Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RS domain binding	LUC7L SRSF10 SRSF12	1.10e-06	8	55	3	GO:0050733
GeneOntologyMolecularFunction	pre-mRNA 3'-splice site binding	ZRSR2P1 ZRSR2	1.55e-04	7	55	2	GO:0030628
GeneOntologyMolecularFunction	nodal binding	LEFTY2 LEFTY1	2.06e-04	8	55	2	GO:0038100
GeneOntologyBiologicalProcess	mRNA processing	SNIP1 LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CPSF6 CDK13 PRPF38B SRRM2 SRSF12 RBM17	9.70e-10	551	53	13	GO:0006397
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	SNIP1 LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CDK13 SRRM2 SRSF12 RBM17	1.47e-09	358	53	11	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	SNIP1 LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CDK13 SRRM2 SRSF12 RBM17	1.47e-09	358	53	11	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	SNIP1 LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CDK13 SRRM2 SRSF12 RBM17	1.65e-09	362	53	11	GO:0000375
GeneOntologyBiologicalProcess	RNA splicing	SNIP1 LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CDK13 PRPF38B SRRM2 SRSF12 RBM17	4.08e-09	502	53	12	GO:0008380
GeneOntologyBiologicalProcess	mRNA metabolic process	SNIP1 LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CPSF6 CDK13 PRPF38B TNKS1BP1 SRRM2 SRSF12 RBM17	5.08e-08	917	53	14	GO:0016071
GeneOntologyBiologicalProcess	spliceosomal complex assembly	SNIP1 LUC7L SRSF10 DDX46 ZRSR2 SRSF12	2.01e-07	99	53	6	GO:0000245
GeneOntologyBiologicalProcess	negative regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	6.48e-06	2	53	2	GO:1900124
GeneOntologyBiologicalProcess	regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	6.48e-06	2	53	2	GO:1900123
GeneOntologyBiologicalProcess	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	VANGL2 CELSR1	6.48e-06	2	53	2	GO:0060488
GeneOntologyBiologicalProcess	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	VANGL2 CELSR1	6.48e-06	2	53	2	GO:0060489
GeneOntologyBiologicalProcess	lateral sprouting involved in lung morphogenesis	VANGL2 CELSR1	6.48e-06	2	53	2	GO:0060490
GeneOntologyBiologicalProcess	nodal receptor complex assembly	LEFTY2 LEFTY1	6.48e-06	2	53	2	GO:0038099
GeneOntologyBiologicalProcess	dichotomous subdivision of terminal units involved in lung branching	VANGL2 CELSR1	1.94e-05	3	53	2	GO:0060448
GeneOntologyBiologicalProcess	protein-RNA complex assembly	SNIP1 LUC7L SRSF10 DDX46 ZRSR2 SRSF12	3.72e-05	244	53	6	GO:0022618
GeneOntologyBiologicalProcess	establishment of body hair planar orientation	VANGL2 CELSR1	3.87e-05	4	53	2	GO:0048105
GeneOntologyBiologicalProcess	establishment of body hair or bristle planar orientation	VANGL2 CELSR1	3.87e-05	4	53	2	GO:0048104
GeneOntologyBiologicalProcess	protein-RNA complex organization	SNIP1 LUC7L SRSF10 DDX46 ZRSR2 SRSF12	4.65e-05	254	53	6	GO:0071826
GeneOntologyBiologicalProcess	RNA processing	SNIP1 LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CPSF6 CDK13 PRPF38B SRRM2 SRSF12 RBM17	8.13e-05	1500	53	13	GO:0006396
GeneOntologyBiologicalProcess	negative regulation of nodal signaling pathway	LEFTY2 LEFTY1	1.35e-04	7	53	2	GO:1900108
GeneOntologyBiologicalProcess	regulation of nodal signaling pathway	LEFTY2 LEFTY1	2.31e-04	9	53	2	GO:1900107
GeneOntologyBiologicalProcess	mRNA splice site recognition	LUC7L SRSF10 SRSF12	3.24e-04	52	53	3	GO:0006376
GeneOntologyBiologicalProcess	dichotomous subdivision of an epithelial terminal unit	VANGL2 CELSR1	3.51e-04	11	53	2	GO:0060600
GeneOntologyBiologicalProcess	lateral sprouting from an epithelium	VANGL2 CELSR1	4.96e-04	13	53	2	GO:0060601
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity involved in neural tube closure	VANGL2 CELSR1	6.66e-04	15	53	2	GO:0090178
GeneOntologyBiologicalProcess	regulation of JUN kinase activity	VANGL2 MAP3K12 PDCD4	6.83e-04	67	53	3	GO:0043506
GeneOntologyBiologicalProcess	establishment of planar polarity involved in neural tube closure	VANGL2 CELSR1	7.60e-04	16	53	2	GO:0090177
GeneOntologyBiologicalProcess	apical protein localization	VANGL2 CELSR1	8.60e-04	17	53	2	GO:0045176
GeneOntologyBiologicalProcess	establishment of planar polarity of embryonic epithelium	VANGL2 CELSR1	9.65e-04	18	53	2	GO:0042249
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity	VANGL2 CELSR1	1.08e-03	19	53	2	GO:0090175
GeneOntologyBiologicalProcess	alternative mRNA splicing, via spliceosome	CDK13 SRSF12 RBM17	1.10e-03	79	53	3	GO:0000380
GeneOntologyBiologicalProcess	cell migration involved in gastrulation	LEFTY2 LEFTY1	1.19e-03	20	53	2	GO:0042074
GeneOntologyBiologicalProcess	negative regulation of activin receptor signaling pathway	LEFTY2 LEFTY1	1.32e-03	21	53	2	GO:0032926
GeneOntologyCellularComponent	spliceosomal complex	SNIP1 LUC7L ZRSR2P1 DDX46 PNN ZRSR2 PRPF38B SRRM2 RBM17	4.60e-09	215	55	9	GO:0005681
GeneOntologyCellularComponent	nuclear speck	SRSF10 DDX46 PNN RBBP6 CPSF6 CDK13 SRRM2 SRSF12	1.59e-05	431	55	8	GO:0016607
GeneOntologyCellularComponent	U2-type spliceosomal complex	SNIP1 LUC7L DDX46 SRRM2	1.24e-04	97	55	4	GO:0005684
GeneOntologyCellularComponent	U2AF complex	ZRSR2P1 ZRSR2	1.42e-04	7	55	2	GO:0089701
GeneOntologyCellularComponent	nuclear protein-containing complex	SNIP1 LUC7L ZRSR2P1 DDX46 PNN ZRSR2 CPSF6 CDK13 PRPF38B TIMELESS SRRM2 RBM17	1.97e-04	1377	55	12	GO:0140513
GeneOntologyCellularComponent	precatalytic spliceosome	SNIP1 PRPF38B SRRM2	3.89e-04	54	55	3	GO:0071011
GeneOntologyCellularComponent	ribonucleoprotein complex	SNIP1 LUC7L ZRSR2P1 DDX46 PNN ZRSR2 CPSF6 PRPF38B SRRM2 RBM17	9.90e-04	1194	55	10	GO:1990904
GeneOntologyCellularComponent	spliceosomal snRNP complex	SNIP1 LUC7L DDX46	2.07e-03	96	55	3	GO:0097525
GeneOntologyCellularComponent	nuclear body	SRSF10 DDX46 PNN RBBP6 CPSF6 CDK13 SRRM2 SRSF12	2.36e-03	903	55	8	GO:0016604
GeneOntologyCellularComponent	U2 snRNP	SNIP1 DDX46	2.46e-03	28	55	2	GO:0005686
GeneOntologyCellularComponent	small nuclear ribonucleoprotein complex	SNIP1 LUC7L DDX46	2.82e-03	107	55	3	GO:0030532
GeneOntologyCellularComponent	U12-type spliceosomal complex	ZRSR2P1 ZRSR2	2.82e-03	30	55	2	GO:0005689
MousePheno	abnormal left renal vein morphology	LEFTY2 LEFTY1	8.39e-06	2	41	2	MP:0011327
MousePheno	abnormal renal vein morphology	LEFTY2 LEFTY1	8.39e-06	2	41	2	MP:0011323
MousePheno	abnormal kidney venous blood vessel morphology	LEFTY2 LEFTY1	2.51e-05	3	41	2	MP:0011311
MousePheno	dilated terminal bronchiole tube	VANGL2 CELSR1	5.02e-05	4	41	2	MP:0006026
MousePheno	abnormal large intestine placement	LEFTY2 LEFTY1	5.02e-05	4	41	2	MP:0003284
MousePheno	complete atrioventricular septal defect	LEFTY2 LEFTY1 SRSF10	5.81e-05	26	41	3	MP:0010413
MousePheno	abnormal respiratory conducting tube morphology	VANGL2 LEFTY2 LEFTY1 CELSR1	8.16e-05	79	41	4	MP:0004391
MousePheno	impaired branching involved in terminal bronchiole morphogenesis	VANGL2 CELSR1	8.35e-05	5	41	2	MP:0011032
MousePheno	absent heart right ventricle	LEFTY2 LEFTY1	1.25e-04	6	41	2	MP:0003872
MousePheno	small lung lobe	VANGL2 CELSR1	1.75e-04	7	41	2	MP:0010976
MousePheno	abnormal branching involved in terminal bronchiole morphogenesis	VANGL2 CELSR1	1.75e-04	7	41	2	MP:0011031
MousePheno	left atrial isomerism	LEFTY2 LEFTY1	2.32e-04	8	41	2	MP:0008461
MousePheno	accessory spleen	LEFTY2 LEFTY1	2.98e-04	9	41	2	MP:0003342
MousePheno	tricuspid valve atresia	LEFTY2 LEFTY1	2.98e-04	9	41	2	MP:0006123
MousePheno	transposition of great arteries	LEFTY2 LEFTY1 PNN	3.47e-04	47	41	3	MP:0004110
MousePheno	abnormal terminal bronchiole morphology	VANGL2 CELSR1	3.72e-04	10	41	2	MP:0002268
MousePheno	abnormal cardiac outflow tract development	VANGL2 LEFTY2 LEFTY1 PNN	6.21e-04	134	41	4	MP:0006126
MousePheno	right aortic arch	VANGL2 LEFTY2 LEFTY1	7.14e-04	60	41	3	MP:0004158
MousePheno	absent heart	LEFTY2 LEFTY1	7.47e-04	14	41	2	MP:0011388
MousePheno	abnormal notochord morphology	VANGL2 LEFTY2 LEFTY1	8.23e-04	63	41	3	MP:0002825
MousePheno	ventricular septal defect	VANGL2 LEFTY2 LEFTY1 SRSF10 PNN	9.45e-04	261	41	5	MP:0010402
MousePheno	double outlet right ventricle	VANGL2 LEFTY2 LEFTY1 PNN	9.47e-04	150	41	4	MP:0000284
MousePheno	abnormal hepatic portal vein morphology	LEFTY2 LEFTY1	9.81e-04	16	41	2	MP:0010668
MousePheno	abnormal heart atrium arrangement	LEFTY2 LEFTY1	1.11e-03	17	41	2	MP:0014319
MousePheno	craniorachischisis	VANGL2 CELSR1	1.11e-03	17	41	2	MP:0008784
MousePheno	abnormal intestine placement	LEFTY2 LEFTY1	1.25e-03	18	41	2	MP:0014023
MousePheno	absent notochord	LEFTY2 LEFTY1	1.39e-03	19	41	2	MP:0000932
Domain	LRDF	LEFTY2 LEFTY1	8.51e-06	2	55	2	IPR003942
Domain	Nucleotide-bd_a/b_plait	ZRSR2P1 SRSF10 DDX50 ZRSR2 CPSF6 SRSF12 RBM17	1.02e-05	258	55	7	IPR012677
Domain	K_chnl_volt-dep_ELK	KCNH8 KCNH3	2.55e-05	3	55	2	IPR003950
Domain	RRM_1	ZRSR2P1 SRSF10 ZRSR2 CPSF6 SRSF12 RBM17	3.27e-05	208	55	6	PF00076
Domain	RRM_dom	ZRSR2P1 SRSF10 ZRSR2 CPSF6 SRSF12 RBM17	5.32e-05	227	55	6	IPR000504
Domain	RRM	ZRSR2P1 SRSF10 ZRSR2 CPSF6 SRSF12 RBM17	5.72e-05	230	55	6	PS50102
Domain	U2AF_small	ZRSR2P1 ZRSR2	8.47e-05	5	55	2	IPR009145
Domain	PAS_9	KCNH8 KCNH3	3.77e-04	10	55	2	PF13426
Domain	RRM	ZRSR2P1 SRSF10 ZRSR2 CPSF6 SRSF12	4.39e-04	217	55	5	SM00360
Domain	-	SRSF10 ZRSR2 CPSF6 SRSF12 RBM17	7.46e-04	244	55	5	3.30.70.330
Domain	K_chnl_volt-dep_EAG/ELK/ERG	KCNH8 KCNH3	7.57e-04	14	55	2	IPR003938
Domain	PAS_fold_3	KCNH8 KCNH3	2.07e-03	23	55	2	IPR013655
Domain	RRM_dom_euk	ZRSR2 RBM17	2.07e-03	23	55	2	IPR003954
Domain	PAS_3	KCNH8 KCNH3	2.07e-03	23	55	2	PF08447
Domain	RRM_1	ZRSR2 RBM17	2.07e-03	23	55	2	SM00361
Domain	PAS-assoc_C	KCNH8 KCNH3	2.25e-03	24	55	2	IPR000700
Domain	PAC	KCNH8 KCNH3	2.64e-03	26	55	2	SM00086
Domain	PAC	KCNH8 KCNH3	2.64e-03	26	55	2	PS50113
Domain	PAC	KCNH8 KCNH3	2.64e-03	26	55	2	IPR001610
Domain	TGFb_propeptide	LEFTY2 LEFTY1	3.06e-03	28	55	2	PF00688
Domain	TGF-b_N	LEFTY2 LEFTY1	3.06e-03	28	55	2	IPR001111
Domain	TGF-beta-rel	LEFTY2 LEFTY1	3.99e-03	32	55	2	IPR015615
Domain	CNMP_BINDING_1	KCNH8 KCNH3	3.99e-03	32	55	2	PS00888
Domain	CNMP_BINDING_2	KCNH8 KCNH3	3.99e-03	32	55	2	PS00889
Domain	TGFb_CS	LEFTY2 LEFTY1	3.99e-03	32	55	2	IPR017948
Domain	cNMP	KCNH8 KCNH3	4.50e-03	34	55	2	SM00100
Domain	PAS	KCNH8 KCNH3	4.50e-03	34	55	2	IPR000014
Domain	PAS	KCNH8 KCNH3	4.50e-03	34	55	2	PS50112
Domain	cNMP_binding	KCNH8 KCNH3	4.50e-03	34	55	2	PF00027
Domain	cNMP-bd_dom	KCNH8 KCNH3	4.76e-03	35	55	2	IPR000595
Domain	CNMP_BINDING_3	KCNH8 KCNH3	4.76e-03	35	55	2	PS50042
Domain	TGFB	LEFTY2 LEFTY1	5.31e-03	37	55	2	SM00204
Domain	TGF_BETA_2	LEFTY2 LEFTY1	5.31e-03	37	55	2	PS51362
Domain	TGF_beta	LEFTY2 LEFTY1	5.31e-03	37	55	2	PF00019
Domain	RNA_helicase_DEAD_Q_motif	DDX46 DDX50	5.31e-03	37	55	2	IPR014014
Domain	Q_MOTIF	DDX46 DDX50	5.31e-03	37	55	2	PS51195
Domain	TGF-b_C	LEFTY2 LEFTY1	5.31e-03	37	55	2	IPR001839
Domain	TGF_BETA_1	LEFTY2 LEFTY1	5.31e-03	37	55	2	PS00250
Domain	cNMP-bd-like	KCNH8 KCNH3	5.59e-03	38	55	2	IPR018490
Domain	ZnF_C3H1	ZRSR2P1 ZRSR2	8.81e-03	48	55	2	SM00356
Domain	-	KCNH8 KCNH3	8.81e-03	48	55	2	2.60.120.10
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	SNIP1 ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CPSF6 SRRM2 RBM17	6.15e-08	277	40	9	MM15414
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	SNIP1 SRSF10 DDX46 PNN ZRSR2 CPSF6 SRRM2 SRSF12 RBM17	7.39e-08	283	40	9	M13087
Pathway	REACTOME_MRNA_SPLICING	SNIP1 ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 SRRM2 RBM17	7.73e-08	201	40	8	MM15411
Pathway	REACTOME_MRNA_SPLICING	SNIP1 SRSF10 DDX46 PNN ZRSR2 SRRM2 SRSF12 RBM17	1.17e-07	212	40	8	M14033
Pathway	REACTOME_METABOLISM_OF_RNA	SNIP1 ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CPSF6 TNKS1BP1 SRRM2 RBM17	5.75e-06	612	40	10	MM15547
Pathway	REACTOME_METABOLISM_OF_RNA	SNIP1 SRSF10 DDX46 PNN ZRSR2 CPSF6 TNKS1BP1 SRRM2 SRSF12 RBM17	2.50e-05	724	40	10	M16843
Pathway	KEGG_SPLICEOSOME	SRSF10 DDX46 PRPF38B RBM17	4.47e-04	127	40	4	M2044
Pathway	WP_MIR127_IN_MESENDODERM_DIFFERENTIATION	LEFTY2 LEFTY1	5.09e-04	12	40	2	MM15910
Pathway	REACTOME_REGULATION_OF_SIGNALING_BY_NODAL	LEFTY2 LEFTY1	5.09e-04	12	40	2	M26952
Pathway	WP_MRNA_PROCESSING	ZRSR2P1 SRSF10 ZRSR2 RSRC2 SRSF12 RBM17	1.58e-03	451	40	6	MM15946
Pathway	REACTOME_SIGNALING_BY_NODAL	LEFTY2 LEFTY1	1.91e-03	23	40	2	M511
Pubmed	The protein interaction landscape of the human CMGC kinase group.	LUC7L SRSF10 DDX46 DDX50 PNN ZRSR2 RBBP6 CPSF6 CDK13 SIPA1L3 TNKS1BP1 RSRC2 SRRM2 SRSF12	2.91e-12	695	55	14	23602568
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	VANGL2 LUC7L SRSF10 DDX46 DDX50 PNN ZRSR2 RBBP6 CPSF6 PRPF38B TNKS1BP1 RSRC2 SRRM2 GNS RBM17	8.35e-11	1082	55	15	38697112
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	LENG8 SNIP1 LUC7L SRSF10 DDX46 DDX50 PNN RBBP6 PRPF38B RSRC2 SRRM2 SRSF12 RBM17	9.06e-11	731	55	13	29298432
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	LENG8 SNIP1 LUC7L ZRSR2P1 RBBP6 CPSF6 PRPF38B SRSF12 RBM17	2.19e-10	251	55	9	31076518
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SNIP1 LUC7L DDX46 DDX50 PNN RBBP6 CDK13 SIPA1L3 PRPF38B SRRM2	2.48e-10	361	55	10	26167880
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SNIP1 LUC7L SRSF10 DDX50 PNN RBBP6 CPSF6 PRPF38B RSRC2 SRRM2 SRSF12 RBM17	9.86e-10	713	55	12	29802200
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SRSF10 PNN CPSF6 TNKS1BP1 SRRM2 PDCD4 RBM17	7.33e-09	163	55	7	22113938
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	LUC7L SRSF10 DDX50 PNN ZRSR2 RBBP6 CPSF6 CDK13 PRPF38B SRSF12 RBM17	1.51e-08	723	55	11	34133714
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	LENG8 SNIP1 LUC7L SRSF10 DDX46 VTN CPSF6 CDK13 SIPA1L3 PRPF38B EIF2AK4 RSRC2 RBM17	1.63e-07	1371	55	13	36244648
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	SNIP1 LUC7L DDX46 DDX50 PNN RBBP6 CPSF6 CDK13 SRRM2 PDCD4 RBM17	2.35e-07	949	55	11	36574265
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	LENG8 SNIP1 CELSR1 SRSF10 DDX46 GPBP1L1 DDX50 RBBP6 CPSF6 CDK13 SIPA1L3 PRPF38B RSRC2	4.43e-07	1497	55	13	31527615
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	LUC7L SRSF10 PNN RBBP6 CPSF6 SIPA1L3 PRPF38B TNKS1BP1 RSRC2 SRRM2 PDCD4 RBM17	4.51e-07	1247	55	12	27684187
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 CDK13 RSRC2 SRRM2 SRSF12	4.87e-07	807	55	10	22681889
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	SNIP1 LUC7L SRSF10 DDX46 SRRM2 RBM17	7.04e-07	197	55	6	22365833
Pubmed	Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.	VANGL2 LEFTY2 LEFTY1	8.15e-07	12	55	3	19706528
Pubmed	Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.	LUC7L DDX46 RBBP6 CPSF6 PRPF38B SRRM2	9.14e-07	206	55	6	34185411
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	LENG8 DDX46 RBBP6 CPSF6 TNKS1BP1 SRRM2 RBM17	1.11e-06	341	55	7	32971831
Pubmed	Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm.	LEFTY2 LEFTY1 DMBX1	1.68e-06	15	55	3	19615442
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	LENG8 DDX46 DDX50 PNN RBBP6 CPSF6 PRPF38B TNKS1BP1 PDCD4 RBM17	1.82e-06	934	55	10	33916271
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	LENG8 SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 SRRM2 SRSF12 RBM17	2.20e-06	954	55	10	36373674
Pubmed	Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.	LEFTY2 LEFTY1	2.46e-06	2	55	2	20171171
Pubmed	Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.	LEFTY2 LEFTY1	2.46e-06	2	55	2	9496783
Pubmed	A functional role of LEFTY during progesterone therapy for endometrial carcinoma.	LEFTY2 LEFTY1	2.46e-06	2	55	2	29268772
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2P1 ZRSR2	2.46e-06	2	55	2	35198906
Pubmed	Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.	LEFTY2 LEFTY1	2.46e-06	2	55	2	29286065
Pubmed	LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.	LEFTY2 LEFTY1	2.46e-06	2	55	2	32745796
Pubmed	Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.	LEFTY2 LEFTY1	2.46e-06	2	55	2	24147624
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2P1 ZRSR2	2.46e-06	2	55	2	33691379
Pubmed	Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons.	KCNH8 KCNH3	2.46e-06	2	55	2	37516908
Pubmed	Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.	LEFTY2 LEFTY1	2.46e-06	2	55	2	21401636
Pubmed	Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct.	VANGL2 CELSR1	2.46e-06	2	55	2	25406397
Pubmed	Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.	LEFTY2 LEFTY1	2.46e-06	2	55	2	33409963
Pubmed	LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.	LEFTY2 LEFTY1	2.46e-06	2	55	2	29230527
Pubmed	Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing.	SRSF10 SRSF12	2.46e-06	2	55	2	11684676
Pubmed	LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.	LEFTY2 LEFTY1	2.46e-06	2	55	2	20056823
Pubmed	Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.	LEFTY2 LEFTY1	2.46e-06	2	55	2	10053005
Pubmed	Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period.	LEFTY2 LEFTY1	2.46e-06	2	55	2	15640253
Pubmed	Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.	LEFTY2 LEFTY1	2.46e-06	2	55	2	11100524
Pubmed	Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.	LEFTY2 LEFTY1	2.46e-06	2	55	2	17038673
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SRSF10 DDX46 PNN RBBP6 CDK13 PRPF38B TNKS1BP1 TIMELESS SRRM2	3.25e-06	774	55	9	15302935
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	SNIP1 DDX50 PNN CDK13 SRRM2 RBM17	3.44e-06	259	55	6	30404004
Pubmed	BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.	SRSF10 PNN SRRM2	3.56e-06	19	55	3	25263594
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SNIP1 LUC7L SRSF10 DDX46 DDX50 PNN RBBP6 CDK13 SRRM2 USP3 RBM17	4.82e-06	1294	55	11	30804502
Pubmed	Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.	VANGL2 LEFTY2 LEFTY1	4.88e-06	21	55	3	20562861
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SNIP1 LUC7L SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 PRPF38B SRRM2 PDCD4	5.73e-06	1318	55	11	30463901
Pubmed	Two modes by which Lefty proteins inhibit nodal signaling.	LEFTY2 LEFTY1	7.36e-06	3	55	2	15062104
Pubmed	Nodal and lefty signaling regulates the growth of pancreatic cells.	LEFTY2 LEFTY1	7.36e-06	3	55	2	18393305
Pubmed	Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.	LEFTY2 LEFTY1	7.36e-06	3	55	2	17011489
Pubmed	Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.	LEFTY2 LEFTY1	7.36e-06	3	55	2	32065356
Pubmed	Lefty-1 alleviates TGF-β1-induced fibroblast-myofibroblast transdifferentiation in NRK-49F cells.	LEFTY2 LEFTY1	7.36e-06	3	55	2	26316705
Pubmed	Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.	ZRSR2P1 ZRSR2	7.36e-06	3	55	2	8586425
Pubmed	Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.	LEFTY2 LEFTY1	7.36e-06	3	55	2	33111989
Pubmed	Role of asymmetric signals in left-right patterning in the mouse.	LEFTY2 LEFTY1	7.36e-06	3	55	2	11471154
Pubmed	Lefty1 alleviates renal tubulointerstitial injury in mice with unilateral ureteral obstruction.	LEFTY2 LEFTY1	7.36e-06	3	55	2	26647776
Pubmed	TGFβ signaling in establishing left-right asymmetry.	LEFTY2 LEFTY1	7.36e-06	3	55	2	24704359
Pubmed	Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.	LEFTY2 LEFTY1	7.36e-06	3	55	2	16141390
Pubmed	Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.	ZRSR2P1 ZRSR2	7.36e-06	3	55	2	36030305
Pubmed	IFT46 plays an essential role in cilia development.	LEFTY2 LEFTY1	7.36e-06	3	55	2	25722189
Pubmed	Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.	LEFTY2 LEFTY1	7.36e-06	3	55	2	9865700
Pubmed	Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.	LEFTY2 LEFTY1	7.36e-06	3	55	2	10886363
Pubmed	Nodal activates smad and extracellular signal-regulated kinases 1/2 pathways promoting renal cell carcinoma proliferation.	LEFTY2 LEFTY1	7.36e-06	3	55	2	25672326
Pubmed	Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.	LEFTY2 LEFTY1	7.36e-06	3	55	2	27655833
Pubmed	Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.	LEFTY2 LEFTY1	7.36e-06	3	55	2	37097539
Pubmed	Embryonic asymmetry: the left side gets all the best genes.	LEFTY2 LEFTY1	7.36e-06	3	55	2	9889116
Pubmed	Distribution and functional properties of human KCNH8 (Elk1) potassium channels.	KCNH8 KCNH3	7.36e-06	3	55	2	12890647
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	LUC7L DDX46 DDX50 RBBP6 CPSF6 SRRM2 PDCD4 RBM17	8.28e-06	653	55	8	33742100
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	LUC7L SRSF10 DDX46 PNN RBBP6 CPSF6 CDK13 SRRM2	9.45e-06	665	55	8	30457570
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	LUC7L SRSF10 DDX50 PNN CPSF6 CDK13 SRRM2 RBM17	9.97e-06	670	55	8	22990118
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	PNN RBBP6 CDK13 TNKS1BP1 TIMELESS SRRM2 PDCD4	1.41e-05	503	55	7	16964243
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	LENG8 DDX46 RBBP6 CPSF6 CDK13 SRRM2 RBM17	1.47e-05	506	55	7	30890647
Pubmed	Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.	LEFTY2 LEFTY1	1.47e-05	4	55	2	9348041
Pubmed	Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.	LEFTY2 LEFTY1	1.47e-05	4	55	2	15454269
Pubmed	Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes.	VANGL2 CELSR1	1.47e-05	4	55	2	33529151
Pubmed	Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.	LEFTY2 LEFTY1	1.47e-05	4	55	2	9708732
Pubmed	lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.	LEFTY2 LEFTY1	1.47e-05	4	55	2	9708731
Pubmed	Mouse U2af1-rs1 is a neomorphic imprinted gene.	ZRSR2P1 ZRSR2	1.47e-05	4	55	2	9001233
Pubmed	Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.	LEFTY2 LEFTY1	1.47e-05	4	55	2	8610011
Pubmed	The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.	LEFTY2 LEFTY1	1.47e-05	4	55	2	23544137
Pubmed	Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells.	PNN SRRM2	1.47e-05	4	55	2	14578391
Pubmed	Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.	VANGL2 CELSR1	1.47e-05	4	55	2	29463853
Pubmed	The role of the brachyury gene in heart development and left-right specification in the mouse.	LEFTY2 LEFTY1	1.47e-05	4	55	2	10349618
Pubmed	Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.	ZRSR2P1 ZRSR2	1.47e-05	4	55	2	7558001
Pubmed	Calaxin is required for cilia-driven determination of vertebrate laterality.	LEFTY2 LEFTY1	1.47e-05	4	55	2	31240264
Pubmed	Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2.	LEFTY2 LEFTY1	1.47e-05	4	55	2	9990851
Pubmed	Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.	LEFTY2 LEFTY1	1.47e-05	4	55	2	11448943
Pubmed	The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.	LEFTY2 LEFTY1	1.47e-05	4	55	2	17662710
Pubmed	The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness.	LEFTY2 LEFTY1	1.47e-05	4	55	2	9376323
Pubmed	Wnt3a-dependent and -independent protein interaction networks of chromatin-bound β-catenin in mouse embryonic stem cells.	LEFTY2 LEFTY1	1.47e-05	4	55	2	23592333
Pubmed	LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1.	LEFTY2 LEFTY1	1.47e-05	4	55	2	27606670
Pubmed	Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.	VANGL2 CELSR1	1.47e-05	4	55	2	16687519
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	LUC7L SRSF10 DDX46 PRPF38B	2.29e-05	104	55	4	31365120
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SRSF10 VTN DDX50 PNN RBBP6 CPSF6 SIPA1L3 BTBD10 TNKS1BP1 PDCD4	2.44e-05	1257	55	10	36526897
Pubmed	Lineage-specific functions of TET1 in the postimplantation mouse embryo.	LEFTY2 LEFTY1	2.45e-05	5	55	2	28504700
Pubmed	Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.	LEFTY2 LEFTY1	2.45e-05	5	55	2	11703930
Pubmed	Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development.	LEFTY2 LEFTY1	2.45e-05	5	55	2	15750185
Pubmed	Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.	VANGL2 CELSR1	2.45e-05	5	55	2	25128525
Pubmed	Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer.	LEFTY2 LEFTY1	2.45e-05	5	55	2	10385627
Pubmed	Regulation of cyclin D1 RNA stability by SNIP1.	SNIP1 PNN	2.45e-05	5	55	2	18794151
Pubmed	New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo.	VANGL2 CELSR1	2.45e-05	5	55	2	34463728
Pubmed	Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.	LEFTY2 LEFTY1	2.45e-05	5	55	2	15308665
Interaction	SRPK2 interactions	SNIP1 LUC7L SRSF10 DDX46 DDX50 PNN ZRSR2 RBBP6 CPSF6 CDK13 SIPA1L3 PRPF38B RSRC2 SRRM2 SRSF12 RBM17	2.43e-11	717	53	16	int:SRPK2
Interaction	CLK2 interactions	SNIP1 LUC7L SRSF10 PNN ZRSR2 RBBP6 CPSF6 SRRM2 SRSF12	1.90e-09	195	53	9	int:CLK2
Interaction	DHX8 interactions	LENG8 SNIP1 DDX46 PNN RBBP6 CPSF6 CDK13 RSRC2 SRRM2 RBM17	3.93e-09	292	53	10	int:DHX8
Interaction	PRPF40A interactions	SNIP1 LUC7L SRSF10 DDX46 VTN PNN CPSF6 CDK13 FMN1 MARK4 SRRM2	1.82e-08	446	53	11	int:PRPF40A
Interaction	SRSF1 interactions	SNIP1 LUC7L SRSF10 DDX46 VTN DDX50 ZRSR2 CPSF6 CDK13 SRRM2 SRSF12 RBM17	2.16e-08	570	53	12	int:SRSF1
Interaction	RAD18 interactions	LENG8 SNIP1 LUC7L ZRSR2P1 RBBP6 CPSF6 SIPA1L3 PRPF38B SRRM2 SRSF12 RBM17	2.34e-08	457	53	11	int:RAD18
Interaction	ZC3H18 interactions	LENG8 SNIP1 LUC7L SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 PRPF38B RSRC2 SRRM2 SRSF12 RBM17	3.89e-08	877	53	14	int:ZC3H18
Interaction	SRSF11 interactions	LUC7L SRSF10 DDX46 VTN PNN PRPF38B SRRM2 SRSF12	5.55e-08	203	53	8	int:SRSF11
Interaction	SRSF6 interactions	SNIP1 LUC7L SRSF10 DDX50 PNN RBBP6 CPSF6 CDK13 PRPF38B SRRM2 SRSF12	6.21e-08	503	53	11	int:SRSF6
Interaction	SAP18 interactions	VANGL2 SNIP1 SRSF10 VTN PNN RBBP6 CPSF6 PRPF38B SRRM2	9.15e-08	305	53	9	int:SAP18
Interaction	CLK3 interactions	SNIP1 LUC7L SRSF10 PNN RBBP6 PRPF38B SRRM2 SRSF12	1.03e-07	220	53	8	int:CLK3
Interaction	MECP2 interactions	VANGL2 LENG8 LUC7L SRSF10 DDX46 DDX50 PNN ZRSR2 RBBP6 CPSF6 PRPF38B TNKS1BP1 RSRC2 SRRM2 GNS RBM17	1.09e-07	1287	53	16	int:MECP2
Interaction	NKTR interactions	SNIP1 LUC7L PNN ZRSR2 CPSF6 ZNF707	1.30e-07	90	53	6	int:NKTR
Interaction	LUC7L interactions	VANGL2 LUC7L SRSF10 DDX50 PNN RBBP6 PRPF38B SRRM2	2.14e-07	242	53	8	int:LUC7L
Interaction	LUC7L2 interactions	SNIP1 LUC7L SRSF10 DDX46 PNN ZRSR2 CPSF6 SRRM2 SRSF12	3.15e-07	353	53	9	int:LUC7L2
Interaction	DDX23 interactions	SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 CDK13 RSRC2 SRRM2 RBM17	4.17e-07	480	53	10	int:DDX23
Interaction	SNRNP40 interactions	LENG8 SNIP1 SRSF10 GPBP1L1 DDX50 PNN RBBP6 CPSF6 ZNF316 SRRM2 RBM17	6.58e-07	637	53	11	int:SNRNP40
Interaction	JMJD6 interactions	LUC7L ZRSR2P1 DDX46 ZRSR2 CPSF6 PRPF38B RSRC2	1.05e-06	205	53	7	int:JMJD6
Interaction	ACIN1 interactions	SNIP1 LUC7L PNN RBBP6 CPSF6 BTBD10 SRRM2 GNS	1.12e-06	301	53	8	int:ACIN1
Interaction	PNN interactions	VANGL2 SNIP1 LUC7L SRSF10 PNN RBBP6 CPSF6 SRRM2	1.14e-06	302	53	8	int:PNN
Interaction	ZRSR2P1 interactions	ZRSR2P1 ZRSR2 RBM17	1.43e-06	9	53	3	int:ZRSR2P1
Interaction	SRSF7 interactions	SNIP1 LUC7L SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 SRRM2	1.48e-06	425	53	9	int:SRSF7
Interaction	BARD1 interactions	LUC7L SRSF10 DDX50 PNN CPSF6 CDK13 SRRM2 RBM17	1.89e-06	323	53	8	int:BARD1
Interaction	TRA2A interactions	SNIP1 LUC7L SRSF10 PNN RBBP6 CPSF6 SRRM2 SRSF12	2.22e-06	330	53	8	int:TRA2A
Interaction	SRRM4 interactions	SNIP1 LUC7L ZRSR2P1 ZRSR2	2.64e-06	37	53	4	int:SRRM4
Interaction	SRPK1 interactions	LUC7L SRSF10 DDX46 PNN ZRSR2 CPSF6 RSRC2 SRRM2 SRSF12	3.80e-06	477	53	9	int:SRPK1
Interaction	NFKBIL1 interactions	VANGL2 LUC7L SRSF10 PNN SRRM2	4.52e-06	93	53	5	int:NFKBIL1
Interaction	U2AF2 interactions	LUC7L ZRSR2P1 SRSF10 DDX46 PNN ZRSR2 CPSF6 SRRM2 SRSF12 RBM17	6.42e-06	651	53	10	int:U2AF2
Interaction	SRSF10 interactions	SNIP1 LUC7L SRSF10 VTN PNN CPSF6 SRSF12	6.69e-06	271	53	7	int:SRSF10
Interaction	SNRPF interactions	SNIP1 LUC7L GPBP1L1 PNN ZRSR2 CPSF6 SRRM2 RBM17	6.90e-06	385	53	8	int:SNRPF
Interaction	SNRNP70 interactions	SNIP1 LUC7L SRSF10 DDX50 PNN RBBP6 CPSF6 PRPF38B RSRC2 SRRM2 SRSF12 RBM17	7.16e-06	984	53	12	int:SNRNP70
Interaction	MYCN interactions	LENG8 SNIP1 LUC7L SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 CDK13 PRPF38B SRRM2 SRSF12 RBM17	8.41e-06	1373	53	14	int:MYCN
Interaction	GSPT2 interactions	SRSF10 PNN RBBP6 SRRM2 SRSF12	9.00e-06	107	53	5	int:GSPT2
Interaction	UQCR11 interactions	SNIP1 DDX46 PRPF38B RSRC2	1.13e-05	53	53	4	int:UQCR11
Interaction	SNRPD2 interactions	SNIP1 LUC7L DDX46 PNN ZRSR2 CPSF6 SRRM2 RBM17	1.17e-05	414	53	8	int:SNRPD2
Interaction	IFI6 interactions	SNIP1 DDX46 PRPF38B RSRC2	1.22e-05	54	53	4	int:IFI6
Interaction	SNIP1 interactions	SNIP1 SRSF10 DDX50 PNN CDK13 SRRM2 SRSF12 RBM17	1.23e-05	417	53	8	int:SNIP1
Interaction	SRSF4 interactions	SNIP1 SRSF10 PNN RBBP6 CDK13 SRRM2 SRSF12	1.30e-05	300	53	7	int:SRSF4
Interaction	RNPS1 interactions	SNIP1 LUC7L SRSF10 DDX46 PNN RBBP6 CPSF6 SRRM2	1.41e-05	425	53	8	int:RNPS1
Interaction	PPIG interactions	SNIP1 LUC7L PNN RBBP6 CPSF6	2.07e-05	127	53	5	int:PPIG
Interaction	RBM25 interactions	SNIP1 LUC7L SRSF10 VTN CPSF6 MARK4 SRRM2	2.08e-05	323	53	7	int:RBM25
Interaction	RBM17 interactions	SNIP1 ZRSR2P1 DDX46 ZRSR2 TIMELESS RBM17	2.25e-05	218	53	6	int:RBM17
Interaction	CLK1 interactions	SRSF10 PNN ZRSR2 RBBP6 SRRM2 SRSF12	2.31e-05	219	53	6	int:CLK1
Interaction	NKAP interactions	SNIP1 LUC7L PNN CPSF6 SRRM2	2.49e-05	132	53	5	int:NKAP
Interaction	IFI27L1 interactions	SNIP1 DDX46 PRPF38B RSRC2	2.56e-05	65	53	4	int:IFI27L1
Interaction	FOLR1 interactions	LUC7L DDX46 RBBP6 CPSF6 PRPF38B SRRM2	2.82e-05	227	53	6	int:FOLR1
Interaction	SF3A1 interactions	SNIP1 DDX46 VTN PNN ZRSR2 RBBP6 SRRM2 RBM17	2.95e-05	471	53	8	int:SF3A1
Interaction	CSNK2A1 interactions	LUC7L SRSF10 VTN PNN CPSF6 TNKS1BP1 CNKSR2 SRRM2 PDCD4 RBM17 ZNF707	3.15e-05	956	53	11	int:CSNK2A1
Interaction	SNRPD1 interactions	SNIP1 LUC7L DDX46 CPSF6 SRRM2 PDCD4 RBM17	3.30e-05	347	53	7	int:SNRPD1
Interaction	CWC22 interactions	SNIP1 PNN CPSF6 SRRM2 PDCD4	3.42e-05	141	53	5	int:CWC22
Interaction	PAIP1 interactions	SNIP1 SRSF10 PNN SRRM2 PDCD4	4.04e-05	146	53	5	int:PAIP1
Interaction	LEFTY1 interactions	LEFTY2 LEFTY1	4.06e-05	4	53	2	int:LEFTY1
Interaction	LEFTY2 interactions	LEFTY2 LEFTY1	4.06e-05	4	53	2	int:LEFTY2
Interaction	SMC5 interactions	LENG8 SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 TIMELESS SRRM2 SRSF12 RBM17	4.75e-05	1000	53	11	int:SMC5
Interaction	PUF60 interactions	SRSF10 DDX46 DDX50 PNN CPSF6 SRRM2 RBM17	4.87e-05	369	53	7	int:PUF60
Interaction	SNRPB interactions	SNIP1 DDX46 PNN ZRSR2 RBBP6 CPSF6 SRRM2 RBM17	5.71e-05	517	53	8	int:SNRPB
Interaction	SNRPD3 interactions	SNIP1 LUC7L DDX46 ZRSR2 CPSF6 SRRM2 RBM17	5.86e-05	380	53	7	int:SNRPD3
Interaction	TNIP1 interactions	LENG8 SNIP1 LUC7L DDX46 DDX50 PNN RBBP6 CPSF6 CDK13 SRRM2 PDCD4 RBM17	5.90e-05	1217	53	12	int:TNIP1
Interaction	PSENEN interactions	SNIP1 DDX46 PRPF38B RSRC2	6.10e-05	81	53	4	int:PSENEN
Interaction	MEN1 interactions	LENG8 LUC7L SRSF10 DDX46 DDX50 PNN RBBP6 CPSF6 TNKS1BP1 SRRM2 RBM17	6.16e-05	1029	53	11	int:MEN1
Interaction	CPSF6 interactions	LENG8 SRSF10 DDX50 PNN RBBP6 CPSF6 SRRM2 GNS	6.44e-05	526	53	8	int:CPSF6
Interaction	MAGOH interactions	SNIP1 SRSF10 PNN CPSF6 SRRM2 SRSF12	6.54e-05	264	53	6	int:MAGOH
Interaction	HDLBP interactions	LENG8 LUC7L SRSF10 VTN PNN CPSF6 SIPA1L3 PRPF38B EIF2AK4 RBM17	6.65e-05	855	53	10	int:HDLBP
Interaction	CDC5L interactions	SNIP1 LUC7L DDX46 VTN PNN RBBP6 CPSF6 TNKS1BP1 SRRM2 RBM17	6.65e-05	855	53	10	int:CDC5L
Interaction	SF3A2 interactions	SNIP1 DDX46 PNN CPSF6 SRRM2 RBM17	7.87e-05	273	53	6	int:SF3A2
Interaction	PHF5A interactions	SNIP1 DDX46 ZRSR2 CPSF6 RBM17	8.56e-05	171	53	5	int:PHF5A
Interaction	PPIE interactions	SNIP1 LUC7L PNN CPSF6 SRRM2 RBM17	9.41e-05	282	53	6	int:PPIE
Interaction	EZH1 interactions	SNIP1 DDX46 RBBP6 PRPF38B	1.00e-04	92	53	4	int:EZH1
Interaction	LINC02910 interactions	SNIP1 DDX46 PRPF38B RSRC2	1.14e-04	95	53	4	int:LINC02910
Interaction	SNRPA1 interactions	SNIP1 DDX46 VTN PNN SRRM2 RBM17	1.32e-04	300	53	6	int:SNRPA1
Interaction	API5 interactions	PNN CPSF6 RSRC2 SRRM2 PDCD4	1.34e-04	188	53	5	int:API5
Interaction	SF3B6 interactions	SNIP1 DDX46 VTN ZRSR2 RBM17	1.55e-04	194	53	5	int:SF3B6
Interaction	ANKRD50 interactions	SNIP1 DDX46 RBBP6 PRPF38B	1.87e-04	108	53	4	int:ANKRD50
Interaction	SRRM2 interactions	SNIP1 LUC7L DDX50 PNN RBBP6 CPSF6 SRRM2	1.97e-04	462	53	7	int:SRRM2
Interaction	NAA40 interactions	LENG8 DDX46 DDX50 PNN RBBP6 CPSF6 PRPF38B TNKS1BP1 PDCD4 RBM17	2.01e-04	978	53	10	int:NAA40
Interaction	CLK4 interactions	SRSF10 RBBP6 SRRM2	2.11e-04	44	53	3	int:CLK4
Interaction	SON interactions	SNIP1 RBBP6 CPSF6 SRRM2 RBM17	2.14e-04	208	53	5	int:SON
Interaction	PIP4K2A interactions	LENG8 GPBP1L1 PNN PRPF38B SRRM2	2.55e-04	216	53	5	int:PIP4K2A
Interaction	RBBP6 interactions	LUC7L PNN RBBP6 CPSF6 SRRM2	2.55e-04	216	53	5	int:RBBP6
Interaction	SNRPA interactions	LENG8 SNIP1 LUC7L SRSF10 PNN RBBP6 SRRM2	2.55e-04	482	53	7	int:SNRPA
Interaction	RNASEH1 interactions	LUC7L DDX50 CDK13	2.57e-04	47	53	3	int:RNASEH1
Interaction	SF3A3 interactions	SNIP1 DDX46 PNN ZRSR2 SRRM2 RBM17	2.60e-04	340	53	6	int:SF3A3
Interaction	SRRM1 interactions	SNIP1 LUC7L PNN CPSF6 EIF2AK4 SRRM2	2.94e-04	348	53	6	int:SRRM1
Interaction	PURG interactions	LENG8 SRSF10 DDX50 RBBP6 CDK13	2.95e-04	223	53	5	int:PURG
Interaction	OASL interactions	LUC7L DDX50 ZNF316 ZNF865 RBM17	2.95e-04	223	53	5	int:OASL
Interaction	MAGEB2 interactions	LENG8 LUC7L DDX50 RBBP6 CDK13 SRSF12	2.99e-04	349	53	6	int:MAGEB2
Interaction	RNF151 interactions	LUC7L DDX50 PNN SRRM2	3.07e-04	123	53	4	int:RNF151
Interaction	CIT interactions	LUC7L SRSF10 DDX46 VTN DDX50 PNN RBBP6 PRPF38B TNKS1BP1 SRRM2 SRSF12 RBM17	3.08e-04	1450	53	12	int:CIT
Interaction	EIF4A3 interactions	SNIP1 SRSF10 PNN RBBP6 CPSF6 SRRM2 PDCD4	3.15e-04	499	53	7	int:EIF4A3
Interaction	DHX15 interactions	SNIP1 SRSF10 DDX46 VTN SRRM2 USP3 RBM17	3.26e-04	502	53	7	int:DHX15
Interaction	YWHAG interactions	SNIP1 LUC7L SRSF10 GPBP1L1 PNN SIPA1L3 MARK4 PRPF38B SRRM2 PDCD4 SRSF12	3.37e-04	1248	53	11	int:YWHAG
Interaction	H2AJ interactions	SNIP1 DDX46 RBBP6 PRPF38B	3.47e-04	127	53	4	int:H2AJ
Interaction	ANAPC15 interactions	SNIP1 DDX46 PRPF38B RSRC2	3.57e-04	128	53	4	int:ANAPC15
Interaction	ZCCHC10 interactions	VANGL2 SNIP1 RBBP6 CPSF6 SRRM2	3.83e-04	236	53	5	int:ZCCHC10
Interaction	JPH3 interactions	SNIP1 DDX46 PRPF38B	4.09e-04	55	53	3	int:JPH3
Interaction	LLGL2 interactions	RBBP6 FMN1 ZNF316 ZNF707	4.13e-04	133	53	4	int:LLGL2
Interaction	LARP4B interactions	SRSF10 PNN RBBP6 SRRM2 SRSF12	4.14e-04	240	53	5	int:LARP4B
Interaction	RNF113A interactions	SNIP1 LUC7L DDX46 DDX50 PNN RBBP6 CDK13 SRRM2	4.20e-04	692	53	8	int:RNF113A
Interaction	ACTC1 interactions	LENG8 SNIP1 DDX46 RBBP6 CPSF6 CDK13 SRRM2 RBM17	4.28e-04	694	53	8	int:ACTC1
Interaction	KCNH4 interactions	KCNH8 KCNH3	4.40e-04	12	53	2	int:KCNH4
Cytoband	1q42.1	LEFTY2 LEFTY1	9.23e-05	12	55	2	1q42.1
GeneFamily	RNA binding motif containing	ZRSR2P1 SRSF10 ZRSR2 CPSF6 SRSF12 RBM17	1.17e-06	213	30	6	725
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF10 SRSF12	1.74e-04	12	30	2	737
GeneFamily	Zinc fingers CCCH-type	ZRSR2P1 ZRSR2	1.53e-03	35	30	2	73
GeneFamily	Potassium voltage-gated channels	KCNH8 KCNH3	2.00e-03	40	30	2	274
GeneFamily	DEAD-box helicases	DDX46 DDX50	2.20e-03	42	30	2	499
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF316 ZNF721 ZFP92 ZNF865 ZNF707	6.08e-03	718	30	5	28
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN	LENG8 SRSF10 DDX50 PNN RBBP6 RSRC2 USP3 PDCD4	3.15e-06	432	55	8	M41149
Coexpression	GSE44649_NAIVE_VS_ACTIVATED_CD8_TCELL_MIR155_KO_UP	DDX50 PNN ZRSR2 GNS RBM17	6.28e-05	200	55	5	M9776
Coexpression	TESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_DN	LEFTY2 LEFTY1	6.45e-05	6	55	2	M1764
Coexpression	TESAR_ALK_TARGETS_HUMAN_ES_4D_DN	LEFTY2 LEFTY1	6.45e-05	6	55	2	M16516
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#3	ABHD15 SRSF10 DDX46 DDX50 PNN PRPF38B EIF2AK4	8.34e-05	432	52	7	Facebase_RNAseq_e10.5_Maxillary Arch_1000_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_100	LEFTY2 PNN FMN1 PRPF38B	1.01e-04	99	52	4	Facebase_RNAseq_e10.5_Maxillary Arch_100
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	DDX46 PNN ZRSR2 FMN1 PRPF38B RSRC2 RBM17	1.39e-04	469	52	7	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3	DDX46 PNN FMN1 PRPF38B CNKSR2 ZFP92 USP3 SRSF12 RBM17	1.72e-04	834	52	9	Facebase_RNAseq_e10.5_Mandibular Arch_2500_K3
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	DDX46 PNN ZRSR2 RBBP6 PRPF38B ZNF721 RSRC2 SRRM2	1.20e-10	197	55	8	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	SRSF10 PNN RBBP6 CDK13 RSRC2 SRRM2	1.73e-07	200	55	6	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SRSF10 PNN RSRC2 SRRM2 USP3	4.45e-06	197	55	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SRSF10 PNN RSRC2 SRRM2 USP3	4.57e-06	198	55	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SRSF10 PNN RSRC2 SRRM2 USP3	4.57e-06	198	55	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LUC7L SRSF10 PNN CDK13 PARP15	4.68e-06	199	55	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SRSF10 PNN CDK13 RSRC2 SRRM2	4.79e-06	200	55	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	SRSF10 RSRC2 SRRM2 PARP15	9.06e-05	191	55	4	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	COVID-19_Severe-PLT_4\|World / Disease Group and Platelet Clusters	SRSF10 RSRC2 PDCD4 RBM17	1.00e-04	196	55	4	ad43efdd4d73b6615f65f06a315b33576e317473
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SRSF10 PNN CDK13 PARP15	1.02e-04	197	55	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	10x5'v1-week_14-16-Lymphocytic_B-B_lineage-pre_B_progenitor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ABHD15 SRSF10 PNN PARP15	1.02e-04	197	55	4	78122e1fb80e0ac3084dd4f7c551996330a701df
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SRSF10 PNN CDK13 RSRC2	1.04e-04	198	55	4	5f465cf5c7493e32d9afe9e9d05757d0a95acc33
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SRSF10 PNN CDK13 RSRC2	1.04e-04	198	55	4	77ce3fe1ab161c0faf8987e73a64ab61294b9255
ToppCell	COVID-19_Severe-PLT_4\|COVID-19_Severe / Disease Group and Platelet Clusters	SRSF10 RSRC2 PDCD4 RBM17	1.04e-04	198	55	4	abfddbee99ef8c7719e6e6f62571e9be030e4acf
ToppCell	COVID-19_Mild-PLT_4\|COVID-19_Mild / Disease Group and Platelet Clusters	SRSF10 RSRC2 PDCD4 RBM17	1.04e-04	198	55	4	3d8c33dba759df0974aeb2b9a6b5167ae7a18e1f
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pre_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ABHD15 SRSF10 PNN RSRC2	1.06e-04	199	55	4	dd94e42b62af7cbd69c472681d3c758552694ae2
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|megakaryocytic / Lineage and Cell class	SRSF10 DDX46 PNN SRRM2	1.06e-04	199	55	4	99a65887d3c8a2cde26693dd74404b101bba9d58
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	PNN FMN1 USP3 GNS	1.08e-04	200	55	4	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
Computational	Neighborhood of RBBP6	DDX50 PNN RBBP6 RSRC2	3.00e-05	70	28	4	GNF2_RBBP6
Computational	Neighborhood of HDAC1	SRSF10 DDX46 DDX50 RBBP6	1.76e-04	110	28	4	GNF2_HDAC1
Computational	Neighborhood of FBL	SRSF10 DDX50 RBBP6 CPSF6	5.19e-04	146	28	4	GNF2_FBL
Disease	NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO	VANGL2 CELSR1	8.15e-05	8	51	2	C3891448
Disease	interleukin-2 receptor subunit alpha measurement	PRPF38B RBM17	6.02e-04	21	51	2	EFO_0010587

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRDRHRSKSRDGGRG	VANGL2	26	Q9ULK5
GGHERSRDRRRSSDR	BTBD10	56	Q9BSF8
NGKHRANSSGRSRRE	EIF2AK4	236	Q9P2K8
RRARRGTSGRGSLKF	CELSR1	231	Q9NYQ6
HRRRDGQRGGSEASK	CDK13	216	Q14004
KGLSRHRASFLGGRR	ABHD15	426	Q6UXT9
HGSRRQGKERQGDRS	FMN1	381	Q68DA7
RSKGKSRRSRGHHDR	IQCH	236	Q86VS3
QKRRGCRGSRRRHAN	H2BW2	36	P0C1H6
CRGSRRRHANRRGDS	H2BW2	41	P0C1H6
RRHANRRGDSFGDSF	H2BW2	46	P0C1H6
GRARSKGFNANRRRS	KCNH3	156	Q9ULD8
RKRGHSGDRRSPSRR	MMTAG2	241	Q9BU76
GNRGARKASRRSSSR	PARP15	46	Q460N3
QRSHGDRSRGKRFSQ	LEFTY1	66	O75610
RGHRRASRDRSAKYK	LUC7L	311	Q9NQ29
GEGRFGVSRRRHNSS	GPBP1L1	36	Q9HC44
RALGRSSHRRRTGES	GARIN4	431	Q8IYT1
DRGRGRAQRGKRHDL	LENG8	471	Q96PV6
RRLRKNSSRDSGRGD	PDCD4	61	Q53EL6
SRSRSRGRGHNRDRK	PNN	631	Q9H307
RGRGKSRNYRSRSRS	RBBP6	736	Q7Z6E9
RFRGSGKENSRHRCG	CPT1C	771	Q8TCG5
RGRSRACTGRSKRHR	FRG2B	146	Q96QU4
GSGSRRERSRERDHS	CPSF6	486	Q16630
EARYGSQHRKQRRSR	DMBX1	61	Q8NFW5
SGNRNRSRSGGHKRS	DDX50	721	Q9BQ39
RRSHGDRSRGKRFSQ	LEFTY2	66	O00292
SPGRSRRGKTRHRKA	MAP3K12	536	Q12852
FSNRGSVRTRRFSKH	GNS	536	P15586
RSTFHGGQVRDRRAG	MARK4	566	Q96L34
RHYRKRSASRGRSGS	DDX46	6	Q7L014
LARKSRPRGFHRSRD	MLNR	371	O43193
NEGRKHRSRSRSKEG	RSRC2	56	Q7L4I2
ARSGHRGNRARGVSR	SNIP1	61	Q8TAD8
RGQRGDSRSPSHKRR	SRRM2	2721	Q9UQ35
ASSGSKAFHRLSRRR	SIPA1L3	131	O60292
RRNFGSRGRSRSKSL	SRSF12	171	Q8WXF0
RRRSGHYDGRTSRKL	CNKSR2	106	Q8WXI2
TRALQRGNRHSRFGG	TIMELESS	266	Q9UNS1
RERAREGSSFRKGFR	ZNF707	111	Q96C28
GKAFRGRSGLSQHRR	ZFP92	326	A6NM28
GRGFGRRETLKRHER	ZNF865	556	P0CJ78
GRPRRSRSHSDNDRF	SRSF10	151	O75494
KRRKDRHEASGFARR	RBM17	136	Q96I25
RERKHRSRSRSRNAG	PRPF38B	431	Q5VTL8
GKAFSRSRNLTTHRR	ZNF721	691	Q8TF20
YRSRANLGRKRGHRA	TNKS1BP1	1571	Q9C0C2
RLDGHSRRATRRNSF	NEURL1B	51	A8MQ27
SRNGSKVRYRRAASH	STIMATE	236	Q86TL2
RNGKTAGRRTYHTRS	USP3	196	Q9Y6I4
RGFAQRSNLAKHRRG	ZNF316	866	A6NFI3
RRRKKRRQGRCGSSH	nan	326	A8MUI8
SRCRSRGRRKSGNRD	ZRSR2P1	456	Q15695
RGRRKSGNRDRTVQS	ZRSR2P1	461	Q15695
ENNKEGSFRRRGRRS	WSCD1	521	Q658N2
HTGDRLGRRSSSKRA	TMC2	26	Q8TDI7
RKGYRSQRGHSRGRN	VTN	376	P04004
RNGESERKSSRHRGK	ZRSR2	391	Q15696
KGRSRAGTHFDSARR	KCNH8	151	Q96L42