Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	RNA secondary structure unwinding	AGO2 DDX39B DHX9	7.07e-06	9	92	3	GO:0010501
GeneOntologyCellularComponent	centrosome	RABL6 ABRAXAS2 ACTR1A AHI1 PLEKHG6 RAP1GAP2 MAP3K11 FLCN BRSK1 CSPP1 PLK4 DYNC1H1 DHX9 PCNT	8.54e-06	770	94	14	GO:0005813
GeneOntologyCellularComponent	TRAPPIII protein complex	TRAPPC12 TRAPPC2B TRAPPC2	1.88e-05	12	94	3	GO:1990072
GeneOntologyCellularComponent	TRAPP complex	TRAPPC12 TRAPPC2B TRAPPC2	5.72e-05	17	94	3	GO:0030008
GeneOntologyCellularComponent	microtubule organizing center	RABL6 ABRAXAS2 ACTR1A AHI1 PLEKHG6 RAP1GAP2 MAP3K11 FLCN BRSK1 CSPP1 PLK4 DYNC1H1 DHX9 PCNT	6.01e-05	919	94	14	GO:0005815
GeneOntologyCellularComponent	axon	TANC2 LRIG2 ATP6AP2 AVIL HCN3 LRP2 SYNPO LRRC7 BRSK1 KCNIP3 DYNC1H1 PNOC CD200	1.73e-04	891	94	13	GO:0030424
GeneOntologyCellularComponent	manchette	ACTR1A SPEF2 DYNC1H1	2.66e-04	28	94	3	GO:0002177
GeneOntologyCellularComponent	dendrite	SHANK1 SHISA9 TANC2 AGO2 ATP6AP2 HCN3 LRP2 SYNPO LRRC7 ARHGEF2 KCNIP3 PNOC	4.59e-04	858	94	12	GO:0030425
GeneOntologyCellularComponent	dendritic tree	SHANK1 SHISA9 TANC2 AGO2 ATP6AP2 HCN3 LRP2 SYNPO LRRC7 ARHGEF2 KCNIP3 PNOC	4.68e-04	860	94	12	GO:0097447
GeneOntologyCellularComponent	endoribonuclease complex	AGO2 POP1 DHX9	6.12e-04	37	94	3	GO:1902555
GeneOntologyCellularComponent	nuclear outer membrane	GUCY2D TRAPPC2B TRAPPC2	7.71e-04	40	94	3	GO:0005640
GeneOntologyCellularComponent	dendritic spine	SHANK1 SHISA9 TANC2 ATP6AP2 SYNPO LRRC7	7.88e-04	242	94	6	GO:0043197
GeneOntologyCellularComponent	neuron spine	SHANK1 SHISA9 TANC2 ATP6AP2 SYNPO LRRC7	8.76e-04	247	94	6	GO:0044309
GeneOntologyCellularComponent	RISC-loading complex	AGO2 DHX9	8.79e-04	10	94	2	GO:0070578
GeneOntologyCellularComponent	endonuclease complex	AGO2 POP1 DHX9	9.54e-04	43	94	3	GO:1905348
GeneOntologyCellularComponent	somatodendritic compartment	SHANK1 SHISA9 TANC2 AGO2 ATP6AP2 HCN3 LRP2 SYNPO LRRC7 ARHGEF2 KCNIP3 DYNC1H1 PNOC CD200	1.15e-03	1228	94	14	GO:0036477
GeneOntologyCellularComponent	TRAPPII protein complex	TRAPPC2B TRAPPC2	1.28e-03	12	94	2	GO:1990071
GeneOntologyCellularComponent	MKS complex	AHI1 CC2D2A	1.76e-03	14	94	2	GO:0036038
Domain	2Fe2S_fd_BS	AOX1 NDUFS1	2.53e-04	5	95	2	IPR006058
Domain	2FE2S_FER_1	AOX1 NDUFS1	2.53e-04	5	95	2	PS00197
Domain	Fer2	AOX1 NDUFS1	3.79e-04	6	95	2	PF00111
Domain	2FE2S_FER_2	AOX1 NDUFS1	3.79e-04	6	95	2	PS51085
Domain	2Fe-2S_ferredoxin-type	AOX1 NDUFS1	3.79e-04	6	95	2	IPR001041
Domain	LRRCT	LRIG2 LRIG3 LRIG1	5.68e-04	32	95	3	PF01463
Domain	FAD-dep_OxRdtase	PDPR KMO	1.63e-03	12	95	2	IPR006076
Domain	DAO	PDPR KMO	1.63e-03	12	95	2	PF01266
Domain	LRR_8	LRIG2 LRIG3 LRCH2 LRIG1 LRRC7	1.81e-03	171	95	5	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRIG2 LRIG3 LRCH2 LRIG1 LRRC7	2.10e-03	177	95	5	IPR003591
Domain	LRR_TYP	LRIG2 LRIG3 LRCH2 LRIG1 LRRC7	2.10e-03	177	95	5	SM00369
Domain	Beta-grasp_dom	AOX1 NDUFS1	2.24e-03	14	95	2	IPR012675
Domain	-	AOX1 NDUFS1	2.24e-03	14	95	2	3.10.20.30
Domain	CysPc	ADGB CAPN14	2.57e-03	15	95	2	SM00230
Domain	Peptidase_C2_calpain_cat	ADGB CAPN14	2.57e-03	15	95	2	IPR001300
Domain	Peptidase_C2	ADGB CAPN14	2.57e-03	15	95	2	PF00648
Domain	CALPAIN_CAT	ADGB CAPN14	2.57e-03	15	95	2	PS50203
Domain	Leu-rich_rpt	LRIG2 LRIG3 LRCH2 LRIG1 CARMIL1 LRRC7	2.61e-03	271	95	6	IPR001611
Domain	LRR	LRIG2 LRIG3 LRCH2 LRIG1 LRRC7	3.64e-03	201	95	5	PS51450
Domain	Pkinase_Tyr	KSR1 GUCY2D MAP3K11 PLK4	4.26e-03	129	95	4	PF07714
Domain	LRR_1	LRIG2 LRIG3 LRCH2 LRIG1 LRRC7	5.22e-03	219	95	5	PF00560
Domain	Ser-Thr/Tyr_kinase_cat_dom	KSR1 GUCY2D MAP3K11 PLK4	5.41e-03	138	95	4	IPR001245
Domain	-	LRIG2 LRIG3 LRCH2 LRIG1 CARMIL1 LRRC7	5.95e-03	321	95	6	3.80.10.10
Pathway	REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE	ACTR1A AHI1 CC2D2A PLK4 DYNC1H1 PCNT	1.15e-05	97	74	6	M27478
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 TANC2 LRIG2 ACTR1A BCL11B AGO2 LRCH2 DOCK11 HCN3 SYNPO LRRC7 ARHGEF2 CCDC6 BRSK1 DYNC1H1 PCNT	8.81e-09	963	96	16	28671696
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 RABL6 ACTR1A TPST2 THADA ACACA TRAPPC12 MTMR8 RAP1GAP2 MAP3K11 FLCN PPARA ATG2A MLXIP ARHGEF2 DYNC1H1 PCNT	8.91e-09	1105	96	17	35748872
Pubmed	Redistribution of LRIG proteins in psoriasis.	LRIG2 LRIG3 LRIG1	2.04e-08	3	96	3	18037903
Pubmed	LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers.	LRIG2 LRIG3 LRIG1	2.04e-08	3	96	3	27628597
Pubmed	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.	LRIG2 LRIG3 LRIG1	2.04e-08	3	96	3	33469151
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SHANK1 TANC2 ACTR1A AGO2 LRCH2 CLCN6 LRIG1 CARMIL1 SYNPO LRRC7 MCAT ARHGEF2 BRSK1 DDX39B NDUFS1 DYNC1H1 DHX9	3.62e-07	1431	96	17	37142655
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	LRCH2 ACACA DOCK11 USP11 POP1 ARHGEF2 CCDC6 MED27 DDX39B DHX9	4.06e-07	440	96	10	34244565
Pubmed	Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.	LRIG2 LRIG3 LRIG1	1.13e-06	8	96	3	26651291
Pubmed	In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.	LRIG2 LRIG3 LRIG1	1.13e-06	8	96	3	24086156
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	LRIG2 LRIG3 LRIG1 TRAPPC12 ATP6AP2 TRABD LRP2 FLCN ATG2A TRAPPC2	1.38e-06	504	96	10	34432599
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	TANC2 ACTR1A KSR1 AHI1 LRCH2 BRSK1	1.87e-06	132	96	6	16944949
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	ACTR1A RAP1GAP2 CSPP1 PLK4 DYNC1H1 PCNT	3.35e-06	146	96	6	21399614
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	ACTR1A AGO2 LRCH2 ACACA CARMIL1 LRP2 ATG2A MLXIP ARHGEF2 FHIP2A DYNC1H1 PCNT	4.16e-06	853	96	12	28718761
Pubmed	The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea.	LRIG2 LRIG3	7.54e-06	2	96	2	15203213
Pubmed	Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.	LRIG2 LRIG1	7.54e-06	2	96	2	21632100
Pubmed	Down-regulation of leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) in HP75 pituitary adenoma cell line.	LRIG2 LRIG3	7.54e-06	2	96	2	17393120
Pubmed	Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma.	LRIG3 LRIG1	7.54e-06	2	96	2	23165628
Pubmed	Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.	TRAPPC2B TRAPPC2	7.54e-06	2	96	2	14597397
Pubmed	Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.	TRAPPC2B TRAPPC2	7.54e-06	2	96	2	10431248
Pubmed	Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression.	LRIG2 LRIG1	7.54e-06	2	96	2	22484910
Pubmed	Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma.	LRIG2 LRIG3	7.54e-06	2	96	2	34839782
Pubmed	Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400).	TRAPPC2B TRAPPC2	7.54e-06	2	96	2	12939648
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ACACA LRIG1 DOCK11 POP1 DDX39B NDUFS1 CD200 DHX9	7.78e-06	363	96	8	14691545
Pubmed	TRAPP Complexes in Secretion and Autophagy.	TRAPPC12 TRAPPC2B TRAPPC2	9.05e-06	15	96	3	27066478
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	SHANK1 ACTR1A BCL11B ATP6AP2 U2SURP SYNPO SF3A2 NDUFS1 DHX9	1.28e-05	513	96	9	25798074
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRIG3 LRCH2 RAP1GAP2 LRRC7 MLXIP FHIP2A DYNC1H1 PCNT	1.77e-05	407	96	8	12693553
Pubmed	The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.	ACTR1A PLK4 DYNC1H1 PCNT	1.79e-05	56	96	4	11076968
Pubmed	The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.	ACTR1A PLK4 DYNC1H1 PCNT	1.92e-05	57	96	4	16462731
Pubmed	Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.	ACTR1A PLK4 DYNC1H1 PCNT	2.06e-05	58	96	4	12852856
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ACTR1A KSR1 THADA LRCH2 WDHD1 USP42 TRAPPC12 HCN3 SYNPO NDUFS1	2.13e-05	689	96	10	36543142
Pubmed	ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis.	ACACA PPARA	2.26e-05	3	96	2	38395901
Pubmed	Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle.	PLEKHG6 CSPP1	2.26e-05	3	96	2	19129481
Pubmed	ADGB variants cause asthenozoospermia and male infertility.	ADGB SPEF2	2.26e-05	3	96	2	36995441
Pubmed	Hepatic Ago2 Regulates PPARα for Oxidative Metabolism Linked to Glycemic Control in Obesity and Post Bariatric Surgery.	AGO2 PPARA	2.26e-05	3	96	2	33567453
Pubmed	Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function.	LRP2 PPARA	2.26e-05	3	96	2	21311715
Pubmed	TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.	TRAPPC12 TRAPPC2	2.26e-05	3	96	2	25918224
Pubmed	Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).	AGO2 DHX9	2.26e-05	3	96	2	23361462
Pubmed	Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.	ACTR1A PLK4 DYNC1H1 PCNT	2.52e-05	61	96	4	7790358
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 KSR1 ACACA DOCK11 CARMIL1 MLXIP ARHGEF2 CCDC6 CSPP1 PLK4 DOP1A	2.61e-05	861	96	11	36931259
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TANC2 ABRAXAS2 KSR1 LRCH2 DOCK11 ARHGEF2 CCDC6 CSPP1	3.40e-05	446	96	8	24255178
Pubmed	Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.	ACTR1A PLK4 DYNC1H1 PCNT	3.45e-05	66	96	4	12221128
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TANC2 ACTR1A U2SURP ARHGEF2 SF3A2 DDX39B DYNC1H1 DHX9 PCNT	3.45e-05	582	96	9	20467437
Pubmed	Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.	ACACA NFE2L1 MCAT PPARA	3.66e-05	67	96	4	16806233
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPEF2 AVIL U2SURP CC2D2A SYNPO PPARA ARHGEF2 EPX SF3A2 DDX39B NDUFS1 DOP1A PCNT TRAPPC2	4.15e-05	1442	96	14	35575683
Pubmed	A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.	TRAPPC2B TRAPPC2	4.51e-05	4	96	2	11134351
Pubmed	The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.	KSR1 ARHGEF2	4.51e-05	4	96	2	24525234
Pubmed	CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.	AGO2 DHX9	4.51e-05	4	96	2	19955415
Pubmed	Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.	ACACA PPARA	4.51e-05	4	96	2	11254743
Pubmed	Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.	BCL11B NR2F1	4.51e-05	4	96	2	10744719
Pubmed	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.	BCL11B NRAP NR2F1	5.68e-05	27	96	3	37995181
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TANC2 ACTR1A KSR1 NAT14 THADA AHI1 LRCH2 CARMIL1 CSPP1 NDUFS1 DYNC1H1 PGM3 DHX9	6.98e-05	1321	96	13	27173435
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	SHANK1 SYNPO LRRC7	7.07e-05	29	96	3	19208628
Pubmed	RNA helicase A interacts with RISC in human cells and functions in RISC loading.	AGO2 DHX9	7.50e-05	5	96	2	17531811
Pubmed	Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).	LRIG3 LRIG1	7.50e-05	5	96	2	23723069
Pubmed	A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.	PPARA NR2F1	7.50e-05	5	96	2	9177236
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	ACTR1A LRCH2 WDHD1 U2SURP POP1 SF3A2 DDX39B DYNC1H1	8.22e-05	506	96	8	30890647
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RABL6 ACACA WDHD1 U2SURP POP1 MCAT CCDC6 SF3A2 DHX9	8.33e-05	653	96	9	33742100
Pubmed	Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.	BCL11B NR2F1 PNOC	9.54e-05	32	96	3	36596814
Pubmed	saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.	AGO2 DHX9	1.12e-04	6	96	2	26902284
Pubmed	Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.	PLK4 PCNT	1.12e-04	6	96	2	25503564
Pubmed	The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.	PLK4 PCNT	1.12e-04	6	96	2	18207742
Pubmed	Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.	ACTR1A DYNC1H1	1.12e-04	6	96	2	11483508
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRIG2 LRIG3 LRIG1	1.15e-04	34	96	3	18848646
Pubmed	Joubert Syndrome	AHI1 CC2D2A CSPP1	1.15e-04	34	96	3	20301500
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	ACTR1A ACACA WDHD1 DOCK11 POP1 CCDC6 DYNC1H1	1.23e-04	399	96	7	37536630
Pubmed	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.	ACTR1A ACACA POP1 SF3A2 DYNC1H1 DHX9	1.33e-04	281	96	6	26725010
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	TANC2 RABL6 ABRAXAS2 KSR1 WDHD1 PDE8B RAP1GAP2 ATG2A MLXIP CCDC6 FHIP2A	1.39e-04	1038	96	11	26673895
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	ACACA U2SURP POP1 NDUFS1 DHX9	1.54e-04	182	96	5	32239614
Pubmed	Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.	BCL11B ARHGEF2	1.57e-04	7	96	2	28453519
Pubmed	CoupTFI interacts with retinoic acid signaling during cortical development.	BCL11B NR2F1	1.57e-04	7	96	2	23472160
Pubmed	Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.	LRIG3 LRIG1	1.57e-04	7	96	2	20126551
Pubmed	Functional organization of the yeast proteome by systematic analysis of protein complexes.	TRAPPC2B TRAPPC2	1.57e-04	7	96	2	11805826
Pubmed	A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.	LRIG2 LRIG3	1.57e-04	7	96	2	20446891
Pubmed	A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.	LRP2 PCNT	1.57e-04	7	96	2	15314648
Pubmed	The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.	ABRAXAS2 DYNC1H1	1.57e-04	7	96	2	26195665
Pubmed	Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.	LRIG3 BCL11B CDH4	1.60e-04	38	96	3	30240734
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ACTR1A AGO2 ACACA U2SURP POP1 ARHGEF2 MED27 SF3A2 DDX39B NDUFS1 DYNC1H1 DHX9	1.67e-04	1247	96	12	27684187
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	USP42 CSPP1 PLK4 PCNT	1.81e-04	101	96	4	24613305
Pubmed	Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda.	TRAPPC2B TRAPPC2	2.09e-04	8	96	2	11031107
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	KLHL6 ACTR1A KSR1 AGO2 MAP3K11 FLCN ARHGEF2 CCDC6 BRSK1 PLK4	2.12e-04	910	96	10	36736316
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TANC2 ABRAXAS2 LRCH2 PLEKHG6 DOCK11 PPP2R3B MCAT ARHGEF2 CCDC6 SF3A2	2.24e-04	916	96	10	32203420
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SHISA9 THADA AGO2 ACACA DHRS3 CARMIL1 SYNPO LRRC7 PPARA KCNIP3 MED27 DOP1A PCNT	2.28e-04	1489	96	13	28611215
Pubmed	CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.	DCAF10 USP11 NDUFS1 PGM3	2.34e-04	108	96	4	30166453
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TANC2 LRIG3 KSR1 THADA BCL11B AGO2 USP11 TRABD CECR2 AOX1 LRP2	2.59e-04	1116	96	11	31753913
Pubmed	Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.	LRIG3 LRIG1	2.68e-04	9	96	2	19004851
Pubmed	Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK.	MAP3K11 PPARA	2.68e-04	9	96	2	26947074
Pubmed	Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury.	ACACA PPARA	2.68e-04	9	96	2	27746183
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RABL6 ACACA ZCCHC10 USP42 U2SURP POP1 ARHGEF2 SF3A2 DDX39B NDUFS1 DYNC1H1 DHX9	2.77e-04	1318	96	12	30463901
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NAT14 THADA LRIG1 ATP6AP2 TRABD FAM20B ARHGEF2 NR2F1 DYNC1H1 PGM3	2.79e-04	942	96	10	31073040
Pubmed	SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex.	BCL11B PCNT	3.34e-04	10	96	2	25088364
Pubmed	Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications.	BCL11B NR2F1	3.34e-04	10	96	2	26814051
Pubmed	Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.	LRIG1 USP42 CARMIL1	3.42e-04	49	96	3	24652767
Pubmed	Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain.	AVIL CD200	4.08e-04	11	96	2	34921782
Pubmed	Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.	LRIG3 LRIG1	4.08e-04	11	96	2	34338291
Pubmed	Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex.	BCL11B PCNT	4.08e-04	11	96	2	31794381
Pubmed	Loci at chromosomes 13, 19 and 20 influence age at natural menopause.	BRSK1 DYNC1H1	4.08e-04	11	96	2	19448619
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	FAM20B ATG2A PCNT	4.08e-04	52	96	3	9455477
Pubmed	Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.	BCL11B KCNIP3 CDH4	4.32e-04	53	96	3	27210758
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 LRIG2 ABRAXAS2 ZBTB34 THADA POP1 DOP1A	4.44e-04	493	96	7	15368895
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	ABRAXAS2 USP42 USP11 ATP6AP2 ATG2A ARHGEF2 CCDC6 SF3A2 NDUFS1 TRAPPC2	4.64e-04	1005	96	10	19615732
Interaction	TOP3B interactions	TANC2 RABL6 ACTR1A TPST2 THADA AGO2 ACACA TRAPPC12 ATP6AP2 MTMR8 RAP1GAP2 MAP3K11 FLCN PPARA ATG2A MLXIP ARHGEF2 DDX39B DYNC1H1 DHX9 PCNT	3.76e-06	1470	95	21	int:TOP3B
Cytoband	1q25	FAM20B DHX9	1.36e-03	26	96	2	1q25
Cytoband	12q14.1	LRIG3 AVIL	1.58e-03	28	96	2	12q14.1
GeneFamily	Trafficking protein particle complex	TRAPPC12 TRAPPC2	1.20e-03	14	67	2	772
GeneFamily	C2 domain containing\|Calpains	ADGB CAPN14	1.38e-03	15	67	2	975
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_k-means-cluster#1_top-relative-expression-ranked_1000	PDPR ACACA CARMIL1 CSPP1 SF3A2 PGM3	1.24e-05	114	95	6	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_k1_1000
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SHISA9 DOCK11 TMEM132E CDH4 PNOC	6.51e-06	121	96	5	7f2057367777c6c92f596054cbc5fe567d079fbc
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGO2 LRCH2 NFE2L1 POP1 PPARA	7.05e-06	123	96	5	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHISA9 LRIG3 DOCK11 PNOC CD200	3.36e-05	170	96	5	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AHI1 BCL11B DOCK11 CD200 PCNT	3.36e-05	170	96	5	3ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLAMF8 CLCN6 CARMIL1 KCNIP3 KMO	3.55e-05	172	96	5	b043d4f81dced7fb3326043f68474123be47cc5d
ToppCell	facs-Lung-nan-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL11B PLEKHG6 LRIG1 ZCCHC10 ATG2A	3.76e-05	174	96	5	1c073177c1753e3b91ef8fd9e95230a1d13c82f3
ToppCell	facs-Lung-nan-3m-Lymphocytic-CD8+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL11B PLEKHG6 LRIG1 ZCCHC10 ATG2A	3.76e-05	174	96	5	5491ad5c144baf2ef9b1c58eb720c872d14feb15
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	LRIG2 DOCK11 PDE8B ATG2A FHIP2A	3.86e-05	175	96	5	2812ac2ef41d245db544697fb6da1883361c96e8
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	NAT14 THADA AHI1 AGO2 CD200	3.97e-05	176	96	5	56c055488e34605d32562571a2fee621b47c9441
ToppCell	PBMC-Mild-cDC_11\|Mild / Compartment, Disease Groups and Clusters	SLAMF8 TANC2 CARMIL1 SERPINF2 CD200	4.07e-05	177	96	5	974305e4c0eff90134c4e58cf11b955d1eee0501
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	TANC2 ACACA CECR2 LRP2 ABCC9	4.41e-05	180	96	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	ACACA DHRS3 DOCK11 PDE8B PPARA	4.77e-05	183	96	5	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	3'_v3-GI_small-bowel-Myeloid_Dendritic-DC1\|GI_small-bowel / Manually curated celltypes from each tissue	SLAMF8 NALCN TMEM132E CECR2 SERPINF2	4.90e-05	184	96	5	8e393eea7240584a3cef718bee094e2705ec1891
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SHANK1 GPR61 NALCN HCN3 RAP1GAP2	5.29e-05	187	96	5	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CUTC ACACA POP1 MCAT KCNIP3	5.43e-05	188	96	5	c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	KSR1 CECR2 BRSK1 NR2F1 CD200	5.56e-05	189	96	5	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	THADA BCL11B USP42 CCDC6 FHIP2A	5.70e-05	190	96	5	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BCL11B SPEF2 POP1 ATG2A CCDC6	5.70e-05	190	96	5	69c5c4d5f4fb6e5ae2c9dbf9d209faf093c3f769
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRIG3 LRCH2 SYNPO CDH4 NR2F1	5.85e-05	191	96	5	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TANC2 ACACA CECR2 LRP2 ABCC9	6.14e-05	193	96	5	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TANC2 ACACA CECR2 LRP2 ABCC9	6.14e-05	193	96	5	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Cortical_neuron\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	USP11 ABCC9 CD200	6.39e-05	36	96	3	25fd4cf19f2ed94f99600c18383b17f86bb17ef5
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KLHL6 ADGB SPEF2 CC2D2A CSPP1	6.45e-05	195	96	5	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KLHL6 ADGB SPEF2 CC2D2A CSPP1	6.77e-05	197	96	5	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KLHL6 ADGB SPEF2 CC2D2A CSPP1	6.77e-05	197	96	5	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 ACACA CECR2 LRP2 ABCC9	6.93e-05	198	96	5	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 ACACA LRIG1 CECR2 LRP2	6.93e-05	198	96	5	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TANC2 AHI1 TRABD CECR2 PGM3	7.27e-05	200	96	5	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
Disease	X-linked spondyloepiphyseal dysplasia tarda (implicated_via_orthology)	TRAPPC2B TRAPPC2	1.00e-05	2	94	2	DOID:0080362 (implicated_via_orthology)
Disease	gout	CARMIL1 LRP2 MAP3K11 ABCC9 MLXIP MED27	3.99e-05	196	94	6	EFO_0004274
Disease	Intellectual Disability	TANC2 RABL6 AHI1 BCL11B LRP2 FHIP2A DYNC1H1 PGM3	9.30e-05	447	94	8	C3714756
Disease	Eye Diseases, Hereditary	LRP2 PLK4	1.49e-04	6	94	2	C0015398
Disease	spondyloepiphyseal dysplasia congenita (implicated_via_orthology)	TRAPPC2B TRAPPC2	1.49e-04	6	94	2	DOID:14789 (implicated_via_orthology)
Disease	Joubert syndrome (implicated_via_orthology)	AHI1 CC2D2A	2.09e-04	7	94	2	DOID:0050777 (implicated_via_orthology)
Disease	response to carboplatin, response to antineoplastic agent	LRIG1 SPEF2	4.44e-04	10	94	2	GO_0097327, GO_0097328
Disease	Meckel-Gruber syndrome	CC2D2A CSPP1	1.03e-03	15	94	2	C0265215
Disease	Meckel syndrome type 1	CC2D2A CSPP1	1.49e-03	18	94	2	C3714506
Disease	Familial aplasia of the vermis	AHI1 CC2D2A	1.84e-03	20	94	2	cv:C0431399
Disease	Joubert syndrome 1	AHI1 CSPP1	2.03e-03	21	94	2	C4551568
Disease	Seckel syndrome	PLK4 PCNT	2.23e-03	22	94	2	C0265202
Disease	Down syndrome (is_marker_for)	ACTR1A PCNT	2.23e-03	22	94	2	DOID:14250 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DHVMFRMGLLAVLRS	PGM3	36	O95394
VRMGTEPRHFMAIFK	AVIL	476	O75366
SHSRMERSVFMPRPQ	ABRAXAS2	321	Q15018
PEQTHRLARAMMAFT	SERPINF2	76	P08697
RTDRLKSDFMISHPM	AHI1	351	Q8N157
RMTPFTIPTEMHFVR	ADGB	516	Q8N7X0
DMRRDVQEIFRMTPH	DDX39B	206	Q13838
IMTRLFRTGMLEELH	ARHGEF2	256	Q92974
NPRHMEMYADRESRG	ACACA	2101	Q13085
FHMSQATRPDMIRIL	DOP1A	256	Q5JWR5
RRESRHLHLFMPAVM	ABCC9	96	O60706
EIDSPENMMRHIRFL	CCDC6	251	Q16204
RTIDMSFLHFPCSMR	AADACL3	381	Q5VUY0
QPRTLGHVMDSRVMR	CECR2	821	Q9BXF3
SERMPRRAHSNMLTI	ATG2A	1546	Q2TAZ0
ALDVVMRHLPSMRYT	AGO2	161	Q9UKV8
FMELDAGSRLVMHLR	ALG1L	6	Q6GMV1
GPRLQMDFVSFIHLM	CAPN14	636	A8MX76
RELRMPMSNVHLRGT	AOX1	1061	Q06278
MSRDEHRARAMKIPF	NFE2L1	611	Q14494
TFARFPHERATMDDM	PPP2R3B	151	Q9Y5P8
FLEMMEARSRGHASP	RABL6	271	Q3YEC7
PMSADRVVAFMDHIR	NR2F1	286	P10589
MFRVARVAAMQHGPL	GPR61	231	Q9BZJ8
PRMHEFQSEVFMIIG	KLHL6	311	Q8WZ60
PAARERRMHVMPDDD	LRIG1	641	Q96JA1
RRMHVMPDDDVFFIT	LRIG1	646	Q96JA1
HMRQVLGAPSFRMLA	FLCN	351	Q8NFG4
TRFHLPMDMVNIRHA	NRAP	626	Q86VF7
ILSAVGTFRMRHMPE	GUCY2D	956	Q02846
IRFRFMGIENIHVMR	MTMR8	266	Q96EF0
SATEMAMFRRVNEPH	LRRC7	1121	Q96NW7
GTDFPAARERRMHVM	LRIG3	641	Q6UXM1
SRDLVPRIYEMMGHV	B3GALNT1	246	O75752
MAPSHLSVREMREDE	NAT14	1	Q8WUY8
MRFDLSHGSPQMVRR	KSR1	326	Q8IVT5
SRTFLRHRVMEVMPL	PDPR	426	Q8NCN5
RFGHTMLQPFMFRLD	EPX	471	P11678
RRYPSMARIHSMTIE	PDE8B	436	O95263
ERNPMDIFDMARHRL	CSPP1	976	Q1MSJ5
FHTRFLMRMRLTPDC	DCAF10	296	Q5QP82
HPRIERASMDGSMRT	LRP2	1576	P98164
ISRIDRMFPEMSIHL	MED27	166	Q6P2C8
HFNAVLEEFPMMRRA	HCN3	521	Q9P1Z3
SHMRESFLMSPESVR	PCNT	1236	O95613
EMQHLRRMPRVRSLF	PNOC	91	Q13519
MERLVIRMPFSHLST	CD200	1	P41217
RMLPVSGAFHTRLME	MCAT	261	Q8IVS2
VFQTLPRHMRRRAMS	POP1	131	Q99575
TMEMNRFRLIGPLSH	POP1	426	Q99575
LEVRLHTFSMFGMPR	PLEKHG6	106	Q3KR16
GHTSLRPMRAEDMLR	PLEKHG6	726	Q3KR16
VPVTRRQFDHMKDMF	MLXIP	806	Q9HAP2
GNLFHRPRATVMVMV	ATP6AP2	66	O75787
TMEERFRPLTFHGLI	CLCN6	731	P51797
NMERFLHAIMPSTFI	KMO	381	O15229
HPSAFDRVMRLNPMA	BCL11B	341	Q9C0K0
HDRLQMEREMLFIPS	CC2D2A	276	Q9P2K1
SLERSMHPELMKYGR	DOCK11	306	Q5JSL3
SGRMYVTRPMDREEH	CDH4	226	P55283
MPHSIMRIDIAGRDV	ACTR1A	176	P61163
FHRRKMQVPTAEEMS	BRSK1	566	Q8TDC3
RAFDMVHDPMAALET	CUTC	146	Q9NTM9
FRPDRLLAMAHMFVS	DYNC1H1	3996	Q14204
SRMLRPVSRAFEMEF	CARMIL1	926	Q5VZK9
VHERFFIGVMEPQLM	FHIP2A	386	Q5W0V3
DMMGRHTYPILREDA	KCNIP3	196	Q9Y2W7
AQVLREMPRDSFHSM	MAP3K11	381	Q16584
HTSTEMFQGMRVRFP	DHRS3	221	O75911
RFERLETHMTPEMFR	DHX9	781	Q08211
PGFTMRRKMEHLREE	LRCH2	631	Q5VUJ6
MSHNAIRFGRMPRSE	PPARA	166	Q07869
VSGREDRPFRMMLHA	RPUSD1	196	Q9UJJ7
MKSDTFQERLRHMIP	SPEF2	131	Q9C093
RHMIPRQTDFNLMRI	SPEF2	141	Q9C093
HSREMAARALVPFVM	THADA	1361	Q6YHU6
FRDREIMFHVSTKLP	RAP1GAP2	326	Q684P5
FMRVGDPRVAHMVDS	TMEM132E	631	Q6IEE7
RTGEVMRILPRMHED	NDUFS1	266	P28331
SQMERSPMLERRHFG	SYNPO	496	Q8N3V7
PQREHMSRALADVMR	SHISA9	181	B4DS77
FLIKRRDMTRMFVHP	TANC2	751	Q9HCD6
MIEHVDYSGMRPLDR	TANC2	1191	Q9HCD6
MPARTVVFDSMRKHD	SKIV2L	671	Q15477
YPTRERASFNRMVMH	PLK4	826	O00444
IAEGIMPRHRFMSAY	SF3A2	141	Q15428
DRPFQRTVTMHKDSM	SDCBP2	186	Q9H190
DDAHFSMMVFRIGIP	SHANK1	66	Q9Y566
IHRMIEFVVREGPMF	U2SURP	431	O15042
TTLMRAMLDAHPEVR	TPST2	81	O60704
PMFVINEMRRIARHF	USP42	176	Q9H9J4
RRGSMVPFSMRILHA	TRAPPC12	471	Q8WVT3
MAEMIGEFPDLHRTI	TRABD	241	Q9H4I3
EDLMMASGRPRQRSH	WDHD1	361	O75717
FHRMMTGLRVELAPK	FAM20B	41	O75063
RETTMDFGMEPHSLF	SLAMF8	166	Q9P0V8
MATPMHRLIARRQAF	ZCCHC10	1	Q8TBK6
VTAGHMRFIMLHDIR	TRAPPC2	76	P0DI81
VTAGHMRFIMLHDIR	TRAPPC2B	76	P0DI82
SPERMMVADVFSHRF	USP11	536	P51784
SLDRHMRLHMGITPF	ZBTB34	386	Q8NCN2
TDFPAARERRMHVMP	LRIG2	641	O94898
ARERRMHVMPEDDVF	LRIG2	646	O94898
ISMMFESPFRRVMHA	NALCN	901	Q8IZF0