Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

3.13e-1537207GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

3.83e-1538207GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

2.70e-1311205GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.17e-1214205GO:0003964
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.18e-1121205GO:0035613
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

2.51e-1037205GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

2.88e-1038205GO:0034061
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

7.83e-1046205GO:0016893
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.26e-0879205GO:0004521
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

1.24e-07430207GO:0004175
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-8 MYO18A ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.60e-07262206GO:0140097
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.94e-07136205GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.94e-07136205GO:0004519
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

3.38e-07152205GO:0016779
GeneOntologyMolecularFunctionpeptidase activity

ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

2.09e-06654207GO:0008233
GeneOntologyMolecularFunctionnuclease activity

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

2.67e-06231205GO:0004518
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

1.60e-05891207GO:0005198
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-8 MYO18A ERVK-11 ERVK-6 ERVK-7 ERVK-10

2.92e-05645206GO:0140640
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

4.64e-05417205GO:0140098
GeneOntologyMolecularFunctionzinc ion binding

ERVK-8 ERVK-11 ERVK-6 ERVK-19 ERVK-7 ERVK-10

1.76e-04891206GO:0008270
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-8 ERVK-11 ERVK-6 FKTN ERVK-7 ERVK-10

2.32e-04938206GO:0016772
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-8 ERVK-11 ERVK-6 ERVK-19 ERVK-7 ERVK-10

8.27e-041189206GO:0046914
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

9.95e-04807205GO:0016788
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TMEM94 SCN11A TRPC4

1.07e-02465203GO:0046873
GeneOntologyBiologicalProcessDNA integration

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

8.38e-1313215GO:0015074
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

RRM1 ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

6.07e-1248216GO:0000731
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.81e-0883215GO:0006278
GeneOntologyBiologicalProcessDNA-templated DNA replication

RRM1 ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

1.85e-08178216GO:0006261
GeneOntologyBiologicalProcessDNA biosynthetic process

RRM1 ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

6.18e-08218216GO:0071897
GeneOntologyBiologicalProcessDNA replication

RRM1 ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

5.12e-07312216GO:0006260
GeneOntologyBiologicalProcessDNA recombination

ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

2.83e-05368215GO:0006310
GeneOntologyBiologicalProcessDNA repair

RRM1 ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

3.41e-05648216GO:0006281
GeneOntologyBiologicalProcessDNA metabolic process

RRM1 ERVK-8 MYO18A ERVK-11 ERVK-6 ERVK-7 ERVK-10

6.47e-051081217GO:0006259
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-8 ERVK-6 ERVK-19

8.51e-0585213GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-8 ERVK-6 ERVK-19

8.51e-0585213GO:0000768
GeneOntologyBiologicalProcessviral process

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-10

8.52e-05464215GO:0016032
GeneOntologyBiologicalProcesssyncytium formation

ERVK-8 ERVK-6 ERVK-19

9.76e-0589213GO:0006949
GeneOntologyBiologicalProcessDNA damage response

RRM1 ERVK-8 ERVK-11 ERVK-6 ERVK-7 ERVK-10

2.96e-04959216GO:0006974
DomainIon_trans_dom

SCN11A TRPC4

3.20e-03114142IPR005821
DomainIon_trans

SCN11A TRPC4

3.20e-03114142PF00520
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-18 ERVK-8 ERVK-11 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

4.15e-169421821542922
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-18 ERVK-6 ERVK-19 ERVK-7

4.91e-13521412629516
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-18 ERVK-6 ERVK-19

1.90e-10321310516026
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-18 ERVK-11 ERVK-25 ERVK-10

2.99e-101821418664271
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10

7.59e-10421310469592
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19 ERVK-10

7.59e-1042137983737
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-6 ERVK-19

4.16e-081221314557543
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

3.47e-0722129460924
Pubmed

Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.

ERVK-18 ERVK-6

3.47e-07221211672541
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

3.47e-0722129060628
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-11 ERVK-6

1.04e-0632129971820
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

3.47e-06521211401426
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19

5.20e-06621215063128
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19

1.56e-051021212970426
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RRM1 SCN11A IL21R

1.21e-051591332233fee5dcdb6c7dee5b1bd8efbc07d86b339927
Diseasebody composition measurement

SNAP47 TRPC4

3.68e-03193142EFO_0005106

Protein segments in the cluster

PeptideGeneStartEntry
SPQWLRSKWWTIKRQ

DMTF1

376

Q9Y222
DKQAKKKWIWGPSGW

PADI6

141

Q6TGC4
RLKKFPWSLWVWTTD

LOXHD1

421

Q8IVV2
PWSLWVWTTDLKKAG

LOXHD1

426

Q8IVV2
DRPELPWWKCKKWAL

IPO7

251

O95373
VKDWPWWKLFTTVRP

MYO18A

1231

Q92614
LTWKTEKPVWVNQWP

HERVK_113

26

P63132
LTWKTEKPVWVNQWP

ERVK-7

26

P63135
LTWKTEKPVWVNQWP

ERVK-6

26

Q9BXR3
LTWKTEKLVWVNQWP

ERVK-18

26

Q9QC07
KWKGWPPKYSTWEPE

CBX7

31

O95931
TWKIPVKTWDWKRSP

FKTN

426

O75072
WRLWKKIWAVPSPER

IL21R

261

Q9HBE5
LESPAWWPFSSKLWK

SNAP47

216

Q5SQN1
WWPFSSKLWKTPPET

SNAP47

221

Q5SQN1
LTWKTEKPVWVNQWP

ERVK-25

26

P63136
WNVTPTDLWDWKVLK

RRM1

571

P23921
KPLWRKSPLTNLWWA

TMEM94

1256

Q12767
LTWKTEKPVWVNQWP

ERVK-10

26

P10266
LTWKTEKLVWVNQWP

ERVK-8

26

P63133
LTWKTEKPVWVNQWP

ERVK-11

26

Q9UQG0
SVDKRKPPWVIWWNL

SCN11A

1031

Q9UI33
LTWKTEKPVWVNQWP

ERVK-19

26

Q9WJR5
PSPKSLWYLIKWIWT

TRPC4

661

Q9UBN4