Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	axon guidance receptor activity	EPHB2 PTK7 HMCN2	8.59e-05	13	137	3	GO:0008046
GeneOntologyMolecularFunction	linear polyubiquitin binding	RNF31 IKBKG	1.40e-04	3	137	2	GO:1990450
GeneOntologyMolecularFunction	microtubule binding	SPAST BCL2L11 KIF26A KIF12 KIF24 ALMS1 CDK5RAP2 PSRC1 NIN	2.81e-04	308	137	9	GO:0008017
GeneOntologyCellularComponent	cell-cell junction	DCHS2 SYNM SIPA1L3 OBSCN LAMA3 PTK7 GJD3 TLN1 DLG2 TLN2 PLEKHA7 PCDH1 NOTCH1	1.63e-04	591	139	13	GO:0005911
GeneOntologyCellularComponent	LUBAC complex	RNF31 RBCK1	2.61e-04	4	139	2	GO:0071797
GeneOntologyCellularComponent	extracellular matrix	OLFML2B HAPLN4 LAMA3 EMILIN3 MUC5B TECTA MMP25 SSC5D HMCN2 GLG1 ANGPT4 ADAMTSL4 SOD3	4.43e-04	656	139	13	GO:0031012
GeneOntologyCellularComponent	spindle pole	SPAST CNTRL IKBKG ALMS1 CDK5RAP2 PSRC1 NIN	4.51e-04	205	139	7	GO:0000922
GeneOntologyCellularComponent	external encapsulating structure	OLFML2B HAPLN4 LAMA3 EMILIN3 MUC5B TECTA MMP25 SSC5D HMCN2 GLG1 ANGPT4 ADAMTSL4 SOD3	4.56e-04	658	139	13	GO:0030312
MousePheno	hypochlorhydria	TRIM73 TRIM50 TRIM74	1.90e-05	7	116	3	MP:0008001
Domain	Growth_fac_rcpt_	EPHB2 LAMA3 CUBN LRP1B GPR179 HMCN2 LRP1 NOTCH1	2.10e-05	156	138	8	IPR009030
Domain	-	TLN1 TLN2	5.42e-05	2	138	2	1.20.1420.10
Domain	VBS	TLN1 TLN2	5.42e-05	2	138	2	PF08913
Domain	Vinculin-bd_dom	TLN1 TLN2	5.42e-05	2	138	2	IPR015009
Domain	Talin_cent	TLN1 TLN2	5.42e-05	2	138	2	IPR015224
Domain	DUF5050	LRP1B LRP1	5.42e-05	2	138	2	IPR032485
Domain	Talin_middle	TLN1 TLN2	5.42e-05	2	138	2	PF09141
Domain	DUF5050	LRP1B LRP1	5.42e-05	2	138	2	PF16472
Domain	DH_1	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11	1.02e-04	63	138	5	PS00741
Domain	zf-RING_UBOX	TRIM73 RBCK1 TRIM50 TRIM74	1.11e-04	34	138	4	PF13445
Domain	Znf-RING_LisH	TRIM73 RBCK1 TRIM50 TRIM74	1.11e-04	34	138	4	IPR027370
Domain	RhoGEF	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11	1.47e-04	68	138	5	SM00325
Domain	Talin-1	TLN1 TLN2	1.62e-04	3	138	2	IPR015710
Domain	RhoGEF	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11	1.69e-04	70	138	5	PF00621
Domain	DH_2	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11	1.69e-04	70	138	5	PS50010
Domain	-	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11	1.80e-04	71	138	5	1.20.900.10
Domain	DH-domain	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11	1.80e-04	71	138	5	IPR000219
Domain	ZF_BBOX	TRIM73 TRIM21 RBCK1 TRIM50 TRIM74	3.16e-04	80	138	5	PS50119
Domain	ILWEQ_dom	TLN1 TLN2	3.22e-04	4	138	2	IPR002558
Domain	ILWEQ	TLN1 TLN2	3.22e-04	4	138	2	SM00307
Domain	FERM_f0	TLN1 TLN2	3.22e-04	4	138	2	PF16511
Domain	ILWEQ	TLN1 TLN2	3.22e-04	4	138	2	PD011820
Domain	-	TLN1 TLN2	3.22e-04	4	138	2	1.20.1410.10
Domain	I_LWEQ	TLN1 TLN2	3.22e-04	4	138	2	PF01608
Domain	I_LWEQ	TLN1 TLN2	3.22e-04	4	138	2	PS50945
Domain	ICAM	ICAM3 ICAM5	3.22e-04	4	138	2	IPR003988
Domain	FERM_f0	TLN1 TLN2	3.22e-04	4	138	2	IPR032425
Domain	Znf_B-box	TRIM73 TRIM21 RBCK1 TRIM50 TRIM74	3.34e-04	81	138	5	IPR000315
Domain	EGF_CA	CUBN LRP1B HMCN2 LRP1 NOTCH1	4.41e-04	86	138	5	PF07645
Domain	EGF-like_dom	ADAM21 LAMA3 CUBN TECTA LRP1B HMCN2 LRP1 NOTCH1	5.34e-04	249	138	8	IPR000742
Domain	ICAM_N	ICAM3 ICAM5	5.34e-04	5	138	2	PF03921
Domain	ICAM_N	ICAM3 ICAM5	5.34e-04	5	138	2	IPR013768
Domain	-	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11 SPTBN5 TLN1 TLN2 PLEKHA7 AGAP3	6.62e-04	391	138	10	2.30.29.30
Domain	EGF_Ca-bd_CS	CUBN LRP1B HMCN2 LRP1 NOTCH1	7.66e-04	97	138	5	IPR018097
Domain	ICAM_VCAM_N	ICAM3 ICAM5	7.97e-04	6	138	2	IPR003987
Domain	EGF_2	EPHB2 ADAM21 LAMA3 CUBN LRP1B HMCN2 LRP1 NOTCH1	8.02e-04	265	138	8	PS01186
Domain	EGF_CA	CUBN LRP1B HMCN2 LRP1 NOTCH1	8.40e-04	99	138	5	PS01187
Domain	ASX_HYDROXYL	CUBN LRP1B HMCN2 LRP1 NOTCH1	8.79e-04	100	138	5	PS00010
Domain	PH	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11 SPTBN5 PLEKHA7 AGAP3	1.09e-03	278	138	8	SM00233
Domain	Vinculin/catenin	TLN1 TLN2	1.11e-03	7	138	2	IPR006077
Domain	PH_DOMAIN	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11 SPTBN5 PLEKHA7 AGAP3	1.12e-03	279	138	8	PS50003
Domain	EGF-type_Asp/Asn_hydroxyl_site	CUBN LRP1B HMCN2 LRP1 NOTCH1	1.14e-03	106	138	5	IPR000152
Domain	PH_domain	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11 SPTBN5 PLEKHA7 AGAP3	1.14e-03	280	138	8	IPR001849
Domain	Spectrin_repeat	TRIO SPTBN5 PLEC	1.25e-03	29	138	3	IPR002017
Domain	PH_dom-like	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11 SPTBN5 TLN1 TLN2 PLEKHA7 AGAP3	1.27e-03	426	138	10	IPR011993
Domain	Cadherin_CS	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.29e-03	109	138	5	IPR020894
Domain	Znf_RING_CS	RNF31 TRIM73 TRIM21 RBCK1 TRIM50 TRIM74	1.34e-03	163	138	6	IPR017907
Domain	Cadherin_2	PCDHGA7 PCDHA11 PCDH1 PCDH8	1.36e-03	65	138	4	PF08266
Domain	Cadherin_N	PCDHGA7 PCDHA11 PCDH1 PCDH8	1.36e-03	65	138	4	IPR013164
Domain	DAD_dom	FHOD3 FMNL1	1.47e-03	8	138	2	IPR014767
Domain	DAD	FHOD3 FMNL1	1.47e-03	8	138	2	PS51231
Domain	CADHERIN_1	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.52e-03	113	138	5	PS00232
Domain	Cadherin	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.52e-03	113	138	5	PF00028
Domain	CADHERIN_2	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.58e-03	114	138	5	PS50268
Domain	-	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.58e-03	114	138	5	2.60.40.60
Domain	CA	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.64e-03	115	138	5	SM00112
Domain	SPEC	TRIO SPTBN5 PLEC	1.67e-03	32	138	3	SM00150
Domain	Spectrin/alpha-actinin	TRIO SPTBN5 PLEC	1.67e-03	32	138	3	IPR018159
Domain	BBOX	TRIM73 TRIM21 TRIM50 TRIM74	1.70e-03	69	138	4	SM00336
Domain	Cadherin-like	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.70e-03	116	138	5	IPR015919
Domain	Znf_C3HC4_RING-type	TRIM73 TRIM21 RBCK1 TRIM50 RNF139 TRIM74	1.76e-03	172	138	6	IPR018957
Domain	EGF	LAMA3 CUBN TECTA LRP1B GPR179 LRP1 NOTCH1	1.83e-03	235	138	7	SM00181
Domain	IGc2	TRIO SPEG OBSCN HAPLN4 PTK7 HMCN2 ICAM5	1.83e-03	235	138	7	SM00408
Domain	Ig_sub2	TRIO SPEG OBSCN HAPLN4 PTK7 HMCN2 ICAM5	1.83e-03	235	138	7	IPR003598
Domain	Cadherin	DCHS2 PCDHGA7 PCDHA11 PCDH1 PCDH8	1.84e-03	118	138	5	IPR002126
Domain	-	TRIM73 TRIM21 TRIM50 TRIM74	1.89e-03	71	138	4	4.10.45.10
Domain	zf-B_box	TRIM73 TRIM21 TRIM50 TRIM74	1.99e-03	72	138	4	PF00643
Domain	EGF_CA	CUBN LRP1B HMCN2 LRP1 NOTCH1	2.13e-03	122	138	5	SM00179
Domain	EGF-like_Ca-bd_dom	CUBN LRP1B HMCN2 LRP1 NOTCH1	2.28e-03	124	138	5	IPR001881
Domain	EGF	CUBN TECTA LRP1B LRP1 NOTCH1	2.45e-03	126	138	5	PF00008
Domain	GBD/FH3_dom	FHOD3 FMNL1	2.85e-03	11	138	2	IPR014768
Domain	GBD_FH3	FHOD3 FMNL1	2.85e-03	11	138	2	PS51232
Domain	EGF_1	ADAM21 LAMA3 CUBN LRP1B HMCN2 LRP1 NOTCH1	2.90e-03	255	138	7	PS00022
Domain	Ig_I-set	TRIO SPEG OBSCN PTK7 HMCN2 ICAM5	2.90e-03	190	138	6	IPR013098
Domain	I-set	TRIO SPEG OBSCN PTK7 HMCN2 ICAM5	2.90e-03	190	138	6	PF07679
Domain	GDS_CDC24_CS	TRIO OBSCN ARHGEF11	2.97e-03	39	138	3	IPR001331
Domain	EGF-like_CS	ADAM21 LAMA3 CUBN LRP1B HMCN2 LRP1 NOTCH1	3.30e-03	261	138	7	IPR013032
Domain	C8	MUC5B TECTA	3.41e-03	12	138	2	PF08742
Domain	TIL	MUC5B TECTA	3.41e-03	12	138	2	PF01826
Domain	Kinesin-like_fam	KIF26A KIF12 KIF24	3.92e-03	43	138	3	IPR027640
Domain	Unchr_dom_Cys-rich	MUC5B TECTA	4.01e-03	13	138	2	IPR014853
Domain	C8	MUC5B TECTA	4.01e-03	13	138	2	SM00832
Domain	IG	TRIO SPEG ICAM3 OBSCN HAPLN4 SEMA4G PTK7 HMCN2 ICAM5	4.11e-03	421	138	9	SM00409
Domain	Ig_sub	TRIO SPEG ICAM3 OBSCN HAPLN4 SEMA4G PTK7 HMCN2 ICAM5	4.11e-03	421	138	9	IPR003599
Domain	-	KIF26A KIF12 KIF24	4.19e-03	44	138	3	3.40.850.10
Domain	Kinesin	KIF26A KIF12 KIF24	4.19e-03	44	138	3	PF00225
Domain	KISc	KIF26A KIF12 KIF24	4.19e-03	44	138	3	SM00129
Domain	KINESIN_MOTOR_1	KIF26A KIF12 KIF24	4.19e-03	44	138	3	PS00411
Domain	Kinesin_motor_dom	KIF26A KIF12 KIF24	4.19e-03	44	138	3	IPR001752
Domain	KINESIN_MOTOR_2	KIF26A KIF12 KIF24	4.19e-03	44	138	3	PS50067
Domain	TIL_dom	MUC5B TECTA	4.65e-03	14	138	2	IPR002919
Domain	IBR	RNF31 RBCK1	4.65e-03	14	138	2	PF01485
Domain	IRS	TLN1 TLN2	4.65e-03	14	138	2	PF02174
Domain	IRS_PTB	TLN1 TLN2	4.65e-03	14	138	2	IPR002404
Domain	Ldl_recept_b	LRP1B LRP1	4.65e-03	14	138	2	PF00058
Domain	LDLRB	LRP1B LRP1	4.65e-03	14	138	2	PS51120
Domain	FH2	FHOD3 FMNL1	5.34e-03	15	138	2	PS51444
Domain	FH2_Formin	FHOD3 FMNL1	5.34e-03	15	138	2	IPR015425
Domain	FH2	FHOD3 FMNL1	5.34e-03	15	138	2	PF02181
Domain	LY	LRP1B LRP1	5.34e-03	15	138	2	SM00135
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_TNF_NFKB_SIGNALING_PATHWAY_LUBAC_MEDIATED_LINEAR_UBIQUITINATION	RNF31 IKBKG RBCK1	7.03e-06	6	101	3	M47899
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	RNF31 BCL2L11 TRIO OBSCN IKBKG ARHGEF18 ARHGEF11 RBCK1	7.99e-06	142	101	8	MM15431
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	RNF31 BCL2L11 TRIO OBSCN IKBKG ARHGEF18 ARHGEF11 RBCK1	1.45e-05	154	101	8	M27697
Pathway	PID_RHOA_REG_PATHWAY	ARHGEF28 TRIO OBSCN ARHGEF18 ARHGEF11	1.86e-05	46	101	5	M68
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	BCL2L11 TRIO OBSCN ARHGEF18 ARHGEF11	3.40e-05	52	101	5	MM14743
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	BCL2L11 TRIO OBSCN ARHGEF18 ARHGEF11	6.30e-05	59	101	5	M11215
Pathway	KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM	PHGDH BHMT AGXT SARDH	6.73e-05	31	101	4	M766
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	BCL2L11 TRIO OBSCN ARHGEF18 ARHGEF11	1.43e-04	70	101	5	MM14824
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	BCL2L11 TRIO OBSCN ARHGEF18 ARHGEF11	2.11e-04	76	101	5	M19832
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	TRIO OBSCN ARHGEF18 ARHGEF11 ADRA1D	2.24e-04	77	101	5	MM15044
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	TRIO OBSCN ARHGEF18 ARHGEF11 ADRA1D	2.68e-04	80	101	5	M800
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	BCL2L11 TRIO OBSCN ARHGEF18 ARHGEF11	3.56e-04	85	101	5	MM14746
Pubmed	TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.	TRIM73 NLRP3 TRIM50 TRIM74	3.75e-09	6	140	4	36178239
Pubmed	Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.	TRIM73 TRIM50 TRIM74	6.38e-08	3	140	3	26196062
Pubmed	TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.	TRIM73 TRIM50 TRIM74	6.38e-08	3	140	3	22872646
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	SYNM SIPA1L3 ARHGEF18 CNTROB ALMS1 SEC16A LRP1 NOTCH1 CCDC102A	6.44e-08	184	140	9	32908313
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E DNAJC13 TRIO SIPA1L3 ARHGEF18 ZNFX1 TRIM21 FYCO1 ARHGEF11 ZNF462 ICAM5 SEC16A LRP1 CDK5RAP2 DLG2 TLN2 PCDH8 SMG6	6.99e-08	963	140	18	28671696
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	OBSCN TRIM21 MAP3K12 SPTBN5 GLG1 HACE1 LRP1 PLEC AGAP3	2.33e-07	214	140	9	22199357
Pubmed	The hepatitis C virus protein NS3 suppresses TNF-α-stimulated activation of NF-κB by targeting LUBAC.	RNF31 IKBKG RBCK1	2.55e-07	4	140	3	26577923
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	KRT4 PSMA2 CNTRL OBSCN FAM161B TRIM21 FYCO1 KRT73 VPS13D SEC16A HAL PLEC CCDC102A	5.14e-07	564	140	13	21565611
Pubmed	The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.	RNF31 IKBKG RBCK1	6.35e-07	5	140	3	27893701
Pubmed	SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.	RNF31 IKBKG RBCK1	6.35e-07	5	140	3	21455181
Pubmed	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.	TRIM73 TRIM50 TRIM74	6.35e-07	5	140	3	20049703
Pubmed	Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.	TRIM73 TRIM50 TRIM74	6.35e-07	5	140	3	18398435
Pubmed	TRIM50 regulates Beclin 1 proautophagic activity.	TRIM73 TRIM50 TRIM74	1.27e-06	6	140	3	29604308
Pubmed	Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.	RNF31 IKBKG RBCK1	1.27e-06	6	140	3	33215740
Pubmed	The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.	RNF31 IKBKG RBCK1	1.27e-06	6	140	3	23453807
Pubmed	The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC.	RNF31 IKBKG RBCK1	2.21e-06	7	140	3	32019898
Pubmed	Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.	TRIM73 TRIM50 TRIM74	2.21e-06	7	140	3	26025256
Pubmed	Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.	RNF31 IKBKG RBCK1	2.21e-06	7	140	3	23104095
Pubmed	A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.	RNF31 IKBKG RBCK1	2.21e-06	7	140	3	30913450
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	BCL2L11 TRIO KIF26A SPEG SIPA1L3 OBSCN FYCO1 ARHGEF11 CNTROB TLN1 SEC16A NINL TLN2 PLEC NOTCH1 SMG6 AGAP3	2.41e-06	1105	140	17	35748872
Pubmed	A protein quality control pathway regulated by linear ubiquitination.	RNF31 IKBKG RBCK1	3.52e-06	8	140	3	30886048
Pubmed	SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.	RNF31 IKBKG RBCK1	3.52e-06	8	140	3	21455180
Pubmed	A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7.	RNF31 IKBKG RBCK1	3.52e-06	8	140	3	23032186
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SIPA1L3 ZNF462 ALMS1 TLN1 SEC16A TLN2 SMG6 NIN	3.89e-06	225	140	8	12168954
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 SPAST TRIO SYNM SIPA1L3 ZNFX1 CBFB LRP1B BRWD3 RBCK1 LRP1 MAP3K10 DLG2 TLN2 PLEC ALDH5A1 PINK1 AGAP3	4.39e-06	1285	140	18	35914814
Pubmed	Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.	RNF31 IKBKG RBCK1	5.27e-06	9	140	3	28249776
Pubmed	The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.	RNF31 IKBKG RBCK1	5.27e-06	9	140	3	34755089
Pubmed	Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.	RNF31 IKBKG RBCK1	5.27e-06	9	140	3	33815386
Pubmed	Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.	RNF31 IKBKG RBCK1	5.27e-06	9	140	3	23032187
Pubmed	LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.	RNF31 IKBKG RBCK1	5.27e-06	9	140	3	21811235
Pubmed	Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains.	RNF31 IKBKG RBCK1	7.50e-06	10	140	3	34610306
Pubmed	A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.	CNTRL CDK5RAP2 NIN	7.50e-06	10	140	3	25220058
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DNAJC13 TRIO SIPA1L3 PRR5 OBSCN LAMA3 ARHGEF18 TECTA MAP3K12 BRWD3 HEXIM2 PTK7 ZNF462 GTF3C1 LRP1 GPT2 PCDH1 SMG6 AGAP3	8.82e-06	1489	140	19	28611215
Pubmed	EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination.	RNF31 IKBKG RBCK1	1.03e-05	11	140	3	23732909
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARHGEF28 SPAST TRIO SIPA1L3 PRR5 FSIP2 VPS13D ALMS1 SEC16A MAP3K10 PLEC PLEKHA7 CCDC102A AGAP3	1.07e-05	861	140	14	36931259
Pubmed	Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.	RNF31 IKBKG RBCK1	1.37e-05	12	140	3	19136968
Pubmed	The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.	RNF31 IKBKG RBCK1	1.37e-05	12	140	3	22607974
Pubmed	Tumour necrosis factor signalling in health and disease.	RNF31 IKBKG RBCK1	1.37e-05	12	140	3	30755793
Pubmed	Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.	RNF31 IKBKG RBCK1	1.37e-05	12	140	3	27552911
Pubmed	LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.	RNF31 IKBKG RBCK1	1.37e-05	12	140	3	26670046
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	SIPA1L3 CNTROB ALMS1 SEC16A NINL PLEKHA7 FMNL1 NOTCH1 AGAP3 NIN	1.42e-05	446	140	10	24255178
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ZNFX1 ARHGEF11 VPS13D ALMS1 HACE1 CDK5RAP2	1.51e-05	130	140	6	12421765
Pubmed	Liver X receptors agonists suppress NLRP3 inflammasome activation.	NR1H3 NLRP3	1.61e-05	2	140	2	27987394
Pubmed	Striking differences of LDL receptor-related protein 1B expression in mouse and human.	LRP1B LRP1	1.61e-05	2	140	2	15963947
Pubmed	CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation.	CNTRL NIN	1.61e-05	2	140	2	11956314
Pubmed	The E3 ubiquitin ligase RNF31 mediates the development of ulcerative colitis by regulating NLRP3 inflammasome activation.	RNF31 NLRP3	1.61e-05	2	140	2	37951199
Pubmed	RBCK1 promotes hepatocellular carcinoma metastasis and growth by stabilizing RNF31.	RNF31 RBCK1	1.61e-05	2	140	2	35869046
Pubmed	CBFβ enhances de novo protein biosynthesis of its binding partners HIV-1 Vif and RUNX1 and potentiates the Vif-induced degradation of APOBEC3G.	APOBEC3G CBFB	1.61e-05	2	140	2	24522927
Pubmed	Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements.	RNF31 IKBKG	1.61e-05	2	140	2	24030825
Pubmed	Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.	TLN1 TLN2	1.61e-05	2	140	2	26822056
Pubmed	Extracellular rigidity sensing by talin isoform-specific mechanical linkages.	TLN1 TLN2	1.61e-05	2	140	2	26523364
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	1.61e-05	2	140	2	15185077
Pubmed	RBCK1 Overexpression Attenuates Inflammation and Mobility of Derp1-Induced Nasal Mucosal Cells by Downregulating NLRP3.	NLRP3 RBCK1	1.61e-05	2	140	2	36702106
Pubmed	Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells.	ICAM3 ICAM5	1.61e-05	2	140	2	22117198
Pubmed	Novel autosomal recessive LAMA3 and PLEC variants underlie junctional epidermolysis bullosa generalized intermediate and epidermolysis bullosa simplex with muscular dystrophy in two consanguineous families.	LAMA3 PLEC	1.61e-05	2	140	2	29797489
Pubmed	Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury.	NLRP3 PINK1	1.61e-05	2	140	2	24778451
Pubmed	New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.	TLN1 TLN2	1.61e-05	2	140	2	22306379
Pubmed	Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin.	SYNM TLN1	1.61e-05	2	140	2	18342854
Pubmed	The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.	NLRP3 RBCK1	1.61e-05	2	140	2	24958845
Pubmed	Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance.	ATAD2 KIF24	1.61e-05	2	140	2	24391143
Pubmed	PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation.	NLRP3 PINK1	1.61e-05	2	140	2	32947010
Pubmed	Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.	RNF31 RBCK1	1.61e-05	2	140	2	26008899
Pubmed	TSG101 Physically Interacts with Linear Ubiquitin Chain Assembly Complex (LUBAC) and Upregulates the TNFα-Induced NF-κB Activation.	RNF31 IKBKG RBCK1	1.77e-05	13	140	3	37431163
Pubmed	--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.	RNF31 IKBKG RBCK1	1.77e-05	13	140	3	27810922
Pubmed	Direct activation of protein kinases by unanchored polyubiquitin chains.	RNF31 IKBKG RBCK1	1.77e-05	13	140	3	19675569
Pubmed	Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.	RNF31 RBCK1 AGAP3	2.25e-05	14	140	3	32123171
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	BCL2L11 OBSCN ARHGEF18 ARHGEF11	2.75e-05	43	140	4	12376548
Pubmed	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.	RNF31 IKBKG RBCK1	2.80e-05	15	140	3	23986494
Pubmed	Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.	RNF31 IKBKG RBCK1	2.80e-05	15	140	3	20005846
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CNTRL CNTROB ALMS1 BBS7 CDK5RAP2 NIN	2.92e-05	146	140	6	21399614
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLIN4 ARHGEF28 SYNM SIPA1L3 ARHGEF18 SEMA4G ZNF462 SMYD4 VPS13D ALMS1	3.32e-05	493	140	10	15368895
Pubmed	The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.	TRIM73 TRIM50 TRIM74	3.44e-05	16	140	3	22792322
Pubmed	Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.	KIF12 CUBN BHMT	4.17e-05	17	140	3	21082674
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TRIO SIPA1L3 CNTRL ARHGEF11 LRP1B VPS52 ALMS1 TLN1 NINL PLEC PLEKHA7 CBX8 NIN	4.36e-05	853	140	13	28718761
Pubmed	Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.	TLN1 TLN2	4.81e-05	3	140	2	12422220
Pubmed	Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders.	RNF31 RBCK1	4.81e-05	3	140	2	32403254
Pubmed	HIV type 1 viral infectivity factor and the RUNX transcription factors interact with core binding factor β on genetically distinct surfaces.	APOBEC3G CBFB	4.81e-05	3	140	2	22725134
Pubmed	Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB.	RNF31 RBCK1	4.81e-05	3	140	2	33392484
Pubmed	Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain.	RNF31 IKBKG	4.81e-05	3	140	2	35851409
Pubmed	Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.	TLN1 TLN2	4.81e-05	3	140	2	18792400
Pubmed	Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop.	NLRP3 PINK1	4.81e-05	3	140	2	29665074
Pubmed	Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-κB-mediated NLRP3 inflammasome activation.	TRIM21 NLRP3	4.81e-05	3	140	2	33992596
Pubmed	Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion.	TLN1 TLN2	4.81e-05	3	140	2	22665520
Pubmed	An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.	TLN1 TLN2	4.81e-05	3	140	2	17202407
Pubmed	Structural basis for ubiquitylation by HOIL-1.	RNF31 RBCK1	4.81e-05	3	140	2	36685275
Pubmed	Identification and molecular analysis of RNF31 Q622H germline polymorphism.	RNF31 RBCK1	4.81e-05	3	140	2	36276481
Pubmed	Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis.	APOBEC3G CBFB	4.81e-05	3	140	2	24418540
Pubmed	Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31.	RNF31 IKBKG	4.81e-05	3	140	2	27669734
Pubmed	A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.	RNF31 RBCK1	4.81e-05	3	140	2	22430200
Pubmed	Mechanotransduction in talin through the interaction of the R8 domain with DLC1.	TLN1 TLN2	4.81e-05	3	140	2	30028837
Pubmed	Vinculin and talin: focus on the myocardium.	TLN1 TLN2	4.81e-05	3	140	2	19952892
Pubmed	Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.	RNF31 RBCK1	4.81e-05	3	140	2	24141947
Pubmed	Talin depletion reveals independence of initial cell spreading from integrin activation and traction.	TLN1 TLN2	4.81e-05	3	140	2	19160486
Pubmed	Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.	TLN1 TLN2	4.81e-05	3	140	2	27816808
Pubmed	Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.	NINL NIN	4.81e-05	3	140	2	16254247
Pubmed	The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.	RNF31 RBCK1	4.81e-05	3	140	2	26525107
Pubmed	PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.	NLRP3 PINK1	4.81e-05	3	140	2	31229841
Pubmed	Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.	TLN1 TLN2	4.81e-05	3	140	2	15494027
Pubmed	Vinculin controls talin engagement with the actomyosin machinery.	TLN1 TLN2	4.81e-05	3	140	2	26634421
Pubmed	Biochemical and functional characterization of the N-terminal ubiquitin-like domain of human SHARPIN.	RNF31 RBCK1	4.81e-05	3	140	2	34965468
Interaction	KRT19 interactions	KRT4 RNF31 SYNM ARHGEF11 CNTROB KRT73 ALMS1 USHBP1 NINL CDK5RAP2 PLEC NIN	5.67e-07	282	138	12	int:KRT19
Interaction	SASS6 interactions	SIPA1L3 FYCO1 CNTROB ALMS1 SEC16A NINL CDK5RAP2 EXOC3L1 NIN	1.52e-06	159	138	9	int:SASS6
Interaction	SQSTM1 interactions	DNAJC13 ARHGEF28 RNF31 TRIO SIPA1L3 CNTRL ACOT7 IKBKG EMILIN3 ARHGEF18 FHOD3 TRIM21 PHGDH NLRP3 ALMS1 GLG1 GJD3 SEC16A CDK5RAP2 TRIM50 NOTCH1 SOD3 PINK1 CCDC102A	4.41e-06	1257	138	24	int:SQSTM1
Interaction	CCDC138 interactions	CNTRL IKBKG FAM161B ANGPT4 NINL SMG6 NIN	2.22e-05	123	138	7	int:CCDC138
Interaction	TNRC6A interactions	RNF31 SYNM CNTRL IKBKG TRIM21 CNTROB RBCK1 SEC16A NINL NIN	2.37e-05	280	138	10	int:TNRC6A
Interaction	TRIM37 interactions	SYNM SIPA1L3 IKBKG ARHGEF18 TRIM21 CNTROB ALMS1 BBS7 SEC16A LRP1 NINL CDK5RAP2 PLEC NOTCH1 CCDC102A	2.82e-05	630	138	15	int:TRIM37
Interaction	SPATA2 interactions	RNF31 CNTRL IKBKG CNTROB RBCK1 NIN	2.96e-05	87	138	6	int:SPATA2
Interaction	CCDC14 interactions	RNF31 CNTRL IKBKG CNTROB NINL CDK5RAP2 NIN	3.02e-05	129	138	7	int:CCDC14
Interaction	KRT18 interactions	KRT4 RNF31 SIPA1L3 IKBKG CNTROB PHGDH KRT73 ALMS1 BBS7 SEC16A PLEC NIN	3.21e-05	419	138	12	int:KRT18
Interaction	STIL interactions	SIPA1L3 CNTROB ALMS1 BBS7 SEC16A NINL CDK5RAP2 NIN	5.03e-05	190	138	8	int:STIL
Interaction	KRT8 interactions	RNF31 SYNM SIPA1L3 IKBKG CNTROB KRT73 ALMS1 SEC16A NINL CDK5RAP2 PLEC NIN	5.26e-05	441	138	12	int:KRT8
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO OBSCN ARHGEF18 ARHGEF11	4.35e-04	66	97	4	722
GeneFamily	Ring finger proteins	RNF31 TRIM73 TRIM21 RBCK1 TRIM50 RNF139 TRIM74	6.99e-04	275	97	7	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM73 TRIM21 TRIM50 TRIM74	1.71e-03	95	97	4	59
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TRIO SPEG OBSCN PTK7 HMCN2	1.75e-03	161	97	5	593
GeneFamily	Non-clustered protocadherins	PCDH1 PCDH8	1.82e-03	12	97	2	21
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF26A KIF12 KIF24	1.92e-03	46	97	3	622
GeneFamily	Low density lipoprotein receptors	LRP1B LRP1	2.14e-03	13	97	2	634
GeneFamily	Immunoglobulin like domain containing	ICAM3 SEMA4G PTK7 HMCN2 ICAM5	3.84e-03	193	97	5	594
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RNF31 RBCK1	5.60e-03	21	97	2	89
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E SIPA1L3 FHOD3 CUBN BHMT GLG1 TLN2 GPT2 PLEKHA7	7.98e-09	186	140	9	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	Skin-Mesangial\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	PLIN4 CACNA1E DCHS2 SYNM SPEG TECTA ADRA1D FMNL1 SOD3	1.44e-08	199	140	9	bcb78838a91cc7828680fb413fbacdb091c5fac0
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBXAS1 OLFML2B NLRP3 TLN1 LRP1 DSE AGAP3	1.14e-06	170	140	7	9ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SYNM SPEG LRP1B SSC5D FRRS1L SPOCD1 SOD3	1.55e-06	178	140	7	8ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SYNM SPEG LRP1B SSC5D FRRS1L SPOCD1 SOD3	1.55e-06	178	140	7	6c91331196696e0cf239d105f458e3230659fa38
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	OLFML2B NR1H3 TECTA LRP1 TDRD6 ADAMTSL4 DSE	2.01e-06	185	140	7	7bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRIP1 ACOT7 GIMAP1 PHGDH MMP25 ZNF462 CD163L1	2.08e-06	186	140	7	61de94c9ba90e7b6780694199c059c798b1488ae
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SIPA1L3 FHOD3 CUBN BHMT GLG1 GPT2 PLEKHA7	2.16e-06	187	140	7	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGEF28 KIF12 FHOD3 CUBN LRP1B BHMT PLEKHA7	2.16e-06	187	140	7	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ARHGEF28 NR1H3 LRP1 SPOCD1 ADAMTSL4 FMNL1 DSE	2.32e-06	189	140	7	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SIPA1L3 FHOD3 CUBN BHMT NINL TLN2 PLEKHA7	2.48e-06	191	140	7	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SIPA1L3 FHOD3 CUBN BHMT NINL TLN2 PLEKHA7	2.48e-06	191	140	7	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 KIF12 FHOD3 CUBN LRP1B NINL PLEKHA7	2.66e-06	193	140	7	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 SIPA1L3 KIF12 FHOD3 CUBN NINL PLEKHA7	2.66e-06	193	140	7	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-FOXM1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	BRIP1 CNTRL ATAD2 KIF24 GJD3 CDK5RAP2 PSRC1	3.26e-06	199	140	7	98575fcce726589e93fbb4df1aab03e57cb56076
ToppCell	wk_20-22-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	EPHB2 OLFML2B EMILIN3 PHGDH SSC5D HMCN2 ADAMTSL4	3.26e-06	199	140	7	ab0589c068c24aa989bdca083504fbad0c15221d
ToppCell	Control_saline-Endothelial-Endothelial-FOXM1\|Control_saline / Treatment groups by lineage, cell group, cell type	BRIP1 CNTRL ATAD2 CNTROB KIF24 CDK5RAP2 PSRC1	3.37e-06	200	140	7	9bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCell	COVID-CD8-memory_CD4\|COVID / Condition, Cell_class and T cell subcluster	SYNM GTF3C1 UBAP1L PLEKHA7 ALDH5A1 CCDC157	1.25e-05	162	140	6	22b2a32217d357146c117e618813d451510a1801
ToppCell	390C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	BCL2L11 KIF12 PTK7 MMP25 CCDC157 CCDC102A	1.76e-05	172	140	6	3f894c74916d49a995b2d4651ca1c6733c14ce9c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIO ANGPT4 LRP1 SPOCD1 ADAMTSL4 FMNL1	1.88e-05	174	140	6	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPHB2 OLFML2B PHGDH HMCN2 ANGPT4 LRP1	2.27e-05	180	140	6	9adebde5f4ca6dcb90e9113622862e14298465ac
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E ARHGEF28 KIF12 FHOD3 CUBN BHMT	2.27e-05	180	140	6	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPHB2 OLFML2B PHGDH HMCN2 ANGPT4 LRP1	2.42e-05	182	140	6	e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGEF28 KIF12 FHOD3 CUBN LRP1B BHMT	2.42e-05	182	140	6	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 LAMA3 ATAD2 KIF24 CDK5RAP2 PSRC1	2.65e-05	185	140	6	30e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIF26A LAMA3 SLC35F4 ADRA1D PLEKHA7 PCDH8	2.65e-05	185	140	6	4c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OLFML2B KCND1 DLG2 TDRD6 ADAMTSL4 AGAP3	2.73e-05	186	140	6	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LAMA3 LRP1B KIF24 TLN1 LRP1 PLEC	2.73e-05	186	140	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OLFML2B HRCT1 FHOD3 ADRA1D NINL SOD3	2.73e-05	186	140	6	26458ff8cad5577de4306cffa0ca69eb26940e0d
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OLFML2B HRCT1 FHOD3 ADRA1D NINL SOD3	2.73e-05	186	140	6	a71397efc68d2916ddc373d92cfd07be58033e1c
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OLFML2B KCND1 DLG2 TDRD6 ADAMTSL4 AGAP3	2.73e-05	186	140	6	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ARHGEF28 HRCT1 LAMA3 HMCN2 NINL TDRD6	2.73e-05	186	140	6	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 LAMA3 ATAD2 KIF24 CDK5RAP2 PSRC1	2.81e-05	187	140	6	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLIN4 OLFML2B SPEG HRCT1 ADRA1D PLEKHA7	2.90e-05	188	140	6	61f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCell	droplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLIN4 OLFML2B SPEG HRCT1 ADRA1D PLEKHA7	2.90e-05	188	140	6	7553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell	(2)_Fibroblasts-(20)_Fibro-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	OLFML2B SSC5D HMCN2 LRP1 ADAMTSL4 SOD3	2.90e-05	188	140	6	409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCell	facs-Trachea-nan-18m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HRCT1 USHBP1 EXOC3L1 TRIM50 PCDH1 NOTCH1	2.99e-05	189	140	6	100eda87ac9c38dddcfa58408b057867a1738acb
ToppCell	facs-Trachea-nan-18m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HRCT1 USHBP1 EXOC3L1 TRIM50 PCDH1 NOTCH1	2.99e-05	189	140	6	5ced78f4b5c276b1bab24df807c00cf5ac8ed3d4
ToppCell	facs-Trachea-nan-18m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HRCT1 USHBP1 EXOC3L1 TRIM50 PCDH1 NOTCH1	2.99e-05	189	140	6	2105d8b011b93a460237e00bc029efd7762dc8d5
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG SSC5D ANGPT4 LRP1 ADAMTSL4 SOD3	2.99e-05	189	140	6	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	TBXAS1 SSC5D LRP1 TLN2 PLEC SOD3	3.17e-05	191	140	6	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG FHOD3 SSC5D ANGPT4 ADAMTSL4 SOD3	3.17e-05	191	140	6	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLIN4 OLFML2B SPEG HRCT1 FHOD3 ADRA1D	3.26e-05	192	140	6	2cc712186e37fb21a964c032765c36a8b4a852cf
ToppCell	Macrophages-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	TBXAS1 L1TD1 ACOT7 LRP1 SPOCD1 ADAMTSL4	3.36e-05	193	140	6	a6694b33adcdb17cdd1567eb9507dbf06e6468d8
ToppCell	normal_Pleural_Fluid-T/NK_cells-CD8_low_T\|T/NK_cells / Location, Cell class and cell subclass	TBXAS1 ANKRD35 SYNM APOBEC3G GADD45G DSE	3.46e-05	194	140	6	cf2480cc40f3c9be837b3934547e2ce30bd4fcd3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 SIPA1L3 FHOD3 CUBN NINL PLEKHA7	3.46e-05	194	140	6	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	P28-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ANKRD35 CACNA1E OLFML2B FHOD3 SSC5D GADD45G	3.46e-05	194	140	6	3c661c6768c3f05d2aba03d329adb257ca201b2d
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 OLFML2B NLRP3 CD163L1 LRP1 FMNL1	3.46e-05	194	140	6	abce1e824ce2512741c313a5ec336d12f580b093
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BRIP1 OLFML2B FHOD3 SSC5D GADD45G SOD3	3.46e-05	194	140	6	7bf6edefd13047e04665dbe34051ef3f481f85a4
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 OLFML2B NLRP3 CD163L1 LRP1 FMNL1	3.46e-05	194	140	6	6810586080cc893e3270b9c8bee2d95ed78e2893
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 OLFML2B CD163L1 LRP1 FMNL1 AGAP3	3.46e-05	194	140	6	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BRIP1 OLFML2B FHOD3 SSC5D GADD45G SOD3	3.46e-05	194	140	6	19e5beae2c1f8bf42cbe618e89810ce7b01a396c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 SIPA1L3 FHOD3 LRP1B NINL PLEKHA7	3.56e-05	195	140	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	TRIO SIPA1L3 ICAM3 KIF12 TRIM21 NOTCH1	3.66e-05	196	140	6	7be50b9156394dea44d7b8b476d4dd516abfafae
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 SIPA1L3 KIF12 FHOD3 NINL PLEKHA7	3.66e-05	196	140	6	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	PRR5 APOBEC3G GIMAP1 ZNFX1 TRIM21 RBCK1	3.66e-05	196	140	6	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Mucous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PCDHGA7 SIPA1L3 MUC5B DLG2 SARDH ATP12A	3.87e-05	198	140	6	2ae9564da9913510141994262f3739eb095e0a68
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBXAS1 NLRP3 CD163L1 SPOCD1 ADAMTSL4 FMNL1	3.98e-05	199	140	6	98c0d57c247d39bc771d81f4387f8dd01222628e
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	EPHB2 DCHS2 TRIO SSC5D ADAMTSL4 SOD3	3.98e-05	199	140	6	8de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	L1TD1 EMILIN3 MUC5B CUBN KIF24 BHMT	4.10e-05	200	140	6	29054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	ARHGEF11 SPTBN5 VPS13D LRP1 NIN	4.20e-05	122	140	5	1ed865f0ecfe304fb86313ff51c04e9052357270
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBXAS1 NR1H3 NLRP3 TLN1 TLN2	4.54e-05	124	140	5	e9b6fdac2bef4bf1fee6a486f4628b68adc80f57
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACOT7 CUBN LRP1B PHGDH GPR179	7.55e-05	138	140	5	c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Smooth_Muscle-like_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	EPHB2 PLIN4 CACNA1E EMILIN3 FHOD3	8.08e-05	140	140	5	5623a0a68403fc00166b7d13d13e184a718d9bdd
ToppCell	PBMC-Mild-cDC_7\|Mild / Compartment, Disease Groups and Clusters	NEU4 NR1H3 NINL RNF139 PSRC1	8.64e-05	142	140	5	58f66f35646f281e64d634e6c26adbd1d4e6c830
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP29 TECTA LRP1B FRRS1L ATP12A	9.54e-05	145	140	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	390C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RNF31 TRIM73 L1TD1 TRIM21 UBAP1L	1.19e-04	152	140	5	ebce79e106bf1d84241f8dd3496ff1771f9666be
ToppCell	390C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RNF31 TRIM73 L1TD1 TRIM21 UBAP1L	1.19e-04	152	140	5	4a749d1b6d35fd55a8c42d7bd04b6ff5b11ce781
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADCK5 SPEG DCAF8L2 FHOD3 HMCN2	1.30e-04	155	140	5	cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	OLFML2B GTF3C1 LRP1	1.37e-04	32	140	3	ba89b22a5ce8ee9f3099b1fa84721724b94c7759
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	OLFML2B GTF3C1 LRP1	1.37e-04	32	140	3	58b212d4f2955f06a195df0f79ad95a8ff145b83
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRIP1 SIPA1L3 PRR5 ARHGEF18 ATAD2	1.39e-04	157	140	5	6730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCell	droplet-Liver-LIVER_NPC-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CNTRL ARHGEF18 GIMAP1 FMNL1	1.47e-04	159	140	5	997963d879e5819683793cddf5e1acff1b81a1b8
ToppCell	droplet-Liver-LIVER_NPC\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CNTRL ARHGEF18 GIMAP1 FMNL1	1.47e-04	159	140	5	e4eaa88772835d6b78e1a18a0cec52de51e80339
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	USP29 TECTA LRP1B FRRS1L ATP12A	1.60e-04	162	140	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	SYNM SPEG NR1H3 DLG2 PCDH1	1.60e-04	162	140	5	a957c7e347189b72fbd47db3075bb5e879a21c67
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPEG HRCT1 SSC5D MAP3K10 SARDH	1.65e-04	163	140	5	8f24cef152f5965727bbeee116bd26c75cbba82a
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBXAS1 KIF24 NLRP3 MMP25 CD163L1	1.65e-04	163	140	5	7af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 LAMA3 ATAD2 KIF24 SPTBN5	1.85e-04	167	140	5	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADCK5 ACOT7 DHRS13 ATAD2 KIF24	1.85e-04	167	140	5	9280558baddea51aae47f3383d895a9b0c6749a4
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	SPEG FHOD3 HMCN2 TLN2 CBX8	1.85e-04	167	140	5	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ICAM3 APOBEC3G CBFB MMP25 SARDH	1.90e-04	168	140	5	50991eb794742592a0c96cd9a72460ab339e74ff
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT4 FAM161B ATAD2 KIF24 ADRA1D	1.90e-04	168	140	5	ca65321259711321c175ede67bd67a47aad81d7a
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 NR1H3 BHMT BBS7 ADAMTSL4	1.95e-04	169	140	5	2d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 NR1H3 BHMT BBS7 ADAMTSL4	1.95e-04	169	140	5	ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 NR1H3 BHMT BBS7 ADAMTSL4	1.95e-04	169	140	5	ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	SYNM DHRS13 KRT73 FSIP2 KCND1	1.95e-04	169	140	5	bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCell	normal_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	OLFML2B OBSCN ADRA1D CD163L1 PCDH1	2.01e-04	170	140	5	d69c0ea4cb6b204f19d0a5d2164afb42184779ac
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DCHS2 OLFML2B LRP1B ADRA1D LRP1	2.01e-04	170	140	5	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	Cerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Sln_(Unipolar_brush_cell)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	OBSCN PCDHA11 EMILIN3 GJD3	2.03e-04	92	140	4	a5b89f971b904b8e280fe66996a7f8efd92c2132
ToppCell	Cerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Sln_(Unipolar_brush_cell)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	OBSCN PCDHA11 EMILIN3 GJD3	2.03e-04	92	140	4	b867cd7923585b13beaf086c40781bab2d7b7434
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E PRR5 CUBN BHMT GPT2	2.06e-04	171	140	5	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRR5 ARHGEF18 GIMAP1 PHGDH	2.06e-04	171	140	5	20ac3de9c164b409b70a30a8b6544ea491ef7c0e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 TECTA ATAD2 EXOC3L1 PSRC1	2.06e-04	171	140	5	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	normal_Lung-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	ARHGEF28 L1TD1 FYCO1 HEXIM2 GADD45G	2.06e-04	171	140	5	f49dfe11ae66d82125b577c48345a13683d7bb7b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Neutrophil\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 ICAM3 MMP25 HAL FMNL1	2.06e-04	171	140	5	ef9397cec7f5c217d34583f26270af7ed7fbcebf
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYNM ADCK5 TLN2 CCDC144A PINK1	2.12e-04	172	140	5	a03f30a996a9474ad4cccd209476423a042df002
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYNM ADCK5 TLN2 CCDC144A PINK1	2.12e-04	172	140	5	f92a53ad2e464cd68ba1714bcc1d5911479cdf1c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 MUC5B ATAD2 NLRP3 FMNL1	2.12e-04	172	140	5	ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG HRCT1 NR1H3 SEMA4G ADRA1D	2.18e-04	173	140	5	3059325901b1e5e12a1a91183f14267288b2f600
Disease	POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCY	RNF31 RBCK1	2.17e-05	2	138	2	C4014605
Disease	creatinine measurement	PLIN4 DNAJC13 BRIP1 SPEG SIPA1L3 OBSCN ARHGEF18 NR1H3 CUBN BRWD3 ALMS1 DCAF12L1 PLEC PLEKHA7 SOD3	6.83e-05	995	138	15	EFO_0004518
Disease	epilepsy (implicated_via_orthology)	CACNA1E TRIO LRP1B LRP1 ATP12A ALDH5A1	1.22e-04	163	138	6	DOID:1826 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	TBXAS1 BRIP1 SPAST OBSCN HAPLN4 GIMAP1 CUBN TECTA CBFB PHGDH ICAM5 EXOC3L1 SPOCD1 PCDH8 NOTCH1	1.58e-04	1074	138	15	C0006142
Disease	irritable bowel syndrome (implicated_via_orthology)	EPHB2 IKBKG	2.15e-04	5	138	2	DOID:9778 (implicated_via_orthology)
Disease	intelligence, response to cranial radiation therapy	DCHS2 PHGDH GTF3C1	3.01e-04	28	138	3	EFO_0004337, EFO_0010950
Disease	diastolic blood pressure, systolic blood pressure	BRIP1 SPEG EMILIN3 CNTROB PTK7 ADRA1D ALMS1 USHBP1 SEC16A LRP1 TLN2	3.24e-04	670	138	11	EFO_0006335, EFO_0006336
Disease	right ventricular ejection fraction measurement	OBSCN FHOD3 PLEC	3.70e-04	30	138	3	EFO_0021816
Disease	neuroimaging measurement	DCHS2 ARHGEF11 PTK7 ZNF462 GADD45G GJD3 NINL DLG2 TLN2 PLEC PLEKHA7 CBX8 SMG6 AGAP3	5.03e-04	1069	138	14	EFO_0004346
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	HAPLN4 PSRC1	5.97e-04	8	138	2	EFO_0008589, EFO_0008595
Disease	Macrocephaly	CACNA1E BRWD3	1.16e-03	11	138	2	C0221355
Disease	homocysteine measurement	DCHS2 CUBN MMUT	1.31e-03	46	138	3	EFO_0004578
Disease	intercellular adhesion molecule 5 measurement	ICAM3 ICAM5	1.64e-03	13	138	2	EFO_0008164
Disease	fibrinogen measurement	DCHS2 NLRP3 GADD45G PLEC	1.74e-03	109	138	4	EFO_0004623
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	HAPLN4 PSRC1	1.90e-03	14	138	2	EFO_0004611, EFO_0008589
Disease	neuroblastoma	TRIO L1TD1 MMP25 HACE1	2.19e-03	116	138	4	EFO_0000621
Disease	forehead morphology measurement	BRIP1 SMG6	2.19e-03	15	138	2	EFO_0007844
Disease	Proteinuria	CUBN SMG6	2.19e-03	15	138	2	HP_0000093
Disease	Congenital total cataract	SIPA1L3 FYCO1	2.50e-03	16	138	2	C0266539
Disease	triiodothyronine measurement	EPHB2 DLG2	2.50e-03	16	138	2	EFO_0008392
Disease	migraine without aura, susceptibility to, 4	LRP1 DLG2	2.50e-03	16	138	2	MONDO_0011847
Disease	blood metabolite measurement	ALMS1 SARDH	3.52e-03	19	138	2	EFO_0005664
Disease	X-24309 measurement	DNAJC13 ADRA1D	3.90e-03	20	138	2	EFO_0800872
Disease	Abdominal Aortic Aneurysm	USHBP1 LRP1 PSRC1	4.02e-03	68	138	3	EFO_0004214

Protein segments in the cluster

Peptide	Gene	Start	Entry
AGSCQREAARLAERN	USHBP1	166	Q8N6Y0
NGERCVAALARVERT	ACOT7	96	O00154
GQEVNEAACDIARQV	BHMT	96	Q93088
SASQGVNCIREDVAA	GPT2	151	Q8TD30
ARRAGSQECADILIQ	AGAP3	826	Q96P47
LVCRGADERTQAAER	EXOC3L1	606	Q86VI1
EECRSVIQEQAAALG	SMG6	961	Q86US8
ACQDRVLRVLQGSDV	BBS7	166	Q8IWZ6
GQDARERRECVNGHQ	ARHGEF18	286	Q6ZSZ5
TGQEEFRQACERALE	CNTRL	881	Q7Z7A1
RQVRCVGNNGDEVSE	ADAMTSL4	806	Q6UY14
DVSRCNSEERGTQAD	CACNA1E	2096	Q15878
SDVFCGRVQCENVRD	ADAM21	556	Q9UKJ8
DDQGRCQEGLRTLAE	APOBEC3G	316	Q9HC16
LDGLNENAVVCSERV	ALMS1	426	Q8TCU4
LRNSEDARGVLCEAQ	ARHGEF11	391	O15085
SDVSSECDREGRQLQ	BCL2L11	6	O43521
HSRDEECERVIQGIN	BRWD3	1141	Q6RI45
VSSLQGEDCREAVQR	COMMD5	56	Q9GZQ3
LDFENEGRNAERCAR	ADCK5	276	Q3MIX3
NTACREVGRLREAVA	ANKRD35	861	Q8N283
VARALANECSQGDKR	ATAD2	476	Q6PL18
RLVDGNNSCSGRVEV	CD163L1	156	Q9NR16
EQGARRRQAEEDEQC	CCDC157	321	Q569K6
VRCSGQELSRVQEEV	CDK5RAP2	1526	Q96SN8
TLENCTVARCVGDNR	MUC5B	5021	Q9HC84
TAGRIDREEICAQSA	PCDHGA7	86	Q9Y5G6
QAQGGSSCILREEAR	NR1H3	31	Q13133
QESCAGSDRNFVIDR	ARHGEF28	916	Q8N1W1
RCEGNFDAIANIRGE	MMP25	316	Q9NPA2
VNSRIDREELCGQSA	PCDHA11	86	Q9Y5I1
GEEQALCVRNRSAFE	KCND1	461	Q9NSA2
DRVQVLSQDCAVSGD	MAP3K10	41	Q02779
CEVAAQRQGVDVARL	NOTCH1	1101	P46531
RNNTCIAEGSEDQVL	LRP1B	3876	Q9NZR2
RNASGDELVRCAVDA	LAMA3	2161	Q16787
CANLETAIADAEQRG	KRT73	371	Q86Y46
QVCQREGSREQEDRG	GPR179	1166	Q6PRD1
LQCSEREGALQEERA	FYCO1	846	Q9BQS8
RQNGVCTDLDECRVR	HMCN2	4856	Q8NDA2
RECLQGTIRNSQEAE	RBCK1	306	Q9BYM8
DAARTQEDVFRACGV	KIF12	71	Q96FN5
DDRIFVCNRNGDTCV	LRP1	301	Q07954
ADIRVLSSQGCRVDN	ATP12A	216	P54707
CQTLQVSVADAEQRG	KRT4	376	P19013
CARDGQVRVAELINA	DCAF8L2	291	P0C7V8
ASVLAADTQQCRDGV	FSIP2	21	Q5CZC0
RQDCDVERNRTAAGG	HRCT1	36	Q6UXD1
AARGSCIANAEEVDV	EPHB2	221	P29323
AESRRAVSACQEIQA	PINK1	116	Q9BXM7
SAEQEGARQLVCNVT	ICAM5	291	Q9UMF0
VCNVTLGGENRETRE	ICAM5	301	Q9UMF0
TETSIDREGLRECQN	PCDH1	111	Q08174
FRVELQTRADGAQCA	PCDH8	181	O95206
QARFQNACRDGRSEI	CBFB	41	Q13951
LAGRQEASADCQDVI	HACE1	431	Q8IYU2
READLGEACQSRETV	KIF24	1146	Q5T7B8
ECQALEGRARAASEQ	IKBKG	166	Q9Y6K9
DLAASCQGRVVAAEE	DSE	516	Q9UL01
RAQRQGEEEAECHRQ	FAM161B	201	Q96MY7
QRVVDGCEVAARAAR	KIF26A	1281	Q9ULI4
AQLEQCALQDRESAG	PSRC1	86	Q6PGN9
EAVQIATGRNAARLC	NEU4	111	Q8WWR8
TARADQEGAREIVCN	ICAM3	281	P32942
DGQICVSQDIDRERD	DCHS2	721	Q6V1P9
ETDRGNRLANNSDCI	BRIP1	1151	Q9BX63
GCTRRLVVQEAGQAD	OBSCN	1586	Q5VST9
NQEAREGATAVLQCE	OBSCN	3546	Q5VST9
QEAREGATAVLQCEL	OBSCN	3811	Q5VST9
VECRNDFLEVRNGSN	CUBN	3446	O60494
CRDDRERFCENTQAG	GLG1	316	Q92896
CAFDNRATGREQEAQ	GIMAP1	186	Q8WWP7
GCEAVERASAIARQA	HAL	316	P42357
ARRQDSDLVQCGVTS	CBX8	251	Q9HC52
CVEIAREALNAGNRE	DNAJB14	11	Q8TBM8
RDEEGVFENNRVTCR	FRRS1L	191	Q9P0K9
CENDIDIVRVGDVQR	GADD45G	86	O95257
LAGARRERQEAQGEC	CCDC102A	136	Q96A19
TQDESVRRVDVGCLD	FHOD3	726	Q2V2M9
VAQQTRQEADRGCET	ANGPT4	21	Q9Y264
GERDNRCNRAHEEAQ	GJD3	221	Q8N144
NCSALNAEELRRENG	DNAJC13	1431	O75165
RVRADEVRLQCQSGS	MAP3K12	71	Q12852
AAGELEERFNRALNC	FMNL1	31	O95466
AQRACAEQDGILASA	HAPLN4	181	Q86UW8
LRDSEARLAQDQQGC	DCAF12L1	136	Q5VU92
GAAAEDGRLRVNDCI	DLG2	136	Q15700
EVRRQCEEGQAASRR	EMILIN3	336	Q9NT22
AAAVRDCDQSQTARD	CCDC144A	921	A2RUR9
RCCVLQEERDAARAG	CNTROB	326	Q8N137
ARVVLACRSQERGEA	DHRS13	61	Q6UX07
SRFQCIEDRNARLGE	NLRP3	146	Q96P20
DCDDDVQRERNGVIQ	RNF139	636	Q8WU17
AVQEERDAGVLSRVC	PLIN4	1246	Q96Q06
CNATRENVDRVTEAL	AGXT	366	P21549
AVQRLSGCQRDAESF	SMYD4	676	Q8IYR2
ADCGVREARAAVRAA	ALDH5A1	91	P51649
VQTAGEQVADRRNCI	TDRD6	1551	O60522
GQARCAEEARSLRQQ	SYNM	56	O15061
GQESRLQAEEETRLC	SYNM	216	O15061
REEVLCQAGASEQLA	NIN	951	Q8N4C6
AADERGTQQRRACAN	PRR5	26	P85299
TGQQSCRQVEELAAE	HEXIM2	241	Q96MH2
DRELGQCVNGDSRVE	PLEKHA7	966	Q6IQ23
RNEIGGECERNVSFS	SIPA1L3	431	O60292
AVIVTGQGEQCERAR	SPAST	161	Q9UBP0
GVVCAGQRVANSRDD	SSC5D	116	A1L4H1
ASCRGQAERLQAIQE	NINL	966	Q9Y2I6
RDACQRINAGASRKE	OLFML2B	86	Q68BL8
VCGHRVERQNRSADD	SLC35F4	121	A4IF30
ARAASARGAQVIENC	SARDH	221	Q9UL12
ARSTACGQQLAEVVE	SPTBN5	556	Q9NRC6
EGHCLAQDVEEQARR	SPTBN5	2856	Q9NRC6
AQRAEAACAQRSEVE	ADRA1D	526	P25100
EGCDQVARDLRAEFS	ARL6IP6	46	Q8N6S5
RHGNLDEAVEECVRT	RNF31	561	Q96EP0
RINDRQCTGIEGEDF	TECTA	1831	O75443
QGTRERLAQAECVLE	TRIM74	216	Q86UV6
VNDCIESGRQAAVSV	PPOX	456	P50336
AAAVREQEARGTAAC	VPS52	206	Q8N1B4
EQEARGTAACADVRG	VPS52	211	Q8N1B4
TREAAQDCEVLGQRI	TBXAS1	411	P24557
RRDEDAGEGIQCSQR	TMEM175	21	Q9BSA9
LIQDIERGNRGCESS	SEMA4G	546	Q9NTN9
ADRANVVGEVRETCV	SEC16A	626	O15027
QNERGRASCEAVLTV	SPEG	111	Q15772
QRRDDDGALHAACQV	SOD3	51	P08294
LDGAFTEENRAQCRA	TLN1	1546	Q9Y490
ASAEQQEAVCVVRTG	SPOCD1	336	Q6ZMY3
ADLQRFQRDCGDASQ	USP29	601	Q9HBJ7
DNIEVGICNEAGFRR	PSMA2	206	P25787
QGAQEESRCQRCISE	PLEC	1111	Q15149
QEAREGTQGERCAVH	TRIM21	81	P19474
FATVSNREQEDLCRG	ZNFX1	466	Q9P2E3
GNRREQALEELVACA	UBAP1L	366	F5GYI3
VDRSVENCVRACQAA	TLN2	746	Q9Y4G6
SIDGINRCIRDIEQA	TLN2	1666	Q9Y4G6
VAAGNSCRQEDVIAT	TLN2	2191	Q9Y4G6
VAEDNVNELRCGSVN	ZNF462	36	Q96JM2
QGTRERLAQAECVLE	TRIM73	216	Q86UV7
AQSRCGEEIAVQFVD	PHGDH	291	O43175
ANISQAARERDCESV	GTF3C1	1966	Q12789
QGTRERLAQAECVLE	TRIM50	216	Q86XT4
DRLQDSGTFQCVARD	PTK7	91	Q13308
VNEVQASGVELLCDR	TRIO	856	O75962
AIEGQTVRDQAQRCS	VPS13D	2006	Q5THJ4
ETLCNIDDRDGNRNV	L1TD1	176	Q5T7N2
CAARRQARIDSGSEV	MMUT	471	P22033