Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase I core binding	RRN3P2 RRN3	1.40e-05	4	31	2	GO:0001042
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	RRN3P2 RRN3	8.34e-05	9	31	2	GO:0001181
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIKFYVE PIP5K1C	8.34e-05	9	31	2	GO:0016308
GeneOntologyMolecularFunction	RNA polymerase I core promoter sequence-specific DNA binding	RRN3P2 RRN3	1.27e-04	11	31	2	GO:0001164
GeneOntologyMolecularFunction	RNA polymerase I transcription regulatory region sequence-specific DNA binding	RRN3P2 RRN3	1.80e-04	13	31	2	GO:0001163
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN10A KCNC1	3.13e-04	17	31	2	GO:0099508
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIKFYVE PIP5K1C	7.41e-04	26	31	2	GO:0052742
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	ERCC6L2 INO80	1.50e-03	37	31	2	GO:0140658
GeneOntologyMolecularFunction	lipid kinase activity	PIKFYVE PIP5K1C	1.84e-03	41	31	2	GO:0001727
GeneOntologyMolecularFunction	RNA polymerase core enzyme binding	RRN3P2 RRN3	2.22e-03	45	31	2	GO:0043175
GeneOntologyMolecularFunction	core promoter sequence-specific DNA binding	RRN3P2 RRN3	3.29e-03	55	31	2	GO:0001046
Domain	PIPK	PIKFYVE PIP5K1C	6.03e-05	8	28	2	PS51455
Domain	PIPKc	PIKFYVE PIP5K1C	6.03e-05	8	28	2	SM00330
Domain	-	PIKFYVE PIP5K1C	6.03e-05	8	28	2	3.30.800.10
Domain	PInositol-4-P-5-kinase_N	PIKFYVE PIP5K1C	6.03e-05	8	28	2	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIKFYVE PIP5K1C	6.03e-05	8	28	2	IPR027483
Domain	-	PIKFYVE PIP5K1C	6.03e-05	8	28	2	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIKFYVE PIP5K1C	6.03e-05	8	28	2	IPR002498
Domain	PIP5K	PIKFYVE PIP5K1C	6.03e-05	8	28	2	PF01504
Domain	SNF2_N	ERCC6L2 INO80	1.05e-03	32	28	2	PF00176
Domain	SNF2_N	ERCC6L2 INO80	1.05e-03	32	28	2	IPR000330
Domain	Znf_FYVE	PIKFYVE MLPH	1.47e-03	38	28	2	IPR000306
Domain	ZF_FYVE	PIKFYVE MLPH	1.63e-03	40	28	2	PS50178
Domain	Channel_four-helix_dom	SCN10A KCNC1	3.29e-03	57	28	2	IPR027359
Domain	-	SCN10A KCNC1	3.29e-03	57	28	2	1.20.120.350
Domain	Helicase_C	ERCC6L2 INO80	1.12e-02	107	28	2	PF00271
Domain	HELICc	ERCC6L2 INO80	1.12e-02	107	28	2	SM00490
Domain	Helicase_C	ERCC6L2 INO80	1.14e-02	108	28	2	IPR001650
Domain	HELICASE_CTER	ERCC6L2 INO80	1.16e-02	109	28	2	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC6L2 INO80	1.16e-02	109	28	2	PS51192
Domain	DEXDc	ERCC6L2 INO80	1.16e-02	109	28	2	SM00487
Domain	Helicase_ATP-bd	ERCC6L2 INO80	1.18e-02	110	28	2	IPR014001
Domain	Ion_trans_dom	SCN10A KCNC1	1.26e-02	114	28	2	IPR005821
Domain	Ion_trans	SCN10A KCNC1	1.26e-02	114	28	2	PF00520
Pubmed	Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.	RRN3P2 RRN3	8.20e-07	2	32	2	38745938
Pubmed	Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.	RRN3P2 RRN3	8.20e-07	2	32	2	12015311
Pubmed	DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.	RRN3P2 RRN3	8.20e-07	2	32	2	23393135
Pubmed	Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter.	RRN3P2 RRN3	8.20e-07	2	32	2	8413268
Pubmed	Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.	RRN3P2 RRN3	8.20e-07	2	32	2	30918302
Pubmed	Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.	RRN3P2 RRN3	8.20e-07	2	32	2	24273493
Pubmed	A neuroprotective phase precedes striatal degeneration upon nucleolar stress.	RRN3P2 RRN3	8.20e-07	2	32	2	23764776
Pubmed	Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.	RRN3P2 RRN3	8.20e-07	2	32	2	27257073
Pubmed	ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.	RRN3P2 RRN3	8.20e-07	2	32	2	12620228
Pubmed	Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.	RRN3P2 RRN3	8.20e-07	2	32	2	31110473
Pubmed	Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.	RRN3P2 RRN3	2.46e-06	3	32	2	34880223
Pubmed	TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.	RRN3P2 RRN3	2.46e-06	3	32	2	19217408
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PIKFYVE SETDB1 MIA3 RREB1 PACSIN2 ZNF687 TGS1	3.82e-06	733	32	7	34672954
Pubmed	Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.	RRN3P2 RRN3	4.92e-06	4	32	2	24297901
Pubmed	Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.	RRN3P2 RRN3	4.92e-06	4	32	2	28360124
Pubmed	Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.	RRN3P2 RRN3	8.19e-06	5	32	2	18559419
Pubmed	Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.	RRN3P2 RRN3	8.19e-06	5	32	2	19036968
Pubmed	The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.	RRN3P2 RRN3	8.19e-06	5	32	2	15805466
Pubmed	Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.	RRN3P2 RRN3	8.19e-06	5	32	2	21228155
Pubmed	Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.	PIKFYVE PIP5K1C	1.23e-05	6	32	2	20841379
Pubmed	Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.	PIKFYVE PIP5K1C	1.72e-05	7	32	2	15018809
Pubmed	A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription.	RRN3P2 RRN3	1.72e-05	7	32	2	28715449
Pubmed	Nuclear actin and myosin I are required for RNA polymerase I transcription.	RRN3P2 RRN3	1.72e-05	7	32	2	15558034
Pubmed	Btk-dependent regulation of phosphoinositide synthesis.	PIKFYVE PIP5K1C	2.29e-05	8	32	2	15046600
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE SPATA20 INO80 PIP5K1C CIT ZNF335 ZNF687	5.38e-05	1105	32	7	35748872
Pubmed	Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.	RRN3P2 RRN3	5.38e-05	12	32	2	15989966
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ETS2 SPRY1 DSPP	3.70e-04	152	32	3	34299191
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KIF13B CRYBG1 MIA3 INO80 PACSIN2 TGS1	4.09e-04	1084	32	6	11544199
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	KIF13B RAD51AP1 DSPP	5.22e-04	171	32	3	20201926
Pubmed	The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors.	KIF13B PACSIN2	8.28e-04	46	32	2	30659120
Pubmed	The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.	PIKFYVE PACSIN2	8.28e-04	46	32	2	23793062
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP	CRYBG1 INO80 RREB1 SDC1	5.13e-05	174	31	4	M1113
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP	CRYBG1 INO80 RREB1 SDC1	5.48e-05	177	31	4	MM479
Coexpression	GSE11386_NAIVE_VS_MEMORY_BCELL_UP	CRYBG1 RAD51AP1 CIT PACSIN2	6.51e-05	185	31	4	M374
Coexpression	GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_UP	GCNA ETS2 RRN3P2 RREB1	8.47e-05	198	31	4	M5850
Coexpression	GSE8515_CTRL_VS_IL1_4H_STIM_MAC_UP	KIF13B RREB1 RALBP1 PACSIN2	8.64e-05	199	31	4	M5759
Coexpression	GSE22886_IGG_IGA_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_UP	ETS2 PIKFYVE CRYBG1 SPRY1	8.64e-05	199	31	4	M4444
Coexpression	GSE13493_DP_VS_CD4INTCD8POS_THYMOCYTE_UP	ETS2 MIA3 SSH3 ZNF335	8.81e-05	200	31	4	M3312
Coexpression	MCBRYAN_PUBERTAL_BREAST_3_4WK_UP	ETS2 RAD51AP1 MLPH SDC1	1.14e-04	214	31	4	M13186
Coexpression	MCBRYAN_PUBERTAL_BREAST_3_4WK_UP	ETS2 RAD51AP1 MLPH SDC1	1.51e-04	230	31	4	MM986
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B CRYBG1 RALBP1 TGS1	1.10e-05	194	32	4	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B CRYBG1 RALBP1 TGS1	1.10e-05	194	32	4	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B CRYBG1 MLPH RALBP1	1.10e-05	194	32	4	4579b4a44f7c731553a284843c296866027d7c0e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B CRYBG1 MLPH RALBP1	1.12e-05	195	32	4	3d6d3de8ada6dce3dc789c15b50cc066e7100496
Drug	Midodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; HL60; HG-U133A	KIF13B THSD1 MLPH SDC1 SSH3	6.85e-06	199	31	5	1403_UP
Disease	polyunsaturated fatty acids to total fatty acids percentage	RRN3 ZNF335	1.35e-03	50	32	2	EFO_0022303
Disease	migraine disorder, type 2 diabetes mellitus	RREB1 CIT	1.94e-03	60	32	2	MONDO_0005148, MONDO_0005277
Disease	cholesterol to total lipids in medium VLDL percentage	RRN3 ZNF335	2.14e-03	63	32	2	EFO_0022239
Disease	triglycerides to total lipids in medium VLDL percentage	RRN3 ZNF335	2.14e-03	63	32	2	EFO_0022335
Disease	cholesteryl esters to total lipids in medium VLDL percentage	RRN3 ZNF335	2.20e-03	64	32	2	EFO_0022253
Disease	metabolite measurement, diet measurement	RRN3 ZNF335	2.70e-03	71	32	2	EFO_0004725, EFO_0008111
Disease	central corneal thickness	ETS2 MLPH SDC1	4.51e-03	309	32	3	EFO_0005213
Disease	Malignant mesothelioma	SETDB1 SDC1	6.24e-03	109	32	2	C0345967

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGDDPNSSDESNGND	DSPP	461	Q9NZW4
SDDDTSNFDEPEKNS	CIT	381	O14578
EGSDGDSANDTEPDF	RAD51AP1	186	Q96B01
AAFQEDSSGDEAESP	RALBP1	86	Q15311
PSADNSNLSADGDDS	INO80	1331	Q9ULG1
PRGDEDFQSDSDSFN	LRRC7	431	Q96NW7
AAQASPAQGDASEAD	PNMA6F	451	A0A0J9YX94
HDSPENGADSFESSD	ETS2	276	P15036
DESNNPFSSTDANGD	PACSIN2	401	Q9UNF0
DANGDSNPFDDDATS	PACSIN2	411	Q9UNF0
AEEGDDNLANSASPS	PIKFYVE	481	Q9Y2I7
SFGGAPLDNSADDAD	KCNC1	121	P48547
SDVPDDNSDDSSDDN	GCNA	186	Q96QF7
DDEVAPNAASDNASA	CRYBG1	41	Q9Y4K1
DGNTASDDESSDEQP	ERCC6L2	821	Q5T890
DFEGDSDDSTQPQGH	MLPH	196	Q9BV36
QDGSDAESDSDDPSY	PGBD3	66	Q8N328
DFSSQDNLDDPEAGG	KIF13B	1181	Q9NQT8
DSDDEDDNLPANFDT	RRN3	171	Q9NYV6
SQGSAAAEPEDDSFH	MIA3	891	Q5JRA6
ASDEEGAPASQASDE	PIP5K1C	616	O60331
PEDQDGSGDDSDNFS	SDC1	31	P18827
GNSGTEDPEESNDDS	SETDB1	891	Q15047
GGDNDDAAEASSEPT	SSH3	51	Q8TE77
GDADGAEEDASSNQS	RREB1	1346	Q92766
NSFSADNLTAPEDDG	SCN10A	891	Q9Y5Y9
DDQDGAEPSANSVSA	SPATA20	636	Q8TB22
PEDDASGSESFQSNA	THSD1	506	Q9NS62
HCSNDDEGDSYSDNP	SPRY1	231	O43609
DSDDEDDNLPANFDT	RRN3P2	171	A6NIE6
SSGAEAADEDSNDSP	ZNF687	306	Q8N1G0
DIDENPASDFDDSGS	TGS1	431	Q96RS0
SADSSDAAAAPGQAE	ZNF335	36	Q9H4Z2