Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	IRSp53/IRTKS/Pinkbar	BAIAP2 BAIAP2L1	9.64e-06	3	34	2	IPR027681
Domain	IMD	BAIAP2 BAIAP2L1	3.21e-05	5	34	2	PS51338
Domain	IMD	BAIAP2 BAIAP2L1	4.80e-05	6	34	2	PF08397
Domain	I-BAR_dom	BAIAP2 BAIAP2L1	2.48e-04	13	34	2	IPR013606
Domain	SH3	MACF1 BAIAP2 BAIAP2L1	7.01e-03	216	34	3	PS50002
Domain	SH3_domain	MACF1 BAIAP2 BAIAP2L1	7.37e-03	220	34	3	IPR001452
Domain	SH3_9	BAIAP2 BAIAP2L1	8.86e-03	78	34	2	PF14604
Domain	EF-hand_7	MACF1 SDF4	1.04e-02	85	34	2	PF13499
Domain	SH3_2	BAIAP2 BAIAP2L1	1.07e-02	86	34	2	IPR011511
Domain	SH3_2	BAIAP2 BAIAP2L1	1.07e-02	86	34	2	PF07653
Pubmed	Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation.	BAIAP2 BAIAP2L1	9.28e-07	2	34	2	19366662
Pubmed	IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions.	BAIAP2 BAIAP2L1	2.78e-06	3	34	2	18215522
Pubmed	G-quadruplexes in the BAP1 promoter positively regulate its expression.	CHD2 BAP1	2.78e-06	3	34	2	29787736
Pubmed	Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties.	BAIAP2 BAIAP2L1	5.56e-06	4	34	2	17430976
Pubmed	A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.	BAIAP2 BAIAP2L1	5.56e-06	4	34	2	14752106
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	MPL MACF1	5.56e-06	4	34	2	8954775
Pubmed	Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.	MPL MACF1	1.39e-05	6	34	2	9878243
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FAM169A KDM3B CHD2 MGA EXOSC2 BAP1	2.47e-05	608	34	6	36089195
Pubmed	The EHEC-host interactome reveals novel targets for the translocated intimin receptor.	BAIAP2 BAIAP2L1	4.15e-05	10	34	2	25519916
Pubmed	Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.	MPL MACF1	5.07e-05	11	34	2	10721728
Pubmed	Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.	BAIAP2 BAIAP2L1	8.38e-05	14	34	2	28067313
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MACF1 SRPK2 SDF4 ARHGEF33 MGA BRWD3 ISY1	8.66e-05	1116	34	7	31753913
Pubmed	A human MAP kinase interactome.	MACF1 BAIAP2 CDC42EP4 MGA MOB4	1.04e-04	486	34	5	20936779
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	SDF4 CHD2 BAIAP2 BAIAP2L1 MGA	1.60e-04	533	34	5	30554943
Pubmed	Functional proteomics mapping of a human signaling pathway.	KDM3B MACF1 SDF4 STX16 MGA	2.58e-04	591	34	5	15231748
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	KDM3B MGA BAP1	3.07e-04	134	34	3	25452129
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MACF1 GRIA4 SRPK2 BAIAP2 MGA MOB4	3.07e-04	963	34	6	28671696
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	MACF1 BAIAP2 CDC42EP4 STX16	3.57e-04	347	34	4	17114649
Pubmed	Accessory subunits are integral for assembly and function of human mitochondrial complex I.	NDUFB11 NDUFB5	4.52e-04	32	34	2	27626371
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MACF1 SRPK2 CHD2 NADSYN1 BAIAP2 NDUFB5 BRWD3	5.06e-04	1489	34	7	28611215
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	KDM3B NDUFB11 SDF4 NDUFB5 PIGS	5.10e-04	686	34	5	28380382
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	NDUFB11 MACF1 SDF4 STX16 MOB4 PIGS	5.14e-04	1061	34	6	33845483
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MACF1 SRPK2 CHD2 HIP1 BAIAP2 STX16 EXOSC2	5.22e-04	1497	34	7	31527615
Pubmed	The protein interaction landscape of the human CMGC kinase group.	SRPK2 SDF4 CHD2 BAIAP2 CDC42EP4	5.41e-04	695	34	5	23602568
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	MACF1 BAIAP2 CDC42EP4 BAIAP2L1 EXOSC2	6.31e-04	719	34	5	35337019
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MACF1 BAIAP2 MGA EXOSC2 ISY1	6.51e-04	724	34	5	36232890
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	SRPK2 BAIAP2 BAIAP2L1 MGA	6.67e-04	410	34	4	26949251
Pubmed	Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.	GRIA4 BRWD3	6.72e-04	39	34	2	24095980
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	MACF1 CDC42EP4 STX16 BAIAP2L1	7.36e-04	421	34	4	36976175
Pubmed	The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.	NDUFB11 NDUFB5	7.79e-04	42	34	2	12611891
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	MACF1 GRIA4 HIP1 BAIAP2	7.97e-04	430	34	4	32581705
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	KDM3B BAIAP2 CDC42EP4 BAIAP2L1 MGA	8.93e-04	777	34	5	35844135
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	MACF1 GRIA4 BAIAP2	9.41e-04	197	34	3	36604605
Interaction	RHOF interactions	FAM169A MACF1 HIP1 BAIAP2 CDC42EP4 STX16 BAIAP2L1 PIGS	1.25e-05	673	34	8	int:RHOF
Interaction	ARL8B interactions	KDM3B SDF4 IL17RC BAIAP2 MINDY2	2.22e-05	204	34	5	int:ARL8B
GeneFamily	I-BAR domain containing	BAIAP2 BAIAP2L1	1.98e-05	5	26	2	1287
GeneFamily	NADH:ubiquinone oxidoreductase supernumerary subunits	NDUFB11 NDUFB5	8.44e-04	30	26	2	1150
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAM169A KDM3B GRIA4 CDC42EP4	1.05e-05	180	34	4	c72f15763ba707189e29c85db533557f01c7fdb1
Disease	response to radiation	KDM3B SNUPN BRWD3	1.31e-04	88	33	3	GO_0009314
Disease	autism spectrum disorder, schizophrenia	KDM3B SRPK2 HLA-DQA2 MOB4	4.70e-04	327	33	4	EFO_0003756, MONDO_0005090
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	KDM3B SRPK2 MOB4	1.44e-03	200	33	3	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351

Protein segments in the cluster

Peptide	Gene	Start	Entry
PDGDGHVSWDEYKVK	SDF4	151	Q9BRK5
GKEWGEEYVTKDHPD	ARHGEF33	226	A8MVX0
LKVYPIDHGPWGEDE	BAP1	186	Q92560
YKPQEGEWGAHSRDE	BRWD3	1131	Q6RI45
IYDCKVEHWGLDEPL	HLA-DQA2	186	P01906
HYPLWVKVEGEVDPE	MGA	1156	Q8IWI9
HWEVRIKELGGPDYG	ISY1	86	Q9ULR0
YEWHTEEPEDGKEGP	GRIA4	571	P48058
HRVKIYQPEGEEGWL	KDM3B	201	Q7LBC6
GFIWIYPTPEHKEEE	EXOSC2	201	Q13868
YHPNDVEEEWGKLII	MACF1	396	Q9UPN3
IPEEKDGWLYGEHDV	BAIAP2L1	371	Q9UHR4
EAEGEKWGLVPTHAY	CAPN7	446	Q9Y6W3
HGYGNWELIKTDPEL	CHD2	1276	O14647
DKEEWDPEEGEGGYH	CDC42EP4	226	Q9H3Q1
KYPGDHELLWEVEGV	FAM169A	231	Q9Y6X4
PDSHGYDKDPVLDVW	NDUFB11	71	Q9NX14
HWEEPEDEEKFGGAA	IL17RC	166	Q8NAC3
PDPKSHDVYWDIEGA	PIGS	236	Q96S52
YHGWLVDPQIDDIVK	MINDY2	366	Q8NBR6
PEGQDEGVWKYEHLR	MOB4	61	Q9Y3A3
KKHYELAGVAEGWEE	HIP1	1006	O00291
YWMHSKLPEEEGLGE	SNUPN	206	O95149
VPEARDGWHYGESEK	BAIAP2	406	Q9UQB8
KVYALDETWHPDLGE	CHRD	56	Q9H2X0
HGPWIDEEYKIRGVL	NLRP9	976	Q7RTR0
EKEGIHVLDWPFDDG	PTP4A2	56	Q12974
PKWVDGVDEIQYDVG	STX16	76	O14662
LFDVLVEKYGWPHED	SRPK2	641	P78362
AELAEIPEGYVPEHW	NDUFB5	96	O43674
SEGEHYWEVDVGDKP	TRIM72	341	Q6ZMU5
RYTGEGHQDWKVLEP	MPL	426	P40238
KEIWEEGPREYVLHL	TRPC7	456	Q9HCX4
IEWKYHSPEEEISLG	NADSYN1	321	Q6IA69