Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Ricin_B_lectin	GALNT6 GALNT3	1.24e-03	25	39	2	PF00652
Domain	RICIN	GALNT6 GALNT3	1.55e-03	28	39	2	SM00458
Domain	RICIN_B_LECTIN	GALNT6 GALNT3	1.55e-03	28	39	2	PS50231
Domain	Glyco_trans_2-like	GALNT6 GALNT3	1.78e-03	30	39	2	IPR001173
Domain	Ricin_B_lectin	GALNT6 GALNT3	1.78e-03	30	39	2	IPR000772
Domain	Glycos_transf_2	GALNT6 GALNT3	1.78e-03	30	39	2	PF00535
Domain	Quinoprotein_ADH-like_supfam	WDR1 PWP2	5.47e-03	53	39	2	IPR011047
Domain	VWA	COL6A5 ITIH3	6.09e-03	56	39	2	PF00092
Domain	-	COL6A5 ITIH3	1.04e-02	74	39	2	3.40.50.410
Domain	-	GALNT6 GALNT3	1.24e-02	81	39	2	3.90.550.10
Domain	VWFA	COL6A5 ITIH3	1.27e-02	82	39	2	PS50234
Domain	VWA	COL6A5 ITIH3	1.33e-02	84	39	2	SM00327
Domain	G-protein_beta_WD-40_rep	WDR1 PWP2	1.36e-02	85	39	2	IPR020472
Domain	Nucleotide-diphossugar_trans	GALNT6 GALNT3	1.45e-02	88	39	2	IPR029044
Pubmed	Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.	GALNT6 GALNT3	1.23e-06	2	39	2	31932717
Pubmed	The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression.	GALNT6 GALNT3	1.23e-06	2	39	2	31071912
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SHANK1 TPPP ARHGEF12 HRG WDR1 PRKAG2 BSN PBXIP1 CEP170B PRRC2B	2.88e-06	1431	39	10	37142655
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	ARHGEF12 CCDC22 WASHC2A CEP170B PRRC2B	8.86e-06	251	39	5	29778605
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 TPPP ARHGEF12 WDR1 WIZ BSN CEP170B PRRC2B	9.64e-06	963	39	8	28671696
Pubmed	The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization.	GALNT6 GALNT3	1.22e-05	5	39	2	12506059
Pubmed	IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.	SHANK1 BSN	1.22e-05	5	39	2	21940441
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ARHGEF12 KMT2C WIZ RAB11FIP1 GALNT3 PBXIP1 SPTY2D1 CEP170B PWP2	3.26e-05	1497	39	9	31527615
Pubmed	Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea.	SHANK1 BSN	3.42e-05	8	39	2	23217150
Pubmed	Superresolution imaging of chemical synapses in the brain.	SHANK1 BSN	4.39e-05	9	39	2	21144999
Pubmed	Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.	HRG COL6A5 MXRA5	4.71e-05	62	39	3	28344315
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	IRF2BP2 MXRA5 IDE GALNT3 BSN PRRC2B	7.26e-05	638	39	6	31182584
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ARHGEF12 STON1 WASHC2A CEP170B	8.84e-05	209	39	4	36779422
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	TPPP BSN	1.11e-04	14	39	2	16452088
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	IRF2BP2 RPRD2 WIZ SPTY2D1	1.12e-04	222	39	4	37071664
Pubmed	Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.	CCDC22 WASHC2A	1.27e-04	15	39	2	28892079
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	TPPP BSN CEP170B PRRC2B	1.30e-04	231	39	4	16452087
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CCDC22 IDE PBXIP1 SPTY2D1 PRRC2B PWP2	1.80e-04	754	39	6	33060197
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	CCDC22 WASHC2A	2.07e-04	19	39	2	25355947
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	JAG2 KMT2C RPRD2 IDE PRKAG2 RPS6KL1 CEP170B INKA2	2.08e-04	1489	39	8	28611215
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	IRF2BP2 RPRD2 WIZ PRRC2B	2.29e-04	268	39	4	33640491
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	IRF2BP2 RPRD2 WDR1 WIZ WASHC2A	2.45e-04	506	39	5	30890647
Pubmed	Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.	GALNT6 GALNT3	2.79e-04	22	39	2	25107907
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT6 GALNT3	3.33e-04	24	39	2	31740596
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT6 GALNT3	3.33e-04	24	39	2	31882545
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	IRF2BP2 PRRC2B	3.33e-04	24	39	2	33722704
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2C RPRD2 CCDC22 WIZ PRRC2B	3.56e-04	549	39	5	38280479
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	IRF2BP2 RPRD2 WIZ	4.62e-04	134	39	3	25452129
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TACC2 BSN WASHC2A CEP170B PRRC2B	4.86e-04	588	39	5	38580884
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	IRF2BP2 RPRD2 TACC2 WDR1 WIZ PRRC2B	5.65e-04	934	39	6	33916271
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	GALNT6 GALNT3	7.54e-04	36	39	2	25615642
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	CCDC22 WIZ RAB11FIP1 PBXIP1 SPTY2D1 PRRC2B	8.37e-04	1007	39	6	34597346
Pubmed	O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.	GALNT6 GALNT3	9.30e-04	40	39	2	22643896
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	WDR1 PWP2	9.30e-04	40	39	2	25011449
Pubmed	Human transcription factor protein interaction networks.	IRF2BP2 KMT2C RPRD2 WDR1 WIZ WASHC2A PRRC2B	9.45e-04	1429	39	7	35140242
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	KMT2C RAB11FIP1	9.77e-04	41	39	2	34638806
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	KMT2C IDE WIZ PWP2	1.01e-03	398	39	4	35016035
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGEF12 WASHC2A CEP170B PRRC2B	1.10e-03	407	39	4	12693553
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT6 GALNT3	2.41e-04	20	21	2	433
GeneFamily	PDZ domain containing	SHANK1 ARHGEF12	1.33e-02	152	21	2	1220
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAG2 TPPP STON1 CXCR2	1.07e-05	157	39	4	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT6 BSN SPTY2D1 CXCR2	1.56e-05	173	39	4	3612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT6 BSN SPTY2D1 CXCR2	1.56e-05	173	39	4	4dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAG2 BEST3 PRKAG2 BSN	1.60e-05	174	39	4	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF12 GALNT6 WASHC2A CXCR2	2.30e-05	191	39	4	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	CV-Moderate-6\|Moderate / Virus stimulation, Condition and Cluster	IRF2BP2 KMT2C GALNT6 SPTY2D1	2.50e-05	195	39	4	2b8a72d7e755b9655c7a496000d10ff06e50862b
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	IRF2BP2 KMT2C GALNT6 SPTY2D1	2.55e-05	196	39	4	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TACC2 PRKAG2 PBXIP1 INKA2	2.71e-05	199	39	4	a207b4891881149d4c50721310690fd794157723
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	GALNT6 STON1 RAB11FIP1 PBXIP1	2.76e-05	200	39	4	be83f442179ba4217d12f0458059586ff3130991
Disease	hypertension	ARHGEF12 COL6A5 STON1 PRKAG2	6.42e-04	307	38	4	EFO_0000537
Disease	differentiated thyroid carcinoma	STON1 PRKAG2	9.35e-04	35	38	2	EFO_1002017
Disease	unipolar depression, bipolar disorder	SPPL3 RPRD2 ITIH3	1.07e-03	156	38	3	EFO_0003761, MONDO_0004985
Disease	memory performance	ARHGEF12 BEST3 PRKAG2 ITIH3	1.85e-03	409	38	4	EFO_0004874
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	SPPL3 RPS6KL1 ITIH3	2.17e-03	200	38	3	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	hepcidin:ferritin ratio	TACC2 STON1	2.30e-03	55	38	2	EFO_0007901
Disease	cortical thickness	JAG2 ARHGEF12 IRF2BP2 TACC2 STON1 PRKAG2	2.79e-03	1113	38	6	EFO_0004840
Disease	stem Cell Growth Factor beta measurement	SHANK1 RPS6KL1	4.22e-03	75	38	2	EFO_0008292
Disease	red blood cell density measurement	IRF2BP2 PNPLA1 STON1 PRKAG2 ITIH3	5.18e-03	880	38	5	EFO_0007978
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	TACC2 WDR1	5.77e-03	88	38	2	EFO_0803332

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKSCFPEGSPTLHFS	BEST3	451	Q8N1M1
GKHSSRKVDSPFGPG	PRKAG2	56	Q9UGJ0
SFTHSPSGDPKADKR	CEP170B	421	Q9Y4F5
GAPKGSRFTHSEKFT	CCDC22	286	O60826
PKPSHGGKFCEGSTR	ADAMTS16	616	Q8TE57
VTEHGTPKPFRKFDS	ARHGEF12	731	Q9NZN5
KGPIAAGTSDHFTKP	KMT2C	1996	Q8NEZ4
SSTTKPPFKPHGSRD	HRG	271	P04196
RSLSKGSGHFPFPGT	INKA2	251	Q9NTI7
FLSHKFTKDPGRSPG	JAG2	1196	Q9Y219
KLPFGSSCTGTFHPA	BSN	1906	Q9UPA5
PPTKPGSRSKAAFHD	FSIP2	1051	Q5CZC0
AFFGTKKGHSPSPAA	PGLYRP4	151	Q96LB8
PKDSRPSFVGSSSGH	CXCR2	341	P25025
FKGDPDTPHSISFSG	PNPLA1	6	Q8N8W4
TSGTRKGFPRHSGSK	PNPLA1	511	Q8N8W4
VFRSKSPHSFPKGTQ	GALNT3	416	Q14435
GHVFRTKSPHTFPKG	GALNT6	406	Q8NCL4
DSSDHLGPKSFPFVK	COL6A5	36	A8TX70
HSTTQPRKTKGSGFF	IGHE	371	P01854
KATGNPKHPFSKFGT	IDE	206	P14735
SDDKHFGQAPSKGTP	RPRD2	1021	Q5VT52
GHSGPFESKFKKEPA	IRF2BP2	316	Q7Z5L9
SSSPSPKGFRKKHLF	RAB11FIP1	341	Q6WKZ4
SFSGKKGHVSFKPSL	ITIH3	216	Q06033
PFTKKFRSAGHGRDS	WIZ	1461	O95785
GPPFKFKFTIGDHSR	WDR1	176	O75083
KPVFNGAGKPHSSTS	SPTY2D1	306	Q68D10
SLGKHRPKGFFATES	SHANK1	846	Q9Y566
RPKGFFATESSFDPH	SHANK1	851	Q9Y566
PPRKSGSFHSSGEKQ	PBXIP1	541	Q96AQ6
GSDSHFTLDPPGSKK	STON1	191	Q9Y6Q2
RKLHSPTSSAKGFSG	TBC1D8B	1031	Q0IIM8
KGSVHSVSFSPDGRK	PWP2	96	Q15269
PGKLVFPSSTGSHFS	SPPL3	251	Q8TCT6
KGPGHATFGREATKF	PRRC2B	1006	Q5JSZ5
GEGGVSKLKSHPFFS	RPS6KL1	526	Q9Y6S9
KETSPSHPGFKDQGA	TACC2	856	O95359
DFFSAPHSKPSKTGK	WASHC2A	461	Q641Q2
KFTGSHKERFDPSGK	TPPP	171	O94811
KGSTFRPHDSFPKSG	KIAA1522	136	Q9P206
QSSSKFFAGGPPASK	MXRA5	1831	Q9NR99