Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC6A11 SLC16A1 SLC16A7	2.18e-05	19	58	3	GO:0015355
GeneOntologyMolecularFunction	tau-protein kinase activity	MARK1 MARK4 MARK2	3.44e-05	22	58	3	GO:0050321
GeneOntologyMolecularFunction	NAADP-sensitive calcium-release channel activity	MCOLN1 MCOLN2	8.25e-05	5	58	2	GO:0072345
GeneOntologyMolecularFunction	lactate transmembrane transporter activity	SLC16A1 SLC16A7	1.23e-04	6	58	2	GO:0015129
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ANO4 SLC6A11 CACNG1 KCNA1 TRPM3 SLC16A1 MCOLN1 ANO3 MCOLN2	3.14e-04	758	58	9	GO:0015318
GeneOntologyMolecularFunction	tau protein binding	MARK1 MARK4 MARK2	3.23e-04	46	58	3	GO:0048156
GeneOntologyMolecularFunction	monoatomic ion channel activity	ANO4 CACNG1 KCNA1 TRPM3 MCOLN1 ANO3 MCOLN2	3.54e-04	459	58	7	GO:0005216
GeneOntologyMolecularFunction	gated channel activity	ANO4 CACNG1 KCNA1 MCOLN1 ANO3 MCOLN2	4.08e-04	334	58	6	GO:0022836
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ANO4 SLC6A11 CACNG1 KCNA1 TRPM3 SLC16A1 MCOLN1 ANO3 MCOLN2	4.36e-04	793	58	9	GO:0015075
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO4 ATP8B4 ANO3	4.39e-04	51	58	3	GO:0140303
GeneOntologyMolecularFunction	iron ion transmembrane transporter activity	MCOLN1 MCOLN2	4.48e-04	11	58	2	GO:0005381
GeneOntologyMolecularFunction	dystroglycan binding	CLASP2 DMD	5.37e-04	12	58	2	GO:0002162
GeneOntologyMolecularFunction	calcium channel activity	CACNG1 TRPM3 MCOLN1 MCOLN2	5.38e-04	129	58	4	GO:0005262
GeneOntologyMolecularFunction	channel activity	ANO4 CACNG1 KCNA1 TRPM3 MCOLN1 ANO3 MCOLN2	7.86e-04	525	58	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ANO4 CACNG1 KCNA1 TRPM3 MCOLN1 ANO3 MCOLN2	7.95e-04	526	58	7	GO:0022803
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	ANO4 SLC6A11 MCOLN1 ANO3	9.71e-04	151	58	4	GO:0008509
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNG1 TRPM3 MCOLN1 MCOLN2	9.71e-04	151	58	4	GO:0015085
GeneOntologyMolecularFunction	transporter activity	ANO4 SLC6A11 CACNG1 ATP8B4 KCNA1 TRPM3 SLC16A1 MCOLN1 SLC16A7 ANO3 MCOLN2	1.07e-03	1289	58	11	GO:0005215
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	MCOLN1 MCOLN2	1.23e-03	18	58	2	GO:0015278
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	ANO4 ANO3	1.52e-03	20	58	2	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	ANO4 ANO3	1.52e-03	20	58	2	GO:0005229
GeneOntologyMolecularFunction	transmembrane transporter activity	ANO4 SLC6A11 CACNG1 KCNA1 TRPM3 SLC16A1 MCOLN1 SLC16A7 ANO3 MCOLN2	1.95e-03	1180	58	10	GO:0022857
GeneOntologyMolecularFunction	phospholipid scramblase activity	ANO4 ANO3	2.02e-03	23	58	2	GO:0017128
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A11 CACNG1 KCNA1 TRPM3 SLC16A1 MCOLN1 MCOLN2	2.18e-03	627	58	7	GO:0022890
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A11 CACNG1 KCNA1 TRPM3 MCOLN1 MCOLN2	2.25e-03	465	58	6	GO:0046873
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLC6A11 SLC16A1 SLC16A7	2.28e-03	90	58	3	GO:0008028
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO4 MCOLN1 ANO3 MCOLN2	2.39e-03	193	58	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO4 MCOLN1 ANO3 MCOLN2	2.57e-03	197	58	4	GO:0022834
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A11 CACNG1 KCNA1 TRPM3 SLC16A1 MCOLN1 MCOLN2	3.01e-03	664	58	7	GO:0008324
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNG1 KCNA1 TRPM3 MCOLN1 MCOLN2	3.16e-03	343	58	5	GO:0005261
GeneOntologyMolecularFunction	monoatomic anion channel activity	ANO4 MCOLN1 ANO3	3.35e-03	103	58	3	GO:0005253
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	MCOLN1 MCOLN2	3.65e-03	31	58	2	GO:0099604
GeneOntologyMolecularFunction	protein serine kinase activity	PLK2 CLK1 MARK1 MARK4 MARK2	4.02e-03	363	58	5	GO:0106310
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	MCOLN1 MCOLN2	4.13e-03	33	58	2	GO:0005217
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PLK2 CLK1 MARK1 MARK4 PGM2L1 MARK2 EPHA8	4.31e-03	709	58	7	GO:0016773
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO1G MYO7A DYNC2H1	4.90e-03	118	58	3	GO:0003774
GeneOntologyMolecularFunction	microfilament motor activity	MYO1G MYO7A	5.45e-03	38	58	2	GO:0000146
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PLK2 CLK1 MARK1 MARK4 POLR2K PGM2L1 MARK2 EPHA8	5.49e-03	938	58	8	GO:0016772
GeneOntologyMolecularFunction	magnesium ion binding	PDE2A ATP8B4 MARK1 MARK2	5.75e-03	247	58	4	GO:0000287
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	ANO4 SLC6A11 ANO3	5.75e-03	125	58	3	GO:0015108
GeneOntologyMolecularFunction	kinase activity	PLK2 CLK1 MARK1 MARK4 PGM2L1 MARK2 EPHA8	6.44e-03	764	58	7	GO:0016301
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	MCOLN1 MCOLN2	7.25e-03	44	58	2	GO:0046915
GeneOntologyMolecularFunction	protein kinase activity	PLK2 CLK1 MARK1 MARK4 MARK2 EPHA8	7.73e-03	600	58	6	GO:0004672
GeneOntologyBiologicalProcess	calcium activated phospholipid scrambling	ANO4 ANO3	7.20e-05	5	56	2	GO:0061588
GeneOntologyBiologicalProcess	calcium activated phosphatidylcholine scrambling	ANO4 ANO3	7.20e-05	5	56	2	GO:0061590
GeneOntologyBiologicalProcess	calcium activated galactosylceramide scrambling	ANO4 ANO3	7.20e-05	5	56	2	GO:0061591
GeneOntologyBiologicalProcess	plasma membrane lactate transport	SLC16A1 SLC16A7	1.08e-04	6	56	2	GO:0035879
GeneOntologyBiologicalProcess	pyruvate transmembrane transport	SLC16A1 SLC16A7	1.51e-04	7	56	2	GO:1901475
GeneOntologyCellularComponent	basal cortex	CLASP2 MARK2	1.57e-04	7	58	2	GO:0045180
MousePheno	increased inner cell mass apoptosis	GINS4 MGA	3.31e-05	3	47	2	MP:0012743
Domain	MARK/par1	MARK1 MARK4 MARK2	1.08e-07	4	57	3	IPR033624
Domain	KA1_dom	MARK1 MARK4 MARK2	2.68e-07	5	57	3	IPR001772
Domain	KA1	MARK1 MARK4 MARK2	2.68e-07	5	57	3	PF02149
Domain	KA1	MARK1 MARK4 MARK2	2.68e-07	5	57	3	PS50032
Domain	-	MARK1 MARK4 MARK2	2.68e-07	5	57	3	3.30.310.80
Domain	KA1/Ssp2_C	MARK1 MARK4 MARK2	9.35e-07	7	57	3	IPR028375
Domain	Ribosomal_L10e_CS	RPL10L RPL10	9.15e-06	2	57	2	IPR018255
Domain	Ribosomal_L10e	RPL10L RPL10	9.15e-06	2	57	2	IPR001197
Domain	RIBOSOMAL_L10E	RPL10L RPL10	9.15e-06	2	57	2	PS01257
Domain	Ribosomal_L10e/L16	RPL10L RPL10	2.74e-05	3	57	2	IPR016180
Domain	-	RPL10L RPL10	2.74e-05	3	57	2	3.90.1170.10
Domain	Ribosomal_L16	RPL10L RPL10	2.74e-05	3	57	2	PF00252
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	PLK2 MARK1 MARK4 MARK2	5.81e-05	69	57	4	IPR020636
Domain	MCT	SLC16A1 SLC16A7	9.10e-05	5	57	2	IPR004743
Domain	UBA	MARK1 MARK4 MARK2	1.03e-04	30	57	3	SM00165
Domain	UBA	MARK1 MARK4 MARK2	1.79e-04	36	57	3	PF00627
Domain	Anoct_dimer	ANO4 ANO3	1.90e-04	7	57	2	PF16178
Domain	Anoct_dimer	ANO4 ANO3	1.90e-04	7	57	2	IPR032394
Domain	UBA	MARK1 MARK4 MARK2	3.27e-04	44	57	3	IPR015940
Domain	UBA	MARK1 MARK4 MARK2	3.97e-04	47	57	3	PS50030
Domain	Ion_trans_dom	KCNA1 TRPM3 MCOLN1 MCOLN2	4.05e-04	114	57	4	IPR005821
Domain	Ion_trans	KCNA1 TRPM3 MCOLN1 MCOLN2	4.05e-04	114	57	4	PF00520
Domain	Anoctamin	ANO4 ANO3	4.05e-04	10	57	2	PF04547
Domain	Anoctamin	ANO4 ANO3	4.05e-04	10	57	2	IPR007632
Domain	PKD_channel	MCOLN1 MCOLN2	4.94e-04	11	57	2	PF08016
Domain	PKD1_2_channel	MCOLN1 MCOLN2	4.94e-04	11	57	2	IPR013122
Domain	Protein_kinase_ATP_BS	PLK2 CLK1 MARK1 MARK4 MARK2 EPHA8	1.02e-03	379	57	6	IPR017441
Domain	Kinase-like_dom	PLK2 CLK1 MARK1 MARK4 MARK2 DMD EPHA8	1.25e-03	542	57	7	IPR011009
Domain	PROTEIN_KINASE_ATP	PLK2 CLK1 MARK1 MARK4 MARK2 EPHA8	2.68e-03	459	57	6	PS00107
Domain	Prot_kinase_dom	PLK2 CLK1 MARK1 MARK4 MARK2 EPHA8	3.66e-03	489	57	6	IPR000719
Domain	PROTEIN_KINASE_DOM	PLK2 CLK1 MARK1 MARK4 MARK2 EPHA8	3.81e-03	493	57	6	PS50011
Domain	Ser/Thr_kinase_AS	PLK2 CLK1 MARK1 MARK4 MARK2	4.60e-03	357	57	5	IPR008271
Domain	S_TKc	PLK2 CLK1 MARK1 MARK4 MARK2	4.71e-03	359	57	5	SM00220
Domain	PROTEIN_KINASE_ST	PLK2 CLK1 MARK1 MARK4 MARK2	4.88e-03	362	57	5	PS00108
Domain	Myosin_head_motor_dom	MYO1G MYO7A	6.00e-03	38	57	2	IPR001609
Domain	MYOSIN_MOTOR	MYO1G MYO7A	6.00e-03	38	57	2	PS51456
Domain	Myosin_head	MYO1G MYO7A	6.00e-03	38	57	2	PF00063
Domain	MYSc	MYO1G MYO7A	6.00e-03	38	57	2	SM00242
Domain	Pkinase	PLK2 CLK1 MARK1 MARK4 MARK2	6.04e-03	381	57	5	PF00069
Domain	Peptidase_M12B_N	ADAMTS7 ADAM30	6.31e-03	39	57	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS7 ADAM30	6.31e-03	39	57	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS7 ADAM30	6.63e-03	40	57	2	PS00427
Domain	Reprolysin	ADAMTS7 ADAM30	6.63e-03	40	57	2	PF01421
Domain	ADAM_MEPRO	ADAMTS7 ADAM30	6.63e-03	40	57	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS7 ADAM30	6.63e-03	40	57	2	PS50214
Domain	Peptidase_M12B	ADAMTS7 ADAM30	6.63e-03	40	57	2	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS7 ADAM30	6.95e-03	41	57	2	PS00546
Domain	Disintegrin_dom	ADAMTS7 ADAM30	6.95e-03	41	57	2	IPR001762
Domain	Pept_M10_metallopeptidase	ADAMTS7 ADAM30	7.63e-03	43	57	2	IPR001818
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO4 TRPM3 MCOLN1 ANO3 MCOLN2	2.08e-05	99	48	5	MM14910
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ANO4 ATP8B4 TRPM3 MCOLN1 ANO3 MCOLN2	2.76e-05	176	48	6	MM15718
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO4 TRPM3 MCOLN1 ANO3 MCOLN2	2.89e-05	106	48	5	M27200
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ANO4 ATP8B4 TRPM3 MCOLN1 ANO3 MCOLN2	3.44e-05	183	48	6	M997
Pathway	REACTOME_TRP_CHANNELS	TRPM3 MCOLN1 MCOLN2	1.14e-04	28	48	3	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPM3 MCOLN1 MCOLN2	1.14e-04	28	48	3	M27241
Pathway	REACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT	SLC16A1 SLC16A7	1.69e-04	6	48	2	MM17217
Pathway	REACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT	SLC16A1 SLC16A7	1.69e-04	6	48	2	M27355
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ANO4 SLC6A11 ATP8B4 TRPM3 SLC16A1 MCOLN1 SLC16A7 ANO3 MCOLN2	4.19e-04	681	48	9	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ANO4 SLC6A11 ATP8B4 TRPM3 SLC16A1 MCOLN1 SLC16A7 ANO3 MCOLN2	7.35e-04	736	48	9	M27287
Pathway	WP_LACTATE_SHUTTLE_IN_GLIAL_CELLS	SLC16A1 SLC16A7	8.65e-04	13	48	2	M48056
Pathway	REACTOME_INDUCTION_OF_CELL_CELL_FUSION	ANO4 ANO3	8.65e-04	13	48	2	M46426
Pubmed	MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.	MARK1 MARK4 MARK2	4.64e-09	3	59	3	9108484
Pubmed	Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.	MARK1 MARK4 MARK2	9.24e-08	6	59	3	23666762
Pubmed	LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.	MARK1 MARK4 MARK2	2.08e-06	15	59	3	14976552
Pubmed	The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.	DMD MCOLN1	2.83e-06	2	59	2	25216637
Pubmed	Monocarboxylate transporter expression in mouse brain.	SLC16A1 SLC16A7	2.83e-06	2	59	2	9725820
Pubmed	Polymorphisms of monocarboxylate transporter genes are associated with clinical outcomes in patients with colorectal cancer.	SLC16A1 SLC16A7	2.83e-06	2	59	2	25492048
Pubmed	The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1.	MCOLN1 MCOLN2	2.83e-06	2	59	2	19763610
Pubmed	Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes.	SLC16A1 SLC16A7	2.83e-06	2	59	2	15505343
Pubmed	MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway.	MARK4 MARK2	2.83e-06	2	59	2	35192892
Pubmed	The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.	MCOLN1 MCOLN2	2.83e-06	2	59	2	18794901
Pubmed	Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.	SLC16A1 SLC16A7	2.83e-06	2	59	2	36814318
Pubmed	Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.	MARK1 MARK2	2.83e-06	2	59	2	16803889
Pubmed	Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures.	SLC16A1 SLC16A7	2.83e-06	2	59	2	12836157
Pubmed	Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain.	SLC16A1 SLC16A7	2.83e-06	2	59	2	9520480
Pubmed	The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b.	MARK2 DMD	8.48e-06	3	59	2	19945424
Pubmed	Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1.	MCOLN1 MCOLN2	8.48e-06	3	59	2	16606612
Pubmed	Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.	SLC16A1 SLC16A7	8.48e-06	3	59	2	18188595
Pubmed	Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy.	MCOLN1 MCOLN2	8.48e-06	3	59	2	20736310
Pubmed	Basigin interacts with both MCT1 and MCT2 in murine spermatozoa.	SLC16A1 SLC16A7	8.48e-06	3	59	2	21792931
Pubmed	Genetic variations in monocarboxylate transporter genes as predictors of clinical outcomes in non-small cell lung cancer.	SLC16A1 SLC16A7	8.48e-06	3	59	2	25578492
Pubmed	PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles.	CLASP2 MARK2	8.48e-06	3	59	2	16123238
Pubmed	Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.	SLC16A1 SLC16A7	8.48e-06	3	59	2	32819565
Pubmed	Functional multimerization of mucolipin channel proteins.	MCOLN1 MCOLN2	8.48e-06	3	59	2	19885840
Pubmed	Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.	SLC16A1 SLC16A7	8.48e-06	3	59	2	17599960
Pubmed	Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT family in the mouse kidney.	SLC16A1 SLC16A7	8.48e-06	3	59	2	18751721
Pubmed	Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.	SLC16A1 SLC16A7	8.48e-06	3	59	2	19876643
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM3 MCOLN1 MCOLN2	1.04e-05	25	59	3	16382100
Pubmed	An introduction to TRP channels.	TRPM3 MCOLN1 MCOLN2	1.32e-05	27	59	3	16460286
Pubmed	Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.	MCOLN1 MCOLN2	1.69e-05	4	59	2	30479274
Pubmed	Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.	MARK1 MARK2	1.69e-05	4	59	2	10542369
Pubmed	Monocarboxylate transport in human corneal epithelium and cell lines.	SLC16A1 SLC16A7	1.69e-05	4	59	2	20035863
Pubmed	FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.	ANO4 ANO3	1.69e-05	4	59	2	12739008
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	MARK1 MARK4 MARK2	1.82e-05	30	59	3	16306228
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	MARK1 MARK4 MARK2	2.02e-05	31	59	3	31636950
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM3 MCOLN1 MCOLN2	2.44e-05	33	59	3	19834762
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PDE2A UBA1 KCNA1 MYO7A MARK1 SNX27 TOLLIP CLASP2 MARK2 DMD RPL10	2.50e-05	1431	59	11	37142655
Pubmed	Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44.	SLC16A1 SLC16A7	2.82e-05	5	59	2	20454640
Pubmed	Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development.	SLC16A1 SLC16A7	2.82e-05	5	59	2	12056458
Pubmed	Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors.	SLC16A1 SLC16A7	2.82e-05	5	59	2	33999492
Pubmed	Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture.	SLC16A1 SLC16A7	2.82e-05	5	59	2	39013907
Pubmed	Mucolipin co-deficiency causes accelerated endolysosomal vacuolation of enterocytes and failure-to-thrive from birth to weaning.	MCOLN1 MCOLN2	2.82e-05	5	59	2	25521295
Pubmed	Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.	SLC16A1 SLC16A7	2.82e-05	5	59	2	21787388
Pubmed	Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).	SLC16A1 SLC16A7	4.23e-05	6	59	2	15917240
Pubmed	Identification and characterization of TMEM16E and TMEM16F genes in silico.	ANO4 ANO3	4.23e-05	6	59	2	15067359
Pubmed	Roles of tau protein in health and disease.	MARK1 MARK4 MARK2	4.38e-05	40	59	3	28386764
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	KCNA1 ADAMTS7 LONRF1 OAZ3	4.64e-05	116	59	4	30652415
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM3 MCOLN1 MCOLN2	5.84e-05	44	59	3	19322198
Pubmed	Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis.	SLC16A1 SLC16A7	5.91e-05	7	59	2	20392797
Pubmed	Cited2 is required in trophoblasts for correct placental capillary patterning.	SLC16A1 SLC16A7	7.87e-05	8	59	2	24803182
Pubmed	Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.	MARK1 MARK2	7.87e-05	8	59	2	22298430
Pubmed	High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial.	GP6 MARK2	7.87e-05	8	59	2	19530321
Pubmed	Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination.	SLC16A1 SLC16A7	7.87e-05	8	59	2	25762662
Pubmed	A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1.	UBA1 DMD	7.87e-05	8	59	2	1749428
Pubmed	Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture.	HOXD13 DMD	7.87e-05	8	59	2	33304744
Pubmed	Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution.	UBA1 DMD	1.01e-04	9	59	2	9736774
Pubmed	Genetics of dizziness: cerebellar and vestibular disorders.	KCNA1 MYO7A	1.01e-04	9	59	2	24275721
Pubmed	Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.	MAGEB6 DMD	1.01e-04	9	59	2	7590750
Pubmed	Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.	ANO4 ANO3	1.26e-04	10	59	2	19015192
Pubmed	Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.	ANO4 ANO3	1.26e-04	10	59	2	23532839
Pubmed	Structure and function of TMEM16 proteins (anoctamins).	ANO4 ANO3	1.26e-04	10	59	2	24692353
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	SLC16A1 OBP2A MARK4 PGM2L1 CLASP2 TAAR1 MCOLN1	1.74e-04	697	59	7	28298427
Pubmed	The glucose-lactic acid cycle and gluconeogenesis.	SLC16A1 SLC16A7	1.85e-04	12	59	2	7273846
Pubmed	ILDR2 stabilization is regulated by its interaction with GRP78.	MYO1G PPP1R36	1.85e-04	12	59	2	33863978
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ATP8B4 TRPM3 DYNC2H1 MARK1 PRORP MGA	1.88e-04	493	59	6	15368895
Pubmed	Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.	MARK1 MARK4 MARK2	2.15e-04	68	59	3	14676191
Pubmed	A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.	UBA1 DMD	2.18e-04	13	59	2	8625802
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	MYO1G UBA1 DYNC2H1 MARK2 DMD	2.19e-04	322	59	5	26514267
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	PLK2 UBA1 TRPM3 CLK1 MARK1 ADAM30 MARK2	2.31e-04	730	59	7	34857952
Pubmed	The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.	SLC16A1 SLC16A7	2.54e-04	14	59	2	12739169
Pubmed	A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.	POLR2K TAAR1	2.93e-04	15	59	2	9491887
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	MARK1 MARK4 MARK2	3.22e-04	78	59	3	17192257
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	SLC16A1 PATZ1 PHF6 CLASP2 MGA RPL10	3.27e-04	547	59	6	37267103
Pubmed	MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.	MARK1 MARK4	3.34e-04	16	59	2	14594945
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	RPL10L UBA1 SLC16A1 PATZ1 PHF6 RPL10	3.89e-04	565	59	6	33567341
Pubmed	HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.	UBA1 FBXO4 ANAPC2	4.91e-04	90	59	3	35671810
Pubmed	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.	MARK1 MARK2	5.27e-04	20	59	2	18227155
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	UBA1 ATP8B4 SLC16A1 UTP15 DYNC2H1 PHF6 CLASP2 RPL10 MCOLN2	6.28e-04	1425	59	9	30948266
Pubmed	Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.	MARK2 EPHA8	6.39e-04	22	59	2	22305495
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	MARK1 CLASP2 MARK2 RPL10	6.48e-04	231	59	4	16452087
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MYO7A DYNC2H1 SMARCB1 PHF6 ADAM30 MORC4	7.35e-04	638	59	6	31182584
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	UBA1 CLASP2 MGA RPL10	9.50e-04	256	59	4	32698014
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	PLK2 UBA1 SLC16A1 MGA	1.17e-03	271	59	4	25737280
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	MARK1 ANAPC2 PHF6 MORC4	1.34e-03	281	59	4	24163370
Pubmed	RNA binding proteins co-localize with small tau inclusions in tauopathy.	SLC6A11 PDE2A UBA1 SLC16A1	1.37e-03	283	59	4	30068389
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	SLC16A1 DYNC2H1 MARK1 MARK2 RPL10	1.47e-03	491	59	5	36273042
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	MARK1 MARK4 MARK2	1.49e-03	132	59	3	16944949
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	FBXO4 SESN2 MORC4 MGA RPL10	1.52e-03	495	59	5	27705803
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MYO7A SMARCB1 CLASP2 MARK2 ANO3	1.55e-03	497	59	5	36774506
Cytoband	1p12	SLC16A1 ADAM30	4.78e-04	25	59	2	1p12
GeneFamily	Transient receptor potential cation channels	TRPM3 MCOLN1 MCOLN2	4.22e-05	28	44	3	249
GeneFamily	Anoctamins	ANO4 ANO3	2.57e-04	10	44	2	865
Disease	visual impairment and progressive phthisis bulbi (implicated_via_orthology)	MARK1 MARK4 MARK2	2.73e-08	4	57	3	DOID:0070356 (implicated_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	MARK1 MARK4 TOLLIP PNPLA7 MARK2	9.11e-06	145	57	5	DOID:1289 (implicated_via_orthology)
Disease	mucolipidosis type IV (implicated_via_orthology)	MCOLN1 MCOLN2	1.10e-05	3	57	2	DOID:0080490 (implicated_via_orthology)
Disease	T-cell acute lymphoblastic leukemia (implicated_via_orthology)	RPL10L RPL10	1.10e-05	3	57	2	DOID:5603 (implicated_via_orthology)
Disease	autistic disorder (implicated_via_orthology)	RPL10L RPL10	2.19e-05	4	57	2	DOID:12849 (implicated_via_orthology)
Disease	glycoproteinosis (implicated_via_orthology)	MCOLN1 MCOLN2	2.19e-05	4	57	2	DOID:3343 (implicated_via_orthology)
Disease	spondyloepiphyseal dysplasia congenita (implicated_via_orthology)	RPL10L RPL10	5.47e-05	6	57	2	DOID:14789 (implicated_via_orthology)
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	RPL10L RPL10	7.65e-05	7	57	2	DOID:0060807 (implicated_via_orthology)
Disease	Coffin-Siris syndrome	SMARCB1 PHF6	2.82e-04	13	57	2	C0265338
Disease	Generalized hypotonia	TRPM3 SNX27	3.79e-04	15	57	2	C1858120
Disease	FEV change measurement, response to zileuton	PRORP SLC16A7	1.07e-03	25	57	2	EFO_0005921, EFO_0007676
Disease	PCSK9 protein measurement	KCNA1 PRORP	1.16e-03	26	57	2	EFO_0006899
Disease	immature platelet measurement	MYO1G TRPM3 MARK4	1.60e-03	119	57	3	EFO_0803541

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYGCFLRVYMQSKRK	ANAPC2	176	Q9UJX6
AVYRMCCPYTRRASK	FBXO4	141	Q9UKT5
RKMYYSRKAIPAVAR	ATP8B4	361	Q8TF62
RTKRYFAKHPRMGYL	DMD	3381	P11532
RRKIYYLPRRYKFMS	ANO4	186	Q32M45
YLPRRYKFMSRIDKQ	ANO4	191	Q32M45
KYKGRYCVGERKRFR	ADAMTS7	571	Q9UKP4
IRMPFRKKCYYTDGR	ANO3	226	Q9BYT9
KKRDYLLRPASMFYA	CACNG1	131	Q06432
GRYVSRRCKPLKEFM	CLK1	426	P49759
KPVSCRAAYRKYMTV	INSYN2A	76	Q6ZSG2
LRRRLKYFFMSPCDK	MCOLN1	41	Q9GZU1
ALTMIGKYFYKRRPL	SLC16A1	131	P53985
YRITLREKMLPRCYK	OAZ3	41	Q9UMX2
PKKRMRYFDPLRNEY	KCNA1	66	Q09470
MLKCVRREYKPYFPQ	MAGEB6	221	Q8N7X4
ILTKQGRRMFPYCRY	MGA	96	Q8IWI9
RFRVLKRGMKDGYCT	LONRF1	646	Q17RB8
DMKRRVGPYRRCYFF	MLYCD	226	O95822
PAMKRSLAGRYRCSY	GP6	76	Q9HCN6
CRRYMEDLKKICFYR	PGM2L1	236	Q6PCE3
RFCLMVKKGYRDPPY	PDE2A	641	O00408
ALTIIGKYFYRKRPM	SLC16A7	131	O60669
RLGCAPRFKDFQRMY	METRNL	281	Q641Q3
VFYCKDQRRGGLRYM	OBP2A	111	Q9NY56
PQYRFRKRDKVMFYG	PNPLA7	46	Q6ZV29
PVCGLRFKRKDRMSY	PATZ1	386	Q9HBE1
GCKMYYSRRGIRYRT	TMEM123	186	Q8N131
RAKYYREMKRFIGIP	DYNC2H1	796	Q8NCM8
YEGRCFRKGCRSRYM	ADAM30	491	Q9UKF2
GRMLSYKYRSKPACA	C3orf49	91	Q96BT1
SLRIYYKKCPAMVRN	EPHA8	196	P29322
CVYRRGRKKRVPYTK	HOXD13	271	P35453
RERVLRGKYRIPFYM	MARK1	266	Q9P0L2
RVLRGKYRIPFYMST	MARK2	261	Q7KZI7
ERVLRGKYRVPFYMS	MARK4	266	Q96L34
KFYFMSPCEKYRARR	MCOLN2	46	Q8IZK6
MGRRPARCYRYCKNK	RPL10L	1	Q96L21
KTVACYPEKTTRRMY	SESN2	426	P58004
RRPAYRTFIKGKNYM	UTP15	331	Q8TED0
SYLRCRLMKIEKFFP	GINS4	91	Q9BRT9
MGRRPARCYRYCKNK	RPL10	1	P27635
YSLRAFCGILYMKPR	MORC4	266	Q8TE76
LRMFRGSLYKRYPSL	SMARCB1	36	Q12824
MKARYKTLEPRGYSL	PRORP	201	O15091
LKKPARRRYESYGMH	CLASP2	606	O75122
REKPSQGIYMVYCRK	PHF6	116	Q8IWS0
MGGAYRCNYTRKRFR	TRPM3	591	Q9HCF6
KNYGMTRMDPYCRLR	TOLLIP	66	Q9H0E2
AVVDMYPKVFRRGYR	SLC6A11	421	P48066
YMAGRQLCSKRYREF	SNX27	186	Q96L92
MYRVPEFYARRKRLG	PPP1R36	1	Q96LQ0
CRECGYRIMYKKRTK	POLR2K	36	P53803
RYYAVCDPLRYKAKM	TAAR1	121	Q96RJ0
RMYMDRRCVYYRKPL	UBA1	581	P22314
KETYRCIREARYTMP	PLK2	286	Q9NYY3
KRYPKNCLLTVMDRY	THRSP	6	Q92748
KECGKAFMCPRYVRR	ZNF439	301	Q8NDP4
RQPYSRFLLRYKMTC	MYO1G	641	B0I1T2
AVLKYMGDYPSKRTR	MYO7A	1776	Q13402