Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	unmethylated CpG binding	KDM2B KDM2A TLR9	4.45e-07	10	32	3	GO:0045322
GeneOntologyMolecularFunction	histone H3K36me/H3K36me2 demethylase activity	KDM2B KDM2A	1.49e-05	4	32	2	GO:0140680
GeneOntologyMolecularFunction	adrenergic receptor activity	ADRA1D ADRB1	1.11e-04	10	32	2	GO:0004935
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM2B KDM2A	1.36e-04	11	32	2	GO:0051864
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM2B KDM2A	9.16e-04	28	32	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM2B KDM2A	1.12e-03	31	32	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM2B KDM2A	1.20e-03	32	32	2	GO:0140457
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	ADRA1D ADRB1	1.96e-03	41	32	2	GO:0008227
GeneOntologyMolecularFunction	demethylase activity	KDM2B KDM2A	2.26e-03	44	32	2	GO:0032451
GeneOntologyBiologicalProcess	positive regulation of the force of heart contraction by chemical signal	ADRB1 EDN2	2.04e-05	5	30	2	GO:0003099
GeneOntologyBiologicalProcess	positive regulation of blood pressure by epinephrine-norepinephrine	ADRA1D ADRB1	4.28e-05	7	30	2	GO:0003321
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	ADRA1D ADRB1	5.70e-05	8	30	2	GO:0001993
GeneOntologyBiologicalProcess	regulation of the force of heart contraction by chemical signal	ADRB1 EDN2	5.70e-05	8	30	2	GO:0003057
GeneOntologyBiologicalProcess	protein demethylation	KDM2B KDM2A	9.14e-05	10	30	2	GO:0006482
GeneOntologyBiologicalProcess	protein dealkylation	KDM2B KDM2A	9.14e-05	10	30	2	GO:0008214
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure mediated by a chemical signal	ADRA1D ADRB1 EDN2	9.44e-05	61	30	3	GO:0003044
GeneOntologyBiologicalProcess	positive regulation of B cell activation	ATP11C TLR9 CHRNB2	4.08e-04	100	30	3	GO:0050871
GeneOntologyBiologicalProcess	regulation of heart contraction	KCNG2 ADRA1D ADRB1 EDN2	4.44e-04	249	30	4	GO:0008016
GeneOntologyBiologicalProcess	demethylation	KDM2B KDM2A	5.53e-04	24	30	2	GO:0070988
GeneOntologyBiologicalProcess	eye development	KDM2B CACNA1F SLC39A5 PRSS56 GAS1	5.89e-04	480	30	5	GO:0001654
GeneOntologyBiologicalProcess	adenylate cyclase-activating adrenergic receptor signaling pathway	ADRA1D ADRB1	6.01e-04	25	30	2	GO:0071880
GeneOntologyBiologicalProcess	visual system development	KDM2B CACNA1F SLC39A5 PRSS56 GAS1	6.06e-04	483	30	5	GO:0150063
GeneOntologyBiologicalProcess	sensory system development	KDM2B CACNA1F SLC39A5 PRSS56 GAS1	6.52e-04	491	30	5	GO:0048880
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure	ADRA1D ADRB1 EDN2	7.65e-04	124	30	3	GO:0003073
GeneOntologyBiologicalProcess	heart contraction	KCNG2 ADRA1D ADRB1 EDN2	8.70e-04	298	30	4	GO:0060047
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1F KCNG2 ATP11C ADRB1 TLR9 SLC39A5 CHRNB2	9.00e-04	1115	30	7	GO:0034220
GeneOntologyBiologicalProcess	regulation of circadian sleep/wake cycle, sleep	ADRB1 CHRNB2	9.26e-04	31	30	2	GO:0045187
GeneOntologyBiologicalProcess	smooth muscle contraction	ADRB1 EDN2 CHRNB2	9.37e-04	133	30	3	GO:0006939
GeneOntologyBiologicalProcess	regulation of circadian rhythm	KDM2A ADRB1 CHRNB2	9.78e-04	135	30	3	GO:0042752
GeneOntologyBiologicalProcess	negative regulation of systemic arterial blood pressure	ADRA1D ADRB1	9.87e-04	32	30	2	GO:0003085
GeneOntologyBiologicalProcess	heart process	KCNG2 ADRA1D ADRB1 EDN2	9.96e-04	309	30	4	GO:0003015
GeneOntologyBiologicalProcess	regulation of the force of heart contraction	ADRB1 EDN2	1.05e-03	33	30	2	GO:0002026
GeneOntologyBiologicalProcess	circadian sleep/wake cycle, sleep	ADRB1 CHRNB2	1.05e-03	33	30	2	GO:0050802
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1F ADRB1 SLC39A5	1.13e-03	142	30	3	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1F ADRB1 SLC39A5	1.13e-03	142	30	3	GO:0098659
GeneOntologyBiologicalProcess	regulation of circadian sleep/wake cycle	ADRB1 CHRNB2	1.18e-03	35	30	2	GO:0042749
GeneOntologyBiologicalProcess	positive regulation of heart rate	ADRB1 EDN2	1.18e-03	35	30	2	GO:0010460
GeneOntologyBiologicalProcess	adrenergic receptor signaling pathway	ADRA1D ADRB1	1.18e-03	35	30	2	GO:0071875
GeneOntologyBiologicalProcess	regulation of blood circulation	KCNG2 ADRA1D ADRB1 EDN2	1.21e-03	326	30	4	GO:1903522
GeneOntologyBiologicalProcess	circadian sleep/wake cycle process	ADRB1 CHRNB2	1.25e-03	36	30	2	GO:0022410
GeneOntologyBiologicalProcess	sleep	ADRB1 CHRNB2	1.54e-03	40	30	2	GO:0030431
GeneOntologyBiologicalProcess	negative regulation of calcium ion transmembrane transporter activity	CACNA1F TLR9	1.62e-03	41	30	2	GO:1901020
GeneOntologyBiologicalProcess	growth	KDM2B CCN5 KDM2A ADRB1 EDN2 SPTBN2 GAS1	1.63e-03	1235	30	7	GO:0040007
GeneOntologyBiologicalProcess	regulation of B cell activation	ATP11C TLR9 CHRNB2	1.68e-03	163	30	3	GO:0050864
GeneOntologyBiologicalProcess	rhythmic process	KDM2A ADRB1 EDN2 CHRNB2	1.75e-03	360	30	4	GO:0048511
GeneOntologyBiologicalProcess	circadian sleep/wake cycle	ADRB1 CHRNB2	1.78e-03	43	30	2	GO:0042745
GeneOntologyBiologicalProcess	cell growth	KDM2B CCN5 ADRB1 EDN2 GAS1	1.91e-03	625	30	5	GO:0016049
GeneOntologyBiologicalProcess	neural tube patterning	KDM2B GAS1	1.95e-03	45	30	2	GO:0021532
GeneOntologyBiologicalProcess	regulation of B cell differentiation	ATP11C TLR9	2.03e-03	46	30	2	GO:0045577
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1F ADRB1	2.21e-03	48	30	2	GO:0098703
GeneOntologyBiologicalProcess	chromosome condensation	PRM1 PRM2	2.21e-03	48	30	2	GO:0030261
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1F ADRB1	2.21e-03	48	30	2	GO:1902656
GeneOntologyCellularComponent	male germ cell nucleus	TCFL5 PRM1 PRM2	2.78e-04	86	31	3	GO:0001673
GeneOntologyCellularComponent	germ cell nucleus	TCFL5 PRM1 PRM2	6.19e-04	113	31	3	GO:0043073
Domain	PHD_4	KDM2B KDM2A	7.99e-06	3	31	2	PF16866
Domain	ADR_fam	ADRA1D ADRB1	1.19e-04	10	31	2	IPR002233
Domain	zf-CXXC	KDM2B KDM2A	1.45e-04	11	31	2	PF02008
Domain	Znf_CXXC	KDM2B KDM2A	1.45e-04	11	31	2	IPR002857
Domain	ZF_CXXC	KDM2B KDM2A	1.45e-04	11	31	2	PS51058
Domain	Leu-rich_rpt_Cys-con_subtyp	KDM2B KDM2A	4.48e-04	19	31	2	IPR006553
Domain	LRR_CC	KDM2B KDM2A	4.48e-04	19	31	2	SM00367
Domain	JmjC	KDM2B KDM2A	7.19e-04	24	31	2	PF02373
Domain	JMJC	KDM2B KDM2A	1.28e-03	32	31	2	PS51184
Domain	JmjC_dom	KDM2B KDM2A	1.28e-03	32	31	2	IPR003347
Domain	JmjC	KDM2B KDM2A	1.36e-03	33	31	2	SM00558
Domain	FBOX	KDM2B KDM2A	3.36e-03	52	31	2	SM00256
Domain	Channel_four-helix_dom	CACNA1F KCNG2	4.02e-03	57	31	2	IPR027359
Domain	-	CACNA1F KCNG2	4.02e-03	57	31	2	1.20.120.350
Domain	CH	EHBP1L1 SPTBN2	5.20e-03	65	31	2	SM00033
Domain	F-box	KDM2B KDM2A	5.51e-03	67	31	2	PF00646
Domain	CH	EHBP1L1 SPTBN2	6.00e-03	70	31	2	PF00307
Domain	-	EHBP1L1 SPTBN2	6.17e-03	71	31	2	1.10.418.10
Domain	FBOX	KDM2B KDM2A	6.34e-03	72	31	2	PS50181
Domain	CH	EHBP1L1 SPTBN2	6.51e-03	73	31	2	PS50021
Domain	CH-domain	EHBP1L1 SPTBN2	6.86e-03	75	31	2	IPR001715
Domain	F-box_dom	KDM2B KDM2A	6.86e-03	75	31	2	IPR001810
Domain	Znf_PHD-finger	KDM2B KDM2A	7.59e-03	79	31	2	IPR019787
Domain	PHD	KDM2B KDM2A	9.54e-03	89	31	2	SM00249
Domain	Znf_PHD	KDM2B KDM2A	9.96e-03	91	31	2	IPR001965
Domain	ZF_PHD_2	KDM2B KDM2A	1.08e-02	95	31	2	PS50016
Domain	ZF_PHD_1	KDM2B KDM2A	1.10e-02	96	31	2	PS01359
Domain	7TM_GPCR_Srsx	ADRA1D ADRB1	1.48e-02	112	31	2	SM01381
Domain	Ion_trans_dom	CACNA1F KCNG2	1.53e-02	114	31	2	IPR005821
Domain	Ion_trans	CACNA1F KCNG2	1.53e-02	114	31	2	PF00520
Domain	-	KDM2B KDM2A TLR9	1.58e-02	321	31	3	3.80.10.10
Domain	L_dom-like	KDM2B KDM2A TLR9	1.68e-02	328	31	3	IPR032675
Pathway	REACTOME_ADRENOCEPTORS	ADRA1D ADRB1	1.08e-04	9	25	2	M27302
Pathway	REACTOME_ADRENOCEPTORS	ADRA1D ADRB1	1.08e-04	9	25	2	MM15009
Pubmed	Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice.	ADRA1D ADRB1	8.20e-07	2	32	2	26203906
Pubmed	Synthesis and processing of mammalian protamines and transition proteins.	PRM1 PRM2	8.20e-07	2	32	2	8185929
Pubmed	Gene expression during spermatogenesis.	PRM1 PRM2	8.20e-07	2	32	2	3445973
Pubmed	Polymorphisms of sperm protamine genes and CMA3 staining in infertile men with varicocele.	PRM1 PRM2	8.20e-07	2	32	2	30482464
Pubmed	Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes.	PRM1 PRM2	8.20e-07	2	32	2	18343090
Pubmed	The effects of bacterial infection on human sperm nuclear protamine P1/P2 ratio and DNA integrity.	PRM1 PRM2	8.20e-07	2	32	2	28736810
Pubmed	Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.	PRM1 PRM2	8.20e-07	2	32	2	12569175
Pubmed	cDNA clones encoding cytoplasmic poly(A)+ RNAs which first appear at detectable levels in haploid phases of spermatogenesis in the mouse.	PRM1 PRM2	8.20e-07	2	32	2	6688229
Pubmed	Protamine 1/Protamine 2 mRNA ratio in nonobstructive azoospermic patients.	PRM1 PRM2	8.20e-07	2	32	2	33427330
Pubmed	A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts.	PRM1 PRM2	8.20e-07	2	32	2	19863670
Pubmed	Both P1 and P2 protamine genes are expressed in mouse, hamster, and rat.	PRM1 PRM2	8.20e-07	2	32	2	3676400
Pubmed	Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genes.	PRM1 PRM2	8.20e-07	2	32	2	21029114
Pubmed	Biological Functions of the KDM2 Family of Histone Demethylases.	KDM2B KDM2A	8.20e-07	2	32	2	37751135
Pubmed	Evaluation of protamines 1 and 2 transcript contents in spermatozoa from asthenozoospermic men.	PRM1 PRM2	8.20e-07	2	32	2	18292846
Pubmed	Haploinsufficiency of protamine-1 or -2 causes infertility in mice.	PRM1 PRM2	8.20e-07	2	32	2	11326282
Pubmed	Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2.	PRM1 PRM2	8.20e-07	2	32	2	3527226
Pubmed	KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.	KDM2B KDM2A	8.20e-07	2	32	2	31363749
Pubmed	Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression.	PRM1 PRM2	8.20e-07	2	32	2	33057064
Pubmed	Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered.	PRM1 PRM2	8.20e-07	2	32	2	2081589
Pubmed	Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas.	KDM2B KDM2A	8.20e-07	2	32	2	32901907
Pubmed	Impact of protamine transcripts and their proteins on the quality and fertilization ability of sperm and the development of preimplantation embryos.	PRM1 PRM2	8.20e-07	2	32	2	22472940
Pubmed	Sexual selection drives weak positive selection in protamine genes and high promoter divergence, enhancing sperm competitiveness.	PRM1 PRM2	8.20e-07	2	32	2	19364735
Pubmed	Germ cell-specific proteins interact with the 3' untranslated regions of Prm-1 and Prm-2 mRNA.	PRM1 PRM2	8.20e-07	2	32	2	7813783
Pubmed	Chromosomal localization of the human protamine genes, PRM1 and PRM2, to 16p13.3 by in situ hybridization.	PRM1 PRM2	8.20e-07	2	32	2	2370044
Pubmed	Characterization of nucleohistone and nucleoprotamine components in the mature human sperm nucleus.	PRM1 PRM2	8.20e-07	2	32	2	18478156
Pubmed	Protamine 2 precursors (Pre-P2), protamine 1 to protamine 2 ratio (P1/P2), and assisted reproduction outcome.	PRM1 PRM2	8.20e-07	2	32	2	18314125
Pubmed	Protamine-1 and -2 polymorphisms and gene expression in male infertility: an Italian study.	PRM1 PRM2	8.20e-07	2	32	2	22104739
Pubmed	Expression of sperm-specific protamines impairs bacterial and eukaryotic cell proliferation.	PRM1 PRM2	8.20e-07	2	32	2	25649960
Pubmed	Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability.	PRM1 PRM2	8.20e-07	2	32	2	17011555
Pubmed	Unexplained recurrent miscarriages are associated with an aberrant sperm protamine mRNA content.	PRM1 PRM2	8.20e-07	2	32	2	28854581
Pubmed	Mapping of haploid expressed genes: genes for both mouse protamines are located on chromosome 16.	PRM1 PRM2	8.20e-07	2	32	2	3008352
Pubmed	Mapping of PRM1 to human chromosome 16 and tight linkage of Prm-1 and Prm-2 on mouse chromosome 16.	PRM1 PRM2	8.20e-07	2	32	2	2614060
Pubmed	Identification of genetic variation in the 5' and 3' non-coding regions of the protamine genes in patients with protamine deregulation.	PRM1 PRM2	8.20e-07	2	32	2	18309899
Pubmed	Quantification of sperm specific mRNA transcripts (PRM1, PRM2, and TNP2) in teratozoospermia and normozoospermia: New correlations between mRNA content and morphology of sperm.	PRM1 PRM2	2.46e-06	3	32	2	25536093
Pubmed	Rapid evolution of male reproductive genes in the descent of man.	PRM1 PRM2	2.46e-06	3	32	2	10659848
Pubmed	Sequence homologies in the mouse protamine 1 and 2 genes.	PRM1 PRM2	2.46e-06	3	32	2	3358932
Pubmed	Reciprocal regulation of the mouse protamine genes by the orphan nuclear receptor germ cell nuclear factor and CREMtau.	PRM1 PRM2	2.46e-06	3	32	2	15236322
Pubmed	Characterization of a human locus in transition.	PRM1 PRM2	2.46e-06	3	32	2	7983046
Pubmed	Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2 genes variants on male infertility.	PRM1 PRM2	2.46e-06	3	32	2	36217675
Pubmed	Mutations in the protamine locus: association with spermatogenic failure?	PRM1 PRM2	2.46e-06	3	32	2	19602509
Pubmed	Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin.	KDM2B KDM2A	2.46e-06	3	32	2	26004508
Pubmed	Genomic analysis of the mouse protamine 1, protamine 2, and transition protein 2 gene cluster reveals hypermethylation in expressing cells.	PRM1 PRM2	2.46e-06	3	32	2	9107674
Pubmed	A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.	KDM2B KDM2A	2.46e-06	3	32	2	30033217
Pubmed	Genetic Polymorphisms in PRM1, PRM2, and YBX2 Genes are Associated with Male Factor Infertility.	PRM1 PRM2	2.46e-06	3	32	2	29227750
Pubmed	Norepinephrine suppresses gonadotropin-releasing hormone neuron excitability in the adult mouse.	ADRA1D ADRB1	2.46e-06	3	32	2	18079196
Pubmed	Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.	ADRA1D ADRB1	2.46e-06	3	32	2	15598970
Pubmed	Histone demethylation by a family of JmjC domain-containing proteins.	KDM2B KDM2A	4.92e-06	4	32	2	16362057
Pubmed	Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.	ADRA1D ADRB1	4.92e-06	4	32	2	31230416
Pubmed	Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos.	PRM1 PRM2	4.92e-06	4	32	2	18292840
Pubmed	Nuclear matrix interactions at the human protamine domain: a working model of potentiation.	PRM1 PRM2	4.92e-06	4	32	2	15452126
Pubmed	A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells.	PRM1 PRM2	4.92e-06	4	32	2	10369260
Pubmed	Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter.	PRM1 PRM2	4.92e-06	4	32	2	10369265
Pubmed	Characterization of four genes encoding basic proteins of the porcine spermatid nucleus and close linkage of three of them.	PRM1 PRM2	4.92e-06	4	32	2	1627265
Pubmed	The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome.	PRM1 PRM2	4.92e-06	4	32	2	1395729
Pubmed	Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility.	PRM1 PRM2	4.92e-06	4	32	2	16989827
Pubmed	Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.	PRM1 PRM2	8.19e-06	5	32	2	33440036
Pubmed	Apoptotic gene expression in potentially fertile and subfertile men.	PRM1 PRM2	8.19e-06	5	32	2	21317160
Pubmed	The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells.	PRM1 PRM2	8.19e-06	5	32	2	15665108
Pubmed	Role of follitropin receptor signaling in nuclear protein transitions and chromatin condensation during spermatogenesis.	PRM1 PRM2	8.19e-06	5	32	2	14680821
Pubmed	Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia.	PRM1 PRM2	8.19e-06	5	32	2	18692784
Pubmed	Chromosomal organization of adrenergic receptor genes.	ADRA1D ADRB1	8.19e-06	5	32	2	2154750
Pubmed	Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene.	PRM1 PRM2	8.19e-06	5	32	2	8720108
Pubmed	Comparison of interspecific to intersubspecific backcrosses demonstrates species and sex differences in recombination frequency on mouse chromosome 16.	PRM1 PRM2	1.23e-05	6	32	2	1797230
Pubmed	Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells.	ADRA1D ADRB1	1.23e-05	6	32	2	12184796
Pubmed	Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.	ADRA1D ADRB1	2.29e-05	8	32	2	16533813
Pubmed	Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.	ADRA1D ADRB1	2.29e-05	8	32	2	9139936
Pubmed	Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994.	PRM1 PRM2	2.94e-05	9	32	2	7842732
Pubmed	Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.	ADRA1D ADRB1	2.94e-05	9	32	2	21209093
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KDM2B KDM2A	3.67e-05	10	32	2	29276034
Pubmed	Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice.	PRM1 PRM2	3.67e-05	10	32	2	17130239
Pubmed	Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.	KDM2B KDM2A	7.41e-05	14	32	2	21220025
Pubmed	SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.	KDM2B KDM2A	7.41e-05	14	32	2	17463251
Pubmed	Mapping of six germ-cell-specific genes to mouse chromosomes.	PRM1 PRM2	7.41e-05	14	32	2	9337410
Pubmed	The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators.	KDM2B KDM2A	8.55e-05	15	32	2	25463925
Pubmed	The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.	PRM1 PRM2	1.24e-04	18	32	2	23637336
Pubmed	The complexity of antisense transcription revealed by the study of developing male germ cells.	PRM1 PRM2	1.24e-04	18	32	2	16458478
Pubmed	The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.	PRM1 PRM2	1.39e-04	19	32	2	27040500
Pubmed	The histone H3K36 demethylase Fbxl11 plays pivotal roles in the development of retinal late-born cell types.	KDM2B KDM2A	1.54e-04	20	32	2	37073980
Pubmed	ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.	PRM1 PRM2	1.70e-04	21	32	2	31932482
Pubmed	Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.	ADRA1D ADRB1	1.70e-04	21	32	2	1676978
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM2B KDM2A	1.70e-04	21	32	2	27626377
Pubmed	Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.	PRM1 PRM2	1.87e-04	22	32	2	16024815
Pubmed	Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.	ADRA1D ADRB1	2.43e-04	25	32	2	19855129
Pubmed	TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.	PRM1 PRM2	3.28e-04	29	32	2	21383078
Pubmed	Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.	PRM1 PRM2	3.28e-04	29	32	2	22190364
Pubmed	High-resolution recombinational map of mouse chromosome 16.	PRM1 PRM2	4.25e-04	33	32	2	9244437
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	KDM2B KDM2A	4.52e-04	34	32	2	30894540
Pubmed	Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.	PRM1 PRM2	6.26e-04	40	32	2	20378615
Pubmed	A family of mammalian F-box proteins.	KDM2B KDM2A	6.90e-04	42	32	2	10531037
Pubmed	Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.	CCN5 PSMD8 BACH2	7.98e-04	198	32	3	27480124
Cytoband	16p13.2	PRM1 PRM2	4.91e-05	15	32	2	16p13.2
GeneFamily	Adrenoceptors	ADRA1D ADRB1	5.54e-05	9	23	2	169
GeneFamily	Zinc fingers CXXC-type	KDM2B KDM2A	1.01e-04	12	23	2	136
GeneFamily	F-box and leucine rich repeat proteins	KDM2B KDM2A	3.20e-04	21	23	2	558
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM2B KDM2A	4.20e-04	24	23	2	485
GeneFamily	PHD finger proteins	KDM2B KDM2A	5.79e-03	90	23	2	88
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRM1 BACH2 PRR7 SPTBN2	4.84e-06	163	31	4	7a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR9 TCFL5 PRM1 PRM2	5.20e-06	166	31	4	6842735750dcb361e4c9844f05233b0fbb879652
ToppCell	facs-Heart-LA-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 PRM1 PRM2 GAS1	8.15e-06	186	31	4	ed0a91f47e77fe21d4c7678d0f2a7c5f97d63dda
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 PRM1 PRM2 GAS1	8.33e-06	187	31	4	1669df899b1759c338ffce196fe009840123cfcd
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 PRM1 PRM2 GAS1	8.33e-06	187	31	4	f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KDM2B TCFL5 BACH2 PRR7	1.06e-05	199	31	4	8bc07beace200ae2ad41e932b72fdcc7ff08b812
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1-Excitatory_Neuron.Slc17a7.Fibcd1-Lypd1_(CA1_Principal_cells_(Anterior))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CACNA1F ADRA1D TCFL5	2.72e-05	84	31	3	52d167614afa9b056f2934142d3250fe5e70e806
Computational	Neighborhood of CCNA1	TCFL5 PRM1 PRM2	2.09e-04	67	19	3	GNF2_CCNA1
Computational	Neighborhood of MLF1	TCFL5 PRM1 PRM2	4.52e-04	87	19	3	GNF2_MLF1
Drug	verapamil	CACNA1F KCNG2 ADRA1D NR1I2 ADRB1 EDN2 CHRNB2	2.72e-06	490	30	7	CID000002520
Drug	brimonidine	ADRA1D ADRB1 TCFL5 CHRNB2	4.82e-06	86	30	4	CID000002435
Drug	N,N'-ethylenedimaleimide	PRM1 PRM2	5.03e-06	3	30	2	CID000237509
Drug	dixyrazine	PRM1 PRM2	5.03e-06	3	30	2	CID000017182
Drug	Cpdmea	PRM1 PRM2	5.03e-06	3	30	2	CID000129018
Drug	N-nonylsuccinimide	PRM1 PRM2	1.01e-05	4	30	2	CID000125125
Drug	Verapamil	CACNA1F ADRA1D NR1I2 ADRB1	1.07e-05	105	30	4	ctd:D014700
Drug	Br-pindolol	ADRA1D ADRB1	2.51e-05	6	30	2	CID000125847
Drug	dinonylnaphthalene	PRM1 PRM2	3.51e-05	7	30	2	CID003015220
Drug	nicardipine	CACNA1F ADRB1 EDN2 CHRNB2	3.80e-05	145	30	4	CID000004473
Drug	Epinephrine	ADRA1D ADRB1	4.68e-05	8	30	2	DB00668
Drug	ICI 118551	ADRA1D ADRB1 EDN2	5.76e-05	57	30	3	CID000003682
Drug	dapiprazole	ADRA1D ADRB1	6.01e-05	9	30	2	CID003033538
Drug	Ebiratida	PRM1 PRM2	6.01e-05	9	30	2	CID000072123
Drug	Norepinephrine	ADRA1D ADRB1	7.50e-05	10	30	2	DB00368
Drug	Droxidopa	ADRA1D ADRB1	7.50e-05	10	30	2	DB06262
Drug	DO 710	ADRA1D ADRB1	7.50e-05	10	30	2	CID003084985
Drug	L-659,066	ADRA1D ADRB1	7.50e-05	10	30	2	CID000163952
Drug	bupranolol	ADRA1D NR1I2 ADRB1	7.77e-05	63	30	3	CID000002475
Drug	AC1MIVA0	PRM1 PRM2	9.16e-05	11	30	2	CID003080575
Drug	acetylcholine	ADRA1D ADRB1 TCFL5 EDN2 CHRNB2	1.00e-04	361	30	5	CID000000187
Drug	SZL-49	ADRA1D ADRB1	1.10e-04	12	30	2	CID000004892
Drug	AC1L8V37	PRM1 PRM2	1.10e-04	12	30	2	CID000433273
Drug	DNNs	PRM1 PRM2	1.10e-04	12	30	2	CID000010226
Drug	Indoprofen [31842-01-0]; Down 200; 14.2uM; PC3; HT_HG-U133A	ADRA1D PRM2 PRR7 SPTBN2	1.18e-04	194	30	4	4249_DN
Drug	indoramin	ADRA1D ADRB1	1.30e-04	13	30	2	CID000033625
Drug	spermine	TCFL5 PRM1 PRM2 CHRNB2 SPTBN2	1.51e-04	394	30	5	CID000001103
Drug	deriglidole	ADRA1D ADRB1	1.51e-04	14	30	2	CID000065945
Drug	MK-912	ADRA1D ADRB1	1.51e-04	14	30	2	CID000123679
Drug	3-hydroxy-4-methoxycinnamic acid	ADRA1D ADRB1	1.51e-04	14	30	2	CID000092126
Drug	SKF 104078	ADRA1D ADRB1	1.74e-04	15	30	2	CID000122295
Drug	amosulalol	ADRA1D ADRB1	1.74e-04	15	30	2	CID000002169
Drug	2,4,2',4'-tetrachlorobiphenyl	NR1I2 CHRNB2	1.74e-04	15	30	2	ctd:C035976
Drug	HV723	ADRA1D ADRB1	1.74e-04	15	30	2	CID003081094
Drug	nifedipine	CACNA1F ADRA1D NR1I2 ADRB1 EDN2	1.92e-04	415	30	5	CID000004485
Drug	E-2078	PRM1 PRM2	1.99e-04	16	30	2	CID000122220
Drug	Pmbn	PRM1 PRM2	1.99e-04	16	30	2	CID000123978
Drug	fluparoxan	ADRA1D ADRB1	1.99e-04	16	30	2	CID000072036
Drug	pentobarbital	ADRA1D ADRB1 EDN2 CHRNB2	2.04e-04	224	30	4	CID000004737
Drug	cromakalim	ADRB1 TCFL5 EDN2	2.10e-04	88	30	3	CID000071191
Drug	bethanechol	ADRA1D ADRB1 CHRNB2	2.24e-04	90	30	3	CID000002370
Drug	imiloxan	ADRA1D ADRB1	2.25e-04	17	30	2	CID000133621
Drug	naftopidil	ADRA1D ADRB1	2.25e-04	17	30	2	CID000004418
Drug	Isradipine	CACNA1F NR1I2	2.53e-04	18	30	2	ctd:D017275
Drug	thymoxamine	ADRA1D ADRB1	2.53e-04	18	30	2	CID000004260
Drug	talinolol	NR1I2 ADRB1	2.53e-04	18	30	2	CID000068770
Drug	galline	PRM1 PRM2	2.53e-04	18	30	2	CID011970512
Drug	benalfocin	ADRA1D ADRB1	2.83e-04	19	30	2	CID000123981
Drug	RS-17053	ADRA1D ADRB1	2.83e-04	19	30	2	CID003894573
Drug	midaglizole	ADRA1D ADRB1	3.14e-04	20	30	2	CID000068864
Drug	naphazoline	ADRA1D ADRB1	3.14e-04	20	30	2	CID000004436
Drug	B-HT 933	ADRA1D ADRB1	3.47e-04	21	30	2	CID000002277
Drug	ARC 239	ADRA1D ADRB1	3.47e-04	21	30	2	CID000609483
Drug	DC-Chol	PRM1 PRM2	3.47e-04	21	30	2	CID000115234
Drug	6-fluoronorepinephrine	ADRA1D ADRB1	3.47e-04	21	30	2	CID000001862
Drug	benoxathian	ADRA1D ADRB1	3.81e-04	22	30	2	CID000002325
Drug	BDE-209	NR1I2 ADRB1	3.81e-04	22	30	2	CID000014410
Drug	3H-DHA	ADRA1D ADRB1	3.81e-04	22	30	2	CID000129515
Drug	silodosin	ADRA1D ADRB1	3.81e-04	22	30	2	CID005312125
Drug	labetalol	ADRA1D ADRB1	3.81e-04	22	30	2	CID000003869
Drug	arabinosyladenine	ADRA1D ADRB1 TCFL5 PRM1 EDN2 PRM2	4.11e-04	762	30	6	CID000000191
Drug	tizanidine	ADRA1D ADRB1	4.17e-04	23	30	2	CID000005487
Drug	guanethidine	ADRA1D ADRB1 CHRNB2	4.38e-04	113	30	3	CID000003518
Drug	ibopamine	ADRA1D ADRB1	4.55e-04	24	30	2	CID000068555
Drug	nipradilol	ADRA1D ADRB1	4.55e-04	24	30	2	CID000072006
Drug	epinine	ADRA1D ADRB1	4.55e-04	24	30	2	CID000004382
Drug	EN-1530	ADRA1D ADRB1 MVD CHRNB2	4.64e-04	278	30	4	CID000004425
Drug	guanfacine	ADRA1D ADRB1	4.94e-04	25	30	2	CID000003519
Drug	BRL 44408	ADRA1D ADRB1	4.94e-04	25	30	2	CID000121850
Drug	alfuzosin	ADRA1D ADRB1	4.94e-04	25	30	2	CID000002092
Drug	AC1L9XAM	PRM1 PRM2	4.94e-04	25	30	2	CID000457819
Drug	AC1L1I3V	ADRA1D ADRB1	4.94e-04	25	30	2	CID000004411
Drug	TXB2 (thromboxane B2	PRM1 EDN2 PRM2	4.97e-04	118	30	3	CID000005461
Drug	Reserpine	ADRA1D NR1I2 ADRB1	5.10e-04	119	30	3	ctd:D012110
Drug	piperoxan	ADRA1D ADRB1	5.35e-04	26	30	2	CID000006040
Drug	dibenamine	ADRA1D ADRB1	5.35e-04	26	30	2	CID000005820
Drug	L-glu-L-glu-L-glu	PRM1 PRM2	5.77e-04	27	30	2	CID000072362
Drug	AC1L1C2U	PRM1 PRM2	5.77e-04	27	30	2	CID000001716
Drug	atipamezole	ADRA1D ADRB1	5.77e-04	27	30	2	CID000071310
Drug	IBDU	ADRA1D ADRB1	5.77e-04	27	30	2	CID000022478
Drug	pimozide	CACNA1F ADRA1D ADRB1	6.16e-04	127	30	3	CID000016362
Drug	bretylium	ADRA1D ADRB1	6.21e-04	28	30	2	CID000002431
Drug	butoxamine	ADRA1D ADRB1	6.21e-04	28	30	2	CID000018026
Drug	prenalterol	ADRA1D ADRB1	6.21e-04	28	30	2	CID000042396
Drug	roxindole	ADRA1D ADRB1	6.21e-04	28	30	2	CID000219050
Drug	NSC236997	ADRB1 PRM1 EDN2 PRM2 GAS1	6.37e-04	539	30	5	CID000005300
Drug	tyramine	ADRA1D ADRB1 TCFL5	6.60e-04	130	30	3	CID000005610
Drug	tolazoline	ADRA1D ADRB1	6.67e-04	29	30	2	CID000005504
Drug	bromoacetylcholine bromide	TCFL5 CHRNB2	6.67e-04	29	30	2	CID000204966
Drug	WB4101	ADRA1D ADRB1	6.67e-04	29	30	2	CID000005685
Drug	5-methylurapidil	ADRA1D ADRB1	6.67e-04	29	30	2	CID000005640
Drug	dimethyl acetal	NR1I2 TCFL5	7.14e-04	30	30	2	CID000010795
Drug	icodextrin	ADRA1D ADRB1	7.14e-04	30	30	2	CID000003517
Drug	dihydroalprenolol	ADRA1D ADRB1	7.14e-04	30	30	2	CID000043216
Drug	S 30	PRM1 PRM2	7.14e-04	30	30	2	CID000213100
Drug	phenylpropanolamine	ADRA1D ADRB1	7.62e-04	31	30	2	CID000004786
Drug	moxonidine	ADRA1D ADRB1	7.62e-04	31	30	2	CID000004810
Drug	NSC3056	PRM1 PRM2 MVD	7.68e-04	137	30	3	CID000001599
Drug	benextramine	ADRA1D ADRB1	8.12e-04	32	30	2	CID000002317
Drug	bunazosin	ADRA1D ADRB1	8.12e-04	32	30	2	CID000002472
Disease	Diabetes Mellitus	NR1I2 ADRB1	4.23e-04	32	28	2	C0011849
Disease	Crohn's disease of the ileum	TLR9 BACH2	8.01e-04	44	28	2	C0267380
Disease	Regional enteritis	TLR9 BACH2	8.01e-04	44	28	2	C0678202
Disease	Crohn's disease of large bowel	TLR9 BACH2	8.01e-04	44	28	2	C0156147
Disease	IIeocolitis	TLR9 BACH2	8.01e-04	44	28	2	C0949272
Disease	Crohn Disease	TLR9 BACH2	1.03e-03	50	28	2	C0010346
Disease	Agents acting on the renin-angiotensin system use measurement	KDM2B ADRA1D ADRB1	3.85e-03	335	28	3	EFO_0009931
Disease	Colorectal Carcinoma	ATP11C KDM2A TLR9 SPTBN2	4.13e-03	702	28	4	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFQRLLCCARRAARR	ADRB1	386	P08588
RRRSKNRIAAQRCRK	BACH2	651	Q9BYV9
RRRRRSLPRRCQCSS	EDN2	86	P20800
RVCRRLRRANRVLRA	CACNA1F	506	O60840
LRRANRVLRARCRRA	CACNA1F	511	O60840
RRRSCQTRRRAMRCC	PRM1	26	P04553
QTRRRAMRCCRPRYR	PRM1	31	P04553
CLRRELRARCRLCRD	LONRF1	146	Q17RB8
DEARLERCCLRRLRR	KCNG2	111	Q9UJ96
RRRKLSRQLSRRERC	EHBP1L1	1506	Q8N3D4
ACLREIRCLARKRRN	MVD	81	P53602
RRCDRDSRCNLALSR	GAS1	171	P54826
ITRKTRRQCQACRLR	NR1I2	86	O75469
CSFLRRRLKRRQEER	PRR7	31	Q8TB68
VSGARRRRVRCRKCK	KDM2A	561	Q9Y2K7
ARRRRTRCRKCEACL	KDM2B	606	Q8NHM5
RFCRLETQRRLCLSR	CCN5	221	O76076
QQCLQRRRRCELRSL	PRSS56	386	P0CW18
CRLRAVLKSRRSSRC	TAS2R60	301	P59551
RQRCLERMRNSRDRL	RPAIN	26	Q86UA6
CQLSRCRRLRGVRRA	TGFBR3L	171	H3BV60
QAGDCRLRRQLRKRL	GPR150	356	Q8NGU9
RCCRRKRRNLETRNL	SLC39A5	316	Q6ZMH5
RQLQACKRREQRLRL	THAP7	256	Q9BT49
CARQRLRLRRRQRER	CHRNB2	356	P17787
RAFLRLLRCQCRRRR	ADRA1D	411	P25100
KNVRRRSARRNLSCR	ATP11C	1091	Q8NB49
RRHRRGCRTRKRTCR	PRM2	86	P04554
RALCQPMRERCRRLQ	SPTBN2	1471	O15020
RRSRYVRLRQRLCRQ	TLR9	976	Q9NR96
NRRFQLCRCLNPRAR	SPDYE18	286	P0DV79
FRRASVCRRRCRKSG	PSMD8	41	P48556
NRMERDRRRRIRICC	TCFL5	406	Q9UL49
CRRREKRRQLDARRS	ZNF692	11	Q9BU19
KRRQLDARRSKCRIR	ZNF692	16	Q9BU19