Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

CAPN13 FBLN2 MEGF8 CIB3 VCAN NCAN LRP2 CDH23 CLSTN1 GSN

1.26e-047496410GO:0005509
GeneOntologyMolecularFunctionpolysaccharide binding

CLEC18A CLEC18B CLEC18C

1.32e-0431643GO:0030247
GeneOntologyMolecularFunctioncarbohydrate binding

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

4.69e-04310646GO:0030246
GeneOntologyCellularComponentextracellular matrix

FBLN2 FCGBP MAMDC2 VCAN NCAN GPC4 COL5A3 FGG GPC6

1.86e-04656659GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

FBLN2 FCGBP MAMDC2 VCAN NCAN GPC4 COL5A3 FGG GPC6

1.90e-04658659GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

FBLN2 MAMDC2 VCAN NCAN GPC4 COL5A3 FGG GPC6

2.30e-04530658GO:0062023
GeneOntologyCellularComponentlysosomal lumen

VCAN NCAN GPC4 GPC6

2.47e-0498654GO:0043202
GeneOntologyCellularComponentGolgi lumen

VCAN NCAN GPC4 GPC6

3.71e-04109654GO:0005796
GeneOntologyCellularComponentperineuronal net

VCAN NCAN

4.22e-0410652GO:0072534
GeneOntologyCellularComponentperisynaptic extracellular matrix

VCAN NCAN

5.14e-0411652GO:0098966
GeneOntologyCellularComponentcell surface

PROM2 VCAN PKD1 GPC4 TMPRSS11D LRP2 IL17RC FGG GPC6 CLSTN1 TFR2

5.79e-0411116511GO:0009986
GeneOntologyCellularComponentsynapse-associated extracellular matrix

VCAN NCAN

7.26e-0413652GO:0099535
GeneOntologyCellularComponentFAR/SIN/STRIPAK complex

STRIP2 STRIP1

1.26e-0317652GO:0090443
GeneOntologyCellularComponentconnexin complex

GJA9 GJA10

2.11e-0322652GO:0005922
GeneOntologyCellularComponentvacuolar lumen

VCAN NCAN GPC4 GPC6

2.30e-03178654GO:0005775
DomainEGF

CLEC18A FBLN2 FCGBP CLEC18B MEGF8 VCAN NCAN LRP2 CLEC18C

1.18e-07235659SM00181
DomainEGF-like_dom

CLEC18A FBLN2 FCGBP CLEC18B MEGF8 VCAN NCAN LRP2 CLEC18C

1.92e-07249659IPR000742
DomainC_TYPE_LECTIN_1

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

3.45e-0780656PS00615
DomainC-type_lectin_CS

CLEC18A CLEC18B VCAN NCAN CLEC18C

3.79e-0743655IPR018378
DomainLectin_C

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

4.61e-0784656PF00059
DomainCLECT

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

4.61e-0784656SM00034
DomainC_TYPE_LECTIN_2

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

4.95e-0785656PS50041
DomainC-type_lectin-like

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

5.31e-0786656IPR001304
Domain-

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

1.08e-06976563.10.100.10
DomainC-type_lectin-like/link

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

1.22e-0699656IPR016186
DomainEGF_3

CLEC18A FBLN2 CLEC18B MEGF8 VCAN NCAN LRP2 CLEC18C

1.52e-06235658PS50026
DomainCTDL_fold

CLEC18A CLEC18B VCAN NCAN PKD1 CLEC18C

1.93e-06107656IPR016187
DomainEGF_1

CLEC18A FBLN2 CLEC18B MEGF8 VCAN NCAN LRP2 CLEC18C

2.79e-06255658PS00022
DomainEGF-like_CS

CLEC18A FBLN2 CLEC18B MEGF8 VCAN NCAN LRP2 CLEC18C

3.31e-06261658IPR013032
DomainEGF_2

CLEC18A FBLN2 CLEC18B MEGF8 VCAN NCAN LRP2 CLEC18C

3.71e-06265658PS01186
DomainDUF3402

STRIP2 STRIP1

1.19e-052652PF11882
DomainN1221

STRIP2 STRIP1

1.19e-052652PF07923
DomainDUF3402

STRIP2 STRIP1

1.19e-052652IPR021819
DomainDUF3402

STRIP2 STRIP1

1.19e-052652SM01293
DomainN1221

STRIP2 STRIP1

1.19e-052652SM01292
DomainN1221

STRIP2 STRIP1

1.19e-052652IPR012486
Domain-

CLEC18A CLEC18B CLEC18C

1.78e-05156533.40.33.10
DomainCAP

CLEC18A CLEC18B CLEC18C

1.78e-0515653PF00188
DomainCAP_domain

CLEC18A CLEC18B CLEC18C

1.78e-0515653IPR014044
DomainSCP

CLEC18A CLEC18B CLEC18C

1.78e-0515653SM00198
DomainAllrgn_V5/Tpx1

CLEC18A CLEC18B CLEC18C

1.78e-0515653IPR001283
DomainEGF_Ca-bd_CS

FBLN2 MEGF8 VCAN NCAN LRP2

2.20e-0597655IPR018097
DomainLDLRA_1

TMPRSS15 PKD1 LRP2 RXFP1

2.32e-0548654PS01209
DomainEGF_CA

FBLN2 MEGF8 VCAN NCAN LRP2

2.43e-0599655PS01187
DomainLDLRA_2

TMPRSS15 PKD1 LRP2 RXFP1

2.52e-0549654PS50068
DomainASX_HYDROXYL

FBLN2 MEGF8 VCAN NCAN LRP2

2.55e-05100655PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN2 MEGF8 VCAN NCAN LRP2

3.37e-05106655IPR000152
DomainEGF_CA

FBLN2 MEGF8 VCAN NCAN LRP2

6.61e-05122655SM00179
DomainEGF-like_Ca-bd_dom

FBLN2 MEGF8 VCAN NCAN LRP2

7.15e-05124655IPR001881
DomainConA-like_dom

TMPRSS15 MAMDC2 NBEAL2 COL5A3 TRIM65 CLSTN1

1.13e-04219656IPR013320
DomainGLYPICAN

GPC4 GPC6

1.77e-046652PS01207
DomainGlypican

GPC4 GPC6

1.77e-046652IPR001863
DomainGlypican

GPC4 GPC6

1.77e-046652PF01153
DomainGlypican_CS

GPC4 GPC6

1.77e-046652IPR019803
DomainVillin/Gelsolin

CAPG GSN

3.29e-048652IPR007122
DomainGEL

CAPG GSN

3.29e-048652SM00262
DomainLDLR_class-A_CS

TMPRSS15 LRP2 RXFP1

3.63e-0440653IPR023415
DomainLdl_recept_a

TMPRSS15 LRP2 RXFP1

5.14e-0445653PF00057
Domain-

TMPRSS15 LRP2 RXFP1

5.49e-04466534.10.400.10
DomainLDrepeatLR_classA_rpt

TMPRSS15 LRP2 RXFP1

6.61e-0449653IPR002172
DomainLDLa

TMPRSS15 LRP2 RXFP1

6.61e-0449653SM00192
DomainLINK

VCAN NCAN

9.08e-0413652SM00445
DomainLink_dom

VCAN NCAN

9.08e-0413652IPR000538
DomainXlink

VCAN NCAN

9.08e-0413652PF00193
DomainLINK_1

VCAN NCAN

9.08e-0413652PS01241
DomainLINK_2

VCAN NCAN

9.08e-0413652PS50963
DomainGelsolin

CAPG GSN

1.06e-0314652PF00626
DomainSEA

TMPRSS15 TMPRSS11D

1.06e-0314652SM00200
DomainGelsolin-like_dom

CAPG GSN

1.06e-0314652IPR007123
DomainTIL_dom

FCGBP LRP2

1.06e-0314652IPR002919
Domain-

TMPRSS15 TMPRSS11D

1.22e-03156523.30.70.960
DomainMAM_1

TMPRSS15 MAMDC2

1.39e-0316652PS00740
DomainMAM

TMPRSS15 MAMDC2

1.57e-0317652SM00137
DomainMAM

TMPRSS15 MAMDC2

1.76e-0318652PF00629
DomainMAM_dom

TMPRSS15 MAMDC2

1.76e-0318652IPR000998
DomainMAM_2

TMPRSS15 MAMDC2

1.76e-0318652PS50060
DomainCONNEXINS_1

GJA9 GJA10

1.96e-0319652PS00407
DomainCONNEXINS_2

GJA9 GJA10

2.18e-0320652PS00408
DomainConnexin

GJA9 GJA10

2.18e-0320652IPR000500
DomainConnexin_CCC

GJA9 GJA10

2.18e-0320652IPR019570
DomainConnexin_N

GJA9 GJA10

2.18e-0320652IPR013092
DomainConnexin

GJA9 GJA10

2.18e-0320652PF00029
DomainConnexin_CCC

GJA9 GJA10

2.18e-0320652SM01089
DomainConnexin_CS

GJA9 GJA10

2.18e-0320652IPR017990
DomainCNX

GJA9 GJA10

2.18e-0320652SM00037
DomainSEA

TMPRSS15 TMPRSS11D

2.63e-0322652PF01390
DomainSEA

TMPRSS15 TMPRSS11D

2.88e-0323652PS50024
DomainSEA_dom

TMPRSS15 TMPRSS11D

2.88e-0323652IPR000082
DomainADF-H/Gelsolin-like_dom

CAPG GSN

3.13e-0324652IPR029006
Domain-

CAPG GSN

3.13e-03246523.40.20.10
DomainEGF_CA

FBLN2 MEGF8 LRP2

3.35e-0386653PF07645
PathwayREACTOME_DEFECTIVE_B4GALT7_CAUSES_EDS_PROGEROID_TYPE

VCAN NCAN GPC4 GPC6

3.51e-0720434M27258
PathwayREACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS

VCAN NCAN GPC4 GPC6

1.07e-0626434M708
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSAMINOGLYCAN_METABOLISM

VCAN NCAN GPC4 GPC6

7.00e-0641434M27257
PathwayREACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

VCAN NCAN GPC4 GPC6

1.56e-0550434M678
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

VCAN NCAN GPC4 GPC6

2.64e-0557434M692
PathwayREACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS

VCAN GPC4 GPC6

5.12e-0524433MM14773
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

GPC4 LRP2 GNB1 GPC6

1.73e-0492434MM14881
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

GPC4 LRP2 GNB1 GPC6

2.38e-04100434M27158
PathwayREACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE

VCAN NCAN

2.52e-048432M27260
PathwayREACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS

VCAN NCAN

2.52e-048432M27261
PathwayREACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD

VCAN NCAN

2.52e-048432M27259
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

CAPN13 FBLN2 VCAN NCAN COL5A3 FGG

2.78e-04300436M610
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

GPC4 LRP2 GPC6

3.43e-0445433MM15344
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

GPC4 LRP2 GPC6

4.16e-0448433M27642
PathwayREACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

VCAN GPC4 GPC6

4.16e-0448433MM14696
PathwayREACTOME_DERMATAN_SULFATE_BIOSYNTHESIS

VCAN NCAN

4.91e-0411432M27105
PathwayREACTOME_GLYCOSAMINOGLYCAN_METABOLISM

VCAN NCAN GPC4 GPC6

5.73e-04126434M695
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

VCAN GPC4 GPC6

5.88e-0454433MM14633
PathwayREACTOME_DEFECTIVE_EXT2_CAUSES_EXOSTOSES_2

GPC4 GPC6

8.08e-0414432M27263
PathwayREACTOME_CS_DS_DEGRADATION

VCAN NCAN

8.08e-0414432M651
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

VCAN NCAN GPC4 GPC6

9.22e-04143434M27275
PathwayREACTOME_DISEASES_OF_METABOLISM

VCAN NCAN GPC4 ACY1 GPC6

9.36e-04250435M27554
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

CAPN13 FBLN2 VCAN COL5A3 FGG

1.08e-03258435MM14572
PathwayBIOCARTA_GCR_PATHWAY

NR3C1 NOS3

1.20e-0317432M10066
PathwayBIOCARTA_GCR_PATHWAY

NR3C1 NOS3

1.20e-0317432MM1372
PathwayWP_MIR5093P_ALTERATION_OF_YAP1ECM_AXIS

TEAD1 GPC6

1.35e-0318432M39421
PathwayREACTOME_ATTACHMENT_AND_ENTRY

GPC4 GPC6

1.50e-0319432M41729
PathwayREACTOME_ECM_PROTEOGLYCANS

VCAN NCAN COL5A3

1.59e-0376433M27219
PathwayREACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS

VCAN NCAN

1.67e-0320432M658
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

FCGBP PMVK MEGF8 CCT5 PROM2 CAPG PKD1 TMPRSS11D LRP2 FGG GNB1 ACY1 HNMT GSN STRIP1

4.61e-101016651519056867
Pubmed

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

CLEC18A CLEC18B CLEC18C

6.23e-09365326170455
Pubmed

The C-type lectin-like domain superfamily.

CLEC18A CLEC18B CLEC18C

6.23e-09365316336259
Pubmed

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.

CLEC18A CLEC18B CLEC18C

6.23e-09365333603190
Pubmed

The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.

CLEC18A CLEC18B CLEC18C

2.49e-08465316709836
Pubmed

The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.

VCAN NCAN GPC4 GPC6

4.94e-073465432220631
Pubmed

Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae.

STRIP2 STRIP1

3.44e-06265212588993
Pubmed

Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing.

CAPG GSN

3.44e-06265211514591
Pubmed

TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae.

STRIP2 STRIP1

3.44e-06265222298706
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

FBLN2 VCAN CAPG GPC4 CLSTN1 GSN

7.19e-0624865624006456
Pubmed

The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.

STRIP2 STRIP1

1.03e-05365222782902
Pubmed

Differential developmentally regulated expression of gelsolin family members in the mouse.

CAPG GSN

1.03e-05365210417819
Pubmed

Relaxin receptors 1 and 2 and nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) mRNAs are expressed in oral components of developing mice.

RXFP1 NR3C1

1.03e-05365224370181
Pubmed

The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.

STRIP2 STRIP1

1.03e-05365230509168
Pubmed

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.

GPC4 GPC6

1.03e-05365222722203
Pubmed

Glucocorticoid receptor agonist dexamethasone attenuates renal ischemia/reperfusion injury by up-regulating eNOS/iNOS.

NR3C1 NOS3

1.03e-05365225135720
Pubmed

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.

PKD1 CDH23

1.03e-05365221865467
Pubmed

Prognostic evaluation of CapG, gelsolin, P-gp, GSTP1, and Topo-II proteins in non-small cell lung cancer.

CAPG GSN

1.03e-05365222190510
Pubmed

Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations.

FBLN2 VCAN

2.06e-0546529676579
Pubmed

Expression of connexin genes in the human retina.

GJA9 GJA10

2.06e-05465220979653
Pubmed

Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly.

CCT5 GNB1

2.06e-05465215889144
Pubmed

A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload.

PKD1 NOS3

2.06e-05465220554900
Pubmed

G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.

NR3C1 GNB1

2.06e-05465215955845
Pubmed

Lecticans: organizers of the brain extracellular matrix.

VCAN NCAN

2.06e-05465210766023
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

CLEC18A CLEC18B PROM2 NBEAL2 GPC4 CLEC18C GPC6

2.43e-0546065720562862
Pubmed

The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.

FBLN2 VCAN

3.43e-05565211038354
Pubmed

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.

PKD1 GGA1

3.43e-05565225405894
Pubmed

A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.

CAPG GSN

3.43e-05565218266911
Pubmed

Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.

VCAN NCAN

3.43e-0556529716537
Pubmed

L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages.

CAPG GSN

3.43e-05565224236012
Pubmed

The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development.

VCAN NR3C1

3.43e-05565212495930
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

MEGF8 PKD1 LRP2 ICA1L

3.81e-0510065425807483
Pubmed

Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.

CLEC18A CLEC18B CLEC18C

4.63e-053765322432025
Pubmed

Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.

VCAN GPC4 GPC6

4.63e-053765332201365
Pubmed

Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.

GJA9 GJA10

5.13e-05665212881038
Pubmed

Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.

GPC4 GPC6

5.13e-05665223911103
Pubmed

K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney.

GPC4 GPC6

5.13e-0566527657705
Pubmed

STRIPAK components determine mode of cancer cell migration and metastasis.

STRIP2 STRIP1

5.13e-05665225531779
Pubmed

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.

VCAN NCAN

7.18e-05765221976490
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

CLEC18A CLEC18B PROM2 NBEAL2 GPC4 CDH23 IL17RC GPC6 GPN3

8.72e-0598565912975309
Pubmed

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

CCT5 STRIP2 STRIP1

8.93e-054665318782753
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KIDINS220 MEGF8 KIAA0232 MED13L STRIP2 STRIP1

1.14e-0440765612693553
Pubmed

Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.

VCAN NCAN

1.53e-04106529184108
Pubmed

Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain.

GPC4 GPC6

1.53e-041065217107664
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

FCGBP MEGF8 PROM2 CAPG LRP2 FGG GNB1 ACY1 GSN

1.63e-04107065923533145
Pubmed

PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.

GPC4 GPC6

1.87e-041165225624497
Pubmed

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis.

PMVK PEX5

1.87e-041165211792727
Pubmed

Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.

VCAN GPC6

1.87e-041165238750698
Pubmed

Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development.

GPC4 GPC6

2.24e-041265212761845
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

FBLN2 VCAN COL5A3 FGG

2.76e-0416765422159717
Pubmed

Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis.

GPC4 GPC6

3.08e-041465237408198
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

FBLN2 GPC4 COL5A3 FGG

3.30e-0417565428071719
Pubmed

Muscleblind-like 1 is required for normal heart valve development in vivo.

VCAN NCAN

3.56e-041565226472242
Pubmed

ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.

VCAN NCAN

3.56e-041565238871984
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

DIS3L2 OGFR CAPG UBA6

3.91e-0418365431932471
Pubmed

Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.

CCT5 GNB1

4.59e-041765219376773
Pubmed

Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.

GPC4 GPC6

5.16e-041865236057966
Pubmed

eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling.

VCAN NOS3

5.16e-041865238111957
Pubmed

Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.

VCAN GPC4

5.16e-041865212684764
Pubmed

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier.

NCAN NOS3

5.16e-041865218501628
Pubmed

Wilms Tumor Predisposition

DIS3L2 GPC4

5.16e-041865220301471
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

FBLN2 VCAN FGG

5.71e-048665328327460
Pubmed

Gene Expression by Mouse Inner Ear Hair Cells during Development.

CDH23 STRIP2

5.76e-041965225904789
Pubmed

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.

VCAN NCAN PKD1 COL5A3

6.56e-0421065416537572
Pubmed

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.

GPC4 GPC6

7.06e-042165226116392
Pubmed

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.

PKD1 LRP2

7.06e-042165227591083
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

DNAH3 DIS3L2 CCT5 OGFR GPC4 GNB1 GSN

7.42e-0480365736517590
Pubmed

Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics.

LRP2 FGG

7.76e-042265210438476
Pubmed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

FBLN2 VCAN COL5A3

8.10e-049765327559042
Pubmed

Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.

COL5A3 NR3C1

9.24e-042465236109497
Pubmed

Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes.

VCAN NCAN

9.24e-042465225344368
Pubmed

Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.

GPC4 GPC6

1.00e-032565226393505
Pubmed

Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development.

VCAN NOS3

1.00e-032565222536403
Pubmed

Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.

CHEK2 GGA1 STRIP2

1.17e-0311065337219487
Pubmed

Genetic link between renal birth defects and congenital heart disease.

PKD1 LRP2

1.26e-032865227002738
Pubmed

Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.

GPC4 GPC6

1.26e-032865219762422
Pubmed

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.

STRIP2 STRIP1

1.35e-032965221834987
Pubmed

Role of Elavl-like RNA-binding protein in retinal development and signal transduction.

GJA10 GNB1

1.54e-033165239307290
Pubmed

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

CCT5 KIAA0232

1.54e-033165228089446
Pubmed

Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

LRP2 GPC6

1.65e-033265225189868
Pubmed

Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry.

FGG GSN

1.65e-033265223750785
Pubmed

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

CCT5 GSN STRIP2 STRIP1

1.66e-0327065424366813
InteractionPPP2R2B interactions

FCGBP CCT5 CAPG CHEK2 FGG NR3C1 NOS3 GSN

1.15e-06248648int:PPP2R2B
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

VCAN NCAN

4.13e-054482574
GeneFamilyGlypicans

GPC4 GPC6

1.03e-046482572
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

VCAN NCAN PKD1

1.74e-04414831298
GeneFamilyGelsolin/villins

CAPG GSN

1.91e-048482950
GeneFamilyC-type lectin domain family

CLEC18A CLEC18B CLEC18C

2.62e-0447483494
GeneFamilyCadherin related

CDH23 CLSTN1

9.15e-041748224
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

STRIP2 STRIP1

1.27e-03204821371
GeneFamilyGap junction proteins

GJA9 GJA10

1.54e-0322482314
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

VCAN NCAN

1.00e-02574821179
GeneFamilyProteases, serine

TMPRSS15 TMPRSS11D

1.22e-0263482738
CoexpressionNABA_MATRISOME

CLEC18A TMPRSS15 FBLN2 CLEC18B MEGF8 VCAN NCAN GPC4 CLEC18C COL5A3 FGG GPC6

6.02e-0610086512MM17056
CoexpressionNABA_MATRISOME

CLEC18A TMPRSS15 FBLN2 CLEC18B MEGF8 VCAN NCAN GPC4 CLEC18C COL5A3 FGG GPC6

7.20e-0610266512M5889
CoexpressionAtlasMESO-30 amniotic fluid MSC_vs_MESO-30 blastocyst-Confounder_removed-fold2.0_adjp0.05

CLEC18A DIS3L2 CLEC18B RTL5 ANKRD37 CAPG PKD1 GPC4 LRP2 CLEC18C CDH23 PDCD2L CLSTN1 GGA1 STRIP2

2.60e-0612456315PCBC_ratio_MESO-30 amniotic fluid MSC_vs_MESO-30 blastocyst_cfr-2X-p05
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMVK PROM2 NBEAL2 IL17RC GSN TFR2

3.74e-0719265644cb225392c8d07150955ecf203fbdf6021c9790
ToppCellLA|World / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN LRP2 GPC6 GSN

3.86e-07193656d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN COL5A3 GPC6 GSN

4.10e-071956566a02ebbeb3199447ddce64d92d8809436e040eba
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

FBLN2 VCAN COL5A3 GPC6 GSN

4.85e-061696556373562ab3b1765060212a6a53d6543e7e942e80
ToppCell390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FCGBP GPC4 TEAD1 ACY1 GSN

5.44e-061736551f725ff16e28636b20ef26f3fa9be8b47c89378d
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

CAPN13 LYPD6B FCGBP ACY1 HNMT

5.59e-061746557d2f802f493f19a068e097b2909a9000e2160266
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN GPC6 GSN

6.42e-06179655dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN GPC6 GSN

6.77e-061816552b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN13 LYPD6B FCGBP PROM2 HNMT

6.96e-061826553f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 NCAN COL5A3 IL17RC TEAD1

7.14e-061836556f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

CAPN13 LYPD6B FCGBP PROM2 HNMT

7.14e-06183655940cbe298e9c53b5622af09264586ed823d3141f
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

LRRC66 FBLN2 MAMDC2 COL5A3 GPC6

7.33e-061846552b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN GPC6 GSN

7.93e-061876554ea486991f66c29728d127171a07b81404ec0b78
ToppCellDiffer-KC|World / shred by cell class for mouse tongue

PMVK CAPG TMPRSS11D IL17RC GSN

7.93e-0618765508f70e5103c6dd96f439f0cceda878963d26850d
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 MAMDC2 VCAN LRP2 COL5A3

7.93e-061876554e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 MAMDC2 VCAN LRP2 COL5A3

7.93e-06187655d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 MAMDC2 VCAN LRP2 COL5A3

7.93e-06187655827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell(2)_Fibroblasts-(20)_Fibro-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FBLN2 VCAN CAPG COL5A3 GSN

8.14e-06188655409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCellClub|World / shred by cell class for parenchyma

CAPN13 LYPD6B FCGBP PROM2 HNMT

8.57e-061906551974d559d7fee6cb68065b18af8bd38b64910622
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN2 VCAN COL5A3 GPC6 GSN

8.79e-061916554b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN2 VCAN COL5A3 GPC6 GSN

8.79e-0619165575d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GPC6 GSN

9.01e-06192655a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellRV-01._Fibroblast_I|RV / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN COL5A3 GSN

9.01e-06192655356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GPC6 GSN

9.01e-06192655eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAMDC2 VCAN COL5A3 GPC6 GSN

9.24e-06193655d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN COL5A3 GSN

9.24e-06193655dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GPC6 GSN

9.24e-06193655160691b671710be10220803d788c2c961c236af1
ToppCellfacs-Kidney-nan-18m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GPC6 GSN

9.48e-06194655bbc625b4cc53bb7d6254fde287258e51f9171572
ToppCellfacs-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GPC6 GSN

9.48e-06194655fcd5e9238d299c41f0bf9693b56cd8c900d2112b
ToppCellfacs-Kidney-nan-18m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GPC6 GSN

9.48e-061946556afc21c5fec30ab8e373e3e46ab7866204c805b6
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN GPC6 GSN

9.48e-06194655234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN GPC6 GSN

9.72e-06195655a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellEpithelial_cells-Club_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

CAPN13 FCGBP PROM2 HNMT GSN

9.72e-06195655b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMVK PROM2 IL17RC GSN TFR2

9.72e-06195655c54b19e31efe2c9ae690062569da7c0f1120a1d8
ToppCellfacs-Trachea|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 VCAN CAPG GPC6 GSN

9.96e-061966558209f2b0f7efebaaf81d642d18a1aee8a9a8dcf6
ToppCellfacs-Trachea|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN CAPG GPC6 GSN

9.96e-0619665534020d6553309daa269dff05de0a8567211ea4d2
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC-DC3|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

RTL5 VCAN CAPG RXFP1 HNMT

9.96e-06196655d4e5b55a32d9c04c6b2ca7806a0d96231918761f
ToppCellRA-02._Fibroblast_II|World / Chamber and Cluster_Paper

FBLN2 MAMDC2 VCAN GPC6 GSN

9.96e-06196655e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FCGBP ANKRD37 VCAN CAPG HNMT

1.05e-0519865506e13ba14bda79e01a757ceb9e88de133053df61
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CAPN13 LYPD6B FCGBP PROM2 TMPRSS11D

1.07e-051996553c3133d0aa65338a576634def13e7f0f5c573a10
ToppCell(2)_Fibroblasts-(24)_Fibro-5|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FBLN2 MAMDC2 VCAN CAPG GSN

1.07e-051996556c0354f57883330c685a8d9d5d3014ace7eca584
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 MAMDC2 VCAN GPC6 GSN

1.10e-05200655933b5b400e48a511ba0a056be1d33d3610b5f10d
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FCGBP CAPG GPC6 HNMT GSN

1.10e-05200655a2548b0c77ba1616638351b111cce2fe0cacaa95
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 MAMDC2 VCAN GPC6 GSN

1.10e-052006556f7f015b5fa1f52374f2c7d9ba339012395eda5f
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 MAMDC2 VCAN GPC6 GSN

1.10e-052006553a164e3971bcd62b148b813171c103adb81f972e
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FCGBP CAPG GPC6 HNMT GSN

1.10e-05200655e4a499b69554f78161c2c47199da77c201910e73
ToppCell5'-Adult-LargeIntestine-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 MAMDC2 VCAN GPC6 GSN

1.10e-052006555a87bb8eb1c6bd2fbc357e1528e15ba1c0051438
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-St18_(Lateral_CA3_Principal_cells)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CAPN13 CLEC18A FCGBP

2.95e-0541653083d2aab96ba9449797f955507c4a1be51ac5c8d
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CAPN13 LYPD6B FCGBP HNMT

7.22e-051526541b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Cst3_(Cst3)--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CIB3 PROM2 GJA10

8.83e-05596531b89466083bb454812e150137514300aa8228828
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Cst3_(Cst3)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CIB3 PROM2 GJA10

8.83e-0559653e81235f93aaf7f373d7cbd00882e32b73da29633
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Cst3_(Cst3)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CIB3 PROM2 GJA10

8.83e-05596534f0bfb48c0a98487f37da31e14e64282c70d5e66
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 RTL5 NOS3 STRIP1

9.46e-05163654bb09e6ca3406eee0593d9a312db7e05934309dd2
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_OR1J1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL5A3 RXFP1 GPC6 HNMT

9.92e-051656541f88f6939f88b80a0c98b4eef3684ba03c64ff7c
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4|TCGA-Lung / Sample_Type by Project: Shred V9

FBLN2 VCAN COL5A3 GPC6

1.06e-04168654aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCellSmart-seq2-blood_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

OGFR NBEAL2 VCAN EPB42

1.09e-041696540ee74cc97a2db9cc16dc73424f74747afe13af90
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHEK2 CARS1 COL5A3 ACY1

1.11e-041706548465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VCAN NCAN GPC4 COL5A3

1.16e-0417265455fba5ce0ead1114e1a76f67ad68432c6bac90e5
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMVK NBEAL2 TMPRSS11D TFR2

1.16e-041726546ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCellmild_COVID-19_(asymptomatic)-cDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

FBLN2 CIB3 CAPG GSN

1.19e-0417365471dc0051c87b84e3cf13cde8858166f2a474b5dc
ToppCellfacs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPG GPC4 LRP2 ACY1

1.24e-04175654076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCellfacs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPG GPC4 LRP2 ACY1

1.24e-04175654445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B FBLN2 NOS3 GSN

1.27e-041766541df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CAPN13 LYPD6B FCGBP PROM2

1.30e-04177654779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CAPN13 LYPD6B FCGBP PROM2

1.30e-041776540f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN13 CLEC18A LYPD6B IL17RC

1.33e-04178654445fb243d738a34794d66f34b92dde1f3ea6738e
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

CAPN13 LYPD6B FCGBP HNMT

1.36e-041796541fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCelldroplet-Bladder-nan-24m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 COL5A3 TRIM65 GSN

1.36e-04179654dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FCGBP CLEC18B CLSTN1 GSN

1.36e-04179654c833ded1f9e87be2ba2037820d92a389560b711c
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 VCAN COL5A3 GPC6

1.39e-0418065439ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCellmild_COVID-19_(asymptomatic)-cDC|World / disease group, cell group and cell class (v2)

FBLN2 CAPG ZMIZ1 GSN

1.39e-0418065468d1c867734fb2977b01ac686b20bf602f9a6b72
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAMDC2 VCAN GPC6 GSN

1.45e-041826543dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 MAMDC2 GPC6 GSN

1.48e-041836542beb5414958d38a5341870d55229f3b1707e76bf
ToppCellB_cells-ABCs|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

NBEAL2 CAPG ICA1L GSN

1.48e-04183654bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 NCAN TEAD1 NOS3

1.51e-04184654f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 NCAN TEAD1 NOS3

1.51e-041846548bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellfacs-Brain_Myeloid-Cortex|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FGG ZMIZ1 GSN

1.51e-0418465417f63dd671f9ff3dd2860d8de41b05c35c095950
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLEC18A CLEC18B CLEC18C GPC6

1.54e-041856548ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBLN2 VCAN COL5A3 GSN

1.54e-041856548f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|343B / Donor, Lineage, Cell class and subclass (all cells)

FCGBP CAPG HNMT GSN

1.54e-04185654d4ba36bdb8b7e3a62e827269484f89f790eaa5ef
ToppCellCOVID-19_Convalescent-CD8+_T_naive|COVID-19_Convalescent / Disease condition and Cell class

FCGBP CARS1 CDH23 ICA1L

1.54e-041856542f8277a0b58fb0c49fa76ff6dfa6da961da1f9f5
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLEC18A CLEC18B CLEC18C GPC6

1.54e-04185654b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAMDC2 VCAN COL5A3 GSN

1.60e-041876546f47a80e612b320f571210483e62ff5db2a8ea43
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 VCAN COL5A3 GPC6

1.64e-041886546c6486cae9a8f2f8200598cb4bfd3fd513eb28a3
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B FBLN2 NOS3 GSN

1.64e-04188654a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic|GI_large-bowel / Manually curated celltypes from each tissue

FCGBP MAMDC2 VCAN HNMT

1.64e-04188654d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBLN2 MAMDC2 COL5A3 GSN

1.64e-04188654fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes|GI_large-bowel / Manually curated celltypes from each tissue

FCGBP MAMDC2 VCAN HNMT

1.64e-041886540bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBLN2 GPC4 COL5A3 GPC6

1.64e-04188654de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|343B / Donor, Lineage, Cell class and subclass (all cells)

CAPN13 FCGBP PROM2 HNMT

1.67e-04189654b06471b1bebb990d5146bddfb8002401c6b099a0
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GSN

1.67e-041896540a8b827bba1efd885ad6c06929251c741dc3a541
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|343B / Donor, Lineage, Cell class and subclass (all cells)

CAPN13 FCGBP PROM2 HNMT

1.67e-04189654a8246acf31f02c85421268245afb651aa8788f14
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VCAN GPC4 LRP2 GPC6

1.67e-0418965428b502611829e4a24caff2562545c7db97686099
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GSN

1.71e-04190654bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GSN

1.71e-04190654e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VCAN COL5A3 GPC6 GSN

1.71e-04190654947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 VCAN COL5A3 GSN

1.71e-04190654ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCelldroplet-Heart-nan-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VCAN COL5A3 GPC6 GSN

1.71e-0419065496a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell(7)_Epithelial-G_(Club-Clara_cells)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CAPN13 LYPD6B FCGBP PROM2

1.71e-04190654593fd1451038b155826a48de4caa38f44406d0b9
ToppCelldroplet-Mammary_Gland-nan-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 CAPG COL5A3 GSN

1.74e-041916548022059e434fd411dc539819f969bd4f94861281
DrugPractolol [6673-35-4]; Down 200; 15uM; PC3; HT_HG-U133A

ZNF473 OGFR NBEAL2 GPC4 IL17RC NR3C1 HNMT

1.43e-061996474603_DN
DrugNVP-AAD777

GPC4 GPC6 NOS3

9.41e-0615643CID006918569
Drugclozapine; Down 200; 10uM; MCF7; HT_HG-U133A

DNAH3 ZNF473 KIAA0232 CAPG IL17RC GGA1

1.87e-051966466988_DN
DrugDoxepin hydrochloride [1229-29-4]; Down 200; 12.6uM; HL60; HT_HG-U133A

DNAH3 KIDINS220 LRP2 PEX5 GGA1 TFR2

1.92e-051976462384_DN
DrugTinidazole [19387-91-8]; Up 200; 16.2uM; HL60; HT_HG-U133A

KIDINS220 OGFR VCAN NCAN HNMT TFR2

1.92e-051976462568_UP
DrugBisoprolol fumarate; Down 200; 9uM; MCF7; HT_HG-U133A

OGFR NBEAL2 GPC4 NR3C1 HNMT GGA1

2.03e-051996462642_DN
Diseaselung disease (biomarker_via_orthology)

NR3C1 NOS3 GSN

5.78e-0535633DOID:850 (biomarker_via_orthology)
Diseasepulse pressure measurement, anxiety

GJA9 GJA10

9.36e-057632EFO_0005230, EFO_0005763
Diseaseend stage renal disease (biomarker_via_orthology)

LRP2 NR3C1 NOS3

1.41e-0447633DOID:783 (biomarker_via_orthology)
Diseaseintracranial aneurysm (is_implicated_in)

VCAN PKD1

2.92e-0412632DOID:10941 (is_implicated_in)
Diseasepulmonary embolism (biomarker_via_orthology)

FGG NOS3

2.92e-0412632DOID:9477 (biomarker_via_orthology)
Diseasebody surface area

LRRC66 FBLN2 DIS3L2 ZMIZ1 TEAD1 NR3C1 MED13L

4.34e-04643637EFO_0022196
Diseaseoptic disc size measurement

VCAN CHEK2 LRP2 STRIP1

9.78e-04205634EFO_0004832
Diseasewhite matter integrity, age at assessment

VCAN ICA1L

1.41e-0326632EFO_0004641, EFO_0008007
Diseaseobstructive sleep apnea (is_marker_for)

NR3C1 NOS3

1.76e-0329632DOID:0050848 (is_marker_for)
DiseaseProstatic Neoplasms

CHEK2 LRP2 COL5A3 IL17RC NR3C1 NOS3

2.00e-03616636C0033578
DiseaseMalignant neoplasm of prostate

CHEK2 LRP2 COL5A3 IL17RC NR3C1 NOS3

2.00e-03616636C0376358
Diseasecuneus cortex volume measurement

GJA9 GJA10

2.00e-0331632EFO_0010301

Protein segments in the cluster

PeptideGeneStartEntry
ADCIQAESWDFGQFE

EPB42

171

P16452
DGFEQCDAGWLADQT

VCAN

191

P13611
GELQAAWRNGFDQCD

VCAN

281

P13611
AEDVWDDEQSAFACN

GJA10

41

Q969M2
SRFDIQQGGAADCWF

CAPN13

81

Q6MZZ7
VGACWQEFSGVENDN

CLSTN1

501

O94985
LWALQDGFANLECVN

CHEK2

96

O96017
VDWKEDCNFALGQLA

DIS3L2

306

Q8IYB7
WLNCTDNDVGLNAEL

CDH23

1016

Q9H251
DLCNKNGQTAEDLAW

ANKRD37

91

Q7Z713
DFEENHLCGFVNRWN

MAMDC2

171

Q7Z304
GANCNLEDLDNWTAL

KIDINS220

61

Q9ULH0
ADNNDYWTECFNALE

MED13L

1266

Q71F56
LNLTNDGNLSNDWDF

MAGEB1

181

P43366
GCLANQGDLDFEWNN

GPC4

276

O75487
NCNFEDGFCFWVQDL

TMPRSS15

346

P98073
DGFCFWVQDLNDDNE

TMPRSS15

351

P98073
CAAGQQWAIDNDECL

FBLN2

446

P98095
NGDLLWDFLTETCNF

HNMT

236

P50135
LQDLGNLAQFWECCS

KIAA0232

581

Q92628
AQKQGNSLAAEDWCE

PDCD2L

111

Q9BRP1
ENWAQEFLAAGDAVD

PEX5

116

P50542
NQREVFWAGNCSEAA

MEGF8

1981

Q7Z7M0
DWASINGFCEQLNED

GGA1

26

Q9UJY5
SENWNRCQGSGDDNL

NR3C1

361

P04150
RWQCDGQNDCGDNSD

LRP2

3736

P98164
LADNNWQCDDSVAVF

LRRC66

251

Q68CR7
DELCGQEEAFRGWAQ

NOS3

686

P29474
WDNDNDKFEGNCAEQ

FGG

341

P02679
GCLANQADLDTEWNL

GPC6

276

Q9Y625
NNFDWLENCLGHVED

GPN3

86

Q9UHW5
LAQAGAWACFDEFNR

DNAH3

1471

Q8TD57
LAGYDDFNCNVWDAL

GNB1

286

P62873
AEDVWNDEQSGFICN

GJA9

41

P57773
ACGNFDGDQTNDWHD

FCGBP

5371

Q9Y6R7
WQDVEDFARAEGCDN

HBP1

231

O60381
NWDSFNTGDCFILDL

CAPG

156

P40121
SWESFNNGDCFILDL

GSN

206

P06396
GAFNNWVSQEESELC

ICA1L

411

Q8NDH6
CQNAAAWLDEATGDY

COL5A3

1651

P25940
QSGQCLQLWDDDLGA

IL17RC

511

Q8NAC3
QAQEQCQAWAGAALA

PKD1

431

P98161
NGCFIEDILQNWTDN

OGFR

106

Q9NZT2
DAFQFLAQFLSWDDC

RTL5

256

Q5HYW3
NELAQSEAYFENDCW

CARS1

376

P49589
ESLEAGDNSQFCWRN

STRIP2

646

Q9ULQ0
QDFLCAEGHGNQELW

NBEAL2

1531

Q6ZNJ1
QAAFEDGFDNCDAGW

NCAN

196

O14594
SLEAGDSNQFCWRNL

STRIP1

651

Q5VSL9
GANLAICQWGFDDEA

CCT5

296

P48643
CGLDNFGDFDWVIEN

PMVK

156

Q15126
FEEQLQSWCQAAGEG

ACY1

286

Q03154
DFNNDDYICAWDLEQ

CIB3

116

Q96Q77
GNCVELQASAAFNWN

CLEC18A

406

A5D8T8
NCVELQASAAFNWND

CLEC18B

416

Q6UXF7
GNCVELQASAAFNWN

CLEC18C

406

Q8NCF0
TDQAAANWLINECGA

TMPRSS11D

161

O60235
CQAWDLGTNFFLSED

UBA6

96

A0AVT1
NGWANELLHEFECNV

UHRF1BP1L

386

A0JNW5
NFCKNGIWENNSDLG

ZFP28

251

Q8NHY6
VCQSWENGELFEFAD

PROM2

506

Q8N271
QADEDNCGDNNGWSL

RXFP1

56

Q9HBX9
WADLNCNIQDDAGAF

TEAD1

291

P28347
CVQEDSLQAWHNGEA

TRIM65

426

Q6PJ69
AANALSGDVWNIDNN

TFR2

786

Q9UP52
ANFHNAATELLDWCG

ZMIZ1

26

Q9ULJ6
EQGDTFWDTALDNCQ

ZNF473

26

Q8WTR7
ENAGDNYNCNRWAED

LYPD6B

66

Q8NI32