Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	MST1R NTRK1 NTRK2 LTK	1.22e-04	65	78	4	GO:0004714
GeneOntologyMolecularFunction	neurotrophin receptor activity	NTRK1 NTRK2	1.49e-04	5	78	2	GO:0005030
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	MST1R NTRK1 NTRK2 LTK	3.43e-04	85	78	4	GO:0019199
GeneOntologyBiologicalProcess	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	MST1R RAMP3 NTRK1 NTRK2 SEMA5A LTK PLXNB1	1.53e-05	217	76	7	GO:0051897
GeneOntologyCellularComponent	receptor complex	GABRE MST1R IL12RB1 RAMP3 RNF31 NTRK1 NTRK2 PTPRQ LTK ADGRV1 PLXNB1	8.83e-06	581	77	11	GO:0043235
GeneOntologyCellularComponent	sperm cytoplasmic droplet	IFT172 NME8	1.33e-04	5	77	2	GO:0097598
GeneOntologyCellularComponent	cell surface	CFH MST1R IL12RB1 ANTXRL RAMP3 ADAM20 LPA NTRK1 NTRK2 ADGRV1 PTPRT ADGRA3 HSP90AA1	1.94e-04	1111	77	13	GO:0009986
MousePheno	abnormal vibrissae reflex	NTRK1 NTRK2	1.75e-05	2	59	2	MP:0001490
Domain	Tyr_kinase_rcpt_2_CS	NTRK1 NTRK2 LTK	1.00e-05	11	75	3	IPR002011
Domain	RECEPTOR_TYR_KIN_II	NTRK1 NTRK2 LTK	1.33e-05	12	75	3	PS00239
Domain	TPKR_C2	NTRK1 NTRK2	4.76e-05	3	75	2	PF16920
Domain	Tyr_kinase_NGF_rcpt	NTRK1 NTRK2	4.76e-05	3	75	2	IPR020777
Domain	NTRK_C2	NTRK1 NTRK2	4.76e-05	3	75	2	IPR031635
Domain	Liprin	PPFIA1 PPFIA3	2.36e-04	6	75	2	IPR029515
Domain	Sema	MST1R SEMA5A PLXNB1	2.58e-04	31	75	3	SM00630
Domain	Semap_dom	MST1R SEMA5A PLXNB1	2.58e-04	31	75	3	IPR001627
Domain	Sema	MST1R SEMA5A PLXNB1	2.58e-04	31	75	3	PF01403
Domain	SEMA	MST1R SEMA5A PLXNB1	2.58e-04	31	75	3	PS51004
Domain	PSI	MST1R SEMA5A PLXNB1	2.84e-04	32	75	3	PF01437
Domain	Plexin_repeat	MST1R SEMA5A PLXNB1	2.84e-04	32	75	3	IPR002165
Domain	-	MST1R IL12RB1 ANTXRL MXRA5 NTRK1 NTRK2 PTPRT PLXNB1 ADGRA3 TGM5	3.07e-04	663	75	10	2.60.40.10
Domain	TyrKc	MST1R NTRK1 NTRK2 LTK	4.33e-04	88	75	4	SM00219
Domain	Tyr_kinase_cat_dom	MST1R NTRK1 NTRK2 LTK	4.33e-04	88	75	4	IPR020635
Domain	ResIII	ERCC3 DHX58	4.39e-04	8	75	2	PF04851
Domain	Helicase/UvrB_N	ERCC3 DHX58	4.39e-04	8	75	2	IPR006935
Domain	Cys-rich_flank_reg_C	MXRA5 NTRK1 NTRK2 ADGRA3	4.72e-04	90	75	4	IPR000483
Domain	LRRCT	MXRA5 NTRK1 NTRK2 ADGRA3	4.72e-04	90	75	4	SM00082
Domain	Ig-like_fold	MST1R IL12RB1 ANTXRL MXRA5 NTRK1 NTRK2 PTPRT PLXNB1 ADGRA3 TGM5	5.04e-04	706	75	10	IPR013783
Domain	PROTEIN_KINASE_TYR	MST1R NTRK1 NTRK2 LTK	6.27e-04	97	75	4	PS00109
Domain	Tyr_kinase_AS	MST1R NTRK1 NTRK2 LTK	6.27e-04	97	75	4	IPR008266
Domain	PSI	MST1R SEMA5A PLXNB1	7.32e-04	44	75	3	IPR016201
Domain	PSI	MST1R SEMA5A PLXNB1	8.34e-04	46	75	3	SM00423
Domain	Pkinase_Tyr	MST1R NTRK1 NTRK2 LTK	1.81e-03	129	75	4	PF07714
Domain	-	MST1R IFT172 SEMA5A PLXNB1 HIRA WDR72	2.20e-03	333	75	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	MST1R IFT172 SEMA5A PLXNB1 HIRA WDR72	2.27e-03	335	75	6	IPR015943
Domain	Ser-Thr/Tyr_kinase_cat_dom	MST1R NTRK1 NTRK2 LTK	2.31e-03	138	75	4	IPR001245
Domain	-	SERGEF TECPR1	3.49e-03	22	75	2	2.130.10.30
Domain	RCC1/BLIP-II	SERGEF TECPR1	3.81e-03	23	75	2	IPR009091
Domain	tRNA-bd_arm	PPFIA3 VARS1	4.15e-03	24	75	2	IPR010978
Domain	Protein_kinase_ATP_BS	MST1R NTRK1 NTRK2 MINK1 CILK1 LTK	4.16e-03	379	75	6	IPR017441
Domain	LRR_8	MXRA5 NTRK1 NTRK2 ADGRA3	4.98e-03	171	75	4	PF13855
Domain	IPT	MST1R PLXNB1	5.23e-03	27	75	2	SM00429
Pubmed	The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.	NTRK1 NTRK2 LTK	9.38e-07	9	79	3	12237455
Pubmed	Genetic modifiers of EGFR dependence in non-small cell lung cancer.	MST1R NTRK1 NTRK2	9.38e-07	9	79	3	25512530
Pubmed	trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.	NTRK1 NTRK2	5.09e-06	2	79	2	2555172
Pubmed	Primary and Metastatic Melanoma With NTRK Fusions.	NTRK1 NTRK2	5.09e-06	2	79	2	29683819
Pubmed	The crystal structures of TrkA and TrkB suggest key regions for achieving selective inhibition.	NTRK1 NTRK2	5.09e-06	2	79	2	22902478
Pubmed	NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases.	NTRK1 NTRK2	5.09e-06	2	79	2	31792356
Pubmed	Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas.	NTRK1 NTRK2	5.09e-06	2	79	2	15637590
Pubmed	Immunohistochemical localization of tyrosine receptor kinases A and B in endometriosis-associated ovarian cancer.	NTRK1 NTRK2	5.09e-06	2	79	2	19635108
Pubmed	Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ.	PTPRQ ADGRV1	5.09e-06	2	79	2	22357859
Pubmed	Neurotrophins and the thymus: morphological analysis of mice carrying a non-functional mutation on the Trka and Trkb genes.	NTRK1 NTRK2	5.09e-06	2	79	2	15372954
Pubmed	Fighting in the aged male mouse increases the expression of TrkA and TrkB in the subventricular zone and in the hippocampus.	NTRK1 NTRK2	5.09e-06	2	79	2	15639186
Pubmed	Antidepressant Imipramine Protects Bupivacaine-Induced Neurotoxicity in Dorsal Root Ganglion Neurons Through Coactivation of TrkA and TrkB.	NTRK1 NTRK2	5.09e-06	2	79	2	28398601
Pubmed	Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells.	NTRK1 NTRK2	5.09e-06	2	79	2	18678285
Pubmed	Tropomyosin-Related Kinase B (TrkB) Regulates Neurite Outgrowth via a Novel Interaction with Suppressor of Cytokine Signalling 2 (SOCS2).	NTRK1 NTRK2	1.53e-05	3	79	2	29881947
Pubmed	Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival.	NTRK1 NTRK2	1.53e-05	3	79	2	31071716
Pubmed	Survival of inner ear sensory neurons in trk mutant mice.	NTRK1 NTRK2	1.53e-05	3	79	2	9232598
Pubmed	Gangliosides activate Trk receptors by inducing the release of neurotrophins.	NTRK1 NTRK2	1.53e-05	3	79	2	12388556
Pubmed	Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.	NTRK1 NTRK2	1.53e-05	3	79	2	10388563
Pubmed	Dimerization of the Trk receptors in the plasma membrane: effects of their cognate ligands.	NTRK1 NTRK2	1.53e-05	3	79	2	30366959
Pubmed	Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice.	NTRK1 NTRK2	1.53e-05	3	79	2	8994044
Pubmed	TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations.	NTRK1 NTRK2	1.53e-05	3	79	2	31871300
Pubmed	The Effects of IGF-1 on Trk Expressing DRG Neurons with HIV-gp120- Induced Neurotoxicity.	NTRK1 NTRK2	1.53e-05	3	79	2	26652865
Pubmed	Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.	TRIM73 TRIM74	1.53e-05	3	79	2	26196062
Pubmed	Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC.	NTRK1 NTRK2	1.53e-05	3	79	2	10674466
Pubmed	The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion.	NTRK1 NTRK2	1.53e-05	3	79	2	15530548
Pubmed	The studies on the correlation for gene expression of tyrosine-kinase receptors and vascular endothelial growth factor in human neuroblastomas.	NTRK1 NTRK2	1.53e-05	3	79	2	20186105
Pubmed	Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study.	NTRK1 NTRK2	1.53e-05	3	79	2	21728718
Pubmed	Neurotrophin actions during the development of the peripheral nervous system.	NTRK1 NTRK2	1.53e-05	3	79	2	10383116
Pubmed	Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions.	NTRK1 NTRK2	1.53e-05	3	79	2	28719467
Pubmed	Sympathetic neuroblasts undergo a developmental switch in trophic dependence.	NTRK1 NTRK2	1.53e-05	3	79	2	8187631
Pubmed	Developmental dependency of Merkel endings on trks in the palate.	NTRK1 NTRK2	1.53e-05	3	79	2	11295244
Pubmed	DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma.	NTRK1 NTRK2	1.53e-05	3	79	2	21295543
Pubmed	TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons.	NTRK1 NTRK2	1.53e-05	3	79	2	8918886
Pubmed	Trk receptor expression and inhibition in neuroblastomas.	NTRK1 NTRK2	1.53e-05	3	79	2	19417027
Pubmed	A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.	NTRK1 NTRK2	1.53e-05	3	79	2	20133810
Pubmed	Prognostic value of tropomyosin-related kinases A, B, and C in gastric cancer.	NTRK1 NTRK2	1.53e-05	3	79	2	26459250
Pubmed	A chemical-genetic approach to studying neurotrophin signaling.	NTRK1 NTRK2	1.53e-05	3	79	2	15820690
Pubmed	The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas.	NTRK1 NTRK2	1.53e-05	3	79	2	16862449
Pubmed	Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.	NTRK1 NTRK2	1.53e-05	3	79	2	7823156
Pubmed	Crystal Structures of Neurotrophin Receptors Kinase Domain.	NTRK1 NTRK2	1.53e-05	3	79	2	28215291
Pubmed	Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons.	NTRK1 NTRK2	1.53e-05	3	79	2	8575307
Pubmed	The effect of P75 on Trk receptors in neuroblastomas.	NTRK1 NTRK2	1.53e-05	3	79	2	21419569
Pubmed	ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research.	NTRK1 NTRK2	1.53e-05	3	79	2	31268127
Pubmed	NTRK fusion analysis reveals enrichment in Middle Eastern BRAF wild-type PTC.	NTRK1 NTRK2	1.53e-05	3	79	2	33524004
Pubmed	The trk family of tyrosine protein kinase receptors.	NTRK1 NTRK2	1.53e-05	3	79	2	1751544
Pubmed	TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.	TRIM73 TRIM74	1.53e-05	3	79	2	22872646
Pubmed	Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer.	NTRK1 NTRK2	1.53e-05	3	79	2	24801982
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	TRIM73 NTRK1 NTRK2 MINK1 CILK1 HSP90AA1 TRIM74	2.27e-05	372	79	7	22939624
Pubmed	An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells.	NTRK1 NTRK2	3.05e-05	4	79	2	14706643
Pubmed	Identification of a consensus site for TRAF6/p62 polyubiquitination.	NTRK1 NTRK2	3.05e-05	4	79	2	18457658
Pubmed	Neurotrophin receptors: a window into neuronal differentiation.	NTRK1 NTRK2	3.05e-05	4	79	2	1327010
Pubmed	The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles.	NTRK1 NTRK2	3.05e-05	4	79	2	24569481
Pubmed	Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.	NTRK1 NTRK2	3.05e-05	4	79	2	9927421
Pubmed	A novel group of spindle cell tumors defined by S100 and CD34 co-expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes.	NTRK1 NTRK2	3.05e-05	4	79	2	30276917
Pubmed	Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling.	NTRK1 NTRK2	3.05e-05	4	79	2	12471037
Pubmed	Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma.	NTRK1 NTRK2	3.05e-05	4	79	2	19386345
Pubmed	p75 and TrkC neurotrophin receptors demonstrate a different immunoreactivity profile in comparison to TrkA and TrkB receptors in human normal pituitary gland and adenomas.	NTRK1 NTRK2	3.05e-05	4	79	2	18319596
Pubmed	Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons.	NTRK1 NTRK2	3.05e-05	4	79	2	12532410
Pubmed	Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC.	NTRK1 NTRK2	3.05e-05	4	79	2	8621424
Pubmed	Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering.	NTRK1 NTRK2	3.05e-05	4	79	2	32574560
Pubmed	Neurotrophin receptors TrkA and TrkB in retinoblastoma are differentially expressed depending on cellular differentiation.	NTRK1 NTRK2	3.05e-05	4	79	2	19816090
Pubmed	Cis- and trans-acting gene regulation is associated with osteoarthritis.	TM2D3 NME8	3.05e-05	4	79	2	16642435
Pubmed	TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.	NTRK1 NTRK2	3.05e-05	4	79	2	8815902
Pubmed	Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5.	NTRK1 NTRK2	3.05e-05	4	79	2	11738045
Pubmed	N-acetylserotonin activates TrkB receptor in a circadian rhythm.	NTRK1 NTRK2	3.05e-05	4	79	2	20133677
Pubmed	The roles played by the MYCN, Trk, and ALK genes in neuroblastoma and neural development.	NTRK1 NTRK2	3.05e-05	4	79	2	30848386
Pubmed	NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary.	NTRK1 NTRK2	3.05e-05	4	79	2	19357131
Pubmed	Ubiquitin Regulation of Trk Receptor Trafficking and Degradation.	NTRK1 NTRK2	3.05e-05	4	79	2	29911254
Pubmed	The dependence receptor TrkC regulates the number of sensory neurons during DRG development.	NTRK1 NTRK2	3.05e-05	4	79	2	30071216
Pubmed	Differential expression of neurotrophin receptors during renal development.	NTRK1 NTRK2	3.05e-05	4	79	2	8306895
Pubmed	Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.	NTRK1 NTRK2	3.05e-05	4	79	2	7991545
Pubmed	Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.	NTRK1 HSP90AA1	3.05e-05	4	79	2	20663926
Pubmed	Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.	NTRK1 NTRK2	3.05e-05	4	79	2	20811452
Pubmed	Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.	NTRK1 NTRK2	3.05e-05	4	79	2	16037097
Pubmed	Neurotrophin receptors expression and JNK pathway activation in human astrocytomas.	NTRK1 NTRK2	3.05e-05	4	79	2	17971243
Pubmed	Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease.	NTRK1 NTRK2	3.05e-05	4	79	2	25443284
Pubmed	A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching.	NTRK1 NTRK2	3.05e-05	4	79	2	23598414
Pubmed	Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc.	NTRK1 NTRK2	3.05e-05	4	79	2	18727839
Pubmed	Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.	NTRK1 NTRK2	3.05e-05	4	79	2	10490030
Pubmed	Treadmill rehabilitation treatment enhanced BDNF-TrkB but not NGF-TrkA signaling in a mouse intracerebral hemorrhage model.	NTRK1 NTRK2	3.05e-05	4	79	2	22999926
Pubmed	The protein tyrosine kinase family of the human genome.	MST1R NTRK1 NTRK2 LTK	3.95e-05	83	79	4	11114734
Pubmed	Promoting neurotrophic effects by GPCR ligands.	NTRK1 NTRK2	5.07e-05	5	79	2	16805430
Pubmed	Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.	TRIM73 TRIM74	5.07e-05	5	79	2	18398435
Pubmed	A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate.	PTGDR HSP90AA1	5.07e-05	5	79	2	24493589
Pubmed	Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling.	NTRK1 NTRK2	5.07e-05	5	79	2	8898237
Pubmed	SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population.	NTRK1 NTRK2	5.07e-05	5	79	2	18780967
Pubmed	Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.	NTRK1 NTRK2	5.07e-05	5	79	2	21102451
Pubmed	A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein.	NTRK1 NTRK2	5.07e-05	5	79	2	15167895
Pubmed	Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.	NTRK1 NTRK2	5.07e-05	5	79	2	15513915
Pubmed	Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC.	NTRK1 NTRK2	5.07e-05	5	79	2	10207144
Pubmed	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.	TRIM73 TRIM74	5.07e-05	5	79	2	20049703
Pubmed	N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.	NTRK1 NTRK2	5.07e-05	5	79	2	9507002
Pubmed	GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways.	NTRK1 NTRK2	5.07e-05	5	79	2	11251075
Pubmed	Plexin-B3 is a functional receptor for semaphorin 5A.	SEMA5A PLXNB1	5.07e-05	5	79	2	15218527
Pubmed	Expression of neurotrophin receptors by retinoinvasive uveal melanoma.	NTRK1 NTRK2	5.07e-05	5	79	2	22343487
Pubmed	Interplay between scatter factor receptors and B plexins controls invasive growth.	MST1R PLXNB1	5.07e-05	5	79	2	15184888
Pubmed	The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.	PPFIA1 PPFIA3	5.07e-05	5	79	2	19013515
Pubmed	Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development.	NTRK1 NTRK2	5.07e-05	5	79	2	23701859
Pubmed	The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death.	NTRK1 NTRK2	5.07e-05	5	79	2	9472042
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	NTRK1 NTRK2 ADGRA3	6.42e-05	34	79	3	18848646
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	MST1R NTRK1 NTRK2 LTK	6.00e-06	40	54	4	321
Coexpression	TIEN_INTESTINE_PROBIOTICS_2HR_DN	TCAF1 ERCC3 RESF1 PRCP PPFIA1	6.57e-06	89	77	5	M8916
Coexpression	LU_AGING_BRAIN_UP	CFH TCAF1 NTRK2 PPFIA1 RAPGEF4 PLXNB1 ADGRA3	1.25e-05	263	77	7	M5547
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_ASPN_POS_CHONDROCYTE	CFH MXRA5 SPOCK3 NTRK2 SERTAD4	2.49e-05	117	77	5	M45663
Coexpression	GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP	DHX58 STARD4 ALDH1A1 CRIP3 RTP4 TECPR1	2.69e-05	199	77	6	M9745
CoexpressionAtlas	kidney_adult_RenalCapsule_top-relative-expression-ranked_100	CFH UPK1B PTPRQ ALDH1A1 RTP4	1.60e-05	88	76	5	gudmap_kidney_adult_RenalCapsule_100
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 HYAL1 INPP5A NTRK2 RAPGEF4	1.06e-06	188	79	6	73f6ec915934154f435a376cb274b058ff7c5f35
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 HYAL1 INPP5A NTRK2 RAPGEF4	1.20e-06	192	79	6	c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 HYAL1 INPP5A NTRK2 RAPGEF4	1.24e-06	193	79	6	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	Basal_cells\|World / lung cells shred on cell class, cell subclass, sample id	CFH MXRA5 SPOCK3 PLCH2 SERTAD4 PLXNB1	1.39e-06	197	79	6	24360b660000bdfb999d58fbf4e29585a97e1785
ToppCell	Control-B_memory-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MST1R DGKK LTK SLC4A11 WDR72	4.41e-06	136	79	5	94f23bef50c0beb54ed39b1a4b340f7aec4e75cd
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH SPOCK3 LPA PLCH2 PTPRQ	9.16e-06	158	79	5	d78e7e52657dc094430291fec07e9c298be9e584
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPOCK3 FGFBP2 NTRK1 PTGDR TRIM74	1.13e-05	165	79	5	4d364e1aae41aea483d1311e5e8ef4fc33e30d5e
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	CFH SPOCK3 PLCH2 PTPRQ SEMA5A	1.34e-05	171	79	5	3965ced4be6db14265a90673502fceee425837ca
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CFH MXRA5 SPOCK3 UPK1B SERTAD4	1.46e-05	174	79	5	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	wk_08-11-Mesenchymal-Chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH MXRA5 SPOCK3 NTRK2 SERTAD4	1.54e-05	176	79	5	1af28b701c4598ce761f85adbd5d79e4918d265a
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH SPOCK3 PLCH2 PTPRQ SEMA5A	1.59e-05	177	79	5	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH SPOCK3 NTRK2 ADGRA3 TRIM74	1.63e-05	178	79	5	a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 HYAL1 NTRK2 RAPGEF4	1.72e-05	180	79	5	544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 HYAL1 NTRK2 RAPGEF4	1.72e-05	180	79	5	30cf3c7ee29694eaccb89bf8053a82037d5c9f1d
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH MXRA5 SPOCK3 NTRK2 SERTAD4	1.81e-05	182	79	5	0e52ba34e179d9bfaac7b49920b44c710b2b8dad
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH PLCH2 UPK1B PTPRQ SEMA5A	1.81e-05	182	79	5	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH PLCH2 UPK1B PTPRQ SEMA5A	1.81e-05	182	79	5	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	Control-Endothelial-Endothelial-Activated_Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 DHX58 SPOCK3 NTRK2 RAPGEF4	1.86e-05	183	79	5	e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CFH MST1R MXRA5 NTRK2 SERTAD4	2.07e-05	187	79	5	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	Control-Endothelial-Endothelial-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 HYAL1 NTRK2 RAPGEF4	2.07e-05	187	79	5	ea9d34bcd3bd1f36745846309ede349773de501a
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 INPP5A NTRK2 RAPGEF4	2.07e-05	187	79	5	f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH TCEA3 NTRK2 LTK PTGDR	2.07e-05	187	79	5	e1d6c1194476cf26969e405b0951796fed519f44
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 PRCP SPOCK3 NTRK2 RAPGEF4	2.17e-05	189	79	5	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 SPOCK3 INPP5A NTRK2 RAPGEF4	2.23e-05	190	79	5	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	BL-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH GABRE TCEA3 UPK1B ATP10B	2.23e-05	190	79	5	f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCell	15-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	CFH MXRA5 NTRK2 UPK1B PTPRQ	2.23e-05	190	79	5	b47472dc9fe6ed99c2365203a3d8a59879e74a70
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCEA3 ATP10B ALDH1A1 SLC4A11 WDR72	2.29e-05	191	79	5	e96184aee03175fd9f1da11fa2b89d95ba58b817
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFH MXRA5 FGFBP2 NTRK2 SERTAD4	2.29e-05	191	79	5	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	Basal_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CFH MXRA5 SPOCK3 PLCH2 PLXNB1	2.29e-05	191	79	5	a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell	LPS-IL1RA+antiTNF-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 PRCP SPOCK3 NTRK2 RAPGEF4	2.34e-05	192	79	5	04f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 PRCP SPOCK3 NTRK2 RAPGEF4	2.34e-05	192	79	5	c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFH MXRA5 SPOCK3 FGFBP2 SERTAD4	2.34e-05	192	79	5	3a6f2c255da46a0b0f5b657b0f56f3d7798ae85a
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ZBED6 FGFBP2 NTRK1 PTGDR NME8	2.40e-05	193	79	5	91a1c9b8390cbd881db8c49d8f34feca0d1067d6
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH MXRA5 RAPGEF4 SEMA5A WDR72	2.40e-05	193	79	5	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 PRCP SPOCK3 NTRK2 RAPGEF4	2.46e-05	194	79	5	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAMP3 PRCP SPOCK3 NTRK2 RAPGEF4	2.46e-05	194	79	5	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH SPOCK3 PLCH2 SEMA5A PTPRT	2.52e-05	195	79	5	6c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell	NS-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH TCEA3 UPK1B ATP10B SLC4A11	2.52e-05	195	79	5	b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCEA3 IFT172 NTRK2 ATP10B ALDH1A1	2.52e-05	195	79	5	b67d4f34cae729c18275486d3b20c9dd7d5cbe79
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH TCEA3 CILK1 PLA2G10 ATP10B	2.59e-05	196	79	5	47930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH SPOCK3 PLCH2 PTPRT SLC4A11	2.65e-05	197	79	5	107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCell	Biopsy_Other_PF-Epithelial-MUC5AC+_High\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ADAM20 UPK1B PLA2G10 ATP10B SLC4A11	2.72e-05	198	79	5	30e6177e216f66caddcd009fafef0e07369f4d8e
ToppCell	distal-Epithelial-Differentiating_Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LPA UPK1B ARL14 TGM5 WDR72	2.78e-05	199	79	5	a1b87c74fe3106ff8bf1c6ff4048d0c3d3fee7ba
ToppCell	distal-Epithelial-Differentiating_Basal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LPA UPK1B ARL14 TGM5 WDR72	2.78e-05	199	79	5	286d52f25120293620bdbfd62b832f08e118adf6
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MXRA5 UPK1B SERTAD4 ALDH1A1	2.78e-05	199	79	5	ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IL12RB1 ATP10B ADGRV1 SSPOP	7.04e-05	124	79	4	9f169fa17be1842a6bd83778ff30465a740edd5f
ToppCell	LPS_only-Hematopoietic_Mast-Mast_cells-Mast-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTRK1 ALDH1A1 RTP4 NME8	1.01e-04	136	79	4	82d7f90ef2a63a3137c331efd68c036cd0db3ac1
ToppCell	facs-Aorta-Heart-3m-Myeloid-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 DGKK SSPOP NME8	1.10e-04	139	79	4	22a769d5195ed761ef333ef542746e1ba617a698
ToppCell	facs-Aorta-Heart-3m-Myeloid-professional_antigen_presenting_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 DGKK SSPOP NME8	1.10e-04	139	79	4	292533e04178dd36d57377562077f9deb2cb9746
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FGFBP2 NTRK2 SSPOP RTP4	1.32e-04	146	79	4	cffa91d76606f74553d81150adbb23b003746316
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|390C / Donor, Lineage, Cell class and subclass (all cells)	FGFBP2 PTGDR SSPOP RTP4	1.47e-04	150	79	4	fdbfc8f743cf848978cf0488493f6df60be53982
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FGFBP2 NTRK2 SSPOP RTP4	1.58e-04	153	79	4	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFH SPOCK3 LPA PLCH2	1.62e-04	154	79	4	38d346402417960044ae999e61f0092b46f2b591
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CFH PTPRQ TGM5 SLC4A11	1.67e-04	155	79	4	90e629681a72baacc7981b82883866a487638dbc
ToppCell	droplet-Fat-Mat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G10 ATP10B PPFIA3 TGM5	1.71e-04	156	79	4	cfd7f56f3155db677684827607e9008e975dbe70
ToppCell	droplet-Fat-Mat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G10 ATP10B PPFIA3 TGM5	1.71e-04	156	79	4	0d79b4172896574b00faf00e87254f68d76f5512
ToppCell	droplet-Fat-Mat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G10 ATP10B PPFIA3 TGM5	1.71e-04	156	79	4	f09150aacb6121f913648ed3918f9cd4f22c61f2
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FGFBP2 PTGDR NME8 WDR72	1.71e-04	156	79	4	e6798d2b9c2c1fc6525c24f596f25aa85a375651
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_C\|367C / Donor, Lineage, Cell class and subclass (all cells)	FGFBP2 PTGDR NME8 WDR72	1.71e-04	156	79	4	a1b9e7621b646d354c2ccd850ce6a4fa9ff8a026
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RAMP3 SPOCK3 RAPGEF4 SEMA5A	1.75e-04	157	79	4	516903469756c5fabfdf56d7bd59b3bdd7b44e39
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH FGFBP2 DGKK PPFIA3	1.97e-04	162	79	4	f0a92c92c3a6cf9fa11fb279a584e7f328cb7d43
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CFH ZSCAN1 SPOCK3 TRIM74	1.97e-04	162	79	4	233011408f022647932c81ebab78f9813e3c6833
ToppCell	facs-Heart-RA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G10 ATP10B PPFIA3 ARL14	2.02e-04	163	79	4	13557be854878abc1bcdab909b49b8292d064145
ToppCell	facs-Heart-RA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G10 ATP10B PPFIA3 ARL14	2.02e-04	163	79	4	6c1d1646410e785886d2de103b4b12f73e91edff
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	INPP5A FGFBP2 PLA2G10 PTGDR	2.02e-04	163	79	4	6c4d4c55fc8a731acca13c1ba7287f238a9d81e0
ToppCell	severe_influenza-CD4+_CTL\|World / disease group, cell group and cell class (v2)	CFH GABRE IL12RB1 FGFBP2	2.16e-04	166	79	4	cdc3e200373718f26fe02ee516928097103f46e2
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RAMP3 PRCP HYAL1 RAPGEF4	2.16e-04	166	79	4	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FGFBP2 DGKK PTGDR HSP90AA1	2.27e-04	168	79	4	696b31bedbc7d40817a733e8c6ec2633404be619
ToppCell	facs-Large_Intestine-Proximal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTRK2 ALDH1A1 PPFIA3 ARL14	2.27e-04	168	79	4	23e0e1592d7400012d289adb10c7598285bae2e9
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPOCK3 UPK1B SERTAD4 ALDH1A1	2.32e-04	169	79	4	3f738fc56bbc70dc77c9ba41025631f8264cd2b3
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH NTRK1 SERTAD4 CRIP3	2.32e-04	169	79	4	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MXRA5 SERTAD4 SEMA5A	2.37e-04	170	79	4	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MXRA5 SERTAD4 SEMA5A	2.37e-04	170	79	4	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD16\|GI_small-bowel / Manually curated celltypes from each tissue	FGFBP2 DGKK PTGDR NME8	2.42e-04	171	79	4	1ee505b91f15191d294a5d491ecdf154c08b8622
ToppCell	normal-na-Lymphocytic_T-T4_em-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CFH RESF1 NTRK2 SEMA5A	2.42e-04	171	79	4	61318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCell	facs-Trachea-nan-24m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCH2 UPK1B PLXNB1 WDR72	2.42e-04	171	79	4	d2a10e94b0490120d1420b944302eb841f902c64
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D\|367C / Donor, Lineage, Cell class and subclass (all cells)	RNF31 FGFBP2 PLCH2 PTGDR	2.48e-04	172	79	4	6379ae0aca9007c3a8a87e3330908fc90961ad3f
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRCP IFT172 SEMA5A IRF2BPL	2.53e-04	173	79	4	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.4\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH ATP10B ALDH1A1 SLC4A11	2.53e-04	173	79	4	176b956e71d98e8275d698b39437fc326e5fe449
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Airway_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH MXRA5 NTRK2 SERTAD4	2.53e-04	173	79	4	b23b408acc29a667cce104429afef1a6cf2720a5
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte-3\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRE MST1R PLCH2 UPK1B	2.59e-04	174	79	4	76310c0af1d7df6a4de3816838b2ac2892f68746
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK\|GI_small-bowel / Manually curated celltypes from each tissue	FGFBP2 DGKK PTGDR NME8	2.59e-04	174	79	4	09b216f07cffd3ea2149ea95ffb5cd7219b3a98c
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-E\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	RAMP3 NTRK2 RAPGEF4 LTK	2.59e-04	174	79	4	4a1b67ce5ea353b3f81f59fa57da07668146afca
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	CFH ZSCAN1 ALDH1A1 SLC4A11	2.65e-04	175	79	4	af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|356C / Donor, Lineage, Cell class and subclass (all cells)	CFH ZSCAN1 ALDH1A1 SLC4A11	2.65e-04	175	79	4	4bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRQ ADGRV1 PTPRT WDR72	2.65e-04	175	79	4	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STARD4 LPA SEMA5A STAG3	2.70e-04	176	79	4	8b5c2fb7e5e551df658b1d5fc7f607a27bab00d5
ToppCell	metastatic_Brain-Fibroblasts-Undetermined\|metastatic_Brain / Location, Cell class and cell subclass	HYAL1 NTRK2 UPK1B PTGDR	2.76e-04	177	79	4	54f39be5d90363cfd44dea1a96ae06d3143aa795
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH SPOCK3 PTPRQ SEMA5A	2.76e-04	177	79	4	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	10x5'v1-week_17-19-Lymphocytic_NK-T_NK-mature_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	IL12RB1 FGFBP2 DGKK PTGDR	2.76e-04	177	79	4	0f2616a81f8fbede77c860b2126e3fa826672da3
ToppCell	(06)_Krt4/13+\|World / shred by cell type and Timepoint	UPK1B ATP10B ARL14 TGM5	2.82e-04	178	79	4	46efdf03aa1317bc600138e871509b995e773cce
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH SPOCK3 LPA PLXNB1	2.82e-04	178	79	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	wk_15-18-Mesenchymal-Mesothelial-intermediate_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH C13orf46 PTPRQ TGM5	2.88e-04	179	79	4	b1f085e4c8d65d5cdbfaf2db80343638abb08979
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GABRE ATP10B ADGRV1 SLC4A11	2.88e-04	179	79	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PLCH2 UPK1B SEMA5A PTPRT	2.88e-04	179	79	4	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	CFH SPOCK3 LPA PLCH2	2.88e-04	179	79	4	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MST1R SPOCK3 UPK1B PLA2G10	2.95e-04	180	79	4	3d95232b5785c705f41e01e3ffe0fa8dce1ff0a7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FGFBP2 SEMA5A PTGDR NME8	2.95e-04	180	79	4	557453b74d4a9cc95ed1c7b9a9a58e45eb02ed6a
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MST1R SPOCK3 UPK1B PLA2G10	2.95e-04	180	79	4	47e345359064dc8ceec982b062e47802e728b43f
ToppCell	368C-Endothelial_cells-Endothelial-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	RAMP3 HYAL1 NTRK2 RAPGEF4	2.95e-04	180	79	4	8ab16a0b9053bffc07b569a4f9e71749f56dde7e
Disease	response to selective serotonin reuptake inhibitor, body mass index	PLCH2 PTPRT	1.72e-04	8	74	2	EFO_0004340, EFO_0005658
Disease	glaucoma (implicated_via_orthology)	NTRK1 NTRK2	8.24e-04	17	74	2	DOID:1686 (implicated_via_orthology)
Disease	metabolically healthy obesity	CCDC179 RTP4	9.25e-04	18	74	2	EFO_0009382
Disease	Lewy Body Disease	NTRK1 NTRK2	1.39e-03	22	74	2	C0752347
Disease	Carcinoma of lung	MXRA5 NTRK2	1.52e-03	23	74	2	C0684249
Disease	cholesteryl ester 14:0 measurement	CFH CCDC179	2.09e-03	27	74	2	EFO_0010340
Disease	glaucoma (biomarker_via_orthology)	NTRK1 NTRK2	2.25e-03	28	74	2	DOID:1686 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PWMCCQSRDQGRYLS	ANTXRL	461	A6NF34
YVKCWTPDIMCGRVQ	ADAM20	551	O43506
AWIMTCCPGRSSYSV	ADGRA3	1056	Q8IWK6
VCWEPQAQGRMCALY	GSDMD	456	P57764
WMNVSAVGEPLYTCA	ADGRV1	2426	Q8WXG9
TVWVNCYGVVSAQCP	ALDH1A1	451	P00352
MRTVWGCYCENTDGL	ARL14	71	Q8N4G2
VCINGRWDPEVNCSM	CFH	791	P08603
CVICNSPTNPYWVME	ATP10B	1276	O94823
NCTEMEANVVGCYWP	RAMP3	71	O60896
QYCPGTWCFIQMVHE	PTGDR	176	Q13258
WVEGNMPVSSQCAVC	DGKK	401	Q5KSL6
ACPPEVYAIMRGCWQ	NTRK1	751	P04629
PCCIVTSTYGWTANM	HSP90AB3P	461	Q58FF7
VGMPAWYVAACRANV	PPFIA3	851	O75145
RGCPGPVYRIMTQCW	LTK	746	P29376
MIWDFSEPVCRGCVN	IRF2BPL	26	Q9H1B7
WYCPQCTAAMKRRGS	ING3	401	Q9NXR8
RCQTAMPQYGCVWCE	PLXNB1	1031	O43157
MPQYGCVWCEGERPR	PLXNB1	1036	O43157
GEQYMNTRCPAWCDR	INPP5A	336	Q14642
WCEYRGQPSMCQAFA	FGFBP2	71	Q9BYJ0
TLGWSYQACTEVVMP	PRCP	356	P42785
VGMPAWYVAACRANV	PPFIA1	891	Q13136
YFCMVPDCEGSTWQQ	GABRE	456	P78334
EWCEQQVPYMCPDYQ	KRT35	131	Q92764
RYSWQCVNQSVLCGP	PLA2G10	106	O15496
CMSGCPNCVWVEYAD	OXLD1	91	Q5BKU9
CSYMQWVPGSDVLVA	IFT172	526	Q9UG01
GDCMTVRQCNFTAWP	PTPRQ	2186	Q9UMZ3
AQFCMQYWPEKTSGC	PTPRT	1281	O14522
SCRNCGEVWGLQMIY	DHX58	611	Q96C10
MDPNVRWEYCNLTQC	LPA	1231	P08519
VRWEYCNLTQCPVME	LPA	1341	P08519
MSWTCPRCQQPVFFA	CRIP3	1	Q6Q6R5
RAQSMTYCIEWQPVG	IL12RB1	361	P42701
TLSCMLGRVYQSCWQ	PMCHL1	71	Q16048
EMQTSWVCCIPYSTR	C13orf46	191	A0A1B0GUA9
QMAVEFKCRCYPGWQ	HYAL1	411	Q12794
QCAEVWCPMSPEFYR	ERCC3	506	P19447
PCCIVTSTYGWTANM	HSP90AA1	596	P07900
ACVNCVRWSNSGMYL	HIRA	71	P54198
YRICCWKMVPGINDS	C5orf34	431	Q96MH7
PWQTLACCMEVANAV	POLRMT	891	O00411
MCLYCWDIEPSQVNP	CCDC179	1	H3BU77
WGEMPTSVAYICSNQ	MINK1	1251	Q8N4C8
QRCQKCSWSQYEMPE	RTP4	91	Q96DX8
PQWYVRCGEMAQAAS	VARS1	676	P26640
TYRQCCVGTELVDWM	RAPGEF4	231	Q8WZA2
GVRYQQSWLCIICTM	SLC4A11	191	Q8NBS3
CPIQQVACGWDFTIM	SERGEF	101	Q9UGK8
SEWTMCSQPCRGQTR	SSPOP	3416	A2VEC9
VEVNCTNPGTRYCWM	TCAF1	531	Q9Y4C2
GWLSMVYEGVPQCQC	RESF1	1176	Q9HCM1
CWPCMVAEVSRYLSQ	PRAMEF19	216	Q5SWL8
GEIIMQNNWCFPACS	SERTAD4	141	Q9NUC0
TMGSDYCPSEWRQVQ	TEX45	371	Q8NA69
CIGAQDPYCGWDVVM	SEMA5A	496	Q13591
NYSSPIDVWAVGCIM	CILK1	176	Q9UPZ9
MQYILNPICTWCVGQ	CLPP	136	Q16740
ENNCMRIYTTCQPSW	CLUL1	121	Q15846
RTCPQEVYELMLGCW	NTRK2	776	Q16620
CNSSPGWVCVMCNRT	RNF31	421	Q96EP0
VRCPMCWQVVDGSSS	TRIM74	51	Q86UV6
VIDVYQAWCGPCRAM	NME8	31	Q8N427
YSVPAWSCQMICGSG	ACAT2	81	Q9BWD1
RAICIEEIGCWMQSY	STAG3	321	Q9UJ98
VDMYAWVLQAGCRCV	PLCH2	356	O75038
GCVVEACAMPRWFTV	TECPR1	541	Q7Z6L1
PFQCADCGMVFTWVT	ZSCAN1	291	Q8NBB4
RSSQFPDWINCMCIV	WDR72	151	Q3MJ13
PMTTFVLCNECGNRW	TCEA3	331	O75764
QPVRYGQCWVFAAVM	TGM5	271	O43548
VGQCWCVDRYGNEVM	SPOCK3	356	Q9BQ16
DADYPWPRQCCVMNN	UPK1B	181	O75841
VAIQYLSCPMCSWQS	ZBED6	901	P86452
VRCPMCWQVVDGSSS	TRIM73	51	Q86UV7
CCVMRYTTAGQLWNI	STARD4	96	Q96DR4
YCPDSLYQVMQQCWE	MST1R	1311	Q04912
INMTCRFCWQLPETD	TM2D3	121	Q9BRN9
NLYLQGNPWTCDCEM	MXRA5	211	Q9NR99
EGCTYDRPCRWLQMA	EXD3	781	Q8N9H8