Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchromatin binding

TNRC18 ZNF276 HMGA1 STAG1 NSD2 AHDC1 HP1BP3 DNTTIP1

4.03e-06739278GO:0003682
GeneOntologyMolecularFunctionDNA binding, bending

HMGA1 FOXL1

3.30e-0420272GO:0008301
DomainAT_hook

PRR12 HMGA1 AHDC1

6.85e-0627263SM00384
DomainAT_hook_DNA-bd_motif

PRR12 HMGA1 AHDC1

6.85e-0627263IPR017956
DomainAT_hook

PRR12 HMGA1

2.21e-0416262PF02178
DomainPWWP

NSD2 HDGFL2

3.49e-0420262SM00293
DomainPWWP

NSD2 HDGFL2

4.63e-0423262PF00855
DomainPWWP_dom

NSD2 HDGFL2

4.63e-0423262IPR000313
DomainPWWP

NSD2 HDGFL2

5.05e-0424262PS50812
DomainHMGI/Y_DNA-bd_CS

PRR12 HMGA1

8.45e-0431262IPR000637
DomainPHD

TCF20 NSD2

6.77e-0389262SM00249
DomainZnf_PHD

TCF20 NSD2

7.07e-0391262IPR001965
DomainZF_PHD_2

TCF20 NSD2

7.68e-0395262PS50016
DomainZF_PHD_1

TCF20 NSD2

7.84e-0396262PS01359
DomainSH2

ABL1 BCAR3

8.65e-03101262PF00017
DomainSH2

ABL1 BCAR3

1.02e-02110262SM00252
DomainSH2

ABL1 BCAR3

1.04e-02111262PS50001
DomainSH2

ABL1 BCAR3

1.05e-02112262IPR000980
Domain-

ABL1 BCAR3

1.05e-021122623.30.505.10
DomainZnf_FYVE_PHD

TCF20 NSD2

1.77e-02147262IPR011011
DomainSH3_1

ABL1 ARHGAP33

2.17e-02164262PF00018
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

PRR12 PRPF31 ZNF276 HMGA1 TCF20 NSD2 HDGFL2 AHDC1 HP1BP3 DNTTIP1

2.32e-081294271030804502
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

PRPF31 TCF20 STAG1 NSD2 HDGFL2 HP1BP3 DNTTIP1

3.16e-0760827736089195
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

PRPF31 FLNA HMGA1 NSD2 HDGFL2 HP1BP3

9.49e-0744127631239290
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PRR12 PRPF31 FLNA TNRC18 HMGA1 TCF20 AHDC1 DNTTIP1

1.29e-06110327834189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PRR12 FLNA TNRC18 ZNF276 ABL1 NSD2 AHDC1 ARHGAP33

1.31e-06110527835748872
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

PRR12 TCF20 NSD2 AHDC1

1.52e-0610927433554859
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

PRR12 TNRC18 TCF20 AHDC1 DNTTIP1

1.84e-0626827533640491
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

PRR12 PRPF31 FLNA STAG1 SPINDOC

1.98e-0627227531010829
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

FLNA TNRC18 ABL1 NSD2 AHDC1

5.23e-0633227537433992
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PRPF31 FLNA HMGA1 TCF20 NSD2 HDGFL2 HP1BP3

6.28e-0695427736373674
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

HMGA1 ABL1 NSD2 AHDC1

6.47e-0615727430686591
Pubmed

Interaction network of human early embryonic transcription factors.

PRR12 TNRC18 TCF20 AHDC1 DNTTIP1

6.84e-0635127538297188
Pubmed

Structural and histone binding ability characterizations of human PWWP domains.

NSD2 HDGFL2

8.69e-06627221720545
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

FLNA TNRC18 HMGA1 STAG1 NSD2 HDGFL2 CDK5R2 HP1BP3

9.39e-06144227835575683
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PRPF31 HMGA1 TCF20 NSD2 AHDC1 ARHGAP33 HP1BP3

1.42e-05108227738697112
Pubmed

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

FLNA NSD2 HP1BP3

2.40e-057227331248990
Pubmed

USP13 interacts with cohesin and regulates its ubiquitination in human cells.

PRPF31 STAG1

3.81e-051227233334891
Pubmed

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

STAG1 HDGFL2 HP1BP3

7.21e-0510427326167872
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

PRPF31 HMGA1 TCF20 NSD2 HDGFL2 HP1BP3

1.06e-04101427632416067
Pubmed

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

NSD2 HDGFL2 AHDC1

1.22e-0412427320850016
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

PRPF31 TCF20 STAG1 HP1BP3

1.33e-0434127432971831
Pubmed

Identification of 14-3-3epsilon substrates from embryonic murine brain.

FLNA DLGAP3 ARHGAP33

1.46e-0413227316944949
Pubmed

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

PRR12 NSD2 ARHGAP33

1.85e-0414327332560809
Pubmed

RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.

STAG1 AHDC1 DNTTIP1

1.97e-0414627321589869
Pubmed

Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.

FLNA HMGA1 HP1BP3

2.53e-0415927334537242
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

PRR12 TCF20 HDGFL2 DNTTIP1

3.09e-0442527424999758
Pubmed

Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes.

PRPF31 FLNA

3.60e-043627231669268
Pubmed

Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.

PRPF31 FLNA SPINDOC

3.76e-0418227326527279
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

PRR12 KRBA1 HMGA1

3.88e-0418427332908313
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

PRR12 TCF20 STAG1 DNTTIP1

3.93e-0445327429656893
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

PRPF31 TCF20 STAG1 HDGFL2

4.59e-0447227438943005
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

HMGA1 NSD2 HP1BP3

4.60e-0419527319454010
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

PRPF31 HMGA1 STAG1 FOXL1 DNTTIP1

4.62e-0485727525609649
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

PRPF31 KRBA1 HDGFL2 HP1BP3

5.57e-0449727436774506
Pubmed

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.

HMGA1 DNTTIP1

6.14e-044727229617656
Pubmed

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.

FLNA HMGA1 HP1BP3

6.19e-0421627337640791
Pubmed

Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.

FLNA HMGA1

6.67e-044927219759913
InteractionCEBPA interactions

PRR12 PRPF31 FLNA TNRC18 HMGA1 TCF20 STAG1 HDGFL2 AHDC1 HP1BP3 DNTTIP1

1.56e-0712452611int:CEBPA
InteractionH2BC8 interactions

PRPF31 HMGA1 TCF20 STAG1 NSD2 HDGFL2 HP1BP3 DNTTIP1

4.21e-07576268int:H2BC8
InteractionH3C3 interactions

PRPF31 TCF20 STAG1 NSD2 HDGFL2 HP1BP3 DNTTIP1

2.27e-06495267int:H3C3
InteractionH3-3A interactions

PRPF31 HMGA1 TCF20 STAG1 NSD2 HDGFL2 HP1BP3 DNTTIP1

3.02e-06749268int:H3-3A
InteractionTLE3 interactions

PRR12 FLNA TNRC18 TCF20 AHDC1 FOXL1

6.80e-06376266int:TLE3
InteractionCENPA interactions

PRPF31 HMGA1 TCF20 NSD2 HDGFL2 HP1BP3

6.91e-06377266int:CENPA
InteractionCBX3 interactions

HMGA1 TCF20 NSD2 HDGFL2 AHDC1 ZNF689 HP1BP3

1.30e-05646267int:CBX3
InteractionDOK2 interactions

PRPF31 FLNA ABL1 SPINDOC

1.41e-05116264int:DOK2
InteractionH2BC21 interactions

PRR12 HMGA1 TCF20 NSD2 CDK5R2 HP1BP3 DNTTIP1

2.11e-05696267int:H2BC21
InteractionAR interactions

PRR12 FLNA TNRC18 ABL1 TCF20 NSD2 AHDC1 DNTTIP1

2.37e-05992268int:AR
InteractionNANOG interactions

HMGA1 TCF20 STAG1 NSD2 AHDC1 DNTTIP1

2.75e-05481266int:NANOG
InteractionCBX1 interactions

PRR12 HMGA1 HDGFL2 AHDC1 HP1BP3

2.96e-05288265int:CBX1
InteractionCDCA5 interactions

PRPF31 FLNA STAG1 SPINDOC

2.96e-05140264int:CDCA5
InteractionCHAMP1 interactions

HMGA1 NSD2 HDGFL2 AHDC1

3.68e-05148264int:CHAMP1
InteractionTOP3B interactions

PRR12 FLNA TNRC18 ZNF276 ABL1 NSD2 AHDC1 ARHGAP33 FOXL1

5.70e-051470269int:TOP3B
InteractionTWIST1 interactions

PRR12 TCF20 NSD2 AHDC1

6.32e-05170264int:TWIST1
InteractionEGR2 interactions

PRR12 TNRC18 AHDC1 DNTTIP1

6.47e-05171264int:EGR2
InteractionTLX1 interactions

PRR12 TCF20 HP1BP3 DNTTIP1

7.07e-05175264int:TLX1
InteractionHDAC2 interactions

FLNA HMGA1 TCF20 STAG1 NSD2 FOXL1 DNTTIP1

8.41e-05865267int:HDAC2
InteractionH3C1 interactions

TNRC18 HMGA1 STAG1 NSD2 HDGFL2 HP1BP3 DNTTIP1

1.09e-04901267int:H3C1
InteractionBRCA2 interactions

FLNA HMGA1 ABL1 NSD2 AHDC1

1.16e-04384265int:BRCA2
InteractionMEX3A interactions

FLNA TNRC18 ABL1 NSD2 AHDC1

1.16e-04384265int:MEX3A
InteractionNIPBL interactions

PRPF31 FLNA STAG1 SPINDOC

1.16e-04199264int:NIPBL
InteractionPHOSPHO2 interactions

FLNA DNTTIP1

1.24e-0413262int:PHOSPHO2
InteractionSNRNP40 interactions

PRPF31 FLNA TCF20 NSD2 HDGFL2 AHDC1

1.31e-04637266int:SNRNP40
InteractionSOX7 interactions

PRR12 TNRC18 TCF20

1.58e-0482263int:SOX7
InteractionMDC1 interactions

FLNA HMGA1 TCF20 NSD2 DNTTIP1

1.65e-04414265int:MDC1
InteractionHMGA1 interactions

TNRC18 HMGA1 TCF20 NSD2 HP1BP3

1.74e-04419265int:HMGA1
InteractionPARP1 interactions

PRPF31 HMGA1 ABL1 STAG1 NSD2 HDGFL2 HP1BP3 DNTTIP1

1.75e-041316268int:PARP1
InteractionSTAG2 interactions

PRR12 PRPF31 FLNA STAG1

1.83e-04224264int:STAG2
InteractionGSC interactions

PRR12 TNRC18 DNTTIP1

1.88e-0487263int:GSC
InteractionSMC5 interactions

PRPF31 FLNA HMGA1 TCF20 NSD2 HDGFL2 HP1BP3

2.08e-041000267int:SMC5
InteractionZNF330 interactions

PRPF31 HMGA1 TCF20 NSD2 HP1BP3

2.33e-04446265int:ZNF330
InteractionSOX17 interactions

PRR12 TCF20 DNTTIP1

2.44e-0495263int:SOX17
InteractionHMG20A interactions

HMGA1 TCF20 HP1BP3 FOXL1

2.54e-04244264int:HMG20A
InteractionPDS5A interactions

PRPF31 FLNA STAG1 FOXL1

2.58e-04245264int:PDS5A
InteractionCREB1 interactions

HMGA1 ABL1 BCAR3 NSD2

2.96e-04254264int:CREB1
InteractionCRX interactions

PRR12 TNRC18 TCF20 DNTTIP1

2.96e-04254264int:CRX
InteractionSTAG1 interactions

PRPF31 STAG1 FOXL1

3.18e-04104263int:STAG1
InteractionABL2 interactions

TNRC18 ABL1 BCAR3

3.46e-04107263int:ABL2
InteractionADARB1 interactions

FLNA TCF20 NSD2 ZNF689 HP1BP3

3.56e-04489265int:ADARB1
InteractionORC2 interactions

HMGA1 NSD2 FOXL1

3.75e-04110263int:ORC2
InteractionNSD2 interactions

FLNA HMGA1 NSD2 HP1BP3

4.17e-04278264int:NSD2
InteractionRBBP7 interactions

FLNA TNRC18 HMGA1 TCF20 STAG1

4.20e-04507265int:RBBP7
InteractionSTK17A interactions

PRPF31 HDGFL2

4.71e-0425262int:STK17A
InteractionRNF151 interactions

TNRC18 NSD2 ZNF689

5.21e-04123263int:RNF151
InteractionPRR11 interactions

NSD2 ZNF689 HP1BP3

6.12e-04130263int:PRR11
InteractionPAX9 interactions

PRR12 TCF20 DNTTIP1

6.12e-04130263int:PAX9
InteractionMAU2 interactions

PRR12 PRPF31 FLNA

6.98e-04136263int:MAU2
InteractionH2BC12 interactions

TNRC18 HMGA1 CDK5R2 HP1BP3

7.24e-04322264int:H2BC12
InteractionRBBP4 interactions

FLNA TNRC18 HMGA1 TCF20 STAG1

7.32e-04573265int:RBBP4
InteractionLLPH interactions

NSD2 ZNF689 HP1BP3

7.43e-04139263int:LLPH
InteractionSOX15 interactions

PRR12 HP1BP3 DNTTIP1

7.75e-04141263int:SOX15
InteractionPPIA interactions

PRPF31 ABL1 TCF20 STAG1 NSD2 HDGFL2

7.76e-04888266int:PPIA
InteractionTLX2 interactions

PRR12 TCF20 DNTTIP1

7.91e-04142263int:TLX2
InteractionNFIB interactions

PRR12 FOXL1 DNTTIP1

7.91e-04142263int:NFIB
InteractionZBTB47 interactions

NSD2 ZNF689 HP1BP3

8.23e-04144263int:ZBTB47
InteractionYWHAE interactions

PRPF31 FLNA DLGAP3 HMGA1 ABL1 SPINDOC ARHGAP33

8.27e-041256267int:YWHAE
InteractionEWSR1 interactions

PRR12 HMGA1 ABL1 TCF20 HDGFL2 DNTTIP1

8.62e-04906266int:EWSR1
InteractionITGB7 interactions

FLNA HMGA1

8.75e-0434262int:ITGB7
InteractionMECP2 interactions

PRPF31 HMGA1 TCF20 NSD2 AHDC1 ARHGAP33 HP1BP3

9.56e-041287267int:MECP2
InteractionXRCC6 interactions

TNRC18 HMGA1 ABL1 TCF20 NSD2 HDGFL2

9.77e-04928266int:XRCC6
InteractionCHD4 interactions

PRPF31 HMGA1 TCF20 NSD2 HDGFL2 HP1BP3

1.03e-03938266int:CHD4
InteractionBAZ1A interactions

HMGA1 STAG1 FOXL1

1.04e-03156263int:BAZ1A
InteractionNUP43 interactions

FLNA TCF20 NSD2 AHDC1 HP1BP3

1.08e-03625265int:NUP43
InteractionDDA1 interactions

HMGA1 TCF20 STAG1 AHDC1

1.19e-03368264int:DDA1
InteractionCRK interactions

FLNA ABL1 BCAR3 ARHGAP33

1.21e-03370264int:CRK
InteractionTP73 interactions

FLNA ABL1 STAG1

1.31e-03169263int:TP73
InteractionASB2 interactions

FLNA SPINDOC

1.33e-0342262int:ASB2
InteractionCPM interactions

FLNA AHDC1

1.33e-0342262int:CPM
InteractionMYCN interactions

FLNA HMGA1 TCF20 STAG1 HDGFL2 HP1BP3 DNTTIP1

1.40e-031373267int:MYCN
InteractionWAPL interactions

PRPF31 FLNA STAG1

1.40e-03173263int:WAPL
InteractionLSM4 interactions

PRPF31 HMGA1 HP1BP3

1.52e-03178263int:LSM4
InteractionPDS5B interactions

PRPF31 STAG1 SPINDOC

1.52e-03178263int:PDS5B
InteractionH2BC18 interactions

PRPF31 HMGA1 CDK5R2

1.57e-03180263int:H2BC18
Cytoband2q35

CDK5R2 TMEM198

9.98e-04792722q35
CytobandEnsembl 112 genes in cytogenetic band chr2q35

CDK5R2 TMEM198

2.63e-03129272chr2q35
CytobandEnsembl 112 genes in cytogenetic band chr16q24

ZNF276 FOXL1

2.91e-03136272chr16q24
GeneFamilySH2 domain containing

ABL1 BCAR3

1.64e-03101112741
DiseaseNeurodevelopmental delay

NSD2 KCNK4

1.69e-057272C4022738
DiseaseIntellectual Disability

PRR12 TCF20 STAG1 NSD2 KCNK4

4.78e-05447275C3714756
DiseaseL2 Acute Lymphoblastic Leukemia

ABL1 NSD2

9.61e-0450272C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

ABL1 NSD2

1.04e-0352272C0023452
DiseaseMammary Neoplasms, Human

FLNA ABL1 BCAR3 NSD2

1.26e-03525274C1257931
DiseaseMammary Carcinoma, Human

FLNA ABL1 BCAR3 NSD2

1.26e-03525274C4704874
DiseaseMammary Neoplasms

FLNA ABL1 BCAR3 NSD2

1.27e-03527274C1458155
DiseaseBreast Carcinoma

FLNA ABL1 BCAR3 NSD2

1.37e-03538274C0678222
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

ABL1 NSD2

1.43e-0361272C1961102
Diseasedentures

STAG1 FOXL1

1.87e-0370272EFO_0010078
Diseasedental caries, dentures

STAG1 FOXL1

1.87e-0370272EFO_0003819, EFO_0010078
DiseaseAlzheimer disease, polygenic risk score

TCF20 ZNF689 HP1BP3 ME3

1.88e-03586274EFO_0030082, MONDO_0004975

Protein segments in the cluster

PeptideGeneStartEntry
LPRKKKGPPPIRSCD

BCAR3

51

O75815
KRGRPPKNLLLGPGK

AHDC1

546

Q5TGY3
RRPGGLPEEKKKAPP

CDK5R2

16

Q13319
AQRGKARPLPKKAPP

HP1BP3

486

Q5SSJ5
RQKGPTRPKPKILRG

KRBA1

876

A5PL33
KPVRPRGPGRPRDKG

KCNK4

376

Q9NYG8
GLPVKKPRLRGPRPG

ISM2

26

Q6H9L7
PPPEPGKPKGKRRRR

NSD2

1341

O96028
GRKPAEKPLPKPRGR

HDGFL2

276

Q7Z4V5
LCKPGKPERKFAPPR

MCIDAS

31

D6RGH6
KPGKRLSAPRGPFPR

ARHGAP33

31

O14559
PGAPLRPKLNPKKAR

FLNA

271

P21333
KVPPPIPKKPLRGRG

DLGAP3

911

O95886
GRDKGKLSRLKPAPP

ABL1

886

P00519
SKPGPARPVPLKKRG

ME3

36

Q16798
RKRKPKPGPGAPEAK

FOXL1

141

Q12952
VPTPKRPRGRPKGSK

HMGA1

51

P17096
EPPGEEPVRKKRGRP

SPINDOC

221

Q9BUA3
GRKPTKAKRDGPPRP

PRR12

1156

Q9ULL5
PPPLFGKKDPRARGE

TNRC18

216

O15417
SPLPKKRKGRPPGHI

DNTTIP1

161

Q9H147
KPLPAPLDGQRKKRG

PRPF31

341

Q8WWY3
EPRIRKKPGPKPGWK

ZNF276

406

Q8N554
KRGRPGRPPSTNKKP

STAG1

36

Q8WVM7
PAKTKILPPRKGRGL

TCF20

1336

Q9UGU0
PPKEAPRKGKRGRRP

ZNF689

121

Q96CS4
KRRKKRPPRAPLRGP

TMEM198

271

Q66K66