Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionadenylate cyclase regulator activity

RAF1 GRM7

1.54e-049422GO:0010854
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF5 PRAMEF26 PRAMEF6

2.10e-0455423GO:0042974
GeneOntologyMolecularFunctiontubulin binding

CCDC69 SPIRE1 DIAPH3 NF1 DCDC1 NLRP5

2.56e-04428426GO:0015631
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

ZNHIT6 CREBBP SMYD3

3.61e-0466423GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

ZNHIT6 CREBBP SMYD3

3.61e-0466423GO:0001098
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP10B ATP11B

3.87e-0414422GO:0140333
GeneOntologyMolecularFunctionmicrotubule binding

CCDC69 SPIRE1 DIAPH3 NF1 DCDC1

4.50e-04308425GO:0008017
GeneOntologyMolecularFunctionflippase activity

ATP10B ATP11B

5.76e-0417422GO:0140327
GeneOntologyMolecularFunctioncyclase regulator activity

RAF1 GRM7

6.47e-0418422GO:0010851
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF5 PRAMEF26 PRAMEF6

6.83e-0482423GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF5 PRAMEF26 PRAMEF6

1.05e-0395423GO:0140767
GeneOntologyMolecularFunctionMAP kinase kinase kinase activity

RAF1 ARAF

1.47e-0327422GO:0004709
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor binding

ZNHIT6 CREBBP

1.47e-0327422GO:0001091
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP10B ATP11B

1.58e-0328422GO:0140326
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

RAF1 CDC42BPG ARAF GRK4 MKNK1

2.34e-03446425GO:0004674
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF5 PRAMEF26 PRAMEF6

1.23e-0447433GO:0031462
GeneOntologyCellularComponentcleavage furrow

SPIRE1 PSD2 DIAPH3

2.68e-0461433GO:0032154
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP10B ATP11B

3.70e-0414432GO:1990531
GeneOntologyCellularComponentcell division site

SPIRE1 PSD2 DIAPH3

5.96e-0480433GO:0032153
DomainRBD

RAF1 ARAF

6.67e-056402PF02196
DomainRBD

RAF1 ARAF

9.33e-057402SM00455
DomainRBD_dom

RAF1 ARAF

9.33e-057402IPR003116
DomainRBD

RAF1 ARAF

9.33e-057402PS50898
DomainC1_1

RAF1 CDC42BPG ARAF

2.46e-0457403PF00130
DomainZF_DAG_PE_1

RAF1 CDC42BPG ARAF

3.46e-0464403PS00479
DomainZF_DAG_PE_2

RAF1 CDC42BPG ARAF

3.46e-0464403PS50081
DomainC1

RAF1 CDC42BPG ARAF

3.63e-0465403SM00109
DomainPE/DAG-bd

RAF1 CDC42BPG ARAF

3.79e-0466403IPR002219
DomainP_typ_ATPase_c

ATP10B ATP11B

4.00e-0414402IPR032630
DomainP-type_ATPase_N

ATP10B ATP11B

4.00e-0414402IPR032631
DomainP-type_ATPase_IV

ATP10B ATP11B

4.00e-0414402IPR006539
DomainPhoLip_ATPase_C

ATP10B ATP11B

4.00e-0414402PF16212
DomainPhoLip_ATPase_N

ATP10B ATP11B

4.00e-0414402PF16209
DomainPRAME_family

PRAMEF5 PRAMEF6

7.47e-0419402IPR026271
DomainDAG/PE-bd

RAF1 ARAF

9.15e-0421402IPR020454
DomainSer/Thr_kinase_AS

RAF1 CDC42BPG ARAF GRK4 MKNK1

9.42e-04357405IPR008271
DomainS_TKc

RAF1 CDC42BPG ARAF GRK4 MKNK1

9.66e-04359405SM00220
DomainPROTEIN_KINASE_ST

RAF1 CDC42BPG ARAF GRK4 MKNK1

1.00e-03362405PS00108
DomainDAPIN

NLRP2 NLRP5

1.01e-0322402PS50824
DomainDAPIN

NLRP2 NLRP5

1.01e-0322402IPR004020
DomainPYRIN

NLRP2 NLRP5

1.01e-0322402SM01289
DomainPYRIN

NLRP2 NLRP5

1.01e-0322402PF02758
DomainNACHT

NLRP2 NLRP5

1.10e-0323402PS50837
DomainNACHT_NTPase

NLRP2 NLRP5

1.10e-0323402IPR007111
DomainProtein_kinase_ATP_BS

RAF1 CDC42BPG ARAF GRK4 MKNK1

1.23e-03379405IPR017441
DomainPkinase

RAF1 CDC42BPG ARAF GRK4 MKNK1

1.26e-03381405PF00069
Domain-

ATP10B ATP11B

2.13e-03324022.70.150.10
Domain-

ATP10B ATP11B

2.13e-03324023.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP10B ATP11B

2.54e-0335402IPR023299
DomainATPase_P-typ_P_site

ATP10B ATP11B

2.69e-0336402IPR018303
DomainP_typ_ATPase

ATP10B ATP11B

2.69e-0336402IPR001757
DomainATPASE_E1_E2

ATP10B ATP11B

2.69e-0336402PS00154
DomainPROTEIN_KINASE_ATP

RAF1 CDC42BPG ARAF GRK4 MKNK1

2.84e-03459405PS00107
DomainATPase_P-typ_transduc_dom_A

ATP10B ATP11B

2.84e-0337402IPR008250
DomainE1-E2_ATPase

ATP10B ATP11B

2.84e-0337402PF00122
DomainProt_kinase_dom

RAF1 CDC42BPG ARAF GRK4 MKNK1

3.73e-03489405IPR000719
DomainPROTEIN_KINASE_DOM

RAF1 CDC42BPG ARAF GRK4 MKNK1

3.86e-03493405PS50011
Domain-

PRAMEF5 NLRP2 PRAMEF6 NLRP5

4.81e-033214043.80.10.10
DomainL_dom-like

PRAMEF5 NLRP2 PRAMEF6 NLRP5

5.19e-03328404IPR032675
DomainKinase-like_dom

RAF1 CDC42BPG ARAF GRK4 MKNK1

5.75e-03542405IPR011009
DomainQuinoprotein_ADH-like_supfam

OLFM1 NWD1

5.75e-0353402IPR011047
DomainLRR_6

NLRP2 NLRP5

6.18e-0355402PF13516
DomainAGC-kinase_C

CDC42BPG GRK4

6.40e-0356402IPR000961
DomainAGC_KINASE_CTER

CDC42BPG GRK4

6.40e-0356402PS51285
DomainS_TK_X

CDC42BPG GRK4

6.40e-0356402SM00133
Domain-

ATP10B ATP11B

8.29e-03644023.40.50.1000
PathwayWP_PILOCYTIC_ASTROCYTOMA

RAF1 NF1

4.15e-056242M39584
PathwayWP_FRAGILE_X_SYNDROME

RAF1 NF1 ARAF MKNK1

4.80e-05121244M39804
PathwayREACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS

RAF1 ARAF

7.73e-058242M38999
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE

RAF1 ARAF

7.73e-058242M47933
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.24e-0410242M47374
PathwayKEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.24e-0410242M47420
PathwayKEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.24e-0410242M47735
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.51e-0411242M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.51e-0411242M47371
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.81e-0412242M47369
PathwayKEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.81e-0412242M47597
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.81e-0412242M47815
PathwayWP_MELANOMA

RAF1 NF1 ARAF

2.02e-0468243M39811
PathwayREACTOME_ION_CHANNEL_TRANSPORT

RAF1 ATP10B ATP11B TTYH2

2.05e-04176244MM15718
PathwayKEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.14e-0413242M47589
PathwayKEGG_LONG_TERM_POTENTIATION

RAF1 CREBBP ARAF

2.20e-0470243M3115
PathwayKEGG_RENAL_CELL_CARCINOMA

RAF1 CREBBP ARAF

2.20e-0470243M13266
PathwayREACTOME_ION_CHANNEL_TRANSPORT

RAF1 ATP10B ATP11B TTYH2

2.38e-04183244M997
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.50e-0414242M47488
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.50e-0414242M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.50e-0414242M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.50e-0414242M47366
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.50e-0414242M47378
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.50e-0414242M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.50e-0414242M47384
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47367
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47474
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47495
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47375
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47497
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47382
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47592
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47472
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47640
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.88e-0415242M47531
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.29e-0416242M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.29e-0416242M47373
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.29e-0416242M47483
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.29e-0416242M47381
PathwayKEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY

RAF1 ARAF

3.29e-0416242M47682
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.29e-0416242M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.29e-0416242M47801
PathwayREACTOME_ONCOGENIC_MAPK_SIGNALING

RAF1 NF1 ARAF

3.52e-0482243M27626
PathwayWP_GLIOBLASTOMA_SIGNALING

RAF1 NF1 ARAF

3.64e-0483243M39637
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.72e-0417242M47376
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY

RAF1 ARAF

3.72e-0417242M47684
PathwayWP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE

RAF1 NF1 ARAF

3.77e-0484243M39839
PathwayWP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS

RAF1 ARAF

4.18e-0418242M39737
PathwayKEGG_PROSTATE_CANCER

RAF1 CREBBP ARAF

4.47e-0489243M13191
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

RAF1 ARAF

4.67e-0419242M47596
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

4.67e-0419242M47793
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

5.72e-0421242M47792
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

RAF1 CREBBP

5.72e-0421242M27485
PathwayKEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

6.88e-0423242M47799
PathwayWP_MAPK_SIGNALING

RAF1 NF1 ARAF MKNK1

7.30e-04246244M39597
PathwayWP_4HYDROXYTAMOXIFEN_DEXAMETHASONE_AND_RETINOIC_ACIDS_REGULATION_OF_P27_EXPRESSION

RAF1 MKNK1

8.14e-0425242M39574
PathwayWP_NOVEL_JUNDMP1_PATHWAY

RAF1 ARAF

8.14e-0425242MM15984
PathwayBIOCARTA_ERK_PATHWAY

RAF1 MKNK1

9.50e-0427242M287
PathwayWP_MAPK_CASCADE

RAF1 ARAF

1.02e-0328242MM15976
PathwayBIOCARTA_ERK_PATHWAY

RAF1 MKNK1

1.02e-0328242MM1391
PathwayWP_MAPK_CASCADE

RAF1 ARAF

1.42e-0333242M39594
PathwayREACTOME_RAF_ACTIVATION

RAF1 ARAF

1.51e-0334242M27556
PathwayKEGG_INSULIN_SIGNALING_PATHWAY

RAF1 ARAF MKNK1

1.57e-03137243M18155
PathwayREACTOME_RAF_ACTIVATION

RAF1 ARAF

1.60e-0335242MM15271
PathwayKEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.60e-0335242M47379
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

RAF1 ARAF

1.98e-0339242MM15272
PathwayWP_HEPATITIS_B_INFECTION

RAF1 CREBBP ARAF

2.07e-03151243M39801
PathwayWP_BLADDER_CANCER

RAF1 ARAF

2.08e-0340242M39523
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

RAF1 ARAF

2.08e-0340242M27557
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

RAF1 ARAF

2.19e-0341242M39655
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

RAF1 ARAF

2.29e-0342242MM15274
PathwayKEGG_BLADDER_CANCER

RAF1 ARAF

2.29e-0342242M19096
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

RAF1 ARAF

2.40e-0343242M27560
PathwayREACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS

RAF1 ARAF

2.63e-0345242M27623
PathwayWP_NOTCH_SIGNALING_WP268

CREBBP DTX3

2.63e-0345242M39571
PathwayWP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2586

RAF1 NF1

2.75e-0346242M39661
PathwayWP_NOTCH_SIGNALING_PATHWAY

CREBBP DTX3

2.75e-0346242MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

CREBBP DTX3

2.87e-0347242M7946
PathwayBIOCARTA_NFAT_PATHWAY

RAF1 CREBBP

3.11e-0349242MM1442
PathwayWP_MIRNA_REGULATION_OF_PROSTATE_CANCER_SIGNALING

RAF1 CREBBP

3.11e-0349242M39683
PathwayBIOCARTA_NFAT_PATHWAY

RAF1 CREBBP

3.37e-0351242M2288
PathwayPID_KIT_PATHWAY

RAF1 CREBBP

3.50e-0352242M231
PathwayKEGG_ENDOMETRIAL_CANCER

RAF1 ARAF

3.50e-0352242M19877
PathwayWP_TGFBETA_SIGNALING_PATHWAY

INHBA CREBBP

3.63e-0353242MM15880
PathwayKEGG_NON_SMALL_CELL_LUNG_CANCER

RAF1 ARAF

3.77e-0354242M19818
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

INHBA CREBBP

3.90e-0355242M39351
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP10B ATP11B

3.90e-0355242M971
PathwayKEGG_ACUTE_MYELOID_LEUKEMIA

RAF1 ARAF

4.19e-0357242M19888
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP10B ATP11B

4.19e-0357242MM15643
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

INHBA CREBBP

4.48e-0359242M39886
PathwayWP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA

RAF1 ARAF

4.48e-0359242M39750
PathwayKEGG_COLORECTAL_CANCER

RAF1 ARAF

4.94e-0362242M14631
PathwayWP_ENDOMETRIAL_CANCER

RAF1 ARAF

5.09e-0363242M39623
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF5 PRAMEF26 NLRP2 PRAMEF6 NLRP5

2.77e-102845525089626
Pubmed

Mammalian Ras interacts directly with the serine/threonine kinase Raf.

RAF1 ARAF

1.64e-0624528334704
Pubmed

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.

NF1 ARAF

1.64e-06245235613620
Pubmed

Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest.

NLRP2 NLRP5

1.64e-06245230877238
Pubmed

A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.

RAF1 ARAF

1.64e-06245227240957
Pubmed

A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.

RAF1 ARAF

1.64e-06245215856007
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF5 PRAMEF26 PRAMEF6

3.06e-062245331729367
Pubmed

The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.

RAF1 NF1 ARAF TTYH2

3.60e-068045428205554
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF5 PRAMEF26 PRAMEF6

4.56e-062545337451217
Pubmed

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

RAF1 ARAF

4.91e-06345220130576
Pubmed

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.

RAF1 ARAF

4.91e-06345210704835
Pubmed

Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles.

RAF1 NF1

4.91e-0634528628317
Pubmed

Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.

RAF1 ARAF

4.91e-06345214688025
Pubmed

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.

RAF1 ARAF

4.91e-06345222926515
Pubmed

Expression of raf family proto-oncogenes in normal mouse tissues.

RAF1 ARAF

4.91e-0634521690378
Pubmed

Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.

RAF1 ARAF

4.91e-06345220052757
Pubmed

Endothelial apoptosis in Braf-deficient mice.

RAF1 ARAF

4.91e-0634529207797
Pubmed

Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.

RAF1 ARAF

4.91e-06345223352452
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF5 NLRP2 PRAMEF6

8.02e-063045338786026
Pubmed

Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.

RAF1 ARAF

9.81e-0644528394352
Pubmed

Identification of interaction between MEK2 and A-Raf-1.

RAF1 ARAF

9.81e-06445211909642
Pubmed

Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.

RAF1 ARAF

9.81e-0644528621729
Pubmed

RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A.

RAF1 NF1

9.81e-06445218592002
Pubmed

Aberrant expression of COT is related to recurrence of papillary thyroid cancer.

RAF1 ARAF

9.81e-06445225674762
Pubmed

Functional characterization of a PROTAC directed against BRAF mutant V600E.

RAF1 ARAF

9.81e-06445232778845
Pubmed

Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1.

RAF1 NF1

9.81e-06445234184824
Pubmed

B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.

RAF1 ARAF

9.81e-0644527731720
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF5 PRAMEF26 PRAMEF6

1.29e-053545319389355
Pubmed

In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice.

RAF1 ARAF

1.63e-05545217219248
Pubmed

Germline gain-of-function mutations in RAF1 cause Noonan syndrome.

RAF1 ARAF

1.63e-05545217603482
Pubmed

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

RAF1 ARAF

1.63e-05545224746704
Pubmed

Isoform-specific localization of A-RAF in mitochondria.

RAF1 ARAF

2.45e-05645210848612
Pubmed

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

RAF1 ARAF

2.45e-0564528157000
Pubmed

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.

HELZ SMYD3

3.42e-05745215235609
Pubmed

Structural, expression, and evolutionary analysis of mouse CIAS1.

NLRP2 NLRP5

3.42e-05745215302403
Pubmed

Identification of Nore1 as a potential Ras effector.

RAF1 ARAF

3.42e-0574529488663
Pubmed

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.

RAF1 ARAF

5.86e-05945219667065
Pubmed

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

RAF1 ARAF

5.86e-05945230595535
Pubmed

A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes.

RAF1 ARAF

5.86e-05945217967876
Pubmed

Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.

RAF1 ARAF

5.86e-05945211969417
Pubmed

Essential role of B-Raf in ERK activation during extraembryonic development.

RAF1 ARAF

7.32e-051045216432225
Pubmed

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro.

RAF1 NF1

8.94e-051145211435472
Pubmed

p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons.

RAF1 NF1

8.94e-05114529852579
Pubmed

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.

ATP10B ATP11B

1.07e-041245221914794
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP10B ATP11B

1.27e-041345211015572
Pubmed

Cardiac deletion of Smyd2 is dispensable for mouse heart development.

HELZ SMYD3

1.27e-041345220305823
Pubmed

The genetics of NOD-like receptors in Crohn's disease.

NLRP2 NLRP5

1.47e-041445220403135
Pubmed

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

RAF1 ARAF

1.47e-041445231015455
Pubmed

Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.

RAF1 ARAF

1.47e-041445228073913
Pubmed

NALPs: a novel protein family involved in inflammation.

NLRP2 NLRP5

1.47e-041445212563287
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF5 PRAMEF6

2.20e-041745223565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF5 PRAMEF6

2.20e-041745237781892
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF5 PRAMEF6

2.47e-041845229731491
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF5 PRAMEF6

2.47e-041845223894331
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF5 PRAMEF6

2.47e-041845214675769
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF5 PRAMEF6

2.47e-041845212890732
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF5 PRAMEF6

2.47e-041845239181896
Pubmed

Genes, plasticity and mental retardation.

NF1 CREBBP

2.76e-041945218329113
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF5 PRAMEF6

2.76e-041945228604677
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF5 PRAMEF6

3.06e-042045226694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF5 PRAMEF6

3.06e-042045216580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF5 PRAMEF6

3.06e-042045221425410
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

RAF1 SPIRE1 ARAF

3.18e-0410245315778465
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

HELZ NF1 ARAF

3.36e-0410445331240132
Pubmed

Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.

RAF1 ARAF

4.07e-042345212620389
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF5 PRAMEF6

4.07e-042345219480014
Pubmed

Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.

NDP NF1

4.82e-04254528889551
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF5 PRAMEF6

4.82e-042545212620990
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

CDC42BPG NF1 CREBBP ARAF

4.92e-0428345421903422
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF5 PRAMEF6

5.22e-042645218500982
Pubmed

Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.

CREBBP ARAF

5.22e-042645217177285
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

RAF1 HELZ ZFHX3 ZNHIT6 DCDC1 CREBBP ARAF

5.37e-04111645731753913
Pubmed

Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.

RAF1 ARAF

6.96e-043045234017080
Pubmed

Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.

RAF1 ARAF

7.43e-04314528034307
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF5 PRAMEF6

7.92e-043245237889087
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

RAF1 HELZ SPIRE1 NF1 RFX7 ARAF

8.09e-0486145636931259
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

PRAMEF5 NLRP2 PRAMEF6 NLRP5

8.34e-0432645417015433
Pubmed

Tagging genes with cassette-exchange sites.

CDC42BPG HELZ RFX7 CREBBP

9.23e-0433545415741177
Pubmed

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

RAF1 ARAF

1.00e-033645235379950
Pubmed

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

DCDC1 HECTD4

1.06e-033745222797727
Pubmed

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

RAF1 ARAF

1.12e-033845219608861
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

RAF1 ARAF SMYD3 DNAH17

1.24e-0336345425036637
InteractionEEF1AKMT3 interactions

RAF1 CDC42BPG HELZ ZNHIT6 NLRP2 ARAF SMYD3

7.84e-06364417int:EEF1AKMT3
InteractionTRMT61A interactions

RAF1 CDC42BPG HELZ GRK4

3.62e-0592414int:TRMT61A
InteractionWRAP53 interactions

RAF1 HELZ ZFHX3 NF1

3.94e-0594414int:WRAP53
Cytoband1p36.21

PRAMEF5 PRAMEF26 PRAMEF6

3.58e-05634631p36.21
GeneFamilyPRAME family

PRAMEF5 PRAMEF26 PRAMEF6

9.94e-0624323686
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 ARAF

3.02e-0553221157
GeneFamilyATPase phospholipid transporting

ATP10B ATP11B

3.14e-04153221210
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 ARAF

8.17e-0424322654
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP2 NLRP5

8.88e-0425322994
GeneFamilyNLR family

NLRP2 NLRP5

8.88e-0425322666
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE1 DIAPH3 ERI2 GRK4

1.98e-051554649b26ade19488511c72b64335011d2dcd81e8f167
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE1 DIAPH3 ERI2 GRK4

1.98e-05155464cd2f3ad4f131588325a667b6724e530d821fbe30
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE1 DIAPH3 ERI2 GRK4

1.98e-051554644246709e27703b94529369abbed5763e4002e79d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OLFM1 ATP10B INHBA TTYH2

3.11e-051744649c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OLFM1 ATP10B INHBA TTYH2

3.11e-05174464bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
DiseaseRetinal Neovascularization

NDP NF1

5.65e-063412C0035320
DiseaseRASopathy

RAF1 NF1

1.96e-0415412cv:C5555857
Diseasecortisol measurement

INHBA MKNK1

3.52e-0420412EFO_0005843
Diseaserenal system measurement, blood urea nitrogen measurement

DCDC1 HECTD4

4.28e-0422412EFO_0004741, EFO_0004742
DiseaseNoonan Syndrome

RAF1 NF1

5.10e-0424412C0028326
Diseasemean arterial pressure

ZFHX3 NDP DCDC1 GRM7 HECTD4

6.15e-04499415EFO_0006340
Diseasecarbohydrate intake measurement

ZFHX3 HECTD4

1.03e-0334412EFO_0010811
DiseaseCutaneous Melanoma

RAF1 NF1

1.49e-0341412C0151779
Diseasehigh grade glioma (implicated_via_orthology)

RAF1 ARAF

1.72e-0344412DOID:3070 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

PSD2 CREBBP GRK4

2.52e-03195413DOID:1574 (implicated_via_orthology)
DiseaseAntithrombotic agent use measurement

ZFHX3 HECTD4

2.67e-0355412EFO_0009925

Protein segments in the cluster

PeptideGeneStartEntry
KMTPPLCKCGRRSKR

ERI2

591

A8K979
PCFLRRKMPCLLKVA

ERC2-IT1

6

O76042
PSLMQLCRLRIRKCF

ASB9

256

Q96DX5
RCMADKTLPECSKLP

AFM

76

P43652
RNANCSLPSCQKMKR

CREBBP

1786

Q92793
MRCGLKEILPNLKCI

DIAPH3

366

Q9NSV4
LCCRSTPLQKSMIVK

ATP10B

1026

O94823
MGCRHSRLSSCKPPK

CCDC69

1

A6NI79
NLKSCCVPTKLRPMS

INHBA

386

P08476
MQRGKPCRALPTLKC

NWD1

1

Q149M9
CLMKALKVRGLQPEC

RAF1

81

P04049
KCLRCTSLMLGLGRQ

CDC42BPG

891

Q6DT37
LSPDGKRKTMLCLAC

DCDC1

1311

M0R2J8
ERLRACMQKLACGKL

OLFM1

216

Q99784
LSKRCAPRCPNDNMK

LY6L

71

H3BQJ8
GMKFLCEALRKPLCN

NLRP2

941

Q9NX02
RAMKTLCAKLRHPTC

NLRP5

796

P59047
ANTSCGLPLKMLRKT

HECTD4

116

Q9Y4D8
RAVLCCMQLKGKLQP

HELZ

96

P42694
SCRLCSFRKMRSPPK

MTERF2

11

Q49AM1
RALQVKKACPMCGRF

DTX3

191

Q8N9I9
LSKISSNCPKAMRRL

ARAF

531

P10398
SNCPKAMRRLLSDCL

ARAF

536

P10398
IVLKTLPCLVRMCSK

ARMC8

276

Q8IUR7
KTALQKLCMVRCLRP

DNAH17

3821

Q9UFH2
CQMSELRLLLLGKCR

GIMAP8

6

Q8ND71
NHPVGCKRKLAMSRC

ZNHIT6

206

Q9NWK9
AKRCCLQPRDAAKMP

CERS1

86

P27544
LLMGGCRNKCLSVLK

MAB21L2

241

Q9Y586
GLLKCRCRMLFNDLK

MARCHF4

36

Q9P2E8
KLLRVLTLMKFPCCV

GRM7

6

Q14831
CRMLLTKNPSKRLGC

GRK4

421

P32298
LCCKKLKILGMPFRN

PRAMEF26

86

H0Y7S4
LCSMKLSPPCKSRLA

MKNK1

431

Q9BUB5
RCLLGKEKLMRCSQC

SMYD3

51

Q9H7B4
LCCRMAPLQKAKVIR

ATP11B

791

Q9Y2G3
CCKKLKILGMPFRNI

PRAMEF6

181

Q5VXH4
VSSMKKFCRPLLPSC

PSD2

636

Q9BQI7
CLGLAKRSKCLLASM

TTYH2

231

Q9BSA4
RPVCSQCCKKMRLPS

SPIRE1

616

Q08AE8
CCKKLKILGMPFRNI

PRAMEF5

181

Q5TYX0
IGRMCKIIDKTCLSP

NF1

2051

P21359
QRTKCKSRCNEMLPG

RFX7

501

Q2KHR2
PLYKCSSKMVLLARC

NDP

51

Q00604
KLLQTRCKGRRMCPK

ZNF516-DT

91

Q6ZTR6
RCKGRRMCPKAGDQT

ZNF516-DT

96

Q6ZTR6
AIVMCITRKCPKNNR

TMEFF1

346

Q8IYR6
GKRKPILMCFLCKLS

ZFHX3

276

Q15911