Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	dendrite	GABRB1 OPN4 PRSS12 L1CAM SHANK3 GSK3B PRR7 SORT1 RIN1 AKAP9 P2RY1 TNN LRP2 TNK2 PREX1 CNGA3 HSPB1	3.45e-04	858	161	17	GO:0030425
GeneOntologyCellularComponent	dendritic tree	GABRB1 OPN4 PRSS12 L1CAM SHANK3 GSK3B PRR7 SORT1 RIN1 AKAP9 P2RY1 TNN LRP2 TNK2 PREX1 CNGA3 HSPB1	3.54e-04	860	161	17	GO:0097447
GeneOntologyCellularComponent	lysosome	TNFAIP8L2 SPHK2 ABCA3 SLC38A9 GDAP2 RNF19B LARS1 RPS6KC1 SORT1 TINAGL1 USP5 NEU2 AP5M1 LRP2 HCK HYAL2	5.42e-04	811	161	16	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	TNFAIP8L2 SPHK2 ABCA3 SLC38A9 GDAP2 RNF19B LARS1 RPS6KC1 SORT1 TINAGL1 USP5 NEU2 AP5M1 LRP2 HCK HYAL2	5.42e-04	811	161	16	GO:0000323
GeneOntologyCellularComponent	growth cone	L1CAM CBL GSK3B NEFL LRP2 TNK2 PREX1 CNR1	6.40e-04	245	161	8	GO:0030426
GeneOntologyCellularComponent	vacuole	TNFAIP8L2 SPHK2 ABCA3 SLC38A9 GDAP2 RNF19B LARS1 RPS6KC1 SORT1 TINAGL1 USP5 NEU2 AP5M1 LRP2 C4BPA HCK HYAL2	6.96e-04	913	161	17	GO:0005773
GeneOntologyCellularComponent	site of polarized growth	L1CAM CBL GSK3B NEFL LRP2 TNK2 PREX1 CNR1	7.89e-04	253	161	8	GO:0030427
MousePheno	lethality, incomplete penetrance	TNFAIP8L2 B3GNT5 CHD2 SHANK3 NAGS LFNG ALKBH1 AKAP9 CLMP HYAL2 CNR1 RAI1	4.31e-06	258	128	12	MP:0010831
Domain	TMEM183	TMEM183A TMEM183BP	7.20e-05	2	159	2	IPR026509
Domain	HECW_N	HECW1 HECW2	7.20e-05	2	159	2	IPR032348
Domain	GTPase_binding	ERRFI1 TNK2	7.20e-05	2	159	2	PF09027
Domain	Inhibitor_Mig-6	ERRFI1 TNK2	7.20e-05	2	159	2	PF11555
Domain	HECW_N	HECW1 HECW2	7.20e-05	2	159	2	PF16562
Domain	Mig-6	ERRFI1 TNK2	7.20e-05	2	159	2	IPR021619
Domain	Cdc42_binding_dom-like	ERRFI1 TNK2	7.20e-05	2	159	2	IPR015116
Domain	TIL_dom	TECTA LRP2 MUC5AC	2.06e-04	14	159	3	IPR002919
Domain	DUF1736	TMTC2 TMTC1	4.27e-04	4	159	2	IPR013618
Domain	Heparan_SO4_deacetylase	NDST1 NDST4	4.27e-04	4	159	2	IPR021930
Domain	HSNSD	NDST1 NDST4	4.27e-04	4	159	2	PF12062
Domain	DUF1736	TMTC2 TMTC1	4.27e-04	4	159	2	PF08409
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	SPHK2 HECW1 MED14 GSK3B HECW2 RAD54B KMT2A GMPPA RAI1 MPG	7.92e-07	281	160	10	24163370
Pubmed	APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.	KLK3 CBL JAK2	1.89e-06	6	160	3	10374881
Pubmed	Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.	SORT1 PEMT LPL ERRFI1 RAI1	2.82e-06	48	160	5	24262325
Pubmed	Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.	CBL CLYBL HCK	5.26e-06	8	160	3	20304029
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF845 RADX CHD2 GPATCH8 HP1BP3 ZNF12 NOP58 RBAK RAD54B KMT2A DOT1L RAI1 MPG	5.28e-06	608	160	13	36089195
Pubmed	Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.	LFNG ZFPM2 NEFL	7.87e-06	9	160	3	10225993
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	CBL ERRFI1 TNK2 SOS2	1.59e-05	33	160	4	18271526
Pubmed	Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo.	ETV6 JAK2	2.10e-05	2	160	2	17077140
Pubmed	DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β.	GSK3B JAK2	2.10e-05	2	160	2	22087308
Pubmed	Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia.	KMT2A DOT1L	2.10e-05	2	160	2	38892207
Pubmed	Synapse structure: glutamate receptors connected by the shanks.	DLGAP1 SHANK3	2.10e-05	2	160	2	10574750
Pubmed	MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.	KMT2A DOT1L	2.10e-05	2	160	2	21741597
Pubmed	DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy.	KMT2A DOT1L	2.10e-05	2	160	2	24858818
Pubmed	Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line.	CBL HCK	2.10e-05	2	160	2	12032836
Pubmed	The role of DOT1L in the maintenance of leukemia gene expression.	KMT2A DOT1L	2.10e-05	2	160	2	27151433
Pubmed	Linkage between polymorphisms in the prostate specific antigen ARE1 gene region, prostate cancer risk, and circulating tumor cells.	KLK3 VPS52	2.10e-05	2	160	2	12210484
Pubmed	Anti-inflammatory effects of MerTK by inducing M2 macrophage polarization via PI3K/Akt/GSK-3β pathway in gout.	GSK3B MERTK	2.10e-05	2	160	2	39217874
Pubmed	Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.	CBL JAK2	2.10e-05	2	160	2	28676638
Pubmed	Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.	GSK3B KMT2A	2.10e-05	2	160	2	18806775
Pubmed	Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro.	LPL LRP2	2.10e-05	2	160	2	7686151
Pubmed	Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.	TMEM183A TMEM183BP	2.10e-05	2	160	2	16644869
Pubmed	CBL mutations in infant acute lymphoblastic leukaemia.	CBL KMT2A	2.10e-05	2	160	2	21988239
Pubmed	REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway.	GSK3B PSME3	2.10e-05	2	160	2	25908095
Pubmed	Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.	PLIN2 CNR1	2.10e-05	2	160	2	31570772
Pubmed	Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia.	CBL KMT2A	2.10e-05	2	160	2	12696071
Pubmed	Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice.	GSK3B PSME3	2.10e-05	2	160	2	26370326
Pubmed	Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein.	ETV6 NCOR1	2.10e-05	2	160	2	11001911
Pubmed	Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg).	TG LRP2	2.10e-05	2	160	2	9492085
Pubmed	Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia.	PLIN2 ERRFI1	2.10e-05	2	160	2	12387890
Pubmed	The molecular mechanics of mixed lineage leukemia.	KMT2A DOT1L	2.10e-05	2	160	2	26923329
Pubmed	Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1.	NEFL HSPB1	2.10e-05	2	160	2	17881652
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ARHGAP23 CHD2 GPATCH8 CBL GSK3B JAK2 AKAP9 ERRFI1 KMT2A AK2 TNK2 PSME3 MERTK HCK CNN1	2.18e-05	910	160	15	36736316
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	SHB CBL GSK3B RIN1 TNK2	2.58e-05	75	160	5	15951569
Pubmed	Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.	HECW1 CBL TNK2	4.17e-05	15	160	3	19144635
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FOXJ2 FNDC3B ZNF845 L1CAM CHD2 TMEM214 GPATCH8 CBL HP1BP3 ZNF12 NOP58 VPS52 RBAK LPGAT1 SARAF HSPB1 SLC27A4	4.27e-05	1203	160	17	29180619
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FNDC3B ARHGAP23 LARS1 TOR4A CHD2 HNRNPUL1 GSK3B ZGPAT RIN1 ALKBH1 USP5 NOP58 UTP15 PSME3 HSPB1 PHLDB2 SLC27A4 MPG	5.49e-05	1353	160	18	29467282
Pubmed	Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.	OPN4 CNGA3	6.29e-05	3	160	2	12808468
Pubmed	TIPE2 functions as a metastasis suppressor via negatively regulating β-catenin through activating GSK3β in gastric cancer.	TNFAIP8L2 GSK3B	6.29e-05	3	160	2	26530498
Pubmed	Gsk3β regulates the resolution of liver ischemia/reperfusion injury via MerTK.	GSK3B MERTK	6.29e-05	3	160	2	36422999
Pubmed	Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.	KMT2A DOT1L	6.29e-05	3	160	2	28394257
Pubmed	Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.	KMT2A DOT1L	6.29e-05	3	160	2	26118503
Pubmed	Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.	CBL HCK	6.29e-05	3	160	2	11896602
Pubmed	Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation.	OPN4 CNGA3	6.29e-05	3	160	2	19060203
Pubmed	A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration.	OPN4 CNGA3	6.29e-05	3	160	2	29625451
Pubmed	Sortilin is a putative postendocytic receptor of thyroglobulin.	TG SORT1	6.29e-05	3	160	2	18687776
Pubmed	Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.	SORT1 LPL	6.29e-05	3	160	2	10085125
Pubmed	The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).	ETV6 L3MBTL1	6.29e-05	3	160	2	12588862
Pubmed	Photoreceptor regulation of spatial visual behavior.	OPN4 CNGA3	6.29e-05	3	160	2	25670495
Pubmed	Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.	KMT2A DOT1L	6.29e-05	3	160	2	23361907
Pubmed	Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.	KMT2A DOT1L	6.29e-05	3	160	2	21398221
Pubmed	The optokinetic reflex as a tool for quantitative analyses of nervous system function in mice: application to genetic and drug-induced variation.	OPN4 CNGA3	6.29e-05	3	160	2	18446207
Pubmed	Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice.	NDST1 LPL	6.29e-05	3	160	2	18845532
Pubmed	CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.	CBL JAK2	6.29e-05	3	160	2	28611190
Pubmed	Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3β signaling in gastric cancer.	GKN2 GSK3B	6.29e-05	3	160	2	27323966
Pubmed	Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.	JAK2 PREX1	6.29e-05	3	160	2	23478800
Pubmed	Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells.	OPN4 CNGA3	6.29e-05	3	160	2	24559673
Pubmed	A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.	KMT2A DOT1L	6.29e-05	3	160	2	31527241
Pubmed	Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.	CBL HCK	6.29e-05	3	160	2	12652654
Pubmed	Chronic IL9 and IL-13 exposure leads to an altered differentiation of ciliated cells in a well-differentiated paediatric bronchial epithelial cell model.	MMP7 MUC5AC	6.29e-05	3	160	2	23671562
Pubmed	Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.	CBL ERRFI1 SOS2	7.41e-05	18	160	3	19531499
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HECW1 ARHGAP23 DIS3L RNF213 SHANK3 FAN1 ALMS1 TRPM3 LPGAT1 PREX1	1.02e-04	493	160	10	15368895
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RADX RNF213 ARFGEF3 VPS52 PHLDB2	1.23e-04	104	160	5	31240132
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST1 NDST4	1.25e-04	4	160	2	22049073
Pubmed	Analysis of gene rearrangements using a fluorescence in situ hybridization method in Mexican patients with acute lymphoblastic leukemia: experience at a single institution.	ETV6 KMT2A	1.25e-04	4	160	2	18617057
Pubmed	CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling.	GSK3B CNR1	1.25e-04	4	160	2	20083607
Pubmed	The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells.	ETV6 JAK2	1.25e-04	4	160	2	11314018
Pubmed	The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries.	NDST1 LPL	1.25e-04	4	160	2	24726386
Pubmed	M-cadherin distribution in the mouse adult neuromuscular system suggests a role in muscle innervation.	L1CAM NEFL	1.25e-04	4	160	2	8921257
Pubmed	FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4-GSK3β-Nrf2 Signaling.	GSK3B FGF19	1.25e-04	4	160	2	28951455
Pubmed	Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites.	TMTC2 TMTC1	1.25e-04	4	160	2	33436046
Pubmed	Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase.	CBL HCK	1.25e-04	4	160	2	8995358
Pubmed	NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells.	OPN4 CNGA3	1.25e-04	4	160	2	28959188
Pubmed	The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.	CBL HCK	1.25e-04	4	160	2	10092522
Pubmed	Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.	OPN4 TRPM3	1.25e-04	4	160	2	22211741
Pubmed	Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways.	OPN4 CNGA3	1.25e-04	4	160	2	27301998
Pubmed	MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.	KMT2A DOT1L	1.25e-04	4	160	2	26927674
Pubmed	Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision.	OPN4 CNGA3	1.25e-04	4	160	2	20624591
Pubmed	Cannabinoid receptor 1 regulates ERK and GSK-3β-dependent glucocorticoid inhibition of osteoblast differentiation in murine MC3T3-E1 cells.	GSK3B CNR1	1.25e-04	4	160	2	21914493
Pubmed	Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A mutations in patients with Leber congenital amaurosis.	ALMS1 CNGA3	1.25e-04	4	160	2	21901789
Pubmed	Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations.	CBL ERRFI1	1.25e-04	4	160	2	24445374
Pubmed	Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.	ERRFI1 TNK2	1.25e-04	4	160	2	36178070
Pubmed	TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3.	ETV6 NCOR1	1.25e-04	4	160	2	11439334
Pubmed	Expression of GluA2-containing calcium-impermeable AMPA receptors on dopaminergic amacrine cells in the mouse retina.	OPN4 CNGA3	1.25e-04	4	160	2	31819340
Pubmed	CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.	CBL JAK2	1.25e-04	4	160	2	23696637
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST1 NDST4	1.25e-04	4	160	2	12070138
Pubmed	DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.	KMT2A DOT1L	1.25e-04	4	160	2	21521783
Pubmed	Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception.	OPN4 CNGA3	1.25e-04	4	160	2	21124784
Pubmed	Intrinsically photosensitive retinal ganglion cells detect light with a vitamin A-based photopigment, melanopsin.	OPN4 CNGA3	1.25e-04	4	160	2	16014418
Pubmed	Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.	JAK2 HCK	1.25e-04	4	160	2	17183644
Pubmed	Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities.	OPN4 CNGA3	1.25e-04	4	160	2	20711184
Pubmed	Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis Through the Akt/GSK-3β/β-catenin/Bcl-2 Pathway.	RNF213 GSK3B	1.25e-04	4	160	2	37778692
Pubmed	Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins.	TMTC2 TMTC1	1.25e-04	4	160	2	28973932
Pubmed	Regulation of prokineticin 2 expression by light and the circadian clock.	OPN4 CNGA3	1.25e-04	4	160	2	15762991
Pubmed	RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.	CBL HCK	1.25e-04	4	160	2	11239464
Pubmed	HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.	JAK2 HSPB1	1.25e-04	4	160	2	29650953
Pubmed	A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.	INPP5E GSK3B	1.25e-04	4	160	2	28650469
Pubmed	TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide repeat-containing adapter proteins involved in calcium homeostasis.	TMTC2 TMTC1	1.25e-04	4	160	2	24764305
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NDST1 L1CAM RNF213 TMTC2 MANEA TMEM214 CACHD1 CDKAL1 SORT1 IGSF10 USP5 LPL LPGAT1 AK2 SARAF MPG	1.43e-04	1201	160	16	35696571
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DLGAP1 MED14 EXTL1 F2RL2 SHANK3 JAK2 LRP2 SOS2	1.51e-04	329	160	8	17474147
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CUL2 HECW1 GSK3B ADAMTS12 MTMR6 TRPM3 HECW2 LRP2 KMT2A PSME3 MMP7 HCK	1.53e-04	730	160	12	34857952
ToppCell	Control-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	ROBO4 ARHGAP23 SHANK3 ZFPM2 TMTC1 HECW2 HYAL2 PHLDB2	5.11e-07	192	161	8	f95fb188aa642f3d0618242a770e7c4b70544adb
ToppCell	Control-Endothelial-Lymphatic\|Control / Disease state, Lineage and Cell class	ROBO4 ARHGAP23 SHANK3 ZFPM2 TMTC1 HECW2 HYAL2 PHLDB2	5.31e-07	193	161	8	64d19be73e5432d491436a01da5de5c926b615a9
ToppCell	Control-Endothelial\|Control / Disease state, Lineage and Cell class	ROBO4 ARHGAP23 SHANK3 ZFPM2 TINAGL1 TMTC1 HECW2 HYAL2	5.53e-07	194	161	8	485fe5538fabec457b9a51feb641f2a91cbf4e18
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA3 GKN2 ARFGEF3 PARD6B ERRFI1 LRP2 C4BPA CNR1	6.95e-07	200	161	8	b535323e18d9fb0dde1e0026df142c831e48c29f
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	F2RL2 TG SLC35A3 GAB3 TNK2 ADAMTS14 PREX1	1.94e-06	160	161	7	6b0faaa371650563f585722f5b2fb319e124ec38
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ABCA3 GKN2 ARFGEF3 PARD6B LRP2 C4BPA CNR1	2.29e-06	164	161	7	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	ABCA3 GKN2 ARFGEF3 PARD6B LRP2 C4BPA CNR1	2.29e-06	164	161	7	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 ARFGEF3 FAM13A ERRFI1 CLMP C4BPA MMP7	4.90e-06	184	161	7	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP23 TECTA P2RY1 LPL MERTK RAB3IL1 HCK	5.07e-06	185	161	7	7bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ARHGAP23 SHANK3 ZFPM2 TINAGL1 RIN1 PHLDB2	5.26e-06	186	161	7	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLGAP1 ABCA3 PARD6B FAM13A TRPM3 ERRFI1 PHLDB2	5.26e-06	186	161	7	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ARHGAP23 SHANK3 ZFPM2 TINAGL1 RIN1 PHLDB2	5.26e-06	186	161	7	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ILDR2 ROBO4 SHANK3 ART1 HECW2 PREX1 HYAL2	5.44e-06	187	161	7	97b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCell	Control-Endothelial_cells-Endothelial_cells_(general)\|Control / group, cell type (main and fine annotations)	ROBO4 PTCHD4 SHANK3 TMTC1 HECW2 PREX1 HYAL2	5.44e-06	187	161	7	fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ROBO4 F2RL2 SHANK3 LFNG TINAGL1 ARFGEF3 GAB3	5.44e-06	187	161	7	03de3c2df31bca0dc4e3718bada708d8fe8b69b9
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ROBO4 SHANK3 ZFPM2 TMTC1 HECW2 HYAL2 PHLDB2	5.64e-06	188	161	7	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ILDR2 ROBO4 SHANK3 ART1 HECW2 SARAF PREX1	6.47e-06	192	161	7	7197e401e563441ab94815f7619e032ebef9e586
ToppCell	COPD-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	ROBO4 ARHGAP23 SHANK3 ZFPM2 HECW2 HYAL2 PHLDB2	6.69e-06	193	161	7	25bdc557055b5bce6a21f8696b48e991c696b979
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO4 CACHD1 SHANK3 TMCC3 ZFPM2 HECW2 MERTK	6.69e-06	193	161	7	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	IPF-Endothelial\|IPF / Disease state, Lineage and Cell class	ROBO4 ARHGAP23 SHANK3 TINAGL1 TMTC1 HECW2 HYAL2	6.92e-06	194	161	7	9591993aa2dcba3d09a0f1ea8b8f2439c26482d6
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 PRSS12 TMTC2 TMCC3 TINAGL1 HYAL2 PHLDB2	7.16e-06	195	161	7	52b2bbf12e5f86c493f6634697aeb23a68cc916d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ARHGAP23 SHANK3 TMTC1 HECW2 PREX1 HYAL2	7.40e-06	196	161	7	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ARHGAP23 SHANK3 TMTC1 HECW2 PREX1 HYAL2	7.40e-06	196	161	7	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 CACHD1 SHANK3 TMTC1 HECW2 PREX1 HYAL2	7.40e-06	196	161	7	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ARHGAP23 SHANK3 TMTC1 HECW2 PREX1 HYAL2	7.40e-06	196	161	7	d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCell	LPS_IL1RA_TNF\|World / Treatment groups by lineage, cell group, cell type	ADAMTS12 IGSF10 AKAP9 FAM13A LPL ERRFI1 MMP7	7.65e-06	197	161	7	0a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCell	medial-2-Epithelial-Alveolar_Epithelial_Type_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ABCA3 GKN2 CACHD1 ARFGEF3 PARD6B LRP2 C4BPA	7.91e-06	198	161	7	102a4cbb138adbfba11ed955420095daa098532f
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_2-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ABCA3 GKN2 CACHD1 ARFGEF3 PARD6B LRP2 C4BPA	7.91e-06	198	161	7	7caeed2d5dc78866023c8f38edcec9886baa9f2c
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ABCA3 GKN2 CACHD1 ARFGEF3 PARD6B LRP2 C4BPA	7.91e-06	198	161	7	53e5d76831d70b9a476f3ef3a81e13eda974d543
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	DLGAP1 PRSS12 AKAP9 FAM13A KMT2A CLMP CNR1	7.91e-06	198	161	7	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Biopsy_Other_PF-Epithelial-AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ABCA3 GKN2 ARFGEF3 PARD6B LRP2 C4BPA CNR1	8.17e-06	199	161	7	9a65acfe9bf500db72142469cf17bf0973540001
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA3 GKN2 ARFGEF3 PARD6B LRP2 C4BPA CNR1	8.17e-06	199	161	7	a38a981cffa61c8444a980916de7414e689a1b63
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar-AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA3 GKN2 ARFGEF3 PARD6B ERRFI1 LRP2 C4BPA	8.45e-06	200	161	7	23088edc62bf7d4db890937bfd7925dc316fcc76
ToppCell	Tuft-tuft-3\|World / Class top	NDST1 PMEL VPS52 P2RY1 RBAK RAB3IL1	1.66e-05	148	161	6	f4f59b46a79fc9aa4c5d330a7b37b1a34a6d71cc
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	INPP5E SORT1 P2RY1 LPL HYAL2 SOS2	1.72e-05	149	161	6	c773c2b9685ec44a35246180a93456c8765353f5
ToppCell	metastatic_Brain-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	USP45 NAGS C9orf43 CNN1 HSPB1 PRIMPOL	2.07e-05	154	161	6	423f58fc7dcef068458cbf7b4ee989e37227041e
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF19B LFNG SYCN SLC35A3 CRYBG3 MERTK	2.31e-05	157	161	6	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	OPN4 ARHGAP23 SHANK3 TMTC1 HECW2 PREX1	2.48e-05	159	161	6	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PRSS12 EXTL1 SORT1 RIN1 NEFL ADRA1D	2.66e-05	161	161	6	ba7ce599b173cf81c8323e7c96dc3d57379f1ed6
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRB1 EXTL1 SORT1 RIN1 NEFL ADRA1D	3.38e-05	168	161	6	6db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP23 TMTC1 ART1 RAD54B ADAMTS14 TBX20	3.50e-05	169	161	6	7c994653b0d629dfb046755d6b678452de0a15d2
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 NEB SHANK3 TMCC3 TINAGL1 HSPB1	3.99e-05	173	161	6	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ARHGAP23 SHANK3 LFNG TMTC1 HECW2	3.99e-05	173	161	6	3877cead288ce9509e6cccf57e55ec5e1bd7ce18
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OPN4 ZFPM2 TMTC1 RAD54B CRYBG3 CNGA3	4.53e-05	177	161	6	96d639407f79669f3990138793d157b94273581c
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLGAP1 PARD6B TRPM3 MYO3B ERRFI1 PHLDB2	4.53e-05	177	161	6	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	Control-Epithelial_alveolar-AT_1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLGAP1 PARD6B TRPM3 MYO3B ERRFI1 PHLDB2	4.67e-05	178	161	6	aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCell	Control-Epithelial_alveolar-AT_1-AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLGAP1 PARD6B TRPM3 MYO3B ERRFI1 PHLDB2	4.67e-05	178	161	6	1817bc520f3d23da8c0fa09bba50ae703a820cb1
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 ARFGEF3 FAM13A ERRFI1 C4BPA MMP7	4.82e-05	179	161	6	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC25A42 HECW1 PLIN2 TRPM3 ERRFI1 LRP2	4.82e-05	179	161	6	78fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 SHB CACHD1 SHANK3 HECW2 PREX1	4.82e-05	179	161	6	8f9e538c822940785130297712b75131812a4603
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Endothelial\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TREX1 L1CAM SHANK3 TINAGL1 TMTC1 HSPB1	4.97e-05	180	161	6	f9b7d5eb7b6ea72253c89bdc351ad2b4a53f7d8e
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EXTL1 F2RL2 ADAMTS12 TNN CLMP ADAMTS14	4.97e-05	180	161	6	935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell	5'-Airway_Nasal-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EXTL1 F2RL2 ADAMTS12 TNN CLMP ADAMTS14	4.97e-05	180	161	6	3dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHB TMTC2 ERRFI1 LRP2 RBM24 CNN1	4.97e-05	180	161	6	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Endothelial-endothelial_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TREX1 L1CAM SHANK3 TINAGL1 TMTC1 HSPB1	4.97e-05	180	161	6	53db6032eda0e590ae7e01c9c3b472785ea6782f
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	DLGAP1 ABCA3 CACHD1 ARFGEF3 LRP2 C4BPA	4.97e-05	180	161	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Endothelial-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TREX1 L1CAM SHANK3 TINAGL1 TMTC1 HSPB1	4.97e-05	180	161	6	28bc10b9d0e4430b952260014d8a6ff337860ac6
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHB TMTC2 ERRFI1 LRP2 RBM24 CNN1	4.97e-05	180	161	6	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ARHGAP23 TMTC2 TINAGL1 JAK2 PHLDB2	5.13e-05	181	161	6	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	Control-Epithelial_alveolar-AT_1-AT1-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B TRPM3 MYO3B ERRFI1 CLMP MMP7	5.29e-05	182	161	6	a95956ce4adccb34cc0c47ebfa1878ce4617904e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ILDR2 ROBO4 SHANK3 ZFPM2 ART1 HECW2	5.29e-05	182	161	6	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	wk_15-18-Epithelial-PNS-SST+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HECW1 L1CAM GPR139 NEFL TBX20 CNR1	5.29e-05	182	161	6	a7e77aaaddabf78c7784f72b3431703fc5ee4a8c
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ARHGAP23 SHANK3 ZFPM2 TINAGL1 IGSF10	5.29e-05	182	161	6	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 PLIN2 FAM13A ERRFI1 C4BPA MMP7	5.29e-05	182	161	6	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ABCA3 CACHD1 ARFGEF3 PARD6B LRP2 C4BPA	5.45e-05	183	161	6	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EXTL1 F2RL2 ADAMTS12 TNN CLMP ADAMTS14	5.45e-05	183	161	6	803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PMEL ADAMTS12 RIN1 RAD54B DOT1L RAI1	5.45e-05	183	161	6	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EXTL1 F2RL2 ADAMTS12 TNN CLMP ADAMTS14	5.45e-05	183	161	6	6d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EXTL1 F2RL2 ADAMTS12 TNN CLMP ADAMTS14	5.45e-05	183	161	6	cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 PARD6B TRPM3 ERRFI1 MMP7 PHLDB2	5.45e-05	183	161	6	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 ARFGEF3 PARD6B ERRFI1 C4BPA MMP7	5.45e-05	183	161	6	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	DLGAP1 ABCA3 CACHD1 ARFGEF3 LRP2 C4BPA	5.62e-05	184	161	6	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	COPD-Endothelial-VE_Venous\|COPD / Disease state, Lineage and Cell class	ROBO4 SHANK3 SYCN TINAGL1 TMTC1 HYAL2	5.62e-05	184	161	6	44d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD2 NEB F2RL2 GAB3 RBM24 PREX1	5.62e-05	184	161	6	2c8e9ddce3e60302965dcf9dee77c4fe33e4071d
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 TRPM3 ERRFI1 CLMP C4BPA MMP7	5.79e-05	185	161	6	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDST4 TMTC2 PTCHD4 TMCC3 TMTC1 CLMP	5.79e-05	185	161	6	ae53aa2ecfe418a5dbd7d963a995bc06dab94f56
ToppCell	IPF-Epithelial-ATII\|IPF / Disease state, Lineage and Cell class	ABCA3 GKN2 ARFGEF3 PARD6B LRP2 C4BPA	5.79e-05	185	161	6	563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 PARD6B FAM13A ERRFI1 C4BPA MMP7	5.79e-05	185	161	6	fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCell	Control-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	ROBO4 SHANK3 ZFPM2 TINAGL1 HECW2 HYAL2	5.79e-05	185	161	6	a28187c2fd23564314b35759479ff2ca21f61485
ToppCell	IPF-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ABCA3 GKN2 ARFGEF3 PARD6B LRP2 C4BPA	5.96e-05	186	161	6	6a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCell	343B-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ROBO4 NDST1 P2RY1 HECW2 PREX1 HYAL2	5.96e-05	186	161	6	dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	ROBO4 SHANK3 TMTC1 HECW2 PREX1 HYAL2	5.96e-05	186	161	6	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	343B-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ROBO4 NDST1 P2RY1 HECW2 PREX1 HYAL2	5.96e-05	186	161	6	080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 PARD6B TRPM3 ERRFI1 C4BPA MMP7	6.14e-05	187	161	6	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	Control-Endothelial-VE_Capillary_A\|Control / Disease state, Lineage and Cell class	ROBO4 SHANK3 ZFPM2 TINAGL1 HECW2 HYAL2	6.14e-05	187	161	6	54d7588172ac145ff5045ad9771636729ca3f0ca
ToppCell	Endothelial-A-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 ARHGAP23 TINAGL1 TMTC1 ADRA1D HYAL2	6.14e-05	187	161	6	febe0b99a6a815ce687160a0e7af55228b1d5beb
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	ROBO4 ARHGAP23 SHANK3 ZFPM2 TMTC1 HECW2	6.14e-05	187	161	6	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	Endothelial-endothelial_cell_of_lymph_vessel\|World / Lineage, Cell type, age group and donor	ROBO4 SHANK3 ZFPM2 TMTC1 HECW2 HYAL2	6.33e-05	188	161	6	80910dcbb51990f2baed240f319456c0d3fa2065
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	CACHD1 SHANK3 ZFPM2 TMTC1 HECW2 HYAL2	6.33e-05	188	161	6	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	COPD-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	CBL SORT1 TINAGL1 PARD6B CNN1 HSPB1	6.33e-05	188	161	6	9ffef4b01d0ddd6913c9ed6be79aeaaabd5e41ed
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	ABCA3 GKN2 CACHD1 ARFGEF3 PARD6B C4BPA	6.33e-05	188	161	6	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	Control-Endothelial_cells\|Control / group, cell type (main and fine annotations)	ROBO4 SHANK3 TMTC1 HECW2 PREX1 HYAL2	6.33e-05	188	161	6	3953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCell	Endothelial-A-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 SHANK3 TINAGL1 TMTC1 HECW2 HYAL2	6.33e-05	188	161	6	0824d567356d360fd8e78e840c30529c139f98a1
ToppCell	Control-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	ARHGAP23 SHANK3 ZFPM2 TINAGL1 TMTC1 HYAL2	6.52e-05	189	161	6	f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCell	IPF-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	ROBO4 PTCHD4 SHANK3 TINAGL1 HECW2 HYAL2	6.52e-05	189	161	6	ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 SHANK3 ZFPM2 TINAGL1 RIN1 PHLDB2	6.52e-05	189	161	6	ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK3 TMCC3 SORT1 P2RY1 HECW2 MERTK	6.52e-05	189	161	6	e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	JAK2 LPL GAB3 RBM24 CNN1 PHLDB2	6.52e-05	189	161	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	ABCA3 GKN2 CACHD1 ARFGEF3 PARD6B C4BPA	6.71e-05	190	161	6	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACHD1 SHANK3 TMTC1 HECW2 HSPB1 HYAL2	6.71e-05	190	161	6	1caeaef78326734c1e31a0c4739190d5c5a77b9e
Drug	Tranexamic acid [1197-18-8]; Up 200; 25.4uM; MCF7; HT_HG-U133A	TOR4A TG PARD6B ADRA1D TRPM3 C4BPA MERTK MUC5AC CNN1 SOS2	1.38e-06	197	160	10	2248_UP
Drug	Sulconazole nitrate [61318-91-0]; Down 200; 8.6uM; MCF7; HT_HG-U133A	NDST1 SPHK2 MED14 ETV6 CDKAL1 JAK2 ALMS1 ZNF611 SOS2	8.28e-06	190	160	9	3373_DN
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; MCF7; HT_HG-U133A	CDKAL1 PARD6B ADRA1D ALMS1 JMJD6 KMT2A TNK2 MERTK SOS2	1.02e-05	195	160	9	4345_DN
Drug	Sulfadoxine [2447-57-6]; Up 200; 12.8uM; PC3; HT_HG-U133A	PRSS12 USP5 LPL RAD54B LRP2 TNK2 MERTK CNN1 SOS2	1.06e-05	196	160	9	5852_UP
Drug	estradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A	NDST1 SPHK2 SHB NEB ZNF442 PARD6B JAK2 MTMR6 KMT2A	1.06e-05	196	160	9	1666_UP
Drug	Rifampicin [13292-46-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A	ETV6 PMEL CBL CDKAL1 PARD6B RIN1 ALMS1 AK2 SOS2	1.06e-05	196	160	9	2847_UP
Disease	myeloid neoplasm (is_implicated_in)	ETV6 CBL JAK2	5.19e-06	7	158	3	DOID:0070004 (is_implicated_in)
Disease	Child Development Disorders, Specific	DOCK8 CBL SHANK3 LRP2	1.69e-05	29	158	4	C0085997
Disease	Child Development Deviations	DOCK8 CBL SHANK3 LRP2	1.69e-05	29	158	4	C0085996
Disease	Developmental Disabilities	DOCK8 CBL SHANK3 LRP2	1.95e-05	30	158	4	C0008073
Disease	Hematologic Neoplasms	ETV6 CBL JAK2	3.20e-05	12	158	3	C0376545
Disease	neutrophil count	FOXJ2 ILDR2 NDST1 SPHK2 ARHGAP23 DOCK8 INPP5E GDAP2 ZNF491 GSK3B CDKAL1 ZFPM2 JAK2 ZNF12 ZGPAT JMJD6 CLMP PREX1 FGF19	1.58e-04	1382	158	19	EFO_0004833
Disease	myeloproliferative neoplasm (implicated_via_orthology)	CBL JAK2	1.70e-04	4	158	2	DOID:2226 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NDST1 ABCA3 NDST4 CHD2 SHANK3 PREX1	1.75e-04	152	158	6	DOID:0060041 (implicated_via_orthology)
Disease	disposition index measurement	TMCC3 CDKAL1	2.82e-04	5	158	2	EFO_0006832
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	ETV6 JAK2 KMT2A HCK	3.26e-04	61	158	4	C1961102
Disease	age at menarche	FNDC3B DLGAP1 ETFDH NDST4 CHD2 GPR139 CDKAL1 RPS6KC1 ALMS1 CLYBL TRPM3	3.76e-04	594	158	11	EFO_0004703
Disease	Eye Diseases, Hereditary	INPP5E LRP2	4.21e-04	6	158	2	C0015398
Disease	trefoil factor 1 measurement	GKN2 MUC5AC	4.21e-04	6	158	2	EFO_0021865
Disease	gamma-enolase measurement	ZFPM2 USP5	4.21e-04	6	158	2	EFO_0021845
Disease	MASA syndrome (implicated_via_orthology)	L1CAM TRPM3	5.88e-04	7	158	2	DOID:0060246 (implicated_via_orthology)
Disease	Ovarian Mucinous Adenocarcinoma	RPS6KC1 TNK2 HCK	6.06e-04	31	158	3	C1335167
Disease	Intellectual Disability	NDST1 TREX1 GALT DOCK8 INPP5E SHANK3 TRPM3 LRP2 RAI1	7.14e-04	447	158	9	C3714756
Disease	X-11787 measurement	ALMS1 CLYBL	7.81e-04	8	158	2	EFO_0021258
Disease	Myopathies, Nemaline	NEB NEFL	7.81e-04	8	158	2	C0206157
Disease	myelofibrosis (is_implicated_in)	JAK2 KMT2A	7.81e-04	8	158	2	DOID:4971 (is_implicated_in)
Disease	metabolite measurement	GLYATL3 SHB ETFDH ZSWIM1 ATP10D CDKAL1 TINAGL1 ALMS1 LPL TBX20	9.13e-04	560	158	10	EFO_0004725
Disease	Profound Mental Retardation	NDST1 DOCK8 INPP5E SHANK3 RAI1	9.33e-04	139	158	5	C0020796
Disease	Mental Retardation, Psychosocial	NDST1 DOCK8 INPP5E SHANK3 RAI1	9.33e-04	139	158	5	C0025363
Disease	Mental deficiency	NDST1 DOCK8 INPP5E SHANK3 RAI1	9.33e-04	139	158	5	C0917816
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	PLIN2 JAK2 LPL	9.45e-04	36	158	3	DOID:0080208 (implicated_via_orthology)
Disease	glycosyl-N-palmitoyl-sphingosine (d18:1/16:0) measurement	GABRB1 ATP10D	1.00e-03	9	158	2	EFO_0800476
Disease	acute myeloid leukemia (is_implicated_in)	ETV6 CBL JAK2 KMT2A	1.09e-03	84	158	4	DOID:9119 (is_implicated_in)
Disease	Neurodevelopmental Disorders	DLGAP1 DOCK8 CHD2 KMT2A	1.60e-03	93	158	4	C1535926
Disease	Anxiety States, Neurotic	TG CNR1 RAI1	1.70e-03	44	158	3	C0376280
Disease	Anxiety neurosis (finding)	TG CNR1 RAI1	1.70e-03	44	158	3	C1279420
Disease	Anxiety Disorders	TG CNR1 RAI1	1.70e-03	44	158	3	C0003469
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	NDST1 ZFPM2	1.82e-03	12	158	2	DOID:3827 (implicated_via_orthology)
Disease	autoimmune thyroiditis (is_implicated_in)	TG LRP2	1.82e-03	12	158	2	DOID:7188 (is_implicated_in)
Disease	cerebral white matter volume change measurement	TMCC3 ADRA1D	1.82e-03	12	158	2	EFO_0021499
Disease	microphthalmia (implicated_via_orthology)	TRPM3 RBM24	1.82e-03	12	158	2	DOID:10629 (implicated_via_orthology)
Disease	Thromboembolism	JAK2 MERTK	1.82e-03	12	158	2	C0040038
Disease	Prostatic Neoplasms	NDST4 KLK3 GSK3B JAK2 NCOR1 VPS52 JMJD6 LPL LRP2 KMT2A	1.85e-03	616	158	10	C0033578
Disease	Malignant neoplasm of prostate	NDST4 KLK3 GSK3B JAK2 NCOR1 VPS52 JMJD6 LPL LRP2 KMT2A	1.85e-03	616	158	10	C0376358
Disease	tetralogy of Fallot (is_implicated_in)	ZFPM2 TBX20	2.14e-03	13	158	2	DOID:6419 (is_implicated_in)
Disease	leukemia (is_implicated_in)	ETV6 JAK2	2.14e-03	13	158	2	DOID:1240 (is_implicated_in)
Disease	Leukemia, Myelocytic, Acute	ETV6 CBL JAK2 KMT2A HSPB1	2.45e-03	173	158	5	C0023467
Disease	L2 Acute Lymphoblastic Leukemia	ETV6 KMT2A HCK	2.46e-03	50	158	3	C0023453
Disease	cholesterol efflux capacity measurement	CDKAL1 LPL	2.49e-03	14	158	2	EFO_0009132
Disease	Hamman-Rich syndrome	ABCA3 FAM13A	2.49e-03	14	158	2	C0085786
Disease	congenital hypothyroidism (implicated_via_orthology)	TG NEFL	2.49e-03	14	158	2	DOID:0050328 (implicated_via_orthology)
Disease	mean corpuscular hemoglobin concentration	FNDC3B ETV6 HNRNPUL1 NEB CDKAL1 ZGPAT NOP58 HECW2 LPL CLMP DOT1L RAB3IL1 PREX1 MPG	2.55e-03	1105	158	14	EFO_0004528
Disease	depressive disorder (biomarker_via_orthology)	L1CAM GSK3B NEFL	2.75e-03	52	158	3	DOID:1596 (biomarker_via_orthology)
Disease	Childhood Acute Lymphoblastic Leukemia	ETV6 KMT2A HCK	2.75e-03	52	158	3	C0023452
Disease	infant head circumference	CDKAL1 PREX1	2.86e-03	15	158	2	EFO_0004577
Disease	impotence (implicated_via_orthology)	P2RY1 CNR1	2.86e-03	15	158	2	DOID:1875 (implicated_via_orthology)
Disease	Schizophrenia	GABRB1 DLGAP1 SHANK3 GSK3B ADAMTS12 NEFL PEMT LPL LRP2 KMT2A CNR1 RAI1	2.94e-03	883	158	12	C0036341
Disease	3-hydroxypropylmercapturic acid measurement	ZFPM2 IGSF10 CLYBL TRPM3 LPL KMT2A HSPB1	2.97e-03	352	158	7	EFO_0007014
Disease	cholesterol to total lipids in large HDL percentage	ETFDH FAM13A LPL	3.22e-03	55	158	3	EFO_0022234
Disease	pulse pressure measurement	FNDC3B SHB ETFDH RNF213 CHD2 GPATCH8 CDKAL1 ZFPM2 PLIN2 ADRA1D FAM13A TRPM3 CSNK1G3 LPL DOT1L SOS2	3.35e-03	1392	158	16	EFO_0005763
Disease	non-Hodgkin lymphoma (is_implicated_in)	RAD54B KMT2A	3.68e-03	17	158	2	DOID:0060060 (is_implicated_in)
Disease	Acute myeloid leukemia	ETV6 JAK2	3.68e-03	17	158	2	cv:C0023467
Disease	Charcot-Marie-Tooth disease type 2	NEFL HSPB1	3.68e-03	17	158	2	cv:C0270914
Disease	LEUKEMIA, ACUTE MYELOID	ETV6 JAK2	3.68e-03	17	158	2	601626
Disease	open-angle glaucoma	FNDC3B ETFDH ZFPM2 FAM13A KMT2A	3.74e-03	191	158	5	EFO_0004190
Disease	cholesteryl esters to total lipids in large HDL percentage	ETFDH FAM13A LPL	3.93e-03	59	158	3	EFO_0022248
Disease	Brugada syndrome	ZFPM2 TBX20	4.59e-03	19	158	2	MONDO_0015263
Disease	Acute Myeloid Leukemia, M1	ETV6 JAK2 KMT2A HSPB1	4.64e-03	125	158	4	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	ETV6 JAK2 KMT2A HSPB1	4.64e-03	125	158	4	C1879321
Disease	myeloid white cell count	SPHK2 ARHGAP23 DOCK8 SLC38A9 INPP5E ZNF491 CDKAL1 ZFPM2 FAM13A DOT1L PREX1 FGF19	4.70e-03	937	158	12	EFO_0007988
Disease	transient cerebral ischemia (implicated_via_orthology)	CBL JAK2 KMT2A	4.94e-03	64	158	3	DOID:224 (implicated_via_orthology)
Disease	Obesity	INPP5E ETFDH LPL CNR1 RAI1	5.03e-03	205	158	5	C0028754
Disease	coronary artery disease	FNDC3B DOCK8 RNF213 CHD2 HNRNPUL1 ZFPM2 IGSF10 PEMT TRPM3 LPL MERTK TBX20 PREX1 RAI1	5.04e-03	1194	158	14	EFO_0001645
Disease	Deaf Mutism	TMTC2 AK2	5.08e-03	20	158	2	C4082305
Disease	Deafness, Acquired	TMTC2 AK2	5.08e-03	20	158	2	C0751068
Disease	Hearing Loss, Extreme	TMTC2 AK2	5.08e-03	20	158	2	C0086395
Disease	Complete Hearing Loss	TMTC2 AK2	5.08e-03	20	158	2	C0581883
Disease	Bilateral Deafness	TMTC2 AK2	5.08e-03	20	158	2	C3665473
Disease	Prelingual Deafness	TMTC2 AK2	5.08e-03	20	158	2	C0011052
Disease	Adenocarcinoma of lung (disorder)	RPS6KC1 NOP58 TNK2 DOT1L HSPB1	5.14e-03	206	158	5	C0152013

Protein segments in the cluster

Peptide	Gene	Start	Entry
TLKYTCLPGYVRSHS	C4BPA	76	P04003
TVLRYRCHPGYKPTT	C4BPA	326	P04003
ELYGEPRHTTYRSRS	AKAP9	3821	Q99996
PRHTTYRSRSDLDYI	AKAP9	3826	Q99996
SVTYATYRGPRHIGK	CRYBG3	226	Q68DQ2
YYRLDSTLGIHVDRS	ALKBH1	221	Q13686
YSHREKPIVSYQREL	ALMS1	1806	Q8TCU4
CKGSYEHRSRPIYVS	CACHD1	206	Q5VU97
LPLAVKYHLRFSYTR	ABCA3	146	Q99758
LPLSRDGYHTLQYKR	DLGAP1	111	O14490
TGKPVSYYLHTIDRT	DOT1L	306	Q8TEK3
LYRSGQKSEAYLPHT	ATP10D	1181	Q9P241
FLSYGLHYPITSSRR	ADAMTS12	66	P58397
GGPRSSLAYKYVIHE	ADAMTS14	816	Q8WXS8
PIVRDGKKVSSTHYY	TNK2	846	Q07912
GKKVSSTHYYLLPER	TNK2	851	Q07912
RLGYSSSSHHKYIPR	CLYBL	31	Q8N0X4
YIIHKYPSLELERRG	HP1BP3	186	Q5SSJ5
KSHYYISPSSRARIT	RAB3IL1	321	Q8TBN0
KRHGYAYTRLDGQTP	RAD54B	681	Q9Y620
RDGQKYPVHIYRLLT	RAD54B	756	Q9Y620
PGHTNYSSYSKRKRL	RAI1	1526	Q7Z5J4
GGLPYHTTDASLRKY	RBM24	16	Q9BX46
IRDGVRAYTALHYLS	CRYZL1	126	O95825
YLGTKRYIHRDLATR	JAK2	966	O60674
LPETHRRVRLYKYGT	PARD6B	151	Q9BYG5
LHYSRVYPESIPRKF	RADX	696	Q6NSI4
KYYHGISGALRATTP	HECW2	141	Q9P2P5
LLTKEDFRYRSPHSG	ETV6	96	P41212
IHTVGPKYKSRYRTA	GDAP2	126	Q9NXN4
SRRDTPKYGLIYHAS	NOP58	331	Q9Y2X3
LLYYVASTTRRPHAV	OTOP3	136	Q7RTS5
SAHRYSGVVYPLKSL	P2RY1	146	P47900
HRKYYQDKTGTVPRV	FAM166C	121	A6NJV1
RSYAVRVGDYHTLVP	PRSS12	686	P56730
HALPVYVFTRPTYSR	HYAL2	286	Q12891
YIFDSSYGEHPKRRK	JMJD6	131	Q6NYC1
YRIVSYTRDLPHITV	MMP7	111	P09237
ILGYRKPTVTHVHYR	LPGAT1	271	Q92604
LRLLASYPHTRDVYV	LFNG	211	Q8NES3
TPSYTDRVLYRSRHK	INPP5E	551	Q9NRR6
TYLLYSRLETGPKHI	MERTK	681	Q12866
RSKGRFPVLSYYHQD	MTMR6	181	Q9Y217
QRHPRGYTVYKVTAR	RPS6KC1	21	Q96S38
GTDPSKHYISVYRSL	KCNK16	221	Q96T55
EYYRNKHSSKPIRVI	GAB3	46	Q8WWW8
KYYHGVSGALRATTP	HECW1	161	Q76N89
HTQTTPLIEYYRKRG	AK2	191	P54819
PLIEYYRKRGIHSAI	AK2	196	P54819
RRLRHGSSSYPPVIY	ZFPM2	526	Q8WW38
IRSKIYRSQSPHYFR	GPATCH8	1026	Q9UKJ3
RAQEHYPVSAGYTKL	LPL	116	P06858
PLSYRSLPHTRTSKY	L3MBTL1	601	Q9Y468
IRPDGYNVYRSEKHR	FGF19	126	O95750
YNVYRSEKHRLPVSL	FGF19	131	O95750
TSTEEYPHLKPARYR	NDST1	456	P52848
LSPTERLYAYHLSRA	DPP3	26	Q9NY33
TLKLSPYVHYTFRVT	L1CAM	676	P32004
ILSGLRPYSSYHLEV	L1CAM	881	P32004
SIQYRKPLSSREAYG	GABRB1	401	P18505
HGYISRCFTRKYTLP	HSPB1	131	P04792
DYLASLRPRLHSIYV	NAGS	406	Q8N159
ASLRPYGVTVYHSLR	LRP2	641	P98164
VADRLYPAGSTIYRH	MUC5AC	4786	P98088
YNRGPITHLEYKTSF	AP5M1	361	Q9H0R1
VHQDGKPRYSYATLI	FOXJ2	61	Q9P0K8
TSTEEYPHLKPARYR	NDST4	446	Q9H3R1
ALLYYESIHGRPVTK	FAM13A	811	O94988
IPYREHKSLTGTARY	CSNK1G3	201	Q9Y6M4
ISYKPRLHTTYEFPV	OOSP4B	81	A0A2R8Y4Y8
PKRTSNTVYLDYRPH	MANEA	416	Q5SRI9
TREQGPSRHVYLTYE	MED14	736	O60244
YRGLPKHTYALVTCG	F2RL2	201	O00254
EHKTRKLSRAFGSPY	PEMT	36	Q9UBM1
YKPLFLDRGYTSALH	PRR7	201	Q8TB68
VSLYYPAGLSHRRVS	ITGAD	816	Q13349
ARSLVVPAYAYRKLH	NEU2	171	Q9Y3R4
LLGVSRRHSRPYPSY	OPN4	371	Q9UHM6
YTLPEHRRKGYSRLV	GLYATL3	216	Q5SZD4
TLSLKHTSAGPRYQY	B3GNT5	61	Q9BYG0
YLSRYQDTHPERLAK	GMPPA	261	Q96IJ6
RITTHYTIYPRDKDK	ETFDH	41	Q16134
TKGSYSLSVRDYDPR	HCK	176	P08631
LTAPYYGSRITVHKN	IGSF10	2281	Q6WRI0
YKHGYIASRVLSRRA	GKN2	66	Q86XP6
PTALLDPRSYHTYGR	DOCK8	871	Q8NF50
YLTIKHYPFQRLDGS	CHD2	826	O14647
RTKDLSRVFHSYSPY	CDKAL1	416	Q5VV42
NKRFISIYRGPSHTY	FNDC3B	1001	Q53EP0
SIYRGPSHTYKVQRL	FNDC3B	1006	Q53EP0
HYYPPLLRSATVRKF	GALT	321	P07902
KYTHFTSPIRRYSDI	DIS3L	791	Q8TF46
LKLSHGDYYRKRPTL	ARFGEF3	746	Q5TH69
TTVHDRLYGYRTLPG	C9orf43	336	Q8TAL5
PETVYRVARHYSRAK	GSK3B	136	P49841
EEIRCRKYLHPSSYT	CUL2	246	Q13617
YRSIYFSSPKGHLTR	MPG	71	P29372
AIDRYISIHRPLAYK	CNR1	211	P21554
SGSCYYHVISKVPRI	KMT2A	2131	Q03164
YHVISKVPRIRTPSY	KMT2A	2136	Q03164
TYQHLRTILSRYEGK	CBL	91	P22681
YHTVSYPARTRKVIV	GPR139	136	Q6DWJ6
KRIHYYSRLTTPADK	SLC38A9	66	Q8NBW4
ASHYERKPLSSVYRP	PRIMPOL	16	Q96LW4
HFKVARDRSSGYPLT	HNRNPUL1	221	Q9BUJ2
GHPYYLRSFLVVLKT	FAN1	371	Q9Y2M0
SSRSKYIPLYTGHVQ	SPATA48	316	A4D263
RIHIYGRYSQEPIKT	UTP15	61	Q8TED0
DRGIVYSKSLDRHLY	SORT1	381	Q99523
YSHTPVSLGRPERYR	TINAGL1	381	Q9GZM7
HRLPTTGYLVYRRAE	RIN1	691	Q13671
IPVYVGRKIHSRYEG	RNF19B	376	Q6ZMZ0
VIHYYTTRKLPIKGA	SHB	481	Q15464
TRLPGYSSAEYRLKE	SOS2	476	Q07890
TALTVDRTYSYPGRH	TMCC3	6	Q9ULS5
TLHYDRYTTSRRLDP	SARAF	46	Q96BY9
TRLYRRHYTLDASLP	TMEM183BP	171	Q1AE95
RVSGKDLVPNHLSYY	LARS1	671	Q9P2J5
GTPVSGYALYQRHIK	NCOR1	951	O75376
LYSDLHTPGRYGRVI	PTCHD4	101	Q6ZW05
DRDYHLKTYKSVLPG	PREX1	531	Q8TCU6
LKSLHREYSGRRQPY	SLC25A42	211	Q86VD7
VTVYHRRGSRSYVPL	PMEL	186	P40967
RLSEKPPYSKYSSRH	PHLDB2	141	Q86SQ0
GKKVSSTHYYLLPER	ERRFI1	386	Q9UJM3
VIDGHRKVSDRFYPY	EXTL1	471	Q92935
PGLYRYTSEDAILKH	ROBO4	501	Q8WZ75
SVDRYVGVRHSLKYP	ADRA1D	191	P25100
SYYVGTLGTHTEIKR	CLMP	11	Q9H6B4
SIPEHGRLSRKYIYS	CNGA3	341	Q16281
AYGTRRHLYDPKLGT	CNN1	181	P51911
SLVYHRRLHTGEKPY	ZNF845	481	Q96IR2
SKIAKYPHVEDYRRT	PSME3	191	P61289
SYKHPYRQGEVVLTT	TECTA	1941	O75443
AYLAGHYRVPKQTLS	RNF213	1961	Q63HN8
GLDTRPHYITRRYAE	VPS52	501	Q8N1B4
KIFSIYGHYPVVRAA	TTLL8	56	A6PVC2
ELYRVSKEYTHSRPQ	TNFAIP8L2	41	Q6P589
HYTAYVKVRTPSRKL	USP45	746	Q70EL2
YRTALKLYPRHASAL	TMTC1	506	Q8IUR5
TRLYRRHYTLDASLP	TMEM183A	171	Q8IXX5
LATLHTYRGRLSYLP	SPHK2	366	Q9NRA0
YKDSRGLTPLYHSAL	SHANK3	211	Q9BYB0
SRYDITGLHPGTEYK	TNN	406	Q9UQP3
GLPKAAIVVHSRYYR	SLC27A4	251	Q6P1M0
APKYDHSYLGSARER	ILDR2	521	Q71H61
PMYHTIERSKSSRYL	TRPM3	1516	Q9HCF6
LTVHYRTHSGEKPYE	RBAK	666	Q9NYW8
TLRKLIRDLPGHYYE	ARHGAP23	1016	Q9P227
ALHYYKLAIGSRPTL	TMTC2	546	Q8N394
THDYPYSLVSRELRG	TMEM214	166	Q6NUQ4
LYPETSRKYRPRVEH	TOR4A	101	Q9NXH8
SYLRHERTHTGEKPY	ZNF442	251	Q9H7R0
YIRIHGRTHTGEKPY	ZNF491	341	Q8N8L2
SLIYHRRLHTGEKSY	ZNF611	636	Q8N823
YYVRLGSLSTKLHSR	PLIN2	216	Q99541
YSRTLKEEGPRYLSS	SLC35A3	26	Q9Y2D2
HKFSAGTYPRLEEYR	SYCN	101	Q0VAF6
KHSYARSPIRTYGGE	TBX20	306	Q9UMR3
SYLTVHYRTHSGEKP	ZNF12	646	P17014
IHRTYNPRGKVLYTF	ZSWIM1	81	Q9BR11
HGPRKSYSLGSIYTR	TREX1	171	Q9NSU2
THIYRKPGISLLSYE	TG	2181	P01266
YLKYEPGAVELSRRH	TMEM38A	36	Q9H6F2
GSAGVRVLYLYPTHK	ZGPAT	161	Q8N5A5
HYRETGYPLAVKLGT	USP5	236	P45974
RGYTSKSYLTVHERT	ZNF337	271	Q9Y3M9
LPERPSLYTKVVHYR	KLK3	236	P07288
IYSPQFSRLYHGVKR	MYO3B	391	Q8WXR4
PARIYLRALGKHSTY	ART1	261	P52961
YDYVHSVRGKVAPTT	NEB	4916	P20929
STSYKRRYVETPRVH	NEFL	11	P07196