Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

TRPC4AP SLC52A1 TMEM241 PIEZO1 SLC38A5 XKR8 GRIA2 KCNK12 TMEM87A MFSD14A SLC41A2 GJA8 NALCN TSPO2 KCNJ5 KCNJ11 KCNN4 DISP2 TRPM8 ATG9A SLC38A3 SLC23A3

7.61e-07128910522GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

TRPC4AP SLC52A1 TMEM241 PIEZO1 SLC38A5 GRIA2 KCNK12 TMEM87A MFSD14A SLC41A2 GJA8 NALCN TSPO2 KCNJ5 KCNJ11 KCNN4 DISP2 TRPM8 SLC38A3 SLC23A3

2.95e-06118010520GO:0022857
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPC4AP SLC38A5 GRIA2 KCNK12 TMEM87A SLC41A2 NALCN KCNJ5 KCNJ11 KCNN4 TRPM8 SLC38A3

6.07e-0646510512GO:0046873
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPC4AP PIEZO1 GRIA2 KCNK12 TMEM87A NALCN KCNJ5 KCNJ11 KCNN4 TRPM8

1.33e-0534310510GO:0005261
GeneOntologyMolecularFunctionL-glutamine, sodium:proton antiporter activity

SLC38A5 SLC38A3

2.74e-0521052GO:0140830
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TRPC4AP PIEZO1 SLC38A5 GRIA2 KCNK12 TMEM87A SLC41A2 NALCN KCNJ5 KCNJ11 KCNN4 TRPM8 SLC38A3

4.55e-0566410513GO:0008324
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR51T1 GPR182 OR52L1 C5AR2 OR2T1 BDKRB1 GPR179 CXCR5 GPR146 CCR2 ADGRG7 OR4C3 OR52L2P SMO GP1BA

5.88e-0588410515GO:0004930
GeneOntologyMolecularFunctionpotassium channel activity

GRIA2 KCNK12 TMEM87A KCNJ5 KCNJ11 KCNN4

5.91e-051281056GO:0005267
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR51T1 GPR182 OR52L1 C5AR2 OR2T1 GRIA2 BDKRB1 GPR179 GHR CXCR5 GPR146 CCR2 ADGRG7 OR4C3 FCGR1A OR52L2P FCRLB SMO GP1BA

7.36e-05135310519GO:0004888
GeneOntologyMolecularFunctionchannel activity

TRPC4AP PIEZO1 GRIA2 KCNK12 TMEM87A GJA8 NALCN KCNJ5 KCNJ11 KCNN4 TRPM8

1.00e-0452510511GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

TRPC4AP PIEZO1 GRIA2 KCNK12 TMEM87A GJA8 NALCN KCNJ5 KCNJ11 KCNN4 TRPM8

1.02e-0452610511GO:0022803
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TRPC4AP SLC38A5 GRIA2 KCNK12 TMEM87A SLC41A2 NALCN KCNJ5 KCNJ11 KCNN4 TRPM8 SLC38A3

1.13e-0462710512GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TRPC4AP PIEZO1 GRIA2 KCNK12 TMEM87A NALCN KCNJ5 KCNJ11 KCNN4 TRPM8

1.54e-0445910510GO:0005216
GeneOntologyMolecularFunctionL-asparagine transmembrane transporter activity

SLC38A5 SLC38A3

1.63e-0441052GO:0015182
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

GRIA2 KCNK12 TMEM87A KCNJ5 KCNJ11 KCNN4

2.54e-041671056GO:0015079
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

TRPC4AP PIEZO1 SLC38A5 GRIA2 KCNK12 TMEM87A SLC41A2 NALCN KCNJ5 KCNJ11 KCNN4 TRPM8 SLC38A3

2.66e-0479310513GO:0015075
GeneOntologyMolecularFunctionL-histidine transmembrane transporter activity

SLC38A5 SLC38A3

2.71e-0451052GO:0005290
GeneOntologyMolecularFunctionamino acid:monoatomic cation antiporter activity

SLC38A5 SLC38A3

2.71e-0451052GO:0140848
GeneOntologyMolecularFunctiongated channel activity

PIEZO1 GRIA2 KCNK12 TMEM87A KCNJ5 KCNJ11 KCNN4 TRPM8

3.85e-043341058GO:0022836
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNJ5 KCNJ11 KCNN4

4.21e-04281053GO:0005242
GeneOntologyMolecularFunctionmechanosensitive monoatomic cation channel activity

PIEZO1 TMEM87A

5.65e-0471052GO:0140135
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

TRPC4AP SLC38A5 GRIA2 KCNK12 TMEM87A SLC41A2 NALCN KCNJ5 KCNJ11 KCNN4 TRPM8 SLC38A3

6.32e-0475810512GO:0015318
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

GRIA2 KCNJ5 KCNJ11 KCNN4 TRPM8

8.68e-041401055GO:0099094
GeneOntologyMolecularFunctionL-glutamine transmembrane transporter activity

SLC38A5 SLC38A3

9.63e-0491052GO:0015186
GeneOntologyMolecularFunctionimmune receptor activity

C5AR2 GHR CXCR5 CCR2 FCGR1A

1.80e-031651055GO:0140375
GeneOntologyMolecularFunctionaromatic amino acid transmembrane transporter activity

SLC38A5 SLC38A3

2.06e-03131052GO:0015173
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNK12 KCNJ5 KCNJ11 KCNN4

2.07e-031021054GO:0005249
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC38A5 GRIA2 TSPO2 SLC38A3

2.30e-031051054GO:0015171
GeneOntologyMolecularFunctionazole transmembrane transporter activity

SLC38A5 SLC38A3

2.39e-03141052GO:1901474
GeneOntologyMolecularFunctionsodium:proton antiporter activity

SLC38A5 SLC38A3

3.13e-03161052GO:0015385
GeneOntologyMolecularFunctionalanine transmembrane transporter activity

SLC38A5 SLC38A3

3.13e-03161052GO:0022858
GeneOntologyMolecularFunctionoxysterol binding

SMO TMEM97

3.13e-03161052GO:0008142
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GRIA2 KCNJ5 KCNJ11 KCNN4 TRPM8

3.55e-031931055GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GRIA2 KCNJ5 KCNJ11 KCNN4 TRPM8

3.87e-031971055GO:0022834
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

PIEZO1 TMEM87A

3.97e-03181052GO:0008381
GeneOntologyMolecularFunctionnarrow pore channel activity

KCNK12 NALCN

4.42e-03191052GO:0022842
GeneOntologyMolecularFunctionleak channel activity

KCNK12 NALCN

4.42e-03191052GO:0022840
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC52A1 TMEM241 SLC38A5 GRIA2 TSPO2 SLC38A3

4.54e-032931056GO:0008514
GeneOntologyMolecularFunctionbasic amino acid transmembrane transporter activity

SLC38A5 SLC38A3

4.89e-03201052GO:0015174
GeneOntologyCellularComponentexternal side of plasma membrane

ADAM20 CEACAM4 GRIA2 GHR CXCR5 CCR2 FCGR1A KCNJ5 FCRLB TRPM8 GP1BA

6.59e-0551910611GO:0009897
GeneOntologyCellularComponentendoplasmic reticulum membrane

CYP2J2 PIEZO1 PIGU ALG10B PTPN5 ACSL4 NBAS ZDHHC12 ORMDL3 BSG TSPO2 NUS1 SYNE2 TRPM8 TMEM97 ATG9A HSD17B3

2.65e-04129310617GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

CYP2J2 PIEZO1 PIGU ALG10B PTPN5 ACSL4 NBAS ZDHHC12 ORMDL3 BSG TSPO2 NUS1 SYNE2 TRPM8 TMEM97 ATG9A HSD17B3

2.79e-04129910617GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

CYP2J2 PIEZO1 PIGU ALG10B PTPN5 ACSL4 NBAS ZDHHC12 ORMDL3 BSG TSPO2 NUS1 SYNE2 TRPM8 TMEM97 ATG9A HSD17B3

3.58e-04132710617GO:0042175
GeneOntologyCellularComponentside of membrane

TRAF6 ADAM20 CEACAM4 GRIA2 ALG10B GHR CXCR5 CCR2 FCGR1A KCNJ5 FCRLB TRPM8 GP1BA

4.83e-0487510613GO:0098552
GeneOntologyCellularComponentleading edge membrane

PIEZO1 GRIA2 KCNJ11 SYNE2 MACF1 CLRN2

7.09e-042101066GO:0031256
DomainGPR107-like

GPR108 TMEM87A

1.79e-0441032IPR009637
DomainBNIP2

PRUNE2 BNIP2

1.79e-0441032PF12496
DomainLung_7-TM_R

GPR108 TMEM87A

1.79e-0441032PF06814
DomainBcl2-/adenovirus-E1B

PRUNE2 BNIP2

1.79e-0441032IPR022181
DomainActinin_actin-bd_CS

SYNE2 MACF1 PLEC

2.66e-04231033IPR001589
DomainACTININ_2

SYNE2 MACF1 PLEC

2.66e-04231033PS00020
DomainACTININ_1

SYNE2 MACF1 PLEC

2.66e-04231033PS00019
Domain-

MACF1 PLEC

4.45e-04610323.90.1290.10
DomainSpectrin_repeat

SYNE2 MACF1 PLEC

5.36e-04291033IPR002017
DomainPlectin_repeat

MACF1 PLEC

6.21e-0471032IPR001101
DomainPlectin

MACF1 PLEC

6.21e-0471032PF00681
DomainPLEC

MACF1 PLEC

6.21e-0471032SM00250
DomainSpectrin/alpha-actinin

SYNE2 MACF1 PLEC

7.19e-04321033IPR018159
DomainSPEC

SYNE2 MACF1 PLEC

7.19e-04321033SM00150
DomainNXPH/NXPE

NXPE4 NXPE1

8.25e-0481032IPR026845
DomainNeurexophilin

NXPE4 NXPE1

8.25e-0481032PF06312
DomainXK_rel

XKR8 XKR3

1.60e-03111032IPR018629
DomainXK-related

XKR8 XKR3

1.60e-03111032PF09815
DomainCRAL_TRIO_2

PRUNE2 BNIP2

1.92e-03121032PF13716
DomainSSD

PTCHD4 DISP2

2.26e-03131032IPR000731
DomainSSD

PTCHD4 DISP2

2.26e-03131032PS50156
DomainIg_E-set

NXPE4 NXPE1 KCNJ5 KCNJ11

2.63e-031041034IPR014756
DomainK_chnl_inward-rec_Kir_cyto

KCNJ5 KCNJ11

3.44e-03161032IPR013518
DomainIRK

KCNJ5 KCNJ11

3.44e-03161032PF01007
Domain-

KCNJ5 KCNJ11

3.44e-031610322.60.40.1400
DomainK_chnl_inward-rec_Kir

KCNJ5 KCNJ11

3.44e-03161032IPR016449
DomainAa_trans

SLC38A5 SLC38A3

3.88e-03171032PF01490
DomainAA_transpt_TM

SLC38A5 SLC38A3

3.88e-03171032IPR013057
DomainGPCR_Rhodpsn_7TM

OR51T1 GPR182 OR52L1 C5AR2 OR2T1 BDKRB1 CXCR5 GPR146 CCR2 OR4C3

3.89e-0367010310IPR017452
Domain7tm_1

OR51T1 GPR182 OR52L1 C5AR2 OR2T1 BDKRB1 CXCR5 GPR146 CCR2 OR4C3

4.18e-0367710310PF00001
DomainG_PROTEIN_RECEP_F1_1

OR51T1 GPR182 OR52L1 C5AR2 OR2T1 BDKRB1 CXCR5 GPR146 CCR2 OR4C3

4.54e-0368510310PS00237
DomainG_PROTEIN_RECEP_F1_2

OR51T1 GPR182 OR52L1 C5AR2 OR2T1 BDKRB1 CXCR5 GPR146 CCR2 OR4C3

4.82e-0369110310PS50262
DomainGPCR_Rhodpsn

OR51T1 GPR182 OR52L1 C5AR2 OR2T1 BDKRB1 CXCR5 GPR146 CCR2 OR4C3

4.87e-0369210310IPR000276
DomainIGFBP-like

ESM1 HTRA4

5.36e-03201032IPR000867
DomainIGFBP

ESM1 HTRA4

5.36e-03201032PF00219
DomainIGFBP_N_2

ESM1 HTRA4

5.36e-03201032PS51323
Pubmed

Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells.

SLC38A5 SLC38A3

9.20e-062106216249471
Pubmed

Smoothened stabilizes and protects TRAF6 from degradation: A novel non-canonical role of smoothened with implications in lymphoma biology.

TRAF6 SMO

9.20e-062106230165192
Pubmed

A structural perspective on the interactions of TRAF6 and Basigin during the onset of melanoma: A molecular dynamics simulation study.

TRAF6 BSG

9.20e-062106228612997
Pubmed

Cleavage of BNIP-2 and BNIP-XL by caspases.

PRUNE2 BNIP2

9.20e-062106217961507
Pubmed

Clinical and biological features in PIEZO1-hereditary xerocytosis and Gardos channelopathy: a retrospective series of 126 patients.

PIEZO1 KCNN4

9.20e-062106230655378
Pubmed

The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells.

PIEZO1 KCNN4

9.20e-062106238338693
Pubmed

Red blood cell Gardos channel (KCNN4): the essential determinant of erythrocyte dehydration in hereditary xerocytosis.

PIEZO1 KCNN4

9.20e-062106228619848
Pubmed

The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes.

XKR8 BSG

9.20e-062106234625749
Pubmed

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.

SLC38A5 SLC38A3

9.20e-062106218689705
Pubmed

EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.

BSG MMP1

9.20e-062106210706100
Pubmed

Interstitial collagenase MMP-1 and EMMPRIN in cell lines and in clinical specimens of cervical squamous cell carcinoma.

BSG MMP1

9.20e-062106234495460
Pubmed

TRAF6 regulates melanoma invasion and metastasis through ubiquitination of Basigin.

TRAF6 BSG

9.20e-062106226769849
Pubmed

Systematic identification of pathological lamin A interactors.

GPR108 SLC41A2 ADGRG7 ORMDL3 BNIP2 CSGALNACT2 NALCN CMTM7

9.46e-06337106824623722
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

GPR182 LAPTM4B C5AR2 PIGU BDKRB1 GPR146 CCR2 MFSD14A BSG KCNJ5 SMO

9.60e-066971061128298427
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

CARMIL3 TM9SF1 PIEZO1 PIGU TMEM87A ACSL4 BSG TMEM245 TIMM50

2.30e-05499106922810586
Pubmed

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.

KCNJ5 KCNJ11

2.76e-053106231909710
Pubmed

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.

XKR8 BSG

2.76e-053106227503893
Pubmed

Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering.

BSG MMP1

2.76e-053106214707126
Pubmed

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

LAPTM4B HTRA4 GALNT7 PIGU TMEM87A MFSD14A ZDHHC12 ORMDL3

5.36e-05430106816303743
Pubmed

CD147, MMP-1, MMP-2 and MMP-9 protein expression as significant prognostic factors in human prostate cancer.

BSG MMP1

5.50e-054106218852494
Pubmed

[Expression and significance of matrix metalloproteinase-1,9, tissue inhibitor of metalloproteinase-4 and extracellular matrix metalloproteinase inducer in the myocardium of congestive heart failure in patients with rheumatic heart diseases].

BSG MMP1

5.50e-054106219734590
Pubmed

Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization.

GRIA2 PTPN5

5.50e-054106221883219
Pubmed

Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.

KCNJ5 KCNJ11

9.15e-055106228464250
Pubmed

Expression of CD147 (EMMPRIN) on neutrophils in rheumatoid arthritis enhances chemotaxis, matrix metalloproteinase production and invasiveness of synoviocytes.

BSG MMP1

9.15e-055106220455995
Pubmed

Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury.

CCR2 SMO

9.15e-055106229632244
Pubmed

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

PIEZO1 KCNN4

9.15e-055106229576450
Pubmed

Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.

CYP2J2 CCR2 KCNJ11 MMP1 GP1BA

1.06e-04152106519578796
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE2 PLEC

1.37e-046106218827015
Pubmed

CCR2- and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion.

CCR2 FCGR1A

1.37e-046106228120849
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

FNIP2 DGKE PIGU TMEM87A ACSL4 NBAS SYNE2 ATG9A

1.60e-04504106834432599
Pubmed

Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development.

BSG MMP1

1.91e-047106217307908
Pubmed

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.

KCNJ11 KCNN4

1.91e-047106225774850
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

ZMYND15 TRPC4AP TMEM241 CYP2J2 CARMIL3 DGKE TMEM87A SLC41A2 MMP1

2.57e-04686106929987050
Pubmed

Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.

CCR2 FCGR1A

3.27e-049106224155889
Pubmed

Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.

CXCR5 CCR2

3.27e-049106212070001
Pubmed

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.

DISP2 SMO

4.08e-0410106212372301
Pubmed

Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4.

CXCR5 CCR2

4.08e-0410106210479460
Pubmed

The SIL gene is required for mouse embryonic axial development and left-right specification.

STIL SMO

4.97e-0411106210385121
Pubmed

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

GRIA2 CLRN2

4.97e-0411106231448880
Pubmed

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.

CXCR5 CCR2

5.95e-0412106228813662
Pubmed

The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity.

CCR2 FCGR1A

5.95e-0412106231801071
Pubmed

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.

CCR2 MMP1

5.95e-0412106212149192
Pubmed

p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.

SYNE2 PLEC

5.95e-0412106228595999
Pubmed

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

CDK18 PTCHD4 CSMD1

6.10e-0454106324823311
Pubmed

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.

DHX36 CYP2J2 SYNE2

6.43e-0455106318570454
Pubmed

Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.

BSG MMP1

7.02e-0413106212815621
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

CXCR5 BSG SYNE2 MACF1 SEMA4A

7.56e-04233106532290105
Pubmed

HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis.

ACSL4 USO1 MMP1 PLEC

7.94e-04135106423874603
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

KCNK12 KCNJ5 KCNJ11 KCNN4

8.85e-04139106416985003
Pubmed

Defining the membrane proteome of NK cells.

DGKE GALNT7 PIGU ACSL4 NBAS CSGALNACT2 USO1 BSG ATG9A CMTM7 STEAP1

8.86e-0411681061119946888
Pubmed

International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.

KCNJ5 KCNJ11

9.41e-0415106216382105
Pubmed

Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.

SLC38A5 SLC38A3

9.41e-0415106223506890
Pubmed

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

TRAF6 GHR CXCR5 FCGR1A MMP1 GP1BA

9.86e-04371106625241761
Pubmed

Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension.

GHR KCNJ11

1.07e-0316106217137217
Pubmed

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development.

CCR2 FCGR1A

1.21e-0317106232259484
Pubmed

Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood.

GRIA2 TMIE

1.21e-0317106232185508
Pubmed

HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism.

CXCR5 CCR2

1.21e-0317106224489825
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

CYP2J2 STIL MACF1 PLEC

1.23e-03152106434299191
Pubmed

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

POLR2A GALNT7 ACSL4 BSG TMEM192 ATG9A

1.31e-03392106633144569
Pubmed

Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.

DOCK1 KCNJ11

1.52e-0319106224564958
Pubmed

Long QT Syndrome Overview

ALG10B KCNJ5

1.52e-0319106220301308
Pubmed

Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.

TRPM8 CSMD1

1.52e-0319106224165912
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

DOCK1 PRUNE2 BNIP2 TIMM50 ATG9A

1.84e-03285106534369648
Pubmed

A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons.

CXCR5 CCR2

1.86e-0321106216129397
Pubmed

A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).

CYP2J2 CCR2 GP1BA

1.91e-0380106319420105
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

KCNJ5 KCNJ11

2.04e-0322106218391953
Pubmed

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.

ADAM20 SMO

2.23e-0323106230814516
Pubmed

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.

TM9SF1 DGKE USO1

2.34e-0386106325044020
Pubmed

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.

PIEZO1 POLR2A

2.43e-0324106232186512
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

DGKE GPR108 GALNT7 TMEM87A USO1 BSG TIMM50 SLC38A3 STEAP1

2.56e-03952106938569033
Pubmed

Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia.

GPR179 KCNJ11

2.64e-0325106235681537
Pubmed

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

TMEM241 DGKE SLC23A3

2.75e-0391106320546612
Pubmed

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

CXCR5 ORMDL3

2.85e-0326106221399635
InteractionC3orf52 interactions

PIEZO1 ADCK2 DGKE NBAS GJA8 CSGALNACT2 TMEM245 KCNJ11 NUS1 KCNN4 SMO ATG9A

4.17e-0830510112int:C3orf52
InteractionTSPAN15 interactions

TM9SF1 PIEZO1 SLC38A5 PIGU TMEM87A ZDHHC12 NUS1 TMEM192 SLC38A3 CLRN2

1.27e-0627610110int:TSPAN15
InteractionSLC41A3 interactions

CCR2 ZDHHC12 TSPO2 SMO

3.09e-05361014int:SLC41A3
InteractionZDHHC12 interactions

ADCK2 NBAS ZDHHC12 NUS1 TMEM192 ATG9A

3.61e-051231016int:ZDHHC12
InteractionAQP6 interactions

SLC52A1 SLC41A2 ORMDL3 XKR3 TMIE BSG TSPO2 TMEM97 CMTM7

4.23e-053301019int:AQP6
InteractionERGIC3 interactions

GPR182 PIGU TMEM87A CCR2 SLC41A2 ORMDL3 TSPO2 TMEM192 TMEM97

5.33e-053401019int:ERGIC3
InteractionADCK2 interactions

GPR182 ADCK2 DGKE ZDHHC12 CLRN2

6.10e-05831015int:ADCK2
InteractionSEC61A2 interactions

GPR182 ADCK2 PTPN5 TMEM192

6.31e-05431014int:SEC61A2
GeneFamilyRho GTPase activating proteins|BCH domain containing

PRUNE2 BNIP2

3.33e-0477321299
GeneFamilyEF-hand domain containing|Plakins

MACF1 PLEC

4.43e-048732939
GeneFamilyBlood group antigens|XK related family

XKR8 XKR3

8.64e-0411732955
GeneFamilyImmunoglobulin like domain containing

MXRA5 FCGR1A BSG FCRLB GPA33

1.10e-03193735594
GeneFamilyPotassium voltage-gated channel subfamily J

KCNJ5 KCNJ11

1.86e-0316732276
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MXRA5 ADAM20 SMO MMP1 SEMA4A SLC23A3

2.30e-0616110560d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCelldistal-Hematologic-Plasma-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NXPE4 SLC38A5 KCNK12 ORMDL3 QPCT SEMA4A

6.92e-0619510564280a5bc5ed9bb12e278b182e0be6cb88fa83d83
ToppCelldistal-Hematologic-Plasma|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NXPE4 SLC38A5 KCNK12 ORMDL3 QPCT SEMA4A

7.12e-0619610562a11dc1e51c64af7705e1622a9da583a6634c563
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CCL|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

THEMIS2 CEACAM4 FCGR1A QPCT KCNN4 SEMA4A

7.33e-06197105661bda9b5102fdbce902bb976d1aa62f2c799d2fb
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

TMEM241 PIEZO1 XKR8 PTPN5 SCG2 QPCT

7.99e-062001056a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCellClub_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

MXRA5 CYP2J2 CCNO BDKRB1 MMP1

3.99e-051611055342f5c61d37df61b35c18f5d258043a8f5cef629
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NXPE4 NXPE1 GALNT7 DISP2 MMP1

5.17e-0517010552c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NXPE4 NXPE1 GALNT7 DISP2 MMP1

5.17e-0517010559bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCell15-Trachea-Mesenchymal-Mesenchyme_RSPO2+|Trachea / Age, Tissue, Lineage and Cell class

LAPTM4B HTRA4 TRPM8 SMO SEMA4A

5.77e-051741055fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PRUNE2 CDK18 GHR OTOGL SEMA4A

5.77e-0517410552947e5906b172d149412fa4e77476fce4ea695d2
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 GHR PTPN5 KCNN4 SEMA4A

5.93e-0517510559a96794df049d8228fea57c1584c160191d36b56
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZMYND15 FNIP2 SLC41A2 SMO SEMA4A

6.26e-051771055e68ad19963a3d8917dfdb81127a41c4fcbe61dd5
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 SCG2 KCNJ5 QPCT DISP2

6.77e-0518010559db9899ca42455310e9b63df523fe6c4780abfb7
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 GRIA2 PTCHD4 NALCN SCG2

7.51e-0518410553e5c68a99c10eb1ddc1048bea4aa9f6b8e2746ff
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 GRIA2 PTCHD4 NALCN SCG2

7.51e-0518410551e2f0cec50475a1cf2973a5082826bbc60fc9a68
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIA2 KCNK12 NALCN SCG2 DISP2

7.71e-05185105570de48988c1f8e0809afc8092b663aa439d8e528
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 GRIA2 SCG2 QPCT TRPM8

7.91e-051861055c7983281a290201567b398e9ea6baddb96c692bb
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THEMIS2 FCGR1A NALCN BSG GPA33

7.91e-051861055cb7df8da6478b96955f3ef1394a0655ec8061bba
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 GRIA2 NALCN SCG2 QPCT

8.11e-05187105598477ba04a42a8da80a72f41a182429f46283595
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 GRIA2 NALCN SCG2 QPCT

8.74e-0519010552375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 GRIA2 NALCN SCG2 QPCT

8.74e-051901055b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

GRIA2 SCG2 KCNJ11 QPCT DISP2

8.96e-05191105576311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 DGKE GHR SCG2 DISP2

8.96e-051911055f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 SLC38A5 TSPO2 SMO TMEM97

9.18e-051921055a94f47a664a3c9d1b0250269674453309ab4bf95
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

THEMIS2 CEACAM4 FCGR1A QPCT SEMA4A

9.41e-05193105545205ad1ef12aabf33059a7ff922a3bb86994c2f
ToppCellVE-mDC1-|VE / Condition, Cell_class and T cell subcluster

ZMYND15 FNIP2 QPCT SMO SEMA4A

9.41e-0519310555df6033bc0e4f96a20d526486a8e89c990e21831
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

THEMIS2 CEACAM4 FCGR1A QPCT SEMA4A

9.41e-0519310551beca3d3b34082b7d9112fbd094bee8019921ca0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

THEMIS2 CEACAM4 FCGR1A QPCT SEMA4A

9.41e-0519310552ebb950476767f330241b0077ced22e55e124359
ToppCellVE-mDC1|VE / Condition, Cell_class and T cell subcluster

ZMYND15 FNIP2 QPCT SMO SEMA4A

9.41e-05193105512b2708db9db8b88365b8ebeb4908f28c50081bb
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Monocytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THEMIS2 CEACAM4 CCR2 FCGR1A SEMA4A

9.41e-051931055c0509798ce06da0ec725c0c7b5cc195455f2c29f
ToppCellmedial-2-Hematologic-EREG+_Dendritic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CEACAM4 CCR2 QPCT KCNN4 SEMA4A

9.64e-051941055b2b4e4c3ac0df0d9f17b930ffb60c0fd85b3dd78
ToppCellmedial-Hematologic-EREG+_Dendritic-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CEACAM4 CCR2 QPCT KCNN4 SEMA4A

9.64e-05194105515f3b6b6579e388d0820f05e93a77ee1634bd6c3
ToppCellRA|World / Chamber and Cluster_Paper

PRUNE2 C5AR2 ACSL4 OTOGL SEMA4A

9.64e-05194105508f0afbb68a63150fbe107a5337299081c3f69e4
ToppCellmedial-Hematologic-EREG+_Dendritic|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CEACAM4 CCR2 QPCT KCNN4 SEMA4A

9.64e-0519410551f3d22292d2691f93aa7b6770f5c250a33db3cc0
ToppCell11.5-Airway-Epithelial-Secretory_progenitor|Airway / Age, Tissue, Lineage and Cell class

CYP2J2 CCNO AP1M2 SLC41A2 ZDHHC12

9.87e-0519510558cbc78a6cb812f907c69b00f85263976216840ac
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NXPE4 AP1M2 NXPE1 QPCT GPA33

9.87e-0519510559c24ebce2e3e00b8b692c62a22a53b7d59f0eabb
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GRIA2 NALCN SCG2 KCNJ11 QPCT

9.87e-0519510555f33ece997f074598b4201ff74f592ee07c86a06
ToppCelldistal-1-Hematologic-Plasma|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NXPE4 SLC38A5 KCNK12 QPCT SEMA4A

1.04e-041971055f5499bfa9dbc111f12563b7006bc45c2423ad0cd
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRUNE2 CDK18 NXPE1 BSG GPA33

1.06e-041981055efdbac7a3a02bff4ca48841772e0c136556c2b9b
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC38A5 GPR146 BSG QPCT SLC38A3

1.06e-0419810550a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

THEMIS2 CEACAM4 CCR2 KCNN4 SEMA4A

1.06e-041981055f44eb16695ea52e3f99073f5976590069b1d9c5a
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ZMYND15 THEMIS2 FCGR1A KCNJ5 GP1BA

1.09e-041991055514dbf128b6832b1cbd65be023d4fe02400e8dec
ToppCellmoderate-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FNIP2 CSGALNACT2 KCNN4 MACF1 PLEC

1.09e-0419910553895e367a33ac0316f96a64c07574de99684f4b7
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

THEMIS2 C5AR2 CCR2 SLC41A2 FCGR1A

1.09e-0419910554e0b73d88b1345ec63a9e5629762341e75beb47f
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THEMIS2 CEACAM4 C5AR2 HTRA4 KCNJ5

1.09e-04199105598c0d57c247d39bc771d81f4387f8dd01222628e
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRUNE2 CDK18 BSG PLEC GPA33

1.09e-04199105501d101b0fd5326947a9e5dddae6c2f93ab6e0a4d
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PIEZO1 SLC38A5 BDKRB1 BSG PLEC

1.09e-04199105585bb28369e0568b7b3bda095722102fc793f60ef
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THEMIS2 CEACAM4 C5AR2 HTRA4 KCNJ5

1.09e-041991055b818d46a39c8782188d82dc8931b8eec9d549dd1
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FNIP2 HTRA4 FCGR1A KCNJ5 QPCT

1.09e-041991055f987f48970aec46156b80656e49b9f3604f3758c
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRUNE2 CDK18 BSG PLEC GPA33

1.09e-0419910556d439c0c5e6b72fcb8d4dc72e7445eb6a01fe095
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK1 SLC38A5 BSG SYNE2 SLC38A3

1.11e-042001055032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-4|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MXRA5 SLC38A5 BDKRB1 SCG2 STEAP1

1.11e-0420010557642a14855589b0b3f68dbdc9e4d3fc7291854f7
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK1 SLC38A5 BSG SYNE2 SLC38A3

1.11e-04200105568fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK1 SLC38A5 BSG SYNE2 SLC38A3

1.11e-042001055376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-4-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MXRA5 SLC38A5 BDKRB1 SCG2 STEAP1

1.11e-042001055444c72334df421375ae6fc69b0adfd4950d49a43
ToppCellSepsis-ICU-NoSEP-Myeloid-cDC2|ICU-NoSEP / Disease, condition lineage and cell class

CDK18 TMEM182 SLC41A2 TMEM97 SEMA4A

1.11e-04200105559cb0b0dee2599b3d3014b66d71d84c22b5de4b2
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-4|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MXRA5 SLC38A5 BDKRB1 SCG2 STEAP1

1.11e-0420010555826c17da67bdaba3a828792279004218d8260c8
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK1 SLC38A5 BSG SYNE2 SLC38A3

1.11e-0420010557fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC38A5 GPR146 BSG QPCT SLC38A3

1.11e-042001055c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK1 SLC38A5 BSG SYNE2 SLC38A3

1.11e-042001055878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK1 SLC38A5 BSG SYNE2 SLC38A3

1.11e-0420010557136936d05ab344a560cf159684c881063b5430d
ToppCell(50)_cDC2|World / shred on Cell_type and subtype

ZMYND15 FNIP2 CEACAM4 TMEM97 MMP1

1.28e-042061055d519adeb8290fcce107e81a439ba3bf1e231b55b
DrugEserine sulfate, physostigmine sulfate [64-47-1]; Down 200; 6.2uM; MCF7; HT_HG-U133A

DOCK1 TRAF6 CYP2J2 CCNO DGKE USO1 MACF1 PLEC

3.71e-0619710582768_DN
DiseaseXerocytosis

PIEZO1 KCNN4

1.07e-052972cv:C0272051
Diseasemyocardial infarction (is_implicated_in)

CYP2J2 CCR2 KCNN4 MMP1 GP1BA

1.94e-0599975DOID:5844 (is_implicated_in)
DiseaseXerocytosis

PIEZO1 KCNN4

3.20e-053972C0272051
Diseaserenal fibrosis (is_implicated_in)

CYP2J2 MMP1

1.06e-045972DOID:0050855 (is_implicated_in)
Diseaseficolin-2 measurement

NXPE4 NXPE1

1.06e-045972EFO_0008135
DiseaseSUN domain-containing protein 3 measurement

NXPE4 NXPE1

1.06e-045972EFO_0802102
Diseasefeeling nervous measurement

TMEM182 TRPC4AP PIGU CSMD1

1.98e-0487974EFO_0009597
Diseaseglycolipid transfer protein domain-containing protein 2 measurement

ZMYND15 SLC52A1

3.79e-049972EFO_0801643
DiseaseCongenital long QT syndrome

ALG10B KCNJ5

5.77e-0411972cv:C1141890
DiseaseLong QT syndrome

ALG10B KCNJ5

6.91e-0412972cv:C0023976
Diseaseliver cirrhosis (implicated_via_orthology)

SMO MMP1

8.15e-0413972DOID:5082 (implicated_via_orthology)
Diseaseatrial fibrillation (is_implicated_in)

KCNJ5 MMP1

9.49e-0414972DOID:0060224 (is_implicated_in)
Diseasepsychosis

TMEM182 NALCN

9.49e-0414972EFO_0005407
Diseasemannan-binding lectin serine protease 1 measurement

NXPE4 NXPE1

1.09e-0315972EFO_0008223
Diseasesystemising measurement

NBAS ORMDL3

2.16e-0321972EFO_0010221
Diseasecardioembolic stroke

POLR2A GJA8 KCNJ5 SYNE2

2.43e-03170974EFO_1001976
Diseasesnoring measurement

TMEM182 POLR2A MACF1

2.71e-0384973EFO_0008341
Diseasesquamous cell lung carcinoma, family history of lung cancer

ESM1 GHR NBAS

2.80e-0385973EFO_0000708, EFO_0006953

Protein segments in the cluster

PeptideGeneStartEntry
HLLITIYSALIFIPW

ACSL4

16

O60488
VLIPVHLITSGVWFG

FAM210A

136

Q96ND0
IWVVGGLLSIPTFLL

BDKRB1

161

P46663
YLAPSVSTLWLHLLL

ADCK2

121

Q7Z695
QGLLITASLLTFWHP

CEACAM4

16

O75871
LAPLLSHGQVHFLWI

AP1M2

46

Q9Y6Q5
IHITCGTIWLVGFLL

CXCR5

166

P32302
GTIWLVGFLLALPEI

CXCR5

171

P32302
VWLIISEPGSRIHLI

CSMD1

611

Q96PZ7
LLSWLIPVHRQFGLS

CCNO

136

P22674
ALWAVVHPRTLLLGT

CYP2J2

11

P51589
PLVHIRVTLLLLWFG

ADAM20

6

O43506
HLIFRLLGTPTEETW

CDK18

351

Q07002
LSLVWKHGILFLVVT

ALG10B

316

Q5I7T1
PLPRHFILFISLIGW

ADGRG7

561

Q96K78
VLVHLALTLVWLPAS

DISP2

626

A7MBM2
GTLHLLLLVAALPWA

QPCT

11

Q16769
WGVPSLLLVFLSVGL

PTPN5

141

P54829
EVLWGHRFTPVLTLE

KCNJ5

326

P48544
HLIWKILPYIGTTVG

OR2T1

36

O43869
HLSDTLWLIPITFLT

KCNN4

236

O15554
LLLTHTERVVIWPFS

GPA33

61

Q99795
FVLVPSLHPDWTLLL

GPR179

596

Q6PRD1
ALTSWRLHLFLLKVP

CARMIL3

46

Q8ND23
TTLVDLKWPHTLLIF

KCNJ11

61

Q14654
HISVLLSPVLWGLIF

GRIA2

6

P42262
LAGWKPSVYHVLLIL

KCNK12

206

Q9HB15
TITTLPTVLGVLWFH

OR51T1

76

Q8NGJ9
LGFLPWHIRLTEIVS

NUS1

251

Q96E22
HVRTGTILLGVWYLI

LAPTM4B

111

Q86VI4
IHFSGKLSIWAIPSL

NBAS

336

A2RRP1
IIIVCSLLFPVLWHL

PIGU

361

Q9H490
PKLTLGLIWTIILHF

MACF1

166

Q9UPN3
WGLLTAPTLVVLHET

MFSD14A

51

Q96MC6
LSILGHFPRALVWVS

POP1

846

Q99575
HFPRALVWVSLSLLS

POP1

851

Q99575
LIVIRTPVPGLFHLW

CSGALNACT2

471

Q8N6G5
LLLVPVLWAGAEKLH

HTRA4

21

P83105
LWVTLKLLPGDIHQI

DOCK1

381

Q14185
WAPYHLLGLVLTVAA

C5AR2

246

Q9P296
PWLLIIIFGIFGLTV

GHR

266

P10912
SLLVVGSFLGLVVLW

GALNT7

11

Q86SF2
RLVLTSEHWLVLVPF

GALT

231

P07902
ALLTAVLTYHLAWVP

FNIP2

436

Q9P278
ILVFLPGWDNISTLH

DHX36

491

Q9H2U1
SLITILVIAGVFWIH

ATG9A

131

Q7Z3C6
PISHIRLWVLQIIFV

GJA8

71

P48165
PVHLTSWLLIFFILK

HYAL4

16

Q2M3T9
HLAALWPFLGIVAEV

BSG

321

P35613
ISDLLFLITLPLWAH

CCR2

86

P41597
IVHPSWFIRTLLAVT

BNIP2

246

Q12982
VVLILLLSWVGHVKP

GP1BA

546

P07359
LGLQLPTPVWFHVLF

FCGR1A

281

P12314
LLTTLLVPAHLVAAW

ESM1

6

Q9NQ30
HLILWTLCSVLLPVF

DGKE

21

P52429
LLELQPISTLWYLGH

FCRLB

51

Q6BAA4
WTPHYLILLGHTVII

GPR146

246

Q96CH1
HEILAGFLSLIPAWA

HSD17B3

271

P37058
WLTGAIAVLEHPLAL

NHLRC1

271

Q6VVB1
IPWSIFLLHVLLFSL

OTOGL

11

Q3ZCN5
PAGLIIKWSHLTGII

OTOGL

1651

Q3ZCN5
GIWLSYVLAIGLLHI

ORMDL3

21

Q8N138
FWEGQVSLSLLLIHP

NXPE1

171

Q8N323
SQHWIALPLGILYLL

OR52L1

41

Q8NGH7
FLHSLVQLLLVLWLP

OR4C3

151

Q8NH37
SQHWIALPLGILYLL

OR52L2P

41

Q8NGH6
FHVRWPGVKLLTSLL

USO1

136

O60763
EFSWLRHVLIAVGLL

SLC38A3

401

Q99624
FIIVHPSWFIRTILA

PRUNE2

2996

Q8WUY3
WSGIPQLLLKLHTTS

TRPC4AP

71

Q8TEL6
PSIILGLIWTIILHF

SYNE2

121

Q8WXH0
WEGQVSLSLLLIHPS

NXPE4

171

Q6UWF7
PLLLLLFWGVVSHSF

MMP1

6

P03956
FSWPRHVAIALILLV

SLC38A5

371

Q8WUX1
GAILFPVVWSIRHLQ

GPR108

411

Q9NPR9
WLPYHVTLLLLTLHG

GPR182

271

O15218
HPLGNFWLILSVTSI

PTCHD4

681

Q6ZW05
WPHFVTVTVLFALVL

SEMA4A

681

Q9H3S1
THWLGAALSLIPLIF

SCG2

6

P13521
FLALTPIWIIIAAKH

SLC41A2

356

Q96JW4
VLFSTGWSPLDVLLH

SLC23A3

476

Q6PIS1
WHLPIKIAAIIASLT

STEAP1

71

Q9UHE8
ISWPLSELLHYLIGT

CMTM7

106

Q96FZ5
FILIIVALVVPHWLS

CLRN2

21

A0PK11
SLPLVGIWLSGITHI

STIL

256

Q15468
PTVIIVNLLWFIHLV

TMEM192

46

Q8IY95
VLELTGVLLHPEWSL

TIMM50

151

Q3ZCQ8
VLSVVGTALLAPLWH

SLC52A1

86

Q9NWF4
LWHVVGIFSLFVLSI

TMIE

56

Q8NEW7
WTGKQIFSLIIPGHI

POLR2A

586

P24928
HLPWPFQGTIRLTIL

TRAF6

421

Q9Y4K3
VHFIKPLLLSEVLAW

THEMIS2

241

Q5TEJ8
EWLLGLYFLSHIPIT

TMEM97

11

Q5BJF2
NPKLTLGLIWTIILH

PLEC

266

Q15149
HLLTWSLPFVLTVAI

SMO

361

Q99835
RSHVLVWLPASVLFV

TMEM241

66

Q24JQ0
SIPVWIILLFHLASL

TMEM245

221

Q9H330
AIFVLLPHLGPILVW

TSPO2

6

Q5TGU0
KAALLFWHILLLGPI

XKR3

96

Q5GH77
GGLIILFLIAIIWFP

PIEZO1

2176

Q92508
ITRHPLQALFIWAIL

TRPM8

556

Q7Z2W7
GHTVLTWGITLVLFL

ZDHHC12

16

Q96GR4
SLLAGLLFLVVGWHI

TMEM182

211

Q6ZP80
VFWELLVLLPHVALE

ZMYND15

526

Q9H091
WLQVLPVILLLLGAH

TMEM87A

6

Q8NBN3
GFFPRTLEIHWLSII

TM9SF1

226

O15321
PSYVALHFLGLWLVL

XKR8

226

Q9H6D3
TSLGVVWVVLHFALL

NALCN

1281

Q8IZF0
SVVLILLWGHPRVAL

MXRA5

11

Q9NR99