Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ephrin receptor activity	EPHB2 EPHB4 EFNA3	5.73e-05	19	80	3	GO:0005003
GeneOntologyBiologicalProcess	ephrin receptor signaling pathway	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.86e-06	54	78	5	GO:0048013
GeneOntologyBiologicalProcess	axon guidance	EPHB2 EFNA1 EFNA3 EFNA5 SEMA3B LRP1 ECE1 PALLD	1.22e-05	285	78	8	GO:0007411
GeneOntologyBiologicalProcess	neuron projection guidance	EPHB2 EFNA1 EFNA3 EFNA5 SEMA3B LRP1 ECE1 PALLD	1.25e-05	286	78	8	GO:0097485
GeneOntologyBiologicalProcess	tube development	EPHB2 EPHB4 MST1 CCN6 GAK EFNA1 EFNA3 NF1 GLI1 CSPG4 LRP1 ETV2 COBL CALCRL ECE1 FZD2 NOS3	1.52e-05	1402	78	17	GO:0035295
GeneOntologyBiologicalProcess	tube morphogenesis	EPHB2 EPHB4 MST1 CCN6 EFNA1 EFNA3 NF1 GLI1 CSPG4 LRP1 ETV2 COBL CALCRL FZD2 NOS3	1.75e-05	1125	78	15	GO:0035239
GeneOntologyBiologicalProcess	notochord development	EFNA1 GLI1 COBL	9.94e-05	24	78	3	GO:0030903
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by endothelin	ECE1 NOS3	2.10e-04	6	78	2	GO:0003100
GeneOntologyBiologicalProcess	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	EFNA1 EFNA3	2.10e-04	6	78	2	GO:1902961
GeneOntologyBiologicalProcess	blood vessel morphogenesis	EPHB2 EPHB4 CCN6 EFNA1 EFNA3 NF1 CSPG4 LRP1 ETV2 CALCRL NOS3	2.43e-04	817	78	11	GO:0048514
GeneOntologyBiologicalProcess	axonogenesis	EPHB2 EFNA1 EFNA3 EFNA5 SEMA3B LRP1 COBL ECE1 PALLD	2.80e-04	566	78	9	GO:0007409
GeneOntologyBiologicalProcess	circulatory system development	EPHB2 EPHB4 CCN6 PRICKLE4 EFNA1 EFNA3 NF1 GLI1 CSPG4 LRP1 ETV2 CALCRL ECE1 FZD2 NOS3	2.88e-04	1442	78	15	GO:0072359
GeneOntologyBiologicalProcess	positive regulation of aspartic-type peptidase activity	EFNA1 EFNA3	2.93e-04	7	78	2	GO:1905247
Domain	Ephrin_RBD	EFNA1 EFNA3 EFNA5	3.87e-06	8	78	3	IPR001799
Domain	Ephrin	EFNA1 EFNA3 EFNA5	3.87e-06	8	78	3	PF00812
Domain	Ephrin	EFNA1 EFNA3 EFNA5	3.87e-06	8	78	3	PD002533
Domain	Ephrin	EFNA1 EFNA3 EFNA5	3.87e-06	8	78	3	IPR031328
Domain	EPHRIN_RBD_1	EFNA1 EFNA3 EFNA5	3.87e-06	8	78	3	PS01299
Domain	Ephrin_CS	EFNA1 EFNA3 EFNA5	3.87e-06	8	78	3	IPR019765
Domain	EPHRIN_RBD_2	EFNA1 EFNA3 EFNA5	3.87e-06	8	78	3	PS51551
Domain	-	EFNA1 EFNA3 EFNA5	2.47e-05	14	78	3	2.60.40.420
Domain	Cupredoxin	EFNA1 EFNA3 EFNA5	1.02e-04	22	78	3	IPR008972
Domain	Ephrin_rec_like	EPHB2 EPHB4	9.24e-04	11	78	2	PF07699
Domain	RECEPTOR_TYR_KIN_V_2	EPHB2 EPHB4	1.52e-03	14	78	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB2 EPHB4	1.52e-03	14	78	2	PS00790
Domain	Eph_TM	EPHB2 EPHB4	1.52e-03	14	78	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB2 EPHB4	1.52e-03	14	78	2	IPR001426
Domain	EPH_lbd	EPHB2 EPHB4	1.52e-03	14	78	2	SM00615
Domain	Ephrin_lbd	EPHB2 EPHB4	1.52e-03	14	78	2	PF01404
Domain	EphA2_TM	EPHB2 EPHB4	1.52e-03	14	78	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB2 EPHB4	1.52e-03	14	78	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB2 EPHB4	1.52e-03	14	78	2	IPR001090
Domain	EPH_LBD	EPHB2 EPHB4	1.52e-03	14	78	2	PS51550
Domain	GPCR_2_secretin-like	CALCRL FZD2 PTH2R	2.02e-03	60	78	3	IPR000832
Domain	GPCR_2-like	CALCRL FZD2 PTH2R	2.02e-03	60	78	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	CALCRL FZD2 PTH2R	2.12e-03	61	78	3	PS50261
Domain	Growth_fac_rcpt_	EPHB2 EPHB4 CCN6 LRP1	4.14e-03	156	78	4	IPR009030
Domain	Ephrin_rec_like	EPHB2 EPHB4	4.85e-03	25	78	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB2 EPHB4	4.85e-03	25	78	2	IPR011641
Domain	HormR	CALCRL PTH2R	4.85e-03	25	78	2	SM00008
Domain	SPRY	RANBP10 TRIML1 SPSB2	5.77e-03	87	78	3	SM00449
Domain	HRM	CALCRL PTH2R	6.07e-03	28	78	2	PF02793
Domain	SPRY	RANBP10 TRIML1 SPSB2	7.15e-03	94	78	3	PF00622
Domain	SPRY_dom	RANBP10 TRIML1 SPSB2	7.15e-03	94	78	3	IPR003877
Domain	B30.2/SPRY	RANBP10 TRIML1 SPSB2	7.36e-03	95	78	3	IPR001870
Domain	B302_SPRY	RANBP10 TRIML1 SPSB2	7.36e-03	95	78	3	PS50188
Pathway	REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	2.10e-07	34	56	5	MM15025
Pathway	REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.68e-06	51	56	5	M27311
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	5.68e-06	65	56	5	MM14911
Pathway	KEGG_AXON_GUIDANCE	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5 SEMA3B	1.17e-05	129	56	6	M5539
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	3.12e-05	92	56	5	M27201
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	EFNA1 EFNA3 EFNA5	4.64e-05	18	56	3	MM15023
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	EFNA1 EFNA3 EFNA5	2.02e-04	29	56	3	M27309
Pathway	WP_ENDOTHELIN_PATHWAYS	CALCRL ECE1 NOS3	2.98e-04	33	56	3	M39651
Pathway	PID_EPHA_FWDPATHWAY	EFNA1 EFNA3 EFNA5	3.26e-04	34	56	3	M177
Pathway	PID_EPHB_FWD_PATHWAY	EPHB2 EPHB4 EFNA5	5.29e-04	40	56	3	M62
Pubmed	Expression of Ephs and ephrins in developing mouse inner ear.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	6.85e-10	19	81	5	12684176
Pubmed	Multiple roles of EPH receptors and ephrins in neural development.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	9.12e-10	20	81	5	11256076
Pubmed	Eph receptors and ephrins: effectors of morphogenesis.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	9.12e-10	20	81	5	10207129
Pubmed	The ephrins and Eph receptors in neural development.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	9.12e-10	20	81	5	9530499
Pubmed	The Eph family receptors and ligands.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	9.12e-10	20	81	5	9576626
Pubmed	Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.19e-09	21	81	5	9267020
Pubmed	Roles of Eph receptors and ephrins in segmental patterning.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.19e-09	21	81	5	11128993
Pubmed	Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.19e-09	21	81	5	10495276
Pubmed	Developmental expression of Eph and ephrin family genes in mammalian small intestine.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.19e-09	21	81	5	20112066
Pubmed	Eph receptors and ephrins: regulators of guidance and assembly.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.19e-09	21	81	5	10730216
Pubmed	Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.97e-09	23	81	5	19542359
Pubmed	Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	2.48e-09	24	81	5	16446123
Pubmed	Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling.	EPHB2 EFNA1 EFNA3 EFNA5	3.65e-08	15	81	4	26839344
Pubmed	Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	4.81e-08	42	81	5	11439183
Pubmed	Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.	EPHB2 EFNA1 EFNA3 EFNA5	4.86e-08	16	81	4	8755474
Pubmed	Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse.	EPHB2 EPHB4 EFNA1 EFNA3 EFNA5	1.31e-07	51	81	5	19769959
Pubmed	The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.	EFNA1 EFNA3 EFNA5	2.42e-07	6	81	3	9053851
Pubmed	Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.	EFNA1 EFNA3 EFNA5	2.42e-07	6	81	3	15777695
Pubmed	Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum.	EFNA1 EFNA3 EFNA5	4.23e-07	7	81	3	10366629
Pubmed	Molecular development of sensory maps: representing sights and smells in the brain.	EFNA1 EFNA3 EFNA5	4.23e-07	7	81	3	9988220
Pubmed	Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis.	EFNA1 EFNA3 EFNA5	4.23e-07	7	81	3	8903354
Pubmed	Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor.	EFNA1 EFNA3 EFNA5	4.23e-07	7	81	3	9195962
Pubmed	Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues.	EFNA1 EFNA3 EFNA5	4.23e-07	7	81	3	11519828
Pubmed	Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach.	EFNA1 EFNA3 EFNA5	6.76e-07	8	81	3	22568954
Pubmed	Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.	EFNA1 EFNA3 EFNA5	6.76e-07	8	81	3	10774725
Pubmed	Topographic guidance labels in a sensory projection to the forebrain.	EFNA1 EFNA3 EFNA5	1.01e-06	9	81	3	9883724
Pubmed	EphB signaling regulates target innervation in the developing and deafferented auditory brainstem.	EPHB2 EPHB4 EFNA5	1.44e-06	10	81	3	22021100
Pubmed	Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers.	EFNA1 EFNA3 EFNA5	1.44e-06	10	81	3	10719886
Pubmed	Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5.	EFNA1 EFNA3 EFNA5	1.98e-06	11	81	3	10559410
Pubmed	Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues.	EFNA1 EFNA3 EFNA5	1.98e-06	11	81	3	15517401
Pubmed	EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.	EFNA1 EFNA3 EFNA5	2.64e-06	12	81	3	19247962
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EFNA1 EFNA3 EFNA5	3.42e-06	13	81	3	17039519
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EFNA1 EFNA3 EFNA5	3.42e-06	13	81	3	12528186
Pubmed	Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.	EFNA1 EFNA3 EFNA5	4.35e-06	14	81	3	34235739
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHB4 EFNA1 EFNA3	4.35e-06	14	81	3	26941654
Pubmed	Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase.	EPHB4 NOS3	5.36e-06	2	81	2	26817610
Pubmed	Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.	EFNA3 EFNA5	5.36e-06	2	81	2	15901737
Pubmed	Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.	EPHB2 EFNA5	5.36e-06	2	81	2	15107857
Pubmed	Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients.	EPHB2 EPHB4	5.36e-06	2	81	2	22374425
Pubmed	EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling.	EPHB2 EPHB4	5.36e-06	2	81	2	16840724
Pubmed	Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC.	GLI1 ADAR	5.36e-06	2	81	2	36683360
Pubmed	Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis.	CSPG4 NOS3	5.36e-06	2	81	2	20431061
Pubmed	The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth.	EPHB2 EPHB4	5.36e-06	2	81	2	19597185
Pubmed	Ephrin-A1 is up-regulated by hypoxia in cancer cells and promotes angiogenesis of HUVECs through a coordinated cross-talk with eNOS.	EFNA1 NOS3	5.36e-06	2	81	2	24040255
Pubmed	Dysregulation of the EphrinB2-EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell dysfunction in vitro and functions as a novel noninvasive biomarker in patients.	EPHB2 EPHB4	5.36e-06	2	81	2	32286515
Pubmed	Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme.	GLI1 NOS3	5.36e-06	2	81	2	11821712
Pubmed	The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder.	EPHB2 EPHB4	5.36e-06	2	81	2	25148033
Pubmed	Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.	EPHB2 EPHB4	5.36e-06	2	81	2	34360793
Pubmed	Disturbed Expression of EphB4, but Not EphrinB2, Inhibited Bone Regeneration in an In Vivo Inflammatory Microenvironment.	EPHB2 EPHB4	5.36e-06	2	81	2	28077917
Pubmed	Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.	EPHB2 EPHB4	5.36e-06	2	81	2	36519465
Pubmed	Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression.	EPHB2 EPHB4	5.36e-06	2	81	2	19366806
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	EPHB2 EFNA3 LRRC3B SEMA3B FZD2	8.26e-06	117	81	5	17145500
Pubmed	Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.	EFNA1 EFNA3 EFNA5	9.68e-06	18	81	3	22243746
Pubmed	Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity.	EPHB2 EPHB4 CSPG4	9.68e-06	18	81	3	18651661
Pubmed	Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting.	EPHB2 EPHB4 EFNA1	1.15e-05	19	81	3	35294885
Pubmed	Completing the structural family portrait of the human EphB tyrosine kinase domains.	EPHB2 EPHB4	1.60e-05	3	81	2	24677421
Pubmed	Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomers.	EFNA1 EFNA5	1.60e-05	3	81	2	17707797
Pubmed	Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.	EFNA1 EFNA3	1.60e-05	3	81	2	7838529
Pubmed	Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.	LRP1 NOS3	1.60e-05	3	81	2	21540184
Pubmed	Expression and localisation of ephrin-B1, EphB2, and EphB4 in the mouse testis during postnatal development.	EPHB2 EPHB4	1.60e-05	3	81	2	32620380
Pubmed	Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.	EPHB2 EPHB4	1.60e-05	3	81	2	34296545
Pubmed	Protein tyrosine kinases transcribed in a murine thymic medullary epithelial cell line.	EPHB2 EPHB4	1.60e-05	3	81	2	8206383
Pubmed	Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development.	EFNA1 EFNA3	1.60e-05	3	81	2	16466970
Pubmed	Architecture of Eph receptor clusters.	EFNA1 EFNA5	1.60e-05	3	81	2	20505120
Pubmed	Ephrin-B2-EphB4 communication mediates tumor-endothelial cell interactions during hematogenous spread to spinal bone in a melanoma metastasis model.	EPHB2 EPHB4	1.60e-05	3	81	2	32989254
Pubmed	Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping.	EFNA3 EFNA5	1.60e-05	3	81	2	16025107
Pubmed	Ephrin-as guide the formation of functional maps in the visual cortex.	EFNA3 EFNA5	1.60e-05	3	81	2	16301175
Pubmed	EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.	EPHB2 EPHB4	1.60e-05	3	81	2	15722342
Pubmed	Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.	EPHB2 EPHB4	1.60e-05	3	81	2	21092311
Pubmed	Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map.	EFNA3 EFNA5	1.60e-05	3	81	2	12914696
Pubmed	Notch ligand Delta-like 1 is essential for postnatal arteriogenesis.	EPHB2 EPHB4	1.60e-05	3	81	2	17234965
Pubmed	GLI1+ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue.	GLI1 DCT	1.60e-05	3	81	2	27585489
Pubmed	Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells.	NF1 CSPG4 DCT	2.38e-05	24	81	3	30348676
Pubmed	Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes.	EPHB2 EPHB4	3.20e-05	4	81	2	18957513
Pubmed	ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy.	ATG16L2 TECPR1	3.20e-05	4	81	2	31636955
Pubmed	Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival.	NF1 DCT	3.20e-05	4	81	2	11401406
Pubmed	Eph and ephrin expression in normal placental development and preeclampsia.	EPHB4 EFNA1	3.20e-05	4	81	2	15193868
Pubmed	Alignment of multimodal sensory input in the superior colliculus through a gradient-matching mechanism.	EFNA3 EFNA5	3.20e-05	4	81	2	22496572
Pubmed	Ephrin-As and patterned retinal activity act together in the development of topographic maps in the primary visual system.	EFNA3 EFNA5	3.20e-05	4	81	2	17167078
Pubmed	EphA3 null mutants do not demonstrate motor axon guidance defects.	EFNA3 EFNA5	3.20e-05	4	81	2	14585969
Pubmed	Ephrin-B stimulation of calvarial bone formation.	EPHB2 EPHB4	3.20e-05	4	81	2	23129351
Pubmed	EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions.	EFNA1 EFNA3	3.20e-05	4	81	2	17980912
Pubmed	NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma.	NF1 CSPG4	3.20e-05	4	81	2	23318450
Pubmed	Roles of ephrin-as and structured activity in the development of functional maps in the superior colliculus.	EFNA3 EFNA5	3.20e-05	4	81	2	18945909
Pubmed	Endothelial Cyp26b1 restrains murine heart valve growth during development.	SHROOM1 GRINA ECE1 FZD2 NOS3	4.09e-05	163	81	5	35364055
Pubmed	Noggin is required for correct guidance of dorsal root ganglion axons.	EPHB2 EPHB4 SEMA3B	4.26e-05	29	81	3	12435358
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	EPHB2 EPHB4 GAK EFNA1 EFNA5 NF1 C15orf61 CHD2 PALLD ATG16L2	5.02e-05	910	81	10	36736316
Pubmed	The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma.	EFNA1 EFNA5	5.33e-05	5	81	2	22036564
Pubmed	Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.	EFNA1 EFNA3	5.33e-05	5	81	2	24217950
Pubmed	An NF-κB--EphrinA5-Dependent Communication between NG2(+) Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates.	EFNA5 CSPG4	5.33e-05	5	81	2	26777211
Pubmed	Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF).	EPHB2 EPHB4	5.33e-05	5	81	2	12048246
Pubmed	EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase.	EPHB2 EPHB4	5.33e-05	5	81	2	11983165
Pubmed	Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4.	EPHB2 EPHB4	7.99e-05	6	81	2	9630219
Pubmed	Polysialylated NCAM and ephrinA/EphA regulate synaptic development of GABAergic interneurons in prefrontal cortex.	EFNA3 EFNA5	7.99e-05	6	81	2	22275477
Pubmed	EphA4 is necessary for spatially selective peripheral somatosensory topography.	EFNA3 EFNA5	7.99e-05	6	81	2	20014408
Pubmed	Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina.	EFNA3 EFNA5	7.99e-05	6	81	2	8954746
Pubmed	Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.	EFNA1 EFNA3	7.99e-05	6	81	2	7973638
Pubmed	Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.	LRP1 GRINA	1.12e-04	7	81	2	23267846
Pubmed	Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor.	EPHB4 NOS3	1.12e-04	7	81	2	27356767
Pubmed	Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.	EPHB2 EPHB4	1.12e-04	7	81	2	9990854
Interaction	EPHB1 interactions	EPHB2 EPHB4 EFNA1 EFNA5	5.73e-06	31	77	4	int:EPHB1
Interaction	EPHA6 interactions	EPHB2 EPHB4 EFNA1 EFNA5	2.61e-05	45	77	4	int:EPHA6
GeneFamily	Ephrins	EFNA1 EFNA3 EFNA5	8.55e-07	8	46	3	546
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB2 EPHB4	5.65e-04	14	46	2	1095
ToppCell	droplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOC2A EPHB4 EFNA1 EFNA5 CALCRL ECE1 NOS3	4.77e-08	185	81	7	eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFNA1 EFNA3 EFNA5 LRRC3B ECE1 NOS3	1.02e-06	182	81	6	aa113a0d2c1d28bda24cbb1221afd21b5628dc6d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 P4HA2 SLC5A10 CHDH ZNF804B PTH2R	1.05e-06	183	81	6	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOC2A EPHB4 EFNA1 CALCRL ECE1 NOS3	1.16e-06	186	81	6	b80aaeebc03a318052076d2f02c123f5ddc5e73a
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOC2A EPHB4 EFNA1 CALCRL ECE1 NOS3	1.16e-06	186	81	6	8a8ed1502542d4895cba3fd5d534256206578716
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 EFNA5 CALCRL ECE1 TOX2 NOS3	1.27e-06	189	81	6	9da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPHB4 EFNA1 CALCRL ECE1 TOX2 NOS3	1.27e-06	189	81	6	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 EFNA5 CALCRL ECE1 TOX2 NOS3	1.35e-06	191	81	6	3307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 PRICKLE4 CALCRL ECE1 NOS3	1.13e-05	161	81	5	f4f5d6eaa32169de699c8ff8e8ae35179c8e25c0
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	EPHB4 CALCRL ECE1 TOX2 NOS3	1.39e-05	168	81	5	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P4HA2 LRRC3B COBL IZUMO1R TOX2	1.43e-05	169	81	5	3ad534303b4b60a77d171e605a1ba2ef20b5e2a3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P4HA2 LRRC3B COBL IZUMO1R TOX2	1.43e-05	169	81	5	29dca061864c86218ab73a86cf6e3c522472da47
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	EFNA1 CALCRL ECE1 TOX2 NOS3	1.60e-05	173	81	5	ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	EFNA1 CALCRL ECE1 TOX2 NOS3	1.60e-05	173	81	5	22200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB4 LRRC3B CALCRL TOX2 NOS3	1.65e-05	174	81	5	40bb87d219aafab0357ab0d797efd38085fc0312
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM1 LRRC3B CALCRL ECE1 TOX2	1.65e-05	174	81	5	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 IP6K3 CALCRL ECE1 NOS3	1.70e-05	175	81	5	2e54961846c65b185d9bd6e305dd81205579d890
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 IP6K3 CALCRL ECE1 NOS3	1.70e-05	175	81	5	efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC3B CALCRL ECE1 TOX2 NOS3	1.74e-05	176	81	5	96779273b94345250cf53ba671203345b43d9e00
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	EPHB4 EFNA1 CALCRL ECE1 TECPR1	1.79e-05	177	81	5	6da88c358b3a2e47fa3472217a38b6b00ad7b280
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	1.99e-05	181	81	5	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 CALCRL ECE1 TOX2 NOS3	1.99e-05	181	81	5	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	1.99e-05	181	81	5	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 CALCRL ECE1 TOX2 NOS3	2.10e-05	183	81	5	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	2.10e-05	183	81	5	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 P4HA2 SLC5A10 CHDH ZNF804B	2.16e-05	184	81	5	9434731f651820b05335085582960f08fbf895de
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 EFNA1 CALCRL ECE1 NOS3	2.27e-05	186	81	5	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	2.27e-05	186	81	5	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH COBL PTH2R	2.33e-05	187	81	5	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	2.33e-05	187	81	5	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFNA1 EFNA5 CALCRL ECE1 NOS3	2.33e-05	187	81	5	12129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	2.33e-05	187	81	5	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFNA1 EFNA5 CALCRL ECE1 NOS3	2.33e-05	187	81	5	83930ef55191eff9006113feaeabb3c2fa21fd05
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	2.33e-05	187	81	5	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFNA1 IGLL1 CALCRL ECE1 NOS3	2.33e-05	187	81	5	7170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	2.39e-05	188	81	5	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P4HA2 SLC5A10 CHDH ZNF804B PTH2R	2.39e-05	188	81	5	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 CALCRL ECE1 TOX2 NOS3	2.45e-05	189	81	5	d17e8467699c7ca7694a313c26111f085df5204e
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 EFNA5 CALCRL ECE1 NOS3	2.52e-05	190	81	5	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	facs-Thymus-Epithelium-24m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFNA1 EFNA3 EFNA5 CSPG4 PALLD	2.58e-05	191	81	5	eec14997d2bfc7e6b5a601afc43a147f6b96d668
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFNA1 EFNA3 EFNA5 CSPG4 PALLD	2.58e-05	191	81	5	1730ec5dc1cfd2f0cba7e21555641c7bce97e09d
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFNA1 EFNA5 CALCRL ECE1 NOS3	2.58e-05	191	81	5	6e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFNA1 EFNA5 CALCRL ECE1 NOS3	2.58e-05	191	81	5	482db995930346be69072ace2fd78fd453e97fb5
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFNA1 EFNA3 EFNA5 CSPG4 PALLD	2.58e-05	191	81	5	4b77abc68bd72c64e7062f9527fe9d9605289ceb
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 EFNA1 CALCRL ECE1 NOS3	2.58e-05	191	81	5	b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 EFNA1 CALCRL ECE1 NOS3	2.58e-05	191	81	5	27f23c2254b610abac1a88d0fecff305addde9da
ToppCell	P07-Endothelial-large_vessel_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPHB4 EFNA1 CALCRL ECE1 NOS3	2.58e-05	191	81	5	d162917816dd2e4767c97447c1cddae9397713ab
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 EFNA5 CALCRL ECE1 NOS3	2.65e-05	192	81	5	285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell	EC\|World / Lineage and Cell class	EPHB4 EFNA1 LRRC3B ECE1 NOS3	2.65e-05	192	81	5	478866dd5b0d6ff3a76d07a17c4b5989dd7a27bb
ToppCell	LAM-Endothelial-LymEndo\|LAM / Condition, Lineage and Cell class	EPHB4 EFNA5 LRCOL1 CALCRL NOS3	2.71e-05	193	81	5	68eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCell	EC-Arteriolar_ECs\|World / Lineage and Cell class	EFNA1 LRRC3B ECE1 TOX2 NOS3	2.78e-05	194	81	5	38f0c52de252101d4bc8633af80002061635e487
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSF3R LRP1 CRISP3 GRINA ATG16L2	2.85e-05	195	81	5	b0dbaae86f5703ab62f925e0f36500274044884a
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CCN6 GLI1 CSPG4 LRP1 FZD2	2.99e-05	197	81	5	2cb1f557ce1400398975de94638126b4522567f3
ToppCell	medial-Endothelial-Artery\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EFNA1 CALCRL ECE1 TOX2 NOS3	3.14e-05	199	81	5	341c0be18bec66f4cc8bda232dce54edb34b9cda
ToppCell	medial-2-Endothelial-Artery\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EFNA1 CALCRL ECE1 TOX2 NOS3	3.14e-05	199	81	5	53c17c0493f82351a039bc64def191311e0f4951
ToppCell	medial-Endothelial-Artery-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EFNA1 CALCRL ECE1 TOX2 NOS3	3.14e-05	199	81	5	c455f5a2802f2ec6f0e24266de1aaf3203ca8c78
ToppCell	distal-2-Endothelial-Artery\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CALCRL ECE1 TOX2 NOS3 PALLD	3.14e-05	199	81	5	fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM1 CALCRL ECE1 TOX2 NOS3	3.22e-05	200	81	5	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	EPHB4 EFNA1 EFNA5 LRCOL1 CALCRL	3.22e-05	200	81	5	b515b2ab0c3f5928dd67f2f227fc932451c272bb
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Vein\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHB4 SCAF11 CALCRL ECE1 NOS3	3.22e-05	200	81	5	b3f93b71589251197cde96b7bc6d065c106f61cd
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	EPHB4 EFNA1 EFNA5 LRCOL1 CALCRL	3.22e-05	200	81	5	35f6c7f2469d12748c27f2a5d4a161ef839b4a07
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	CALCRL ECE1 TOX2 NOS3 PALLD	3.22e-05	200	81	5	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	EFNA1 CALCRL ECE1 NOS3	1.24e-04	140	81	4	b9aeb7dda7f377b580dd8a44912f300721437387
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK2 IGLL1 IZUMO1R TOX2	1.54e-04	148	81	4	d44f6c5fc8d1fce4046598030a48fa57ed520a6a
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	LRRIQ3 CSF3R GLI1 ETV2	1.79e-04	154	81	4	1c62290a2558fd6401b27de5a867d243b143b00a
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	FAM193B SHROOM1 GLI1 ATG16L2	1.83e-04	155	81	4	a4f2fffa8d0de760c556c3f8f1c91804eedbfa68
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CALCRL ECE1 TOX2 NOS3	1.83e-04	155	81	4	59035d792c26d870a8b097939e97fa47859ba68c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LRRC3B CALCRL TOX2 NOS3	1.93e-04	157	81	4	275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-C1ql2-Excitatory_Neuron.Slc17a7.C1ql2-Penk_(Dentate_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DNASE2B ETV2 IZUMO1R	1.97e-04	62	81	3	385e7de8b6d81052ee7dfc0958c7b3d924f73130
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SEMA3B GRIK2 IGLL1 FZD2	2.07e-04	160	81	4	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	facs-Skin-nan-24m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI1 CSPG4 FZD2 PALLD	2.28e-04	164	81	4	7a65c7a6dbe5fb9067f83efafbb7ec8206d79325
ToppCell	wk_20-22-Hematologic-Myeloid-HSC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FOXR1 SLC5A10 CSF3R IGLL1	2.28e-04	164	81	4	a35a0725b8bfe3cad5b85484217fd8a02bdee827
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 CALCRL ECE1 NOS3	2.38e-04	166	81	4	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	RNF112 LRCOL1 CALCRL NOS3	2.38e-04	166	81	4	5ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLPP5 IGLL1 TOX2 NUDT13	2.38e-04	166	81	4	a1009d25c5a500f470e8edb04097ac47d4d72f3c
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|356C / Donor, Lineage, Cell class and subclass (all cells)	RNF112 LRCOL1 CALCRL NOS3	2.38e-04	166	81	4	6bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLPP5 IGLL1 TOX2 NUDT13	2.38e-04	166	81	4	5a6e3364d223829f66e8da7f3560d95fd8bb9b11
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CALCRL ECE1 TOX2 NOS3	2.38e-04	166	81	4	8e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFNA1 CALCRL ECE1 NOS3	2.38e-04	166	81	4	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLPP5 IGLL1 TOX2 NUDT13	2.38e-04	166	81	4	e25bcbb5b3ba453a6e2572637f2521a32223a3ad
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 CALCRL ECE1 NOS3	2.55e-04	169	81	4	58136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 CALCRL ECE1 NOS3	2.55e-04	169	81	4	04c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell	facs-Marrow-T_cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN6 EFNA5 CHDH NEIL3	2.55e-04	169	81	4	2a35846b0e0be0a19a5a04a86cbd72ce65257c8a
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 CALCRL ECE1 NOS3	2.61e-04	170	81	4	af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 FOXR1 EFNA5 CHDH	2.67e-04	171	81	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM1 CALCRL TOX2 NOS3	2.67e-04	171	81	4	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	lymphoid-B_cell-pro-B\|B_cell / Lineage, cell class and subclass	P4HA2 COBL IGLL1 PALLD	2.73e-04	172	81	4	da1e2e54f442f5c2032c857c4812e9060f2053cd
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-non-classical_monocyte\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSF3R CRISP3 CALCRL PALLD	2.73e-04	172	81	4	968d18ab8c3cdeb7936a2aa721a7f41525763863
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB4 CALCRL ECE1 NOS3	2.73e-04	172	81	4	9a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	EPHB4 EFNA5 LRCOL1 CALCRL	2.79e-04	173	81	4	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB4 EFNA5 LRCOL1 CALCRL	2.79e-04	173	81	4	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	droplet-Heart-4Chambers-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 FOXR1 ECE1 NOS3	2.79e-04	173	81	4	9a04271c51fae34f547db3206f9ff5857686e45c
ToppCell	AT1_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	P4HA2 SEMA3B COIL PALLD	2.79e-04	173	81	4	b29816427428c7053017477f59b828bf1357f3b2
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors\|lymph-node_spleen / Manually curated celltypes from each tissue	KLF1 ZNF804B CRISP3 IGLL1	2.85e-04	174	81	4	6d9bdf4d28ff8ebb66ffd1ccdd6a4fe9440a83f3
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	EPHB4 CALCRL ECE1 NOS3	2.85e-04	174	81	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP10 CSF3R KLF1 GRINA	2.98e-04	176	81	4	fc51e4dcad5456c229d76fdcb9a80c4c79eacf3f
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC3B CALCRL TOX2 NOS3	2.98e-04	176	81	4	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 P4HA2 SLC5A10 ZNF804B	2.98e-04	176	81	4	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 ECE1 TOX2 NOS3	2.98e-04	176	81	4	1df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCell	droplet-Pancreas-Exocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 SHROOM1 CHDH FZD2	3.04e-04	177	81	4	a5b54792ef948a1e1de66301a60e051250189f59
Computational	Genes in the cancer module 27.	EPHB2 CSF3R LRP1 GRIK2 IGLL1 CALCRL FZD2 PTH2R	1.80e-04	355	49	8	MODULE_27
Disease	irritable bowel syndrome (implicated_via_orthology)	EPHB2 NOS3	6.86e-05	5	78	2	DOID:9778 (implicated_via_orthology)
Disease	limb ischemia (is_implicated_in)	ETV2 NOS3	1.03e-04	6	78	2	DOID:0050852 (is_implicated_in)
Disease	Essential hypertension	ECE1 NOS3	3.06e-04	10	78	2	cv:C0085580
Disease	Essential hypertension, genetic	ECE1 NOS3	3.06e-04	10	78	2	cv:CN305331
Disease	HYPERTENSION, ESSENTIAL	ECE1 NOS3	3.06e-04	10	78	2	145500
Disease	Essential Hypertension	ECE1 NOS3	4.48e-04	12	78	2	C0085580
Disease	Mammary Carcinoma, Human	EPHB4 MST1 EFNA1 LRRC3B GRIK2 ADAR NOS3	4.82e-04	525	78	7	C4704874
Disease	Mammary Neoplasms, Human	EPHB4 MST1 EFNA1 LRRC3B GRIK2 ADAR NOS3	4.82e-04	525	78	7	C1257931
Disease	Mammary Neoplasms	EPHB4 MST1 EFNA1 LRRC3B GRIK2 ADAR NOS3	4.93e-04	527	78	7	C1458155
Disease	Malignant neoplasm of breast	EPHB4 MST1 TRIML1 EFNA1 NF1 LRRC3B GLI1 GRIK2 ADAR NOS3	5.22e-04	1074	78	10	C0006142
Disease	Breast Carcinoma	EPHB4 MST1 EFNA1 LRRC3B GRIK2 ADAR NOS3	5.57e-04	538	78	7	C0678222
Disease	essential hypertension (is_implicated_in)	ECE1 NOS3	1.03e-03	18	78	2	DOID:10825 (is_implicated_in)
Disease	acute myeloid leukemia (is_implicated_in)	NF1 CSF3R NOS3	1.45e-03	84	78	3	DOID:9119 (is_implicated_in)
Disease	vasculitis	P4HA2 GAK	1.83e-03	24	78	2	EFO_0006803
Disease	leiomyoma (is_marker_for)	FZD2 NOS3	2.49e-03	28	78	2	DOID:127 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLSRHWGGQADFRCA	BRAT1	526	Q6PJG6
NDQKIRFWDSRGPHC	ATG16L2	481	Q8NAA4
FEAACPQRPSHLWKN	CSPG4	1696	Q6UVK1
FRMRQCGGQRSPWHA	DENND6B	96	Q8NEG7
QRQGARGWDYAHCLP	CHDH	151	Q8NE62
GRAVHQCDRGWAPVF	NUBP2	66	Q9Y5Y2
REWRAKVQGTVHCFP	RANBP10	231	Q6VN20
WRKPNGDFCSSHQEC	LRCOL1	116	A6NCL2
PLHWAAFKNNAECVR	ASB8	121	Q9H765
RQEKRPLCAQGDWHS	ELOA2	231	Q8IYF1
CCGDFRRKHPWNLVA	GRINA	216	Q7Z429
QGHRNCGEDWFRPKL	MAD2L1BP	216	Q15013
WADLSFPFCNHGKRS	NEIL3	546	Q8TAT5
CDVQRAPGQAHWLRT	EPHB4	61	P54760
RNSGRCLQKWFEPAQ	IZUMO1R	201	A6ND01
DQFQCKSGHCIPLRW	LRP1	3616	Q07954
ACFHGPNFRSKSWAL	KIAA1109	4666	Q2LD37
LWNPRHCIQDASKGS	MTNR1B	326	P49286
DCWQKDRNHRPKFGQ	EPHB2	861	P29323
TLDWRLGHKQACAQP	PDCD2	161	Q16342
NKFGFQWPERLRCEH	FZD2	126	Q14332
RPSNFRDCGQWFRHL	LRRC31	491	Q6UY01
WANQRCSSPKGSARN	COIL	211	P38432
HWGGCSRELRPFKAQ	GLI1	271	P08151
LKARARIANNPWHCD	LRRC3B	136	Q96PB8
FRSHNGKSREPWNPC	DEFB116	26	Q30KQ4
VERKSFNPWGLQCHQ	IP6K3	166	Q96PC2
RWHDAHQFCSRSGQP	NUDT13	161	Q86X67
VFGAKQAWRNAPRCV	NOS3	171	P29474
KWFHERGQEFLRPCG	P4HA2	516	O15460
RVRWFCEGKELHNTP	PALLD	301	Q8WX93
ARAGEQRCWHQPCFA	PRICKLE4	101	Q2TBC4
GEVSDAPQRKQFCHW	CCN6	36	O95389
RPSRFHNRVSECGWA	GAK	461	O14976
RCWPRGFQSKHNSVT	IGLL1	81	P15814
WARKRQAAHTCAHPG	KLF1	271	Q13351
KNRWTCIGDLNRSPH	DNASE2B	316	Q8WZ79
ARGEARKHWSDCLQQ	DOC2A	361	Q14183
WANQCNYRHSNPKDR	CRISP3	76	P54108
QAKVGGRWFPAVCAH	ADAR	761	P55265
GRWFPAVCAHSKKQG	ADAR	766	P55265
ASQGFKRWECNRPHA	EFNA3	101	P52797
DQVRWQCNRPSAKHG	EFNA1	86	P20827
HPNKRHFSNADRGDW	CHD2	1626	O14647
CHRERKGWEEGPSQN	FAM193B	86	Q96PV7
WRCNSVEKHLGRPSE	COBL	771	O75128
GWKNTVRHNLCFRDS	FOXR1	216	Q6PIV2
ANAHRGPAKVDCWNE	CFAP97D1	86	B2RV13
CELRHKPQRGEASWA	CSF3R	266	Q99062
DHTSKGFKRWECNRP	EFNA5	91	P52803
QVNFHSPRSGQRCWA	ECE1	46	P42892
RKGVQCQRWSAETPH	MST1	386	P26927
QCNRHKPWRFGTRFM	GRIK2	346	Q13002
RWTGNSREFQLCDPK	ETV2	261	O00321
NSADKHRNDCPNWIT	SCAF11	1011	Q99590
VTKICDQDGNWFRHP	CALCRL	101	Q16602
RAGCSHLEKQWIPSQ	CPHXL	136	A0A1W2PPM1
AQCAKRDWNRLKNHP	FAN1	631	Q9Y2M0
NFGRCPKWSGRQAFV	PPP4R1	831	Q8TF05
RGPLANQQRKWCFSE	SHROOM1	211	Q2M3G4
HCSKAPWQDLARQNR	C15orf61	91	A6NNL5
AEFHCPKCRHNFRGW	SHFL	151	Q9NUL5
PKCRHNFRGWAQMGS	SHFL	156	Q9NUL5
SRAHWQGCRKAVLND	ZNF804B	606	A4D1E1
CGKAFRWPSNLTRHK	ZNF735	246	P0CB33
APQHAKSRCQGYWNE	RNF112	396	Q9ULX5
TPQKHAFWARVCGFN	SLC5A10	566	A0PJK1
WDGVACTRFQPSAKR	SEMA3B	536	Q13214
WPAKEENSCSHGRIQ	SPATA8	61	Q6RVD6
KVWFRRGVNSHNPCG	TECPR1	311	Q7Z6L1
GAQRRHGWNPKDCSE	SPSB2	41	Q99619
PWGSCHFLEKARIAQ	SPPL2A	91	Q8TCT8
LHCFTPQGRGKSWRF	PLPP5	171	Q8NEB5
PWLSNLVRFCKHNDD	NF1	1951	P21359
WPRKFFHRTCKCTGN	DCT	86	P40126
KGVAFRHCNPNGTWD	PTH2R	96	P49190
SVCGKTFRQAPHWKR	ZNF770	656	Q6IQ21
CWRTLEGPHFQSNER	TRIML1	56	Q8N9V2
RHWCIAGVFPQKFDG	TOX2	31	Q96NM4
WQGHIFALNRCEKPI	RPTN	221	Q6XPR3
RHCFPWCRGSSKSNV	POTEG	66	Q6S5H5
RHQWTHSGERPFNCK	ZNF337	561	Q9Y3M9
CGKAFRWPSNLTRHK	ZNF722	246	A0A1W2PQL4
QNWHLPERFKACNHR	LRRIQ3	166	A6PVS8