Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongroup III metabotropic glutamate receptor activity

GRM6 GRM7

1.48e-0441002GO:0001642
GeneOntologyMolecularFunctionsingle-stranded DNA helicase activity

MCM6 CHTF8 CHTF18

2.01e-04231003GO:0017116
GeneOntologyMolecularFunctionDNA helicase activity

MCM6 RUVBL2 CHTF8 CHTF18

2.64e-04621004GO:0003678
GeneOntologyMolecularFunctionglutamate receptor activity

GRIN2A GRM6 GRM7

3.27e-04271003GO:0008066
GeneOntologyBiologicalProcessdetection of mechanical stimulus

GRIN2A PJVK PKD1 SCN10A STRC STRCP1

1.62e-0675996GO:0050982
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

GRIN2A PJVK SCN10A STRC STRCP1

7.90e-0657995GO:0050974
GeneOntologyBiologicalProcessdetection of external stimulus

GRIN2A GRM6 PJVK PKD1 SCN10A STRC STRCP1

2.01e-05173997GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

GRIN2A GRM6 PJVK PKD1 SCN10A STRC STRCP1

2.17e-05175997GO:0009582
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

FAT4 PJVK STRC USH2A STRCP1

9.95e-0596995GO:0060113
GeneOntologyBiologicalProcessinner ear receptor cell stereocilium organization

FAT4 PJVK STRC STRCP1

1.22e-0453994GO:0060122
GeneOntologyBiologicalProcessmechanoreceptor differentiation

FAT4 PJVK STRC USH2A STRCP1

1.45e-04104995GO:0042490
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

GRIN2A GRM7 PJVK SCN10A STRC USH2A STRCP1

1.51e-04238997GO:0050954
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of sound

PJVK STRC STRCP1

1.77e-0423993GO:0050910
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRIN2A GRM6 GRM7 TIAM1

1.86e-0459994GO:0007215
GeneOntologyBiologicalProcessresponse to mechanical stimulus

GRIN2A PTCH1 PJVK PKD1 SCN10A STRC STRCP1

1.89e-04247997GO:0009612
GeneOntologyBiologicalProcesssensory organ development

FAT4 CYP26B1 MYOM1 GRM6 FREM2 LIM2 FAT1 PJVK MYOM2 STRC USH2A STRCP1

1.95e-047309912GO:0007423
GeneOntologyBiologicalProcesspositive regulation of glycogen metabolic process

INSR PHKA1 INS-IGF2

2.02e-0424993GO:0070875
GeneOntologyBiologicalProcessextraocular skeletal muscle development

MYOM1 MYOM2

2.26e-045992GO:0002074
GeneOntologyBiologicalProcessdendritic spine organization

CUX2 INSR GRIN2A TIAM1 INS-IGF2

2.33e-04115995GO:0097061
GeneOntologyBiologicalProcessresponse to wounding

GPR4 EPPK1 WDR83 EVPL GRIN2A BNIP3 FIBP PARD3 HPS5 INS-IGF2 VAV2

3.21e-046599911GO:0009611
GeneOntologyCellularComponent9+2 non-motile cilium

TIAM1 STRC STRCP1

3.61e-0514993GO:0097732
GeneOntologyCellularComponentkinocilium

TIAM1 STRC STRCP1

3.61e-0514993GO:0060091
GeneOntologyCellularComponentstereocilium bundle

TIAM1 PJVK STRC USH2A STRCP1

3.67e-0579995GO:0032421
GeneOntologyCellularComponentstereocilium

PJVK STRC USH2A STRCP1

3.23e-0469994GO:0032420
GeneOntologyCellularComponentsomatodendritic compartment

DIP2B ANK3 INSR GRIN2A PTCH1 CPNE5 GRM6 GRM7 NPTN BNIP3 TIAM1 PJVK PARD3 USH2A HNRNPR

6.46e-0412289915GO:0036477
Domainfn3

COL7A1 MYOM1 INSR ROS1 MYOM2 USH2A

2.12e-04162986PF00041
DomainCadherin

FAT4 PCDHA7 FREM3 FREM2 FAT1

3.93e-04118985IPR002126
Domain-

EPPK1 EVPL

4.03e-0469823.90.1290.10
DomainFN3

COL7A1 MYOM1 INSR ROS1 MYOM2 USH2A

4.31e-04185986SM00060
DomainPlectin_repeat

EPPK1 EVPL

5.63e-047982IPR001101
DomainPlectin

EPPK1 EVPL

5.63e-047982PF00681
DomainPLEC

EPPK1 EVPL

5.63e-047982SM00250
DomainFN3

COL7A1 MYOM1 INSR ROS1 MYOM2 USH2A

6.33e-04199986PS50853
DomainCalx_beta

FREM3 FREM2

7.48e-048982SM00237
DomainGPCR_3_mtglu_rcpt

GRM6 GRM7

7.48e-048982IPR000162
DomainFN3_dom

COL7A1 MYOM1 INSR ROS1 MYOM2 USH2A

8.18e-04209986IPR003961
DomainANF_lig-bd_rcpt

GRIN2A GRM6 GRM7

9.56e-0437983IPR001828
DomainANF_receptor

GRIN2A GRM6 GRM7

9.56e-0437983PF01094
DomainCalx_beta

FREM3 FREM2

9.58e-049982IPR003644
DomainCalx-beta

FREM3 FREM2

9.58e-049982PF03160
DomainLAM_G_DOMAIN

FAT4 FAT1 USH2A

1.03e-0338983PS50025
DomainPeripla_BP_I

GRIN2A GRM6 GRM7

1.12e-0339983IPR028082
DomainAmino_oxidase

MAOA SMOX

1.19e-0310982IPR002937
DomainAmino_oxidase

MAOA SMOX

1.19e-0310982PF01593
DomainLaminin_G_2

FAT4 FAT1 USH2A

1.20e-0340983PF02210
DomainTyr_kinase_rcpt_2_CS

INSR ROS1

1.45e-0311982IPR002011
DomainLamG

FAT4 FAT1 USH2A

1.59e-0344983SM00282
DomainRECEPTOR_TYR_KIN_II

INSR ROS1

1.74e-0312982PS00239
DomainNCD3G

GRM6 GRM7

2.05e-0313982PF07562
DomainGPCR_3_9-Cys_dom

GRM6 GRM7

2.05e-0313982IPR011500
Domain6-hairpin_glycosidase-like

PHKA1 AGL

2.05e-0313982IPR008928
DomainGPCR_3_CS

GRM6 GRM7

2.38e-0314982IPR017979
DomainCA

FAT4 PCDHA7 FREM2 FAT1

3.16e-03115984SM00112
Domain-

MAOA MTO1 SMOX

3.17e-03569833.50.50.60
DomainFAD/NAD-binding_dom

MAOA MTO1 SMOX

3.34e-0357983IPR023753
DomainC1_1

MYO9B CHN2 VAV2

3.34e-0357983PF00130
DomainLaminin_G

FAT4 FAT1 USH2A

3.51e-0358983IPR001791
DomainZF_DAG_PE_1

MYO9B CHN2 VAV2

4.63e-0364983PS00479
DomainZF_DAG_PE_2

MYO9B CHN2 VAV2

4.63e-0364983PS50081
DomainC1

MYO9B CHN2 VAV2

4.84e-0365983SM00109
DomainPE/DAG-bd

MYO9B CHN2 VAV2

5.05e-0366983IPR002219
Pubmed

Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.

COL7A1 FREM3 FREM2

2.30e-075100317251066
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SIN3B FAT4 CYP26B1 EVPL FREM2 FBXL7 GTF3C1 H4C1 DROSHA AGL PKD1 HNRNPR

1.42e-067361001229676528
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

MYO9B CHN2 TIAM1 VAV2

4.41e-0638100419911011
Pubmed

Protein kinase D activation stimulates the transcription of the insulin receptor gene.

INSR PKD1

8.18e-062100220674666
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

8.18e-062100234910522
Pubmed

Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.

INSR CHN2

8.18e-062100219720790
Pubmed

Tetrodotoxin-resistant voltage-gated sodium channel Nav 1.8 constitutively interacts with ankyrin G.

ANK3 SCN10A

8.18e-062100224903831
Pubmed

The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity.

TIAM1 PARD3

8.18e-062100217825562
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

8.18e-062100211687802
Pubmed

Par3 regulates invasion of pancreatic cancer cells via interaction with Tiam1.

TIAM1 PARD3

8.18e-062100226084985
Pubmed

Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.

FAT4 FAT1 PARD3

1.82e-0518100326209645
Pubmed

Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps.

INSR INS-IGF2

2.45e-053100234282152
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRC STRCP1

2.45e-053100230801007
Pubmed

Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.

INSR INS-IGF2

2.45e-053100229512653
Pubmed

Replication of genetic variation in the MYO9B gene in Crohn's disease.

MYO9B PARD3

2.45e-053100221515326
Pubmed

Alternative splicing variants of proinsulin mRNA and the effects of excess proinsulin on cardiac morphogenesis.

INSR INS-IGF2

2.45e-053100223747309
Pubmed

Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability.

MYO9B PARD3

2.45e-053100220096742
Pubmed

Mutations in the C1 element of the insulin promoter lead to diabetic phenotypes in homozygous mice.

INSR INS-IGF2

2.45e-053100232546815
Pubmed

All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.

INSR INS-IGF2

2.45e-053100223348915
Pubmed

Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration.

ANK3 TIAM1

2.45e-053100210893266
Pubmed

The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins.

MYOM1 MYOM2

2.45e-05310027505783
Pubmed

Expression of Fraser syndrome genes in normal and polycystic murine kidneys.

FREM3 FREM2

2.45e-053100221993971
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

EPPK1 PFAS MCM6 CCT4 GMPR2 RUVBL2 GTF3C1 AGL POLR1B TBC1D23

3.65e-057041001029955894
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIN2A GRM6 GRM7

4.47e-0524100335746896
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRC STRCP1

4.89e-054100218849963
Pubmed

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

TIAM1 VAV2

4.89e-054100212810717
Pubmed

Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice.

MYOM1 MYOM2

4.89e-054100210438587
Pubmed

Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.

FREM3 FREM2

4.89e-054100218563433
Pubmed

Distribution of group-III metabotropic glutamate receptors in the retina.

GRM6 GRM7

4.89e-054100217311335
Pubmed

Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.

FREM3 FREM2

4.89e-054100224101214
Pubmed

Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation.

INSR INS-IGF2

4.89e-054100226511317
Pubmed

Arteries define the position of the thyroid gland during its developmental relocalisation.

FOXE1 PTCH1

4.89e-054100216968815
Pubmed

Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein.

MYOM1 MYOM2

4.89e-054100212972258
Pubmed

Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.

INSR INS-IGF2

4.89e-054100226573296
Pubmed

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.

INSR INS-IGF2

4.89e-054100235136059
Pubmed

A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity.

CHTF8 CHTF18

4.89e-054100217545166
Pubmed

The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.

TIAM1 PARD3

4.89e-054100219893486
Pubmed

Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.

TIAM1 PARD3

4.89e-054100215723052
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

TRA2B MYO9B INSR PFAS MCM6 CCT4 RUVBL2 ERAP2 H4C1 CHTF18 DOT1L PARD3 HNRNPR

6.00e-0512471001327684187
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

ISYNA1 TRA2B FBXL12 PFAS MCM6 CCT4 RUVBL2 GTF3C1 H4C1 CHTF18 AGL POLR1B HNRNPR

6.50e-0512571001337317656
Pubmed

Myomesin 3, a novel structural component of the M-band in striated muscle.

MYOM1 MYOM2

8.14e-055100218177667
Pubmed

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.

INSR INS-IGF2

8.14e-055100218056790
Pubmed

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.

INSR INS-IGF2

8.14e-055100215924147
Pubmed

Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly.

FAT4 FAT1

8.14e-055100230862798
Pubmed

Insulin signaling to the glomerular podocyte is critical for normal kidney function.

INSR INS-IGF2

8.14e-055100220889126
Pubmed

Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors.

TIAM1 VAV2

8.14e-055100215479739
Pubmed

Genetic risk for restenosis after coronary stenting.

INSR ROS1

8.14e-055100217275003
Pubmed

Selective gene activation by spatial segregation of insulin receptor B signaling.

INSR INS-IGF2

8.14e-055100217264162
Pubmed

Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal.

INSR INS-IGF2

8.14e-055100228931726
Pubmed

Glucose, insulin, insulin receptor subunits α and β in normal and spontaneously diabetic and obese ob/ob and db/db infertile mouse testis and hypophysis.

INSR INS-IGF2

8.14e-055100232183843
Pubmed

The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells.

INSR INS-IGF2

8.14e-055100223886629
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

STRC STRCP1

8.14e-055100224920589
Pubmed

Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.

FREM3 FREM2

8.14e-055100217596926
Pubmed

Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.

COL7A1 MYOM1 MYOM2

9.78e-0531100322282597
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DIP2B PFAS RUVBL2 FREM2 GTF3C1 DROSHA CHTF18 ANAPC2 HPS5

1.11e-04650100938777146
Pubmed

Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.

GRM6 GRM7

1.22e-046100216144832
Pubmed

Establishment of cardiac cytoarchitecture in the developing mouse heart.

MYOM1 MYOM2

1.22e-046100216337936
Pubmed

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.

GRIN2A SMOX

1.22e-046100223665428
Pubmed

Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population.

FOXE1 EVPL

1.22e-046100227207655
Pubmed

Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.

FREM3 FREM2

1.22e-046100217462874
Pubmed

Central insulin action regulates peripheral glucose and fat metabolism in mice.

INSR INS-IGF2

1.22e-046100218451994
Pubmed

Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.

INSR MCM6 CCT4 RUVBL2 H4C1 HNRNPR

1.31e-04269100630442662
Pubmed

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.

PTCH1 FREM3 FREM2 PKD1

1.68e-0495100420843830
Pubmed

Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8.

CHTF8 CHTF18

1.70e-047100220826785
Pubmed

Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.

FAT4 FAT1

1.70e-047100222510986
Pubmed

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

INSR INS-IGF2

1.70e-04710021317321
Pubmed

Autoreactive T-cell receptor (Vbeta/D/Jbeta) sequences in diabetes are homologous to insulin, glucagon, the insulin receptor, and the glucagon receptor.

INSR INS-IGF2

1.70e-047100219051206
Pubmed

Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.

GRM6 GRM7

1.70e-04710029920659
Pubmed

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

FAT4 FAT1

1.70e-047100216059920
Pubmed

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

INSR INS-IGF2

1.70e-047100212488434
Pubmed

Expression of genes for insulin and insulin-like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells.

INSR INS-IGF2

1.70e-04710021701096
Pubmed

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis.

PKD1 PARD3

1.70e-047100224153433
Pubmed

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

INSR INS-IGF2

1.70e-047100228687614
Pubmed

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

DIP2B MAOA ANK3 CCT4 RUVBL2 H4C1 AGL FIBP

2.13e-04558100835063084
Pubmed

Bimodal distribution of RNA expression levels in human skeletal muscle tissue.

MAOA ERAP2

2.27e-048100221299892
Pubmed

CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

TIAM1 PARD3

2.27e-048100220332120
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

STRC STRCP1

2.27e-048100221165971
Pubmed

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas.

PTCH1 INS-IGF2

2.27e-04810029368764
Pubmed

Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2.

ZAP70 VAV2

2.27e-048100211390470
Pubmed

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.

MYOM1 MYOM2

2.27e-048100220215401
Pubmed

PHOG, a candidate gene for involvement in the short stature of Turner syndrome.

SHOX GABPB2

2.27e-04810029259282
Pubmed

Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.

TIAM1 PKD1

2.27e-048100225907116
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

ISYNA1 EPPK1 ANK3 RUVBL2 PHKA1 VAV2

2.54e-04304100632235678
Pubmed

Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.

TRA2B FBXL12 MCM6 FBXL7 ANAPC2 HPS5 ATP6V0A2

2.58e-0443210077671812
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

MYO9B INSR PTCH1 DOT1L SMOX

2.76e-04198100520881960
Pubmed

In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice.

INSR INS-IGF2

2.91e-049100211159375
Pubmed

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

PTCH1 PARD3

2.91e-049100223446420
Pubmed

The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun.

FBXL12 FBXL7

2.91e-049100217704768
Pubmed

Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.

INSR ROS1

2.91e-049100211094073
Pubmed

Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas.

EPPK1 INS-IGF2

2.91e-049100218498355
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

GRIN2A GRM6 GRM7

3.00e-0445100325979088
Pubmed

SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.

CCT4 RUVBL2 H4C1

3.20e-0446100329969578
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

FAT4 EPPK1 TRA2B PFAS TMEM214 RUVBL2 FBXL7 ROS1 VAV2

3.32e-04754100935906200
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

DIP2B TRA2B ATP13A1 PFAS DROSHA SSH3 CHTF18 AGL PKD1 POLR1B

3.37e-049251001028986522
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA4B EPPK1 ATP13A1 MYO9B FBXL12 PFAS PTCH1 ABCA7 FAT1 PKD1 DOT1L

3.40e-0411051001135748872
Pubmed

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

RUVBL2 GTF3C1 ANAPC2 HNRNPR

3.60e-04116100421549307
Pubmed

Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.

FOXE1 DHRS1

3.63e-0410100224571439
Pubmed

Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis.

CCT4 RUVBL2

3.63e-0410100235821088
Pubmed

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development.

PTCH1 INS-IGF2

3.63e-0410100231116975
Pubmed

Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.

RUVBL2 GTF3C1

3.63e-0410100219299493
InteractionPHKG2 interactions

PLEKHA4 PEX10 PHKA1 TIAM1 AGL HPS5

5.41e-0691986int:PHKG2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

SIN3B SLC25A42 ISYNA1 ATP13A1 MYO9B INSR FBXL12 WDR83 ABCA7 DOT1L

9.98e-0679710010chr19p13
Cytoband19p13.11

SIN3B SLC25A42 ISYNA1 ATP13A1

2.06e-0573100419p13.11
GeneFamilyFibronectin type III domain containing

COL7A1 MYOM1 INSR ROS1 MYOM2 USH2A

4.22e-05160726555
GeneFamilyFibronectin type III domain containing|I-set domain containing|Myosin binding proteins

MYOM1 MYOM2

4.31e-048722658
GeneFamilyEF-hand domain containing|Plakins

EPPK1 EVPL

4.31e-048722939
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM6 GRM7

4.31e-048722281
GeneFamilyCadherin related

FAT4 FAT1

2.05e-031772224
GeneFamilyF-box and leucine rich repeat proteins

FBXL12 FBXL7

3.13e-0321722558
CoexpressionJAEGER_METASTASIS_DN

COL7A1 EPPK1 CYP26B1 ANK3 EVPL PTCH1 CHN2 SSH3

7.13e-062601008M10702
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FAT4 DOK2 HAVCR2 LIM2 GTF3C1 SSH3 MYOM2

3.15e-071971007d2f7ba404a0340e12ccbd3f9d76c8d782584e775
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP26B1 GRIN2A FREM2 SCN10A STRC SLC2A12

1.55e-061581006f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP26B1 GRIN2A FREM2 SCN10A STRC SLC2A12

1.55e-0615810068c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCelldroplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOM1 MCM6 CPNE5 HAVCR2 CHTF18 PADI1

3.09e-061781006de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FREM2 FAT1 ROS1 MYOM2 USH2A

3.74e-0618410062cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FREM2 FAT1 ROS1 MYOM2 USH2A

3.74e-061841006ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FREM2 FAT1 ROS1 MYOM2 USH2A

3.74e-0618410062b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.06e-061941006fa72c2f3e6b8bfc2ef126deb219ec6a44809385b
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.06e-061941006bc7c4efe2a82057fb95582da983e36f413990902
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.06e-061941006b43788e458a80ab93f485f4577370aec448ad95e
ToppCellIIF-Lymphocyte-T_NK-NK|IIF / Disease, Lineage and Cell Type

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.22e-061951006464ce05cb52f78aee22d3baa6641b37bd53aae16
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.22e-061951006acc603dc94ac6518adb0dffb43305b380ec75b52
ToppCellT/NK_cells-CD56dim_NK_cell|World / Lineage and Cell class

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.22e-0619510066124e87cb9061bf8918377fb4a79084079ddfc16
ToppCellnormal-na-Lymphocytic_NK|normal / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.22e-061951006cebe79c42af5910353ba9ad7d0edb01982f772a3
ToppCell(0)_NK_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-0619610069b080859130cf156bfa833dc71fd39734cb9a32d
ToppCellCOVID-19_Severe-Lymphoid_T/NK-NK|COVID-19_Severe / Disease group, lineage and cell class

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-061961006cc1daf12de5765ba4f7002396352404b41df2012
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-061961006d3bd8fab010e76024d7e06aba0ea5df3394f411f
ToppCell(0)_NK|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-061961006e2578a562d9903a33a7c60db229005680af8141c
ToppCellnormal-na-Lymphocytic_NK-NK_dim-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-06196100661bc0d161e01f36e5bcda4d4f4693afbfe5654bb
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-06196100677da6b1bcab45d376eb0368f540e0ed24ce98b42
ToppCelltumor_Lung-T/NK_cells-NK|tumor_Lung / Location, Cell class and cell subclass

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-061961006006e630f3d8033f45c6b7e9154d77000c7b0cb70
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-061961006c25f90c4e5abfe7cfaa85bfe136c438a5179c978
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-061961006d451f279f4086fcf727af712f98923551181c76e
ToppCellnormal-na-Lymphocytic_NK-NK_dim|normal / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.37e-0619610063360d96dc06241498995bcb875615bd4c1424f5a
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.53e-0619710069993fdea353abeafc009ac87439ad25cedf8f1f6
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.53e-061971006300849a922722adcbc068593fc5cc0bef936d9cb
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.53e-061971006a8b41fffa4e86f2766423392951ff320e821a19a
ToppCellT/NK_cells-CD56dim_NK_cell|T/NK_cells / Lineage and Cell class

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.53e-061971006722d00a218755cc8cb7b5ab2a7fca40269247c3a
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.53e-061971006a97c4a9eb89260b0b5745834ccef9d558d857f93
ToppCell(0)_NK_FCGR3Apos|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.69e-06198100613f10f9233fc1523f0da2d9d59f3ced9c51a603a
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B|390C / Donor, Lineage, Cell class and subclass (all cells)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.69e-0619810060dc4a564dcab8ac42f238f98ee1f2090b0dcffe6
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-NK|Multiple_Sclerosis / Disease, Lineage and Cell Type

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.69e-061981006d413020012977eb8da0a5641dd16d0b0a60bec38
ToppCell(0)_NK_cells-(0)_NK_FCGR3Apos|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

PTCH1 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.69e-061981006eba39656c6f699ab297b652ded8cb9727b49593c
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAT4 DOK2 ZAP70 HAVCR2 LIM2 MYOM2

5.69e-0619810061a189b2b213099505c5d871fb8aedd55a97d44e0
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAT4 DOK2 ZAP70 HAVCR2 LIM2 MYOM2

5.69e-061981006716c27d2a37b5f865b9d191e1851917340b400af
ToppCell390C-Lymphocytic-NK_cells|390C / Donor, Lineage, Cell class and subclass (all cells)

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.69e-061981006872ddb2738c5e0375830bb0e5b2c50383bf58738
ToppCellmetastatic_Lymph_Node-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

5.69e-061981006cc4c1306683b801c1cb0adc01951aa6e3d73626f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAT4 DOK2 ZAP70 HAVCR2 LIM2 MYOM2

5.69e-061981006b12914c3c5b8dd628cb456cb40283c5016641872
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL7A1 CUX2 FREM2 TIAM1 PARD3 VAV2

6.03e-062001006f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellMS-IIF-Lymphocyte-T/NK-NK|IIF / Disease, condition lineage and cell class

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

6.03e-0620010064f889cc5ab76a128fd781d927b0d8368f4f927b7
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL7A1 CUX2 FREM2 TIAM1 PARD3 VAV2

6.03e-06200100670a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellsevere-NK|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

6.03e-06200100664e8a6c36e0c654b7b2416c9f19b9058215222b1
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK|COVID-19_Severe / Disease, condition lineage and cell class

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

6.03e-0620010062580b7b83ba707718fe23ffca986e7a55ea85bce
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-NK|Multiple_Sclerosis / Disease, condition lineage and cell class

DOK2 ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

6.03e-062001006d7a611d88107d84b5995b353e8cf95c6a7eb79de
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL7A1 CUX2 FREM2 TIAM1 PARD3 VAV2

6.03e-0620010061639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCelldistal-Epithelial-Basal-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FOXE1 SEMA4B COL7A1 ISYNA1 PLEKHA4 PNCK

6.03e-0620010066f00d08e93f89b3575ebbd5c2f451e655d449ef3
ToppCellBLOOD--(0)_NK_cell-(0)_NK_cells_(CD56dim-like)|(0)_NK_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DOK2 ZAP70 HAVCR2 GTF3C1 MYOM2

1.91e-0514510056dd81d53d006fcc206a10969374a11c372f92133
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-3|TCGA-Colorectal / Sample_Type by Project: Shred V9

WDR83 PEX10 RUVBL2 ANAPC2 NAGPA

3.45e-051641005201aee6387e69f918d87fa87d9b5b2ab3b305f61
ToppCelldroplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPR4 GMPR2 TIAM1 H4C1 DOT1L

3.65e-051661005de319c960b0cd90b294f677d1ea1b013a2ce2d53
ToppCellNS-critical-d_0-4-Epithelial-unknown_epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EPPK1 PLEKHA4 FBXL7 H4C1 PNCK

3.65e-051661005dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ISYNA1 ANK3 ZAP70 MYOM2 DNAJC5B

4.45e-0517310055295ed31648abf8edff214cf67cd4769f20f9e6d
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK-T_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PRSS33 DOK2 ZAP70 HAVCR2 LIM2

5.37e-0518010050a98d21fec67a890e75ebf0e2d23adddd77da214
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PRSS33 DOK2 ZAP70 HAVCR2 LIM2

5.37e-0518010051c8398342d3fa4d5ca9a8a63626cc497c5291446
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK-T_NK-CD56_bright_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PRSS33 DOK2 ZAP70 HAVCR2 LIM2

5.37e-051801005ddbab26b05f057bd78b78773381cd447bd2e2726
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

CUX2 INSR GRIN2A GRM7 USH2A

5.51e-051811005c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellControl-Epithelial-Basal|World / Disease state, Lineage and Cell class

FOXE1 COL7A1 ANK3 FAT1 PARD3

5.66e-051821005759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B2|356C / Donor, Lineage, Cell class and subclass (all cells)

DOK2 ZAP70 LIM2 GTF3C1 MYOM2

5.66e-05182100552baef8173df0a55307c375674a37c2488066738
ToppCellControl-Epithelial-Basal|Control / Disease state, Lineage and Cell class

FOXE1 COL7A1 ANK3 FAT1 PARD3

5.66e-051821005caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

FOXE1 DIP2B COL7A1 TRA2B PNCK

5.96e-051841005ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCellMild_COVID-19-Epithelial-AT1/AT2|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

MAOA FREM2 FAT1 CLCNKA SLC2A12

6.11e-051851005c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCellIPF-Epithelial-ATII|World / Disease state, Lineage and Cell class

MAOA ANK3 FREM2 ROS1 PARD3

6.27e-0518610056a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

6.59e-051881005a29c43a91ed1364a09d5abab6efa51b8061bce74
ToppCellCOPD-Epithelial-ATII|COPD / Disease state, Lineage and Cell class

MAOA ANK3 FREM2 ROS1 PARD3

6.59e-051881005eb6d79d733b53f64ca615bb777c64ed456866549
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ANK3 GRIN2A PTCH1 FREM2 FBXL7

6.59e-051881005b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 FAT1 FBXL7 TIAM1 PARD3

6.93e-0519010052f54da2bee411f8868348a4c37034184b8f58a89
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

ANK3 MYOM1 CPNE5 FAT1 MYOM2

6.93e-05190100593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

ANK3 MYOM1 CPNE5 CHN2 MYOM2

6.93e-051901005fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

MAOA ANK3 FREM2 ROS1 PARD3

7.28e-0519210051bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTCH1 ZAP70 LIM2 GTF3C1 MYOM2

7.28e-051921005ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTCH1 ZAP70 LIM2 GTF3C1 MYOM2

7.28e-05192100558a7829b411b02b422ef75e2277a868969cc23e8
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

7.28e-051921005fd7f034f0d5a5d577dc9e26a15856f5defbdef43
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

7.28e-0519210051922b0350d3375e67c314dbce8074e5cf986f2ef
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

7.28e-05192100597c197643e59835c6d45dde9e549c9a1b1bb7288
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

7.28e-051921005a4d161e3d48bc020e687808b352325ef9d1cc1f3
ToppCell3'_v3-bone_marrow-Lymphocytic_NK|bone_marrow / Manually curated celltypes from each tissue

DOK2 ZAP70 HAVCR2 GTF3C1 MYOM2

7.46e-051931005e790ab76c12f74a13936c231076f1e397283efb3
ToppCellICU-SEP-Lymphocyte-T_NK-NK|ICU-SEP / Disease, Lineage and Cell Type

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

7.46e-051931005f110f86db305e41639087f5b1a2dff103c07adf0
ToppCelllymphoid-NK_cell-NK_cell|World / Lineage, cell class and subclass

DOK2 HAVCR2 LIM2 GTF3C1 MYOM2

7.65e-0519410057f5adc18e632109694446b8eb1543cbae62dccbe
ToppCell3'_v3-bone_marrow-Lymphocytic_NK-NK_CD16|bone_marrow / Manually curated celltypes from each tissue

DOK2 ZAP70 HAVCR2 GTF3C1 MYOM2

7.65e-0519410057773501e076d470158dbc1d7f10c67152b326eb7
ToppCelllymphoid-NK_cell|World / Lineage, cell class and subclass

DOK2 HAVCR2 LIM2 GTF3C1 MYOM2

7.65e-0519410054bf5a140be8691e4ec99d7ee15588fd48acd6fb5
ToppCell343B-Lymphocytic-NK_cells|343B / Donor, Lineage, Cell class and subclass (all cells)

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

7.83e-05195100533a460624a65ba033452c74d143089e0bfac8f3d
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

7.83e-05195100572f42f0be53a2a61f61647118b4883e752d998a5
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

EPPK1 ZNF165 EVPL FREM2 ROS1

7.83e-05195100562d369a8af2b76a2553bc8ff9cb89a133b060123
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

7.83e-05195100549a4f58aac168fc1838bd5d2b202135cd794c28b
ToppCellwk_20-22-Hematologic_Lymphocytic-NK-CD16+_NK|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

7.83e-0519510057533822d2fe551f499b5b2fdec7172f56c79cb44
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_NK-NK_CD16|lymph-node_spleen / Manually curated celltypes from each tissue

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

7.83e-051951005e756733cf48768bf40058d6cf9039e52f7563133
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

8.03e-0519610055b5cf6f70534661d694f47359b6595b4580876c3
ToppCelllymphoid-NK_cell-NK_cell|lymphoid / Lineage, cell class and subclass

DOK2 HAVCR2 LIM2 GTF3C1 MYOM2

8.03e-0519610055e6238fe131e349013c60a73c99f84a6be7955ef
ToppCell10x5'-bone_marrow-Lymphocytic_NK-NK_CD16|bone_marrow / Manually curated celltypes from each tissue

DOK2 ZAP70 HAVCR2 GTF3C1 MYOM2

8.03e-051961005a3b077e82b1550eb328c84b567b60179001f9a77
ToppCell10x5'-bone_marrow-Lymphocytic_NK|bone_marrow / Manually curated celltypes from each tissue

DOK2 ZAP70 HAVCR2 GTF3C1 MYOM2

8.03e-0519610051868ad537b7f04cdad0a0c8282aadbc4f257a722
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZAP70 HAVCR2 LIM2 GTF3C1 MYOM2

8.22e-05197100576304df40f87224f8e415677e3ee8fb183fe0c03
ToppCell356C-Lymphocytic-NK_cells|356C / Donor, Lineage, Cell class and subclass (all cells)

DOK2 ZAP70 HAVCR2 GTF3C1 MYOM2

8.22e-051971005ae55ac5c714e55061d605dee030cbe29b43cf9c1
ToppCellnormal-na-Lymphocytic_NK-natural_killer_cell-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

8.22e-051971005994d3289a5dd1a89fbcf28a6263e3784ccf732df
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAT4 ZAP70 HAVCR2 LIM2 MYOM2

8.22e-051971005bc37b8919f98dc18c2200834405f06823d965d78
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOK2 PTCH1 ZAP70 GTF3C1 MYOM2

8.22e-0519710052abe27f6722fa0dab801bca4cd19e34c1fb4173e
ToppCellBLOOD--(0)_NK_cell| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

8.22e-051971005ce35c3ba6db897235d0107fa7dadc5013bf4da24
ToppCellBLOOD--(0)_NK_cells_(CD56dim-like)| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

8.22e-0519710054c15b3386b89191af9332738e597549e2305de26
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DOK2 ZAP70 HAVCR2 GTF3C1 MYOM2

8.22e-051971005c7cd7960e8f022b1db49485ff153675827efa35e
ToppCellnormal-na-Lymphocytic_NK-natural_killer_cell|normal / PBMC cell types (v2) per disease, treatment status, and sex

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

8.22e-05197100573a33d8b27043ba3074d04bc2d18cd287e00117f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOK2 ZAP70 HAVCR2 LIM2 MYOM2

8.22e-051971005b6689a3e01e4c285fc2cb33f8c437078722a3892
ToppCellHealthy_donor-NK|World / disease group, cell group and cell class (v2)

DOK2 ZAP70 LIM2 GTF3C1 MYOM2

8.42e-0519810054c9c40e91173836ad0df2eba635a4cb3385e80c6
Diseasesexual dimorphism measurement

DIP2B COL7A1 EPPK1 TRA2B KCTD19 ZNF165 MYO9B INSR GRIN2A PTCH1 H4C1 PKD1 DOT1L SMOX INS-IGF2 ATP6V0A2

8.29e-0711069916EFO_0021796
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

1.11e-052992DOID:0110471 (implicated_via_orthology)
Diseasevital capacity

DIP2B CYP26B1 PCDHA7 GRIN2A GMPR2 PTCH1 GRM7 IVD GABPB2 H4C1 DOT1L PARD3 SMOX SLC2A12

6.51e-0512369914EFO_0004312
Diseasebrain disease (implicated_via_orthology)

TIAM1 DROSHA

1.66e-046992DOID:936 (implicated_via_orthology)
Diseaseneutrophil count

CUX2 ATP13A1 PCDHA7 MCM6 DOK2 ABCA7 DEFA5 LIM2 BNIP3 GTF3C1 GABPB2 ERAP2 PKD1 ATP6V0A2

2.09e-0413829914EFO_0004833
Diseaselung volume

TRA2B PTCH1

3.08e-048992EFO_0600046
Diseasesupraventricular ectopy

KIF6 SCN10A

3.95e-049992EFO_0009277
Diseaseheart rate response to exercise

CPNE5 SCN10A SMOX

4.10e-0443993EFO_0009184
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

SIN3B GRIN2A PARD3

6.03e-0449993DOID:0060037 (implicated_via_orthology)
Diseasemyeloid white cell count

ATP13A1 MCM6 ABCA7 DEFA5 GTF3C1 PKD1 POLR1B DOT1L DNAJC5B VAV2

1.21e-039379910EFO_0007988
DiseaseGlycogen storage disease

PHKA1 AGL

1.47e-0317992cv:C0017919
DiseaseDepression, Bipolar

MAOA ANK3 GRIN2A

2.41e-0379993C0005587
DiseaseMood Disorders

MAOA ANK3 GRIN2A SMOX

2.51e-03168994C0525045
Diseasecolorectal cancer, hormone replacement therapy

CUX2 TRA2B INSR

3.27e-0388993EFO_0003961, MONDO_0005575

Protein segments in the cluster

PeptideGeneStartEntry
TSTEGVRAYLVLRAD

CHTF18

181

Q8WVB6
RRSSDIISLLVSIYG

ANAPC2

496

Q9UJX6
LGRETGTRYLVTALI

CHTF8

86

P0CG13
TEISREGARVLALGY

ATP13A1

676

Q9HD20
IVDRYSGDLRVASAL

FAT4

1576

Q6V0I7
RERAYGSSGELITSL

DOT1L

851

Q8TEK3
LKRRYGLISTGSDSE

CUX2

1131

O14529
RTLSTTGEALYEILG

DNAJC5B

11

Q9UF47
DTRLAELRLTGYGIS

ABCA7

1121

Q8IZY2
GRSVLYLTGVDISLE

PADI1

106

Q9ULC6
EYRTTRVSREGGVLK

ISYNA1

26

Q9NPH2
TGGVLIDRYGRRTAI

SLC2A12

96

Q8TD20
RIESTLDGSRLYITG

KCTD19

306

Q17RG1
TGITYLRVRSLPGED

PEX10

196

O60683
VLEARDRVGGRTYTI

MAOA

41

P21397
SYSLVELRVGERALS

PCDHA7

491

Q9UN72
SGVIVLTGRLDYLET

FAT1

201

Q14517
YETEGIRGLRALGVR

MCM6

276

Q14566
LRGSYTLRAGESALE

DOK2

166

O60496
LAIYTGVTVSFLGRR

LIM2

116

P55344
RISGLIYEETRGVLK

H4C1

46

P62805
RTGDIALAYRLTDLG

MAP10

171

Q9P2G4
SRTEGYIGVLIDDLT

MTO1

466

Q9Y2Z2
ERSATVRELLTELYG

PHKA1

801

P46020
GTLRLDTLSGLRYLD

CYP26B1

341

Q9NR63
LKRRGYLGETSFISI

FREM2

1791

Q5SZK8
ILDSGIYRIISSRRG

HPS5

446

Q9UPZ3
GGIVDLLSRERYSVH

EVPL

1866

Q92817
LERTGYTLDVTTGQR

HNRNPR

131

O43390
VGRYLRELSGSGLER

COG8

46

Q96MW5
TGLAVESIKTVYRGR

DIP2B

831

Q9P265
TITGGAERYSDRGII

KIF6

106

Q6ZMV9
RDILGGIRSTCTYVG

GMPR2

306

Q9P2T1
GLIEEISGYLKIRRS

INSR

386

P06213
AEYRVRLGALRLGST

PRSS33

86

Q8NF86
ESLSGVCEISGRLYR

DEFA5

76

Q01523
KLYEIGAGTSEVRRL

IVD

401

P26440
GRDARSSITGVYRII

NIM1K

376

Q8IY84
YRGILRAVRGSVSTE

GPR4

201

P46093
ISSVYEIRERLGSGA

PNCK

11

Q6P2M8
IEARGLKSEGLYRVS

CHN2

301

P52757
VRASGRELSYVLLTG

GRM6

616

O15303
AIGLGIYIGRRLTTS

BNIP3

176

Q12983
VTVSGCRRLTDRGLY

FBXL7

191

Q9UJT9
GIARRLGYISVVDTL

ANK3

801

Q12955
KSTYRTLGGETRILA

ERAP2

181

Q6P179
VRASGRELSYVLLTG

GRM7

621

Q14831
IRGLEGGVSYSVRVT

COL7A1

831

Q02388
GATVYITGRHLDTLR

DHRS1

31

Q96LJ7
GIDGILEAYHRSLRT

CPNE5

411

Q9HCH3
QGLEYRGRRVTTELV

INS-IGF2

131

F8WCM5
LVLRRGVLRDGEGYT

PKD1

2431

P98161
ERRISHSLYSGIEGL

PARD3

711

Q8TEW0
GYSVTDAVALRVRSG

FIBP

26

O43427
DRFLVGGYLSSRVLL

MIEF2

241

Q96C03
LEVTLTRRGYLGETS

FREM3

1791

P0C091
YSTAEVLLRAGVSRD

GABPB2

51

Q8TAK5
AYTVLTRIGLETSLR

RUVBL2

386

Q9Y230
SYELRRDGTIVYTGL

USH2A

4476

O75445
GDSTVVGTSRLRDLY

DROSHA

431

Q9NRR4
ERRLTLGGIYKFITE

FOXE1

71

O00358
YSGLEQELGTLRETL

PLEKHA4

451

Q9H4M7
RALRSLVLGGTYRVT

FBXL12

176

Q9NXK8
DLRDSGATIRIGIYI

HAVCR2

191

Q8TDQ0
DLLSRYRAGTLTVEE

EPPK1

3006

P58107
YRAGTLTVEELGATL

EPPK1

3011

P58107
RYRAGTLTVEELGAT

EPPK1

3541

P58107
DLLSRYRAGTLTVEE

EPPK1

4071

P58107
YRAGTLTVEELGATL

EPPK1

4076

P58107
GIRRDGTLVTGYLSE

NAGPA

171

Q9UK23
TALLLSRDGRTLYVG

SEMA4B

71

Q9NPR2
LGVSLYGTTRVRDGL

PTCH1

761

Q13635
YGTTRVRDGLDLTDI

PTCH1

766

Q13635
SLGGTSEVIQRRAIY

SIN3B

531

O75182
DSITYREVLESGLAR

SHOX

31

O15266
ELALRLTEYSRTLSG

CCT4

431

P50991
LRTIVREEGAVRGLY

SLC25A42

271

Q86VD7
EGRRSVLRTIGEYLE

STRC

666

Q7RTU9
GRVAYELLGVLRSSG

STRC

971

Q7RTU9
RYLLVVSTREGEGLS

SSH3

126

Q8TE77
IAAYLGRVRTTTIGE

CLCNKA

176

P51800
VLTSGDTLYGLAERV

VPS50

716

Q96JG6
RSLGGYVLSLVHDVR

ZAP70

41

P43403
SLSSVEEDGIRRLYV

TIAM1

861

Q13009
ILLGDREISAGISSY

PJVK

61

Q0ZLH3
YVGTAIDLRGISGLR

SCN10A

201

Q9Y5Y9
TGLGPVDRVETTRRY

PFAS

111

O15067
SSASGIEILAIERYL

TBC1D23

661

Q9NUY8
LRITRLTLEDSGTYE

NPTN

101

Q9Y639
ETTDGERSVGRISLY

SMOX

101

Q9NWM0
YSLVSRELRGIIRGL

TMEM214

171

Q6NUQ4
VSDLRIFYRGSGLIS

ROS1

356

P08922
ILAGSVDGRVRRYDL

WDR83

166

Q9BRX9
RIISGRISGYISEAS

ZNF165

206

P49910
EGRRSVLRTIGEYLE

STRCP1

666

A6NGW2
GRVAYELLGVLRSSG

STRCP1

971

A6NGW2
SLREGDVVRIYSRIG

VAV2

836

P52735
TERLYSGISGLELEA

POLR1B

976

Q9H9Y6
QTYDLIERRGTKGIS

GTF3C1

371

Q12789
ILIVGRESGTIQRYS

WDR35

516

Q9P2L0
GVFGLSLYTTERDLR

TRA2B

121

P62995
RVGLRVDTTYGVLLL

ATP6V0A2

776

Q9Y487
ALRGILLITGRYVEA

AGL

1106

P35573
ALLRGSDSSYVRELI

MYO9B

661

Q13459
VTGLIEGRSYIFRVR

MYOM1

571

P52179
GLYTLRIVSRGGVSD

MYOM2

351

P54296
YSLEARVRDGIGILT

GRIN2A

286

Q12879