Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TPCN2 RYR1 ITPR2

7.11e-0518913GO:0015278
GeneOntologyMolecularFunctionlow-affinity IgG receptor activity

FCGR3A FCGR3B

1.23e-044912GO:0019772
GeneOntologyMolecularFunctionIgE receptor activity

FCGR3A FCGR3B

3.04e-046912GO:0019767
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TPCN2 RYR1 ITPR2

3.75e-0431913GO:0099604
GeneOntologyMolecularFunctionIgE binding

FCGR3A FCGR3B

4.25e-047912GO:0019863
GeneOntologyMolecularFunctionIgG receptor activity

FCGR3A FCGR3B

4.25e-047912GO:0019770
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TPCN2 RYR1 ITPR2

4.52e-0433913GO:0005217
GeneOntologyBiologicalProcessprotein-containing complex localization

RELN NRXN3 FCGR3A FCGR3B ATM SNAP25 TERF1 TSPAN9 PCM1

3.51e-06278909GO:0031503
GeneOntologyBiologicalProcessperforin production

FCGR3A FCGR3B

1.88e-052902GO:0035944
GeneOntologyBiologicalProcessantibody-dependent cellular cytotoxicity

FCGR3A FCGR3B IGHG4

2.23e-0513903GO:0001788
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance

PARP1 ATM TERF1 SMG6

3.34e-0542904GO:0032205
GeneOntologyBiologicalProcesstype IIa hypersensitivity

FCGR3A FCGR3B IGHG4

3.52e-0515903GO:0001794
GeneOntologyBiologicalProcesstype II hypersensitivity

FCGR3A FCGR3B IGHG4

3.52e-0515903GO:0002445
GeneOntologyBiologicalProcessembryo development

HINFP LATS1 KIDINS220 FOXL2 KIAA1217 TTLL4 KIF1B ENAH LAMA2 TSHZ1 CHD7 MSH2 ATM ECE1 THOC2 KIT YTHDF2 XAB2

4.12e-0514379018GO:0009790
GeneOntologyBiologicalProcessestablishment of RNA localization to telomere

ATM TERF1

5.63e-053902GO:0097694
GeneOntologyBiologicalProcessestablishment of protein-containing complex localization to telomere

ATM TERF1

5.63e-053902GO:0097695
GeneOntologyBiologicalProcessnegative regulation of DNA metabolic process

PARP1 ENPP7 MSH2 ATM TERF1 SMG6

6.05e-05155906GO:0051053
GeneOntologyBiologicalProcesshypersensitivity

FCGR3A FCGR3B IGHG4

1.72e-0425903GO:0002524
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

HINFP LATS1 KIDINS220 KIAA1217 TTLL4 KIF1B ENAH CHD7 MSH2 ATM ECE1 THOC2 XAB2

1.90e-049299013GO:0009792
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomere lengthening

PARP1 ATM TERF1 SMG6

2.36e-0469904GO:1904356
GeneOntologyBiologicalProcesspositive regulation of bone resorption

FCGR3A FCGR3B CA2

2.43e-0428903GO:0045780
GeneOntologyCellularComponentchromosome, telomeric region

PARP1 POLR2B MSH2 ATM THOC2 TERF1 SMG6

1.10e-05176907GO:0000781
GeneOntologyCellularComponentFc-gamma receptor III complex

FCGR3A FCGR3B

1.09e-044902GO:0033001
DomainPRT_C

MCTP1 MCTP2

2.19e-052882PF08372
DomainPRibTrfase_C

MCTP1 MCTP2

2.19e-052882IPR013583
DomainYTH

YTHDF1 YTHDF2

2.17e-045882PF04146
DomainYTH_domain

YTHDF1 YTHDF2

2.17e-045882IPR007275
DomainYTH

YTHDF1 YTHDF2

2.17e-045882PS50882
DomainRIH_assoc-dom

RYR1 ITPR2

3.25e-046882IPR013662
DomainIns145_P3_rec

RYR1 ITPR2

3.25e-046882PF08709
DomainRIH_assoc

RYR1 ITPR2

3.25e-046882PF08454
DomainRIH_dom

RYR1 ITPR2

3.25e-046882IPR000699
DomainIns145_P3_rcpt

RYR1 ITPR2

3.25e-046882IPR014821
DomainRyanodine_recept-rel

RYR1 ITPR2

3.25e-046882IPR015925
Domain-

RYR1 ITPR2

3.25e-0468821.25.10.30
DomainRYDR_ITPR

RYR1 ITPR2

3.25e-046882PF01365
DomainPeptidase_M13_C

ECE1 ECE2

4.54e-047882IPR018497
DomainPeptidase_M13

ECE1 ECE2

4.54e-047882IPR000718
DomainPeptidase_M13_N

ECE1 ECE2

4.54e-047882PF05649
DomainPeptidase_M13_N

ECE1 ECE2

4.54e-047882IPR008753
DomainPeptidase_M13

ECE1 ECE2

4.54e-047882PF01431
DomainEF-hand_8

EFCAB6 CAPN3 RYR1

5.44e-0434883PF13833
DomainDNA/RNA_helicase_DEAH_CS

DHX57 CHD7 DHX8

5.93e-0435883IPR002464
DomainDEAH_ATP_HELICASE

DHX57 CHD7 DHX8

7.57e-0438883PS00690
DomainMIR

RYR1 ITPR2

9.64e-0410882PF02815
DomainMIR_motif

RYR1 ITPR2

9.64e-0410882IPR016093
DomainMIR

RYR1 ITPR2

9.64e-0410882PS50919
DomainMIR

RYR1 ITPR2

9.64e-0410882SM00472
DomainEGF_extracell

RELN TNN TENM1

2.85e-0360883IPR013111
DomainEGF_2

RELN TNN TENM1

2.85e-0360883PF07974
DomainDUF1605

DHX57 DHX8

2.85e-0317882IPR011709
DomainOB_NTP_bind

DHX57 DHX8

2.85e-0317882PF07717
DomainHA2

DHX57 DHX8

3.20e-0318882SM00847
DomainHA2

DHX57 DHX8

3.20e-0318882PF04408
DomainHelicase-assoc_dom

DHX57 DHX8

3.20e-0318882IPR007502
DomainFibrinogen_CS

TNN FGL1

3.56e-0319882IPR020837
DomainPDEase

PDE8A PDE11A

3.56e-0319882IPR023088
DomainPDEase_I

PDE8A PDE11A

4.35e-0321882PF00233
DomainPDEASE_I

PDE8A PDE11A

4.35e-0321882PS00126
DomainPDEase_CS

PDE8A PDE11A

4.35e-0321882IPR023174
Domain-

PDE8A PDE11A

4.77e-03228821.10.1300.10
DomainTPR-like_helical_dom

EEF2K GPSM1 XAB2 TTC6 SMG6

4.90e-03233885IPR011990
DomainEGF

RELN NRXN3 TNN TENM1 LAMA2

5.08e-03235885SM00181
DomainPDEase_catalytic_dom

PDE8A PDE11A

5.21e-0323882IPR002073
DomainHD/PDEase_dom

PDE8A PDE11A

5.66e-0324882IPR003607
DomainFibrinogen_a/b/g_C_2

TNN FGL1

5.66e-0324882IPR014715
Domain-

TNN FGL1

5.66e-03248824.10.530.10
DomainHDc

PDE8A PDE11A

5.66e-0324882SM00471
DomainWGR_domain

PARP1 LAMA2

5.66e-0324882IPR008893
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PARP1 FARSA RELN CSE1L KIDINS220 POLR2B SUGP1 DHX57 CHD7 RPL14 EIF3B ATM THOC2 TERF1 XAB2 DHX8

2.37e-081082921638697112
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

PARP1 FARSA CSE1L KIAA1217 PKP4 POLR2B ARPC1A OAS3 MSH2 RPL14 EIF3B THOC2 YTHDF2 XAB2 LRRFIP2 DHX8 ITPR2

3.00e-081257921736526897
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

PARP1 FARSA CSE1L POLR2B LTN1 DHX57 OAS3 PCMTD2 MSH2 RPL14 EIF3B ATM SNAP25 THOC2 YTHDF2 PCM1 LRRFIP2 ITPR2

3.68e-081440921830833792
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

YTHDF1 LATS1 PKP4 KIF1B ENAH GPSM1 PCM1 SMG6

1.24e-0721892833378226
Pubmed

Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining.

PARP1 ATM TERF1

1.78e-07592327806302
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 PARP1 FARSA CSE1L KIDINS220 ANAPC1 POLR2B ARPC1A ENAH MSH2 RPL14 EIF3B ATM THOC2 CA2 LRRFIP2 DHX8

1.80e-071425921730948266
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

HINFP PARP1 LTN1 DHX57 EEF2K RPL14 EIF3B DHX8

3.53e-0725092833536335
Pubmed

FAM188B enhances cell survival via interaction with USP7.

ANAPC1 POLR2B RPL14 EIF3B PCM1

8.46e-076592529795372
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

PARP1 FARSA LATS1 CSE1L PKP4 POLR2B KIF1B MSH2 HMGCS1 RPL14 EIF3B THOC2 MAP2K3 LRRFIP2 DHX8

9.43e-071247921527684187
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CSE1L ANAPC1 DHX57 CHD7 MSH2 RPL14 ATM THOC2 PCM1 XAB2 DHX8

1.28e-06653921122586326
Pubmed

FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.

FCGR3A FCGR3B IGHG4

1.49e-06992320974962
Pubmed

Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis.

FCGR3A FCGR3B KIT

2.91e-061192321248252
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

YTHDF1 PARP1 FARSA MYH11 CSE1L POLR2B RPL14 EIF3B YTHDF2 XAB2 DHX8

3.01e-06714921128302793
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

YTHDF1 PARP1 FARSA MYH11 CSE1L DHX57 OAS3 CHD7 RPL14 PLD1 THOC2 YTHDF2 PCM1 XAB2 LRRFIP2

3.03e-061371921536244648
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

YTHDF1 FARSA ANAPC1 TTLL4 POLR2B SUGP1 CHD7 YTHDF2 PCM1 DHX8 ITPR2

3.87e-06733921134672954
Pubmed

MCM8 interacts with DDX5 to promote R-loop resolution.

PARP1 FOXL2 ATM

5.03e-061392338858601
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PARP1 FARSA MYH11 CSE1L KIDINS220 KIAA1217 PKP4 KIF1B ARPC1A DHX57 RPL14 PCM1 CA2 LRRFIP2 ITPR2

5.08e-061431921537142655
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

FARSA CSE1L POLR2B DHX57 MSH2 RPL14 THOC2 TERF1 YTHDF2 LRRFIP2 DHX8

5.38e-06759921135915203
Pubmed

Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.

FCGR3A FCGR3B

6.92e-0629222521732
Pubmed

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.

PARP1 ATM

6.92e-06292217428792
Pubmed

Single-cell analyses identify dysfunctional CD16+ CD8 T cells in smokers.

FCGR3A FCGR3B

6.92e-06292233163982
Pubmed

Association study of copy number variants in FCGR3A and FCGR3B gene with risk of ankylosing spondylitis in a Chinese population.

FCGR3A FCGR3B

6.92e-06292226494566
Pubmed

Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice.

PARP1 ATM

6.92e-0629229934867
Pubmed

Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine.

MYH11 KIT

6.92e-0629229438424
Pubmed

N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

YTHDF1 YTHDF2

6.92e-06292226046440
Pubmed

Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis.

FCGR3A FCGR3B

6.92e-06292223917248
Pubmed

Evidence for gene recombination in FCGR3 gene variants.

FCGR3A FCGR3B

6.92e-06292219320901
Pubmed

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.

FCGR3A FCGR3B

6.92e-06292225966632
Pubmed

The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.

FCGR3A FCGR3B

6.92e-0629222967436
Pubmed

Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development.

FOXL2 KIT

6.92e-06292212810580
Pubmed

Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties.

MCTP1 MCTP2

6.92e-06292215528213
Pubmed

Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response.

PARP1 ATM

6.92e-06292215178448
Pubmed

Low copy numbers of FCGR3A and FCGR3B associated with Chinese patients with SLE and AASV.

FCGR3A FCGR3B

6.92e-06292228355982
Pubmed

The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.

FCGR3A FCGR3B

6.92e-0629227836402
Pubmed

Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells.

FCGR3A FCGR3B

6.92e-06292225816339
Pubmed

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development.

ECE1 ECE2

6.92e-06292210811845
Pubmed

Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome.

MSH2 LGR5

6.92e-06292225088490
Pubmed

Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.

MCTP1 MCTP2

6.92e-06292233826368
Pubmed

LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity.

LATS1 FOXL2

6.92e-06292220407010
Pubmed

The loss of the CD16 B73.1/Leu11c epitope occurring in some primary immunodeficiency diseases is not associated with the FcgammaRIIIa-48L/R/H polymorphism.

FCGR3A FCGR3B

6.92e-06292220664961
Pubmed

FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.

FCGR3A FCGR3B

6.92e-06292234108956
Pubmed

Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development.

PARP1 ATM

6.92e-06292211238919
Pubmed

Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies.

ECE1 ECE2

6.92e-06292228171705
Pubmed

The human natural killer cytotoxic cell line NK-92, once armed with a murine CD16 receptor, represents a convenient cellular tool for the screening of mouse mAbs according to their ADCC potential.

FCGR3A FCGR3B

6.92e-06292223770975
Pubmed

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.

YTHDF1 YTHDF2

6.92e-06292234408926
Pubmed

Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.

FCGR3A FCGR3B

6.92e-06292222290871
Pubmed

Fcγ receptor IIIb polymorphism and use of glucocorticoids at baseline are associated with infusion reactions to infliximab in patients with rheumatoid arthritis.

FCGR3A FCGR3B

6.92e-06292220980704
Pubmed

Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen.

FCGR3A FCGR3B

6.92e-06292211034564
Pubmed

The mechanism underlying redundant functions of the YTHDF proteins.

YTHDF1 YTHDF2

6.92e-06292236694229
Pubmed

Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene.

FCGR3A FCGR3B

6.92e-0629228940055
Pubmed

The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk.

ECE1 ECE2

6.92e-06292222693153
Pubmed

DNA Repair Gene Expression Levels as Indicators of Breast Cancer in the Breast Cancer Family Registry.

MSH2 ATM

6.92e-06292227466510
Pubmed

FCGR3A and FCGR3B copy number variations are risk factors for sarcoidosis.

FCGR3A FCGR3B

6.92e-06292227059607
Pubmed

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.

PARP1 ATM

6.92e-06292217459151
Pubmed

The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells.

MSH2 LGR5

6.92e-06292234003775
Pubmed

Association of FCGR3A and FCGR3B copy number variations with systemic lupus erythematosus and rheumatoid arthritis in Taiwanese patients.

FCGR3A FCGR3B

6.92e-06292225154742
Pubmed

Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome.

MSH2 LGR5

6.92e-06292234543445
Pubmed

A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.

FCGR3A FCGR3B

6.92e-0629222525780
Pubmed

Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy.

PARP1 TERF1

6.92e-06292220137830
Pubmed

Molecular and functional evidence for early divergence of an endothelin-like system during metazoan evolution: analysis of the Cnidarian, hydra.

ECE1 ECE2

6.92e-06292211290299
Pubmed

FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma.

FCGR3A FCGR3B

6.92e-06292212445195
Pubmed

Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.

FCGR3A FCGR3B

6.92e-0629222526846
Pubmed

B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions.

FCGR3A FCGR3B

6.92e-06292218292508
Pubmed

Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.

ECE1 ECE2

6.92e-06292227644077
Pubmed

Mutations in LAMA2 and CAPN3 genes associated with genetic and phenotypic heterogeneities within a single consanguineous family involving both congenital and progressive muscular dystrophies.

CAPN3 LAMA2

6.92e-06292220477750
Pubmed

ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.

PARP1 ATM

6.92e-06292220124459
Pubmed

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.

CHD7 SNAP25 KIT

9.78e-061692310932191
Pubmed

Defining the membrane proteome of NK cells.

PARP1 FARSA CSE1L KIDINS220 MSH2 RPL14 PLD1 ECE1 MAP2K3 MCTP2 PCM1 XAB2 ITPR2

1.24e-051168921319946888
Pubmed

PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2.

PARP1 FARSA CSE1L ENAH RPL14 YTHDF2 CA2

1.25e-0529092732929329
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

KIAA1217 PKP4 TTLL4 ENAH PCMTD2 CHD7 HMGCS1 TSPAN9 SMG6

1.28e-0553692915840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

KIAA1217 PKP4 TTLL4 ENAH PCMTD2 CHD7 HMGCS1 TSPAN9 SMG6

1.32e-0553892910512203
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

PARP1 CSE1L POLR2B ARPC1A MSH2 RPL14 EIF3B THOC2 PCM1 XAB2 DHX8 ITPR2

1.66e-051024921224711643
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

CSE1L ANAPC1 POLR2B ENAH LTN1 SUGP1 HMGCS1 XAB2 DHX8

1.81e-0556092935241646
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

YTHDF1 KIAA1217 TTLL4 POLR2B ARHGAP12 ARPC1A ENAH TBC1D2B SUGP1 EEF2K GPSM1 YTHDF2

1.90e-051038921226673895
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

YTHDF1 LTN1 MRPL13 DHX57 RPL14 THOC2 YTHDF2 XAB2 LRRFIP2 DHX8

1.96e-05713921029802200
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DNHD1 PARP1 KIDINS220 MSH2 THOC2 RYR1

1.98e-0520892633230847
Pubmed

KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.

MYH11 KIT

2.07e-05392222160378
Pubmed

Fc gamma receptor genes as risk markers for localized aggressive periodontitis in African-Americans.

FCGR3A FCGR3B

2.07e-05392212027254
Pubmed

Monitoring of post-transplant CBFB-MYH11 as minimal residual disease, rather than KIT mutations, can predict relapse after allogeneic haematopoietic cell transplantation in adults with inv(16) acute myeloid leukaemia.

MYH11 KIT

2.07e-05392227650511
Pubmed

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.

YTHDF1 YTHDF2

2.07e-05392235508130
Pubmed

Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission.

RELN SNAP25

2.07e-05392224210904
Pubmed

Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

FCGR3A FCGR3B

2.07e-0539221825220
Pubmed

Polymorphism of Fc gamma RIIa may affect the efficacy of gamma-globulin therapy in Kawasaki disease.

FCGR3A FCGR3B

2.07e-05392216133986
Pubmed

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11.

MYH11 CHD7

2.07e-05392229018080
Pubmed

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.

PARP1 TXK

2.07e-05392217177976
Pubmed

A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.

YTHDF1 YTHDF2

2.07e-05392232492408
Pubmed

Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.

FCGR3A FCGR3B

2.07e-05392228427365
Pubmed

Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains.

FCGR3A FCGR3B

2.07e-05392216709862
Pubmed

Patterns of low-affinity immunoglobulin receptor polymorphisms in stroke and homozygous sickle cell disease.

FCGR3A FCGR3B

2.07e-05392211835346
Pubmed

FcgammaRIIa, IIIa and IIIb gene polymorphisms in Behçet's disease: do they have any clinical implications?

FCGR3A FCGR3B

2.07e-05392219026120
Pubmed

An immunohistochemical panel consisting of EZH2, C-KIT, and CD205 is useful for distinguishing thymic squamous cell carcinoma from type B3 thymoma.

LY75 KIT

2.07e-05392229487009
Pubmed

Immunoglobulin G fc-receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms related to disease severity in rheumatoid arthritis.

FCGR3A FCGR3B

2.07e-05392212064825
Pubmed

inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations.

MYH11 KIT

2.07e-05392223160462
Pubmed

FcgammaRIIA, FcgammaRIIIA and FcgammaRIIIB polymorphisms in Spanish patients with systemic lupus erythematosus.

FCGR3A FCGR3B

2.07e-05392212121275
Pubmed

Infectious complications after chemotherapy and stem cell transplantation in multiple myeloma: implications of Fc gamma receptor and myeloperoxidase promoter polymorphisms.

FCGR3A FCGR3B

2.07e-05392218452102
Pubmed

Fcgamma receptor polymorphisms in relation to periodontitis.

FCGR3A FCGR3B

2.07e-05392212834496
Pubmed

Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases.

FCGR3A FCGR3B

2.07e-05392216550341
Pubmed

Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients.

FCGR3A FCGR3B

2.07e-05392214597109
Pubmed

Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells.

FOXL2 KIT

2.07e-05392217728319
Pubmed

Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis.

FCGR3A FCGR3B

2.07e-05392222167032
GeneFamilyMultiple C2 and transmembrane domain containing

MCTP1 MCTP2

1.27e-052652826
CoexpressionGSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_DN

DPYD PDE8A BEND5 ENAH PCMTD2 MCTP2 ZNF404

6.64e-06199927M9236
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

DENND5B NRXN3 MSH2 SNAP25 LGR5 SMG6 ITPR2

1.20e-07186927de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

DENND5B NRXN3 MSH2 SNAP25 LGR5 SMG6 ITPR2

1.20e-071869270b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCelldroplet-Kidney-KIDNEY-1m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGR3A FCGR3B TBC1D2B OAS3 SLAMF7 GPSM1

1.50e-06171926d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 MCTP1 KIT ECE2 CA2

2.76e-0619092656cc761e50fddfb5366391518b4d8e16589b6b42
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 MCTP1 KIT ECE2 CA2

2.76e-0619092625d4b591f75c26e404a34c42f1742d580af6598d
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRXN3 KIAA1217 PKP4 ECE1 KIT TSPAN9

3.12e-0619492668004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCellhealthy_donor-Lymphocytic-ILC-NK_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

FCGR3A FCGR3B ATM SLAMF7 MCTP2 TXK

3.51e-06198926d7053a898e04478c577381085f615edaad3cdc5b
ToppCellhealthy_donor-Lymphocytic-ILC|healthy_donor / Disease condition, Lineage, Cell class and subclass

FCGR3A FCGR3B ATM SLAMF7 MCTP2 TXK

3.51e-06198926aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TENM1 ATM MCTP2 PCM1 SMG6 TXK

3.61e-06199926f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellMacroglial-Oligodendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD NRXN3 PDE8A CAPN3 PLD1 CA2

3.71e-062009264dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCellMacroglial-Oligodendrocytes-OPALIN--|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD NRXN3 PDE8A CAPN3 PLD1 CA2

3.71e-0620092626b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCellControl-Control-Lymphocyte-T/NK-NK|Control / Disease, condition lineage and cell class

FCGR3A FCGR3B ATM SLAMF7 MCTP2 TXK

3.71e-06200926c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCellMacroglial-Oligodendrocytes-OPALIN---|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD NRXN3 PDE8A CAPN3 PLD1 CA2

3.71e-062009261314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCellMacroglial-Oligodendrocytes-OPALIN-|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD NRXN3 PDE8A CAPN3 PLD1 CA2

3.71e-062009268b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCellMacroglial-Oligodendrocytes-OPALIN----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD NRXN3 PDE8A CAPN3 PLD1 CA2

3.71e-06200926272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCellMacroglial-Oligodendrocytes-OPALIN|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD NRXN3 PDE8A CAPN3 PLD1 CA2

3.71e-062009265f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EFCAB6 TENM1 KIT MCTP2 PDE11A

4.48e-061179250602bbad908cb28c5093b74d717da5f2af577943
ToppCellCOVID-19-kidney-Mito-rich_Int|kidney / Disease (COVID-19 only), tissue and cell type

RELN MYH11 NRXN3 AKR1D1 LAMA2

7.22e-0612992557b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCellpdx-Tumor_cells-T9|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

IQCA1L POLR2B ENAH EIF3B MAP2K3

1.23e-051449250b94d978262a826c9254145aa98c6c30240243f9
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

MYH11 NRXN3 TNN LAMA2 TSHZ1

1.76e-051559251882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIDINS220 FCGR3A FAM3B GPSM1 RYR1

2.11e-051619253f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KIDINS220 EFCAB6 TBC1D2B KIT PDE11A

2.24e-05163925bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell390C-Lymphocytic-NK_cells-NK_cell_C|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FCGR3A FCGR3B ATM MCTP2 TXK

2.74e-0517092581341bf4fe090af70b2091b6b2579ed08d76e22d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYH11 NRXN3 SNAP25 PLD1 CPED1

2.74e-0517092599dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYH11 NRXN3 SNAP25 PLD1 CPED1

2.74e-051709253a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYH11 NRXN3 SNAP25 PLD1 CPED1

2.74e-05170925cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FOXL2 FCGR3A FCGR3B KIT MCTP2

2.98e-051739259eaec30f9a3655b53ece1b66848201a7f85bbdf5
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FCGR3A ATM SLAMF7 MCTP2 TXK

2.98e-051739255d3c917e4d0de3158550a8ab2006ddfa87159ffa
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN3 TMEM116 LAMA2 KIT ITPR2

3.14e-0517592577c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellpdx-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RELN FAM3B SNAP25 LGR5 TTC6

3.23e-051769251e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCellControl-B_cells|Control / group, cell type (main and fine annotations)

KLHL6 DENND5B IGHG4 ATM SLAMF7

3.23e-051769259125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH11 TTLL4 ARHGAP12 AKR1D1 SNAP25

3.32e-051779258abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MCTP1 FCGR3A FCGR3B KIT MCTP2

3.41e-05178925af9bcee71fb44a6342d4b92bba5b8ddfeeaa24b2
ToppCell368C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MYH11 TPCN2 MCTP1 EEF2K XAB2

3.60e-05180925eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell368C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MYH11 TPCN2 MCTP1 EEF2K XAB2

3.60e-05180925ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN NRXN3 ARHGAP12 KIT ECE2

3.79e-05182925f2a1784ffcba9b27132e0db21e574cbd8a0a6418
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAM MCTP1 FCGR3B ECE1 MCTP2

3.79e-05182925dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MYH11 FCGR3A ATM SLAMF7 TXK

3.79e-05182925c6172aca2475bf0948a78e39f0dae6388504a915
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYH11 LAMA2 CPED1 MCTP2 CA2

3.89e-051839258a799807fbf24456a9811e0c64068187940a2f71
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

NRXN3 TMEM116 LAMA2 KIT ITPR2

3.89e-051839255c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KLHL6 DENND5B IGHG4 ATM SLAMF7

4.10e-051859253b77bc49cd3740acc025e162a36282ac09e12198
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DENND5B RELN SNAP25 LGR5 ITPR2

4.10e-051859251d874608aa2062024323512f68889219471b2f00
ToppCellCOVID-19_Moderate-NK_activated|World / disease group, cell group and cell class

MGAM FCGR3A OAS3 MCTP2 TXK

4.21e-05186925ff8f32f69516bf785224fa12f8139a95359b0279
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAM FCGR3A ATM MCTP2 TXK

4.21e-05186925fc0b488c201a32d829047b58460297df2818b45d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN NRXN3 MCTP1 CHD7 SNAP25

4.21e-05186925d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCellCF|World / Disease state, Lineage and Cell class

MGAM FCGR3B SLAMF7 ECE1 MCTP2

4.31e-05187925eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE8A CAPN3 CHD7 PLD1 CA2

4.31e-05187925b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN NRXN3 MCTP1 CHD7 SNAP25

4.31e-051879251b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAM FCGR3A ATM MCTP2 TXK

4.31e-051879256981b856187a2e689260ecb7d0a1193a374ee9b9
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC17A5 LATS1 BEND5 TTLL4 CPED1

4.42e-051889256468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC17A5 LATS1 BEND5 TTLL4 CPED1

4.42e-051889257a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC17A5 LATS1 BEND5 TTLL4 CPED1

4.42e-051889259cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellFetal_29-31_weeks-Immune-natural_killer_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FCGR3A ATM SLAMF7 MCTP2 TXK

4.42e-051889251082861eb9e00409caa06d8b2a7b8e7f5fac94c9
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 TENM1 CPED1 TSPAN9 ECE2

4.42e-051889258de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE8A CAPN3 CHD7 PLD1 CA2

4.54e-0518992570eea8c94fa56bb15bee8065de47acea156794e9
ToppCellcellseq-Immune-Hematopoietic-Granulocytic-Neutrophil|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MGAM FCGR3B KIF1B TENM1 MCTP2

4.54e-05189925fedab592be1d6520325b8c1b659b0a4dc3f4fe4d
ToppCell10x_3'_v3-spleen_(10x_3'_v3)|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAM FCGR3A FCGR3B SLAMF7 MCTP2

4.54e-051899250fe8901e10c619c93b7788792da1706a32102c6e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 TENM1 CPED1 TSPAN9 ECE2

4.65e-05190925d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MCTP1 FCGR3A FGL1 SLAMF7 RYR1

4.65e-05190925e5625feb21915d4545cfad2659745ef180efcb1f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.65e-051909253b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 ARHGAP12 TENM1 CPED1 TSPAN9

4.65e-051909253f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellCOVID-19-kidney-NK|kidney / Disease (COVID-19 only), tissue and cell type

FCGR3A ATM SLAMF7 MCTP2 TXK

4.65e-05190925e3ca3c9fb9e27670a5dd128dd6564ff98a57159e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 TENM1 CPED1 TSPAN9 ECE2

4.65e-05190925305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.65e-05190925be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.65e-05190925dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN PKP4 SNAP25 ECE1 GPSM1

4.77e-051919253387b95a3f2445c672d407922fdce3a91eabaef8
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KLHL6 MCTP1 FCGR3A FGL1 SLAMF7

4.77e-05191925367d300da3925e0a329271b5f19483a37265a878
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYH11 NRXN3 LAMA2 ECE1 CPED1

4.77e-0519192504c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TENM1 ATM SLAMF7 MCTP2 TXK

4.77e-051919259b8b64a36e27a2523b8730c7922fd7ad865a021e
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TENM1 ATM SLAMF7 MCTP2 TXK

4.77e-051919256345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCellB_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

KLHL6 DENND5B IGHG4 CHD7 SLAMF7

4.77e-0519192572e3191990973440e4f91427208df360f73e4f41
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.89e-05192925f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.89e-0519292563d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.89e-05192925342842378c20267c5044bdd622515e8b9f895623
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN CHD7 KIT MCTP2 ECE2

4.89e-051929256a252e298f8a454623fa9c1c893a7a45a886d694
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.89e-05192925bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

4.89e-05192925690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

5.01e-05193925294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCellNS-critical-d_07-13-Myeloid-Monocyte-derived_Macrophage|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FCGR3A OAS3 SLAMF7 CPED1 ITPR2

5.01e-051939250dd83b21e164147abfd511a927615c40a28781a2
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MGAM MCTP1 FCGR3A FCGR3B SLAMF7

5.01e-05193925b044fca95f519ff2ceb378afe40a95911931a29e
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

DENND5B NRXN3 MSH2 TSPAN9 ITPR2

5.01e-05193925503a979328c68b096680b71359a26f02fafdff35
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

5.01e-051939253d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 ARHGAP12 TENM1 CPED1 TSPAN9

5.01e-05193925c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

TENM1 ATM SLAMF7 MCTP2 TXK

5.01e-051939251cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCellCOVID-19-lung-NK/NKT|COVID-19 / Disease (COVID-19 only), tissue and cell type

FCGR3A ATM SLAMF7 MCTP2 TXK

5.01e-05193925c24b44fcc92fff42ebba6f1aff91c7aaea179e56
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

5.14e-0519492552aebb0b563e2c2058e7f0554ae870e47692b163
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

5.14e-051949256ac759828c41ffa974ee82842162caa959351dd1
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_NK-natural_killer_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FCGR3A ATM SLAMF7 MCTP2 TXK

5.14e-05194925a3a81638b55cb5fc08fe83c8b88f68d49b87e6cb
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRXN3 KIAA1217 ECE1 KIT TSPAN9

5.14e-0519492571ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-neutrophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MGAM FCGR3A FCGR3B HPR CAPN3

5.14e-05194925e2d0dfb92356fa7ad7008aa8ac4198e2ac5d2495
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL6 PARP1 SLAMF7 LGR5 PCM1

5.14e-051949258ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MCTP1 KIAA1217 PKP4 ECE1 KIT

5.14e-051949250b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

5.14e-051949255d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCellILEUM-inflamed-(6)_ILC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FCGR3A KIT MCTP2 CA2 TXK

5.14e-051949254d51d49366c34ff1241770b4acc0167a43b3155a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

5.14e-05194925bd06e2b8d8c06cddf2e4f58849b86e09013acae1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN3 KIAA1217 ENAH LAMA2 CPED1

5.14e-0519492590efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN3 KIAA1217 ENAH LAMA2 CPED1

5.14e-05194925df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_NK-natural_killer_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FCGR3A ATM SLAMF7 MCTP2 TXK

5.14e-051949250abca32c3547a45cebab0bd69c1f7a0002deaa80
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FCGR3A ATM SLAMF7 MCTP2 TXK

5.26e-05195925609732e83ab7fc3ba7dace66f5a17e46557fd6d1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYH11 KIT ECE2 CA2

5.26e-0519592598ca9f3aa36211dde1e6f7f3817b9418c95e583e
DrugBacitracin [1405-87-4]; Down 200; 2.8uM; HL60; HT_HG-U133A

LATS1 CSE1L BEND5 TTLL4 KIF1B SUGP1 LAMA2 PLD1 PCM1 XAB2

6.87e-0919891103109_DN
DrugFluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A

DENND5B SUGP1 ATM SNAP25 MAP2K3 KIT PCM1 SMG6

1.07e-061939184129_DN
Drugmagnesium hydroxide

MGAM FCGR3A FCGR3B MRPL13 MSH2 THOC2

4.51e-06107916CID000014791
Drugcortisone 21-acetate

FOXL2 FCGR3A FCGR3B CAPN3 AKR1D1

9.00e-0670915CID000002863
DrugDicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; PC3; HT_HG-U133A

SLC17A5 NRXN3 SNAP25 FGL1 MAP2K3 CPED1 ITPR2

1.02e-051879174581_UP
DrugDiflorasone Diacetate [33564-31-7]; Up 200; 8uM; MCF7; HT_HG-U133A

DENND5B MCTP1 HMGCS1 SNAP25 FGL1 SLAMF7 TSPAN9

1.48e-051989174158_UP
DrugPindolol [13523-86-9]; Up 200; 16.2uM; PC3; HT_HG-U133A

MYH11 LATS1 TNN ATM ECE1 SMG6 TXK

1.48e-051989174496_UP
Drugcaffeine

MGAM PARP1 ENPP7 TPCN2 PDE8A LTN1 ATM PLD1 RYR1 CA2 PDE11A

1.49e-055629111CID000002519
DrugS(+)-Terguride [37686-84-3]; Down 200; 11.8uM; HL60; HT_HG-U133A

DENND5B CAPN3 SUGP1 LAMA2 FGL1 MCTP2 ITPR2

1.53e-051999173082_DN
DrugSulfadimethoxine [122-11-2]; Up 200; 12.8uM; PC3; HT_HG-U133A

MGAM AKR1D1 SLAMF7 ECE1 TSPAN9 PDE11A ITPR2

1.53e-051999173702_UP
DrugIopanoic acid [96-83-3]; Up 200; 7uM; MCF7; HT_HG-U133A

RELN LATS1 PLD1 KIT PCM1 PDE11A ITPR2

1.53e-051999175448_UP
Drugcolchicine; Down 200; 0.1uM; MCF7; HG-U133A

KIDINS220 SUGP1 DHX57 OAS3 HMGCS1 XAB2 ECE2

1.53e-05199917644_DN
DrugSaquinavir mesylate [149845-06-7]; Down 200; 5.2uM; HL60; HT_HG-U133A

DENND5B CSE1L KIDINS220 CAPN3 SUGP1 TSPAN9 PCM1

1.58e-052009176127_DN
DrugFoliosidine [2520-38-9]; Up 200; 13uM; MCF7; HT_HG-U133A

RELN LATS1 TTLL4 CHD7 ECE1 CPED1 PCM1

1.58e-052009176057_UP
Drugsertaconazole

SLC17A5 RELN CSE1L EIF3B SNAP25 PCM1 DHX8

2.91e-05220917CID000065863
DrugTCAT

PARP1 DPYD ATM

3.33e-0516913CID000013153
Drug1,4-anthraquinone

MGAM PARP1 CAPN3

4.03e-0517913CID000069457
Drugfluorine atom

MGAM SUGP1 SLAMF7 CA2

4.41e-0549914CID005360525
Drug7-deoxy-6-epi-castanospermine

MGAM CAPN3

4.73e-053912CID000125391
DrugAC1NUR2V

MGAM CAPN3

4.73e-053912CID005489114
Drugcallyspongynic acid

MGAM CAPN3

4.73e-053912CID000636783
DrugIPG7F

MGAM CAPN3

4.73e-053912CID003083273
DrugDPEC

FCGR3A FCGR3B

4.73e-053912CID000129670
DrugPradimicin Q

MGAM CAPN3

4.73e-053912CID000073572
Drug3-nitro-4-(6-aminohexylamido)phenylboronic acid

MGAM CAPN3

4.73e-053912CID000133488
Drugglycerol-3-phosphocholine

MGAM ENPP7 PDE8A CAPN3 PLD1 PDE11A

6.68e-05172916CID000000823
Druguranium

MGAM LATS1 POLR2B KIF1B THOC2 XAB2 DHX8

6.87e-05252917CID000023989
DrugAC1NRD8M

MGAM KIDINS220 CAPN3 SNAP25

8.59e-0558914CID005289405
DrugK-Cl

MGAM RELN MYH11 EEF2K FAM3B SNAP25 PLD1 RYR1 CA2 SMG6

8.92e-055679110CID000004873
Drugpay off

MYH11 MSH2 MAP2K3 TXK

9.19e-0559914CID000050980
Drugmyrciaphenone B

MGAM CAPN3

9.43e-054912CID000183139
DrugNSC277293

MGAM CAPN3

9.43e-054912CID000321973
Druggamma-glutamyl-2-naphthylamide

MGAM CAPN3

9.43e-054912CID000164706
Drugatalaphyllidine

MGAM CAPN3

9.43e-054912CID005479542
DrugSensodyne

TNN RYR1

9.43e-054912CID000010589
Drugglycovir

MGAM CAPN3

9.43e-054912CID000060807
Drugthiochroman-4-one

MGAM CAPN3

9.43e-054912CID000019048
Drug2-deoxymaltose

MGAM CAPN3

9.43e-054912CID003081508
DrugAC1L3RZ0

MGAM CAPN3

9.43e-054912CID000145814
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; HL60; HT_HG-U133A

PARP1 FARSA CSE1L PKP4 MSH2 EIF3B

9.98e-051859161833_DN
DrugNocodazole [31430-18-9]; Up 200; 13.2uM; PC3; HT_HG-U133A

HINFP SLC17A5 NRXN3 TTLL4 SUGP1 LGR5

1.16e-041909167145_UP
DrugC75; Down 200; 10uM; PC3; HT_HG-U133A

PKP4 TBC1D2B LAMA2 ECE1 PCM1 TXK

1.19e-041919166399_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A

SLC17A5 TBC1D2B SUGP1 ATM TSPAN9 PCM1

1.22e-041929164743_DN
DrugTiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; HL60; HG-U133A

MGAM PKP4 ATM MAP2K3 PCM1 DHX8

1.26e-041939161412_DN
Drug6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; PC3; HT_HG-U133A

NRXN3 TTLL4 TENM1 SUGP1 ATM ECE1

1.26e-041939164477_UP
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; HL60; HT_HG-U133A

KIDINS220 PKP4 ATM FGL1 MCTP2 PCM1

1.29e-041949162430_DN
DrugSTOCK1N-35215; Down 200; 10uM; PC3; HT_HG-U133A

DENND5B ECE1 CPED1 PCM1 RYR1 CA2

1.29e-041949166380_DN
DrugBepridil hydrochloride [74764-40-2]; Up 200; 10uM; HL60; HT_HG-U133A

PDE8A SUGP1 LAMA2 DHX57 PLD1 MCTP2

1.29e-041949161274_UP
DrugHaloperidol [52-86-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A

LATS1 HMGCS1 FGL1 MAP2K3 MCTP2 TSPAN9

1.33e-041959161539_UP
DrugPiperidolate hydrochloride [129-77-1]; Down 200; 11.2uM; HL60; HT_HG-U133A

PKP4 CAPN3 DHX57 ATM PLD1 PCM1

1.33e-041959166129_DN
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ATM FGL1 ECE1 XAB2 SMG6 ITPR2

1.33e-041959163893_DN
DrugAscorbic acid [50-81-7]; Up 200; 22.4uM; MCF7; HT_HG-U133A

TBC1D2B SUGP1 OAS3 PLD1 FGL1 TSPAN9

1.37e-041969165407_UP
DrugCP-320650-01 [172079-28-6]; Down 200; 1uM; PC3; HT_HG-U133A

LATS1 NRXN3 PKP4 ECE1 CPED1 TSPAN9

1.37e-041969164560_DN
DrugEnoxacin [74011-58-8]; Up 200; 12.4uM; MCF7; HT_HG-U133A

DENND5B PLD1 SLAMF7 KIT PCM1 ITPR2

1.37e-041969165251_UP
DrugScoulerine [6451-73-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A

LATS1 MCTP1 SUGP1 LAMA2 ECE1 CPED1

1.37e-041969165536_UP
DrugMifepristone [84371-65-3]; Down 200; 9.4uM; PC3; HT_HG-U133A

CSE1L TTLL4 SUGP1 ATM ECE1 TSPAN9

1.37e-041969165827_DN
DrugCanavanine sulfate monohydrate (L,+) [206996-57-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A

ARHGAP12 PCMTD2 MSH2 ATM TSPAN9 CA2

1.37e-041969164782_DN
DrugNortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; PC3; HT_HG-U133A

CSE1L CHD7 HMGCS1 LGR5 TSPAN9 ITPR2

1.37e-041969167300_UP
DrugThyroxine (L) [51-48-9]; Up 200; 5.2uM; PC3; HT_HG-U133A

NRXN3 AKR1D1 LAMA2 SLAMF7 PDE11A ITPR2

1.41e-041979164069_UP
DrugCinnarizine [298-57-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A

CSE1L KIDINS220 MCTP1 ATM ECE1 PCM1

1.41e-041979167174_UP
DrugDihydroergotamine tartrate [5989-77-5]; Up 200; 3uM; PC3; HT_HG-U133A

MYH11 NRXN3 TTLL4 LAMA2 ECE1 TXK

1.41e-041979164502_UP
DrugPiperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; PC3; HT_HG-U133A

NRXN3 BEND5 SUGP1 CPED1 SMG6 ITPR2

1.41e-041979163763_DN
DrugStreptomycin sulfate [3810-74-0]; Down 200; 2.8uM; HL60; HG-U133A

HINFP MGAM PCMTD2 SNAP25 MAP2K3 PCM1

1.41e-041979161578_DN
DrugIpratropium bromide [22254-24-6]; Up 200; 9.8uM; PC3; HT_HG-U133A

SLC17A5 NRXN3 SUGP1 DHX57 CHD7 MCTP2

1.41e-041979165823_UP
DrugNalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A

RELN CSE1L HMGCS1 FGL1 TSPAN9 PCM1

1.41e-041979167177_UP
DrugTerbutaline hemisulfate [23031-32-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A

PKP4 TTLL4 SUGP1 DHX57 PCM1 LRRFIP2

1.41e-041979166240_DN
DrugDihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; PC3; HT_HG-U133A

SLC17A5 PKP4 SUGP1 OAS3 TSPAN9 LRRFIP2

1.45e-041989167275_DN
DrugBetonicine [515-25-3]; Up 200; 25.2uM; PC3; HT_HG-U133A

LATS1 PKP4 SUGP1 CPED1 PCM1 ITPR2

1.45e-041989164301_UP
DrugAntipyrine [60-80-0]; Up 200; 21.2uM; PC3; HT_HG-U133A

BEND5 PKP4 TENM1 PLD1 KIT MCTP2

1.45e-041989164251_UP
DrugFluspirilen [1841-19-6]; Down 200; 8.4uM; MCF7; HT_HG-U133A

CSE1L MCTP1 SUGP1 ZNF721 TSPAN9 CA2

1.45e-041989166463_DN
DrugTrimethadione [127-48-0]; Up 200; 28uM; HL60; HT_HG-U133A

RELN PKP4 LAMA2 FGL1 TSPAN9 RYR1

1.45e-041989162486_UP
DrugCeforanide [60925-61-3]; Up 200; 7.6uM; PC3; HT_HG-U133A

BEND5 PKP4 TENM1 SUGP1 LAMA2 MCTP2

1.45e-041989166751_UP
DrugPF-00562151-00 [351320-12-2]; Up 200; 10uM; PC3; HT_HG-U133A

MCTP1 PDE8A TTLL4 ARHGAP12 OAS3 TSPAN9

1.45e-041989166907_UP
Drug1,1-dimethylbiguanide hydrochloride; Down 200; 10uM; MCF7; HG-U133A

HINFP KIDINS220 CAPN3 OAS3 PCM1 XAB2

1.49e-0419991661_DN
DrugMethylhydantoin-5-(D) [55147-68-7]; Down 200; 35uM; PC3; HT_HG-U133A

SUGP1 SLAMF7 LGR5 CPED1 PCM1 TXK

1.49e-041999163994_DN
DrugNomifensine maleate [32795-47-4]; Up 200; 11.2uM; PC3; HT_HG-U133A

NRXN3 SUGP1 PLD1 CPED1 TSPAN9 SMG6

1.49e-041999162062_UP
DrugBenzathine benzylpenicillin [5928-84-7]; Down 200; 4.2uM; MCF7; HT_HG-U133A

KIDINS220 TTLL4 SUGP1 ATM PCM1 SMG6

1.49e-041999164140_DN
DrugPHA-00745360 [351320-33-7]; Down 200; 1uM; PC3; HT_HG-U133A

LATS1 NRXN3 TENM1 SUGP1 ECE1 CPED1

1.49e-041999164562_DN
DrugPiperine [94-62-2]; Up 200; 14uM; PC3; HT_HG-U133A

NRXN3 PKP4 AKR1D1 SUGP1 LAMA2 SLAMF7

1.49e-041999164247_UP
DrugRibavirin [36791-04-5]; Up 200; 16.4uM; MCF7; HT_HG-U133A

KIDINS220 EFCAB6 LAMA2 ATM SNAP25 PDE11A

1.49e-041999166521_UP
DrugTubocurarine chloride pentahydrate (+) [6989-98-6]; Up 200; 5.2uM; MCF7; HT_HG-U133A

RELN TTLL4 CPED1 TSPAN9 PCM1 ITPR2

1.49e-041999165449_UP
DrugCanavanine sulfate monohydrate (L,+) [206996-57-8]; Up 200; 13.6uM; PC3; HT_HG-U133A

KIDINS220 TTLL4 CAPN3 LAMA2 FGL1 ITPR2

1.49e-041999164197_UP
DrugLevodopa [59-92-7]; Up 200; 20.2uM; PC3; HT_HG-U133A

LATS1 TBC1D2B TENM1 PLD1 FGL1 SMG6

1.49e-041999164571_UP
Drugtelomestatin

MSH2 MAP2K3 SMG6

1.50e-0426913CID000443590
DrugSchiff's reagent

LATS1 SLAMF7 ECE1

1.50e-0426913CID000010484
DrugEpirizole [18694-40-1]; Down 200; 17uM; MCF7; HT_HG-U133A

SLC17A5 KIDINS220 PKP4 TTLL4 SUGP1 MAP2K3

1.53e-042009161681_DN
DrugS-acetylthioacetic acid

HPR ECE1

1.57e-045912CID000014485
Drugtetrachlorophthalimide

MGAM CAPN3

1.57e-045912CID000074077
DrugD-gluco-octenitol

MGAM CAPN3

1.57e-045912CID006438548
DrugBn-4

FCGR3A FCGR3B

1.57e-045912CID006452014
Drug(-)-Lentiginosine

MGAM CAPN3

1.57e-045912CID000130407
Drugbeta-D-glucopyranosyl azide

MGAM CAPN3

1.57e-045912CID000152302
Drugpulmatin

MGAM CAPN3

1.57e-045912CID000442731
DrugRo 22-0654

MGAM CAPN3

1.57e-045912CID000133753
Drugcaged InsP3

CLCA4 RYR1 CA2

2.09e-0429913CID000122248
Drugmagnesium

MGAM ENPP7 FARSA MYH11 CSE1L PDE8A POLR2B ARPC1A LAMA2 MRPL13 MSH2 SNAP25 PLD1 RYR1 CA2

2.31e-0413259115CID000000888
DrugNsc1222

MGAM HPR CAPN3

2.32e-0430913CID000219660
DrugTAN-1030A

FCGR3A FCGR3B

2.35e-046912CID009576886
Drugbismaleimide

FCGR3A FCGR3B

2.35e-046912CID000083648
DrugAC1OCFTL

MGAM CAPN3

2.35e-046912CID006918743
Diseaselevel of low affinity immunoglobulin gamma Fc region receptor III-A in blood serum

FCGR3A FCGR3B

9.41e-062912OBA_2040305
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a measurement

FCGR3A FCGR3B SLAMF7

1.87e-0517913EFO_0021969
DiseaseLupus Vasculitis, Central Nervous System

FCGR3A FCGR3B

2.82e-053912C0752332
DiseaseLupus Meningoencephalitis

FCGR3A FCGR3B

2.82e-053912C0752334
DiseaseNeuropsychiatric Systemic Lupus Erythematosus

FCGR3A FCGR3B

2.82e-053912C0752335
Diseasetea consumption measurement

MGAM NRXN3 SUGP1 LAMA2 PCMTD2

5.08e-05129915EFO_0010091
DiseaseAcute myelomonocytic leukemia

MYH11 KIT

9.35e-055912C0023479
DiseaseAutism Spectrum Disorders

DPYD RELN NRXN3 CA2

1.42e-0485914C1510586
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a/b measurement

FCGR3A FCGR3B

1.96e-047912EFO_0008211
Diseasepermanent dental caries

MGAM PDE11A

1.96e-047912EFO_0600096
DiseaseAdenocarcinoma of large intestine

EEF2K MSH2 ATM KIT

2.26e-0496914C1319315
Diseaserenal cell carcinoma

ATM PLD1 ITPR2

2.99e-0442913EFO_0000681
Diseasearthritis (is_implicated_in)

PARP1 FCGR3A

3.34e-049912DOID:848 (is_implicated_in)
Diseaseplexin-B2 measurement

FCGR3A FCGR3B

3.34e-049912EFO_0021867
Diseaseresponse to hydrochlorothiazide, diastolic blood pressure change measurement

ENPP7 TTC6

4.17e-0410912EFO_0005202, EFO_0006945
Diseasetelomere length

PARP1 NRXN3 MCTP1 ATM TERF1 TSPAN9

4.25e-04313916EFO_0004505
Diseaseaspartate aminotransferase measurement

SLC17A5 FCGR3A FCGR3B HPR SUGP1 LY75 TSPAN9 TTC6 SMG6 TXK

4.74e-049049110EFO_0004736
DiseaseCongenital muscular dystrophy

LAMA2 RYR1

6.08e-0412912cv:C0699743
Diseasebasophil count

FCGR3A FCGR3B CAPN3 ECE1 KIT YTHDF2 RYR1

7.47e-04483917EFO_0005090
Diseaselow affinity immunoglobulin gamma Fc region receptor III-B measurement

FCGR3A FCGR3B

8.36e-0414912EFO_0008212
Diseasebasophil percentage of leukocytes

FCGR3A FCGR3B CHD7 ECE1 RYR1

9.51e-04243915EFO_0007992
Diseasehemoglobin A1 measurement

MGAM FARSA PLD1 GPSM1 MAP2K3 YTHDF2 SMG6

1.15e-03520917EFO_0007629
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

DNHD1 RPL14 ATM RYR1

1.16e-03148914C0279702
Diseasemuscular dystrophy (is_implicated_in)

CAPN3 LAMA2

1.24e-0317912DOID:9884 (is_implicated_in)
Diseasecancer (implicated_via_orthology)

LATS1 MSH2 ATM GPSM1 KIT

1.47e-03268915DOID:162 (implicated_via_orthology)
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

FOXL2 MSH2

1.55e-0319912DOID:2876 (is_marker_for)
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

MSH2 ATM

1.55e-0319912C2936783
DiseaseColorectal Neoplasms

PARP1 DPYD FOXL2 MSH2 LGR5

1.69e-03277915C0009404
Diseasedisease of metabolism (implicated_via_orthology)

YTHDF1 YTHDF2

1.90e-0321912DOID:0014667 (implicated_via_orthology)
DiseaseImmunologic Deficiency Syndromes

CHD7 ATM

2.28e-0323912C0021051
DiseaseMalignant neoplasm of stomach

DPYD MRPL13 MSH2 ATM CA2

2.40e-03300915C0024623
Diseasepeptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease

DPYD TERF1

2.48e-0324912EFO_0003948, EFO_0009923, MONDO_0004247
Diseaseunipolar depression, neuroticism measurement

KIAA1217 TSPAN9

2.48e-0324912EFO_0003761, EFO_0007660
Diseaselow affinity immunoglobulin gamma Fc region receptor II-b measurement

FCGR3A FCGR3B

2.69e-0325912EFO_0021970
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

MSH2 ATM

2.91e-0326912C0009405
Diseasesensory perception of bitter taste

MGAM MCTP2

2.91e-0326912GO_0050913

Protein segments in the cluster

PeptideGeneStartEntry
DLRSIYKKDGWNQNH

PKP4

996

Q99569
YKKDGWNQNHFITPV

PKP4

1001

Q99569
KWHQLQVTQGDSKYT

BEND5

311

Q7L4P6
ANYGKARSWYLKAQH

SMG6

746

Q86US8
NVVDCKLHWQKNGDY

EIF3B

511

P55884
EWQKVHGTKFYHNVN

CPED1

796

A4D0V7
THFWNDENGNKYRKA

AACS

496

Q86V21
ENGKWLYHKSNLCAT

AKR1D1

136

P51857
ESVNDGKQASWYIHK

DPYD

491

Q12882
AKTLSQAQCGQYHKW

DNHD1

3396

Q96M86
YQWDGNLKPQAKSAH

DNHD1

3521

Q96M86
LNHYKGDENIKSFIW

CHD7

1651

Q9P2D1
EVHIYKKNGSQWVKA

ARPC1A

31

Q92747
YCKKIHAQWQKEGND

HMGCS1

236

Q01581
KLYEEKTGNAWHSKN

PARP1

616

P09874
QYWKAKQAKQGNHTE

ITPR2

71

Q14571
SQNKFWKYGKHSVPQ

LTN1

256

O94822
AWIVYNKPKHAELAN

ANAPC1

1156

Q9H1A4
DNKTALYWAVEKGNA

KIDINS220

301

Q9ULH0
ISGGKETQHDVWKYN

KLHL6

381

Q8WZ60
LTHTVYKNLNPEWNK

MCTP1

661

Q6DN14
HTVYKNLNPEWNKVF

MCTP2

546

Q6DN12
SQTKLQEKYNSWHHG

KIT

251

P10721
NVNDTLNGWYKNGKH

LATS1

1056

O95835
NIGNVYHAKGKQLSW

GPSM1

151

Q86YR5
YHAKGKQLSWNAANA

GPSM1

156

Q86YR5
WGQSDNFKLTDHLKY

HPR

226

P00739
AVEVQDLKNGATHYW

KIF1B

826

O60333
DAVQHWGKQYDIHNL

MGAM

571

O43451
NAYKAWLRKHGEEQQ

ECE2

721

P0DPD6
HNSYNGKETKNRWKN

PCM1

941

Q15154
FKENAYKDLAWKHGN

PCMTD2

46

Q9NV79
VSKGEYDWNIKNHRD

PDE11A

791

Q9HCR9
DLMQHLDNNFKYWKG

PDE8A

801

O60658
YEKNKKGWQNSIRHN

FOXL2

91

P58012
KATQKKANDGEWYHV

NRXN3

531

Q9Y4C0
YAGQKLNDNEWHTVR

NRXN3

766

Q9Y4C0
AAKENGSRWIQYKGH

LY75

1531

O60449
KKFTDYHQWNSAGVG

GOLGA6L7

16

A0A1B0GV03
VVSNQNHNDGKWKSF

LAMA2

2411

P24043
KINHSDAKNNRYSGW

FAM3B

206

P58499
QQKEYSLHSFDRKWG

LRRFIP2

56

Q9Y608
SVQLQYSLNNGKDWH

RELN

1681

P78509
NEKWLKHVDDQGRQY

ARHGAP12

361

Q8IWW6
HSDSKQGKYLNWDAV

ATM

46

Q13315
QAHQYLVTKAKNRWS

EFCAB6

836

Q5THR3
NFVQKHGEYWLGNKN

FGL1

146

Q08830
RYDWQAKSVHAENGK

DHX57

506

Q6P158
KSKVLAHYPQNIEWN

DENND5B

56

Q6ZUT9
WKNTALHKVTYLQNG

FCGR3B

131

O75015
NWYVDGVEVHNAKTK

IGHG4

156

P01861
LHAQQWKGASNYVAK

EEF2K

156

O00418
KGLKYNQATQTFHQW

ENAH

66

Q8N8S7
AYQNWVKKNGAEHSL

ECE1

681

P42892
GIAHNYKNETEWRAN

ENPP7

161

Q6UWV6
WKNTALHKVTYLQNG

FCGR3A

131

P08637
YHTKLKQWGLQALQS

HINFP

91

Q9BQA5
AWQKIFKHYDTDQSG

CAPN3

726

P20807
KVHHNQTGKKYQWDA

SLC17A5

91

Q9NRA2
EQLAENYHNTWGRKK

RYR1

2876

P21817
NYHNTWGRKKKQELE

RYR1

2881

P21817
RAGNKASKENDWYLA

MSH2

106

P43246
LAVYNSWKNNKFSNP

DHX8

1046

Q14562
ENAYKISNQWNKGDN

LGR5

486

O75473
KHWYRQVAAQNKGKG

OAS3

606

Q9Y6K5
NQKGYNVKSDVWSLG

MAP2K3

241

P46734
SKAGKSNYQLWHELC

XAB2

211

Q9HCS7
SYHQGLKKWVEVGNS

FARSA

421

Q9Y285
IQENALAKWYVNAKG

PLD1

346

Q13393
WHKFSQGQAAVTIQK

IQCA1L

201

A6NCM1
YSLATGNWGDQKKAH

POLR2B

446

P30876
KWEEKRQNLDHYNGK

KIAA1217

971

Q5T5P2
NGLLQKAYNKASGWT

TENM1

2231

Q9UKZ4
KSSDAYKKAWGNNQD

SNAP25

96

P60880
YKKAWGNNQDGVVAS

SNAP25

101

P60880
VHWNTKYGDFGKAVQ

CA2

121

P00918
KVGTWAYNLQAKANP

CLCA4

561

Q14CN2
AGKVDYNASAWLTKN

MYH11

581

P35749
LWEKAVQQHQHGYDS

SUGP1

471

Q8IWZ8
YAKNPSVNWKHKDAA

CSE1L

416

P55060
QWKNETYNSHPLLVK

THOC2

526

Q8NI27
LQAQGKFQKAWNHFT

TTC6

291

Q86TZ1
YTVHVWAQKGNQESK

TNN

861

Q9UQP3
HSAHQKYVRQAWQKA

RPL14

66

P50914
GKDFGWYTDLNQHKK

ZNF721

131

Q8TF20
VYGWTQHKFHQLKQE

TMEM116

191

Q8NCL8
GNWSKILLHYKFNNR

TERF1

401

P54274
IYTWKALGQAANESH

SLAMF7

161

Q9NQ25
AFSGNKWEQKVYSSH

MRPL13

66

Q9BYD1
NAYHQETWKRNKTFN

ZNF404

66

Q494X3
KKNDSGQWYVAERHA

TXK

206

P42681
NILTTQWEQKYHGNK

TTLL4

1046

Q14679
QWEQKYHGNKLKGVD

TTLL4

1051

Q14679
NFYSLKQWGNELKNS

TBC1D2B

216

Q9UPU7
GYDWHQAALAKTLQQ

TSHZ1

196

Q6ZSZ6
SVKGYLFGWAHFQKN

TPCN2

141

Q8NHX9
YHTENNVGLKNAWNI

TSPAN9

126

O75954
NNYNPKDFDWNLKHG

YTHDF2

396

Q9Y5A9
LKAAHSYNPKEFEWN

YTHDF1

371

Q9BYJ9