Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmanganese ion binding

ADCY10 B4GALT7

5.51e-0471102GO:0030145
GeneOntologyMolecularFunctiontransition metal ion binding

ADCY10 B4GALT7 IDE CPO

1.97e-031189104GO:0046914
GeneOntologyMolecularFunctionmetallopeptidase activity

IDE CPO

4.26e-03200102GO:0008237
GeneOntologyMolecularFunctionhexosyltransferase activity

B4GALT7 ALG8

4.73e-03211102GO:0016758
GeneOntologyMolecularFunctionglycosyltransferase activity

B4GALT7 ALG8

8.64e-03288102GO:0016757
GeneOntologyCellularComponentpeptidase complex

TRRAP IDE

1.75e-03133102GO:1905368
MousePhenoabnormal parietal yolk sac morphology

COL4A1 SMCHD1 TRRAP

1.07e-0417783MP:0011203
MousePhenoabnormal trophoblast layer morphology

SMCHD1 TRRAP BIRC6

1.80e-0421183MP:0005031
MousePhenointracerebral hemorrhage

COL4A1 BIRC6

2.68e-044482MP:0001916
MousePhenoincreased circulating creatine kinase level

COL4A1 BIRC6

5.16e-046182MP:0010090
MousePhenoincreased creatine kinase level

COL4A1 BIRC6

5.33e-046282MP:0020280
MousePhenoabnormal circulating creatine kinase level

COL4A1 BIRC6

5.85e-046582MP:0010089
MousePhenoabnormal creatine kinase level

COL4A1 BIRC6

6.04e-046682MP:0020279
MousePhenoabnormal extraembryonic tissue morphology

COL4A1 SMCHD1 TRRAP BIRC6

1.00e-0390884MP:0002086
MousePhenointracranial hemorrhage

COL4A1 BIRC6

1.49e-0310482MP:0001915
MousePhenoabnormal trophoblast giant cell morphology

SMCHD1 TRRAP

1.55e-0310682MP:0005033
MousePhenoabnormal mural trophectoderm morphology

SMCHD1 TRRAP

1.58e-0310782MP:0012057
Domain-

ADCY10 TRRAP

5.19e-032071021.25.40.10
DomainTPR-like_helical_dom

ADCY10 TRRAP

6.53e-03233102IPR011990
Pubmed

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.

SMCHD1 B4GALT7 BIRC6

1.24e-0435910335559673
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

SMCHD1 TRRAP BIRC6

2.72e-0446910327634302
InteractionDACT2 interactions

SMCHD1 TRRAP

2.12e-051692int:DACT2
InteractionSPINK14 interactions

IDE BIRC6

2.12e-051692int:SPINK14
InteractionPPRC1 interactions

TRRAP BIRC6

3.71e-052192int:PPRC1
InteractionTINAG interactions

COL4A1 IDE

6.66e-052892int:TINAG
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

SMCHD1 IDE BIRC6

8.17e-0618610303db813598b67b1e08f759758a1c2023396921fa
ToppCellMS-CD4-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

ADCY10 SMCHD1

5.01e-04152102b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|367C / Donor, Lineage, Cell class and subclass (all cells)

SMCHD1 DUSP10

5.35e-04157102f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCellPND01-03-samps|World / Age Group, Lineage, Cell class and subclass

COL4A1 BIRC6

5.62e-041611021973b112d8d67aacc02751797d0148e7b53bfa66
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 DUSP10

5.69e-04162102735fa3f77b31a4189e431d05c326403c18cbbffb
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 DUSP10

5.69e-0416210268c40d12689cc1b6c797e6e48173f0110f8144e4
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--|Striatum / BrainAtlas - Mouse McCarroll V32

BIRC6 ALG8

6.19e-041691025375eb52ebadccb7bfff997a11985f23e81014d6
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)|Striatum / BrainAtlas - Mouse McCarroll V32

BIRC6 ALG8

6.19e-04169102c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-|Striatum / BrainAtlas - Mouse McCarroll V32

BIRC6 ALG8

6.19e-041691021c132d21255f5a5174ac38db4e91927f9093418e
ToppCellSevere-B_activate-7|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

COL4A1 DUSP10

6.33e-0417110261205a4986c2d0a89aea96ed8dec9e952eeb6ff1
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B4GALT7 BIRC6

6.33e-04171102c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCellfacs|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B4GALT7 BIRC6

6.41e-04172102a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCelldroplet-Fat-Mat-18m-Lymphocytic-lymphocyte|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMCHD1 DUSP10

6.41e-04172102226de1a5d4a360d3ae01b0235fea19521ec623a0
ToppCellfacs|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B4GALT7 BIRC6

6.63e-0417510253e96956019f984decc1c81376ebc88fbf3c4d40
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A1 DUSP10

6.71e-041761024843af68f013732c28a8b8edad30d5fa0f2b084b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A1 DUSP10

6.78e-04177102c20df760b25caa772278397b02fc36521927cbfc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 DUSP10

6.86e-04178102a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A1 DUSP10

6.94e-041791023b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A1 DUSP10

7.09e-04181102153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMCHD1 DUSP10

7.09e-04181102d66838fca0429cad2079cd8d92a5cd33eb0d3522
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A1 DUSP10

7.25e-041831025a541a7f6c3514be8a13e988185dfe388c874f8b
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SMCHD1 DUSP10

7.33e-041841028b397f9c18ed7abecdbcbd586d0ddadf07cf6e75
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SMCHD1 DUSP10

7.33e-04184102300edc4aa3ce55f309005c02c315fa0102ea9da7
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMCHD1 BIRC6

7.33e-041841021154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A1 DUSP10

7.33e-04184102c4c1a3d279ca733b865ce46570d7642dc137f9a4
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

SMCHD1 BIRC6

7.41e-04185102a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-Treg|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SMCHD1 DUSP10

7.41e-04185102a86a3a1a187a4d8d7762bc6d3dcb22c982178d22
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

SMCHD1 BIRC6

7.48e-041861028571956890fc9894d766ba294a28e376b4aba428
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

SMCHD1 BIRC6

7.65e-04188102ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell368C-Lymphocytic-B_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

SMCHD1 DUSP10

7.81e-04190102b9abf773525f7bbc87b8c0d4e94e9d18017de82b
ToppCell368C-Lymphocytic-B_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

SMCHD1 DUSP10

7.81e-041901021a016ae2603be5d024ba024faafd725787db8c48
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

SMCHD1 BIRC6

7.89e-041911029454f642c3621370fa23640b631301346b300950
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL4A1 ADCY10

7.97e-04192102fee99ca7e658963acf968aa724ef8c96cfc00a5d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMCHD1 DUSP10

8.05e-04193102bbea475d2c4c7b29674ff302529f8f83dd666dcb
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

SMCHD1 DUSP10

8.05e-041931027256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|367C / Donor, Lineage, Cell class and subclass (all cells)

SMCHD1 DUSP10

8.05e-041931028f8d2006fb40a207c743cfd2e9a9f47c2bac1eea
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

SMCHD1 DUSP10

8.05e-041931022ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCellControl-Treg|Control / Disease condition and Cell class

SMCHD1 DUSP10

8.22e-04195102bbe9789eb2c17f43de55b2e6d01d1093c64dc666
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A1 DUSP10

8.30e-04196102acbb493dbb49a33f20cf11106363f7ed51209706
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SMCHD1 DUSP10

8.30e-0419610285684b881655e47f06f0cf00721183825fa00913
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SMCHD1 DUSP10

8.30e-04196102e38036a5dbaed1488e01616bdc7678b28968470b
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A1 DUSP10

8.47e-04198102b258f672529fb2c03e62e2696d335043c4963280
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A1 DUSP10

8.47e-041981020993d6895c0e4f360998ce35abea4ec3dd13e048
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A1 DUSP10

8.47e-041981025e70246a9ce199cb2fb5379912b8ab59456219e4
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-04200102b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-04200102bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Myeloid|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DUSP10 TRRAP

8.64e-04200102cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-0420010279e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-04200102a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DUSP10 TRRAP

8.64e-042001020d76b006d8e8b32174e65e400acd0674354b962c
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMCHD1 BIRC6

8.64e-0420010212f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL4A1 BIRC6

8.64e-04200102dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-0420010266f7e8ee63c828f17468e79a4b816346b33e8980
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-0420010289821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellLPS_IL1RA_TNF-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-04200102d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-04200102be55cef682ba87250dad97689332c8820b3a7420
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-04200102432384faeade8e609154fab3d96c955a8ec868dd
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma|TCGA-Liver / Sample_Type by Project: Shred V9

B4GALT7 ALG8

8.64e-04200102bc7aba2885ca1093fcd884807b497700dae4835e
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

COL4A1 SMCHD1

8.64e-04200102edb64556b3fefe3144f73b6efe23b9ffd34091d2
ComputationalNeighborhood of MSH2

TRRAP ALG8

4.68e-046162MORF_MSH2
DiseaseGlobal developmental delay

COL4A1 TRRAP

8.86e-04133102C0557874
DiseaseSeizures

COL4A1 TRRAP

2.35e-03218102C0036572

Protein segments in the cluster

PeptideGeneStartEntry
AKIPLGFYYGHTYIL

BIRC6

1871

Q9NR09
LDYSLYHHLAGYKGV

ADCY10

1256

Q96PN6
HSYGQLILTPYGYTK

CPO

236

Q8IVL8
PSGTKILYHGYSLLY

COL4A1

1461

P02462
HPLYHYKTYVGGILL

B4GALT7

191

Q9UBV7
THLPLYHYEKGLFNY

DUSP10

356

Q9Y6W6
RGYTSKIAGILHYYP

IDE

431

P14735
LAHIYHYYIHGPKGN

SMCHD1

346

A6NHR9
LHFKHIYLYVAPAYG

ALG8

196

Q9BVK2
LYIRGHNGKIYPYLV

TRRAP

3516

Q9Y4A5