Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncGMP-dependent protein kinase activity

PRKG1 PRKG2

3.12e-0521122GO:0004692
GeneOntologyMolecularFunctionprotein serine kinase activity

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ATM ULK1 PRKG1 PRKG2 DCLK1

3.81e-0536311210GO:0106310
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

PLK2 CAMK2G KSR2 OBSCN SOSTDC1 PIK3R4 ATM ULK1 PRKG1 PRKG2 DCLK1

4.23e-0544611211GO:0004674
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

GABRD UTS2R GPR18 LMBR1 SOSTDC1 OR5M11 PTPRT GPR139 GFRA2 CRHR2 OR10G7 OR10G4 OR10D4P LIFR P2RY6 OR4K1 OR10G8 IL5RA UNC5D EPHB1

5.84e-05135311220GO:0004888
GeneOntologyMolecularFunctionprotein kinase activity

PLK2 CAMK2G KSR2 OBSCN SOSTDC1 PIK3R4 ATM ULK1 PRKG1 PRKG2 DCLK1 EPHB1

1.39e-0460011212GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

PLK2 CAMK2G KSR2 OBSCN SOSTDC1 PIK3R4 ATM ULK1 PRKG1 PRKG2 DCLK1 EPHB1

6.30e-0470911212GO:0016773
DomainGprotein_B

CHAF1B GNB2 WDSUB1

2.38e-05101113IPR001632
DomaincGMP_dep_kinase

PRKG1 PRKG2

3.50e-0521112IPR002374
DomainSer/Thr_kinase_AS

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ULK1 PRKG1 PRKG2 DCLK1

2.81e-043571119IPR008271
DomainS_TKc

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ULK1 PRKG1 PRKG2 DCLK1

2.93e-043591119SM00220
DomainPROTEIN_KINASE_ST

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ULK1 PRKG1 PRKG2 DCLK1

3.11e-043621119PS00108
DomainKinase-like_dom

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ATM ULK1 PRKG1 PRKG2 DCLK1 EPHB1

3.83e-0454211111IPR011009
DomainPkinase

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ULK1 PRKG1 PRKG2 DCLK1

4.51e-043811119PF00069
Domain-

HFE MYOM3 OBSCN ADAMTSL3 PTPRT LIFR BTN2A2 BTN1A1 ILDR1 IL5RA UNC5D EPHB1

5.78e-04663111122.60.40.10
DomainProt_kinase_dom

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ULK1 PRKG1 PRKG2 DCLK1 EPHB1

6.71e-0448911110IPR000719
DomainPROTEIN_KINASE_DOM

PLK2 CAMK2G KSR2 OBSCN PIK3R4 ULK1 PRKG1 PRKG2 DCLK1 EPHB1

7.14e-0449311110PS50011
DomainCa/CaM-dep_Ca-dep_prot_Kinase

PLK2 CAMK2G ULK1 DCLK1

7.59e-04691114IPR020636
DomainCNMP_BINDING_1

PNPLA6 PRKG1 PRKG2

8.94e-04321113PS00888
DomainCNMP_BINDING_2

PNPLA6 PRKG1 PRKG2

8.94e-04321113PS00889
DomainHP

AVIL SVIL

9.57e-0481112PS51089
Domain-

AVIL SVIL

9.57e-04811121.10.950.10
DomainVillin/Gelsolin

AVIL SVIL

9.57e-0481112IPR007122
DomainVHP

AVIL SVIL

9.57e-0481112SM00153
DomainVHP

AVIL SVIL

9.57e-0481112PF02209
DomainVillin_headpiece

AVIL SVIL

9.57e-0481112IPR003128
DomainGEL

AVIL SVIL

9.57e-0481112SM00262
DomainIg-like_fold

HFE MYOM3 OBSCN ADAMTSL3 PTPRT LIFR BTN2A2 BTN1A1 ILDR1 IL5RA UNC5D EPHB1

1.00e-0370611112IPR013783
DomaincNMP

PNPLA6 PRKG1 PRKG2

1.07e-03341113SM00100
DomaincNMP_binding

PNPLA6 PRKG1 PRKG2

1.07e-03341113PF00027
DomaincNMP-bd_dom

PNPLA6 PRKG1 PRKG2

1.16e-03351113IPR000595
DomainCNMP_BINDING_3

PNPLA6 PRKG1 PRKG2

1.16e-03351113PS50042
DomainFN3

MYOM3 OBSCN PTPRT LIFR IL5RA EPHB1

1.22e-031991116PS50853
DomaincNMP-bd-like

PNPLA6 PRKG1 PRKG2

1.48e-03381113IPR018490
DomainFN3_dom

MYOM3 OBSCN PTPRT LIFR IL5RA EPHB1

1.56e-032091116IPR003961
DomainPROTEIN_KINASE_ATP

PLK2 CAMK2G OBSCN PIK3R4 ULK1 PRKG1 PRKG2 DCLK1 EPHB1

1.67e-034591119PS00107
DomainProtein_kinase_ATP_BS

PLK2 CAMK2G OBSCN ULK1 PRKG1 PRKG2 DCLK1 EPHB1

1.92e-033791118IPR017441
DomainWD40_repeat_dom

CHAF1B WDR19 PIK3R4 ZNF106 GNB2 WDSUB1 ANAPC4

1.99e-032971117IPR017986
DomainFERM_M

PTPN21 TLN2 PLEKHH2

2.58e-03461113PF00373
DomainIG_LIKE

HFE MYOM3 OBSCN ADAMTSL3 PTPRT BTN2A2 BTN1A1 ILDR1 UNC5D

2.64e-034911119PS50835
Domainfn3

MYOM3 OBSCN PTPRT LIFR EPHB1

2.83e-031621115PF00041
Domain-

PNPLA6 PRKG1 PRKG2

2.91e-034811132.60.120.10
DomainGelsolin

AVIL SVIL

3.04e-03141112PF00626
DomainDynein_heavy_chain_D4_dom

DNAH3 DYNC1H1

3.04e-03141112IPR024317
DomainDynein_HC_stalk

DNAH3 DYNC1H1

3.04e-03141112IPR024743
DomainDynein_heavy_dom-2

DNAH3 DYNC1H1

3.04e-03141112IPR013602
DomainDHC_N2

DNAH3 DYNC1H1

3.04e-03141112PF08393
DomainGelsolin-like_dom

AVIL SVIL

3.04e-03141112IPR007123
DomainATPase_dyneun-rel_AAA

DNAH3 DYNC1H1

3.04e-03141112IPR011704
DomainMT

DNAH3 DYNC1H1

3.04e-03141112PF12777
DomainAAA_8

DNAH3 DYNC1H1

3.04e-03141112PF12780
DomainAAA_5

DNAH3 DYNC1H1

3.04e-03141112PF07728
Domain-

PTPN21 TLN2 PLEKHH2

3.09e-034911131.20.80.10
DomainFERM_central

PTPN21 TLN2 PLEKHH2

3.09e-03491113IPR019748
DomainFERM_domain

PTPN21 TLN2 PLEKHH2

3.09e-03491113IPR000299
DomainIg-like_dom

HFE MYOM3 OBSCN ADAMTSL3 PTPRT BTN2A2 BTN1A1 ILDR1 UNC5D

3.09e-035031119IPR007110
DomainFERM/acyl-CoA-bd_prot_3-hlx

PTPN21 TLN2 PLEKHH2

3.27e-03501113IPR014352
DomainFERM_1

PTPN21 TLN2 PLEKHH2

3.27e-03501113PS00660
DomainFERM_2

PTPN21 TLN2 PLEKHH2

3.27e-03501113PS00661
DomainFERM_3

PTPN21 TLN2 PLEKHH2

3.27e-03501113PS50057
DomainBand_41_domain

PTPN21 TLN2 PLEKHH2

3.27e-03501113IPR019749
DomainB41

PTPN21 TLN2 PLEKHH2

3.27e-03501113SM00295
DomainRmlC-like_jellyroll

PNPLA6 PRKG1 PRKG2

3.46e-03511113IPR014710
DomainDHC_fam

DNAH3 DYNC1H1

3.49e-03151112IPR026983
DomainDynein_heavy

DNAH3 DYNC1H1

3.49e-03151112PF03028
DomainDynein_heavy_dom

DNAH3 DYNC1H1

3.49e-03151112IPR004273
DomainIG

MYOM3 OBSCN ADAMTSL3 PTPRT BTN2A2 BTN1A1 ILDR1 UNC5D

3.65e-034211118SM00409
DomainIg_sub

MYOM3 OBSCN ADAMTSL3 PTPRT BTN2A2 BTN1A1 ILDR1 UNC5D

3.65e-034211118IPR003599
Domain-

CHAF1B WDR19 PIK3R4 ZNF106 GNB2 WDSUB1 ANAPC4

3.75e-0333311172.130.10.10
DomainWD40/YVTN_repeat-like_dom

CHAF1B WDR19 PIK3R4 ZNF106 GNB2 WDSUB1 ANAPC4

3.88e-033351117IPR015943
DomaincNMP-bd_CS

PRKG1 PRKG2

3.98e-03161112IPR018488
DomainHEAT_type_2

CLASP1 PIK3R4

4.49e-03171112IPR021133
DomainWD40

CHAF1B WDR19 PIK3R4 ZNF106 GNB2 WDSUB1

4.52e-032591116PF00400
DomainFN3

MYOM3 OBSCN PTPRT LIFR EPHB1

4.97e-031851115SM00060
DomainWD40

CHAF1B WDR19 PIK3R4 ZNF106 GNB2 WDSUB1

5.33e-032681116SM00320
DomainARM-like

CLASP1 PIK3R4 AP5Z1 TTC12 LTN1 AGBL1

5.52e-032701116IPR011989
DomainWD40_repeat

CHAF1B WDR19 PIK3R4 ZNF106 GNB2 WDSUB1

5.72e-032721116IPR001680
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

CHAF1B CLASP1 RALGAPB USP19 EIF3CL NCOR1 MSH6 ZNF106 EEF2 PNPLA6 SVIL SENP6 TLN2 ATM UNC5D XRCC6

4.63e-097741131615302935
Pubmed

Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.

CAMK2G RYR1 PRKG1

1.33e-07411338380342
Pubmed

Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.

CAMK2G RYR1 PRKG1

1.33e-074113314532276
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

KCTD13 CLASP1 CAMK2G LRRC49 DHX57 OPHN1 EIF3CL PIK3R4 EEF2 PNPLA6 MTERF2 KCTD10 SVIL TLN2 GNB2 HSDL1 DCLK1 DYNC1H1

8.48e-0714311131837142655
Pubmed

Mouse HORMAD1 is a meiosis i checkpoint protein that modulates DNA double- strand break repair during female meiosis.

HORMAD1 ATM NOBOX

1.85e-068113323759310
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CLASP1 CAMK2G KSR2 NOSIP NCOR1 EEF2 ARHGEF7 SVIL TLN2 SPATS2 GNB2 DCLK1 DYNC1H1 XRCC6

3.06e-069631131428671696
Pubmed

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

RFC2 MSH6 ATM

7.19e-0612113310783165
Pubmed

Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.

PRKG1 PRKG2

1.05e-052113225978317
Pubmed

Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain.

PRKG1 PRKG2

1.05e-05211328514791
Pubmed

Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I.

PRKG1 PRKG2

1.05e-052113210694248
Pubmed

Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity.

ANO1 AVIL

1.05e-052113224450308
Pubmed

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.

HFE TMPRSS6

1.05e-052113221355094
Pubmed

Expression of cGMP-dependent protein kinase, PKGIα, PKGIβ, and PKGII in malignant and benign breast tumors.

PRKG1 PRKG2

1.05e-052113222791569
Pubmed

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.

PRKG1 PRKG2

1.05e-05211328953039
Pubmed

Role of cGMP-kinase II in the control of renin secretion and renin expression.

PRKG1 PRKG2

1.05e-05211329788971
Pubmed

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.

HFE TMPRSS6

1.05e-052113219820699
Pubmed

Long-term potentiation in the hippocampal CA1 region of mice lacking cGMP-dependent kinases is normal and susceptible to inhibition of nitric oxide synthase.

PRKG1 PRKG2

1.05e-05211329870937
Pubmed

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.

ATM XRCC6

1.05e-052113223154512
Pubmed

Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.

HFE TMPRSS6

1.05e-052113223794717
Pubmed

The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease.

HFE TMPRSS6

1.05e-052113229194702
Pubmed

Type II, but not type I, cGMP-dependent protein kinase reverses bFGF-induced proliferation and migration of U251 human glioma cells.

PRKG1 PRKG2

1.05e-052113223404188
Pubmed

Cyclic GMP-dependent protein kinases: understanding in vivo functions by gene targeting.

PRKG1 PRKG2

1.05e-052113210454212
Pubmed

Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.

ATM DCLK1

1.05e-052113227876863
Pubmed

Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease.

HFE TMPRSS6

1.05e-052113230984307
Pubmed

Structural Basis of Analog Specificity in PKG I and II.

PRKG1 PRKG2

1.05e-052113228793191
Pubmed

Hereditary Ataxia Overview

OPHN1 POLR3A EEF2 PNPLA6 ATM

1.30e-0592113520301317
Pubmed

Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.

HFE TMPRSS6 BTN1A1

2.63e-0518113319084217
Pubmed

Genome-wide association study of the age of onset of childhood asthma.

IL5RA DCLK1

3.13e-053113222560479
Pubmed

Molecular analysis of homeostatic iron regulator, transmembrane protease serine-6, and BTB domain-containing protein-9 variants and iron parameters in blood donors.

HFE TMPRSS6

3.13e-053113233367529
Pubmed

Influence of functional polymorphisms in DNA repair genes of myelodysplastic syndrome.

ATM XRCC6

3.13e-053113227497341
Pubmed

Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6.

HFE TMPRSS6

3.13e-053113222244935
Pubmed

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

HFE TMPRSS6

3.13e-053113219820698
Pubmed

Regulation and role of myocyte cyclic GMP-dependent protein kinase-1.

PRKG1 PRKG2

3.13e-053113220498039
Pubmed

Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases.

PRKG1 PRKG2

3.13e-053113211278298
Pubmed

Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.

HFE TMPRSS6

3.13e-053113221785125
Pubmed

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.

ANO1 AVIL

3.13e-053113222634729
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DIS3L2 CAMK2G DHX57 RFC2 POLR3A PIK3R4 ACTR1B MSH6 EEF2 PNPLA6 LTN1 NFXL1 GNB2 DYNC1H1 XRCC6

3.32e-0513531131529467282
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

CLASP1 CAMK2G BDH2 NOSIP MSH6 SVIL TLN2 GNB2 XRCC6

3.77e-05498113936634849
Pubmed

Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.

CYP3A5 MSH6 ATM

5.64e-0523113316638864
Pubmed

MCM9 Is Required for Mammalian DNA Mismatch Repair.

RFC2 HORMAD1 MSH6

5.64e-0523113326300262
Pubmed

Proteomic data on the nuclear interactome of human MCM9.

RFC2 HORMAD1 MSH6

5.64e-0523113326870752
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

CAMK2G RFC2 POLR3A EIF3CL PIK3R4 NCOR1 MSH6 EEF2 NFXL1 MTR GNB2 HSDL1 DYNC1H1 XRCC6

5.91e-0512571131437317656
Pubmed

Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.

ATM XRCC6

6.25e-054113211158303
Pubmed

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.

HFE TMPRSS6

6.25e-054113223524968
Pubmed

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.

ATM XRCC6

6.25e-054113226941064
Pubmed

ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.

PRKG1 PRKG2

6.25e-054113215905169
Pubmed

Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers.

CPT2 RYR1

6.25e-054113220952238
Pubmed

Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/PP2A.

CAMK2G ANO1

6.25e-054113231461344
Pubmed

cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression.

PRKG1 PRKG2

6.25e-054113223755100
Pubmed

IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.

PRKG1 PRKG2

6.25e-054113216990611
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CAMK2G DHX57 PTPN21 PGAM2 OR10G7 OR10G4 NCOR1 EEF2 SUSD1 AVIL NFXL1 ATM ULK1 OR10G8 XRCC6

6.83e-0514421131535575683
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

PLK2 CLASP1 EIF3CL ACTR1B ZNF106 KCTD10 SVIL TLN2 ATM GNB2 DYNC1H1 XRCC6 ANAPC4

9.94e-0511551131320360068
Pubmed

The DNA sequence of human chromosome 7.

CYP3A5 LMBR1 SOSTDC1 RFC2 ITGB8 CRHR2 AP5Z1 NOBOX

1.01e-04441113812853948
Pubmed

Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.

ATM XRCC6

1.04e-045113228057860
Pubmed

Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair.

MSH6 XRCC6

1.04e-045113221075794
Pubmed

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.

ATM XRCC6

1.04e-045113211248063
Pubmed

A genome-wide association study of red blood cell traits using the electronic medical record.

HFE TMPRSS6

1.04e-045113220927387
Pubmed

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.

HFE TMPRSS6

1.04e-045113221208937
Pubmed

The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.

KCTD13 KCTD10

1.04e-045113232327643
Pubmed

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

HFE TMPRSS6

1.04e-045113223223430
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

DENND5B DIS3L2 CYP3A5 CAMK2G RALGAPB LMBR1 USP19 NOSIP MSH6 ZNF106 ARHGEF7 OR4K1 MTBP DEPDC5

1.05e-0413271131432694731
Pubmed

Defining the membrane proteome of NK cells.

CLASP1 CAMK2G POLR3A PIK3R4 ACTR1B NCOR1 EEF2 PNPLA6 PIGA NFXL1 GNB2 DYNC1H1 XRCC6

1.11e-0411681131319946888
Pubmed

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.

RFC2 MSH6 ATM

1.40e-0431113326095369
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

RFC2 MSH6 XRCC6

1.40e-0431113312171929
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

CHAF1B RFC2 EIF3CL MSH6 ULK1

1.48e-04153113526365490
Pubmed

Role of the translationally controlled tumor protein in DNA damage sensing and repair.

ATM XRCC6

1.56e-046113222451927
Pubmed

Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.

PRKG1 PRKG2

1.56e-046113212571245
Pubmed

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.

KCTD13 KCTD10

1.56e-046113228963344
Pubmed

DNA-PK suppresses a p53-independent apoptotic response to DNA damage.

ATM XRCC6

1.56e-046113219057578
Pubmed

Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse.

HFE BTN1A1

1.56e-046113211641716
Pubmed

Sequence variants in three loci influence monocyte counts and erythrocyte volume.

HFE TMPRSS6

1.56e-046113219853236
Pubmed

BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.

BTN2A2 BTN1A1

1.56e-046113220208008
Pubmed

SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation.

ATM XRCC6

1.56e-046113225299772
Pubmed

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

RFC2 MSH6 ATM XRCC6

1.67e-0484113419237606
Pubmed

Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.

CPT2 OPHN1 ULK1

1.70e-0433113322904094
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

CAMK2G ARHGEF7 TLN2 GNB2 DCLK1 DYNC1H1

1.77e-04251113627507650
Pubmed

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

ARHGEF7 GNB2 DYNC1H1 XRCC6 ANAPC4

1.87e-04161113532572027
Pubmed

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.

ATM XRCC6

2.17e-047113227829214
Pubmed

Synaptic, transcriptional and chromatin genes disrupted in autism.

RALGAPB DHX57

2.17e-047113225363760
Pubmed

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

ATM XRCC6

2.17e-047113219221393
Pubmed

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.

ATM XRCC6

2.17e-047113225818648
Pubmed

Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.

HFE TMPRSS6

2.17e-047113221149283
Pubmed

The cluster of BTN genes in the extended major histocompatibility complex.

BTN2A2 BTN1A1

2.17e-047113211170752
Pubmed

Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.

EIF3CL EEF2 XRCC6

2.21e-0436113316097034
Pubmed

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

CYP3A5 NCOR1 MSH6 ATM XRCC6

2.41e-04170113519064572
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

RALGAPB DHX57 POLR3A PIK3R4 ARHGEF7 NFXL1 MTR ULK1 HSDL1

2.80e-04650113938777146
Pubmed

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.

CAMK2G DEPDC5 ATM

2.80e-0439113322802532
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

GABRD CHAF1B PLK2 ITGB8 WDR19 PIK3R4 EEF2 SENP6 TLN2 ATM DCLK1 DYNC1H1 XRCC6

2.82e-0412851131335914814
Pubmed

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.

USP19 KCTD10

2.89e-048113231511519
Pubmed

Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation.

ARHGEF7 EPHB1

2.89e-048113217310244
Pubmed

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.

PIK3R4 ULK1

2.89e-048113223262492
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

DIS3L2 DPCD CPT2 USP19 MTR

3.39e-04183113531932471
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

CHAF1B DPCD DHX57 RFC2 POLR3A EIF3CL MSH6 DYNC1H1

3.62e-04533113830554943
Pubmed

BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.

CD163 XRCC6

3.71e-049113223555801
Pubmed

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.

ATM XRCC6

3.71e-049113216413926
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

UBR2 TLN2 DCLK1 DYNC1H1

3.78e-0410411349205841
Pubmed

Nucleolar proteome dynamics.

RFC2 NOSIP ZNF106 EEF2 ATM DYNC1H1 XRCC6

4.52e-04419113715635413
Pubmed

STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.

PIK3R4 ULK1

4.63e-0410113231696776
Pubmed

KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.

KCTD13 KCTD10

4.63e-0410113238489388
Pubmed

Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.

HORMAD1 ATM

4.63e-0410113219851446
GeneFamilyOlfactory receptors, family 10

OR10G7 OR10G4 OR10D4P OR10G8

1.79e-0466774157
GeneFamilyGelsolin/villins

AVIL SVIL

4.93e-048772950
GeneFamilyFibronectin type III domain containing

MYOM3 OBSCN PTPRT LIFR EPHB1

6.03e-04160775555
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTPN21 TLN2 PLEKHH2

1.26e-03507731293
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTN2A2 BTN1A1

1.81e-0315772458
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

DNAH3 PTPRT RYR1 SPATA16 AGBL1 DCLK1

3.59e-06163112619c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TASL GFRA2 CD163 RYR1 P2RY6 TNS4

3.85e-0616511262477b0f1a0ea26184cf3cc4a9ffcdfa825cbc615
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 GPR18 PNPLA6 AVIL AGBL1 DCLK1

5.96e-06178112609a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD163 OPHN1 P2RY6 AP5Z1 MTR WDSUB1

6.15e-0617911262c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD163 OPHN1 P2RY6 AP5Z1 MTR WDSUB1

6.15e-0617911266eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KSR2 ADAMTSL3 SUSD1 OR4K1 TLN2 SPATS2

6.35e-061801126023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KSR2 ADAMTSL3 SUSD1 TLN2 PRKG1 SPATS2

6.35e-061801126788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

OBSCN ZNF101 NOSIP TTC12 MTR ATM

7.20e-0618411265350b58aa9979631228835d11eb45ddf81d08bff
ToppCellTuft|World / Class top

PLK2 KCTD13 PNPLA6 AVIL UNC5D DCLK1

7.66e-061861126f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCellTuft-tuft-2|World / Class top

PLK2 KCTD13 PNPLA6 AVIL UNC5D DCLK1

7.90e-0618711264ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KSR2 ADAMTSL3 OPHN1 SUSD1 SPATS2 EPHB1

7.90e-061871126e3095455d2f255854f339f6b05fa87852af0700f
ToppCell(07)_Brush|World / shred by cell type and Timepoint

PLK2 KCTD13 GFRA2 AVIL UNC5D DCLK1

9.46e-0619311269af9d22a130ff97a9c37142a65e841b056d08640
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGB8 PTPRT LIFR PRKG1 CRISPLD1 EPHB1

1.06e-051971126f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ITGB8 CD163 RYR1 PRKG1 PRKG2

2.10e-051321125ddebc0b233fdbb73ceb70187945bbed8fd273f2a
ToppCellASK454-Epithelial-Type_2|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

HFE ITGB8 GFOD1 SPATS2 PLEKHH2

2.43e-051361125ff9a5e111993fdb3ac64c5ef269e3460ff994517
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ITGB8 CD163 RYR1 PRKG1 PRKG2

3.64e-051481125d5cace5605bff2bb8248fadb51f2dad7539930ba
ToppCelldroplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B HFE TASL RYR1 LIFR

7.03e-05170112529deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCelldroplet-Thymus-nan-21m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B HFE TASL RYR1 LIFR

7.03e-051701125dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HFE PLK2 GFOD1 P2RY6 TNS4

7.23e-051711125a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DPCD CD163 WDR19 TLN2 LTBR

7.23e-0517111257c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCellmild-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ITGB8 PNPLA6 DEPDC5 CRISPLD1 IL5RA

7.23e-0517111255c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCellPND07-28-samps-Myeloid-Macrophage-CD163+_Macrophage|PND07-28-samps / Age Group, Lineage, Cell class and subclass

HFE CD163 OPHN1 SUSD1 P2RY6

7.43e-0517211259a659442dc41bd2a4361a7e38a7ee37a39781667
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTPRT CRHR2 PRKG1 PLEKHH2 UNC5D

7.84e-051741125ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCelldroplet-Spleen-nan-3m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN PGAM2 OPHN1 LIFR PLEKHH2

8.06e-05175112521bc0e59a9509d38751ce6aad2325f341bc70eff
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD ANO1 RYR1 SVIL PLEKHH2

8.06e-05175112511f49f00e000cbc137e3540a6d6805cde21d96e6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD ANO1 RYR1 SVIL PLEKHH2

8.28e-05176112595d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCellICU-NoSEP-Myeloid-cDC1|ICU-NoSEP / Disease, Lineage and Cell Type

PLK2 GFRA2 P2RY6 MTERF2 SPATS2

8.50e-05177112533cd2c183ee8b597012efcbcae72131ac6beaf4e
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DENND5B PLK2 OBSCN SOSTDC1 CRISPLD1

8.73e-0517811250139b42494c1186390b12106dea7957e2b6717c2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD ANO1 RYR1 SVIL PLEKHH2

8.96e-0517911253b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCellNS-moderate-d_16-33-Myeloid-pDC|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DENND5B TASL SUSD1 P2RY6 EPHB1

9.20e-051801125144818e69613296cde43f29cb8c20899c670b319
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANO1 ADAMTSL3 CRHR2 ARHGEF7 PRKG1

9.44e-05181112533cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KSR2 ADAMTSL3 OPHN1 SUSD1 TLN2

9.69e-051821125f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 ADAMTSL3 GFRA2 CRHR2 PRKG1

1.02e-04184112555dde9c4eebac2a33788c1ff1d8fe312d150fad4
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 ADAMTSL3 GFRA2 CRHR2 PRKG1

1.02e-0418411257128a2be291544d3df3ed6c80f21ddda8437dcba
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 ADAMTSL3 GFRA2 CRHR2 PRKG1

1.02e-041841125d14238f7b0b55a4c8d7040bea854bd221a66ac30
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 ADAMTSL3 GFRA2 PRKG1 PLEKHH2

1.02e-041841125102b6f621a5b551e622f97b12d787c080b052a72
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KSR2 ADAMTSL3 SUSD1 MTR TLN2

1.05e-041851125d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

ADAMTSL3 ITGB8 TLN2 PRKG1 DCLK1

1.05e-041851125a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGB8 LIFR CFAP54 PLEKHH2 UNC5D

1.07e-0418611255c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANO1 CRHR2 PRKG1 PLEKHH2 UNC5D

1.07e-0418611250c477016c1b539b3086a8066c3c6443f08c222a3
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TASL HORMAD1 CD163 RYR1 P2RY6

1.10e-04187112523be50d81f4404a609dea821e1a66d221c0e0615
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGB8 PTPRT CFAP54 PLEKHH2 UNC5D

1.13e-04188112563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD CYP3A5 ADAMTSL3 PTPRT PRKG2

1.16e-041891125979b7fa947538aa7ca4a219263da2575869a2caa
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP3A5 OBSCN ANO1 ADAMTSL3 PRKG2

1.19e-0419011253b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

SOSTDC1 GFRA2 LIFR NCOR1 PLEKHH2

1.19e-04190112562a3ec1ae0829602b0569cc051210551644f1d46
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP3A5 OBSCN ANO1 ADAMTSL3 PRKG2

1.19e-041901125dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK2G ANO1 CRHR2 PRKG1 PRKG2

1.22e-0419111258e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GFRA2 LIFR PRKG1 PLEKHH2 EPHB1

1.22e-041911125fa380a8752de158974b2ae5e741573439719cc0d
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK2G ANO1 CRHR2 PRKG1 PRKG2

1.22e-04191112560bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD CYP3A5 ADAMTSL3 PTPRT PRKG2

1.25e-041921125bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP3A5 ANO1 ADAMTSL3 PTPRT UNC5D

1.28e-041931125294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP3A5 ANO1 ADAMTSL3 PTPRT UNC5D

1.28e-0419311253d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD CYP3A5 ADAMTSL3 PTPRT PRKG2

1.34e-04195112598ca9f3aa36211dde1e6f7f3817b9418c95e583e
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGB8 PTPRT TNS4 CRISPLD1 EPHB1

1.37e-041961125a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTSL3 TLN2 PRKG1 PLEKHH2 DCLK1

1.37e-041961125bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TASL GFRA2 CD163 RYR1 P2RY6

1.40e-0419711250a404b4494a2246d5a92299235056f0fda4d2b48
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Macroglial-Astroglia|6_mon / Sample Type, Dataset, Time_group, and Cell type.

BDH2 PGAM2 LIFR CRISPLD1 DCLK1

1.44e-041981125715ecad21f572b195ff3b78216b1a7b32bbb4ace
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

ADAMTSL3 TASL CD163 LIFR MSH6

1.44e-041981125af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-CD8+_T_naive|Bac-SEP / Disease, condition lineage and cell class

ZNF101 NOSIP MTR ATM PRKG2

1.44e-041981125a9a009e5eeb935232034635ad4a3c27d83c081ac
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Macroglial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

BDH2 PGAM2 LIFR CRISPLD1 DCLK1

1.44e-0419811259d03768f8b6c74e060c5f045508538f9b331f469
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

ADAMTSL3 TASL CD163 LIFR MSH6

1.44e-041981125ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

ADAMTSL3 TASL CD163 LIFR MSH6

1.44e-04198112562cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTSL3 LIFR PRKG1 PLEKHH2 DCLK1

1.44e-04198112521cf4d81386761d09d0f6829c01c198e5524176d
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-CD8+_T_naive|ICU-SEP / Disease, condition lineage and cell class

GPR18 NOSIP ACTR1B ATM PLEKHH2

1.47e-041991125ae5936ff37a333d66840dd1dfc59c4ce750625cd
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOSTDC1 ADAMTSL3 LIFR SVIL DCLK1

1.47e-0419911259846d6a31635fde759d55674631c11ab9270a603
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3|Neuronal / cells hierarchy compared to all cells using T-Statistic

GABRD ANO1 RYR1 SVIL PLEKHH2

1.51e-0420011252441a36d363b799a4692aa697f969cda056c2d60
ToppCellBronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

OBSCN ADAMTSL3 CRHR2 PRKG1 UNC5D

1.51e-04200112512326cc6f0af24bacba9493dc79e7c7347db2f41
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Macroglial-Astrocyte|6m / Sample Type, Dataset, Time_group, and Cell type.

BDH2 PGAM2 ITGB8 LIFR DCLK1

1.51e-0420011256ff22adb3007c3c9ef64a05c9dbc1d440bdaee1b
ToppCellwk_20-22-Mesenchymal-Fibroblast-Alveolar_fibro|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GABRD CYP3A5 GFRA2 LIFR PLEKHH2

1.51e-0420011250ed49c2177b58269ff7653db6be7d68633a5d34a
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANO1 SOSTDC1 ADAMTSL3 GFRA2 PRKG1

1.51e-042001125f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Macroglial|6m / Sample Type, Dataset, Time_group, and Cell type.

BDH2 PGAM2 ITGB8 LIFR DCLK1

1.51e-04200112542dc8ed66a021097e703eef2d756607396ca2f56
ToppCellBronchial-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CYP3A5 ADAMTSL3 LIFR CFAP54 CRISPLD1

1.51e-042001125b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANO1 SOSTDC1 SVIL PRKG1 CRISPLD1

1.51e-04200112508bf8c00eee6468215edb3611296bfc8784c4d56
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANO1 SOSTDC1 ADAMTSL3 GFRA2 PRKG1

1.51e-04200112567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ANO1 SOSTDC1 EEF2 SVIL PRKG1

1.51e-042001125dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GABRD ANO1 RYR1 SVIL PLEKHH2

1.51e-042001125c7bca638229bd4fd2414171e73fa949e36a10a92
ToppCellCOVID-19-COVID-19_Convalescent-Myeloid-cDC|COVID-19_Convalescent / Disease, condition lineage and cell class

PLK2 GFRA2 CD163 P2RY6 LTBR

1.51e-042001125ac9d7927863348a752444d2e80269a5eead943b7
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3--L2-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

GABRD ANO1 RYR1 SVIL PLEKHH2

1.51e-042001125d841dbe2297c3bf62f49bae5921662cd6a47e5c2
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ANO1 SOSTDC1 ADAMTSL3 GFRA2 PRKG1

1.51e-04200112577631c471cc5d453a749784f838cfa6408caf09b
ToppCellBronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CYP3A5 ADAMTSL3 LIFR CFAP54 CRISPLD1

1.51e-0420011257c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCellSubstantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TASL CD163 SUSD1 P2RY6

2.10e-041161124e93dd059d272e597a30e93f4c0504636f4e6c899
ToppCellSubstantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TASL CD163 SUSD1 P2RY6

2.10e-04116112427201cb805fe73b5ec51d7d585d047a4c043e8b0
ToppCellSubstantia_nigra-Hematopoietic-MACROPHAGE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TASL CD163 SUSD1 P2RY6

2.10e-041161124d3194bda2e3d5fd021e4015eed98c5888befe03d
ToppCellSubstantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TASL CD163 SUSD1 P2RY6

2.10e-0411611244e84b6f6661bb5ba0fe0de38a23bee9cc3727d94
ToppCellSubstantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TASL CD163 SUSD1 P2RY6

2.10e-04116112415d9a3d8c3cc1f6a1aead03cf84dc876c76b7063
ComputationalGenes in the cancer module 571.

GPR18 PTPN21 EPHB1

1.04e-0415683MODULE_571
DrugN'-hydroxyformamidine

CYP3A5 PRKG1 PRKG2

4.37e-0741103CID000012227
Diseasebody weight

DIS3L2 KSR2 ANO1 ADAMTSL3 PTPRT GPR139 NCOR1 BTN2A2 SUSD1 ARHGEF7 BTN1A1 SENP6 TLN2 PRKG2 ANAPC4 EPHB1

1.79e-05126111016EFO_0004338
DiseaseAdenocarcinoma of lung (disorder)

PLK2 KSR2 MSH6 ATM ULK1 XRCC6

1.26e-042061106C0152013
Diseasetotal iron binding capacity

HFE TMPRSS6 NOSIP EPHB1

2.11e-04781104EFO_0006334
Diseaseexecutive function measurement

DPCD GPR139 GFRA2 RYR1 POLR3A CRISPLD1 EPHB1

5.34e-043761107EFO_0009332
DiseaseGastric Adenocarcinoma

ATM DCLK1 EPHB1

6.38e-04451103C0278701
Diseaseneuroimaging measurement

HFE CAMK2G LRRC49 KSR2 PTPN21 ST7L ACTR1B NCOR1 ZNF106 TLN2 AGBL1 DCLK1

6.48e-04106911012EFO_0004346
Diseaseiron biomarker measurement

HFE TMPRSS6 BTN1A1

7.72e-04481103EFO_0004461
DiseaseCardiomyopathy, Familial Idiopathic

HFE CPT2 ATM

8.70e-04501103C1449563
Diseaseiron biomarker measurement, serum iron measurement

HFE TMPRSS6

8.87e-04121102EFO_0004461, EFO_0006332
Diseasesitting height ratio

ADAMTSL3 GFRA2 EPHB1

9.22e-04511103EFO_0007118
Diseasesmoking behavior, BMI-adjusted waist circumference

DIS3L2 ADAMTSL3 ITGB8 PRKG2

1.15e-031221104EFO_0004318, EFO_0007789
Diseaseacute lymphoblastic leukemia (is_implicated_in)

HFE CYP3A5 MTR

1.15e-03551103DOID:9952 (is_implicated_in)
DiseaseBMI-adjusted waist circumference, physical activity measurement

DIS3L2 ADAMTSL3 ITGB8 PRKG2

1.18e-031231104EFO_0007789, EFO_0008002
Diseaseiron biomarker measurement, transferrin saturation measurement

HFE TMPRSS6

1.22e-03141102EFO_0004461, EFO_0006333
Diseasetransferrin receptor protein 1 measurement

HFE TMPRSS6

1.22e-03141102EFO_0802142
DiseaseColorectal Carcinoma

DNAH3 OBSCN ADAMTSL3 PTPRT LIFR MSH6 TNS4 DCLK1 ANAPC4

1.27e-037021109C0009402
DiseaseIschemic stroke

KCTD13 ADAMTSL3 PTPRT ZNF106 AGBL1 EPHB1

1.38e-033241106HP_0002140
Diseaselateral ventricle volume change measurement

GPR139 GFRA2

1.40e-03151102EFO_0021502
Diseasecortical surface area measurement

ST7L ADAMTSL3 ITGB8 NOSIP NCOR1 ZNF106 SPATA16 TLN2 PRKG1 AGBL1 DCLK1 XRCC6 EPHB1

1.51e-03134511013EFO_0010736
Diseaseliver fat measurement, liver disease biomarker

HFE TMPRSS6

1.60e-03161102EFO_0006845, EFO_0010821
Diseasetransferrin saturation measurement

HFE TMPRSS6

1.60e-03161102EFO_0006333
Diseaselifestyle measurement, anxiety disorder measurement

PLK2 CFAP54 ILDR1 UNC5D

1.76e-031371104EFO_0007795, EFO_0010724
Diseaseserum hepcidin measurement

HFE TMPRSS6

2.03e-03181102EFO_0004504
Diseasemigraine disorder

KSR2 GFRA2 ZNF106 SVIL PRKG1 AGBL1

2.24e-033571106MONDO_0005277
Diseaseiron biomarker measurement, ferritin measurement

HFE TMPRSS6

2.26e-03191102EFO_0004459, EFO_0004461
Diseaseiron biomarker measurement, transferrin measurement

HFE TMPRSS6

2.50e-03201102EFO_0004461, EFO_0006341
DiseaseLiver carcinoma

GABRD CHAF1B CD163 LIFR MTBP DEPDC5 ATM

2.95e-035071107C2239176
Diseaseanxiety disorder (implicated_via_orthology)

CYP3A5 NCOR1

3.03e-03221102DOID:2030 (implicated_via_orthology)
Diseasediet measurement, fasting blood insulin measurement

ARHGEF7 AGBL1

3.03e-03221102EFO_0004466, EFO_0008111
Diseasediet measurement, HOMA-IR

ARHGEF7 AGBL1

3.31e-03231102EFO_0004501, EFO_0008111
Diseasespermatogenic failure (is_implicated_in)

PDHA2 WDR19

3.31e-03231102DOID:0111910 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
RKIAEVCCTSIVYAT

KCTD13

231

Q8WZ19
YRRCVSSVASEPRKL

DCAF17

71

Q5H9S7
RKIAEVCCTSIVYAT

KCTD10

221

Q9H3F6
LISSEYSRAKALVCV

CFAP54

1851

Q96N23
DCYVILSTRRVASLL

AVIL

41

O75366
ATTEKVRRSIYSCLD

ANAPC4

626

Q9UJX5
VIIRDTSAKNVSCYI

BTN1A1

206

Q13410
RTVLVKECYSVFTNR

CYP3A5

91

P20815
VFSCTTKKRTTVTIY

GPR18

46

Q14330
FEVVRTIKERACYLS

ACTR1B

211

P42025
VATLSCDRVLRVYSI

CHAF1B

186

Q13112
VIEAYCTSAKTRQTL

ARHGEF7

716

Q14155
IISATKYSRRLEKTC

AP5Z1

51

O43299
FGRTIIRSCTKLSYE

DIS3L2

481

Q8IYB7
EREYAVQTSLLCRVK

AGBL1

406

Q96MI9
TIRPASVYTKRCSEA

CPT2

501

P23786
LTLKYCVRRKTESID

OPHN1

316

O60890
EVTCQIRKKTRTLYR

NOBOX

266

O60393
EREAKFYRVVTCSLL

LTN1

216

O94822
TRSERYVCAVTRDSL

NOSIP

216

Q9Y314
QTEKSCYVLLAVISR

OVOS1

981

Q6IE37
RLKKSLVSTCAYITQ

DEPDC5

116

O75140
LVAISIVCSRKRAYS

EPHB1

556

P54762
YSVKTSRRVCICLAT

OR5M11

131

Q96RB7
VSCVRQLEVVKSSSY

PNPLA6

1206

Q8IY17
RSAYTPALKTVACRT

ESPNL

751

Q6ZVH7
SYVSIVCSILRIRTS

OR10G7

216

Q8NGN6
YTCIGISISKIRSAE

OR10D4P

216

Q8NGN7
SYVSIVCSILRIRTS

OR10G4

216

Q8NGN3
ITSLYVECRKITTAD

NFXL1

741

Q6ZNB6
IYTTCLRVVRTTFER

GRXCR1

141

A8MXD5
KSRLECEITTYRSLL

KRT39

386

Q6A163
ILYNCTRTATVKTLV

PRKG1

171

Q13976
VTTLCLVRKFTSAVR

LMBR1

441

Q8WVP7
AIITSLCKGRTLYSV

KSR2

736

Q6VAB6
ECVERSTAREYALKI

DCLK1

406

O15075
ISYTIILIGVRCRSS

OR4K1

216

Q8NGD4
TERYVTLFASIILKC

ILDR1

31

Q86SU0
TAIVMTYSTERLRKC

CRHR2

211

Q13324
YSDRLSLERQKLTVC

LRRC49

91

Q8IUZ0
CSIYSLKTREGNVRV

GNB2

121

P62879
VILYSIRITSTVACD

GABRD

151

O14764
RSTIVYEILKRTTCT

ANO1

246

Q5XXA6
VTSSVTTLRCRALNY

HFE

216

Q30201
SYVSIVCSILRIRTS

OR10G8

216

Q8NGN5
REICRIITKGTQTYS

MSH6

511

P52701
ILYNCTRTASVKAIT

PRKG2

236

Q13237
SAADCVRIYLTVARK

PLEKHH2

1331

Q8IVE3
TRTVEKLYKCSVDIR

MTERF2

46

Q49AM1
DTAQRSVSKYRCVIR

PTPRT

256

O14522
RTRRYTVSSKSCLVA

PTPN21

11

Q16825
ICKPRRDSRTDTVSY

OBSCN

5931

Q5VST9
KLILQSVCTRAVTYR

ITGB8

731

P26012
IYAKDRTDRIRTCAI

EIF3CL

556

B5ME19
RNTETRKRKLTICTY

ATM

2741

Q13315
DYETRITESKCVTIL

IL5RA

76

Q01344
KIVATYRLCSEQLSS

DNAH3

1581

Q8TD57
KLRSSYISICNREIS

GFRA2

176

O00451
RVIGTRVYSDLSSIC

CRISPLD1

431

Q9H336
LESVKSSATRLLYCT

DHX57

631

Q6P158
YSVSVDQKERCIIVR

DPCD

116

Q9BVM2
ISRDTLYVSKSICLI

DENND5B

181

Q6ZUT9
LIESVRTYERTCEKV

DYNC1H1

781

Q14204
QESRTCRKSIYLSTE

KRBOX4

121

Q5JUW0
CRKSIYLSTEFDSVR

KRBOX4

126

Q5JUW0
RCITIKSTAISLFYE

EEF2

66

P13639
KSITVICDFYSLIRL

HSDL1

36

Q3SXM5
KRLLAVSVSCITYLR

HORMAD1

31

Q86X24
RKVIVSVYITCFLTS

GPR139

146

Q6DWJ6
VIIRDKYVRNVSCSV

BTN2A2

211

Q8WVV5
VCSRYTEIRLVNGKT

CD163

576

Q86VB7
CSVYTTKSPRERAIL

RYR1

3216

P21817
SVVRRCVKKTSTQEY

CAMK2G

26

Q13555
RSRSCYQLEKTSIKI

LIFR

86

P42702
RLIRYETQTTCTRES

MTBP

681

Q96DY7
ICTSRRALTRTAVYT

P2RY6

51

Q15077
VCYTRGLSVRSILAE

PDHA2

121

P29803
TLIQTKRELGCRATY

SVIL

1501

O95425
LYALCVVDTIKRSSQ

GFOD1

341

Q9NXC2
EFDICYTSVLKRAIR

PGAM2

51

P15259
LEVEKRSVQCLYTSS

NCOR1

1871

O75376
ATETDTKIRVCTRAY

MTR

506

Q99707
AETVRYSICTSKLRV

POLR3A

1146

O14802
VASFIETKLVTCYLR

SPATA16

226

Q9BXB7
ACSTRIAYLTSLLEV

WDR19

356

Q8NEZ3
VVNRCVYSTTKAAVI

BDH2

141

Q9BUT1
RKASVFCLVAIYSVI

CLASP1

1481

Q7Z460
IICVSYTSKENTVLR

PIGA

181

P37287
STYQIRITTCKTELQ

PIK3R4

931

Q99570
CIQSVYISKIISSDR

XRCC6

66

P12956
QRCTVSLARYRVVVK

SPATS2

246

Q86XZ4
VYVKEICRDTSRVLF

USP19

301

O94966
LDIKYIEVTSARSRC

TNS4

146

Q8IZW8
VDETQVRSLYVSCKS

TASL

46

Q9HAI6
KRGSDYCIILRITSE

SUSD1

686

Q6UWL2
RLVACTRTYEESIKG

SENP6

591

Q9GZR1
ICYTAALLKTRTVSE

ST7L

366

Q8TDW4
IQSRCAVLRYTKLTD

RFC2

181

P35250
IVAKRRSLSATVVVY

UNC5D

236

Q6UXZ4
GDRKRAISSVCTYIV

RALGAPB

801

Q86X10
VQVGCRELRSTKYIS

SOSTDC1

71

Q6X4U4
TYVSAKCSRIRDTVC

LTBR

66

P36941
YTLVVTCRSLRAVAS

UTS2R

71

Q9UKP6
SYKCREIVRAFTVSS

ZNF101

196

Q8IZC7
YTKRELIECARAVTE

TLN2

1946

Q9Y4G6
ETASRYAIKILAICT

TTC12

576

Q9H892
ETTNLKETYRCIREA

PLK2

281

Q9NYY3
ATCSLDKTIRLYSLR

WDSUB1

26

Q8N9V3
CSLVDYVSLRKVIIT

TRIM64C

166

A6NLI5
VETIRYCVSQEKVSI

UBR2

596

Q8IWV8
TCSADKTVRVYNLVS

ZNF106

1546

Q9H2Y7
VRRLNELYKASVVSC

ULK1

936

O75385
LEKRLITSVYGCSRQ

TMPRSS6

281

Q8IU80
TVYITKRTEVINILC

ADAMTSL3

1201

P82987
ILYTDRQASLKVSCT

MYOM3

321

Q5VTT5