Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlactate transmembrane transporter activity

SLC16A1 SLC16A8

2.25e-056252GO:0015129
GeneOntologyMolecularFunctionglycosaminoglycan binding

HAPLN4 RSPO4 COL17A1 MDK

3.21e-04268254GO:0005539
GeneOntologyMolecularFunctionextracellular matrix structural constituent

HAPLN4 COL17A1 SSPOP

1.62e-03188253GO:0005201
GeneOntologyMolecularFunctionheparin binding

RSPO4 COL17A1 MDK

1.72e-03192253GO:0008201
GeneOntologyBiologicalProcesslactate transport

SLC16A1 SLC16A8

5.05e-059252GO:0015727
GeneOntologyBiologicalProcesslactate transmembrane transport

SLC16A1 SLC16A8

5.05e-059252GO:0035873
GeneOntologyCellularComponentcollagen-containing extracellular matrix

HAPLN4 LAMC3 CFP COL17A1 MDK SSPOP

3.03e-05530256GO:0062023
GeneOntologyCellularComponentextracellular matrix

HAPLN4 LAMC3 CFP COL17A1 MDK SSPOP

9.93e-05656256GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

HAPLN4 LAMC3 CFP COL17A1 MDK SSPOP

1.01e-04658256GO:0030312
DomainTSP1

CFP RSPO4 CILP2 SSPOP

1.60e-0665254SM00209
DomainTSP1_rpt

CFP RSPO4 CILP2 SSPOP

1.60e-0665254IPR000884
DomainTSP1

CFP RSPO4 CILP2 SSPOP

1.60e-0665254PS50092
DomainMCT

SLC16A1 SLC16A8

1.72e-055252IPR004743
DomainTSP_1

CFP CILP2 SSPOP

7.98e-0563253PF00090
Domain-

LAMC3 SSPOP

4.26e-03732522.60.120.260
DomainMFS

SLC16A1 SLC16A8

4.73e-0377252IPR011701
DomainMFS_1

SLC16A1 SLC16A8

4.73e-0377252PF07690
DomainGalactose-bd-like

LAMC3 SSPOP

6.97e-0394252IPR008979
DomainMFS

SLC16A1 SLC16A8

9.11e-03108252PS50850
DomainMFS_dom

SLC16A1 SLC16A8

1.38e-02134252IPR020846
Domain-

PLEKHA4 TRIOBP RGS12

1.49e-023912532.30.29.30
DomainGrowth_fac_rcpt_

LAMC3 RSPO4

1.83e-02156252IPR009030
DomainPH_dom-like

PLEKHA4 TRIOBP RGS12

1.87e-02426253IPR011993
PathwayREACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT

SLC16A1 SLC16A8

2.86e-056202MM17217
PathwayREACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT

SLC16A1 SLC16A8

2.86e-056202M27355
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A1 SLC16A8

5.18e-0424202MM17215
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A1 SLC16A8

5.63e-0425202M4974
Pubmed

Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development.

SLC16A1 SLC16A8

1.49e-06325216514190
Pubmed

Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.

SLC16A1 SLC16A8

2.97e-06425212657613
Pubmed

Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors.

SLC16A1 SLC16A8

4.95e-06525233999492
Pubmed

Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development.

SLC16A1 SLC16A8

4.95e-06525212056458
Pubmed

Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).

SLC16A1 SLC16A8

7.43e-06625215917240
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

CFP CILP2 SSPOP

2.14e-057525320637190
Pubmed

The glucose-lactic acid cycle and gluconeogenesis.

SLC16A1 SLC16A8

3.26e-05122527273846
Pubmed

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

SLC16A1 SLC16A8

4.49e-051425212739169
Pubmed

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.

TRIOBP RGS12

5.18e-051525236260679
Pubmed

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.

SLC16A1 SLC16A8

7.54e-051825231791063
Pubmed

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.

COL17A1 MDK SLC16A1 TNRC6A

3.92e-0449125436273042
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

SLC16A1 AVPR1A

6.43e-045225226590417
Cytoband19p13.11

CILP2 ANO8

7.31e-047325219p13.11
GeneFamilyActins|Deafness associated genes

TRIOBP SYNE4

5.55e-031131821152
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHA4 TRIOBP

1.75e-02206182682
CoexpressionNABA_CORE_MATRISOME

HAPLN4 LAMC3 RSPO4 CILP2 COL17A1 SSPOP

1.70e-07270256MM17057
CoexpressionNABA_CORE_MATRISOME

HAPLN4 LAMC3 RSPO4 CILP2 COL17A1 SSPOP

1.89e-07275256M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMC3 RSPO4 CILP2 SSPOP

3.07e-05191254MM17059
CoexpressionNABA_MATRISOME

HAPLN4 LAMC3 RSPO4 CILP2 COL17A1 MDK SSPOP

3.19e-051008257MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMC3 RSPO4 CILP2 SSPOP

3.39e-05196254M3008
CoexpressionNABA_MATRISOME

HAPLN4 LAMC3 RSPO4 CILP2 COL17A1 MDK SSPOP

3.57e-051026257M5889
ComputationalGenes in the cancer module 186.

SLC16A1 SLC16A8

2.15e-0420122MODULE_186
ComputationalGenes in the cancer module 71.

SLC16A1 SLC16A8

2.61e-0422122MODULE_71
ComputationalNeighborhood of FOS

CFP TPP1

9.14e-0441122GNF2_FOS
Diseasesyntaxin-1a measurement

RGS12 SARM1

6.33e-065242EFO_0020759
Disease17-beta-hydroxysteroid dehydrogenase 14 measurement

PLEKHA4 SARM1

6.33e-065242EFO_0802231
Diseaseschizophrenia (implicated_via_orthology)

MDK AVPR1A

1.40e-0368242DOID:5419 (implicated_via_orthology)
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

HAPLN4 RGS12 SARM1

1.42e-03276243EFO_0004612, EFO_0020943

Protein segments in the cluster

PeptideGeneStartEntry
VGGAGGGPWGPAPAW

COL17A1

441

Q9UMD9
GGPWGPAPAWCPCGS

COL17A1

446

Q9UMD9
PQSDPGSAWAGPWGG

DDN

181

O94850
WDGPWGCGGEGAAPR

ANO8

1151

Q9HCE9
GPPDGGWGWVVLGAC

SLC16A8

11

O95907
GGPVGYTPPDGGWGW

SLC16A1

6

P53985
GGPGSECAEWAWGPC

MDK

31

P21741
PCWSGGAGRGGGPAW

NFKBIE

51

O00221
VAGGWGPWGPVSPCP

CFP

256

P27918
GWPCGALGPGPHRWG

COQ8B

21

Q96D53
APGAPDPAPGGWGWG

HAPLN4

366

Q86UW8
PSSWPGEWGPGFRAG

SOHLH1

311

Q5JUK2
QGECELGPWGGWSPC

RSPO4

136

Q2I0M5
PGPGGEWGPWSPCSV

SSPOP

3041

A2VEC9
EWGPWSPCSVPCGGG

SSPOP

3046

A2VEC9
ADGGFGPWSPWGPCS

SSPOP

3811

A2VEC9
GPWSPWGPCSRSCGG

SSPOP

3816

A2VEC9
EPVTGLPGGWGPWSS

SSPOP

3876

A2VEC9
EGDSDWPGPGGVWGP

SYNE4

221

Q8N205
RGGGPTPWGPAWDAG

PLEKHA4

741

Q9H4M7
PGGWWGCGEPSLGAA

TRIOBP

1456

Q9H2D6
AWGPWGPCSGSCGPG

CILP2

151

Q8IUL8
GWSALPGGSPPGWGQ

TMEM268

21

Q5VZI3
GGRGAQPWGAPWTGP

RGS12

461

O14924
PGPDGGGGTGPWWAA

SARM1

31

Q6SZW1
GPDAGPSGNSSPWWP

AVPR1A

6

P37288
CLAPWWGQQPGGPGP

PRR23C

11

Q6ZRP0
SGSGWGEPWGEPSTP

TNRC6A

1056

Q8NDV7
FCSGPGWDPVTGWGT

TPP1

536

O14773
GWLQGSDCGSPWGPL

LAMC3

1036

Q9Y6N6