Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	6.54e-05	2	162	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	6.54e-05	2	162	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	6.54e-05	2	162	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	6.54e-05	2	162	2	GO:0004354
GeneOntologyMolecularFunction	adenylosuccinate synthase activity	ADSS2 ADSS1	6.54e-05	2	162	2	GO:0004019
GeneOntologyMolecularFunction	complement component C4b binding	CR1 MASP2	1.95e-04	3	162	2	GO:0001855
GeneOntologyMolecularFunction	phosphate ion binding	ADSS2 PTPRF ADSS1	2.72e-04	16	162	3	GO:0042301
GeneOntologyMolecularFunction	histone methyltransferase activity	NSD2 SETBP1 PRDM13 KMT2A DOT1L	2.79e-04	71	162	5	GO:0042054
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	NSD2 SETBP1 KMT2A DOT1L	4.40e-04	44	162	4	GO:0140938
GeneOntologyMolecularFunction	cupric ion binding	ATP13A2 MUC2	6.44e-04	5	162	2	GO:1903135
GeneOntologyCellularComponent	costamere	FLNC ANK2 AHNAK AHNAK2	2.39e-05	22	164	4	GO:0043034
Domain	AT_hook	BAZ2A SETBP1 KMT2A DOT1L	9.38e-06	16	163	4	PF02178
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	7.57e-05	2	163	2	PF02812
Domain	Adenylsucc_synt	ADSS2 ADSS1	7.57e-05	2	163	2	SM00788
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	7.57e-05	2	163	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	7.57e-05	2	163	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	7.57e-05	2	163	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	7.57e-05	2	163	2	PF00208
Domain	ADENYLOSUCCIN_SYN_2	ADSS2 ADSS1	7.57e-05	2	163	2	PS00513
Domain	Adenylosuccin_syn_GTP-bd	ADSS2 ADSS1	7.57e-05	2	163	2	IPR018220
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	7.57e-05	2	163	2	IPR033922
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	7.57e-05	2	163	2	PS00074
Domain	Adenylsucc_synt	ADSS2 ADSS1	7.57e-05	2	163	2	PF00709
Domain	Adenylosuccin_syn_Lys_AS	ADSS2 ADSS1	7.57e-05	2	163	2	IPR033128
Domain	ELFV_dehydrog	GLUD1 GLUD2	7.57e-05	2	163	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	7.57e-05	2	163	2	IPR033524
Domain	Adenylosuccinate_synthetase	ADSS2 ADSS1	7.57e-05	2	163	2	IPR001114
Domain	ADENYLOSUCCIN_SYN_1	ADSS2 ADSS1	7.57e-05	2	163	2	PS01266
Domain	AT_hook	BAZ2A SETBP1 KMT2A DOT1L	8.39e-05	27	163	4	SM00384
Domain	AT_hook_DNA-bd_motif	BAZ2A SETBP1 KMT2A DOT1L	8.39e-05	27	163	4	IPR017956
Domain	CH	CFAP47 FLNB FLNC MICALL1 PLS3	3.65e-04	70	163	5	PF00307
Domain	-	CFAP47 FLNB FLNC MICALL1 PLS3	3.90e-04	71	163	5	1.10.418.10
Domain	CH	CFAP47 FLNB FLNC MICALL1 PLS3	4.43e-04	73	163	5	PS50021
Domain	Kinesin-like_KIF1-typ	KIF1A KIF1B	4.49e-04	4	163	2	IPR022140
Domain	KIF1B	KIF1A KIF1B	4.49e-04	4	163	2	PF12423
Domain	CH-domain	CFAP47 FLNB FLNC MICALL1 PLS3	5.02e-04	75	163	5	IPR001715
Domain	BRCT	LIG3 MDC1 REV1	8.90e-04	22	163	3	SM00292
Domain	-	STARD13 CERT1 COQ10A	1.02e-03	23	163	3	3.30.530.20
Domain	ACTININ_2	FLNB FLNC PLS3	1.02e-03	23	163	3	PS00020
Domain	ACTININ_1	FLNB FLNC PLS3	1.02e-03	23	163	3	PS00019
Domain	-	LIG3 MDC1 REV1	1.02e-03	23	163	3	3.40.50.10190
Domain	Actinin_actin-bd_CS	FLNB FLNC PLS3	1.02e-03	23	163	3	IPR001589
Domain	START-like_dom	STARD13 CERT1 COQ10A	1.02e-03	23	163	3	IPR023393
Domain	PHD	NSD2 PHF2 BAZ2A KMT2A RAI1	1.10e-03	89	163	5	SM00249
Domain	Kinesin_assoc	KIF1A KIF1B	1.11e-03	6	163	2	PF16183
Domain	PAK_BD	PAK4 PAK2	1.11e-03	6	163	2	IPR033923
Domain	Kinesin-like	KIF1A KIF1B	1.11e-03	6	163	2	IPR022164
Domain	Kinesin_assoc	KIF1A KIF1B	1.11e-03	6	163	2	IPR032405
Domain	DUF3694	KIF1A KIF1B	1.11e-03	6	163	2	PF12473
Domain	Znf_PHD	NSD2 PHF2 BAZ2A KMT2A RAI1	1.21e-03	91	163	5	IPR001965
Domain	BRCT	LIG3 MDC1 REV1	1.46e-03	26	163	3	PS50172
Domain	ZF_PHD_2	NSD2 PHF2 BAZ2A KMT2A RAI1	1.47e-03	95	163	5	PS50016
Domain	ZF_PHD_1	NSD2 PHF2 BAZ2A KMT2A RAI1	1.54e-03	96	163	5	PS01359
Domain	WASP_C	PAK4 PAK2	1.54e-03	7	163	2	IPR011026
Domain	DNA_methylase_N6_adenine_CS	METTL4 ZCCHC4	1.54e-03	7	163	2	IPR002052
Domain	BRCT_dom	LIG3 MDC1 REV1	1.82e-03	28	163	3	IPR001357
Domain	FHA	KIF1A KIF1B MDC1	1.82e-03	28	163	3	SM00240
Domain	ATPase_AAA_CS	NSF PSMC1 AFG3L2	2.02e-03	29	163	3	IPR003960
Domain	N6_MTASE	METTL4 ZCCHC4	2.05e-03	8	163	2	PS00092
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RAD51 FLNC ABL1 PPRC1 TMEM8B NSD2 TASP1 ANKHD1 TMEM127 ATP13A2 LYST MICALL1 PPP1R26 KANSL3 NCOR1 URB1 ARHGEF40 PTPRF ZNF592 AHNAK DOT1L MAPKBP1 PC RAI1 AHNAK2	1.17e-10	1105	166	25	35748872
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	FLNB ANK2 NSF KIF1B PAK4 SHB PSMC1 MICALL1 RPL10A NUP155 ADSS2 AHNAK AFG3L2 PAK2 CRYBG3 SEPTIN7 PLS3 RPL8	9.71e-09	708	166	18	39231216
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 FLNB FLNC KIF1A NSD2 NOL6 ANKHD1 RPL10A URB1 NUP155 BAZ2A AHNAK MDC1 KMT2A RPL8 RBM34 RAI1	1.82e-08	653	166	17	22586326
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	KIF1A BMP2K NSF KIF1B GRIN2A GSN RPL10A ACSL1 PHF2 HSPA12A SETBP1 GLUD1 GLUD2 SEPTIN7 PC RPL8	5.61e-08	621	166	16	22794259
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	HAUS5 ANKHD1 CBL NCOR1 ALMS1 BAZ2A AHNAK MDC1 TPX2 PAK2 KMT2A DOT1L ZNF598 PC PLS3	6.99e-08	549	166	15	38280479
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NSD2 PAK4 HAUS5 PCDHA3 ANKHD1 CEMIP2 STAB1 MICALL1 KANSL3 NUP155 ZNF592 SETBP1 MDC1 RAI1	2.86e-07	529	166	14	14621295
Pubmed	Human transcription factor protein interaction networks.	HDAC5 RBMS1 PSMC1 HMGB2 ANKHD1 RPL10A KANSL3 ZNF462 PHF2 NCOR1 LIG3 ALMS1 ZNF592 NFATC4 MDC1 GLUD1 SLC25A10 TPX2 MARF1 KMT2A DOT1L RBM34 RAI2	3.56e-07	1429	166	23	35140242
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 FLNB FLNC NOL6 PSMC1 ANKHD1 RPL10A ACSL1 LIG3 NAA35 URB1 ARHGEF40 NUP155 ADSS2 BAZ2A AHNAK MDC1 AFG3L2 HLTF RPL8 RBM34 AHNAK2	5.53e-07	1353	166	22	29467282
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ANK2 PAK4 TACC2 ANKHD1 RPL10A LIG3 ALMS1 BAZ2A AHNAK GLUD1 AFG3L2 TPX2 PAK2 KMT2A ZNF598 PC RPL8 AHNAK2	5.95e-07	934	166	18	33916271
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEFSEC KIF1A BMP2K NSF NSD2 RBMS1 NOL6 TASP1 PSMC1 ANKHD1 PHF2 URB1 ZNF592 BAZ2A MDC1 AFG3L2 SLC25A10 TPX2 HLTF RBM5 KMT2A ZNF598 PLS3	7.93e-07	1497	166	23	31527615
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	CFAP47 TPP2 FLNB FLNC NSF PSMC1 RPL10A NUP155 ALMS1 AHNAK TPX2 SEPTIN7 RPL8	8.22e-07	494	166	13	26831064
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK4 ABL1 KIF1B PAK4 CBL LYST CDC14A MICALL1 VPS13D MYLK3 ALMS1 AHNAK KMT2A CRYBG3 ZNF598 PC AHNAK2	8.97e-07	861	166	17	36931259
Pubmed	Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models.	RAG1 FOXN1 LYST	1.06e-06	5	166	3	23885715
Pubmed	p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1.	PAK4 LEP NCOR1	1.06e-06	5	166	3	37591884
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	NSD2 TRUB1 ZNF462 PHF2 LIG3 ZNF592 BAZ2A MDC1 TPX2 HLTF KMT2A DOT1L RBM34 RAI1	1.48e-06	608	166	14	36089195
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STARD13 FLNB FLNC ANK2 PPRC1 NSD2 NOL6 SHB LPCAT4 HMGB2 ASIC5 LYST RYR2 GRPEL2 NCOR1 AHNAK GLUD1 GLUD2 MARF1 RBM5 KMT2A RAI1	1.58e-06	1442	166	22	35575683
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	FLNB NSD2 HAUS5 HMGB2 PHF2 LIG3 ALMS1 ZNF592 AHNAK AFG3L2 GLUD2 TPX2 KMT2A RAI1	2.94e-06	645	166	14	25281560
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	FLNB NOL6 GSN RPL10A ZNF462 NCOR1 URB1 ZNF592 MDC1 SLC25A10 TPX2 RBM5 KMT2A DOT1L RPL8 RBM34	3.36e-06	847	166	16	35850772
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NSD2 RBMS1 NOL6 HMGB2 RPL10A PHF2 NCOR1 LIG3 BAZ2A AHNAK MDC1 TPX2 MARF1 KMT2A SEPTIN7 PC RAI1	3.56e-06	954	166	17	36373674
Pubmed	Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation.	RNF213 RNF13 GLUD1	3.69e-06	7	166	3	34269483
Pubmed	SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.	AHNAK HLTF AHNAK2	3.69e-06	7	166	3	23415230
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	RAG1 FLNB FLNC ABL1 ANK2 PCDHA3 LIG3 URB1 BAZ2A TPX2	4.52e-06	329	166	10	17474147
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FLNB FLNC KIF1A NSF PSMC1 ANKHD1 CDC14A GSN RPL10A ACSL1 NUP155 PTPRF FLAD1 GLUD1 AFG3L2 ZNF598 PLS3	4.68e-06	974	166	17	28675297
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNB KIF1A NSF NSD2 NOL6 PSMC1 ANKHD1 RPL10A PHF2 LIG3 URB1 NUP155 ADSS2 MDC1 GLUD1 RBM5 SEPTIN7 PC PLS3 RPL8 RBM34	4.76e-06	1425	166	21	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TPP2 FLNB FLNC ANK2 NSF KIF1B PSMC1 DGKB GRIN2A GSN RPL10A HSPA12A GLUD1 AFG3L2 GLUD2 KMT2A SEPTIN7 PC PLS3 RPL8 MAPK8IP2	5.08e-06	1431	166	21	37142655
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	BMP2K NSF NOL6 PSMC1 RPL10A KANSL3 PHF2 NCOR1 BAZ2A AHNAK GLUD1 AFG3L2 SLC25A10 HLTF PAK2 FADS2 KMT2A PC RPL8 RBM34	5.32e-06	1318	166	20	30463901
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TPP2 FLNB BMP2K NSF NOL6 PSMC1 RNF213 GSN LIG3 URB1 FBXO6 NUP155 ADSS2 AHNAK MDC1 AFG3L2 HLTF KMT2A PLS3 RBM34 AHNAK2	5.59e-06	1440	166	21	30833792
Pubmed	Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.	LEP GLUD1 GLUD2	5.88e-06	8	166	3	34857752
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RAD51 FLNB HDAC5 ANKHD1 ZNF462 NCOR1 ALMS1 ZNF592 AHNAK CRYBG3 PC	5.91e-06	418	166	11	34709266
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NSD2 INPP5K HAUS5 LPCAT4 RNF213 ANKHD1 PHF2 NAA35 ZNF469 ARHGEF40 ALMS1 ZNF592 BAZ2A AFG3L2 CRYBG3 ZDHHC13 RAI1 WDR72	7.15e-06	1116	166	18	31753913
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	NSD2 NOL6 PSMC1 LIG3 URB1 BAZ2A MDC1 PLS3 RBM34 RAI1	7.58e-06	349	166	10	25665578
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TOB2 HDAC5 INPP5K NCOR1 ZNF469 NUP155 NFATC4 SETBP1 MDC1 TPX2 CCDC87	7.71e-06	430	166	11	35044719
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNB FLNC NSF HAUS5 NOL6 PSMC1 GSN RPL10A LIG3 URB1 NUP155 PTPRF AHNAK MDC1 GLUD1 AFG3L2 RPL8	8.99e-06	1024	166	17	24711643
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	FLNB CPAMD8 KIF1A TMEM8B NSD2 KIF1B SHB RNF213 DAP MGLL CERT1 KANSL3 ZNF462 PHF2 PPARGC1B SETBP1 RBM5 ZDHHC13 RAI1 PDZD2 ADSS1	9.29e-06	1489	166	21	28611215
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLNB FLNC KIF1B ANKHD1 GSN ACSL1 LIG3 AHNAK PC AHNAK2	9.93e-06	360	166	10	33111431
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	EEFSEC FLNC BMP2K RBMS1 PAK4 ANKHD1 GSN MICALL1 URB1 AHNAK MARF1 PAK2 ZNF598 AHNAK2	1.09e-05	724	166	14	36232890
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	HDAC5 STAB1 ZNF462 PHF2 URB1 ALMS1 SETBP1 WDR35	1.36e-05	225	166	8	12168954
Pubmed	Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.	FLNB FLNC PSMC1 GSN AHNAK	1.53e-05	65	166	5	34645483
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EEFSEC NOL6 ANKHD1 CEMIP2 LIG3 ARHGEF40 NUP155 AFG3L2 SLC25A10 MARF1 HLTF KMT2A CRYBG3	1.60e-05	650	166	13	38777146
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	2.26e-05	2	166	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	2.26e-05	2	166	2	28621566
Pubmed	Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes.	CBL LEP	2.26e-05	2	166	2	16494846
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	2.26e-05	2	166	2	32078638
Pubmed	Tolerance induction to self antigens by peripheral dendritic cells.	RAG1 FOXN1	2.26e-05	2	166	2	12207343
Pubmed	Transforming growth factor beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures.	ABL1 PAK2	2.26e-05	2	166	2	16867995
Pubmed	Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia.	KMT2A DOT1L	2.26e-05	2	166	2	38892207
Pubmed	Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.	TASP1 KMT2A	2.26e-05	2	166	2	14636557
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	2.26e-05	2	166	2	23595828
Pubmed	Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK.	ABL1 PAK2	2.26e-05	2	166	2	11121037
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	2.26e-05	2	166	2	21621574
Pubmed	ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A.	DEPDC1 ALPK2	2.26e-05	2	166	2	34210956
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	2.26e-05	2	166	2	28911206
Pubmed	Detection of c-Abl kinase-promoted phosphorylation of Rad51 by specific antibodies reveals that Y54 phosphorylation is dependent on that of Y315.	RAD51 ABL1	2.26e-05	2	166	2	19427856
Pubmed	The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors.	KIF1A KIF1B	2.26e-05	2	166	2	7539720
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	2.26e-05	2	166	2	22875990
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	2.26e-05	2	166	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	2.26e-05	2	166	2	15044002
Pubmed	Different immune cells mediate mechanical pain hypersensitivity in male and female mice.	RAG1 FOXN1	2.26e-05	2	166	2	26120961
Pubmed	The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.	STARD13 KIF1B	2.26e-05	2	166	2	25518808
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	2.26e-05	2	166	2	22138648
Pubmed	MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.	KMT2A DOT1L	2.26e-05	2	166	2	21741597
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	2.26e-05	2	166	2	34220417
Pubmed	A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.	FLNB FLNC	2.26e-05	2	166	2	9694715
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	2.26e-05	2	166	2	26241911
Pubmed	Genetic resistance to murine cryptococcosis: the beige mutation (Chédiak-Higashi syndrome) in mice.	FOXN1 LYST	2.26e-05	2	166	2	3965401
Pubmed	DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy.	KMT2A DOT1L	2.26e-05	2	166	2	24858818
Pubmed	c-ABL tyrosine kinase stabilizes RAD51 chromatin association.	RAD51 ABL1	2.26e-05	2	166	2	19285032
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	2.26e-05	2	166	2	21446915
Pubmed	Calcium release channel RyR2 regulates insulin release and glucose homeostasis.	LEP RYR2	2.26e-05	2	166	2	25844899
Pubmed	The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.	AHNAK AHNAK2	2.26e-05	2	166	2	15007166
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	2.26e-05	2	166	2	38060673
Pubmed	DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.	DOCK4 MUC2	2.26e-05	2	166	2	33559155
Pubmed	Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.	TASP1 KMT2A	2.26e-05	2	166	2	25267403
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	2.26e-05	2	166	2	24593767
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	2.26e-05	2	166	2	37154294
Pubmed	Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.	TASP1 KMT2A	2.26e-05	2	166	2	12393701
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	2.26e-05	2	166	2	22924626
Pubmed	[RAD51 regulates REV1 recruitment to DNA double-strand <br/>break sites].	RAD51 REV1	2.26e-05	2	166	2	30465533
Pubmed	The role of DOT1L in the maintenance of leukemia gene expression.	KMT2A DOT1L	2.26e-05	2	166	2	27151433
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	2.26e-05	2	166	2	11032875
Pubmed	Regulation of Rad51 function by c-Abl in response to DNA damage.	RAD51 ABL1	2.26e-05	2	166	2	9461559
Pubmed	Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase.	ADSS2 ADSS1	2.26e-05	2	166	2	1592113
Pubmed	Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.	LEP GIP	2.26e-05	2	166	2	18420580
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	2.26e-05	2	166	2	29943084
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	2.26e-05	2	166	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	2.26e-05	2	166	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	2.26e-05	2	166	2	27422263
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	2.26e-05	2	166	2	15750346
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	2.26e-05	2	166	2	1711373
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	2.26e-05	2	166	2	20529287
Pubmed	Molecular cloning and expression of a mouse muscle cDNA encoding adenylosuccinate synthetase.	ADSS2 ADSS1	2.26e-05	2	166	2	1939273
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	2.26e-05	2	166	2	25124006
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	2.26e-05	2	166	2	23673664
Pubmed	Tripeptidyl peptidase II promotes fat formation in a conserved fashion.	TPP2 LEP	2.26e-05	2	166	2	17932511
Pubmed	High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine.	RAG1 MUC2	2.26e-05	2	166	2	30666958
Pubmed	Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.	LEP GIP	2.26e-05	2	166	2	31509948
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	2.26e-05	2	166	2	39052831
Pubmed	An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity.	RAG1 MUC2	2.26e-05	2	166	2	21107311
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	2.26e-05	2	166	2	24442550
Pubmed	CBL mutations in infant acute lymphoblastic leukaemia.	CBL KMT2A	2.26e-05	2	166	2	21988239
Interaction	TOP3B interactions	RAD51 FLNC ABL1 PPRC1 TMEM8B NSD2 RBMS1 KIF1B TASP1 ANKHD1 TMEM127 ATP13A2 LYST CDC14A MICALL1 PPP1R26 KANSL3 NCOR1 LIG3 URB1 ARHGEF40 PTPRF ZNF592 AHNAK MDC1 DOT1L MAPKBP1 ZNF598 PC RAI1 AHNAK2	8.29e-07	1470	164	31	int:TOP3B
Interaction	NFAT5 interactions	ABL1 HDAC5 FLAD1 HLTF DOT1L	1.36e-05	38	164	5	int:NFAT5
Interaction	NUP43 interactions	RAD51 NSD2 NOL6 RYR2 KANSL3 ZNF462 PHF2 NCOR1 LIG3 ZNF592 BAZ2A MDC1 MARF1 HLTF KMT2A AHNAK2 PDZD2	1.42e-05	625	164	17	int:NUP43
Interaction	KCNA3 interactions	FLNB ANK2 NSF KIF1B PAK4 SHB PSMC1 RNF213 MICALL1 RPL10A NUP155 ADSS2 AHNAK AFG3L2 PAK2 KMT2A CRYBG3 SEPTIN7 PLS3 RPL8	2.83e-05	871	164	20	int:KCNA3
Coexpression	GSE17301_ACD3_ACD28_VS_ACD3_ACD28_AND_IFNA5_STIM_CD8_TCELL_UP	RAG1 HAUS5 HMGB2 DEPDC1 KANSL3 SETBP1 SLC25A10 TPX2 FADS2 PC	5.45e-07	198	165	10	M8041
Coexpression	GSE17186_BLOOD_VS_CORD_BLOOD_CD21LOW_TRANSITIONAL_BCELL_DN	ABL1 ACVR2A CDC14A LIPA FBXO6 ALMS1 SLC25A10 CRYBG3 PLS3 ADSS1	5.98e-07	200	165	10	M7196
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	DOCK4 TPP2 FLNB HDAC5 TMEM8B NSD2 RBMS1 INPP5K KIF1B SHB MGLL ANKHD1 CERT1 ATP13A2 COQ10A NCOR1 FBXO6 ALMS1 SLC25A10 MARF1 WDR35 RBM5	1.75e-06	1102	165	22	M2369
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	DOCK4 TPP2 FLNB HDAC5 TMEM8B NSD2 RBMS1 INPP5K KIF1B SHB MGLL ANKHD1 CERT1 ATP13A2 COQ10A NCOR1 FBXO6 ALMS1 SLC25A10 MARF1 WDR35 RBM5	2.41e-06	1124	165	22	MM1070
Coexpression	GSE19941_IL10_KO_VS_IL10_KO_AND_NFKBP50_KO_LPS_AND_IL10_STIM_MACROPHAGE_UP	TMEM176B KIF1A BMP2K ACVR2A STAB1 NCOR1 PAK2 PIK3R5	3.98e-05	199	165	8	M8115
Coexpression	GSE24142_DN2_VS_DN3_THYMOCYTE_ADULT_DN	TPP2 RAG1 CBL LYST PPARGC1B PTPRF GZMA REV1	3.98e-05	199	165	8	M4567
Coexpression	GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_2H_DN	KIF1B PSMC1 RNF13 MGLL CEMIP2 KANSL3 MDC1 PIK3R5	4.12e-05	200	165	8	M6127
Coexpression	GSE17721_POLYIC_VS_GARDIQUIMOD_1H_BMDC_UP	TMEM176B KIF1A BMP2K KIF1B ATP13A2 KMT2A MAPK8IP2 REV1	4.12e-05	200	165	8	M4016
Coexpression	GSE25123_ROSIGLITAZONE_VS_IL4_AND_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_DAY10_DN	SPATA6L TMEM8B INPP5K ATP13A2 LYST RBM5 RAI2 RAI1	4.12e-05	200	165	8	M7992
Coexpression	GSE7831_UNSTIM_VS_CPG_STIM_PDC_4H_DN	FLNB DAP LYST RYR2 GSN HLTF PLS3 RAI2	4.12e-05	200	165	8	M6954
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_INTERM_NEUROENDOCRINE_CELL	TMEM176B ANK2 KIF1A TACC2 LYST ACSL1 ST6GALNAC5 SETBP1 MAPK8IP2	5.34e-05	268	165	9	M45696
Coexpression	RODRIGUES_NTN1_TARGETS_DN	FLNB SHB RNF213 CBL AHNAK RBM5 PRLR	7.46e-05	161	165	7	M11857
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	STARD13 DOCK4 BMP2K RNF13 CR1 STAB1 ACSL1 FMN1 PIK3R5	5.01e-08	195	165	9	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	STARD13 DOCK4 TMEM176B BMP2K CR1 STAB1 ACSL1 FMN1 PIK3R5	5.47e-08	197	165	9	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	STARD13 DOCK4 TMEM176B BMP2K CR1 STAB1 ACSL1 FMN1 PIK3R5	5.47e-08	197	165	9	304044ace926943b8eb588f686ecbe5d1689a809
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMEM176B BMP2K CR1 STAB1 ACSL1 PPARGC1B LIPA FMN1 PIK3R5	6.23e-08	200	165	9	78d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 DOCK4 ZNF366 GSN STAB1 ACSL1 FMN1 PIK3R5	6.92e-07	195	165	8	247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DGKB FMN1 ST6GALNAC5 SETBP1 TMEM150C MUC2 ALPK2	1.77e-06	154	165	7	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2K PPRC1 HAUS5 URB1 NUP155 MDC1 DOT1L	2.10e-06	158	165	7	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP24A1 DGKB PPARGC1B PC PRLR ALPK2 PDZD2	4.30e-06	176	165	7	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB FMO4 MGLL TRUB1 CEMIP2 STAB1 FADS2	5.16e-06	181	165	7	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK4 CERT1 LYST CDC14A CEMIP2 STAB1 ZNF462	6.86e-06	189	165	7	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK4 CERT1 LYST CDC14A CEMIP2 STAB1 ZNF462	6.86e-06	189	165	7	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	ANK2 TACC2 RYR2 PPARGC1B MYLK3 ALPK2 PDZD2	6.86e-06	189	165	7	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	COVID-19-Heart-Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STARD13 BMP2K CR1 STAB1 ACSL1 FMN1 PIK3R5	6.86e-06	189	165	7	2586f4088721c5debec86c2b211b739fd33713eb
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TMEM176B BMP2K CR1 STAB1 ACSL1 FMN1 PIK3R5	7.34e-06	191	165	7	24d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPL10A ZNF750 PTPRF FEZF1 SLC25A10 ZDHHC13 RPL8	7.34e-06	191	165	7	49068e3b7d265d4767d7b3c79d455dbc2fd8c6cd
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSF NSD2 CERT1 CDC14A CEMIP2 STAB1 PTPRF	7.60e-06	192	165	7	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMP2K CR1 CEMIP2 STAB1 ACSL1 FMN1 PIK3R5	7.86e-06	193	165	7	bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCell	facs-Tongue-nan-3m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXN1 BMP2K LPCAT4 GSN ACSL1 ZNF750 ZDHHC13	7.86e-06	193	165	7	33437fdb417d78463caee14a9f0e094da1733829
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ANK2 KIF1A KIF1B PTPRF PC PRLR	7.86e-06	193	165	7	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ANK2 KIF1A KIF1B PTPRF PC PRLR	7.86e-06	193	165	7	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMP2K CR1 CEMIP2 STAB1 ACSL1 FMN1 PIK3R5	7.86e-06	193	165	7	374d0526a071e973c3f43b4564f78f6933bb67ed
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMP2K CR1 CEMIP2 STAB1 ACSL1 FMN1 PIK3R5	8.13e-06	194	165	7	96f16bcd393a0d3f8df479b172b5360ae5a1e663
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 KIF1A KIF1B NCOR1 PTPRF PC PRLR	8.13e-06	194	165	7	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 DOCK4 GSN STAB1 ACSL1 FMN1 PIK3R5	8.13e-06	194	165	7	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	DOCK4 CR1 CEMIP2 STAB1 ACSL1 FMN1 PIK3R5	8.13e-06	194	165	7	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMP2K CR1 CEMIP2 STAB1 ACSL1 FMN1 PIK3R5	8.41e-06	195	165	7	91a3c439f10c03c5d51d904f512b6a08040edc76
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1A KIF1B NCOR1 PTPRF KMT2A PC MAPK8IP2	8.41e-06	195	165	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TMEM176B BMP2K CR1 STAB1 ACSL1 FMN1 PIK3R5	8.41e-06	195	165	7	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	COVID-19-Myeloid\|COVID-19 / group, cell type (main and fine annotations)	DOCK4 BMP2K RNF13 STAB1 ACSL1 FMN1 PIK3R5	9.28e-06	198	165	7	33f0a919188a67d2a876b52c61a1cec2c9747969
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ASIC5 CR1 LEP PPARGC1B LIPA FMN1 PIK3R5	9.28e-06	198	165	7	0b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell	COPD-Myeloid-Macrophage\|COPD / Disease state, Lineage and Cell class	STARD13 DOCK4 TMEM176B STAB1 ACSL1 FMN1 PIK3R5	9.59e-06	199	165	7	4b9c53fb4f44190d2f6ad4d52b13be01ebe4955e
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK4 RNF213 CEMIP2 STAB1 FMN1 ST6GALNAC5 PIK3R5	9.59e-06	199	165	7	155b03b859157013e9142e9248551369127d9204
ToppCell	Parenchyma_COVID-19-Immune-TX-MoAM-2\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	TMEM176B BMP2K RNF13 CR1 STAB1 ACSL1 LIPA	9.91e-06	200	165	7	33c5615cbedb9e14f4433169babd3a3a51f69b4c
ToppCell	MS-CD4-CD8_1\|MS / Condition, Cell_class and T cell subcluster	EEFSEC ABL1 DEPDC1 MYLK3 GZMA PDZD2	2.05e-05	150	165	6	7dc95c58b98d8c4c6c49fb1a03ec6ac24fb41f54
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EEFSEC NOL6 TASP1 GSN NFATC4 TMEM150C	2.56e-05	156	165	6	895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	RAD51 RAG1 SPATA6L DEPDC1 SLC25A10 TPX2	3.51e-05	165	165	6	a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 CR1 STAB1 ACSL1 FMN1 PIK3R5	3.88e-05	168	165	6	61a5435b27b01ff1a509ea463a6af220c5d2c9b3
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 CR1 STAB1 ACSL1 FMN1 PIK3R5	3.88e-05	168	165	6	26fce414439ccd204e3acb41f2b4f75072df5a26
ToppCell	COVID-19_Mild-PLT_2\|World / Disease Group and Platelet Clusters	ABL1 HAUS5 NOL6 TRUB1 LIG3 SLCO4C1	4.01e-05	169	165	6	6abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCell	(7)_MNP-(7)_DC_activated\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	BMP2K ZNF366 MGLL PTPRF TMEM150C ALPK2	4.15e-05	170	165	6	4ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLNC ANK2 RYR2 MYLK3 FMN1 ALPK2	4.15e-05	170	165	6	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	NS-critical-d_0-4-Lymphoid-B_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NSD2 TASP1 URB1 NUP155 MDC1 MCEE	4.28e-05	171	165	6	bd1ebd9037a740ad8c01c460d778b0973d8b56df
ToppCell	metastatic_Brain-Fibroblasts-Undetermined\|Fibroblasts / Location, Cell class and cell subclass	RAD51 DOCK4 CPAMD8 FMN1 FADS2 AHNAK2	4.43e-05	172	165	6	c3822ff7329c3ac38c68c5c38cd67c390682e2a6
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK4 ATP13A2 PTPRF AHNAK SETBP1 CCR4	4.43e-05	172	165	6	2a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-migDC\|lymph-node_spleen / Manually curated celltypes from each tissue	CFAP47 TMEM176B BMP2K ZNF366 MGLL TMEM150C	4.43e-05	172	165	6	1b24bed3cd8e3fa463c5e7cefdf9e99e639e2f84
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK4 ATP13A2 PTPRF AHNAK SETBP1 CCR4	4.43e-05	172	165	6	7fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCell	COVID-19_Mild-PLT_2\|COVID-19_Mild / Disease Group and Platelet Clusters	ABL1 HAUS5 NOL6 TRUB1 LIG3 SLCO4C1	4.57e-05	173	165	6	d11705e56b6b21eec963ea224717f27680c781ed
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAD51 NSD2 HAUS5 HMGB2 DEPDC1 TPX2	5.19e-05	177	165	6	8a74f5e72de605774111057bd87a7e7e4a6385cd
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	KIF1A PPP1R26 VPS13D MARF1 KMT2A PC	5.19e-05	177	165	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRUB1 SLC44A4 H1-8 ARHGEF40 FMN1 NKAPL	5.19e-05	177	165	6	4a697866ed542d3201714234cee03451adf1dcc9
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ZNF366 CR1 ZNF469 ST6GALNAC5 PIK3R5 ALPK2	5.52e-05	179	165	6	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	control-Lymphoid-NKT-proliferating\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RAD51 HMGB2 DEPDC1 RPL10A TPX2 RPL8	5.70e-05	180	165	6	535535a67b3f3320bad2f98b1bc98a7b0ee77840
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	STARD13 TMEM176B DEPDC1 GSN STAB1 TPX2	5.70e-05	180	165	6	4eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR2 COQ10A SPATA33 MYLK3 ALPK2 ADSS1	5.88e-05	181	165	6	09a574a3257e25c8b05a2ab20623a6b07331411a
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR2 COQ10A SPATA33 MYLK3 ALPK2 ADSS1	5.88e-05	181	165	6	ac4142aa93706b7067f63d2d38e2456859e60768
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-migDC\|lymph-node_spleen / Manually curated celltypes from each tissue	TMEM176B ZNF366 MGLL GSN PTPRF TMEM150C	5.88e-05	181	165	6	94680f8dbdf22d83801abc0819417751d363fb12
ToppCell	NS-control-d_0-4-Lymphoid-NKT-proliferating\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RAD51 HMGB2 DEPDC1 RPL10A TPX2 RPL8	6.06e-05	182	165	6	f623c47e7806181d09f126066a952162ce49a306
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 TACC2 GSN ST6GALNAC5 CCR4 SEPTIN7	6.24e-05	183	165	6	a0a3e4d07ac73dbbb1e019fd11e88ccffe6cf2ca
ToppCell	droplet-Thymus-nan-18m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B MGLL ACVR2A C7orf57 PRLR ALPK2	6.24e-05	183	165	6	ffb1bbbccb34d1a7e99872611f497450039d5019
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B CEMIP2 STAB1 ZCCHC4 H1-8 RAI2	6.24e-05	183	165	6	b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B CDC14A CEMIP2 STAB1 MICALL1 RAI2	6.24e-05	183	165	6	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP24A1 ACSL1 LIPA SLC25A10 PC PRLR	6.44e-05	184	165	6	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	(7)_DC_activated\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	TMEM176B ZNF366 MGLL GSN TMEM150C ALPK2	6.44e-05	184	165	6	b89871a3e36fde6daa68daf116f8c8d587554c0f
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RAD51 TMEM176B HMGB2 GSN STAB1 ACSL1	6.44e-05	184	165	6	97ae5ffecf90df42cc8eea2a247ca589f35a4783
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLNC ANK2 TACC2 RYR2 MYLK3 ALPK2	6.63e-05	185	165	6	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DGKB PPARGC1B PC PRLR ALPK2 PDZD2	6.83e-05	186	165	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MGLL CR1 STAB1 ACSL1 FMN1 PIK3R5	7.46e-05	189	165	6	440c422369de1c49112d18cf8c506a2a3a81f6ba
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B CDC14A CEMIP2 STAB1 MICALL1 RAI2	7.68e-05	190	165	6	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	normal_Lymph_Node-Myeloid_cells-Activated_DCs\|normal_Lymph_Node / Location, Cell class and cell subclass	TMEM176B BMP2K ZNF366 MGLL GSN TMEM150C	7.68e-05	190	165	6	15978ddd37b521343f88b62dad1643077fc22b2b
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STARD13 TMEM176B BMP2K CR1 STAB1 FMN1	7.68e-05	190	165	6	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STARD13 BMP2K KIF1B STAB1 FMN1 PIK3R5	7.68e-05	190	165	6	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FLNB ANK2 KIF1A ACSL1 ST6GALNAC5 MAPK8IP2	7.68e-05	190	165	6	5f1863bce9400b7c932f0e4d0e012ec4e8d7e555
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK4 MGLL PTPRF ST6GALNAC5 PLS3 PDZD2	7.68e-05	190	165	6	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	ANK2 TACC2 RYR2 MYLK3 ALPK2 PDZD2	7.68e-05	190	165	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM176B RPL10A HSPA12A LIPA ST6GALNAC5 PLS3	7.91e-05	191	165	6	89d03c4133dda852a3713c0902a7d67941cf5b21
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	NSD2 HMGB2 NCOR1 RBM5 KMT2A AHNAK2	8.14e-05	192	165	6	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	TMEM176B ZNF366 MGLL LYST PTPRF TMEM150C	8.14e-05	192	165	6	e44e37e5aeba8628556020d05e1606b28e2faa4f
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	STARD13 DOCK4 LEP STAB1 ARHGEF40 FMN1	8.14e-05	192	165	6	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	Control-Myeloid-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	BMP2K CR1 STAB1 ACSL1 FMN1 PIK3R5	8.37e-05	193	165	6	a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCell	facs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB DAP ATP13A2 GSN SUCO PLS3	8.37e-05	193	165	6	eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TACC2 SLC44A4 ZNF750 EYS PTPRF NFATC4	8.37e-05	193	165	6	44839a606ae2f8e37421bda46d588189e1c943d2
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TMEM176B LYST CEMIP2 STAB1 ACSL1 AHNAK	8.37e-05	193	165	6	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	STARD13 BMP2K CR1 STAB1 FMN1 PIK3R5	8.37e-05	193	165	6	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	Immune-interstitial_macrophage_(C1Q_positive)\|World / Lineage, Cell type, age group and donor	TMEM176B BMP2K CR1 STAB1 FMN1 PIK3R5	8.37e-05	193	165	6	64d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1A KIF1B NCOR1 PTPRF PC PRLR	8.62e-05	194	165	6	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TMEM176B LYST CEMIP2 STAB1 ACSL1 AHNAK	8.62e-05	194	165	6	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	ANK2 TACC2 RYR2 MYLK3 ALPK2 PDZD2	8.62e-05	194	165	6	c3535f7cc0076653c72db582047cff053c322397
ToppCell	CTRL-Myeloid-Monocyte_Macrophage\|CTRL / Disease state, Lineage and Cell class	STARD13 DOCK4 TMEM176B STAB1 FMN1 PRLR	8.62e-05	194	165	6	927480f56cccd3940b689f3c40ee132fe3e63745
ToppCell	facs-Skin-Anagen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB DAP ATP13A2 GSN SUCO PLS3	8.62e-05	194	165	6	5d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	STARD13 DOCK4 TMEM176B ACSL1 FMN1 PIK3R5	8.62e-05	194	165	6	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RAD51 NSD2 HMGB2 DEPDC1 GZMA TPX2	8.62e-05	194	165	6	6cc689595a182fbf685fa2f3b9c300f7170fb81f
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STARD13 BMP2K STAB1 ACSL1 FMN1 PIK3R5	8.62e-05	194	165	6	663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK4 TMEM176B BMP2K CEMIP2 STAB1 ACSL1	8.62e-05	194	165	6	449ce4167d64c170d914e0250f739eabedcf915d
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	BMP2K CR1 STAB1 ACSL1 FMN1 PIK3R5	8.86e-05	195	165	6	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	LA-08._Macrophage\|LA / Chamber and Cluster_Paper	CR1 CEMIP2 STAB1 ACSL1 FMN1 PIK3R5	8.86e-05	195	165	6	5e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB MICALL1 RPL10A ZNF750 PTPRF RPL8	8.86e-05	195	165	6	dde7a4e84f476d0cf8df240dae6290220c9cdcc9
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1A KIF1B NCOR1 PTPRF KMT2A PC	8.86e-05	195	165	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Monocytes-M2-like_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	STARD13 DOCK4 TMEM176B GSN STAB1 ARHGEF40	8.86e-05	195	165	6	10fa47bdcf6c9784ea930b75a5861e139421feed
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	RNF13 CBL STAB1 ACSL1 FMN1 PIK3R5	9.11e-05	196	165	6	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	Control-Myeloid-Macrophage\|Control / Disease state, Lineage and Cell class	DOCK4 TMEM176B STAB1 ACSL1 FMN1 PIK3R5	9.11e-05	196	165	6	e2c2a30fa3ee3034fbde5335be169e880dde622d
Drug	phosphohydantocidin	ADSS2 SEPTIN7 ADSS1	3.74e-07	3	165	3	CID000446561
Drug	C16:1n-7	LEP ACSL1 NUTM1 PPARGC1B FLAD1 FADS2	4.34e-06	59	165	6	CID000004668
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; MCF7; HT_HG-U133A	FMO4 TMEM8B CR1 CBL GSN ZNF750 URB1 RBM5 MASP2	1.11e-05	191	165	9	2824_UP
Drug	2-oxoglutaconic acid	NSF GLUD1 GLUD2	1.28e-05	7	165	3	CID006443759
Drug	Phentolamine hydrochloride [73-05-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A	RAD51 FLNC CDC14A GSN ZCCHC4 RBM5 FADS2 KMT2A RBM34	1.31e-05	195	165	9	3860_UP
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A	FMO4 HDAC5 CBL CDC14A MICALL1 HSPA12A VPS13D FADS2 SGSM3	1.54e-05	199	165	9	5570_DN
Drug	Neomycin sulfate [1405-10-3]; Up 200; 4.2uM; HL60; HG-U133A	FLNB HDAC5 CBL CERT1 NAA35 VPS13D ARHGEF40 BAZ2A PRDM13	1.54e-05	199	165	9	1383_UP
Drug	Dipyrone [5907-38-0]; Down 200; 12uM; HL60; HT_HG-U133A	FMO4 BMP2K PAK4 HAUS5 CDC14A MICALL1 URB1 ZNF592 SGSM3	1.60e-05	200	165	9	2175_DN
Drug	6-chloroquinoxaline-2,3-diol	GRIN2A GLUD1 GLUD2	2.04e-05	8	165	3	CID000081143
Drug	AC1MQ2IK	ACSL1 GLUD1 GLUD2	2.04e-05	8	165	3	CID003394958
Drug	AC1LCV0Y	ACSL1 GLUD1 GLUD2 FADS2	3.51e-05	26	165	4	CID000656469
Drug	AC1NSUIJ	CYP24A1 NCOR1 GLUD1	4.32e-05	10	165	3	CID005316686
Drug	phenyltriethoxysilane	GLUD1 GLUD2	5.22e-05	2	165	2	CID000013075
Drug	AC1LAPI9	ADSS2 ADSS1	5.22e-05	2	165	2	CID000472615
Drug	G-3SH	GLUD1 GLUD2	5.22e-05	2	165	2	CID000174237
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	5.22e-05	2	165	2	CID006455327
Drug	methylmercuric bromide	GLUD1 GLUD2	5.22e-05	2	165	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	5.22e-05	2	165	2	CID000068137
Drug	x 1 s	GLUD1 GLUD2	5.22e-05	2	165	2	CID000409694
Drug	p-hydroxyphenylpyruvate	GIP ADSS2 GLUD1 GLUD2 PLS3 ADSS1	5.30e-05	91	165	6	CID000000979
Drug	wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A	STARD13 HDAC5 INPP5K AHNAK MARF1 FADS2 TSTD2 PRLR	5.86e-05	183	165	8	1668_UP
Drug	magnesium	RAD51 EEFSEC RAG1 CPAMD8 KIF1A NSF PAK4 TASP1 DGKB MGLL GRIN2A TRUB1 CBL RYR2 GSN LIG3 ADSS2 FLAD1 PC ZDHHC13 PLS3 RPL8 ADSS1	8.86e-05	1325	165	23	CID000000888
Drug	Mexiletine hydrochloride [5370-01-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	LYST GSN VPS13D RBM5 FADS2 KMT2A PRLR RAI2	9.14e-05	195	165	8	3862_UP
Drug	Glycopyrrolate [596-51-0]; Up 200; 10uM; MCF7; HT_HG-U133A	DOCK4 HDAC5 BMP2K INPP5K LIG3 BAZ2A SGSM3 PRLR	9.14e-05	195	165	8	3427_UP
Drug	Benzylpenicillin sodium [69-57-8]; Down 200; 11.2uM; HL60; HT_HG-U133A	KIF1B PAK4 CR1 GSN ALMS1 FADS2 MAPKBP1 ZDHHC13	9.47e-05	196	165	8	6155_DN
Drug	SC-58125; Down 200; 10uM; SKMEL5; HG-U133A	TOB2 NSD2 TMEM127 ATP13A2 MICALL1 LIG3 VPS13D MAPKBP1	9.47e-05	196	165	8	507_DN
Drug	Deferoxamine mesylate [138-14-7]; Down 200; 6uM; MCF7; HT_HG-U133A	RAD51 BMP2K LPCAT4 MICALL1 ZNF750 KMT2A MAPKBP1 MAPK8IP2	9.47e-05	196	165	8	3936_DN
Drug	Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A	TMEM176B DGKB CBL KANSL3 NCOR1 SGSM3 RAI1 MASP2	9.81e-05	197	165	8	6779_UP
Drug	Tetrahydroxy-1,4-quinone monohydrate [319-89-1]; Down 200; 21uM; MCF7; HT_HG-U133A	STARD13 BMP2K INPP5K HAUS5 PTPRF BAZ2A KMT2A PC	9.81e-05	197	165	8	3338_DN
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CR1 LYST KANSL3 ZNF750 RBM5 KMT2A PRLR RBM34	9.81e-05	197	165	8	3859_UP
Drug	Anabasine [494-52-0]; Up 200; 24.6uM; HL60; HT_HG-U133A	STARD13 SHB PPP1R26 ZCCHC4 LIG3 NFATC4 AHNAK KMT2A	9.81e-05	197	165	8	2512_UP
Drug	Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	HAUS5 CDC14A RYR2 NCOR1 HSPA12A VPS13D PC AHNAK2	9.81e-05	197	165	8	3308_DN
Drug	Azacyclonol [115-46-8]; Down 200; 15uM; HL60; HG-U133A	TOB2 CERT1 URB1 ARHGEF40 BAZ2A FADS2 KMT2A MAPKBP1	1.02e-04	198	165	8	2020_DN
Drug	Flucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; PC3; HT_HG-U133A	RAD51 NSD2 KANSL3 URB1 KMT2A PIK3R5 RAI2 MASP2	1.02e-04	198	165	8	5102_UP
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A	STARD13 CBL CDC14A PHOX2A RBM5 SEPTIN7 PRLR AHNAK2	1.02e-04	198	165	8	6053_DN
Drug	Glafenine hydrochloride [65513-72-6]; Up 200; 9.8uM; MCF7; HT_HG-U133A	HAUS5 TACC2 CBL ATP13A2 VPS13D PTPRF RBM5 SGSM3	1.02e-04	198	165	8	7018_UP
Drug	Pipemidic acid [51940-44-4]; Up 200; 13.2uM; HL60; HT_HG-U133A	STARD13 TMEM176B LPCAT4 CBL RYR2 STAB1 URB1 CCR4	1.02e-04	198	165	8	3093_UP
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; MCF7; HT_HG-U133A	HDAC5 URB1 VPS13D BAZ2A RBM5 MAPK8IP2 MASP2 AHNAK2	1.05e-04	199	165	8	3287_UP
Drug	Vinpocetine [42971-09-5]; Down 200; 11.4uM; PC3; HT_HG-U133A	BMP2K LYST GSN VPS13D ALMS1 ZNF592 BAZ2A TSTD2	1.05e-04	199	165	8	5859_DN
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	DOCK4 RAG1 CYP24A1 CDC14A CCDC87 PRLR MAPK8IP2 RAI2	1.05e-04	199	165	8	3566_UP
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A	RAD51 ZCCHC4 PHOX2A HSPA12A VPS13D SETBP1 SEPTIN7 MUC2	1.05e-04	199	165	8	4774_UP
Drug	Crotamiton [483-63-6]; Up 200; 19.6uM; PC3; HT_HG-U133A	TMEM8B CDC14A KANSL3 ZCCHC4 LIG3 CCDC87 HBE1 MASP2	1.05e-04	199	165	8	4628_UP
Drug	Hydrocotarnine hydrobromide [5985-00-2]; Down 200; 13.2uM; PC3; HT_HG-U133A	TMEM8B INPP5K CDC14A LIG3 ZNF592 BAZ2A SETBP1 SGSM3	1.09e-04	200	165	8	4489_DN
Drug	Meclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A	TPP2 CDC14A LIG3 HSPA12A BAZ2A SGSM3 MAPKBP1 PRLR	1.09e-04	200	165	8	3405_DN
Drug	chloramine-T	SHB HMGB2 ASIC5 LEP PRLR RAI2	1.24e-04	106	165	6	CID000031388
Drug	7,8-diaminopelargonic acid	NCOR1 ADSS2 ADSS1	1.28e-04	14	165	3	CID000000652
Disease	Parkinson's disease (implicated_via_orthology)	BMP2K NSF PPRC1 PAK4 PSMC1 ATP13A2 LEP PPARGC1B	2.53e-06	157	161	8	DOID:14330 (implicated_via_orthology)
Disease	Manic	HDAC5 GRIN2A STAB1 ZNF592 FADS2 PC	4.46e-06	78	161	6	C0338831
Disease	bipolar I disorder	TDRD15 HDAC5 GRIN2A ANKHD1 ZNF592 FADS2 PC	1.29e-05	141	161	7	EFO_0009963
Disease	Osteoporosis	HDAC5 CYP24A1 MGLL GSN ZDHHC13	2.47e-05	63	161	5	C0029456
Disease	metabolite measurement, diet measurement	SLC44A4 NCOR1 AHNAK FADS2 NKAPL	4.42e-05	71	161	5	EFO_0004725, EFO_0008111
Disease	Manic Disorder	HDAC5 GRIN2A ZNF592 FADS2 PC	4.42e-05	71	161	5	C0024713
Disease	Depression, Bipolar	HDAC5 GRIN2A ZNF592 FADS2 PC	7.39e-05	79	161	5	C0005587
Disease	myofibrillar myopathy 5 (implicated_via_orthology)	FLNB FLNC	8.84e-05	3	161	2	DOID:0080096 (implicated_via_orthology)
Disease	distal muscular dystrophy 4 (implicated_via_orthology)	FLNB FLNC	8.84e-05	3	161	2	DOID:0111190 (implicated_via_orthology)
Disease	sarcoma (biomarker_via_orthology)	ADSS2 ADSS1	8.84e-05	3	161	2	DOID:1115 (biomarker_via_orthology)
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	8.84e-05	3	161	2	DOID:885 (biomarker_via_orthology)
Disease	cortical thickness	FLNB CPAMD8 NSF TACC2 ATP13A2 STAB1 MICALL1 ZNF462 GIP ZNF469 VPS13D ARHGEF40 PTPRF TPX2 FADS2 KMT2A PDZD2	1.31e-04	1113	161	17	EFO_0004840
Disease	Neurodevelopmental Disorders	ANK2 CERT1 PHF2 SETBP1 KMT2A	1.60e-04	93	161	5	C1535926
Disease	synucleinopathy (biomarker_via_orthology)	KIF1A KIF1B	1.76e-04	4	161	2	DOID:0050890 (biomarker_via_orthology)
Disease	facial pigmentation measurement	SPATA33 PPARGC1B LIPA FMN1	2.69e-04	57	161	4	EFO_0006942
Disease	Malignant neoplasm of breast	RAD51 FLNB ABL1 ANK2 ZNF366 NSD2 INPP5K CYP24A1 TACC2 LEP GSN MICALL1 NCOR1 PPARGC1B SETBP1 PLS3	2.75e-04	1074	161	16	C0006142
Disease	Myelomonocytic leukemia	CBL SETBP1	2.93e-04	5	161	2	C0027019
Disease	Post-Traumatic Osteoporosis	CYP24A1 MGLL GSN ZDHHC13	3.50e-04	61	161	4	C0751406
Disease	Osteoporosis, Senile	CYP24A1 MGLL GSN ZDHHC13	3.50e-04	61	161	4	C0029459
Disease	Osteoporosis, Age-Related	CYP24A1 MGLL GSN ZDHHC13	3.50e-04	61	161	4	C0001787
Disease	forced expiratory volume	EEFSEC BMP2K RBMS1 TASP1 DGKB GRIN2A SLC44A4 RYR2 NCOR1 EYS NFATC4 AHNAK PC	4.11e-04	789	161	13	EFO_0004314
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	4.37e-04	6	161	2	DOID:1825 (biomarker_via_orthology)
Disease	Failure to Thrive	ABL1 RNF13	4.37e-04	6	161	2	C0015544
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	NOL6 RNF13 TACC2 GRIN2A RYR2 CEMIP2 PHOX2A HSPA12A ALMS1 PTPRF KIF2B FEZF1 SETBP1	4.73e-04	801	161	13	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	Colorectal Carcinoma	FLNC CPAMD8 ANK2 GRIN2A SLC44A4 CDC14A LIG3 MYLK3 SETBP1 TPX2 FADS2 PIK3R5	4.97e-04	702	161	12	C0009402
Disease	blood sedimentation	CR1 HBE1	6.10e-04	7	161	2	EFO_0004304
Disease	temporal lobe epilepsy (biomarker_via_orthology)	NSF GLUD1 GLUD2	6.41e-04	31	161	3	DOID:3328 (biomarker_via_orthology)
Disease	severe acute respiratory syndrome, COVID-19	DGKB LYST MICALL1 ZCCHC4 PHOX2A HSPA12A EYS ADSS2 PDZD2	8.16e-04	447	161	9	EFO_0000694, MONDO_0100096
Disease	Burkitt Lymphoma	ABL1 KMT2A PC	9.97e-04	36	161	3	C0006413
Disease	colon cancer (is_implicated_in)	CYP24A1 ACVR2A PIK3R5	9.97e-04	36	161	3	DOID:219 (is_implicated_in)
Disease	response to bevacizumab, hypertension, Proteinuria	GRIN2A EVX2	1.04e-03	9	161	2	EFO_0000537, EFO_0005943, HP_0000093
Disease	level of Phosphatidylcholine (16:0_20:5) in blood serum	AHNAK FADS2	1.04e-03	9	161	2	OBA_2045077
Disease	level of Phosphatidylcholine (18:0_20:5) in blood serum	AHNAK FADS2	1.04e-03	9	161	2	OBA_2045095
Disease	sexual dimorphism measurement	HDAC5 KIF1A GRIN2A CERT1 ATP13A2 RPL10A ZNF462 ARHGEF40 ZNF592 NFATC4 FADS2 DOT1L MAPKBP1 PC SUCO	1.11e-03	1106	161	15	EFO_0021796
Disease	cortical surface area measurement	FLNB CPAMD8 NSF TMEM8B KIF1B ACVR2A CERT1 ATP13A2 NCOR1 ZNF469 PTPRF MDC1 FADS2 CCR4 PC PRLR PDZD2	1.13e-03	1345	161	17	EFO_0010736
Disease	Amyloidosis	GSN ZDHHC13	1.29e-03	10	161	2	C0002726
Disease	VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)	ANK2 RYR2	1.29e-03	10	161	2	C1631597
Disease	hematocrit	STARD13 TDRD15 KIF1B CR1 GSN STAB1 ZNF462 SPATA33 ARHGEF40 FMN1 FADS2 DOT1L HBE1 RAI1	1.34e-03	1011	161	14	EFO_0004348
Disease	alkaline phosphatase measurement	TDRD15 TMEM176B ZNF366 CYP24A1 GSN GIP ZCCHC4 SPATA33 LIPA NFATC4 AHNAK FADS2 ALPK2 RAI1	1.39e-03	1015	161	14	EFO_0004533
Disease	descending aortic diameter	FLNB ARHGEF40 NFATC4 DOT1L	1.39e-03	88	161	4	EFO_0021788
Disease	Semantic-Pragmatic Disorder	GRIN2A SETBP1	1.58e-03	11	161	2	C0454655
Disease	Auditory Processing Disorder, Central	GRIN2A SETBP1	1.58e-03	11	161	2	C0751257
Disease	Language Delay	GRIN2A SETBP1	1.58e-03	11	161	2	C0023012
Disease	Language Development Disorders	GRIN2A SETBP1	1.58e-03	11	161	2	C0023014
Disease	quality of life during menstruation measurement, dysmenorrheic pain measurement	MGLL GRIN2A	1.58e-03	11	161	2	EFO_0007889, EFO_0009366
Disease	Speech Delay	GRIN2A SETBP1	1.58e-03	11	161	2	C0241210
Disease	concentration of large LDL particles measurement	TDRD15 CERT1 FADS2	1.79e-03	44	161	3	EFO_0022160
Disease	metabolite measurement, body weight gain	TACC2 FADS2	1.88e-03	12	161	2	EFO_0004566, EFO_0004725
Disease	hyperinsulinism (is_implicated_in)	PTPRF GLUD1	1.88e-03	12	161	2	DOID:2018 (is_implicated_in)
Disease	nervous system disease (implicated_via_orthology)	KIF1A KIF1B	1.88e-03	12	161	2	DOID:863 (implicated_via_orthology)
Disease	linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] measurement	FADS2 PDZD2	1.88e-03	12	161	2	EFO_0800500
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	TDRD15 SLC44A4 CERT1 FADS2	2.15e-03	99	161	4	EFO_0004611, EFO_0007878
Disease	FVC change measurement, response to placebo	KIF1A DGKB	2.22e-03	13	161	2	EFO_0008344, EFO_0010339
Disease	basophil percentage of leukocytes	EEFSEC DAP ACVR2A C7orf57 LYST ZNF469	2.24e-03	243	161	6	EFO_0007992
Disease	obesity (is_marker_for)	LEP ACSL1 GIP PTPRF	2.31e-03	101	161	4	DOID:9970 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	TDRD15 SLC44A4 CERT1 FADS2	2.40e-03	102	161	4	EFO_0004329, EFO_0004611
Disease	Weight Gain	LEP GSN VPS13D SETBP1	2.40e-03	102	161	4	C0043094
Disease	Mammary Carcinoma, Human	RAD51 ABL1 ZNF366 NSD2 CYP24A1 LEP NCOR1 PPARGC1B SETBP1	2.46e-03	525	161	9	C4704874
Disease	Mammary Neoplasms, Human	RAD51 ABL1 ZNF366 NSD2 CYP24A1 LEP NCOR1 PPARGC1B SETBP1	2.46e-03	525	161	9	C1257931
Disease	Mammary Neoplasms	RAD51 ABL1 ZNF366 NSD2 CYP24A1 LEP NCOR1 PPARGC1B SETBP1	2.52e-03	527	161	9	C1458155
Disease	L2 Acute Lymphoblastic Leukemia	ABL1 NSD2 KMT2A	2.59e-03	50	161	3	C0023453
Disease	type 2 diabetes mellitus (implicated_via_orthology)	LEP GIP PHOX2A ALMS1	2.66e-03	105	161	4	DOID:9352 (implicated_via_orthology)
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	TDRD15 CERT1 FADS2	2.74e-03	51	161	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	Breast Carcinoma	RAD51 ABL1 ZNF366 NSD2 CYP24A1 LEP NCOR1 PPARGC1B SETBP1	2.89e-03	538	161	9	C0678222
Disease	Childhood Acute Lymphoblastic Leukemia	ABL1 NSD2 KMT2A	2.90e-03	52	161	3	C0023452
Disease	triacylglycerol 46:0 measurement	FMN1 WDR72	2.97e-03	15	161	2	EFO_0010400
Disease	phosphatidylcholine 36:3 measurement	KIF2B FADS2	2.97e-03	15	161	2	EFO_0010381
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	2.97e-03	15	161	2	DOID:13413 (biomarker_via_orthology)
Disease	diffuse plaque measurement	FMO4 ANK2 SHB MGLL METTL4 EVX2 PPP1R26 PHF2 PHOX2A EYS WDR72	3.07e-03	758	161	11	EFO_0010699
Disease	phosphatidylcholine 32:2 measurement	METTL4 FADS2	3.38e-03	16	161	2	EFO_0010374
Disease	Pheochromocytoma, Extra-Adrenal	KIF1B TMEM127	3.38e-03	16	161	2	C1257877
Disease	Schizophrenia	DOCK4 GRIN2A LEP GSN HSPA12A ADSS2 PAK2 FADS2 KMT2A SEPTIN7 NKAPL RAI1	3.42e-03	883	161	12	C0036341
Disease	response to statin	TDRD15 ACVR2A FADS2	3.58e-03	56	161	3	GO_0036273
Disease	Liver Cirrhosis, Experimental	STARD13 LEP CEMIP2 GSN COQ10A ACSL1 AHNAK GZMA PC ZDHHC13 PRLR	3.60e-03	774	161	11	C0023893
Disease	bacterial pathogen genotype measurement, pulmonary tuberculosis	DAP ATP13A2	3.81e-03	17	161	2	EFO_0010271, EFO_1000049
Disease	1-Methylhistidine measurement	ALMS1 KIF2B	3.81e-03	17	161	2	EFO_0021543
Disease	venous thromboembolism	ANK2 DGKB MGLL GRIN2A METTL4 PPARGC1B PHOX2A CCR4	3.88e-03	460	161	8	EFO_0004286
Disease	platelet-to-lymphocyte ratio	RBMS1 KIF1B CBL BAZ2A TPX2 FADS2 RAI1	3.90e-03	363	161	7	EFO_0008446
Disease	creatinine measurement, glomerular filtration rate	CYP24A1 ACVR2A ALMS1 WDR72	3.93e-03	117	161	4	EFO_0004518, EFO_0005208
Disease	amino acid measurement	DGKB TACC2 ACVR2A RYR2 ALMS1 KIF2B FMN1 GLUD1 HBE1 MUC2	4.20e-03	678	161	10	EFO_0005134
Disease	nevus count	PPARGC1B FMN1	4.27e-03	18	161	2	EFO_0004632
Disease	Tachycardia	LEP RYR2	4.27e-03	18	161	2	C0039231
Disease	Tachyarrhythmia	LEP RYR2	4.27e-03	18	161	2	C0080203
Disease	Myeloid Leukemia	SETBP1 KMT2A	4.27e-03	18	161	2	C0023470
Disease	Leukemia, Monocytic, Chronic	SETBP1 KMT2A	4.27e-03	18	161	2	C0023466
Disease	response to antipsychotic drug	SPATA6L EYS PRLR	4.34e-03	60	161	3	GO_0097332
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	ABL1 NSD2 KMT2A	4.55e-03	61	161	3	C1961102
Disease	smoking status measurement	NSF RBMS1 NOL6 RNF13 MGLL GRIN2A RYR2 STAB1 ALMS1 PTPRF KIF2B FEZF1 SETBP1 WDR72	4.64e-03	1160	161	14	EFO_0006527
Disease	chronic obstructive pulmonary disease	EEFSEC RBMS1 KIF1B SHB TASP1 DGKB METTL4 PPARGC1B DOT1L PDZD2	4.65e-03	688	161	10	EFO_0000341
Disease	DiGeorge syndrome (implicated_via_orthology)	FOXN1 ZNF366	4.76e-03	19	161	2	DOID:11198 (implicated_via_orthology)
Disease	Juvenile Myelomonocytic Leukemia	CBL SETBP1	4.76e-03	19	161	2	C0349639
Disease	Pheochromocytoma	KIF1B TMEM127	4.76e-03	19	161	2	C0031511
Disease	fish consumption measurement	DGKB MICALL1 FEZF1	5.21e-03	64	161	3	EFO_0010139
Disease	Craniosynostosis	ZNF462 WDR35	5.27e-03	20	161	2	C0010278
Disease	Fetal Growth Retardation	NSD2 GLUD1	5.27e-03	20	161	2	C0015934
Disease	freckles	PPARGC1B HSPA12A	5.27e-03	20	161	2	EFO_0003963
Disease	cholesterol in very large VLDL measurement	TDRD15 CERT1 FADS2	5.44e-03	65	161	3	EFO_0022230
Disease	Obesity	HMGB2 LEP ACSL1 PPARGC1B RAI1	5.45e-03	205	161	5	C0028754

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGKLETKAGHPPAVK	DAP	6	P51397
HLLLFSKLKGPEGGS	ARHGEF40	1296	Q8TER5
PHLLKAFSKPGFQGE	CRYBG3	2666	Q68DQ2
GPPDIKGRASIFKVH	AFG3L2	476	Q9Y4W6
VKRKPEAPGSGHLAE	ALPK2	1711	Q86TB3
GKFLAFSGPHPKSKI	CDC14A	186	Q9UNH5
GLKPFEQVKGITLHP	ACSL1	646	P33121
KVLGFDPAKDVPSLG	BAZ2A	866	Q9UIF9
DIPGLKDGHKPAISH	ACVR2A	306	P27037
APLHSALGELPAKGK	EVX2	56	Q03828
TILHLPKKGDDVKPG	GZMA	131	P12544
DPRGPGVYILLSKKH	GZMA	236	P12544
PHFTEAGLKILRVPG	ALMS1	1821	Q8TCU4
PDFDLHLKGPKVKGD	AHNAK	2966	Q09666
VDLHLKAPKIGFSGP	AHNAK	4921	Q09666
GEKKEGHFSALPSLP	GIP	21	P09681
KEGIKAFGELFLPPL	CCR4	31	P51679
AKLAAHPRKGFPGSL	DOT1L	1286	Q8TEK3
GKTPHLGEPHKILSL	CCDC87	666	Q9NVE4
KGSQGPLPFHEKVLL	SLC25A10	91	Q9UBX3
VKVLAPGEFGNHRPK	BMP2K	396	Q9NSY1
LPGAHGTDFPDPKVK	FBXO6	116	Q9NRD1
KHGSGPVVPEKAVRF	RAG1	611	P15918
HGLSKGPLEKRPYLG	RAI1	1456	Q7Z5J4
FGLHPFKGTQTPLEK	RAI2	271	Q9Y5P3
GHPKSLFIGEKAVLL	RBM34	396	P42696
AVIGHFNGKFIKTPP	RBMS1	196	P29558
ADPKKPIGGNIIAHA	RAD51	281	Q06609
GHKSLFLDLPHKVGP	FMN1	466	Q68DA7
AGGKEKVLSHKIPEP	ANK2	2081	Q01484
KLFPHVTPKGINGID	CERT1	226	Q9Y5P4
HPDLEFVGKFLKPLL	FADS2	76	O95864
PKHYLLITAIDGGKP	PCDHA3	206	Q9Y5H8
APAKGSGSKVVPAHL	H1-8	301	Q8IZA3
HGPEKDFPLHLGKNV	MDC1	41	Q14676
SSHPLVPGKLKEAPA	MAGEB16	41	A2A368
HVLGKPLPKSGSVFI	EYS	2001	Q5T1H1
KTFHGTGLVPPVDKN	nan	221	A8MVJ9
ALLKFKPGAFIAGVP	LPCAT4	211	Q643R3
IGAHGKPVIFLHPKD	MCEE	151	Q96PE7
KPVIFLHPKDCGGVL	MCEE	156	Q96PE7
KPTGTPKALIFVSHG	MGLL	36	Q99685
SPSAILGNPKVKAHG	HBE1	51	P02100
PKIKSEHPGLSIGDT	HMGB2	111	P26583
GTLGVFSPKKTPHLV	KIF1B	521	O60333
HAVPGPAKDLLGSKR	MAPK8IP2	661	Q13387
PSHDASKVKAEGPGL	FLNB	841	O75369
AVELGKHPAKFSLVG	PLS3	466	P13797
KPNFHKPGGDTELIG	MUC2	1796	Q02817
FPGHLPLPTKVEAKA	MYLK3	236	Q32MK0
VKAGGTDHRKPLISP	PDZD2	1906	O15018
NGHDALPFIPADKLK	NSD2	66	O96028
GKHVTNSPFKILVGP	FLNC	2021	Q14315
KFNGAHIPGSPFKIR	FLNC	2481	Q14315
PLEAFPGIHKFKGQI	FMO4	156	P31512
PPKHKDSGTLTLGLL	NOL6	541	Q9H6R4
KKGHIENPGDGLFAP	DEPDC1	701	Q5TB30
KVTGLDFIPGLHPIL	LEP	56	P41159
APGHGFPLIKRKVQA	MICALL1	661	Q8N3F8
LEGPPHSGKTALAAK	NSF	541	P46459
KENLGPKPTIFGHRG	GDPD4	191	Q6W3E5
PEGHLKELYKATGGP	HSPA12A	331	O43301
LSHKLGLPPGKASEL	HAUS5	496	O94927
NKTGKPLPFGTLGVH	LIG3	566	P49916
PLPFGTLGVHKKAAF	LIG3	571	P49916
KDIIHDPGRGAPLAK	RPL8	46	P62917
SVFAKHGLEKLTPIG	GRPEL2	156	Q8TAA5
SLHPPLKIDGKTIGV	RBM5	296	P52756
AVGLVKPKAGIFQPH	NUP155	146	O75694
ASHLLPAGAKGPSKL	NUTM1	1051	Q86Y26
GGKDPLSANHSLKPL	PAK2	26	Q13177
SGPTFGIIVKHFPKL	ATP13A2	826	Q9NQ11
GLGLPVDIQHKAKPS	C2orf83	31	Q53S99
GEHKLHFIPALIGPF	DOCK4	1056	Q8N1I0
KINPFAHLPFGVGKR	CYP24A1	446	Q07973
RHTGKPLEVFPFGKT	CR1	431	P17927
RHTGKPLEVFPFGKA	CR1	881	P17927
DLLKHFAPGTRKGSP	C7orf57	81	Q8NEG2
RKFGKHGGTIPIVPT	GLUD1	476	P00367
LSVPKGIQFVGHPGK	CPAMD8	841	Q8IZJ3
HKPVSGTFDLELKPL	INPP5K	311	Q9BT40
RKGHLKAQLEVGFPP	COQ10A	126	Q96MF6
THPLLVFVNPKSGGK	DGKB	436	Q9Y6T7
TFGGHKSEKPALPRK	ABL1	751	P00519
VIHSPKKVPQFDGLG	ASIC5	256	Q9NY37
PLGLAKPAHLYDKGS	CEMIP2	1306	Q9UHN6
PKGVLGFPVVKADHK	LYST	2191	Q99698
LKDVPSPLHAGSKLF	MARF1	61	Q9Y4F3
GPFCGKTLPHRIETK	MASP2	256	O00187
EKPGFPVGLGKAHST	MAPKBP1	1326	O60336
AVGVLSHNKPSKLPG	KANSL3	256	Q9P2N6
PTFPGVKIKITHGKD	KMT2A	226	Q03164
RIPGLGKDFKSPHLN	SLC44A4	621	Q53GD3
KAASGSLHKDKPLPV	CBL	521	P22681
HPEFLKAGKEPGLQI	GSN	56	P06396
SDQLKKHGFKLGPAP	HLTF	161	Q14527
KHGFKLGPAPKTLGF	HLTF	166	Q14527
LLSKSKEPTPGGLNH	HDAC5	191	Q9UQL6
PHPKLEAATKALGGE	FLAD1	201	Q8NFF5
PLKLHFGGLLKYPES	PRDM13	481	Q9H4Q3
ITLFPDENKKHGLPG	RYR2	1736	Q92736
DGEEIHPLSVKFPKG	CFAP47	1351	Q6ZTR5
KFPKGRVIPGSHSGI	CFAP47	1361	Q6ZTR5
GTLKPEGVTEAKHPA	PPRC1	1261	Q5VV67
RKFGKHGGTIPIVPT	GLUD2	476	P49448
SPHKKPYEGLILGRV	METTL4	371	Q8N3J2
LKPLKPHFGDIQEGI	KIF2B	16	Q8N4N8
GTLGVFSPKKTPHLV	KIF1A	481	Q12756
GAHGDSKPVFIKVPE	PTPRF	26	P10586
LLKHPFLAKAGPPAS	PAK4	566	O96013
HIPKDHKPGTFPKAL	STARD13	396	Q9Y3M8
KTALGFPGIAPKIEF	SPATA6L	111	Q8N4H0
FKPIKHGSPEFCGIL	SHB	381	Q15464
EALHGPPKKILVEGA	ADSS1	241	Q8N142
HGFTEPILVPKKDGL	PHF2	121	O75151
DGLKGIKIVPGAAHI	TDRD15	1231	B5MCY1
PKLDSPVVGEFKGLF	FER1L5	1441	A0AVI2
ALKGFHPDPEALKGF	LIAT1	201	Q6ZQX7
ALKGFHPDPDALKGF	LIAT1	211	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	221	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	231	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	241	Q6ZQX7
ALKGFHPDPEALKGI	LIAT1	251	Q6ZQX7
ALKGIHPDPEALKGI	LIAT1	261	Q6ZQX7
ALKGIHPDPEALKGF	LIAT1	271	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	281	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	291	Q6ZQX7
ALKGFHPDPKALKGF	LIAT1	321	Q6ZQX7
ALKGFHPDPKALKGF	LIAT1	331	Q6ZQX7
ALKGFHPDPKALKGF	LIAT1	351	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	361	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	371	Q6ZQX7
ALKGFHPDPEALKGF	LIAT1	381	Q6ZQX7
AVKAAPGGHPVVKLL	NFATC4	441	Q14934
PGGHPVVKLLGYSEK	NFATC4	446	Q14934
FLQGALPKGEPKHSL	FEZF1	51	A0PJY2
TLALKGHSFKTPGPL	FOXN1	141	O15353
HKIFEGLGPKVELPL	NCOR1	251	O75376
GLSLKATPGAAHKLP	PPARGC1B	641	Q86YN6
KGGHLILVPEFSLPL	RNF13	166	O43567
PALKALFEHGLKKPS	SGSM3	566	Q96HU1
LFEHGLKKPSLLGGA	SGSM3	571	Q96HU1
VVKSSFPEKGHKRPG	TMEM69	231	Q5SWH9
PLDGYLGVADHKPLK	ST6GALNAC5	76	Q9BVH7
FPTGGFTPEIGKKKH	SPESP1	101	Q6UW49
PSPVFGSPHLLAKKD	PPP1R26	1126	Q5T8A7
ALHGPPKKILVEGAN	ADSS2	241	P30520
KPGVKHAPYISIAGD	TMEM150C	46	B9EJG8
KGPDAASKLPLVTPH	PSMC1	41	P62191
GPGLEAFVSAAKKLP	URB1	46	O60287
GSLKKFLFHPGDTVP	TMEM176B	41	Q3YBM2
VPEGAGFKGHLPKVQ	AHNAK2	1236	Q8IVF2
LPEGAGFKGHLPKVQ	AHNAK2	1731	Q8IVF2
KKGFTPLILAATAGH	ANKHD1	1086	Q8IWZ3
EKPLKYGHALLPGEG	NKAPL	291	Q5M9Q1
EKPVDSLHPGAGTAK	SPATA33	46	Q96N06
DDPAPHKKVGFVGIS	RNF213	2871	Q63HN8
PEFPHKISSTKGLGA	ZNF750	216	Q32MQ0
GKFKIHIPGGLSPES	EEFSEC	526	P57772
HIPGGLSPESKKILT	EEFSEC	531	P57772
HKVIGPEPTGFLLKF	ZDHHC13	191	Q8IUH4
LLAGGHKKESKVPPE	NAA35	696	Q5VZE5
FPGVLDTAKPGKLHT	PIK3R5	266	Q8WYR1
KLIDGFLKHEGPPAE	REV1	1111	Q9UBZ9
PKHLPGTAEIQAGKT	SLCO4C1	336	Q6ZQN7
APSGHGLKPLDIEFM	SEPTIN7	166	Q16181
GVLSSFHRKPGPALK	PHOX2A	266	O14813
DPIKDNGFGIKPKHS	ZNF592	151	Q92610
ALLHIFSGKPPEKLL	FAM90A2P	116	Q658T7
VPGPKIKGFDAHLLE	PRLR	271	P16471
PFHGLLPKKETGAAS	TPP2	11	P29144
LLEGGSLVKDSPPHK	WDR72	441	Q3MJ13
KELKGDGPFTIFVPH	STAB1	1606	Q9NY15
FEKPVLGALATPGEK	TACC2	1416	O95359
VGFLLPPRAKTDHGV	TMEM8B	421	A6NDV4
KKPGIHLSPGEFHKE	TSTD2	276	Q5T7W7
LGKSGSNLPISPKEH	SUCO	71	Q9UBS9
PGLNKAGKFPSLLTH	RPL10A	126	P62906
KFPVHPRKAVGSLAP	ZNF469	3666	Q96JG9
VFGKKLPAFATIPIH	ZNF598	76	Q86UK7
SLEHFGGKPVKQEPI	ZNF366	141	Q8N895
PHGPTLLFVKVTQGK	ZCCHC4	41	Q9H5U6
PGVFPKKQHASKLGG	ZNF462	1791	Q96JM2
LSLSGVFAVHKPKGP	TRUB1	66	Q8WWH5
PFGEHLGTLKVPGKE	WDR35	291	Q9P2L0
GLPQDFTGDTLKPKH	SETBP1	196	Q9Y6X0
HGGFPEPFRSKVLKD	PC	956	P11498
DGKAKTHISRLPPGA	TASP1	386	Q9H6P5
PEKPLKGSGFRCVHI	TOB2	46	Q14106
FLLDVFGPKHPALKI	TMEM127	111	O75204
ALKVLGKDHLPSSPG	nan	201	A6NL46
GEVPKFKALPLPHFD	TPX2	561	Q9ULW0
LVSAHGEKPTKPVGL	VN1R2	76	Q8NFZ6
RPKGLGVFFCKAPIH	VPS13D	3101	Q5THJ4
KGPKPVVFLQHGLLA	LIPA	76	P38571
GKAPHGPSFTIGKAI	GRIN2A	591	Q12879