Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnegative regulation of protein autophosphorylation

NLRP12 ADIPOQ

4.89e-0511202GO:0031953
Domainzf-CCCH

ZC3H6 TOE1

1.12e-0349192PF00642
DomainZnf_CCCH

ZC3H6 TOE1

1.57e-0358192IPR000571
DomainZF_C3H1

ZC3H6 TOE1

1.57e-0358192PS50103
DomainHomeodomain-like

TRERF1 GSC DLX3

4.37e-03332193IPR009057
DomainHomeobox_CS

GSC DLX3

1.51e-02186192IPR017970
DomainHomeobox

GSC DLX3

2.32e-02234192PF00046
DomainHOMEOBOX_1

GSC DLX3

2.36e-02236192PS00027
DomainHOX

GSC DLX3

2.38e-02237192SM00389
DomainHomeobox_dom

GSC DLX3

2.42e-02239192IPR001356
DomainHOMEOBOX_2

GSC DLX3

2.42e-02239192PS50071
Pubmed

Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.

ELSPBP1 RANBP17

9.42e-07320220503194
Pubmed

The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm.

GSC DLX3

1.88e-0642029226452
Pubmed

An endothelin-1 switch specifies maxillomandibular identity.

GSC DLX3

1.41e-051020219017795
Pubmed

Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch.

GSC DLX3

1.72e-051120222902530
Pubmed

The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.

GSC DLX3

1.72e-051120237341808
Pubmed

Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw.

GSC DLX3

1.72e-051120220333701
Pubmed

Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development.

GSC DLX3

2.07e-051220218199583
Pubmed

Sonic hedgehog is essential for first pharyngeal arch development.

GSC DLX3

2.44e-051320216492970
Pubmed

Tshz1 is required for axial skeleton, soft palate and middle ear development in mice.

GSC DLX3

2.44e-051320217586487
Pubmed

AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice.

NLRP12 ADIPOQ

3.28e-051520236873496
Pubmed

Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.

GSC DLX3

3.75e-051620224650709
Pubmed

MOZ directs the distal-less homeobox gene expression program during craniofacial development.

GSC DLX3

4.25e-051720231340933
Pubmed

Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.

GSC DLX3

4.25e-051720222411303
Pubmed

Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis.

GSC DLX3

4.78e-051820221558373
Pubmed

The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction.

GSC DLX3

5.93e-052020221237142
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TRERF1 CITED2 GSC ZC3H6 TOE1

7.75e-0580820520412781
Pubmed

Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis.

GSC DLX3

1.01e-042620233328221
Pubmed

Characterising the dynamics of placental glycogen stores in the mouse.

AGL DLX3

1.26e-042920232798765
Pubmed

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.

GSC CTAGE1

1.96e-043620233230114
Pubmed

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.

CITED2 DLX3

4.75e-045620230718289
CoexpressionGROSS_HYPOXIA_VIA_HIF1A_ONLY

CITED2 AGL

1.54e-058202M1292
CoexpressionGROSS_HYPOXIA_VIA_HIF1A_ONLY

CITED2 AGL

2.48e-0510202MM1122
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Rgs4_(Striatum,_interneuron)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SYCP2L DLX3 ADIPOQ

4.21e-0671203149504ce72da0730074ea436fc2034ce8cb585d5
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Rgs4_(Striatum,_interneuron)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SYCP2L DLX3 ADIPOQ

4.21e-0671203b0dbb059a7d05f825da608879b23aeebd6e9e61f
DrugCP-96,345

NLRP12 AASDHPPT AGL

1.48e-0555203CID000104943
Diseasenon-histone chromosomal protein HMG-14 measurement

NLRP12 ADIPOQ

2.31e-0512182EFO_0021872
DiseasePapillary Renal Cell Carcinoma

CSMD3 NLRP12 ADIPOQ

6.20e-05128183C1306837
DiseaseRenal Cell Carcinoma

CSMD3 NLRP12 ADIPOQ

6.20e-05128183C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

CSMD3 NLRP12 ADIPOQ

6.20e-05128183C1266043
DiseaseChromophobe Renal Cell Carcinoma

CSMD3 NLRP12 ADIPOQ

6.20e-05128183C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

CSMD3 NLRP12 ADIPOQ

6.20e-05128183C1266044
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

CSMD3 NLRP12 ADIPOQ

9.55e-05148183C0279702

Protein segments in the cluster

PeptideGeneStartEntry
PYPNFNFNISHQGDY

AASDHPPT

101

Q9NRN7
SQNKQGFHIVYQAYQ

CSMD3

2206

Q7Z407
GGNNFIQNFYLPQNY

CTAGE1

21

Q9HC47
RFTKIFYNQQNHYDG

ADIPOQ

131

Q15848
NPYTYHHQFNLNGLA

DLX3

61

O60479
QNAQNYQKLLHPYSG

RANBP17

466

Q9H2T7
QQVFVKCHFDYNPYN

PALS2

216

Q9NZW5
APHYFNYITNAVQQK

PIKFYVE

1891

Q9Y2I7
PCHFPFNYKNKNYFN

ELSPBP1

181

Q96BH3
NNYFYGQLHVQAAPV

GSC

81

P56915
QAYHQLFYQETLQPF

RGS22

701

Q8NE09
LQKLNNQYFNHHPYP

CITED2

116

Q99967
YYAQHSIHNFQPPNN

ZC3H6

601

P61129
IYTNQPTAQYHQQFN

RIBC1

361

Q8N443
YFQQKESHFPQKYNR

SYCP2L

46

Q5T4T6
VVNHFTPENKNYYFG

TCN1

166

P20061
FNFNQQYAQGIPYHK

TOE1

146

Q96GM8
QHQYYPPQQQQQAGQ

TRERF1

266

Q96PN7
NYNLAKGFNYHQGPE

AGL

1436

P35573
KYFHNAEQAGQVFNY

NLRP12

376

P59046