Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	myosin binding	TRIM32 STXBP5L ARFGEF2 ARFGEF1 TRIOBP	9.04e-06	85	66	5	GO:0017022
GeneOntologyCellularComponent	keratin filament	KRTAP9-6 KRTAP12-2 KRTAP11-1 KRTAP16-1 KRT80	1.39e-05	97	66	5	GO:0045095
MousePheno	absent enteric neurons	RET ECE1 GFRA1	3.15e-06	9	48	3	MP:0001048
MousePheno	abnormal pterygopalatine ganglion morphology	RET GFRA1	3.46e-05	3	48	2	MP:0008314
MousePheno	abnormal enteric neuron morphology	RET ECE1 GFRA1	5.59e-05	22	48	3	MP:0001046
MousePheno	absent foregut	GATA4 SMAD2	1.15e-04	5	48	2	MP:0012083
MousePheno	abnormal enteric nervous system morphology	RET ECE1 GFRA1	1.60e-04	31	48	3	MP:0001044
Domain	LU	LY6D SLURP1 LYPD2	2.28e-05	16	66	3	SM00134
Domain	UPAR_LY6	LY6D SLURP1 LYPD2	4.60e-05	20	66	3	PF00021
Domain	LY6_UPAR	LY6D SLURP1 LYPD2	6.19e-05	22	66	3	PS00983
Domain	LY6_UPA_recep-like	LY6D SLURP1 LYPD2	6.19e-05	22	66	3	IPR016054
Domain	DUF1981	ARFGEF2 ARFGEF1	7.35e-05	4	66	2	PF09324
Domain	Sec7_N	ARFGEF2 ARFGEF1	7.35e-05	4	66	2	IPR032691
Domain	Sec7_N	ARFGEF2 ARFGEF1	7.35e-05	4	66	2	PF12783
Domain	DCB_dom	ARFGEF2 ARFGEF1	7.35e-05	4	66	2	IPR032629
Domain	DCB	ARFGEF2 ARFGEF1	7.35e-05	4	66	2	PF16213
Domain	Sec7_C	ARFGEF2 ARFGEF1	7.35e-05	4	66	2	IPR015403
Domain	DEATH	IRAK3 TNFRSF21 UNC5D	1.16e-04	27	66	3	SM00005
Domain	CD59_antigen_CS	LY6D LYPD2	1.83e-04	6	66	2	IPR018363
Domain	Death	IRAK3 TNFRSF21 UNC5D	2.13e-04	33	66	3	PF00531
Domain	Death_domain	IRAK3 TNFRSF21 UNC5D	3.25e-04	38	66	3	IPR000488
Domain	DEATH_DOMAIN	IRAK3 TNFRSF21 UNC5D	3.25e-04	38	66	3	PS50017
Domain	PMG	KRTAP12-2 KRTAP11-1	9.36e-04	13	66	2	PF05287
Domain	KRTAP_PMG	KRTAP12-2 KRTAP11-1	9.36e-04	13	66	2	IPR007951
Domain	KAP	KRTAP9-6 KRTAP12-2 KRTAP16-1	1.13e-03	58	66	3	IPR002494
Domain	-	ARFGEF2 ARFGEF1	1.25e-03	15	66	2	1.10.1000.11
Domain	Sec7	ARFGEF2 ARFGEF1	1.25e-03	15	66	2	PF01369
Domain	Sec7_alpha_orthog	ARFGEF2 ARFGEF1	1.25e-03	15	66	2	IPR023394
Domain	Sec7	ARFGEF2 ARFGEF1	1.43e-03	16	66	2	SM00222
Domain	SEC7	ARFGEF2 ARFGEF1	1.43e-03	16	66	2	PS50190
Domain	Sec7_dom	ARFGEF2 ARFGEF1	1.43e-03	16	66	2	IPR000904
Domain	VWC_out	JAG1 MUC5AC	2.02e-03	19	66	2	SM00215
Domain	-	IRAK3 TNFRSF21 UNC5D	4.36e-03	93	66	3	1.10.533.10
Domain	DEATH-like_dom	IRAK3 TNFRSF21 UNC5D	5.19e-03	99	66	3	IPR011029
Domain	ASX_HYDROXYL	JAG1 DLK1 ADGRE2	5.34e-03	100	66	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	JAG1 DLK1 ADGRE2	6.27e-03	106	66	3	IPR000152
Domain	GPS	ADGRF3 ADGRE2	6.41e-03	34	66	2	SM00303
Domain	GPCR_2_secretin-like_CS	ADGRF3 ADGRE2	6.41e-03	34	66	2	IPR017983
Domain	GPS	ADGRF3 ADGRE2	6.79e-03	35	66	2	PF01825
Domain	GPS	ADGRF3 ADGRE2	7.17e-03	36	66	2	PS50221
Domain	Cadherin	CDH24 PCDHA7 RET	7.48e-03	113	66	3	PF00028
Domain	GPS	ADGRF3 ADGRE2	7.56e-03	37	66	2	IPR000203
Domain	CADHERIN_2	CDH24 PCDHA7 RET	7.67e-03	114	66	3	PS50268
Domain	-	CDH24 PCDHA7 RET	7.67e-03	114	66	3	2.60.40.60
Domain	CA	CDH24 PCDHA7 RET	7.85e-03	115	66	3	SM00112
Domain	VWC	JAG1 MUC5AC	7.97e-03	38	66	2	SM00214
Domain	Cadherin-like	CDH24 PCDHA7 RET	8.04e-03	116	66	3	IPR015919
Domain	Keratin_B2_2	KRTAP9-6 KRTAP16-1	8.38e-03	39	66	2	PF13885
Domain	Cadherin	CDH24 PCDHA7 RET	8.43e-03	118	66	3	IPR002126
Domain	EGF_CA	JAG1 DLK1 ADGRE2	9.23e-03	122	66	3	SM00179
Domain	Kinesin_motor_CS	STARD9 KIF24	9.23e-03	41	66	2	IPR019821
Domain	EGF	JAG1 LAMC1 DLK1 ADGRE2	9.58e-03	235	66	4	SM00181
Domain	EGF-like_Ca-bd_dom	JAG1 DLK1 ADGRE2	9.64e-03	124	66	3	IPR001881
Domain	VWF_dom	JAG1 MUC5AC	9.67e-03	42	66	2	IPR001007
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	FLI1 KRTAP9-6 KRTAP12-2 JAG1 POLR2B GATA4 LAMC1 RET KRTAP11-1 KRTAP16-1 UNC5D GFRA1 SMAD2 KRT80 PML HSP90AB1	2.04e-05	1432	50	16	M509
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	KRTAP9-6 KRTAP12-2 RET KRTAP11-1 KRTAP16-1 GFRA1 SMAD2 KRT80 HSP90AB1	5.84e-05	502	50	9	MM14537
Pathway	REACTOME_KERATINIZATION	KRTAP9-6 KRTAP12-2 KRTAP11-1 KRTAP16-1 KRT80	2.02e-04	153	50	5	MM15343
Pubmed	Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching.	JAG1 RET GFRA1	8.12e-07	10	67	3	15905075
Pubmed	Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.	RET ECE1 GFRA1	2.45e-06	14	67	3	27370713
Pubmed	Expression of GDNF receptors GFRalpha1 and RET is preserved in substantia nigra pars compacta of aging Asian Indians.	RET GFRA1	3.66e-06	2	67	2	20347960
Pubmed	Jagged-1: a new promising factor associated with favorable prognosis in patients with acute myeloid leukemia.	JAG1 DLK1	3.66e-06	2	67	2	24844362
Pubmed	Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs.	RET GFRA1	3.66e-06	2	67	2	9262196
Pubmed	Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.	ARFGEF2 ARFGEF1	3.66e-06	2	67	2	23918382
Pubmed	[RET and GFRA1 germline polymorphisms in medullary thyroid cancer patients].	RET GFRA1	3.66e-06	2	67	2	16813162
Pubmed	Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.	ARFGEF2 ARFGEF1	3.66e-06	2	67	2	17360629
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	3.66e-06	2	67	2	10716990
Pubmed	Association Between RET (rs1800860) and GFRA1 (rs45568534, rs8192663, rs181595401, rs7090693, and rs2694770) Variants and Kidney Size in Healthy Newborns.	RET GFRA1	3.66e-06	2	67	2	27533506
Pubmed	Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.	ARFGEF2 ARFGEF1	3.66e-06	2	67	2	18203920
Pubmed	The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis.	RET GFRA1	3.66e-06	2	67	2	15621530
Pubmed	Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	3.66e-06	2	67	2	10212200
Pubmed	Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations.	RET GFRA1	3.66e-06	2	67	2	22729463
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	3.66e-06	2	67	2	18417613
Pubmed	Enhancer Variants Synergistically Drive Dysfunction of a Gene Regulatory Network In Hirschsprung Disease.	GATA4 RET GFRA1	3.76e-06	16	67	3	27693352
Pubmed	GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival.	RET GFRA1	1.10e-05	3	67	2	10774729
Pubmed	Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	19332778
Pubmed	Specific functions of BIG1 and BIG2 in endomembrane organization.	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	20360857
Pubmed	GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.	RET GFRA1	1.10e-05	3	67	2	8674117
Pubmed	Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling.	RET GFRA1	1.10e-05	3	67	2	18394855
Pubmed	AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	16866877
Pubmed	Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors.	RET GFRA1	1.10e-05	3	67	2	11932334
Pubmed	Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells.	RET GFRA1	1.10e-05	3	67	2	15589513
Pubmed	Tissue expression of alternatively spliced GFRalpha1, NCAM and RET isoforms and the distinct functional consequence of ligand-induced activation of GFRalpha1 isoforms.	RET GFRA1	1.10e-05	3	67	2	15979200
Pubmed	GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.	RET GFRA1	1.10e-05	3	67	2	24778213
Pubmed	Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate.	RET GFRA1	1.10e-05	3	67	2	16237148
Pubmed	ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model.	RET GFRA1	1.10e-05	3	67	2	36758123
Pubmed	Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling.	RET GFRA1	1.10e-05	3	67	2	16551639
Pubmed	The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding.	RET GFRA1	1.10e-05	3	67	2	18845535
Pubmed	A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	18832381
Pubmed	Hirschsprung disease and congenital anomalies of the kidney and urinary tract (CAKUT): a novel syndromic association.	RET GFRA1	1.10e-05	3	67	2	19282698
Pubmed	Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age.	RET GFRA1	1.10e-05	3	67	2	17825269
Pubmed	Glia cell line-derived neurotrophic factor regulates the distribution of acetylcholine receptors in mouse primary skeletal muscle cells.	RET GFRA1	1.10e-05	3	67	2	15381279
Pubmed	Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	31199673
Pubmed	Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	18003980
Pubmed	Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	27162341
Pubmed	GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion.	RET GFRA1	1.10e-05	3	67	2	17310246
Pubmed	Lipid Rafts Are Physiologic Membrane Microdomains Necessary for the Morphogenic and Developmental Functions of Glial Cell Line-Derived Neurotrophic Factor In Vivo.	RET GFRA1	1.10e-05	3	67	2	26400951
Pubmed	The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).	ARFGEF2 ARFGEF1	1.10e-05	3	67	2	23386609
Pubmed	Site-specific gene expression and localization of growth factor ligand receptors RET, GFRα1 and GFRα2 in human adult colon.	RET GFRA1	1.10e-05	3	67	2	23881409
Pubmed	Neural crest cell-autonomous roles of fibronectin in cardiovascular development.	JAG1 LAMC1 SMAD2	1.34e-05	24	67	3	26552887
Pubmed	Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis.	RET ECE1 GFRA1	1.34e-05	24	67	3	17131407
Pubmed	Development of heart valves requires Gata4 expression in endothelial-derived cells.	GATA4 ALB	2.19e-05	4	67	2	16914500
Pubmed	GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells.	RET GFRA1	2.19e-05	4	67	2	9749804
Pubmed	Immunohistological analysis of neurturin and its receptors in human cochlea.	RET GFRA1	2.19e-05	4	67	2	24139947
Pubmed	Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development.	RET GFRA1	2.19e-05	4	67	2	10068631
Pubmed	A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor.	RET GFRA1	2.19e-05	4	67	2	9192898
Pubmed	Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.	RET GFRA1	2.19e-05	4	67	2	19710321
Pubmed	Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.	ARFGEF2 ARFGEF1	2.19e-05	4	67	2	11013081
Pubmed	GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells.	RET GFRA1	2.19e-05	4	67	2	32566252
Pubmed	Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.	ARFGEF2 ARFGEF1	2.19e-05	4	67	2	12606707
Pubmed	Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family.	RET GFRA1	2.19e-05	4	67	2	9452475
Pubmed	SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.	RET GFRA1	2.19e-05	4	67	2	23333276
Pubmed	Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis.	RET GFRA1	2.19e-05	4	67	2	9415430
Pubmed	Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).	ARFGEF2 ARFGEF1	2.19e-05	4	67	2	12571360
Pubmed	Possible involvement of glial cell line-derived neurotrophic factor and its receptor, GFRalpha1, in survival and maturation of thymocytes.	RET GFRA1	2.19e-05	4	67	2	12884298
Pubmed	Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.	RET GFRA1	2.19e-05	4	67	2	22902718
Pubmed	Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.	ARFGEF2 ARFGEF1	2.19e-05	4	67	2	22084092
Pubmed	GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin.	RET GFRA1	2.19e-05	4	67	2	9740802
Pubmed	Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis.	RET PML	2.19e-05	4	67	2	14522971
Pubmed	Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene.	RET GFRA1	2.19e-05	4	67	2	11731455
Pubmed	Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system.	RET GFRA1	2.19e-05	4	67	2	23994200
Pubmed	Glial cell line-derived neurotrophic factor induces cell proliferation in the mouse urogenital sinus.	RET GFRA1	2.19e-05	4	67	2	25549043
Pubmed	Notch signaling in stomach epithelial stem cell homeostasis.	JAG1 DLK1 MUC5AC	2.41e-05	29	67	3	21402740
Pubmed	Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.	RET MUC5AC GFRA1	2.67e-05	30	67	3	17882221
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	JAG1 SLURP1 IRAK3 LTA4H PGLYRP3 GIMAP7 ADGRE2 TNFRSF21 KLRG1	2.82e-05	824	67	9	20237496
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	CDH24 DLK1 RET GFRA1	2.96e-05	91	67	4	28558017
Pubmed	A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.	FLI1 GATA4 PML	3.26e-05	32	67	3	23049088
Pubmed	RET/GFRα signals are dispensable for thymic T cell development in vivo.	RET GFRA1	3.64e-05	5	67	2	23300832
Pubmed	Gfra1 Underexpression Causes Hirschsprung's Disease and Associated Enterocolitis in Mice.	RET GFRA1	3.64e-05	5	67	2	30594740
Pubmed	Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse.	RET GFRA1	3.64e-05	5	67	2	10415156
Pubmed	Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions.	RET GFRA1	3.64e-05	5	67	2	10829012
Pubmed	Molecular analysis of congenital central hypoventilation syndrome.	RET GFRA1	3.64e-05	5	67	2	14566559
Pubmed	Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret.	RET GFRA1	3.64e-05	5	67	2	12195422
Pubmed	TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.	RET GFRA1	3.64e-05	5	67	2	9182803
Pubmed	Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs.	RET GFRA1	3.64e-05	5	67	2	9334423
Pubmed	Interaction with the Bardet-Biedl gene product TRIM32/BBS11 modifies the half-life and localization of Glis2/NPHP7.	TRIM32 PML	3.64e-05	5	67	2	24500717
Pubmed	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.	FLI1 SMAD2 PML	4.28e-05	35	67	3	22325351
Pubmed	Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression.	GATA4 GFRA1	5.46e-05	6	67	2	30988352
Pubmed	A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development.	RET GFRA1	5.46e-05	6	67	2	10712625
Pubmed	The complex interplay between ERK1/2, TGFβ/Smad, and Jagged/Notch signaling pathways in the regulation of epithelial-mesenchymal transition in retinal pigment epithelium cells.	JAG1 SMAD2	5.46e-05	6	67	2	24788939
Pubmed	Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes.	RET GFRA1	5.46e-05	6	67	2	10864958
Pubmed	Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.	JAG1 DLK1	5.46e-05	6	67	2	10958687
Pubmed	IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life.	RET GFRA1	5.46e-05	6	67	2	9354331
Pubmed	Development gone awry: congenital heart disease.	GATA4 ECE1	5.46e-05	6	67	2	14976138
Pubmed	Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development.	RET GFRA1	5.46e-05	6	67	2	10860579
Pubmed	GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRalpha2.	RET GFRA1	5.46e-05	6	67	2	10974669
Pubmed	Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation.	RET GFRA1	5.46e-05	6	67	2	9786421
Pubmed	Cytoplasmic PML function in TGF-beta signalling.	SMAD2 PML	5.46e-05	6	67	2	15356634
Pubmed	Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.	LY6D SLURP1 LYPD2	5.49e-05	38	67	3	27098205
Pubmed	Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins.	RET GFRA1	7.63e-05	7	67	2	11003834
Pubmed	Mesenchymal cells regulate enteric neural crest cell migration via RET-GFRA1b trans-signaling.	RET GFRA1	7.63e-05	7	67	2	38581949
Pubmed	GFRalpha 1 is required for development of distinct subpopulations of motoneuron.	RET GFRA1	7.63e-05	7	67	2	10864957
Pubmed	Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.	RET GFRA1	7.63e-05	7	67	2	17322904
Pubmed	MafA transcription factor identifies the early ret-expressing sensory neurons.	RET KLRG1	7.63e-05	7	67	2	20213756
Pubmed	The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction.	RET GFRA1	7.63e-05	7	67	2	15204970
Pubmed	GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.	GATA4 MUC5AC	7.63e-05	7	67	2	22554936
Pubmed	Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice.	RET GFRA1	7.63e-05	7	67	2	16497798
Pubmed	Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.	SMAD2 PML	7.63e-05	7	67	2	16916642
Cytoband	19q13.41	ZNF28 CLDND2 ZNF468	2.09e-04	78	67	3	19q13.41
GeneFamily	CD molecules\|Complement system\|LY6/PLAUR domain containing	LY6D SLURP1 LYPD2	1.33e-04	34	53	3	1226
GeneFamily	Keratin associated proteins	KRTAP9-6 KRTAP12-2 KRTAP11-1 KRTAP16-1	2.92e-04	109	53	4	619
CoexpressionAtlas	NK cells, NK.MCMV7.Sp, CD3-,NK1.1+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	5.48e-05	72	61	4	GSM538312_100
CoexpressionAtlas	NK cells, NK.MCMV1.Sp, CD3-,NK1.1+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	5.78e-05	73	61	4	GSM538309_100
CoexpressionAtlas	NK cells, NK.H+.MCMV7.Sp, NK1.1+ TCRb- Ly49H+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	6.43e-05	75	61	4	GSM538303_100
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d8.LisOva, CD8+ CD45.1+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	7.13e-05	77	61	4	GSM605901_100
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d15.LisOva, CD8+ CD45.1+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	7.13e-05	77	61	4	GSM605894_100
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d10.LisOva, CD8+ CD45.1+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	7.50e-05	78	61	4	GSM605891_100
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d6.VSVOva, CD8+ CD45.1+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	7.88e-05	79	61	4	GSM538389_100
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3	OSBPL3 CLDND2 GIMAP7 KLRG1	8.28e-05	80	61	4	GSM605898_100
ToppCell	facs-GAT-Fat-3m-Lymphocytic-NK_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OSBPL3 CLDND2 LTA4H ADGRE2 KLRG1	3.25e-06	151	67	5	3d07b79ecbcfad13116f0f2b039bd181a7ffe853
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLURP1 LYPD2 MUC5AC UNC5D KRT80	6.68e-06	175	67	5	8252ddc2ca95071381f0354aefb70c4714828491
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLURP1 LYPD2 MUC5AC UNC5D KRT80	6.68e-06	175	67	5	8ccf60fc469059d7aaf4e6ce54159db2962e0060
ToppCell	Nasal_Brush\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	LY6D SLURP1 LYPD2 IRAK3 MUC5AC	1.13e-05	195	67	5	7509b980b6b293df02bec619ef5b83a6c7b49c03
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	LYPD2 IRAK3 ADGRE2 ECE1 TNFRSF21	1.13e-05	195	67	5	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	Goblet_1\|World / shred by cell class for nasal brushing	LY6D SLURP1 LYPD2 IRAK3 MUC5AC	1.13e-05	195	67	5	d9e4889a2e7b7c97c07c15b043b77837739462e4
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Mgp-Endothelial_Tip.Dcn.Mgp-Clu_(Clu)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLURP1 LYPD2 PGLYRP3 KRT80	1.35e-05	96	67	4	9a1da3809073a4321134bf3767e0a40398b69caa
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ADGRF3 KRTAP16-1 KLRG1 GFRA1	4.99e-05	134	67	4	72d7eec3aeb43319f3ef81bb5518fae8d8880136
ToppCell	LPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSPAN19 PGLYRP3 GIMAP7 UNC5D	5.75e-05	139	67	4	ecc2a6ecc27748c50885cd4f0ad8a8cd1252aee6
ToppCell	NS-control-d_0-4-Epithelial-Secretory-diff\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LY6D LYPD2 MUC5AC	6.25e-05	51	67	3	a6f623dba72ce85683e692a68095926e4e71b765
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Cadm1_(Cerebellum_basket_cells_3)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CDH24 SLURP1 XKR5	6.25e-05	51	67	3	0611419cc63dbe772d10c1f6f96826786351f048
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Cadm1_(Cerebellum_basket_cells_3)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CDH24 SLURP1 XKR5	6.25e-05	51	67	3	a673b6d6ddecb7c239cb49ff490188460edc87e0
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	KRTAP9-6 KRTAP12-2 KRTAP11-1 KRTAP16-1	6.96e-05	146	67	4	522c32103c24fc26836bb5b642083904682d9292
ToppCell	facs-Lung-3m-Hematologic-Lymphocytic_NK_ILC\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OSBPL3 CLDND2 GIMAP7 KLRG1	7.73e-05	150	67	4	1f83e3be3f94aefe991a3ccd292c2d11ddef858e
ToppCell	facs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OSBPL3 CLDND2 GIMAP7 KLRG1	7.73e-05	150	67	4	cd666db614bc1b43d71e8eb7bf38cae4d580be80
ToppCell	facs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OSBPL3 CLDND2 GIMAP7 KLRG1	7.73e-05	150	67	4	f6ed3e7b36014d1e429b255b0027d89865e1ac07
ToppCell	Control-Epithelial_airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OSBPL3 TSPAN19 ALB KRT80	9.45e-05	158	67	4	35aee1c3b92169e73569331022833cb44ab7e7e8
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OSBPL3 CLDND2 RET KLRG1	9.68e-05	159	67	4	d2de9391b00b6c47f5fe28a1bad6da2097107ee0
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OSBPL3 CLDND2 RET KLRG1	9.68e-05	159	67	4	da6b7f8039adc19839d6c090a0b3d68fb6445a79
ToppCell	LPS-IL1RA-Epithelial_airway\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OSBPL3 TSPAN19 ALB KRT80	1.02e-04	161	67	4	472c354f5ee148b37a5dfb795e83348ecb1643f1
ToppCell	Influenza_Severe-gd_T\|World / Disease group and Cell class	STARD9 OTUD7A KRTAP16-1 KLRG1	1.02e-04	161	67	4	b3cdaed4d58d57e3c5dbc904a09388f3bf949407
ToppCell	facs-BAT-Fat-18m-Lymphocytic-NK_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OSBPL3 LTA4H GIMAP7 KLRG1	1.09e-04	164	67	4	ab9c17f86b98e1a4d5db1bd3086edab1320ebda8
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STXBP5L DGKB RET UNC5D	1.09e-04	164	67	4	be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OSBPL3 GIMAP7 KLRG1 UNC5D	1.12e-04	165	67	4	d91fabc5b26c27577eea27be8a305fec5c004164
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D CLDND2 GIMAP7 KLRG1	1.14e-04	166	67	4	b7027802cac6ebf3c4a19ef11c9164d92694a4eb
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D FLI1 TOP3A PML	1.14e-04	166	67	4	6a948aefd283a2572da37b59dbc142b6e686b024
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D FLI1 TOP3A PML	1.14e-04	166	67	4	8d0c4eb90a2c006f96ae61d3d94c96fb64bc0c4d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D CLDND2 GIMAP7 KLRG1	1.14e-04	166	67	4	dbb73742db00982539b1800aef8af2801b3a0598
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	1.17e-04	167	67	4	805129f887078340b260aa136b0ba19f2bd6ea03
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	1.17e-04	167	67	4	31cf8bf2eb523f6e7e319620648ff37fc09e2601
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	1.17e-04	167	67	4	3acb18428d1d33ad430c2fd031b1a91baee3c01d
ToppCell	Influenza_Severe-gd_T\|Influenza_Severe / Disease group and Cell class	STARD9 OTUD7A KRTAP16-1 KLRG1	1.25e-04	170	67	4	59009c5a504ea8c6b4f6697299db219fd5edf7d6
ToppCell	Monocytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	FLI1 LYPD2 GIMAP7 ADGRE2	1.25e-04	170	67	4	4e93b66b3033e6e4d5f6d2f41974623a53108f5e
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OSBPL3 RET GIMAP7 KLRG1	1.25e-04	170	67	4	bcbe5c44ef708c5f01dc7dd9aec7b436e1a62d56
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OSBPL3 SLURP1 KLRG1 XKR5	1.28e-04	171	67	4	1eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Th_Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CLDND2 SLURP1 KLRG1	1.29e-04	65	67	3	c336aa3501b9576bf12ef1bbefae55fff7705662
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	OSBPL3 GATA4 DLK1 UNC5D	1.34e-04	173	67	4	b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	CCDC14 ZNF468 ADGRE2 ANKHD1	1.43e-04	176	67	4	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	facs-GAT-Fat-3m-Lymphocytic\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D FLI1 ADGRE2 KLRG1	1.43e-04	176	67	4	2e3f25a338842384517656d05776a52cbfc62b52
ToppCell	facs-GAT-Fat-3m-Lymphocytic-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D FLI1 ADGRE2 KLRG1	1.43e-04	176	67	4	0823088bc6b19c7ad784d83c2ccdfae80611afab
ToppCell	wk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CDH24 DGKB RET GFRA1	1.46e-04	177	67	4	15a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STARD9 IRAK3 GIMAP7 ECE1	1.49e-04	178	67	4	375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCell	Club_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	LY6D SLURP1 TNFRSF21 MUC5AC	1.49e-04	178	67	4	be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCell	control-Epithelial-Secretory-diff\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LY6D LYPD2 MUC5AC	1.54e-04	69	67	3	2c1eb6b358c323b4b6a642f473068681987a9e91
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STXBP5L DLK1 KRTAP16-1 KRT80	1.56e-04	180	67	4	0c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCell	Monocytes-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	FLI1 IRAK3 GIMAP7 ADGRE2	1.59e-04	181	67	4	d8b98c3d9bef026a0a35948219027f27718ffbee
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	STXBP5L DGKB RET UNC5D	1.63e-04	182	67	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LY6D GATA4 STYXL2 GFRA1	1.66e-04	183	67	4	9a2cd63af5f492d46ce80ca1536312e8ac0e7df4
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4\|TCGA-Uvea / Sample_Type by Project: Shred V9	FLI1 OSBPL3 ARFGEF1 GIMAP7	1.70e-04	184	67	4	9c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STXBP5L DGKB DLK1 RET	1.70e-04	184	67	4	d5e44c9085da2a46531ed6db1249bdd88c41b45c
ToppCell	facs-Marrow-T-cells-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D ALB GIMAP7 ADGRE2	1.73e-04	185	67	4	e1fd0a807def8c2127194108b1a30c6de7024292
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DGKB IRAK3 KIF24 UNC5D	1.77e-04	186	67	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	STXBP5L DGKB RET UNC5D	1.77e-04	186	67	4	fcabebdfbf1b1dbb35ce2b3c53a60d2b1aed8e6c
ToppCell	control-Epithelial-Secretory-diff\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LY6D LYPD2 MUC5AC	1.82e-04	73	67	3	dded04580ac197d3471a8ed43e1e61c56ee09f78
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRIOBP LAMC1 IRAK3 RET	1.84e-04	188	67	4	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLURP1 LYPD2 TNFRSF21 GFRA1	1.88e-04	189	67	4	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLURP1 LYPD2 TNFRSF21 GFRA1	1.88e-04	189	67	4	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLI1 JAG1 ADGRE2 ECE1	1.88e-04	189	67	4	1e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LYPD2 IRAK3 ADGRE2 ECE1	1.92e-04	190	67	4	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JAG1 OTUD7A ADGRE2 ECE1	1.92e-04	190	67	4	eae5bcdb8a35f3fba4d25854c1a43f83f80832a2
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	LY6D SLURP1 PGLYRP3 KRT80	1.92e-04	190	67	4	3188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCell	TCGA-Skin-Primary_Tumor\|TCGA-Skin / Sample_Type by Project: Shred V9	LY6D SLURP1 PGLYRP3 KRT80	1.92e-04	190	67	4	e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	LY6D SLURP1 PGLYRP3 KRT80	1.92e-04	190	67	4	01fb45add4661bc86cd0a34fac35177907152dbb
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JAG1 OTUD7A ADGRE2 ECE1	1.92e-04	190	67	4	3346bfd0474828b3729cffa9f4cc57b04dd30443
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	1.96e-04	191	67	4	cd709bbcd320373468ea7f058ee5fda8a067b5d0
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	1.96e-04	191	67	4	14851529025cfc2b665f71ebad04150ec543da7a
ToppCell	Monocytes-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	LYPD2 IRAK3 GIMAP7 ADGRE2	1.96e-04	191	67	4	ca0a5dc82cdef02e88fed937ca5784761896af33
ToppCell	NS-critical-d_0-4\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LY6D LYPD2 SLC30A1 MUC5AC	1.96e-04	191	67	4	769942a6a31c13c583dc38e8a762df2f5c06c2fb
ToppCell	IPF-Epithelial-Goblet\|Epithelial / Disease state, Lineage and Cell class	LYPD2 IRAK3 ECE1 MUC5AC	1.96e-04	191	67	4	267e1192aaec468c1a59eb24848b37e0e18cbc44
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	1.96e-04	191	67	4	e14b22e882ac92acf8c8b6ee997ef8e799c7a8d5
ToppCell	normal-na-Myeloid-non-classical_monocyte-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	LYPD2 IRAK3 LTA4H ADGRE2	2.04e-04	193	67	4	053adc7ed9f997b503e12239a684bb9f5896e10c
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LYPD2 ADGRE2 ECE1 TNFRSF21	2.04e-04	193	67	4	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LY6D LYPD2 ECE1 MUC5AC	2.04e-04	193	67	4	8ede7038a222c7e7ecaf7e86520823cf606cbee7
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LY6D LYPD2 ECE1 MUC5AC	2.04e-04	193	67	4	0e7d7adfaa7191e34038fcda6677561ae13934eb
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D OSBPL3 JAG1 TNFRSF21	2.08e-04	194	67	4	1531dcace28a14bd700e909a027426a8cee20337
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLK1 TNFRSF21 GFRA1 KRT80	2.08e-04	194	67	4	70185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LYPD2 IRAK3 LTA4H ADGRE2	2.08e-04	194	67	4	b191851b2287afc8c47320f5488fd22e2a454aa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLI1 LYPD2 IRAK3 ADGRE2	2.12e-04	195	67	4	1d58585557bf8e9ce4d514e128d3a902b526331d
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D LYPD2 ECE1 MUC5AC	2.12e-04	195	67	4	2a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	2.12e-04	195	67	4	d7e92bcbd05b93e86a1e1397e44ad27a9e2e637a
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLURP1 LYPD2 MUC5AC KIF24	2.12e-04	195	67	4	e525b69145059b66417589601f7109af63730f3a
ToppCell	MNPs-Monocytes\|MNPs / lung cells shred on cell class, cell subclass, sample id	LYPD2 GIMAP7 ADGRE2 ECE1	2.12e-04	195	67	4	45e8d27287bdfd07d7e944ae5d3f44d05c33468f
ToppCell	3'-Airway_Nasal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	2.12e-04	195	67	4	7ffbdbe95b248699bf6300322d084d21a4a4b1b8
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	IRAK3 ADGRE2 ECE1 TNFRSF21	2.12e-04	195	67	4	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	Nasal_Brush-Epithelial-Goblet_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	LY6D SLURP1 LYPD2 MUC5AC	2.16e-04	196	67	4	e16f0831f1f677b28e4a8014f0aede7e713d4f04
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	FLI1 IRAK3 LTA4H ADGRE2	2.16e-04	196	67	4	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLI1 LAMC1 GIMAP7 SLC30A1	2.16e-04	196	67	4	889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCell	3'-Airway_Nasal-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D SLURP1 LYPD2 MUC5AC	2.16e-04	196	67	4	eadc3e60104214cb5f6cfb098a5c5ea0f83d15bd
ToppCell	Nasal_Brush-Epithelial-Goblet_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	LY6D SLURP1 LYPD2 MUC5AC	2.16e-04	196	67	4	71e88d9ca28168732bd91f2d4f8f53bb4187963a
ToppCell	10x5'-Liver-Myeloid_Monocytic-Nonclassical_monocytes\|Liver / Manually curated celltypes from each tissue	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	b0b4a704e1137f48e2258df17285ed89684ae98d
ToppCell	PBMC-Mild-Myeloid-Non-classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	083fec147040ee0bebac2815fb89355cf3a7ffa5
ToppCell	PBMC-Mild-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	f0e6745b0fd734ea17e7a2a883e48017e8d3102d
ToppCell	PBMC-Mild-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	b82142cf8057a55dfa884248b752173661edffd1
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D LYPD2 TNFRSF21 MUC5AC	2.20e-04	197	67	4	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	PBMC-Mild-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	96d56bce69de7192c7a6b43371b56f4acdcc7733
ToppCell	PBMC-Mild-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	70faaea9c143337a52c8f660ebb063aa92327357
ToppCell	PBMC-Mild-Myeloid-Non-classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	422074930fce25a6ad15ba41e391c65787e7878e
ToppCell	COVID-19_Mild-Myeloid-Non-classical_Monocyte\|COVID-19_Mild / Disease group, lineage and cell class	LYPD2 IRAK3 LTA4H ADGRE2	2.20e-04	197	67	4	9c943d18f8e6cb0ce9f2158d50796fafae5c81d4
ToppCell	Bronchial_Brush-Epithelial-Club\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	LY6D LYPD2 ECE1 MUC5AC	2.25e-04	198	67	4	61292a2b5aacb6080a679a31b70a211bdec59a3b
ToppCell	distal-Endothelial-Bronchial_Vessel_1-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLI1 CDH24 LAMC1 GIMAP7	2.25e-04	198	67	4	5bdffabf80716dd80c1265c3d126c7a25340251c
Disease	pancreatic cancer (is_marker_for)	ALB RET MUC5AC SMAD2	5.09e-05	101	59	4	DOID:1793 (is_marker_for)
Disease	Tetralogy of Fallot	JAG1 GATA4	5.87e-05	6	59	2	cv:C0039685
Disease	Aganglionic megacolon	RET ECE1	5.87e-05	6	59	2	cv:C0019569
Disease	TETRALOGY OF FALLOT	JAG1 GATA4	5.87e-05	6	59	2	187500
Disease	pulmonary fibrosis (biomarker_via_orthology)	JAG1 MUC5AC HSP90AB1	1.39e-04	50	59	3	DOID:3770 (biomarker_via_orthology)
Disease	Hirschsprung's disease (implicated_via_orthology)	RET GFRA1	2.56e-04	12	59	2	DOID:10487 (implicated_via_orthology)
Disease	tetralogy of Fallot (is_implicated_in)	JAG1 GATA4	3.02e-04	13	59	2	DOID:6419 (is_implicated_in)
Disease	Aganglionosis, Rectosigmoid Colon	RET ECE1	4.06e-04	15	59	2	C1257840
Disease	Aganglionosis, Colonic	RET ECE1	4.06e-04	15	59	2	C0085758
Disease	Tetralogy of Fallot	JAG1 GATA4	4.63e-04	16	59	2	C0039685
Disease	Congenital Intestinal Aganglionosis	RET ECE1	5.24e-04	17	59	2	C3661523
Disease	Left Ventricle Remodeling	GATA4 SMAD2	8.05e-04	21	59	2	C0600520
Disease	Ventricular Remodeling	GATA4 SMAD2	8.05e-04	21	59	2	C0600519
Disease	congenital heart disease (is_implicated_in)	JAG1 GATA4	1.05e-03	24	59	2	DOID:1682 (is_implicated_in)
Disease	pathological myopia	FLI1 GATA4 PML	1.44e-03	111	59	3	EFO_0004207
Disease	Drug-Induced Stevens Johnson Syndrome	ALB PML	1.54e-03	29	59	2	C1274933
Disease	Toxic Epidermal Necrolysis	ALB PML	1.54e-03	29	59	2	C0014518
Disease	Mycoplasma-Induced Stevens-Johnson Syndrome	ALB PML	1.54e-03	29	59	2	C3658301
Disease	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	ALB PML	1.54e-03	29	59	2	C3658302
Disease	Stevens-Johnson Syndrome	ALB PML	1.65e-03	30	59	2	C0038325
Disease	Hirschsprung Disease	RET ECE1	1.76e-03	31	59	2	C0019569

Protein segments in the cluster

Peptide	Gene	Start	Entry
CRAQAPSSTISLVSC	ADGRF3	1036	Q8IZF5
TPVSDRVTKCCTESL	ALB	491	P02768
STIGTRDTSTICRCT	ADGRE2	501	Q9UHX3
LACQSKCPRIVSTSL	ARFGEF1	86	Q9Y6D6
CQSKSPRVVSTSLDC	ARFGEF2	76	Q9Y6D5
IDKTCSRPVTNCASS	DLK1	201	P80370
KENKLCTPVICSSST	CCDC14	821	Q49A88
SRACRAKSTPSTCES	ANKRD6	521	Q9Y2G4
PVTSSSVASQSCLRK	CCDC27	211	Q2M243
IPSTSQRTKAFSTCS	OR6C1	226	Q96RD1
DTCSLASPASVCRTK	LTA4H	6	P09960
TSSNKSTCPLCRETF	LTN1	1751	O94822
ACSLVKPTLVCSSAV	PCDHA7	731	Q9UN72
EKVTISNRLVSSPCC	HSP90AB1	576	P08238
SNRLVSSPCCIVTST	HSP90AB1	581	P08238
SPSATVVSAVQSRCK	KRT80	396	Q6KB66
STATVTVSVCRCQPD	CDH24	606	Q86UP0
CNLPSTTKRKCASSS	PER1	641	O15534
GTSCTVSTDCQTVVR	PGLYRP3	211	Q96LB9
KCCTSVTSRNRTSGN	KIF24	551	Q5T7B8
TCVQVACVTNTSKSP	MUC5AC	5446	P98088
SCRSRPVESSCSSKF	IRAK3	571	Q9Y616
TVCTSCKRLLPLATT	OTUD7A	191	Q8TE49
PTGVSDCVTIATCTT	LYPD2	31	Q6UXB3
SSQRVCSPCTTIKAT	MAGEA13P	66	A6NCF6
RVGLSCANCQTTTTT	GATA4	266	P43694
QKSSSSRPSCSCLVA	KLRG1	26	Q96E93
ERKVSIPSCCVSFAT	C2CD3	1656	Q4AC94
TPCTTSVSNDVCNRR	GFRA1	176	P56159
SRESPVDCSVSKCSK	FLI1	76	Q01543
AQCSCVVIRTSKSLP	DGKB	741	Q9Y6T7
VVCPASSRFCKTTNT	LY6D	36	Q14210
LTRCCKNIPSNATSV	IGHE	11	P01854
SRQTTCISNPCSTTY	KRTAP11-1	86	Q8IUC1
KSAVCVPVSCQSSVC	KRTAP12-2	71	P59991
KTKEVVCTNCPTGTT	LAMC1	786	P11047
TTCCRTTCWQPTIVT	KRTAP9-6	16	A8MVA2
SSRKCFSVPATSLCS	KRTAP16-1	6	A8MUX0
STSSQLDCVDTTPCK	KRTAP16-1	466	A8MUX0
PSVCLSEACVSVTSS	ECE1	96	P42892
SQKLVSPSRSTSSCS	OSBPL3	11	Q9H4L5
CRSSSLQPVKTKCTS	JAG1	936	P78504
STNRASFKCPVCSST	GTF2E1	121	P29083
CPFCSKITRITSLTQ	TRIM32	61	Q13049
TNTSLRVCSSCPVGT	TNFRSF21	81	O75509
TTTAQKRKCSQTQCP	PML	471	P29590
TTCKEISRCIISSCP	GIMAP7	76	Q8NHV1
CRSCLENSSRPTSTI	POLR2B	221	P30876
SPVVTRSCSSSCVAT	SLURP1	66	P55000
CRSKLTSCSSLSPQR	STARD9	821	Q9P2P6
TSCTKRDNLRPTCTQ	TRIOBP	836	Q9H2D6
CTSPTSQSCSSGKRL	STXBP5L	756	Q9Y2K9
QTTECLTPESCSQTT	ANKHD1	1016	Q8IWZ3
SSIPCQTTLAVTVAC	CLDND2	51	Q8NHS1
ASSVSTAQRISCRPK	ZNF525	171	Q8N782
SRCPVSTCNRLFTSK	ZXDC	451	Q2QGD7
TTQNCNTKCVTIPST	SMAD2	66	Q15796
CNTTLSSPAESCRSK	STYXL2	801	Q5VZP5
TPTTTQLSCKICIRQ	UNC5D	796	Q6UXZ4
ASSISTSQRISCRPK	ZNF813	171	Q6ZN06
SCLCSQPSVTRTVQK	TOP3A	896	Q13472
ITRNFSTCSPSTKTC	RET	551	P07949
QQCVSPSSSLCRKTT	ZNF507	191	Q8TCN5
ASSVSTSQRICCRPK	ZNF28	171	P17035
STPKSESIQTDCSCR	XKR5	661	Q6UX68
SKSSVVPCELACRTQ	SLC30A1	426	Q9Y6M5
SGQVPCSCTKSTLRK	TSPAN19	171	P0C672
ASSVSTSQRICCRPK	ZNF468	171	Q5VIY5
LCTSAVSPNTTKATR	KIAA1958	411	Q8N8K9