Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	RIPOR2 ABL2 FGD2 PTPRO FGD4 DNAH17 CFAP61 CPLANE1 CFAP44 KIF24 SH3YL1	5.18e-06	670	63	11	GO:0120031
GeneOntologyBiologicalProcess	cell projection assembly	RIPOR2 ABL2 FGD2 PTPRO FGD4 DNAH17 CFAP61 CPLANE1 CFAP44 KIF24 SH3YL1	6.39e-06	685	63	11	GO:0030031
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly actin filament organization	PLEC IQGAP3	5.49e-05	4	63	2	GO:2000689
GeneOntologyCellularComponent	calpain complex	CAPN1 CAPN2	5.01e-05	4	61	2	GO:0110158
GeneOntologyCellularComponent	caspase complex	CAPN1 CAPN2	3.71e-04	10	61	2	GO:0008303
Domain	PL48	RIPOR2 RIPOR3	3.35e-05	3	63	2	PF15903
Domain	FAM65_N	RIPOR2 RIPOR3	3.35e-05	3	63	2	IPR031780
Domain	FAM65	RIPOR2 RIPOR3	3.35e-05	3	63	2	IPR026136
Domain	ARM-like	RIPOR2 AP1G1 PKP3 RIPOR3 HUWE1 TRRAP	2.94e-04	270	63	6	IPR011989
Domain	Calpain_III	CAPN1 CAPN2	7.23e-04	12	63	2	IPR022683
Domain	calpain_III	CAPN1 CAPN2	7.23e-04	12	63	2	SM00720
Domain	C2_III	CAPN1 CAPN2	7.23e-04	12	63	2	IPR033883
Domain	Calpain_domain_III	CAPN1 CAPN2	8.53e-04	13	63	2	IPR022682
Domain	Calpain_III	CAPN1 CAPN2	8.53e-04	13	63	2	PF01067
Domain	-	RIPOR2 AP1G1 PKP3 RIPOR3 TRRAP	9.10e-04	222	63	5	1.25.10.10
Domain	ARM-type_fold	RIPOR2 AP1G1 PKP3 NUP188 HUWE1 TRRAP	9.74e-04	339	63	6	IPR016024
Domain	Calpain_cysteine_protease	CAPN1 CAPN2	9.93e-04	14	63	2	IPR022684
Domain	CysPc	CAPN1 CAPN2	1.14e-03	15	63	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN1 CAPN2	1.14e-03	15	63	2	IPR001300
Domain	Peptidase_C2	CAPN1 CAPN2	1.14e-03	15	63	2	PF00648
Domain	CALPAIN_CAT	CAPN1 CAPN2	1.14e-03	15	63	2	PS50203
Domain	RhoGEF	FGD2 FGD4 MCF2	1.57e-03	68	63	3	SM00325
Domain	RhoGEF	FGD2 FGD4 MCF2	1.70e-03	70	63	3	PF00621
Domain	DH_2	FGD2 FGD4 MCF2	1.70e-03	70	63	3	PS50010
Domain	DH-domain	FGD2 FGD4 MCF2	1.78e-03	71	63	3	IPR000219
Domain	-	FGD2 FGD4 MCF2	1.78e-03	71	63	3	1.20.900.10
Domain	THIOL_PROTEASE_CYS	CAPN1 CAPN2	3.45e-03	26	63	2	PS00139
Domain	TPR_1	TTC16 SRP72 TTC6	3.49e-03	90	63	3	PF00515
Domain	TPR_1	TTC16 SRP72 TTC6	3.49e-03	90	63	3	IPR001440
Domain	THIOL_PROTEASE_ASN	CAPN1 CAPN2	3.72e-03	27	63	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN1 CAPN2	3.72e-03	27	63	2	PS00639
Domain	Pept_cys_AS	CAPN1 CAPN2	4.00e-03	28	63	2	IPR000169
Domain	FYVE	FGD2 FGD4	4.29e-03	29	63	2	PF01363
Domain	FYVE	FGD2 FGD4	4.29e-03	29	63	2	SM00064
Domain	Spectrin_repeat	MCF2 PLEC	4.29e-03	29	63	2	IPR002017
Domain	Spectrin/alpha-actinin	MCF2 PLEC	5.20e-03	32	63	2	IPR018159
Domain	SPEC	MCF2 PLEC	5.20e-03	32	63	2	SM00150
Domain	EF-hand_8	CAPN1 CAPN2	5.86e-03	34	63	2	PF13833
Domain	Znf_FYVE-rel	FGD2 FGD4	5.86e-03	34	63	2	IPR017455
Domain	Znf_FYVE	FGD2 FGD4	7.28e-03	38	63	2	IPR000306
Domain	TPR-like_helical_dom	TTC16 SRP72 TRRAP TTC6	7.91e-03	233	63	4	IPR011990
Domain	ZF_FYVE	FGD2 FGD4	8.04e-03	40	63	2	PS50178
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	YEATS2 MYOF ABL2 CAPN2 MCM7 PLEC HUWE1 DUS1L	1.76e-07	332	64	8	37433992
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	XRN2 AP1G1 TCP1 CAPN1 MCM7 NUP188 HUWE1 TRRAP IQGAP3 TOE1	6.13e-07	704	64	10	29955894
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	YEATS2 MYOF XRN2 PKP3 SHCBP1 PLEC HUWE1 TRRAP USP16 ADCY6	1.44e-06	774	64	10	15302935
Pubmed	Calpains are required for invasive and metastatic potentials of human HCC cells.	CAPN1 CAPN2	3.33e-06	2	64	2	23733271
Pubmed	Involvement of calpains in growth factor-mediated migration.	CAPN1 CAPN2	3.33e-06	2	64	2	16971167
Pubmed	Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.	CAPN1 CAPN2	3.33e-06	2	64	2	29258546
Pubmed	Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.	CAPN1 CAPN2	3.33e-06	2	64	2	28594313
Pubmed	Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury.	CAPN1 CAPN2	3.33e-06	2	64	2	22140070
Pubmed	[Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice].	CAPN1 CAPN2	3.33e-06	2	64	2	17619446
Pubmed	Calpain 1 and 2 are required for RNA replication of echovirus 1.	CAPN1 CAPN2	3.33e-06	2	64	2	18032503
Pubmed	Calpain-2 participates in the process of calpain-1 inactivation.	CAPN1 CAPN2	3.33e-06	2	64	2	33078830
Pubmed	Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.	CAPN1 CAPN2	3.33e-06	2	64	2	22335024
Pubmed	Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.	CAPN1 CAPN2	3.33e-06	2	64	2	27622212
Pubmed	Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.	CAPN1 CAPN2	3.33e-06	2	64	2	19781581
Pubmed	Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.	CAPN1 CAPN2	3.33e-06	2	64	2	27185592
Pubmed	Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.	CAPN1 CAPN2	3.33e-06	2	64	2	22432027
Pubmed	Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant.	CAPN1 CAPN2	3.33e-06	2	64	2	9669314
Pubmed	Cerebral calpain in fatal falciparum malaria.	CAPN1 CAPN2	3.33e-06	2	64	2	17359359
Pubmed	Vitamin D₃ regulation of body fat, cytokines, and calpain gene expression.	CAPN1 CAPN2	3.33e-06	2	64	2	25520983
Pubmed	Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes.	CAPN1 CAPN2	3.33e-06	2	64	2	19505932
Pubmed	Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.	CAPN1 CAPN2	3.33e-06	2	64	2	30177812
Pubmed	Calpains: markers of tumor aggressiveness?	CAPN1 CAPN2	3.33e-06	2	64	2	20193680
Pubmed	Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.	CAPN1 CAPN2	3.33e-06	2	64	2	15471877
Pubmed	m-Calpain is required for preimplantation embryonic development in mice.	CAPN1 CAPN2	3.33e-06	2	64	2	16433929
Pubmed	Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling.	MYOF CAPN1	3.33e-06	2	64	2	28192161
Pubmed	Different expression of calpains in the anterior vaginal wall of women with and without uterovaginal prolapse.	CAPN1 CAPN2	3.33e-06	2	64	2	14980313
Pubmed	Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.	CAPN1 CAPN2	3.33e-06	2	64	2	16723743
Pubmed	Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration.	CAPN1 CAPN2	3.33e-06	2	64	2	24285894
Pubmed	Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus.	CAPN1 CAPN2	3.33e-06	2	64	2	15302874
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	XRN2 AP1G1 TCP1 CAPN1 SHCBP1 CAPN2 MCM7 PLEC HUWE1 TRRAP USP16 TOE1	5.78e-06	1353	64	12	29467282
Pubmed	Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition.	CAPN1 CAPN2	9.99e-06	3	64	2	30177525
Pubmed	The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.	CAPN1 CAPN2	9.99e-06	3	64	2	28924170
Pubmed	The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.	CAPN1 CAPN2	9.99e-06	3	64	2	18840650
Pubmed	Expression and immunolocalization of the calpain-calpastatin system in the human oocyte.	CAPN1 CAPN2	9.99e-06	3	64	2	15950654
Pubmed	Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.	CAPN1 CAPN2	9.99e-06	3	64	2	19318376
Pubmed	Expression of typical calpains in mouse molar.	CAPN1 CAPN2	9.99e-06	3	64	2	19683220
Pubmed	NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain.	CAPN1 CAPN2	9.99e-06	3	64	2	8954122
Pubmed	Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.	CAPN1 CAPN2	9.99e-06	3	64	2	23977256
Pubmed	Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs.	CAPN1 CAPN2	9.99e-06	3	64	2	21839844
Pubmed	Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension.	CAPN1 CAPN2	9.99e-06	3	64	2	26974350
Pubmed	The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells.	CAPN1 CAPN2	9.99e-06	3	64	2	21374734
Pubmed	Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains.	CAPN1 CAPN2	9.99e-06	3	64	2	16361262
Pubmed	A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling.	CAPN1 CAPN2	9.99e-06	3	64	2	21415394
Pubmed	LOX-1 in macrophage migration in response to ox-LDL and the involvement of calpains.	CAPN1 CAPN2	9.99e-06	3	64	2	26393906
Pubmed	Neurotoxicity induces cleavage of p35 to p25 by calpain.	CAPN1 CAPN2	9.99e-06	3	64	2	10830966
Pubmed	Utrophin is a calpain substrate in muscle cells.	CAPN1 CAPN2	9.99e-06	3	64	2	16598790
Pubmed	SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.	EOGT SHCBP1	9.99e-06	3	64	2	33515675
Pubmed	Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.	CAPN1 CAPN2	9.99e-06	3	64	2	24550490
Pubmed	A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.	CAPN1 CAPN2	9.99e-06	3	64	2	28334907
Pubmed	Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.	CAPN1 CAPN2	9.99e-06	3	64	2	16632474
Pubmed	Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations.	CAPN1 CAPN2	9.99e-06	3	64	2	3038169
Pubmed	Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.	CAPN1 CAPN2	9.99e-06	3	64	2	23536090
Pubmed	Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.	TCP1 PKP3 MCM7 PLEC BAHCC1	1.15e-05	159	64	5	34537242
Pubmed	Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.	AP1G1 TCP1 PKP3 MCM7 IQGAP3	1.22e-05	161	64	5	36398662
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	MYOF XRN2 AP1G1 TCP1 CAPN1 MCM7 PLEC HUWE1 IQGAP3	1.64e-05	807	64	9	30575818
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	MYOF XRN2 TCP1 PKP3 CAPN1 SRP72 MCM7 PLEC USP16 IQGAP3 TOE1	1.69e-05	1257	64	11	36526897
Pubmed	Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.	CAPN1 CAPN2	2.00e-05	4	64	2	27456359
Pubmed	Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord.	CAPN1 CAPN2	2.00e-05	4	64	2	8738748
Pubmed	Calpain: novel family members, activation, and physiologic function.	CAPN1 CAPN2	2.00e-05	4	64	2	8561910
Pubmed	Inhibition of the ERK1/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro.	CAPN1 CAPN2	2.00e-05	4	64	2	32017927
Pubmed	Characterization of the calcium-dependent proteolytic system in a mouse muscle cell line.	CAPN1 CAPN2	2.00e-05	4	64	2	11952156
Pubmed	Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.	FGD2 FGD4	2.00e-05	4	64	2	17564959
Pubmed	Four genes for the calpain family locate on four distinct human chromosomes.	CAPN1 CAPN2	2.00e-05	4	64	2	2209092
Pubmed	Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.	CAPN1 CAPN2	2.00e-05	4	64	2	16998475
Pubmed	17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation.	CAPN1 CAPN2	2.00e-05	4	64	2	19995977
Pubmed	Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.	CAPN1 CAPN2	2.00e-05	4	64	2	12634108
Pubmed	Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration.	CAPN1 CAPN2	2.00e-05	4	64	2	35606145
Pubmed	Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events.	CAPN1 CAPN2	2.00e-05	4	64	2	9407132
Pubmed	The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway.	CAPN1 CAPN2	2.00e-05	4	64	2	27453531
Pubmed	Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.	CAPN1 CAPN2	2.00e-05	4	64	2	26966280
Pubmed	Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization.	CAPN1 CAPN2	2.00e-05	4	64	2	22555453
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	MYOF TCP1 CAPN1 CAPN2 SRP72	2.21e-05	182	64	5	30711629
Pubmed	High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.	PLXNA4 MCM7 NOSTRIN	2.33e-05	30	64	3	19401682
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	TCP1 PKP3 MCM7 PLEC	2.37e-05	90	64	4	35654790
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	JARID2 XRN2 MCM7 HUWE1 TRRAP USP16 TOE1	2.48e-05	469	64	7	27634302
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	CAPN1 CAPN2 HUWE1	2.84e-05	32	64	3	36278411
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYOF FNTB LMX1B NUP188 PLEC HUWE1 TRRAP IQGAP3 DUS1L BAHCC1	3.21e-05	1105	64	10	35748872
Pubmed	Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.	CAPN1 CAPN2	3.32e-05	5	64	2	17646163
Pubmed	Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.	MYOF RIPOR2	3.32e-05	5	64	2	24687993
Pubmed	Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division.	CAPN1 CAPN2	3.32e-05	5	64	2	10825211
Pubmed	m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.	CAPN1 CAPN2	3.32e-05	5	64	2	22064597
Pubmed	The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells.	CAPN1 CAPN2	3.32e-05	5	64	2	20041182
Pubmed	Calpain translocation during muscle fiber necrosis and regeneration in dystrophin-deficient mice.	CAPN1 CAPN2	3.32e-05	5	64	2	8806430
Pubmed	Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells.	CAPN1 CAPN2	3.32e-05	5	64	2	12150984
Pubmed	Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation.	CAPN1 CAPN2	3.32e-05	5	64	2	21836084
Pubmed	Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.	CAPN1 CAPN2	3.32e-05	5	64	2	12000759
Pubmed	Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity.	CAPN1 CAPN2	3.32e-05	5	64	2	17897354
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	TCP1 MCM7 HUWE1 TRRAP IQGAP3	4.47e-05	211	64	5	17314511
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	FGD2 FGD4 MCF2	4.79e-05	38	64	3	11756498
Pubmed	Association of the calpain/calpastatin network with subcellular organelles.	CAPN1 CAPN2	4.98e-05	6	64	2	14559243
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	XRN2 AP1G1 CAPN2 SRP72 TRRAP IQGAP3	5.67e-05	364	64	6	24778252
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TCP1 BCORL1 PLXNA4 EEF1AKMT1 NUP188 SLFN5 HUWE1 CFAP44	6.03e-05	736	64	8	29676528
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	FGD2 FGD4 MCF2	6.96e-05	43	64	3	12376548
Pubmed	N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.	CAPN1 CAPN2	6.96e-05	7	64	2	16530191
Pubmed	Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.	CAPN1 CAPN2	6.96e-05	7	64	2	25944670
Pubmed	Structure and physiological function of calpains.	CAPN1 CAPN2	6.96e-05	7	64	2	9396712
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	CAPN1 CAPN2	6.96e-05	7	64	2	20962236
Pubmed	Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.	TGFB2 LMX1B ATOH8	7.98e-05	45	64	3	22696295
Pubmed	ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.	TCP1 PKP3 CAPN2	8.53e-05	46	64	3	20890123
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	CERS5 TCP1 CAPN1 SRP72 MCM7 NUP188 HUWE1	8.57e-05	571	64	7	37167062
Cytoband	17q25.3	DNAH17 DUS1L BAHCC1	3.91e-04	101	64	3	17q25.3
Cytoband	14q23.3	FNTB PPP1R36	6.08e-04	26	64	2	14q23.3
Cytoband	9q34.11	TTC16 NUP188	2.52e-03	53	64	2	9q34.11
Cytoband	Ensembl 112 genes in cytogenetic band chr1q41	TGFB2 CAPN2	7.54e-03	93	64	2	chr1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	DNAH17 DUS1L BAHCC1	9.13e-03	307	64	3	chr17q25
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD2 FGD4 MCF2	5.91e-04	66	45	3	722
GeneFamily	C2 domain containing\|Calpains	CAPN1 CAPN2	6.23e-04	15	45	2	975
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	FGD2 FGD4	2.69e-03	31	45	2	81
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC16 SRP72 TTC6	2.93e-03	115	45	3	769
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO SHCBP1 DNAH17 PPP1R36 KIF24	4.12e-06	166	64	5	a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCell	facs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO SHCBP1 DNAH17 PPP1R36 KIF24	4.12e-06	166	64	5	0f641302a6b71c4badaaf20f51162bfc2386b167
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_Hsd17b2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYOF IMPG1 LMX1B ATOH8	5.70e-06	81	64	4	20796e59cdeb398e7772f4356578d74a33405f71
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	TTC16 CFAP61 CFAP44 KIF24 TTC6	9.00e-06	195	64	5	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	(01)_IL1RL1+-(1)_GFP\|(01)_IL1RL1+ / shred by cell type by condition	PKP3 CAPN1 CAPN2 DUSP7 PLEC	9.23e-06	196	64	5	b598b1112242534e139318012b257ed3cb09da83
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYOF PKP3 CAPN1 DUSP7 MCM7	9.46e-06	197	64	5	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFB2 ATOH8 PKP3 CAPN2 SH3YL1	9.69e-06	198	64	5	5a85c286f79cde5811d2595a3397c6fb7685adee
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGFB2 ATOH8 PKP3 CAPN2 SH3YL1	9.69e-06	198	64	5	1282db321e27499d310339d6383974614e295a20
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFB2 MYOF ATOH8 PKP3 SH3YL1	9.69e-06	198	64	5	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	Control_saline-Epithelial_alveolar-AT_1-AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	MYOF ATOH8 PKP3 CAPN2 SH3YL1	9.69e-06	198	64	5	9f972f217d2c39d4c0f7d0d4227d0fffe8535b9d
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TGFB2 MYOF ATOH8 PKP3 SH3YL1	9.93e-06	199	64	5	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFB2 MYOF ATOH8 PKP3 SH3YL1	9.93e-06	199	64	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	Skin-Keratinocytes\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	PKP3 CAPN1 DUSP7 SRP72 HUWE1	1.02e-05	200	64	5	59d72395199bc30df0e811fbc99149694e208860
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MCM7 EEF1AKMT1 KIF24 IQGAP3	5.22e-05	142	64	4	e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Trps1_(Medial_entorrhinal_cortex,_Cbln1+/Trps1+)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LMX1B MAB21L2 TTC6	5.44e-05	51	64	3	10cfed29c2fa495d4527e1e4d8edf21edaf1d0fa
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Trps1_(Medial_entorrhinal_cortex,_Cbln1+/Trps1+)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LMX1B MAB21L2 TTC6	5.44e-05	51	64	3	9656b37262f228753203ca49aab93e86066b69a5
ToppCell	droplet-Bladder-nan-3m-Hematologic-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO TTC16 PLXNA4 IQGAP3	6.62e-05	151	64	4	a7b1a60d68f0ed17022fe4c97af64f9f08d39fa3
ToppCell	droplet-Marrow-BM-30m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO CAPN2 SLFN5 SH3YL1	8.70e-05	162	64	4	76e289ad9fd3694f77fd0d19e74c1cb8e87b8094
ToppCell	droplet-Heart-nan-18m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 SHCBP1 KIF24 IQGAP3	8.70e-05	162	64	4	7f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCell	10x5'-Liver-Hematopoietic_progenitors\|Liver / Manually curated celltypes from each tissue	SHCBP1 KIF24 IQGAP3 BAHCC1	9.56e-05	166	64	4	ae967570248cf86ca3ddf55e33bcbb3e4e3684bc
ToppCell	10x5'-Liver-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Liver / Manually curated celltypes from each tissue	SHCBP1 KIF24 IQGAP3 BAHCC1	9.56e-05	166	64	4	a176e87aa6eec81d1fb79a028f759182d11b567d
ToppCell	droplet-Lung-LUNG-30m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGD2 PKP3 IQGAP3 ADCY6	1.00e-04	168	64	4	0e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)\|Striatum / BrainAtlas - Mouse McCarroll V32	IMPG1 MCF2 CFAP44 ZNF445	1.02e-04	169	64	4	c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--\|Striatum / BrainAtlas - Mouse McCarroll V32	IMPG1 MCF2 CFAP44 ZNF445	1.02e-04	169	64	4	5375eb52ebadccb7bfff997a11985f23e81014d6
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGD4 SHCBP1 KIF24 IQGAP3	1.02e-04	169	64	4	4db49b7eaea34e6558ee73b01e76315e99cc880b
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-\|Striatum / BrainAtlas - Mouse McCarroll V32	IMPG1 MCF2 CFAP44 ZNF445	1.02e-04	169	64	4	1c132d21255f5a5174ac38db4e91927f9093418e
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIPOR2 PDE6A TTC16 PKP3	1.12e-04	173	64	4	da0f1461643294f92e20b5e456a50211a2780a91
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGD2 SHCBP1 MCM7 IQGAP3	1.12e-04	173	64	4	6c9ecf77d2fb0f89100fdd7e4e88f85598278bc7
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 PDE6A PKP3 MCM7	1.15e-04	174	64	4	fedadde222df1952d6456f4f3413c01579146e1f
ToppCell	droplet-Thymus-nan-24m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF PTPRO FGD4 NOSTRIN	1.15e-04	174	64	4	44c21521991ad4789783d73d5aa4993a22876886
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 PDE6A PKP3 MCM7	1.15e-04	174	64	4	e69a011ae9698368923223d3af3243e609c08c83
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ATOH8 SHCBP1 KIF24 IQGAP3	1.17e-04	175	64	4	f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCell	ASK452-Epithelial-Secretory\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	YEATS2 MYOF ATOH8 TTC6	1.20e-04	176	64	4	dd334c8a8a31dc26b2d558df0ef6bed6dc1a6610
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIPOR2 TTC16 PLXNA4 RIPOR3	1.22e-04	177	64	4	84591e28482ab62a5ef41e61043eb64912766356
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC16 CFAP61 PPP1R36 CFAP44	1.22e-04	177	64	4	ae01c19403a09f7ba5e4beafdfcd1b8eebdadcb7
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIPOR2 TTC16 PLXNA4 RIPOR3	1.22e-04	177	64	4	4bc100062891d07cacd10ffba38966cc6302c92f
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIPOR2 TTC16 PLXNA4 RIPOR3	1.22e-04	177	64	4	9f3a2adb9cd4f0a059afc87b6e377a9702154bb1
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC16 CFAP61 PPP1R36 CFAP44	1.22e-04	177	64	4	bd3d07bdef6e903995d4bbfb6ff3a5e1d9fb70cc
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCM7 PPP1R36 CFAP44 KIF24	1.25e-04	178	64	4	6178706db4a855d72abc156537604d575624df56
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCM7 PPP1R36 CFAP44 KIF24	1.25e-04	178	64	4	f02076ece0fa899e620971c887ad4da7f48684ed
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-MAIT_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	XRN2 PTPRO CFAP44 ZNF443	1.25e-04	178	64	4	0290868dc990878eac5c182fe64968333bc52450
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHCBP1 MCM7 KIF24 IQGAP3	1.28e-04	179	64	4	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	10x5'v1-week_12-13-Lymphocytic_T-T_NK-CD8_T_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RIPOR2 PDE6A TTC16 SLFN5	1.31e-04	180	64	4	5273aa2b939b5c640d708d6ca1812550dff5ec0f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	TGFB2 PTPRO AGMAT RIPOR3	1.33e-04	181	64	4	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC16 CFAP61 PPP1R36 CFAP44	1.36e-04	182	64	4	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC16 CFAP61 PPP1R36 CFAP44	1.36e-04	182	64	4	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR2C MCM7 KIF24 IQGAP3	1.39e-04	183	64	4	42dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SRP72 EEF1AKMT1 LRRC37B DUS1L	1.51e-04	187	64	4	c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCell	facs-Lung-EPCAM-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC16 CFAP61 PPP1R36 CFAP44	1.51e-04	187	64	4	051b8c07d7489ce7576f6c57ce7008767ef76869
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC16 CFAP61 PPP1R36 CFAP44	1.51e-04	187	64	4	888856cde7a69ea2f14d590597e25b1af6383c51
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SRP72 EEF1AKMT1 LRRC37B DUS1L	1.57e-04	189	64	4	99b01893da9f9f7c9528afaffad178285211738b
ToppCell	facs-Skin-Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF ATOH8 PKP3 CAPN1	1.57e-04	189	64	4	adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell	Int-URO-Lymphocyte-T_NK-T_NK_proliferative\|Int-URO / Disease, Lineage and Cell Type	SHCBP1 MCM7 KIF24 IQGAP3	1.61e-04	190	64	4	005967c540418b85311308072a07c684f4296aef
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTC16 CFAP61 PPP1R36 CFAP44	1.61e-04	190	64	4	9ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTC16 CFAP61 PPP1R36 CFAP44	1.61e-04	190	64	4	3ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCell	facs-Skin-Anagen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF PKP3 CAPN1 CAPN2	1.61e-04	190	64	4	888ded899f0513d41bf655896d59ae8ef74e0978
ToppCell	facs-Skin-Anagen-3m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF PKP3 CAPN1 CAPN2	1.61e-04	190	64	4	3466cebab16964e94da130d0673fa32e7d90b5ed
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTC16 CFAP61 PPP1R36 CFAP44	1.64e-04	191	64	4	649fcb62ad15de2f83e61591e43923a717664ae7
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTC16 CFAP61 PPP1R36 CFAP44	1.64e-04	191	64	4	9621e22e14ea069f22713947c9faa2d882abe5fe
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T\|GI_small-bowel / Manually curated celltypes from each tissue	SHCBP1 MCM7 KIF24 IQGAP3	1.64e-04	191	64	4	e642fa7395c05fb53324c9d46bbc52f89fc9673f
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SHCBP1 MCF2 MCM7 IQGAP3	1.64e-04	191	64	4	50854384fdaa0efa2e3227659d544ed09ac102f2
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	JARID2 ABL2 FGD4 RIPOR3	1.74e-04	194	64	4	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	10x5'v1-week_12-13-Lymphocytic_T\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RIPOR2 TTC16 AGMAT SLFN5	1.74e-04	194	64	4	4abc925820d23793d6ebf83fd7df8e75b32f09b4
ToppCell	10x5'v1-week_12-13-Lymphocytic_T-T_NK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RIPOR2 TTC16 AGMAT SLFN5	1.74e-04	194	64	4	b1ed9b7ea9298dc3ce900a2c6b0a2ca6412f1f5f
ToppCell	facs-Skin-Anagen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF ATOH8 PKP3 CAPN2	1.74e-04	194	64	4	5d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCell	(1)_T_cells-(1)_T_cells_Dividing\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	SHCBP1 MCM7 KIF24 IQGAP3	1.77e-04	195	64	4	cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	JARID2 RIPOR2 FGD2 FGD4	1.81e-04	196	64	4	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SHCBP1 MCM7 KIF24 IQGAP3	1.81e-04	196	64	4	1d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JARID2 ABL2 FGD4 DNAH17	1.81e-04	196	64	4	01cea0bb0b938d0986fd2ddae06597b8af1768ee
ToppCell	Healthy_Control-Lymphoid-T-Proliferating_T\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	ATOH8 SHCBP1 MCM7 IQGAP3	1.84e-04	197	64	4	3ce3dcbbe0edeb5a6fb5596dd6c2b4d6c1d5159d
ToppCell	COVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi\|lung / Disease (COVID-19 only), tissue and cell type	JARID2 RIPOR2 FGD2 FGD4	1.84e-04	197	64	4	3896729740d151f0eb845f1961c7b969bfbdd28d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SHCBP1 MCM7 KIF24 IQGAP3	1.84e-04	197	64	4	8b616cde333bdbc0c591035ad9e4949155866245
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-GC_B_(I)\|GI_large-bowel / Manually curated celltypes from each tissue	SHCBP1 MCM7 KIF24 IQGAP3	1.84e-04	197	64	4	80a0cfbd454409594effead7082586b06c2f411a
ToppCell	T_cells-CTLs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	RIPOR2 TTC16 CAPN2 SLFN5	1.84e-04	197	64	4	2de34e20915a247bee75aa40495e23c20bb23e18
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYOF PKP3 CAPN1 SH3YL1	1.88e-04	198	64	4	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGFB2 ATOH8 PKP3 SH3YL1	1.88e-04	198	64	4	50852713c017217c79777c95857097103bcf2fbe
ToppCell	Control_saline-Epithelial_airway\|Control_saline / Treatment groups by lineage, cell group, cell type	TTC16 CFAP61 CFAP44 TTC6	1.88e-04	198	64	4	e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFB2 ATOH8 PKP3 SH3YL1	1.88e-04	198	64	4	8d9858dcb21f20d0c040b22a2cae543eaebd54bc
ToppCell	Control_saline-Epithelial_airway-airway_epithelial\|Control_saline / Treatment groups by lineage, cell group, cell type	TTC16 CFAP61 CFAP44 TTC6	1.88e-04	198	64	4	e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCell	Control_saline-Epithelial_alveolar-AT_1\|Control_saline / Treatment groups by lineage, cell group, cell type	MYOF ATOH8 PKP3 SH3YL1	1.88e-04	198	64	4	9b161285df7a4e51618f3517cfc5b8221ba55786
ToppCell	Control_saline-Epithelial_alveolar\|Control_saline / Treatment groups by lineage, cell group, cell type	MYOF ATOH8 PKP3 SH3YL1	1.88e-04	198	64	4	532b7ef4ad46fe35ad2c6bdf89f70a17f1a2e2e2
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	SHCBP1 MCM7 KIF24 IQGAP3	1.92e-04	199	64	4	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TGFB2 ATOH8 PKP3 SH3YL1	1.92e-04	199	64	4	8c9ec5f05b79cf5ae1bf7aade603c171fb0226a9
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FGD2 PTPRO BCORL1 KIF24	1.92e-04	199	64	4	c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TTC16 CFAP44 KIF24 TTC6	1.92e-04	199	64	4	15f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCell	Biopsy_Other_PF-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SHCBP1 MCM7 KIF24 IQGAP3	1.92e-04	199	64	4	d73667e2e93026d95184e24ff0bc90afd1fb74a9
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	TGFB2 ATOH8 PKP3 SH3YL1	1.92e-04	199	64	4	ccdde5d4bcc72f230a1dd2544ee7f4dfb98a5e80
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABL2 RIPOR3 PLEC TOE1	1.95e-04	200	64	4	88d713dfc792e7609bf7ecfb28f87cb748088570
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TGFB2 MYOF ATOH8 PKP3	1.95e-04	200	64	4	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGFB2 MYOF ATOH8 PKP3	1.95e-04	200	64	4	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-T/NK_proliferative\|Int-URO / Disease, condition lineage and cell class	SHCBP1 MCM7 KIF24 IQGAP3	1.95e-04	200	64	4	99acc1ea01288efdd5b166aa20d66735f2bbe543
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / Treatment groups by lineage, cell group, cell type	TGFB2 ATOH8 PKP3 SH3YL1	1.95e-04	200	64	4	9a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Lpl-Penk_(Layer_2/3)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IMPG1 AGMAT PPP1R36	2.33e-04	83	64	3	b683c8496474b0df0042f596c9b0ea5916a2ab15
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A	ABCC1 MYOF CAPN1 SRP72 MCM7 USP16 TOE1	1.34e-06	197	64	7	1732_DN
Disease	Charcot-Marie-Tooth disease type 4H (implicated_via_orthology)	FGD2 FGD4	2.77e-05	4	64	2	DOID:0110192 (implicated_via_orthology)
Disease	X-linked Aarskog syndrome (implicated_via_orthology)	FGD2 FGD4	2.77e-05	4	64	2	DOID:6683 (implicated_via_orthology)
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN1 CAPN2	4.61e-05	5	64	2	DOID:0110821 (implicated_via_orthology)
Disease	anorectal malformation	PKP3 NLRP8	7.73e-04	19	64	2	MONDO_0019938
Disease	lymphocyte count	CERS5 JARID2 ABCC1 RIPOR2 PKP3 DNAH17 DZIP3 RIPOR3 PLEC NOSTRIN	1.15e-03	1464	64	10	EFO_0004587
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	FGD2 FGD4	1.24e-03	24	64	2	DOID:10595 (implicated_via_orthology)
Disease	traumatic brain injury (biomarker_via_orthology)	CAPN1 CAPN2	1.24e-03	24	64	2	DOID:0081292 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQYCRATNLYLDLRN	EOGT	151	Q5NDL2
SRKCQDRQDLYYLAG	BAHCC1	2606	Q9P281
NLCARYDENLITDLY	CFAP61	1126	Q8NHU2
YGNLLDYLRECNREE	ABL2	366	P42684
LARERRNDELYYQSC	ADCY6	961	O43306
RRAFSNYLRCNYKVE	HTR2C	376	P28335
QRAARLGYKDVVLYC	BCORL1	1501	Q5H9F3
RDANYRKENLYCEVC	DUS1L	56	Q6P1R4
KYLGQDYEQLRVRCL	CAPN1	36	P07384
AAKLANYAKYQRLCD	CERS5	256	Q8N5B7
YDCRKRANLQLLDDS	CFAP44	141	Q96MT7
DDCYYINRRKRLVQL	MSL3P1	111	P0C860
EDNTYRCRNVAKLLY	AP1G1	41	O43747
CNYILSLARLADLDY	ATOH8	276	Q96SQ7
LILRKNSLENCGAYY	NLRP8	821	Q86W28
DSLQAYYRLRVCQEA	IMPG1	91	Q17R60
DYKENRLIACGSLYQ	PLXNA4	121	Q9HCM2
KALYTVRAFLNCDRY	PDE6A	261	P16499
YVNRLDLLDQVFYCK	FGD4	221	Q96M96
YQKLRELCRENFSIY	EEF1AKMT1	86	Q8WVE0
EIYCGQLYDLLNRRK	KIF24	361	Q5T7B8
QYLDLSCNKIRYIER	LRRC37B	606	Q96QE4
KAVYDNRLLECYFTR	HUWE1	4116	Q7Z6Z7
LARQRQLYKLHYQCE	DZIP3	751	Q86Y13
RQNVAYQYLCRLEEA	IQGAP3	26	Q86VI3
ICENARRYAKLFADA	MCM7	66	P33993
LNRCKNRYTNILPYD	PTPRO	961	Q16827
RDKLSYSCRQYQKAR	CPLANE1	1286	Q9H799
NINKDNYRARLLYGD	DNAH17	86	Q9UFH2
LLLQKLRDDGCQAYY	DUSP7	156	Q16829
QLNKYYTERCQARKA	MAB21L2	11	Q9Y586
YALDLICQRCNELRY	MCF2	291	P10911
RCSDYRAELKYDDNR	FGD2	491	Q7Z6J4
YLKRGLRQLTDAYEC	FNTB	81	P49356
KYLNQDYEALRNECL	CAPN2	26	P17655
QDRLAKLQEAYCQYL	JARID2	691	Q92833
RLCKALYSFQARQDD	NOSTRIN	441	Q8IVI9
RNYCLRYREDLDFVL	ABCC1	1296	P33527
ADRCQGLRELALNYY	FBXL21P	226	Q9UKT6
NRKFYCQDIRAYDIL	SH3YL1	176	Q96HL8
YRLACKEAVRYINEN	TCP1	121	P17987
LYNLQDSCRRIQEAY	AGMAT	131	Q9BSE5
RFRAYQDYILADCKA	SHCBP1	81	Q8NEM2
YCEYRLNRIENALKT	SRP72	86	O76094
ELYEAYCIQRRLQDG	RIPOR2	141	Q9Y4F9
NAVCVLRNLSYRLYD	PKP3	526	Q9Y446
KRALDAAYCFRNVQD	TGFB2	301	P61812
AQALYKACLYAEATR	TTC30B	86	Q8N4P2
CLYQFTRNEKLRDAN	USP16	636	Q9Y5T5
AFYNRALCYTKIREL	TTC6	141	Q86TZ1
RLAFYYDLDKQTRCV	RIPOR3	111	Q96MK2
AKCLRYYIADRLNND	XRN2	171	Q9H0D6
NIEDQYRYPRKNLRC	ZNF799	51	Q96GE5
QLLQCYLQEDYRGTR	NUP188	91	Q5SRE5
SELEAAQRYLAQKYC	PPP1R36	191	Q96LQ0
AYRDCLGRLDLQYAK	PLEC	726	Q15149
NLCGKSYDRNYRLVN	ZNF445	871	P59923
NIEDQYRYPRKNLRC	ZNF443	51	Q9Y2A4
DFYALRAEAYLQLCD	TTC16	96	Q8NEE8
RCENCDERFQYKYQL	ZNF652	386	Q9Y2D9
LNYCKRNYGDIELLF	TRRAP	1701	Q9Y4A5
IYVANKCRFLLRNGY	SLFN5	771	Q08AF3
ASYLEYAFRKCEREN	TOE1	241	Q96GM8
DKLRACIVANYYASA	YEATS2	76	Q9ULM3
FRDRKLYCKQDYQQL	LMX1B	96	O60663
LRCYVYQARNLLALD	MYOF	1141	Q9NZM1