

1.05e-038882M27891
PathwayREACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING

GBF1 IGF2R AP1B1 HSPA8

1.06e-0372884M539
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

NUP155 HSPA1A HSPA1B HSPA8

1.11e-0373884MM14948
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP3A4 CYP3A5 CYP3A43

1.12e-0333883MM1448
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP2C19 CYP2C9

1.35e-039882M27143
PathwayWP_NEOVASCULARIZATION_PROCESSES

TGFB1 KDR NOTCH3

1.57e-0337883M39506
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

HSPA1A HSPA1B HSPA8

1.69e-0338883M27255
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

NUP155 HSPA1A HSPA1B HSPA8

1.71e-0382884M27250
PathwayREACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS

PSMF1 HSPA1A HSPA1B HSPA8

2.04e-0386884MM15140
PathwayREACTOME_CYP2E1_REACTIONS

CYP2C19 CYP2C9

2.04e-0311882M27130
PathwayWP_ALANINE_AND_ASPARTATE_METABOLISM

GPT AGXT

2.44e-0312882M39331
PathwayWP_IRINOTECAN_PATHWAY

CYP3A4 CYP3A5

2.44e-0312882M39611
PathwayWP_BIOMARKERS_FOR_UREA_CYCLE_DISORDERS

GPT NAGS

2.44e-0312882M39842
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43 CNDP2

2.47e-03219886MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43 CNDP2

2.52e-03220886M10320
PathwayREACTOME_ASPIRIN_ADME

CYP2C19 CYP2C9 CYP3A4

2.59e-0344883M45014
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

NUP155 HSPA1A HSPA1B HSPA8

2.61e-0392884MM14951
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

GBF1 PCNX3 SZT2 VWA8 PUF60 GTSE1 CC2D1A IRF5 SRCAP MBD6 WNK1 ADGRA2 DENND1A TFE3 PRR12 MSX2 SCAF1 IGF2R KCNK5 RIC8A ZC3H7B HCFC1 TRAPPC9 ABCC10 RAI1 TBCD ZNF687

5.68e-1411051412735748872
Pubmed

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.02e-125141518156313
Pubmed

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

6.10e-126141512504854
Pubmed

Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

6.10e-12614158043019
Pubmed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

6.10e-126141518942147
Pubmed

Identification and characterization of human FNBP3 gene in silico.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

5.66e-118141512964049
Pubmed

Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirements.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.59e-104141418021343
Pubmed

Frequency of CYP3A4, CYP3A5, CYP2C9, and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.59e-104141419337788
Pubmed

CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.29e-095141420833683
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

GTSE1 LARP1 CC2D1A TACC2 NIBAN2 WNK1 GORASP2 FAM83G HSPA1A HSPA1B HCFC1 TP53BP1 MRTFA ZNF687 RAVER1

2.38e-095031411516964243
Pubmed

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

2.96e-0915141515701600
Pubmed

Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.86e-096141417900275
Pubmed

Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.86e-096141419934793
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

6.07e-0917141527197076
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.51e-082014159890157
Pubmed

A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.79e-088141420147896
Pubmed

Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.21e-089141419350405
Pubmed

ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.21e-089141417178267
Pubmed

Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.21e-089141418496131
Pubmed

Perioperative genomic profiles using structure-specific oligonucleotide probes.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 ACE

3.24e-0823141519474452
Pubmed

Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

5.33e-0810141420235787
Pubmed

Pharmacogenetically relevant polymorphisms in Portugal.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

5.33e-0810141418240903
Pubmed

Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141323846873
Pubmed

Intergenic mRNA molecules resulting from trans-splicing.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141311726664
Pubmed

Electrophoretic and immunocytochemical analysis of Hsp72 and Hsp73 expression in heat-stressed mouse testis and epididymis.

HSPA1A HSPA1B HSPA8

6.52e-083141323352621
Pubmed

High fat diet induced obesity is mitigated in Cyp3a-null female mice.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141329738703
Pubmed

A novel female-specific member of the CYP3A gene subfamily in the mouse liver.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141310775455
Pubmed

Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141319226368
Pubmed

Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions.

INHA TGFB1 TGFBR3

6.52e-083141316621788
Pubmed

Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141337258238
Pubmed

Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141328567424
Pubmed

A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141325005602
Pubmed

Lack of association between genetic polymorphisms of CYP3A4, CYP2C9 and CYP2C19 and antituberculosis drug-induced liver injury in a community-based Chinese population.

CYP2C19 CYP2C9 CYP3A4

6.52e-083141323469989
Pubmed

Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141321081028
Pubmed

Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.

CYP3A4 CYP3A5 CYP3A43

6.52e-08314139143324
Pubmed

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro.

CYP2C19 CYP2C9 CYP3A4

6.52e-083141337584614
Pubmed

CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141321148252
Pubmed

Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic cytochrome P450 3A, a drug-metabolizing enzyme.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141323370405
Pubmed

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.

CYP2C19 CYP2C9 CYP3A4

6.52e-083141321692828
Pubmed

Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141326212543
Pubmed

Association of genetic polymorphisms with warfarin dose requirements in Chinese patients.

CYP2C19 CYP2C9 GGCX

6.52e-083141323941071
Pubmed

Hepatotoxicity of oral and intravenous voriconazole in relation to cytochrome P450 polymorphisms.

CYP2C19 CYP2C9 CYP3A5

6.52e-083141317827141
Pubmed

Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141312147261
Pubmed

Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.

CYP3A4 CYP3A5 CYP3A43

6.52e-08314131339292
Pubmed

Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141312617959
Pubmed

Variability in human drug metabolizing cytochrome P450 CYP2C9, CYP2C19 and CYP3A5 activities caused by genetic variations in cytochrome P450 oxidoreductase.

CYP2C19 CYP2C9 CYP3A5

6.52e-083141331128914
Pubmed

Stored of Hsp72/Hsp73 in germinal vesicle-stage mouse oocytes.

HSPA1A HSPA1B HSPA8

6.52e-083141315129916
Pubmed

Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141319188337
Pubmed

Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.

CYP2C19 CYP3A4 CYP3A5

6.52e-083141318394438
Pubmed

Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141311284050
Pubmed

Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141314733933
Pubmed

Effects of CYP2C19, CYP2C9 and CYP3A4 gene polymorphisms on plasma voriconazole levels in Chinese pediatric patients.

CYP2C19 CYP2C9 CYP3A4

6.52e-083141335081606
Pubmed

Functional analysis of HSPA1A and HSPA8 in parturition.

HSPA1A HSPA1B HSPA8

6.52e-083141328025138
Pubmed

Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141322291988
Pubmed

CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.

CYP3A4 CYP3A5 CYP3A43

6.52e-083141315548719
Pubmed

Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol.

CYP3A4 CYP3A5 CYP3A43

6.52e-08314132402224
Pubmed

Genetic analysis of sensitization and tolerance to cocaine.

CYP3A4 CYP3A5 CYP3A43

6.52e-08314137932176
Pubmed

VARIANTS OF THE FORMATION AND COURSE OF DRUG-RESISTANT EPILEPSY IN CHILDREN WITH GENETIC POLYMORPHISMS OF CYP2C9, CYP2C19, CYP3A4.

CYP2C19 CYP2C9 CYP3A4

6.52e-083141337326083
Pubmed

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

8.36e-0811141415469410
Pubmed

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

8.36e-0811141415039299
Pubmed

Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.34e-0730141520529763
Pubmed

Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.80e-0713141419696793
Pubmed

Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.80e-0713141416771603
Pubmed

Influence of ethnicity on pharmacogenetic variation in the Ghanaian population.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.80e-0713141419546880
Pubmed

Toward personalized medicine in renal transplantation.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.51e-0714141420970553
Pubmed

A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver.

CYP3A4 CYP3A5 CYP3A43

2.60e-07414137813478
Pubmed

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141317975676
Pubmed

The high prevalence of the poor and ultrarapid metabolite alleles of CYP2D6, CYP2C9, CYP2C19, CYP3A4, and CYP3A5 in Taiwanese population.

CYP2C19 CYP2C9 CYP3A4

2.60e-074141316924387
Pubmed

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141327638959
Pubmed

Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141323709690
Pubmed

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141326903378
Pubmed

iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141332130917
Pubmed

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis.

CYP2C19 CYP2C9 CYP3A5

2.60e-074141315248218
Pubmed

CYP3A4 and pregnane X receptor humanized mice.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141317936928
Pubmed

Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia.

HSPA1A HSPA1B HSPA8

2.60e-074141318299791
Pubmed

Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population.

CYP2C19 CYP2C9 CYP3A5

2.60e-074141317635181
Pubmed

Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients.

CYP2C19 CYP3A4 CYP3A5

2.60e-074141317922881
Pubmed

Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141310230766
Pubmed

Upregulation of the constitutively expressed HSC70 by KLF4.

HSPA1A HSPA1B HSPA8

2.60e-074141318379898
Pubmed

Mouse aortic muscle cells respond to oxygen following cytochrome P450 3A13 gene transfer.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141323656416
Pubmed

A map of the mouse Cyp3a locus.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141314509827
Pubmed

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141323125282
Pubmed

Hepatocyte nuclear factor 4α regulates expression of the mouse female-specific Cyp3a41 gene in the liver.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141321088200
Pubmed

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141336050438
Pubmed

Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141331633069
Pubmed

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141310935643
Pubmed

Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141312958193
Pubmed

Characterization of CYP1A2, CYP2C19, CYP3A4 and CYP3A5 polymorphisms in South Brazilians.

CYP2C19 CYP3A4 CYP3A5

2.60e-074141324443221
Pubmed

Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure.

HSPA1A HSPA1B HSPA8

2.60e-074141322956628
Pubmed

Analysis of CYP450 gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.

CYP2C9 CYP3A4 CYP3A5

2.60e-074141332279544
Pubmed

Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141325319358
Pubmed

The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice.

CYP3A4 CYP3A5 CYP3A43

2.60e-074141330796914
Pubmed

Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).

CYP3A4 CYP3A5 CYP3A43

2.60e-07414137803471
Pubmed

Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.

CYP2C19 CYP2C9 CYP3A4 CYP3A5 ACE TGFB1 KDR

5.30e-07117141718996102
Pubmed

Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women.

CYP2C19 CYP2C9 CYP3A4 CYP3A5

5.91e-0717141419424794
Pubmed

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

CYP3A4 CYP3A5 CYP3A43

6.48e-075141311266076
Pubmed

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

CYP3A4 CYP3A5 CYP3A43

6.48e-075141319920203
Pubmed

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

CYP3A4 CYP3A5 CYP3A43

6.48e-075141323090875
Pubmed

Association of cyclophosphamide pharmacokinetics to polymorphic cytochrome P450 2C19.

CYP2C19 CYP2C9 CYP3A5

6.48e-075141316116487
Pubmed

A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing.

HSPA1A HSPA1B HSPA8

6.48e-075141311584023
InteractionTOP3B interactions

GBF1 PCNX3 SZT2 VWA8 PUF60 GTSE1 CC2D1A IRF5 SRCAP MBD6 WNK1 ADGRA2 DENND1A TFE3 PRR12 MSX2 SCAF1 GORASP2 IGF2R KCNK5 RIC8A ZC3H7B HCFC1 TRAPPC9 ABCC10 TP53BP1 RAI1 TBCD ZNF687

1.31e-07147013629int:TOP3B
InteractionCYP3A4 interactions

CYP2C9 CYP3A4 CYP3A5 HSPA8

4.41e-06171364int:CYP3A4
Cytoband19p13.2

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B ADAMTS10 ACTL9 RAVER1

6.07e-07229141819p13.2
Cytoband7q21.1

CYP3A4 CYP3A5 CYP3A43

1.57e-06814137q21.1
CytobandEnsembl 112 genes in cytogenetic band chr19p13

MBD3L5 PODNL1 MBD3L2 CC2D1A MBD3L3 MBD3L4 MBD3L2B ADAMTS10 ACTL9 NOTCH3 IL27RA RAVER1

7.14e-0679714112chr19p13
Cytoband10q24

CYP2C19 CYP2C9 GBF1

1.73e-0435141310q24
Cytoband18q22.3

CNDP2 CNDP1

9.58e-0415141218q22.3
GeneFamilyCytochrome P450 family 3

CYP3A4 CYP3A5 CYP3A43

4.77e-0688131002
GeneFamilyHeat shock 70kDa proteins

HSPA1A HSPA1B HSPA8

5.63e-0517813583
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

SDK2 ISLR KIRREL3 HMCN2 KDR

7.82e-04161815593
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 ZNF843 SALL3 PATZ1 ADNP2 ZNF469 SP6 INSM2 ZFHX3 ZBTB3

1.35e-03718811028
GeneFamilyImmunoglobulin like domain containing

SDK2 ADGRA2 KIRREL3 HMCN2 KDR

1.75e-03193815594
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ADNP2 ZFHX3

2.00e-0315812529
CoexpressionSAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

6.09e-08201415MM1104
CoexpressionGINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN

SZT2 LARP1 SRCAP MSTO1 SCAF1 ZDHHC24 KCNK5 ZC3H7B HCFC1 ABCC10 CAPN15

2.31e-0633814111M17094
CoexpressionGSE15930_NAIVE_VS_48H_IN_VITRO_STIM_CD8_TCELL_UP

GBF1 NEDD4L FRAT1 AP1B1 TLE4 HSPA1A NOTCH3 IL27RA

1.24e-051981418M3596
CoexpressionGSE1460_CD4_THYMOCYTE_VS_THYMIC_STROMAL_CELL_UP

SHANK1 PSMF1 SDK2 CYP3A4 DGKA IRF5 TRAPPC9 RAI1

1.28e-051991418M3478
CoexpressionKRISHNAN_FURIN_TARGETS_UP

HSPA1A HSPA1B HSPA8

1.78e-05101413MM1243
CoexpressionGSE15330_LYMPHOID_MULTIPOTENT_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_IKAROS_KO_UP

RNF32 NEDD4L PATZ1 TGFBR3 SLC49A4 RAI1 IL27RA

3.34e-051661417M7009
CoexpressionGSE15330_HSC_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_DN

NEDD4L DGKA LARP1 MAGI3 TGFBR3 SLC49A4 RAI1

3.61e-051681417M7007
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Adult / Lineage, Cell type, age group and donor

CYP3A5 ACE TGFBR3 SP6 KDR HSPA1A HSPA1B

2.34e-061881417e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell10x5'-blood-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|blood / Manually curated celltypes from each tissue

NACAD SP6 KCNK5 FAM83G SLA2 TP53BP1

4.79e-061361416f024015bf60e64b8657e410e24995a1edec85196
ToppCelldroplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SZT2 FRAT1 ADNP2 NIBAN2 ZDHHC24 ZBTB3

1.45e-05165141694a5211072464fc24592bb107a853ce832e816fe
ToppCellfacs-GAT-Fat-18m-Epithelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA9 ESPN GPT FAM83G INAVA SLC39A5

1.60e-051681416d6c8056b7d6b937bb91e6b33beeb1075dce1685c
ToppCellfacs-GAT-Fat-18m-Epithelial-epithelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA9 ESPN GPT FAM83G INAVA SLC39A5

1.60e-0516814167102c52bf1b2ba67bb3700932181a2e0a6627711
ToppCellfacs-GAT-Fat-18m-Epithelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA9 ESPN GPT FAM83G INAVA SLC39A5

1.60e-05168141668a2f9fd53b54023241acd1620cf24226f639c1b
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCP11L1 ZNF831 ADGRA2 KCNK5 BSN MAP4K2

1.89e-05173141612f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCellfacs-Spleen-nan-3m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKA TGFBR3 ZDHHC24 IGF2R SLA2 IL27RA

2.44e-051811416be7c7db6b99603759593e6f79cdcaa4bbf234cb7
ToppCellfacs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKA TGFBR3 ZDHHC24 IGF2R SLA2 IL27RA

2.67e-051841416c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL3 ADNP2 TUBGCP6 TGFBR3 KDR ZC3H7B

2.76e-051851416bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

PCNX3 GTSE1 NIBAN2 NUDT17 ADGRA2 SLC49A4

2.93e-0518714163c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

NEDD4L CYP3A5 ACE TGFBR3 ZFHX3 HSPA1B

3.02e-0518814161aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL6A3 TBX4 IL17B TGFBR3 ZFHX3 NOTCH3

3.11e-0518914167ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell367C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NEDD4L CYP3A5 ACE SP6 HSPA1A HSPA1B

3.49e-0519314165c6b03d6d98aa873fda1a201d44a912246bb5a92
ToppCell367C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NEDD4L CYP3A5 ACE SP6 HSPA1A HSPA1B

3.49e-051931416d4b58eee97043b4337ec36c40f9af6499d864df9
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESPN CYP3A4 CYP3A5 ACE INAVA SLC39A5

4.03e-051981416e3e2233c796d5e9051c8c1b66f70f406f048ed56
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NEDD4L MAGI3 FER1L6 SCUBE2 KDR NOTCH3

4.03e-051981416af399569c718f5fd971d73a7926768c9311002a3
ToppCellC_01|World / shred on cell type and cluster

ESPN CYP2C9 CYP3A4 CYP3A5 ACE CNDP2

4.03e-05198141671d38084d09a96331877384ce6346f0de4bdcef9
ToppCellTracheal-10x5prime-Stromal-Chondrocytic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SDK2 CYP3A43 IL17B ISLR SCUBE2 KCNK5

4.03e-051981416c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PODNL1 COL6A3 IL17B ISLR ADGRA2 NOTCH3

4.03e-051981416eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCellTracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SDK2 CYP3A43 IL17B ISLR SCUBE2 KCNK5

4.03e-05198141655f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCell3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESPN CYP3A4 CYP3A5 ACE CNDP2 SLC39A5

4.03e-0519814162967fb2d94662997bfe932ac299c80d6f182fb48
ToppCell3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESPN CYP3A4 CYP3A5 ACE CNDP2 SLC39A5

4.03e-051981416222a060c2c63d30da34e4b71c37aa27a048d7d09
ToppCell3'-Child09-12-SmallIntestine-Epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESPN CYP3A4 CYP3A5 ACE INAVA SLC39A5

4.14e-051991416043c65bdf54a1bf0e483fea9ffc042ff5b271764
ToppCellCaecum-T_cell-Th1|T_cell / Region, Cell class and subclass

DONSON TGFBR3 TLE4 HSPA1A HSPA1B HSPA8

4.14e-05199141613a80e6d3cf9c831edbe0644545071153e35f82b
ToppCellCOVID-19|World / group, cell type (main and fine annotations)

COL6A3 DONSON DENND1A HSPA1A HSPA1B HSPA8

4.26e-052001416ac38a468559c33ee00152735ce6e408f3f48df84
ToppCellSigmoid-(1)_T_cell-(18)_cycling_gd_T|Sigmoid / shred on region, Cell_type, and subtype

GBF1 CYP3A5 GTSE1 NUDT17 TUBGCP6 CCDC136

4.26e-0520014166e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCellSigmoid-T_cell-cycling_gd_T|Sigmoid / Region, Cell class and subclass

GBF1 CYP3A5 GTSE1 NUDT17 TUBGCP6 CCDC136

4.26e-0520014169769185abae084ffac36420c749625e679b70ca8
ComputationalCytochrome P450.

CYP2C19 CYP2C9 CYP3A4

1.12e-0414753MODULE_106
Drugdesmethyltrimipramine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

4.72e-0871404CID000160632
Drug16-O-demethylaconitine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

4.72e-0871404ctd:C486136
DrugVoriconazole

CYP2C19 CYP2C9 CYP3A4 CYP3A5

4.72e-0871404ctd:D065819
Drug13-hydroxyeicosatetraenoic acid

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.40e-0881404CID006439499
Drug11-HODE

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.40e-0881404CID006438497
Drug4-hydroxyalprazolam

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.40e-0881404CID000182017
Drugphenylcyclopropane

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.68e-0791404CID000070112
Drugmono-N-demethyladinazolam

CYP2C19 CYP2C9 CYP3A4

2.28e-0731403ctd:C050132
DrugDelavirdine

CYP2C19 CYP2C9 CYP3A4

2.28e-0731403ctd:D020008
DrugCelsior

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.79e-07101404ctd:C088453
Drug8-hydroxydaidzein

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.79e-07101404CID005466139
DrugAHMA

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.79e-07101404CID000216240
Drugpolybrominated biphenyl

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43 GPT

2.83e-07441406CID000042948
Drugomeprazole sulfone

CYP2C19 CYP2C9 CYP3A4 CYP3A5 AGXT

3.17e-07241405CID000145900
DrugHaloperidol metabolite I

CYP2C19 CYP2C9 CYP3A4 CYP3A5

4.37e-07111404CID000038282
Drug5-hydroxydiclofenac

CYP2C19 CYP2C9 CYP3A4 CYP3A5

6.52e-07121404CID003052566
Drug2-Tbmbfd

CYP2C19 CYP2C9 CYP3A4 CYP3A5

6.52e-07121404CID000126928
Drug4-(N-propionylanilino)piperidine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

6.52e-07121404CID000259381
Drugnorclozapine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

6.52e-07121404ctd:C058272
Drug1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea

CYP2C19 CYP2C9 CYP3A4

9.06e-0741403ctd:C558737
Drughydroxytrimipramine

CYP2C19 CYP3A4 CYP3A5

9.06e-0741403CID000160610
Drugrabeprazole-thioether

CYP2C19 CYP2C9 CYP3A4

9.06e-0741403ctd:C523099
Drug5-methoxyflavone

CYP2C9 CYP3A4 CYP3A5

9.06e-0741403CID000094525
DrugN-ethyl-3-toluamide

CYP2C19 CYP3A4 CYP3A5

9.06e-0741403ctd:C454678
DrugAC1L18GM

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.38e-07131404CID000000092
Drug1'-hydroxymidazolam

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.38e-07131404CID000107917
Drugclozapine N-oxide

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.38e-07131404CID000036727
Drug5-hydroxyomeprazole

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.38e-07131404CID000119560
Drugpropionanilide

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.31e-06141404CID000012107
Drugcarboxytolbutamide

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.31e-06141404CID000159651
DrugBP-7,8-oxide

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.44e-06321405CID000037455
Drug2'-(glutathion-S-yl)-deschlorodiclofenac

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.77e-06151404ctd:C586542
Drug4-hydroxymephenytoin

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.77e-06151404CID000119507
DrugN-desethyloxybutynin

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.77e-06151404CID000133577
Drug2-oxo-clopidogrel

CYP2C19 CYP2C9 CYP3A4

2.26e-0651403ctd:C540904
Drugbenfuracarb

CYP2C19 CYP2C9 CYP3A4

2.26e-0651403ctd:C096128
Drugmono(2-ethyl-5-hydroxyhexyl) phthalate

CYP2C19 CYP2C9 CYP3A4

2.26e-0651403ctd:C479069
Drugpantoprazole

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

2.29e-06351405CID000004679
DrugAC1L1CJI

CYP2C9 CYP3A4 CYP3A5 CYP3A43 ACE

2.29e-06351405CID000001929
DrugHCFC-141b

CYP2C19 CYP3A4 CYP3A5 HCFC1

2.35e-06161404CID000015586
Drug6-hydroxychlorzoxazone

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.35e-06161404CID000002734
Drugdesmethylazelastine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.35e-06161404CID000162558
Drug1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane

CYP2C19 CYP2C9 CYP3A4 CYP3A5

2.35e-06161404ctd:C495657
Drugdiosmetin

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.06e-06171404ctd:C039602
Drugpiperonyl butoxide

CYP2C19 CYP2C9 CYP3A5 CYP3A43 GPT KDR

3.56e-06671406CID000005794
Drugmenthofuran

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.92e-06181404CID000329983
DrugAzamulinum

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.92e-06181404CID003086060
Drug7-benzyloxyquinoline

CYP2C19 CYP2C9 CYP3A4 CYP3A5

3.92e-06181404CID003035604
Drughydrocotarnine

CYP2C9 CYP3A4 CYP3A5

4.49e-0661403CID000003646
Drug4'-methoxyflavone

CYP2C9 CYP3A4 CYP3A5

4.49e-0661403CID000077793
Drug4,4'-cyclohexylidenebisphenol

CYP2C19 CYP2C9 CYP3A4

4.49e-0661403ctd:C570106
Drugdroloxifene

CYP3A4 CYP3A5 TGFB1

4.49e-0661403ctd:C038345
Drugavasimibe

CYP2C19 CYP2C9 CYP3A4

4.49e-0661403ctd:C423185
Drugmono(2-ethyl-5-oxohexyl)phthalate

CYP2C19 CYP2C9 CYP3A4

4.49e-0661403ctd:C080276
DrugAC1O5Z5L

CYP2C19 CYP2C9 CYP3A4

4.49e-0661403CID006443527
DrugCyclodextrins

CYP2C19 CYP2C9 CYP3A4

4.49e-0661403ctd:D003505
Drugmepirodipine

CYP2C19 CYP2C9 CYP3A4

4.49e-0661403ctd:C050699
Drughydroxytolbutamide

CYP2C19 CYP2C9 CYP3A4 CYP3A5

4.94e-06191404CID000003656
Drug6|A-Hydroxycortisol

CYP2C19 CYP2C9 CYP3A4 CYP3A5

4.94e-06191404CID000150985
Drugrabeprazole

CYP2C19 CYP3A4 CYP3A5 CYP3A43

4.94e-06191404CID000005029
Drugdiethylnitrosamine

CYP2C19 CYP2C9 CYP3A4 CYP3A5 TGFB1 IGF2R HCFC1

5.70e-061111407CID000005921
DrugN'-nitrosoanatabine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

6.15e-06201404CID000051291
DrugNSC76436

CYP2C19 CYP2C9 CYP3A4 AGXT

6.15e-06201404CID000002828
Drug3C etc

CYP2C19 CYP2C9 CYP3A4 CYP3A5

6.15e-06201404CID000164045
Drug3-methoxymorphinan

CYP2C19 CYP2C9 CYP3A4 CYP3A5

6.15e-06201404CID000001671
DrugN-benzylformamide

CYP2C19 CYP2C9 CYP3A4 GPT ACE NOTCH3

7.45e-06761406CID000080654
DrugAC1L21VM

CYP2C19 CYP2C9 CYP3A4 CYP3A5

7.56e-06211404CID000039524
Drugnirvanol

CYP2C19 CYP2C9 CYP3A4 CYP3A5

7.56e-06211404CID000091480
Drug5-n-butyl-pyrazolo(1,5-a)pyrimidine

CYP2C19 CYP2C9 CYP3A4

7.82e-0671403ctd:C547858
Drug4-(4-chlorobenzyl)pyridine

CYP2C9 CYP3A4 CYP3A5

7.82e-0671403CID000078124
Drug5-hydroxydiclofenac

CYP2C19 CYP3A4 CYP3A5

7.82e-0671403ctd:C117715
Drugnorfluoxetine

CYP2C9 CYP3A4 CYP3A5

7.82e-0671403ctd:C036139
Drugquinidine-N-oxide

CYP2C19 CYP2C9 CYP3A4

7.82e-0671403CID000050979
Drug12-hydroxyellipticine

CYP2C19 CYP2C9 CYP3A4

7.82e-0671403ctd:C517214
Drug6-Fluoro-6-desoxyoxymorphone

CYP2C19 CYP2C9 CYP3A4

7.82e-0671403CID005486899
DrugN'-nitrosoanabasine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

9.19e-06221404CID000014335
Drugperazine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.11e-05231404CID000004744
DrugYM-09730-5

CYP2C19 CYP2C9 CYP3A4 ACE

1.11e-05231404CID000002296
Drug3'-amino-3'-deoxythymidine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.11e-05231404CID000108074
DrugHCFC-123

CYP2C19 CYP3A4 CYP3A5 GPT

1.11e-05231404CID000009385
Drug2cgu

CYP2C19 CYP2C9 CYP3A4 CYP3A5 HSPA8

1.13e-05481405CID003506204
Drugnitro-L

CYP2C9 CYP3A4 CYP3A5 CYP3A43 GPT

1.13e-05481405CID000006849
Drugretrorsine

CYP2C19 CYP3A4 GPT

1.25e-0581403ctd:C003300
Drugnafimidone

CYP2C9 CYP3A4 CYP3A5

1.25e-0581403CID000051199
Drugbifendate

CYP3A4 GPT AGXT

1.25e-0581403CID000108213
DrugAC1L4AGK

CYP2C19 CYP2C9 CYP3A4

1.25e-0581403CID000182186
Drug11 beta-hydroxytestosterone

CYP2C19 CYP2C9 CYP3A4

1.25e-0581403CID000114920
Drugprecocene I

CYP3A4 CYP3A5 GPT

1.25e-0581403CID000028619
Drug1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid

CYP2C19 CYP2C9 CYP3A4

1.25e-0581403ctd:C585955
DrugABT-761

CYP2C9 CYP3A4 CYP3A5

1.25e-0581403CID003086671
Drugterritrem A

CYP2C9 CYP3A4 CYP3A5

1.25e-0581403CID000115079
Drugdesmethylmaprotiline

CYP2C19 CYP2C9 CYP3A4

1.25e-0581403CID000119409
Druggermacrone

CYP2C19 CYP2C9 CYP3A4

1.25e-0581403ctd:C048393
Drug19-HETE

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.26e-05491405CID006439528
DrugKW-3049

CYP2C19 CYP2C9 CYP3A4 ACE TGFB1

1.39e-05501405CID000002324
Drug6-hydroxymelatonin

CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.39e-05501405CID000001864
Drugtrans-permethrin

ZAN CYP3A4 CYP3A5 PUF60 KDR TRAPPC9

1.52e-05861406CID000040159
Drugmethylpropylnitrosamine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.57e-05251404CID000013545
DrugAconitine

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.57e-05251404ctd:D000157
DrugAC1L44DC

CYP2C19 CYP2C9 CYP3A4 CYP3A5

1.57e-05251404CID000150456
Diseasegraft-versus-host disease (biomarker_via_orthology)

HSPA1A HSPA1B HSPA8

8.89e-0751333DOID:0081267 (biomarker_via_orthology)
DiseaseNodular glomerulosclerosis

ACE TGFB1 CNDP2 KDR CNDP1

1.13e-06411335C0017667
Diseasemetabolonic lactone sulfate measurement

CYP2C9 CYP3A4 CYP3A5 CYP3A43

1.45e-06191334EFO_0800659
DiseaseDiabetic Nephropathy

ACE TGFB1 CNDP2 KDR CNDP1

1.63e-06441335C0011881
DiseaseH/O: depression

ACE TGFB1

2.02e-0521332C0455503
DiseaseProton pump inhibitor response

CYP2C19 CYP3A4

2.02e-0521332cv:CN297082
DiseaseEsomeprazole response

CYP2C19 CYP3A4

2.02e-0521332cv:CN077982
Diseaseliver cirrhosis (is_marker_for)

GPT IRF5 ACE TGFB1 KDR

3.56e-05821335DOID:5082 (is_marker_for)
DiseaseX-21258 measurement

CYP2C19 CYP2C9

6.03e-0531332EFO_0800802
Diseasemean arterial pressure

CYP2C19 TBX4 PCNX3 SZT2 ZNF831 TFE3 AGXT ZFHX3 RNF32-DT ABCC10

9.24e-0549913310EFO_0006340
Diseasecoronary artery disease

COL6A3 PCNX3 DOK3 MAGI3 ZNF831 GGCX TGFB1 IGF2R AGXT SP6 KCNK5 BSN ABCC10 MRTFA RAI1 TBCD

9.81e-05119413316EFO_0001645
Diseaselymphocyte count

CYP2C19 CYP2C9 GBF1 ZAN FRAT1 CYP3A4 CYP3A5 IRF5 ZNF831 ZNF469 TLE4 SP6 ZC3H7B HSPA1A HSPA1B MRTFA RAI1 IL27RA

1.05e-04146413318EFO_0004587
Diseasetacrolimus measurement

CYP3A4 CYP3A5

1.20e-0441332EFO_0008458
DiseaseClozapine response

CYP2C19 CYP3A4

1.20e-0441332cv:CN077971
DiseaseMajor Depressive Disorder

CYP2C19 CYP2C9 CC2D1A ACE KDR HSPA1A HSPA1B

1.22e-042431337C1269683
DiseaseCarcinoma, Pancreatic Ductal

HSPA1A HSPA1B NOTCH3

1.69e-04241333C0887833
Diseasepulse pressure measurement

COL6A3 CYP2C9 IRF5 SRCAP ZNF831 TGFB1 TGFBR3 KIAA1549L MTF1 ARHGAP12 ZFHX3 SPINDOC HCFC1 MAP4K2 TRAPPC9 ABCC10 NOTCH3

1.79e-04139213317EFO_0005763
DiseaseCerebrovascular accident

ACE TGFB1 ZFHX3 NOTCH3

1.80e-04621334C0038454
DiseaseUnipolar Depression

CYP2C19 CYP2C9 CC2D1A ACE KDR HSPA1A HSPA1B

1.80e-042591337C0041696
Diseaseeosinophilic esophagitis (is_implicated_in)

CYP2C19 TGFB1

2.00e-0451332DOID:13922 (is_implicated_in)
Diseasebreast carcinoma (is_marker_for)

CA9 IGF2R KDR ZFHX3

2.29e-04661334DOID:3459 (is_marker_for)
Diseasepneumonia (is_marker_for)

IRF5 ACE TGFB1

2.70e-04281333DOID:552 (is_marker_for)
Diseaserenal cell carcinoma (is_implicated_in)

CA9 TFE3 TGFB1 SLC49A4

2.72e-04691334DOID:4450 (is_implicated_in)
Diseasehair colour measurement

ZNF831 DENND1A MSX2 ZNF469 TLE4 SLC49A4 SP6 SLA2 RNF32-DT TBCD

4.90e-0461513310EFO_0007822
DiseaseDrug Allergy

CYP2C9 ACE HSPA1A

5.27e-04351333C0013182
Diseasebeta-Ala-His dipeptidase measurement

CNDP2 CNDP1

5.55e-0481332EFO_0008033
DiseaseKidney Diseases

CYP3A5 ACE WNK1 TGFB1

6.86e-04881334C0022658
Diseaseangiotensin-converting enzyme measurement

ACE KIRREL3

7.11e-0491332EFO_0006515
Diseasemitral valve prolapse (is_implicated_in)

ACE DCHS1

7.11e-0491332DOID:988 (is_implicated_in)
Diseasefamilial Mediterranean fever (is_implicated_in)

CYP3A4 ACE

7.11e-0491332DOID:2987 (is_implicated_in)
DiseaseMajor depression, single episode

HSPA1A HSPA1B

7.11e-0491332C0024517
DiseaseEndomyocardial Fibrosis

TGFB1 IGF2R

7.11e-0491332C0553980
DiseaseReperfusion Injury

GPT KDR HSPA1A HSPA8

7.16e-04891334C0035126
Disease4-androsten-3alpha,17alpha-diol monosulfate (3) measurement

CYP2C9 CYP3A4

8.86e-04101332EFO_0022090
Diseaseobstructive jaundice (biomarker_via_orthology)

GPT IRF5

8.86e-04101332DOID:13603 (biomarker_via_orthology)
DiseaseIntellectual Disability

ZNF142 PUF60 PRR12 AP1B1 MTF1 RAI1 TBCD CNDP1

9.82e-044471338C3714756
DiseaseBerylliosis

ACE TGFB1

1.08e-03111332C0005138
DiseaseX-11308 measurement

CYP2C19 CYP2C9

1.08e-03111332EFO_0800693
DiseaseBeryllium Disease

ACE TGFB1

1.08e-03111332C2350873
DiseaseAcute kidney injury

CYP2C19 CYP2C9 TGFB1 HSPA1A

1.15e-031011334C2609414
DiseaseAcute Kidney Insufficiency

CYP2C19 CYP2C9 TGFB1 HSPA1A

1.15e-031011334C1565662
DiseaseKidney Failure, Acute

CYP2C19 CYP2C9 TGFB1 HSPA1A

1.15e-031011334C0022660
Diseasepulmonary fibrosis (implicated_via_orthology)

ACE TGFB1

1.29e-03121332DOID:3770 (implicated_via_orthology)
Diseasemetabolite measurement, body weight gain

TACC2 ZFHX3

1.29e-03121332EFO_0004566, EFO_0004725
Diseasethymol sulfate measurement

CYP2C19 CYP2C9

1.29e-03121332EFO_0021170
Diseasemethionine sulfone measurement

CYP3A4 CYP3A43

1.29e-03121332EFO_0800072
DiseaseKidney Failure, Chronic

CYP2C19 ACE TGFB1

1.34e-03481333C0022661
DiseaseColorectal Carcinoma

SHANK1 SALL3 DONSON ISLR WNK1 TGFB1 GSE1 DCHS1 KDR ACTL9

1.34e-0370213310C0009402
Diseasehepatocellular carcinoma (is_implicated_in)

CYP2C19 ACE IGF2R KDR ZFHX3

1.40e-031811335DOID:684 (is_implicated_in)
Diseasetoxic shock syndrome (is_implicated_in)

ACE HSPA1B

1.52e-03131332DOID:14115 (is_implicated_in)
Diseasecolon carcinoma (is_marker_for)

TGFB1 IGF2R

1.52e-03131332DOID:1520 (is_marker_for)
DiseaseSkin Abnormalities

ZNF469 AP1B1

1.52e-03131332C0037268
Diseaseurinary nitrogen measurement

TUBGCP6 TRAPPC9

1.77e-03141332EFO_0005190
Diseasesystemic scleroderma (is_marker_for)

ACE KDR IL27RA

1.78e-03531333DOID:418 (is_marker_for)
DiseaseAcute Cerebrovascular Accidents

ACE TGFB1 ZFHX3

1.88e-03541333C0751956
DiseaseCarcinoma, Granular Cell

ACE TGFB1 KDR HSPA8

1.91e-031161334C0205644
DiseaseAdenocarcinoma, Tubular

ACE TGFB1 KDR HSPA8

1.91e-031161334C0205645
DiseaseAdenocarcinoma, Oxyphilic

ACE TGFB1 KDR HSPA8

1.91e-031161334C0205642
DiseaseCarcinoma, Cribriform

ACE TGFB1 KDR HSPA8

1.91e-031161334C0205643
DiseaseAdenocarcinoma, Basal Cell

ACE TGFB1 KDR HSPA8

1.91e-031161334C0205641
DiseaseAdenocarcinoma

ACE TGFB1 KDR HSPA8

1.91e-031161334C0001418
DiseaseProstatic Neoplasms

CYP2C19 CYP3A4 CYP3A5 CYP3A43 ACE TGFB1 IGF2R ZFHX3 HSPA1A

1.96e-036161339C0033578
DiseaseMalignant neoplasm of prostate

CYP2C19 CYP3A4 CYP3A5 CYP3A43 ACE TGFB1 IGF2R ZFHX3 HSPA1A

1.96e-036161339C0376358
DiseaseBMI-adjusted leptin measurement

SP6 ACTL9

2.04e-03151332EFO_0007793
Diseasebody weights and measures, body height

TBX4 ADAMTS10

2.04e-03151332EFO_0004324, EFO_0004339
Disease16a-hydroxy DHEA 3-sulfate measurement

CYP2C9 CYP3A4

2.04e-03151332EFO_0800301
Diseaseglycoprotein measurement

SCAF1 SCUBE2 ZFHX3 TP53BP1

2.10e-031191334EFO_0004555
Diseasehypertension (is_implicated_in)

CYP2C9 ACE WNK1 KDR

2.23e-031211334DOID:10763 (is_implicated_in)
Diseaseandro steroid monosulfate C19H28O6S (1) measurement

CYP2C9 CYP3A4

2.32e-03161332EFO_0800305
Diseasemultiple myeloma (is_implicated_in)

CYP2C19 ACE TGFB1

2.42e-03591333DOID:9538 (is_implicated_in)
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

IGF2R SP6 MAP4K2 TP53BP1 RAI1

2.47e-032061335EFO_0004612, EFO_0020947
DiseaseUremia

TGFB1 KDR

2.62e-03171332C0041948
Diseasehypertension

COL6A3 SZT2 IRF5 ZNF831 SP6 KCNK5

2.75e-033071336EFO_0000537
Diseasehair color

ZNF831 MSX2 KIRREL3 SLC49A4 SP6 TBCD

2.93e-033111336EFO_0003924
Diseaseobesity (implicated_via_orthology)

SDK2 GORASP2 DCHS1 ZFHX3 NOTCH3

2.96e-032151335DOID:9970 (implicated_via_orthology)
DiseaseGlobal developmental delay

ZNF142 SZT2 PRR12 AP1B1

3.14e-031331334C0557874
Diseaseemphysema pattern measurement

VWA8 TRAPPC9

3.28e-03191332EFO_0005850
Diseasesystemic lupus erythematosus

COL6A3 PCNX3 MAGI3 IRF5 SRCAP ZNF831 MTF1 HSPA1A HSPA1B CCDC136

3.41e-0379913310MONDO_0007915
Diseaseserum metabolite measurement

CYP2C9 CYP3A4 CYP3A5 CYP3A43 ACE IGF2R GSE1 CNDP2 ZFHX3 MAP4K2 HSPA8

3.74e-0394513311EFO_0005653
Diseasestomach cancer (is_implicated_in)

ACE GSE1 KDR

4.26e-03721333DOID:10534 (is_implicated_in)
Diseasetriacylglycerol 58:9 measurement

GBF1 TMEM132E

4.39e-03221332EFO_0010443
Diseaseimpotence (biomarker_via_orthology)

TGFB1 KDR

4.39e-03221332DOID:1875 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PGLAGEQPLQAPLLP

nan

76

Q6ZRM9
PVPGQALLDLVVSPP

GPT

351

P24298
LLPPQPALALDPGLQ

ACE

21

P12821
PPEPGLLPNGTVTLL

ADGRA2

76

Q96PE1
LGIPGPTPLPLLGNV

CYP3A5

36

P20815
LIVEPPLPQEKAGGP

GSE1

156

Q14687
LFNPPEVPGLSPVGL

ACTL9

301

Q8TC94
DLLNLDLGPPVSGPP

AP1B1

631

Q10567
LLEGLPGTPQPHRLP

ADAMTS10

756

Q9H324
LPLTQPVGPINRPVG

ADNP2

401

Q6IQ32
PLLIPAPAPGLTVQL

CA9

11

Q16790
LLVEGSFLGDPPIPP

RNF32-DT

136

Q8NI28
TLPGGSILQPRPSLP

RAI1

1651

Q7Z5J4
EALGLGPPAAQLTPP

RAVER1

451

Q8IY67
LLAQGLRPESPPPAG

NIBAN2

656

Q96TA1
PDILIPPEGIPGSAQ

MAP4K2

691

Q12851
PVLNGVLPKPPAILG

CAPN15

81

O75808
NGIESLGVKPDLPPP

HCFC1

1786

P51610
LLDLLPVALPPGAGP

ABCC10

81

Q5T3U5
GLPIQVPDRVPPGTL

DCHS1

1221

Q96JQ0
PRPLQLPGAEGPAIS

LARP1

76

Q6PKG0
PLAPGEPEGPSLLVA

MBD6

586

Q96DN6
GALPSLLQPPGPLLS

MBD6

756

Q96DN6
GALLLPLVLPGDPPA

SLC16A11

211

Q8NCK7
PGSPFPPEGLDLVIQ

KIAA0100

996

Q14667
PPLPPGGQELLELLL

GPSM3

126

Q9Y4H4
ADVPLLILRGGPPSP

MAGI3

646

Q5TCQ9
TLPGLMPLPAGLPNL

GORASP2

301

Q9H8Y8
GPLAPGPHQVPLDLV

IL17B

36

Q9UHF5
TPGLLPQDLPPSVLA

NUDT17

231

P0C025
VALKVLVPPNIEPGP

HMCN2

1886

Q8NDA2
PLGIAGQPILPDFDP

ENOX2

51

Q16206
GFQPLLNGSLVPVPP

ESPN

711

B1AK53
SPYLPGIQIVTPGPL

BSN

2741

Q9UPA5
LGIPGPTPLPFLGNI

CYP3A4

36

P08684
AEGVPGQLPPGLLLL

ISLR

401

O14498
LPPPLSGQLVTPADI

MBD3L5

161

A6NJ08
LSGIPPAPRGVPQIE

HSPA1B

461

P0DMV9
KLIGDLPQTPPGAVP

PCNX3

191

Q9H6A9
GGGLPALPPSLVPLV

KCNK5

331

O95279
GAIIPFPLAPGQSLP

MSTO1

371

Q9BUK6
LPPPLSGQLVTPADI

MBD3L2B

161

A0A1B0GVZ6
LLPLAPGPQLLNPGT

NOTCH3

2186

Q9UM47
PVLPPVAVLPLGTGN

DGKA

451

P23743
PEELGLLGPPRPQVL

IL27RA

621

Q6UWB1
GPQSLPLLLGPEPND

DOK3

361

Q7L591
PGLLTPQPLKPLAVG

TUBGCP6

861

Q96RT7
PPALGSLLQLPDGSP

KIAA1549L

61

Q6ZVL6
PTLPSPPAEAGLGLE

LMNTD2

566

Q8IXW0
PLVVLGLPAPTAPSG

NAGS

171

Q8N159
GPLPASLPPAGEQLL

IRF5

221

Q13568
GLQVLTHPEPPLPQG

INSM2

386

Q96T92
DSPLLGPPVGEPRLL

GTSE1

151

Q9NYZ3
LPPPLSGQLVTPADI

MBD3L3

161

A6NE82
PLQGPGLLSVPNLPE

NUP155

66

O75694
LPPLPGSPAIQINGE

ARHGAP12

256

Q8IWW6
TPAPGLLKVPVPGLG

PRR35

296

P0CG20
LPPPRLGENGLPISE

PATZ1

326

Q9HBE1
LLLPGPPPVAGLEDA

PODNL1

16

Q6PEZ8
PGPTPLPVIGNILQI

CYP2C19

31

P33261
LGIPGPTPLPFLGTI

CYP3A43

36

Q9HB55
EGLRGLVTTAPLPPP

COL20A1

456

Q9P218
GPLVVPAPNGTSPLL

SLC49A4

201

Q96SL1
PASLPPGDPQLIALI

BOD1

41

Q96IK1
LQPVLQPLPSPGVGG

COL6A3

1216

P12111
NLPTPPGLSPGDLDV

CC2D1A

666

Q6P1N0
GLLPGVVPQGPTELL

DENND1A

751

Q8TEH3
PTELLQPLSPGPGAA

DENND1A

761

Q8TEH3
GPQAGLPPTLLSPVA

DONSON

426

Q9NYP3
VPLLLPPALAETVGP

FRAT1

91

Q92837
GLHIPPNLSLPVPGA

INHA

296

P05111
PPLILQPLASPLQVG

GBF1

1806

Q92538
PPDDPVILGGPVISL

KIRREL3

146

Q8IZU9
LSGIPPAPRGVPQIE

HSPA1A

461

P0DMV8
PGPTPLPVIGNILQI

CYP2C9

31

P11712
IPLIPPQAQELGIPL

FAM186A

1481

A6NE01
LIPPQAQELGIPLTP

FAM186A

1531

A6NE01
LLPPLLLLAGAVPPG

SCUBE2

21

Q9NQ36
VGGPADPIAPTIIIP

SDK2

206

Q58EX2
LLGAAPGLPSPLLPQ

SALL3

351

Q9BXA9
LPPQTLEGLQPTGPE

INAVA

296

Q3KP66
LIDPSSGLPNRLPPG

PSMF1

221

Q92530
LPPPLSGQLVTPADI

MBD3L4

161

A6NDZ8
LSSGQLPPLLIPTDP

PRDM2

956

Q13029
LSPFVPGPGPLQTDL

POM121L1P

81

Q3SYA9
LTGIPPAPRGVPQIE

HSPA8

461

P11142
LLGVPGGPRPQLQLP

INAFM1

96

C9JVW0
LPPPLSGQLVTPADI

MBD3L2

161

Q8NHZ7
VLPIPPVGLYATPVG

MSX2

246

P35548
GELPELLPPIHPGLL

FAM83G

386

A6ND36
PLLVTAGAPPGGPLV

NUTM2D

91

Q5VT03
LLQVPPSGLQGLPPV

FER1L6

956

Q2WGJ9
PIDIGRVAGPPILNP

IGF2R

1721

P11717
LTLEPPGPLPLVSGR

SZT2

766

Q5T011
PLPTVPGGLSPVQRE

TCP11L1

461

Q9NUJ3
KPLSIPNQLLLGPGP

AGXT

16

P21549
NPILASPPTLGLLEP

PUF60

401

Q9UHX1
AGPLPGKDIPLPVTV

SLA2

196

Q9H6Q3
STPLPPREGQGPLEI

TMEM132E

376

Q6IEE7
LVLQPGLSEPPQPLL

MTF1

421

Q14872
PPGGPVPLSVLILSL

SLITRK3

646

O94933
PPPLTLAQKLGLIGP

RNF32

86

Q9H0A6
PEPPLGLLDGLIPLA

SHROOM1

566

Q2M3G4
PAPPPGLRGTLDLQV

SPINDOC

311

Q9BUA3
PLQPGELQSLPLGPE

SP6

46

Q3SY56
QELLGALEPLPPAPG

PRR12

881

Q9ULL5
PGGLELTPPVVSLTP

SRCAP

3101

Q6ZRS2
LELTLGVTPEGNPPP

RIC8A

196

Q9NPQ8
PAPQLLLGPQGPSLI

MRTFA

636

Q969V6
PEPLPTPHVLLQGLG

SLC39A5

501

Q6ZMH5
GPLLLQLGTEPPAPH

SHANK1

1456

Q9Y566
PNPPIFSLPLVGLVV

CCDC136

1126

Q96JN2
QLPDGQSLPIPPVIL

CNDP1

101

Q96KN2
PLPPILLGRLGSDPQ

CNDP2

76

Q96KP4
TGPLPPELQPLLEGE

GGCX

631

P38435
IHGLPVPPTPGLLSL

TFE3

436

P19532
PGGGLLPTPNPLTQI

SRSF11

136

Q05519
QPPAIPPIGSSAGLL

TLE4

156

Q04727
VVTAGGAALPPPLLP

SCAF1

371

Q9H7N4
PLPNLPVGPGDTISI

STYXL2

706

Q5VZP5
GEVPPGPLPEAVLAL

TGFB1

66

P01137
VELEALLPPPGAVPG

PPP1R3F

136

Q6ZSY5
QPEGGLPVSPEPSLL

TACC2

396

O95359
EGDIIPPLTGATPPL

TP53BP1

911

Q12888
LELAYVLVLGPGPPP

ZDHHC24

31

Q6UX98
PGSPGPLLQQALPLG

ZNF469

3556

Q96JG9
PLSLQPLVPSGLPAV

ZNF843

226

Q8N446
PGPGPLNVGLHLNPL

TSPYL6

191

Q8N831
VPPVSGPLALPALGK

ZNF687

621

Q8N1G0
DLLGVPRPQLVPQPG

TBCD

1176

Q9BTW9
IALPGGLTLPPVPFT

TRAPPC9

521

Q96Q05
LGPQPLPIHVGELPT

KDR

586

P35968
IAGVSGVDDLPPPPL

TBX4

401

P57082
LIPPPLSNRGILGPV

ZNF142

26

P52746
TALELPGLPLSLPQP

WNK1

91

Q9H4A3
LPPTNLPLGTVALPV

WNK1

1711

Q9H4A3
TLGPVLLPPEQGLAP

ZNF831

36

Q5JPB2
LDPFGTGQPLPPLQI

SEC31A

356

O94979
LLGQDVFLIGPPGPL

VWA8

101

A3KMH1
EITNGPLISLLPKPP

VWA3A

376

A6NCI4
ILLDPGALPALQNPP

TGFBR3

376

Q03167
PALQGIPPVLLPGLN

ZFHX3

3116

Q15911
SELPQLIPVFPGGTP

ZC3H7B

286

Q9UGR2
ELLLGSPAGSPPIPL

ZAN

466

Q9Y493
EVGPLLGVQPLPGSP

ZBTB3

536

Q9H5J0
LPLQDTGPTSGPEPL

NACAD

926

O15069
NIAGDSLGLALPPPP

NEDD4L

281

Q96PU5