Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate binding	RAG2 WASHC2C WASHC2A	4.01e-05	31	43	3	GO:0080025
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	RAG2 WASHC2C WASHC2A	5.80e-05	35	43	3	GO:0043325
GeneOntologyMolecularFunction	chromatin binding	RAG2 MPHOSPH8 GTF2F1 AKAP8 SBNO1 YY1 CHD5 POLR3G	1.56e-04	739	43	8	GO:0003682
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	RAG2 WASHC2C WASHC2A	1.60e-04	49	43	3	GO:0005547
GeneOntologyMolecularFunction	retromer complex binding	WASHC2C WASHC2A	2.02e-04	10	43	2	GO:1905394
GeneOntologyMolecularFunction	methylated histone binding	RAG2 MPHOSPH8 CHD5	8.41e-04	86	43	3	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	RAG2 MPHOSPH8 CHD5	8.99e-04	88	43	3	GO:0140034
GeneOntologyMolecularFunction	phosphatidylinositol-5-phosphate binding	WASHC2C WASHC2A	1.11e-03	23	43	2	GO:0010314
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	RAG2 WASHC2C WASHC2A	1.12e-03	95	43	3	GO:0005546
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate binding	RAG2 WASHC2C WASHC2A	2.24e-03	121	43	3	GO:1902936
GeneOntologyMolecularFunction	histone binding	RAG2 MPHOSPH8 SBNO1 CHD5	2.49e-03	265	43	4	GO:0042393
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	WASHC2C WASHC2A	2.72e-03	36	43	2	GO:0070273
GeneOntologyMolecularFunction	NF-kappaB binding	AKAP8 FAF1	2.72e-03	36	43	2	GO:0051059
GeneOntologyMolecularFunction	phosphotransferase activity, phosphate group as acceptor	CARD11 PMVK	3.52e-03	41	43	2	GO:0016776
HumanPheno	Abnormal cell proliferation	RAG2 CARD11 MCM10	1.17e-04	43	12	3	HP:0031377
HumanPheno	Abnormal lymphocyte proliferation	RAG2 CARD11 MCM10	1.17e-04	43	12	3	HP:0031378
HumanPheno	Abnormal cellular physiology	RAG2 CARD11 MCM10	1.17e-04	43	12	3	HP:0025462
Domain	FAM21	WASHC2C WASHC2A	5.68e-06	2	45	2	IPR027308
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	1.70e-05	3	45	2	IPR029341
Domain	CAP-ZIP_m	WASHC2C WASHC2A	1.70e-05	3	45	2	PF15255
Domain	Chromo_domain	MPHOSPH8 CHD5	1.51e-03	24	45	2	IPR023780
Domain	ZF_PHD_2	RAG2 BAZ2B CHD5	1.55e-03	95	45	3	PS50016
Domain	ZF_PHD_1	RAG2 BAZ2B CHD5	1.60e-03	96	45	3	PS01359
Domain	Chromo	MPHOSPH8 CHD5	1.78e-03	26	45	2	PF00385
Domain	CHROMO_2	MPHOSPH8 CHD5	2.06e-03	28	45	2	PS50013
Domain	CHROMO_1	MPHOSPH8 CHD5	2.06e-03	28	45	2	PS00598
Domain	C1Q	C1QTNF9B C1QTNF9	2.69e-03	32	45	2	SM00110
Domain	C1q	C1QTNF9B C1QTNF9	2.69e-03	32	45	2	PF00386
Domain	Chromodomain-like	MPHOSPH8 CHD5	2.69e-03	32	45	2	IPR016197
Domain	CHROMO	MPHOSPH8 CHD5	2.86e-03	33	45	2	SM00298
Domain	Chromo/shadow_dom	MPHOSPH8 CHD5	2.86e-03	33	45	2	IPR000953
Domain	C1q_dom	C1QTNF9B C1QTNF9	3.03e-03	34	45	2	IPR001073
Domain	C1Q	C1QTNF9B C1QTNF9	3.03e-03	34	45	2	PS50871
Domain	Znf_FYVE_PHD	RAG2 BAZ2B CHD5	5.32e-03	147	45	3	IPR011011
Domain	PDZ	CARD11 PDZD4 PDZD2	5.42e-03	148	45	3	SM00228
Domain	-	CARD11 PDZD4 PDZD2	5.63e-03	150	45	3	2.30.42.10
Domain	PDZ	CARD11 PDZD4 PDZD2	5.73e-03	151	45	3	PS50106
Domain	PDZ	CARD11 PDZD4 PDZD2	5.84e-03	152	45	3	IPR001478
Domain	-	C1QTNF9B C1QTNF9	6.46e-03	50	45	2	2.60.120.40
Domain	Laminin_G	EGFLAM THBS2	8.61e-03	58	45	2	IPR001791
Domain	Tumour_necrosis_fac-like_dom	C1QTNF9B C1QTNF9	8.61e-03	58	45	2	IPR008983
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	MCM10 SRSF6 WASHC2A SBNO1 PRRC2A BUB1	6.92e-07	242	45	6	34011540
Pubmed	C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	24030394
Pubmed	C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	36766785
Pubmed	Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	37945738
Pubmed	CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	22514273
Pubmed	A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer.	SRSF4 SRSF6	1.64e-06	2	45	2	7651409
Pubmed	CTRP 9 mitigates the apoptosis and unfolded protein response of OGD/R-induced retinal ganglion cells by regulating the AMPK pathway.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	38741428
Pubmed	C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	25783894
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	1.64e-06	2	45	2	15847701
Pubmed	C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	21836066
Pubmed	Autoantibodies Against β1-Adrenoceptor Exaggerated Ventricular Remodeling by Inhibiting CTRP9 Expression.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	30764693
Pubmed	CTRP9 Regulates Growth, Differentiation, and Apoptosis in Human Keratinocytes through TGFβ1-p38-Dependent Pathway.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	29145717
Pubmed	Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	24473438
Pubmed	Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	22972916
Pubmed	Globular CTRP9 inhibits oxLDL-induced inflammatory response in RAW 264.7 macrophages via AMPK activation.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	27188183
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	1.64e-06	2	45	2	20827171
Pubmed	Expression of Yin Yang 1 in cervical cancer and its correlation with E-cadherin expression and HPV16 E6.	CDH1 YY1	1.64e-06	2	45	2	29470526
Pubmed	Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	35575905
Pubmed	Overexpression of CTRP9 attenuates the development of atherosclerosis in apolipoprotein E-deficient mice.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	30426302
Pubmed	Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3.	SRSF4 SRSF6	1.64e-06	2	45	2	20685659
Pubmed	CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	29749459
Pubmed	C1q/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of endoplasmic reticulum stress.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	26419929
Pubmed	CTRP9 induces iNOS expression through JAK2/STAT3 pathway in Raw 264.7 and peritoneal macrophages.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	31837806
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	1.64e-06	2	45	2	36717248
Pubmed	C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	28978553
Pubmed	Association of C1q/TNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	32831639
Pubmed	C1q/Tumor Necrosis Factor-Related Protein-9 Attenuates Diabetic Nephropathy and Kidney Fibrosis in db/db Mice.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	32283037
Pubmed	CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	38940054
Pubmed	C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	27821723
Pubmed	The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.	SCN10A YY1	1.64e-06	2	45	2	23433317
Pubmed	Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	26754066
Pubmed	CTRP9 alleviates foam cells apoptosis by enhancing cholesterol efflux.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	33352225
Pubmed	C1q/tumour necrosis factor-related protein-9 aggravates lipopolysaccharide-induced inflammation via promoting NLRP3 inflammasome activation.	C1QTNF9B C1QTNF9	1.64e-06	2	45	2	35008006
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	GPALPP1 ZSWIM8 SNX33 WASHC2C WASHC2A PRRC2A DMXL1	2.46e-06	475	45	7	31040226
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	SRSF4 SRSF6 YY1 PRRC2A DMXL1 POLR3G	4.09e-06	329	45	6	34316702
Pubmed	CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway.	C1QTNF9B C1QTNF9	4.91e-06	3	45	2	31930700
Pubmed	Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency.	C1QTNF9B C1QTNF9	4.91e-06	3	45	2	35115674
Pubmed	C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism.	C1QTNF9B C1QTNF9	4.91e-06	3	45	2	25870106
Pubmed	CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction.	C1QTNF9B C1QTNF9	4.91e-06	3	45	2	23842676
Pubmed	C1q/TNF-related protein-9 attenuates retinal inflammation and protects blood-retinal barrier in db/db mice.	C1QTNF9B C1QTNF9	4.91e-06	3	45	2	30978318
Pubmed	Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis.	C1QTNF9B C1QTNF9	4.91e-06	3	45	2	29925877
Pubmed	CTRP9 enhances carotid plaque stability by reducing pro-inflammatory cytokines in macrophages.	C1QTNF9B C1QTNF9	4.91e-06	3	45	2	25701788
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SNX33 AFTPH AKAP8 WASHC2C SRSF6 YY1 PRRC2A EIF2B5	6.04e-06	774	45	8	15302935
Pubmed	A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation.	RAG2 YY1	9.81e-06	4	45	2	26302788
Pubmed	Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin.	C1QTNF9B C1QTNF9	9.81e-06	4	45	2	18787108
Pubmed	CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members.	C1QTNF9B C1QTNF9	9.81e-06	4	45	2	19666007
Pubmed	BCL-6 promotes the methylation of miR-34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury.	C1QTNF9B C1QTNF9	9.81e-06	4	45	2	33502806
Pubmed	C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel Vasculoprotective Cytokine That Restores High Glucose-Suppressed Endothelial Progenitor Cell Functions by Activating the Endothelial Nitric Oxide Synthase.	C1QTNF9B C1QTNF9	9.81e-06	4	45	2	38348774
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	MRPS31 EGFLAM HIVEP2 WASHC2A PRRC2A	1.10e-05	226	45	5	25900982
Pubmed	CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation.	C1QTNF9B C1QTNF9	1.63e-05	5	45	2	27349872
Pubmed	MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition.	MPHOSPH8 CDH1	1.63e-05	5	45	2	25870236
Pubmed	Lysine acetylation targets protein complexes and co-regulates major cellular functions.	KIAA0930 SRSF4 SRSF6	1.65e-05	38	45	3	19608861
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	SRSF4 AKAP8 SRSF6 PRRC2A ARHGEF10L	2.07e-05	258	45	5	37794589
Pubmed	Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements.	SRSF4 SRSF6	2.45e-05	6	45	2	17361132
Pubmed	YY1 Is Required for Posttranscriptional Stability of SOX2 and OCT4 Proteins.	CDH1 YY1	2.45e-05	6	45	2	28682643
Pubmed	SR proteins: a conserved family of pre-mRNA splicing factors.	SRSF4 SRSF6	2.45e-05	6	45	2	1577277
Pubmed	IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.	CARD11 NDFIP1	2.45e-05	6	45	2	22547705
Pubmed	Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.	RAG2 YY1	2.45e-05	6	45	2	23973221
Pubmed	In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.	RAG2 BAZ2B	2.45e-05	6	45	2	35090595
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	GPALPP1 GTF2F1 AKAP8 SBNO1	2.47e-05	130	45	4	35545047
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	MRPS31 ZSWIM8 MCM10 SRSF4 AKAP8 SRSF6 PRRC2A FAF1 NOB1	4.48e-05	1335	45	9	29229926
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	4.56e-05	8	45	2	19922874
Pubmed	WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase.	CDH1 BUB1	4.56e-05	8	45	2	15388328
Pubmed	Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance.	THBS2 CDH1	4.56e-05	8	45	2	17202846
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	GPALPP1 ZSWIM8 GTF2F1 AFTPH SRSF6 WASHC2A NOB1 EIF2B5	4.95e-05	1038	45	8	26673895
Pubmed	Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.	SRSF4 SRSF6	5.86e-05	9	45	2	15009664
Pubmed	The SR protein family.	SRSF4 SRSF6	5.86e-05	9	45	2	19857271
Pubmed	Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.	SRSF4 SRSF6	7.32e-05	10	45	2	10983978
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	AMBRA1 KIAA0930 HIVEP2 WASHC2A ENDOG CHD5 ARHGEF10L NOB1	7.68e-05	1105	45	8	35748872
Pubmed	Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions.	C1QTNF9B C1QTNF9	1.07e-04	12	45	2	18783346
Pubmed	The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.	WASHC2C WASHC2A	1.07e-04	12	45	2	19922875
Pubmed	Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.	WASHC2C WASHC2A	1.07e-04	12	45	2	27390154
Pubmed	A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.	CDH1 YY1	1.07e-04	12	45	2	27802136
Pubmed	Morphogenetic analysis of peri-implantation development.	CDH1 YY1	1.07e-04	12	45	2	23728800
Pubmed	A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).	SRSF4 SRSF6	1.27e-04	13	45	2	20516191
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MPHOSPH8 MCM10 SBNO1 YY1 BAZ2B CHD5	1.27e-04	608	45	6	36089195
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	BAZ2B PRRC2A	1.47e-04	14	45	2	28878358
Pubmed	Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.	WASHC2C WASHC2A	1.70e-04	15	45	2	28892079
Pubmed	Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis.	CDH1 YY1	1.70e-04	15	45	2	33158935
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	SRSF4 AKAP8 SRSF6 SBNO1 FAF1 NOB1	1.87e-04	653	45	6	33742100
Pubmed	Tracing the origin of adult intestinal stem cells.	RAG2 CDH1	1.94e-04	16	45	2	31092921
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	MRPS31 AMBRA1 GTF2F1 AFTPH NOB1	1.99e-04	417	45	5	36537216
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	SRSF4 AKAP8 SRSF6	2.13e-04	89	45	3	22446626
Pubmed	Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.	SCN10A FAF1	2.20e-04	17	45	2	21076409
Pubmed	Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.	RAG2 CDH1	2.20e-04	17	45	2	35709757
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SCN10A AFTPH ENDOG CHD5 BUB1	2.30e-04	430	45	5	35044719
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	AMBRA1 HIVEP2 AKAP8 PRRC2A	2.32e-04	232	45	4	25515538
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	MRPS31 AMBRA1 AKAP8 SRSF6 PRRC2A BUB1 NOB1	2.33e-04	971	45	7	33306668
Pubmed	YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.	RAG2 CDH1	2.47e-04	18	45	2	29249464
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MRPS31 AMBRA1 KIAA0930 SNX33 SRSF6 SBNO1 BUB1 EIF2B5	2.61e-04	1321	45	8	27173435
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	WASHC2C WASHC2A	2.76e-04	19	45	2	25355947
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	SRSF4 AKAP8 SRSF6 PRRC2A	2.81e-04	244	45	4	29884807
Pubmed	Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.	MCM10 CDH1	3.06e-04	20	45	2	26023099
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	EGFLAM SRSF4 AKAP8 NOB1	3.13e-04	251	45	4	28077445
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	WASHC2C WASHC2A CDH1	3.27e-04	103	45	3	29539633
Pubmed	Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation.	CDH1 YY1	3.72e-04	22	45	2	22669107
Pubmed	Comprehensive proteomic analysis of the human spliceosome.	GTF2F1 SRSF4 SRSF6	3.86e-04	109	45	3	12226669
Pubmed	Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.	WASHC2C WASHC2A	4.07e-04	23	45	2	31748650
Pubmed	Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation.	PMVK CDH1	4.07e-04	23	45	2	16998848
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	GTF2F1 AFTPH AKAP8 WASHC2C PRRC2A	4.70e-04	503	45	5	16964243
Interaction	GNL2 interactions	MRPS31 GTF2F1 MCM10 SRSF4 SRSF6 PRRC2A NOB1 POLR3G	1.95e-06	386	45	8	int:GNL2
Cytoband	13q12.12	C1QTNF9B C1QTNF9	2.35e-04	23	45	2	13q12.12
Cytoband	Ensembl 112 genes in cytogenetic band chr13q12	C1QTNF9B MPHOSPH8 C1QTNF9	1.58e-03	234	45	3	chr13q12
GeneFamily	WASH complex	WASHC2C WASHC2A	3.98e-05	6	30	2	1331
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF4 SRSF6	1.74e-04	12	30	2	737
GeneFamily	Endogenous ligands\|C1q and TNF related	C1QTNF9B C1QTNF9	4.01e-04	18	30	2	1372
GeneFamily	PDZ domain containing	CARD11 PDZD4 PDZD2	2.00e-03	152	30	3	1220
GeneFamily	RNA binding motif containing	PABPN1L SRSF4 SRSF6	5.18e-03	213	30	3	725
GeneFamily	PHD finger proteins	BAZ2B CHD5	9.74e-03	90	30	2	88
Drug	Thiamphenicol [15318-45-3]; Down 200; 11.2uM; PC3; HT_HG-U133A	AMBRA1 GTF2F1 HIVEP2 CDH1 BUB1 POLR3G	2.15e-06	198	44	6	1826_DN
Disease	skin disease (implicated_via_orthology)	C1QTNF9B C1QTNF9	6.22e-06	3	43	2	DOID:37 (implicated_via_orthology)
Disease	brain infarction	THBS2 SNX33	3.13e-04	18	43	2	EFO_0004277
Disease	colon adenocarcinoma (is_marker_for)	SRSF4 SRSF6	6.09e-04	25	43	2	DOID:234 (is_marker_for)
Disease	clear cell renal cell carcinoma (is_marker_for)	SRSF4 SRSF6	1.06e-03	33	43	2	DOID:4467 (is_marker_for)
Disease	blood titanium measurement	BAZ2B PDZD2	1.27e-03	36	43	2	EFO_0021532
Disease	renal cell carcinoma	FAF1 PDZD2	1.72e-03	42	43	2	EFO_0000681
Disease	sex interaction measurement, inflammatory bowel disease	PRRC2A NDFIP1	2.93e-03	55	43	2	EFO_0003767, EFO_0008343
Disease	Colorectal Carcinoma	SRSF6 CDH1 CHD5 ARHGEF10L BUB1	3.43e-03	702	43	5	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
DAEEDQDGDAGFLLS	PABPN1L	56	A6NDY0
EAEDDPGEAFEFDDS	ARHGEF10L	26	Q9HCE6
GAGEDDEGFEDDLDL	EGFLAM	256	Q63HQ2
GNGFLEQDDEDDLSA	BUB1	926	O43683
SEEEDGGLEAFDDFF	CHD5	26	Q8TDI0
DFSENDDAAGDFRSG	AKAP8	326	O43823
DDAAGDFRSGDEEFK	AKAP8	331	O43823
EDDDDDEFGEFGGFS	AFTPH	21	Q6ULP2
DINEDDFGDFGDFGS	AFTPH	426	Q6ULP2
RRKGGDSDYDDDDDD	BAZ2B	1291	Q9UIF8
GTDLEFEDFEDNGDR	AMBRA1	771	Q9C0C7
AFGRNEDEFGLNEDA	DMXL1	2086	Q9Y485
FSAEANSFDGDDEFD	RAG2	386	P55895
ENGFEDRKDDSDDDG	NOB1	191	Q9ULX3
NDSEEFFREDDGGAD	KIAA0930	326	Q6ICG6
DDGEFSDDSGADQEK	EIF2B5	461	Q13144
AGARAQEDEDGDYEE	PCSK9	26	Q8NBP7
DANDASDEEEFDREG	PDZD2	966	O15018
DRDDFLDDFGSENEG	PDZD4	226	Q76G19
AFDELFDADGDGESY	MCM10	41	Q7L590
EDFVGRDDFDDADQL	NDFIP1	96	Q9BT67
TGGERFNGLFADEDD	C1QTNF9	306	P0C862
QRGSGDFDDFNLEDA	CD99L2	21	Q8TCZ2
GNDFDLADALDDRND	CD99L2	116	Q8TCZ2
DSDSDDFGEADGRYF	GPAT2	661	Q6NUI2
DDDDDDDDGFFGPAL	GPALPP1	81	Q8IXQ4
TGGERFNGLFADEDD	C1QTNF9B	306	B2RNN3
SDGDDFEDATEFGVD	FAF1	291	Q9UNN5
GDDDDFNPFLDESNE	SBNO1	756	A3KN83
NDSGGFDALDLDDDS	CARD11	591	Q9BXL7
DEEGGGEEDQDFDLS	CDH1	756	P12830
EDNDAAARGAEAFGD	MPHOSPH8	36	Q99549
EAFGDSEEDGEDVFE	MPHOSPH8	46	Q99549
NNEAGFDDDGSEFHE	MRPS31	316	Q92665
EAFEDSDDGDFEGQE	GTF2F1	256	P35269
GYGFVEFDDLRDADD	SRSF4	36	Q08170
GDGDRRECDFREDDS	ENDOG	106	Q14249
FSDEEDGRDSDEEGA	PRRC2A	341	P48634
GFLSNQGSFEEDDDD	SNX33	101	Q8WV41
GYGFVEFEDSRDADD	SRSF6	36	Q13247
DAESECGLDNFGDFD	PMVK	151	Q15126
LDDLEDDGGEDAQSF	SCN10A	1006	Q9Y5Y9
DDSDGLRAEDGFEDQ	YY1	116	P25490
SLFDDEDEEDNLFGG	WASHC2C	571	Q9Y4E1
GSLFGDDEDDDLFSS	WASHC2C	876	Q9Y4E1
NSYFEDGDDFGADSD	POLR3G	201	O15318
GERFSFEDSDRFEED	ZSWIM8	11	A7E2V4
SLFDDEDEEDNLFGG	WASHC2A	571	Q641Q2
GSLFGDDEDDDLFSS	WASHC2A	876	Q641Q2
DGRGDICKDDFDNDN	THBS2	926	P35442
QFSDAEESDGEDGDD	HIVEP2	1896	P31629