Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of chondrocyte differentiation	ADAMTS12 EFEMP1 ADAMTS7 LTBP3	3.44e-06	27	80	4	GO:0032331
GeneOntologyBiologicalProcess	embryonic hemopoiesis	HSCB FLT3LG KMT2A ZFPM1	6.95e-06	32	80	4	GO:0035162
GeneOntologyBiologicalProcess	negative regulation of cartilage development	ADAMTS12 EFEMP1 ADAMTS7 LTBP3	1.12e-05	36	80	4	GO:0061037
GeneOntologyBiologicalProcess	positive regulation of myoblast fusion	FLT3LG NFATC2 ADGRB1	5.21e-05	19	80	3	GO:1901741
GeneOntologyBiologicalProcess	negative regulation of developmental process	ADAMTS12 FBN1 EFEMP1 NF1 NFATC2 ADAMTS7 ING1 ADAMTS9 ADGRB1 SAV1 LRP4 LTBP3 ZFPM1 EZH2 LDLR	6.11e-05	1220	80	15	GO:0051093
GeneOntologyBiologicalProcess	regulation of chondrocyte differentiation	ADAMTS12 EFEMP1 ADAMTS7 LTBP3	8.12e-05	59	80	4	GO:0032330
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	8.87e-05	4	80	2	GO:0035583
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR4 UBR3	8.87e-05	4	80	2	GO:0071596
GeneOntologyBiologicalProcess	regulation of myoblast fusion	FLT3LG NFATC2 ADGRB1	1.22e-04	25	80	3	GO:1901739
GeneOntologyBiologicalProcess	positive regulation of syncytium formation by plasma membrane fusion	FLT3LG NFATC2 ADGRB1	1.54e-04	27	80	3	GO:0060143
GeneOntologyBiologicalProcess	negative regulation of multicellular organismal process	ADAMTS12 FBN1 EFEMP1 NF1 ADAMTS7 ING1 ADAMTS9 ADGRB1 SAV1 LRP4 LTBP3 ZFPM1 EZH2 LDLR TRIM5 SVEP1	1.62e-04	1488	80	16	GO:0051241
GeneOntologyBiologicalProcess	collagen fibril organization	ADAMTS12 ADAMTS19 NF1 ADAMTS7	2.18e-04	76	80	4	GO:0030199
GeneOntologyBiologicalProcess	regulation of cartilage development	ADAMTS12 EFEMP1 ADAMTS7 LTBP3	2.78e-04	81	80	4	GO:0061035
GeneOntologyBiologicalProcess	regulation of syncytium formation by plasma membrane fusion	FLT3LG NFATC2 ADGRB1	3.66e-04	36	80	3	GO:0060142
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	4.10e-04	8	80	2	GO:0071694
GeneOntologyBiologicalProcess	tricuspid valve morphogenesis	ADAMTS19 ZFPM1	4.10e-04	8	80	2	GO:0003186
GeneOntologyBiologicalProcess	amyloid-beta clearance by cellular catabolic process	LRP4 LDLR	4.10e-04	8	80	2	GO:0150094
GeneOntologyBiologicalProcess	primitive erythrocyte differentiation	HSCB ZFPM1	4.10e-04	8	80	2	GO:0060319
GeneOntologyBiologicalProcess	myotube differentiation	FLT3LG NFATC2 PIEZO1 ADGRB1 PLD3	4.44e-04	164	80	5	GO:0014902
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS12 ADAMTS19 FBN1 FCGBP FBN2 EFEMP1 HMCN1 ADAMTS7 ADAMTS9 LTBP3 PKHD1L1 SVEP1	8.31e-06	658	81	12	GO:0030312
GeneOntologyCellularComponent	extracellular matrix	ADAMTS12 ADAMTS19 FBN1 FCGBP FBN2 EFEMP1 HMCN1 ADAMTS7 ADAMTS9 LTBP3 SVEP1	4.41e-05	656	81	11	GO:0031012
HumanPheno	Fifth metacarpal with ulnar notch	FBN1 LTBP3	3.58e-05	2	31	2	HP:0005900
HumanPheno	Gastric diverticulum	EFEMP1 RNF43	3.58e-05	2	31	2	HP:0100808
Domain	EGF_Ca-bd_CS	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	4.04e-10	97	82	9	IPR018097
Domain	EGF_CA	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	4.86e-10	99	82	9	PS01187
Domain	ASX_HYDROXYL	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	5.32e-10	100	82	9	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	8.99e-10	106	82	9	IPR000152
Domain	cEGF	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3	1.28e-09	26	82	6	IPR026823
Domain	cEGF	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3	1.28e-09	26	82	6	PF12662
Domain	EGF_CA	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	3.15e-09	122	82	9	SM00179
Domain	EGF-like_Ca-bd_dom	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	3.64e-09	124	82	9	IPR001881
Domain	EGF_CA	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1	3.92e-09	86	82	8	PF07645
Domain	Growth_fac_rcpt_	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	2.73e-08	156	82	9	IPR009030
Domain	EGF	FBN1 FCGBP FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	7.96e-08	235	82	10	SM00181
Domain	EGF-like_dom	FBN1 FCGBP FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	1.37e-07	249	82	10	IPR000742
Domain	EGF_1	FBN1 FBN2 EFEMP1 HMCN1 NTN5 LRP4 LTBP3 LDLR SVEP1 CRB1	1.70e-07	255	82	10	PS00022
Domain	EGF_2	FBN1 FBN2 EFEMP1 HMCN1 NTN5 LRP4 LTBP3 LDLR SVEP1 CRB1	2.43e-07	265	82	10	PS01186
Domain	TSP_1	ADAMTS12 ADAMTS19 HMCN1 ADAMTS7 ADAMTS9 ADGRB1	3.31e-07	63	82	6	PF00090
Domain	TSP1	ADAMTS12 ADAMTS19 HMCN1 ADAMTS7 ADAMTS9 ADGRB1	4.00e-07	65	82	6	SM00209
Domain	TSP1_rpt	ADAMTS12 ADAMTS19 HMCN1 ADAMTS7 ADAMTS9 ADGRB1	4.00e-07	65	82	6	IPR000884
Domain	TSP1	ADAMTS12 ADAMTS19 HMCN1 ADAMTS7 ADAMTS9 ADGRB1	4.00e-07	65	82	6	PS50092
Domain	EGF_3	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	8.95e-07	235	82	9	PS50026
Domain	EGF-like_CS	FBN1 FBN2 EFEMP1 HMCN1 LRP4 LTBP3 LDLR SVEP1 CRB1	2.13e-06	261	82	9	IPR013032
Domain	TB	FBN1 FBN2 LTBP3	2.82e-06	7	82	3	PF00683
Domain	ADAM_spacer1	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.87e-06	23	82	4	IPR010294
Domain	ADAM_spacer1	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.87e-06	23	82	4	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	3.43e-06	24	82	4	IPR013273
Domain	-	FBN1 FBN2 LTBP3	4.50e-06	8	82	3	3.90.290.10
Domain	hEGF	FBN2 LTBP3 SVEP1 CRB1	6.52e-06	28	82	4	PF12661
Domain	TB	FBN1 FBN2 LTBP3	6.72e-06	9	82	3	PS51364
Domain	TB_dom	FBN1 FBN2 LTBP3	6.72e-06	9	82	3	IPR017878
Domain	Peptidase_M12B_N	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.53e-05	39	82	4	IPR002870
Domain	Pep_M12B_propep	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.53e-05	39	82	4	PF01562
Domain	DISINTEGRIN_1	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.80e-05	40	82	4	PS00427
Domain	Reprolysin	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.80e-05	40	82	4	PF01421
Domain	ADAM_MEPRO	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.80e-05	40	82	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.80e-05	40	82	4	PS50214
Domain	Peptidase_M12B	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	2.80e-05	40	82	4	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	3.09e-05	41	82	4	PS00546
Domain	Disintegrin_dom	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	3.09e-05	41	82	4	IPR001762
Domain	Znf_RING/FYVE/PHD	KMT2D PHF20L1 ING1 CHFR KMT2A UBR3 RNF17 RNF43 TRIM59 TRIM5	3.21e-05	459	82	10	IPR013083
Domain	Pept_M10_metallopeptidase	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	3.74e-05	43	82	4	IPR001818
Domain	FBN	FBN1 FBN2	5.70e-05	3	82	2	IPR011398
Domain	PLAC	ADAMTS12 ADAMTS19 ADAMTS7	7.51e-05	19	82	3	PS50900
Domain	PLAC	ADAMTS12 ADAMTS19 ADAMTS7	7.51e-05	19	82	3	IPR010909
Domain	-	KMT2D PHF20L1 ING1 CHFR KMT2A UBR3 RNF43 TRIM59 TRIM5	1.54e-04	449	82	9	3.30.40.10
Domain	FYrich_C	KMT2D KMT2A	1.89e-04	5	82	2	IPR003889
Domain	FYrich_N	KMT2D KMT2A	1.89e-04	5	82	2	IPR003888
Domain	FYRC	KMT2D KMT2A	1.89e-04	5	82	2	SM00542
Domain	FYRN	KMT2D KMT2A	1.89e-04	5	82	2	SM00541
Domain	FYRN	KMT2D KMT2A	1.89e-04	5	82	2	PF05964
Domain	FYRC	KMT2D KMT2A	1.89e-04	5	82	2	PF05965
Domain	FYRC	KMT2D KMT2A	1.89e-04	5	82	2	PS51543
Domain	FYRN	KMT2D KMT2A	1.89e-04	5	82	2	PS51542
Domain	ZF_RING_1	KMT2D CHFR UBR3 RNF17 RNF43 TRIM59 TRIM5	2.91e-04	291	82	7	PS00518
Domain	TIG	NFATC2 CAMTA1 PKHD1L1	3.36e-04	31	82	3	PF01833
Domain	ZF_RING_2	KMT2D CHFR UBR3 RNF17 RNF43 TRIM59 TRIM5	3.36e-04	298	82	7	PS50089
Domain	IPT	NFATC2 CAMTA1 PKHD1L1	3.69e-04	32	82	3	IPR002909
Domain	ZF_UBR	UBR4 UBR3	3.94e-04	7	82	2	PS51157
Domain	zf-UBR	UBR4 UBR3	3.94e-04	7	82	2	PF02207
Domain	Znf_UBR	UBR4 UBR3	3.94e-04	7	82	2	IPR003126
Domain	ZnF_UBR1	UBR4 UBR3	3.94e-04	7	82	2	SM00396
Domain	MetalloPept_cat_dom	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	4.44e-04	81	82	4	IPR024079
Domain	-	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	4.44e-04	81	82	4	3.40.390.10
Domain	Znf_RING	KMT2D CHFR UBR3 RNF17 RNF43 TRIM59 TRIM5	5.74e-04	326	82	7	IPR001841
Domain	SET	KMT2D KMT2A EZH2	7.71e-04	41	82	3	PF00856
Domain	ZF_PHD_1	KMT2D PHF20L1 ING1 KMT2A	8.44e-04	96	82	4	PS01359
Domain	ZINC_PROTEASE	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	9.11e-04	98	82	4	PS00142
Domain	-	HMCN1 SVEP1	1.02e-03	11	82	2	2.40.155.10
Domain	GFP-like	HMCN1 SVEP1	1.02e-03	11	82	2	IPR023413
Domain	SET	KMT2D KMT2A EZH2	1.08e-03	46	82	3	SM00317
Domain	Ig_E-set	NFATC2 ARRDC4 CAMTA1 PKHD1L1	1.14e-03	104	82	4	IPR014756
Domain	SET_dom	KMT2D KMT2A EZH2	1.38e-03	50	82	3	IPR001214
Domain	SET	KMT2D KMT2A EZH2	1.38e-03	50	82	3	PS50280
Domain	Ldl_recept_b	LRP4 LDLR	1.67e-03	14	82	2	PF00058
Domain	LDLRB	LRP4 LDLR	1.67e-03	14	82	2	PS51120
Domain	LY	LRP4 LDLR	1.93e-03	15	82	2	SM00135
Domain	LDLR_classB_rpt	LRP4 LDLR	1.93e-03	15	82	2	IPR000033
Domain	Post-SET_dom	KMT2D KMT2A	2.20e-03	16	82	2	IPR003616
Domain	PostSET	KMT2D KMT2A	2.20e-03	16	82	2	SM00508
Domain	POST_SET	KMT2D KMT2A	2.20e-03	16	82	2	PS50868
Domain	RING	KMT2D CHFR RNF17 RNF43 TRIM59 TRIM5	2.24e-03	305	82	6	SM00184
Domain	EGF	HMCN1 LRP4 SVEP1 CRB1	2.30e-03	126	82	4	PF00008
Domain	zf-C3HC4	CHFR UBR3 RNF43 TRIM59 TRIM5	3.00e-03	223	82	5	PF00097
Domain	CONNEXINS_1	GJB4 GJC1	3.10e-03	19	82	2	PS00407
Domain	CONNEXINS_2	GJB4 GJC1	3.44e-03	20	82	2	PS00408
Domain	Connexin	GJB4 GJC1	3.44e-03	20	82	2	IPR000500
Domain	Connexin_CCC	GJB4 GJC1	3.44e-03	20	82	2	IPR019570
Domain	Connexin_N	GJB4 GJC1	3.44e-03	20	82	2	IPR013092
Domain	Connexin	GJB4 GJC1	3.44e-03	20	82	2	PF00029
Domain	Connexin_CCC	GJB4 GJC1	3.44e-03	20	82	2	SM01089
Domain	Connexin_CS	GJB4 GJC1	3.44e-03	20	82	2	IPR017990
Domain	CNX	GJB4 GJC1	3.44e-03	20	82	2	SM00037
Domain	Znf_FYVE_PHD	KMT2D PHF20L1 ING1 KMT2A	4.01e-03	147	82	4	IPR011011
Domain	EPHD	KMT2D KMT2A	4.15e-03	22	82	2	PS51805
Domain	PHD	KMT2D ING1 KMT2A	4.39e-03	75	82	3	PF00628
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2 EFEMP1 LTBP3	9.19e-06	37	51	4	M27134
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	1.14e-05	39	51	4	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	1.14e-05	39	51	4	MM15165
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2 EFEMP1 LTBP3	1.85e-05	44	51	4	M26969
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	1.04e-04	68	51	4	M27303
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2 LTBP3	2.05e-04	32	51	3	MM14854
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KMT2D PHF20L1 KMT2A	3.44e-04	38	51	3	MM17073
Pathway	KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA	FBN1 LTBP3	3.54e-04	8	51	2	M47850
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2 LTBP3	3.72e-04	39	51	3	MM14601
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KMT2D PHF20L1 KMT2A	4.64e-04	42	51	3	M48018
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	KMT2D KMT2A ZFPM1	5.32e-04	44	51	3	MM15527
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2D KMT2A EZH2	6.07e-04	46	51	3	MM14933
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	6.39e-04	109	51	4	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	6.84e-04	111	51	4	M27416
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	FBN1 FBN2 EFEMP1 ADAMTS9 LRP4 LTBP3	7.11e-04	300	51	6	M610
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	FZD3 LRP4	1.14e-03	14	51	2	M47834
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS12 ADAMTS19 HMCN1 ADAMTS7 ADAMTS9 ADGRB1	2.52e-08	75	82	6	20637190
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2 EFEMP1	5.04e-08	4	82	3	25406291
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TYK2 KMT2D ZNF628 ADAMTS7 PIEZO1 ZNF408 UBR4 TMEM268 LRP4 LTBP3 ZFPM1 LDLR RNF43 TOP3A	2.89e-07	1105	82	14	35748872
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 FBN2 LTBP3 CRYBG3 CRB1	7.42e-07	71	82	5	33541421
Pubmed	A census of human transcription factors: function, expression and evolution.	TBX22 BCL6B GSX1 KMT2D ZBTB17 NFATC2 KMT2A PLAGL2 ZFPM1 CAMTA1 EZH2 LHX6	1.45e-06	908	82	12	19274049
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS12 ADAMTS7 ADAMTS9	1.50e-06	10	82	3	11167130
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS12 ADAMTS7 ADAMTS9	2.74e-06	12	82	3	25770910
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	5.49e-06	2	82	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	5.49e-06	2	82	2	21851253
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	5.49e-06	2	82	2	30044367
Pubmed	Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.	FBN1 LTBP3	5.49e-06	2	82	2	26494287
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	5.49e-06	2	82	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	5.49e-06	2	82	2	15131124
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	5.49e-06	2	82	2	20404337
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	5.49e-06	2	82	2	8791520
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	5.49e-06	2	82	2	8307578
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	5.49e-06	2	82	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	5.49e-06	2	82	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	5.49e-06	2	82	2	18006876
Pubmed	The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.	ADAMTS12 ADAMTS7	5.49e-06	2	82	2	19098927
Pubmed	Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.	EZH2 TOP3A	5.49e-06	2	82	2	35032074
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	5.49e-06	2	82	2	24833718
Pubmed	Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.	KMT2D KMT2A	5.49e-06	2	82	2	26711341
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	5.49e-06	2	82	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	5.49e-06	2	82	2	20529844
Pubmed	Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.	KMT2D KMT2A	5.49e-06	2	82	2	24423662
Pubmed	MLL1:EZH2 Ratio in Uterine Secretions and Endometrial Receptivity in Patients with Endometriosis.	KMT2A EZH2	5.49e-06	2	82	2	36094360
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	5.49e-06	2	82	2	23133647
Pubmed	Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome.	FBN1 LTBP3	5.49e-06	2	82	2	30306291
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	5.49e-06	2	82	2	1852206
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	5.49e-06	2	82	2	12429739
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	5.49e-06	2	82	2	12524050
Pubmed	LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections.	FBN1 LTBP3	5.49e-06	2	82	2	29625025
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	5.49e-06	2	82	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	5.49e-06	2	82	2	35419902
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	5.49e-06	2	82	2	10504303
Pubmed	Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm.	FBN1 EZH2	5.49e-06	2	82	2	29515022
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	5.49e-06	2	82	2	25524144
Pubmed	An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells.	NFATC2 EZH2	5.49e-06	2	82	2	30710146
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	5.49e-06	2	82	2	16407178
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	5.49e-06	2	82	2	10359653
Pubmed	Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation.	ADAMTS12 ADAMTS7	5.49e-06	2	82	2	22247065
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	ADAMTS19 FBN1 FBN2	1.00e-05	18	82	3	35503090
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	1.64e-05	3	82	2	10825173
Pubmed	Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas.	NF1 EZH2	1.64e-05	3	82	2	31431463
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	1.64e-05	3	82	2	30201140
Pubmed	Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.	KMT2D KMT2A	1.64e-05	3	82	2	26902498
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2D KMT2A	1.64e-05	3	82	2	23932714
Pubmed	PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis.	HSCB ZFPM1	1.64e-05	3	82	2	38757931
Pubmed	Geleophysic Dysplasia	FBN1 LTBP3	1.64e-05	3	82	2	20301776
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	1.64e-05	3	82	2	20855508
Pubmed	Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.	ADAMTS7 LDLR	1.64e-05	3	82	2	25712206
Pubmed	Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.	FLT3LG LDLR	1.64e-05	3	82	2	24551105
Pubmed	EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.	ADGRB1 EZH2	1.64e-05	3	82	2	31582835
Pubmed	MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.	KMT2D KMT2A	1.64e-05	3	82	2	23192982
Pubmed	Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.	KMT2A EZH2	1.64e-05	3	82	2	26431491
Pubmed	LncRNA embryonic stem cells expressed 1 (Lncenc1) is identified as a novel regulator in neuropathic pain by interacting with EZH2 and downregulating the expression of Bai1 in mouse microglia.	ADGRB1 EZH2	1.64e-05	3	82	2	33340495
Pubmed	Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.	KMT2D KMT2A	1.64e-05	3	82	2	30315824
Pubmed	The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.	KMT2A EZH2	3.28e-05	4	82	2	29754954
Pubmed	Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.	KMT2D KMT2A	3.28e-05	4	82	2	22863532
Pubmed	An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.	NF1 EZH2	3.28e-05	4	82	2	20154697
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	3.28e-05	4	82	2	20729550
Pubmed	Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons.	NF1 LHX6	3.28e-05	4	82	2	32123116
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	3.28e-05	4	82	2	25034023
Pubmed	KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.	KMT2D KMT2A	3.28e-05	4	82	2	37722486
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	3.28e-05	4	82	2	12429738
Pubmed	Polycomb repressive complex 2 is required for MLL-AF9 leukemia.	KMT2A EZH2	3.28e-05	4	82	2	22396593
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	3.28e-05	4	82	2	16835936
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2D KMT2A	3.28e-05	4	82	2	23129768
Pubmed	Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.	UBR4 EZH2	3.28e-05	4	82	2	34564701
Pubmed	Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.	ADAMTS12 ADAMTS7	3.28e-05	4	82	2	18485748
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2D KMT2A	3.28e-05	4	82	2	24081332
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	5.47e-05	5	82	2	26601954
Pubmed	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.	KMT2D KMT2A	5.47e-05	5	82	2	28609655
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	5.47e-05	5	82	2	23493297
Pubmed	Evolving Catalytic Properties of the MLL Family SET Domain.	KMT2D KMT2A	5.47e-05	5	82	2	26320581
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	5.47e-05	5	82	2	12590922
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	5.47e-05	5	82	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	5.47e-05	5	82	2	34411563
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TYK2 FBN2 ATXN7L2 TRIP6 ARRDC4 LRP4 CRYBG3 LDLR RNF43 C2CD5 WDTC1	6.17e-05	1116	82	11	31753913
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	KMT2D FBN1 FBN2 TRIP6 LDLR	7.70e-05	184	82	5	32908313
Pubmed	GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.	KMT2D KMT2A	8.19e-05	6	82	2	34933446
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2D KMT2A	8.19e-05	6	82	2	16199523
Pubmed	PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes.	PHF20L1 KMT2A	8.19e-05	6	82	2	30089852
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	8.19e-05	6	82	2	7873879
Pubmed	Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.	KMT2D KMT2A	8.19e-05	6	82	2	24176642
Pubmed	Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.	KMT2D KMT2A	1.14e-04	7	82	2	19219072
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2D KMT2A	1.14e-04	7	82	2	36598580
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	1.14e-04	7	82	2	11470817
Pubmed	Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.	KMT2A EZH2	1.14e-04	7	82	2	21135039
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2D ING1 ANGEL2 KMT2A EZH2 UNC79 GTF3C5	1.23e-04	469	82	7	27634302
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	1.52e-04	8	82	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	1.52e-04	8	82	2	31201465
Pubmed	Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.	NFATC2 PIEZO1	1.52e-04	8	82	2	30482854
Pubmed	MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells.	NFATC2 CAMTA1	1.52e-04	8	82	2	23853098
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2D KMT2A	1.52e-04	8	82	2	22266653
Pubmed	Divergent hTAFII31-binding motifs hidden in activation domains.	NFATC2 KMT2A	1.52e-04	8	82	2	10821850
Pubmed	The mutational landscape of lethal castration-resistant prostate cancer.	KMT2D KMT2A	1.52e-04	8	82	2	22722839
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2D KMT2A	1.52e-04	8	82	2	23130995
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	1.52e-04	8	82	2	18339631
Interaction	NTN5 interactions	FBN1 FBN2 NTN5 LRP4 LDLR	3.70e-08	24	81	5	int:NTN5
Interaction	ZNF408 interactions	FBN1 FBN2 EFEMP1 ZNF764 ZNF408 LRP4 LDLR	1.92e-06	145	81	7	int:ZNF408
Interaction	FBN2 interactions	FBN1 FBN2 ZNF408 NTN5 SVEP1	6.33e-06	65	81	5	int:FBN2
Interaction	LTBP1 interactions	FBN1 FBN2 EFEMP1 ZNF408 NTN5	3.46e-05	92	81	5	int:LTBP1
Cytoband	1p36.13	ZBTB17 SPATA21 UBR4	1.42e-04	56	82	3	1p36.13
Cytoband	11p11.2	ZNF408 LRP4 OR4X2	4.55e-04	83	82	3	11p11.2
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS19 ADAMTS7 ADAMTS9	4.99e-07	19	63	4	50
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D KMT2A EZH2	2.23e-04	34	63	3	487
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR4 UBR3	2.48e-04	7	63	2	785
GeneFamily	PHD finger proteins	KMT2D PHF20L1 ING1 KMT2A	2.73e-04	90	63	4	88
GeneFamily	Fibulins	EFEMP1 HMCN1	3.30e-04	8	63	2	556
GeneFamily	Low density lipoprotein receptors	LRP4 LDLR	9.09e-04	13	63	2	634
GeneFamily	Gap junction proteins	GJB4 GJC1	2.64e-03	22	63	2	314
GeneFamily	Ring finger proteins	CHFR RNF17 RNF43 TRIM59 TRIM5	2.69e-03	275	63	5	58
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BCL6B ZBTB17 ZNF628 ZNF425 ZNF764 ZNF408 PLAGL2 ZFPM1	3.35e-03	718	63	8	28
GeneFamily	Tudor domain containing	PHF20L1 RNF17	7.36e-03	37	63	2	780
Coexpression	NABA_ECM_GLYCOPROTEINS	FBN1 FBN2 EFEMP1 HMCN1 NTN5 LTBP3 SVEP1	2.16e-06	191	81	7	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	FBN1 FBN2 EFEMP1 HMCN1 NTN5 LTBP3 SVEP1	2.56e-06	196	81	7	M3008
Coexpression	NABA_CORE_MATRISOME	FBN1 FBN2 EFEMP1 HMCN1 NTN5 LTBP3 SVEP1	2.07e-05	270	81	7	MM17057
Coexpression	NABA_CORE_MATRISOME	FBN1 FBN2 EFEMP1 HMCN1 NTN5 LTBP3 SVEP1	2.32e-05	275	81	7	M5884
Coexpression	HE_LIM_SUN_FETAL_LUNG_C3_INTERMEDIATE_LYMPHATIC_ENDO_CELL	ADAMTS12 FBN1 EFEMP1 NFATC2 TRIP6 ADAMTS9 ARRDC4 PKHD1L1	3.46e-05	402	81	8	M45754
Coexpression	GSE4984_LPS_VS_VEHICLE_CTRL_TREATED_DC_DN	NF1 NFATC2 PIEZO1 SAV1 CAMTA1 HNRNPLL	3.49e-05	198	81	6	M6511
Coexpression	NABA_MATRISOME	ADAMTS12 ADAMTS19 FLT3LG FBN1 FBN2 EFEMP1 HMCN1 ADAMTS7 ADAMTS9 NTN5 LTBP3 SVEP1	6.01e-05	1008	81	12	MM17056
Coexpression	NABA_MATRISOME	ADAMTS12 ADAMTS19 FLT3LG FBN1 FBN2 EFEMP1 HMCN1 ADAMTS7 ADAMTS9 NTN5 LTBP3 SVEP1	7.12e-05	1026	81	12	M5889
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS19 FBN2 HMCN1 PKHD1L1 SVEP1 CRB1	5.16e-07	160	82	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS19 FBN2 HMCN1 PKHD1L1 SVEP1 CRB1	5.16e-07	160	82	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS19 FBN1 EFEMP1 HMCN1 CSMD2 SVEP1	1.73e-06	197	82	6	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 HMCN1 LHX6 PKHD1L1 UNC79	1.36e-05	165	82	5	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 HMCN1 LHX6 PKHD1L1 UNC79	1.36e-05	165	82	5	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	ADAMTS12 FBN1 FBN2 HMCN1 SVEP1	2.12e-05	181	82	5	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 EFEMP1 STARD9 ADGRB1 GJC1	2.29e-05	184	82	5	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2 EFEMP1 PKHD1L1 SVEP1	2.48e-05	187	82	5	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2 EFEMP1 PKHD1L1 SVEP1	2.48e-05	187	82	5	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2 EFEMP1 PKHD1L1 SVEP1	2.48e-05	187	82	5	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADAMTS12 FBN1 PLAGL2 RNF43 RUSC2	2.54e-05	188	82	5	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BCL6B FBN1 EFEMP1 ADAMTS7 PKHD1L1	2.54e-05	188	82	5	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BCL6B FBN1 EFEMP1 ADAMTS7 PKHD1L1	2.54e-05	188	82	5	3f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BCL6B FBN1 EFEMP1 ADAMTS7 PKHD1L1	2.54e-05	188	82	5	61ee7b152745164293d8a44ef91ee2393efbdca5
ToppCell	droplet-Lung-immune-endo-depleted\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 EFEMP1 LRP4 LTBP3 SVEP1	2.60e-05	189	82	5	c3fb363bb0156ffb3367c200f548faebda64ab4a
ToppCell	droplet-Lung-immune-endo-depleted-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 EFEMP1 LRP4 LTBP3 SVEP1	2.60e-05	189	82	5	2a2953f6b1b7d070d739dcaf7285fce6e097d9e4
ToppCell	droplet-Lung-3m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN1 EFEMP1 LRP4 LTBP3 SVEP1	2.60e-05	189	82	5	5a636e952da9b1fd26aa17f7b129054f2da322b5
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 EFEMP1 LRP4 LTBP3 SVEP1	2.67e-05	190	82	5	9cd147a174017ebda23cc47b6d4552d898acd092
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS12 FBN1 EFEMP1 ADAMTS9 GJC1	2.74e-05	191	82	5	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	BCL6B FBN1 HMCN1 ADAMTS7 LHX6	2.88e-05	193	82	5	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	facs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS19 HMCN1 FZD3 GJB4 LTBP3	2.88e-05	193	82	5	eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	BCL6B FBN1 HMCN1 ADAMTS7 LHX6	2.88e-05	193	82	5	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	ADAMTS12 FBN1 HMCN1 CSMD2 SVEP1	2.95e-05	194	82	5	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	facs-Skin-Anagen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS19 HMCN1 FZD3 GJB4 LTBP3	2.95e-05	194	82	5	5d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FBN1 FBN2 HMCN1 LRP4 CSMD2	3.02e-05	195	82	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FBN1 FBN2 HMCN1 LRP4 CSMD2	3.02e-05	195	82	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	ADAMTS12 FBN1 HMCN1 CSMD2 SVEP1	3.18e-05	197	82	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 FBN1 EFEMP1 NFATC2 SVEP1	3.18e-05	197	82	5	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 FBN1 EFEMP1 NFATC2 SVEP1	3.18e-05	197	82	5	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EFEMP1 LTBP3 LDLR RNF43 CRB1	3.18e-05	197	82	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	ADAMTS12 FBN1 HMCN1 CSMD2 SVEP1	3.18e-05	197	82	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS19 FBN1 FBN2 PLD3 SVEP1	3.33e-05	199	82	5	8d71e1fc92ee24deedf23fbb1a85a7fba0d8d436
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS19 FBN1 EFEMP1 PLD3 SVEP1	3.33e-05	199	82	5	da016849b804fbf80edbfa8f8f56c9df8bbf2d51
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS12 ADAMTS19 FBN1 EFEMP1 SVEP1	3.33e-05	199	82	5	95d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 FBN2 EFEMP1 ADAMTS7 LRP4	3.33e-05	199	82	5	e78f661b40da34768469549b6e755d330be6bbd8
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS19 FBN1 FBN2 PLD3 SVEP1	3.33e-05	199	82	5	49690494270981eec5b5261c59e0545dff90cc21
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 EFEMP1 HMCN1 STARD9 SVEP1	3.41e-05	200	82	5	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	Sepsis-Bac-SEP-Myeloid-cDC1\|Bac-SEP / Disease, condition lineage and cell class	FBN1 SPINK2 FZD3 LACC1 CRYBG3	3.41e-05	200	82	5	cd381644fd8b8674a017d267bfbb00f2668294ae
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 EFEMP1 HMCN1 STARD9 SVEP1	3.41e-05	200	82	5	3dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GSX1 ADAMTS7 LRP4 RNF43	1.27e-04	139	82	4	a957ea4e581646c76b16b6a7f89579b8c7ac35b6
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Adcy1_(Reticular_formation)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SPINK2 ADAMTS7 FER1L6	1.43e-04	55	82	3	a911a29c2db5bf32a209a9c01afc96c9f8b401f6
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Adcy1_(Reticular_formation)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	SPINK2 ADAMTS7 FER1L6	1.43e-04	55	82	3	cff015b3803f5c06afc8b22be057322e0dcbd4f2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS7 LACC1 NTN5 SVEP1	1.45e-04	144	82	4	cf9f049ab6cd80521598124f057c2debdde24788
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS7 LACC1 NTN5 SVEP1	1.45e-04	144	82	4	41eaeca54b3c39de417597267cbdb1f195dd885a
ToppCell	Bac-SEP-Lymphocyte-T_NK-CD8_TCM\|Bac-SEP / Disease, Lineage and Cell Type	FLT3LG SPINK2 SPATA21 GJC1	1.61e-04	148	82	4	5814bfb5060bac455334eb50d2a7b1f01c0b6831
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	WDR97 ZNF408 TRIM59 CRB1	1.61e-04	148	82	4	065177aaa63c0441d312260b43ecdac78c84ad03
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ZNF628 ADAMTS7 STARD9 RUSC2	1.74e-04	151	82	4	8ba15ab24fe2e71df0a2a7511ca451ad2376bd91
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FBN1 EFEMP1 ARSF ARRDC4	1.97e-04	156	82	4	bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCell	IIF-Lymphocyte-T_NK-ILC\|IIF / Disease, Lineage and Cell Type	FBN1 SPINK2 SPATA21 TRIM59	2.12e-04	159	82	4	55e4f21548f480ca414c00cbff5ec3b13bafd271
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	ADAMTS12 FBN1 HMCN1 SVEP1	2.12e-04	159	82	4	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	HMCN1 ADAMTS9 ADGRB1 GAL3ST3	2.12e-04	159	82	4	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ADAMTS12 ATXN7L2 ANGEL2 ZFPM1	2.12e-04	159	82	4	f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ADAMTS12 ATXN7L2 ANGEL2 ZFPM1	2.12e-04	159	82	4	929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FBN2 ZFPM1 CSMD2 TRIM59	2.17e-04	160	82	4	636127753e3a22831f39d4c8170df40901e4329d
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FBN2 ZFPM1 CSMD2 TRIM59	2.17e-04	160	82	4	cb8d0dc1a6c69c7a85c5fdd8f0f6cca1b73dfc63
ToppCell	3'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FCGBP LACC1 GJC1 FER1L6	2.28e-04	162	82	4	075f73ff10e1a7f5695e014e47acc4db513e9cfb
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBX22 ADAMTS19 FBN1 EFEMP1	2.28e-04	162	82	4	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	ATXN7L2 ARSF CRYBG3 LHX6	2.39e-04	164	82	4	4d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	ADAMTS12 FBN1 HMCN1 SVEP1	2.39e-04	164	82	4	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	severe-HSPC\|severe / disease stage, cell group and cell class	FBN1 SPINK2 ADGRB1 NTN5	2.44e-04	165	82	4	acd837d88ad3786c263f74651a6c0e02fa2fa2c5
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LACC1 EZH2 HNRNPLL LDLR	2.44e-04	165	82	4	94a5211072464fc24592bb107a853ce832e816fe
ToppCell	droplet-Fat-Bat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB17 SPINK2 NFATC2 LACC1	2.61e-04	168	82	4	6fddc957a0503455d8c165862b5eb8e5fdb8a510
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT3LG UNC79 RNF43 TRIM59	2.61e-04	168	82	4	273168eefe0dae5494ac6ff5306bb307f06dc9c5
ToppCell	droplet-Fat-Bat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB17 SPINK2 NFATC2 LACC1	2.61e-04	168	82	4	794035cb63353a7d02fd9939deb5b4d075c9d95a
ToppCell	droplet-Fat-Bat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB17 SPINK2 NFATC2 LACC1	2.61e-04	168	82	4	1e23b634f96e88b976a523ca1f3fc08f6fe9b239
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 FBN2 CRYBG3 SVEP1	2.67e-04	169	82	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FZD3 GJB4 ADGRB1 RNF43	2.67e-04	169	82	4	e3410ccb3f85811c75694e286115803911169a2f
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FZD3 GJB4 ADGRB1 RNF43	2.67e-04	169	82	4	a4f610d07c3ba5537f4497f523669b914f7eddc1
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBN1 SPATA21 GJB4 SVEP1	2.74e-04	170	82	4	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 FBN1 GJC1 EZH2	2.80e-04	171	82	4	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 FBN1 EFEMP1 SVEP1	2.80e-04	171	82	4	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 FBN1 GJC1 EZH2	2.80e-04	171	82	4	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 ADAMTS7 EZH2 TRIM59	2.86e-04	172	82	4	c06ca5d075937747952ed915c9db39a9f62072f9
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EFEMP1 ZNF764 RNF43 TRIM59	3.05e-04	175	82	4	334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 ADAMTS7 EZH2 TRIM59	3.05e-04	175	82	4	a154b28b0b2180652d51d4c7d804b3b81b35899e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 HMCN1 NFATC2 SVEP1	3.12e-04	176	82	4	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 HMCN1 NFATC2 SVEP1	3.12e-04	176	82	4	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 EFEMP1 LTBP3 SVEP1	3.12e-04	176	82	4	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 EFEMP1 LTBP3 SVEP1	3.12e-04	176	82	4	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	wk_15-18-Epithelial-PNS-Schwann_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TBX22 KMT2D NF1 CRB1	3.19e-04	177	82	4	5357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EFEMP1 NFATC2 ADAMTS9 PKHD1L1	3.19e-04	177	82	4	0912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	ADAMTS12 FBN1 HMCN1 SVEP1	3.26e-04	178	82	4	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	BCL6B NAIP CSMD2 SVEP1	3.33e-04	179	82	4	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS12 EFEMP1 TGFBRAP1 PKHD1L1	3.33e-04	179	82	4	40c65e8623547aeb80f9cd2366e29072467ce069
ToppCell	facs-Kidney-nan-24m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 EFEMP1 UNC79 SVEP1	3.40e-04	180	82	4	f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 NFATC2 STARD9 SVEP1	3.40e-04	180	82	4	280ff5c8f292be1b88120db5ff1788b750644856
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 NFATC2 STARD9 SVEP1	3.40e-04	180	82	4	fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBN1 EFEMP1 LRP4 SVEP1	3.47e-04	181	82	4	091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 FBN1 HMCN1 SVEP1	3.47e-04	181	82	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B EFEMP1 ADAMTS9 PKHD1L1	3.54e-04	182	82	4	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 ARSF HMCN1 SVEP1	3.54e-04	182	82	4	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	P28-Mesenchymal\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBN1 EFEMP1 LRP4 SVEP1	3.54e-04	182	82	4	69f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 FBN2 ADGRB1 GJC1	3.62e-04	183	82	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	NS-critical-d_0-4-Lymphoid-Treg\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLT3LG NFATC2 KMT2A TRIM59	3.62e-04	183	82	4	f478dfa231fc1b12ead0183cc9d22077cdf43d1f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 HMCN1 PKHD1L1 UNC79	3.69e-04	184	82	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 EFEMP1 ADGRB1 GJC1	3.69e-04	184	82	4	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 HMCN1 PKHD1L1 UNC79	3.69e-04	184	82	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 HMCN1 PKHD1L1 UNC79	3.69e-04	184	82	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL6B EFEMP1 ADAMTS9 PKHD1L1	3.69e-04	184	82	4	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 FBN1 EFEMP1 SVEP1	3.77e-04	185	82	4	3cd0686a14e734a0f243070ab939adcb4c454478
Drug	Ramipril [87333-19-5]; Up 200; 9.6uM; MCF7; HT_HG-U133A	ADAMTS12 FBN1 ING1 LRP4 RNF17 TOP3A WDTC1	6.93e-06	196	82	7	3572_UP
Drug	Oxamniquine [21738-42-1]; Up 200; 14.4uM; MCF7; HT_HG-U133A	EFEMP1 NF1 ANGEL2 LHX6 RNF43 SVEP1 TOP3A	7.17e-06	197	82	7	7344_UP
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	2.07e-05	3	78	2	DOID:65 (implicated_via_orthology)
Disease	glioblastoma (is_implicated_in)	FLT3LG ADGRB1 EZH2	3.46e-05	24	78	3	DOID:3068 (is_implicated_in)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	4.12e-05	4	78	2	DOID:0060249 (is_implicated_in)
Disease	Geleophysic dysplasia	FBN1 LTBP3	6.86e-05	5	78	2	C3489726
Disease	Weaver syndrome	KMT2A EZH2	6.86e-05	5	78	2	C0265210
Disease	Acromicric Dysplasia	FBN1 LTBP3	6.86e-05	5	78	2	C0265287
Disease	acute lymphoblastic leukemia (implicated_via_orthology)	KMT2A EZH2	1.03e-04	6	78	2	DOID:9952 (implicated_via_orthology)
Disease	myelofibrosis (is_implicated_in)	KMT2A EZH2	1.91e-04	8	78	2	DOID:4971 (is_implicated_in)
Disease	Microphthalmos	KMT2D CRB1	3.74e-04	11	78	2	C0026010
Disease	gastric adenocarcinoma (is_implicated_in)	KMT2D RNF43	3.74e-04	11	78	2	DOID:3717 (is_implicated_in)
Disease	Endometrial Neoplasms	CHFR EZH2 RNF43	4.94e-04	58	78	3	C0014170
Disease	colon cancer (is_marker_for)	NF1 EZH2 RNF43	5.19e-04	59	78	3	DOID:219 (is_marker_for)
Disease	stomach cancer (is_marker_for)	KMT2D ADGRB1 EZH2 RNF43	5.56e-04	142	78	4	DOID:10534 (is_marker_for)
Disease	oral squamous cell carcinoma (is_marker_for)	KMT2D NAIP EZH2	6.30e-04	63	78	3	DOID:0050866 (is_marker_for)
Disease	cortical thickness	FBN1 FBN2 ADAMTS7 ADAMTS9 FZD3 ARRDC4 LRP4 KMT2A CAMTA1 CLUH	6.88e-04	1113	78	10	EFO_0004840
Disease	Lymphoma, Large-Cell, Follicular	KMT2D EZH2	7.08e-04	15	78	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	KMT2D EZH2	7.08e-04	15	78	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	KMT2D EZH2	7.08e-04	15	78	2	C0079758
Disease	Lymphoma, Follicular, Grade 2	KMT2D EZH2	7.08e-04	15	78	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	KMT2D EZH2	7.08e-04	15	78	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	KMT2D EZH2	7.08e-04	15	78	2	C1956130
Disease	uterine prolapse	FBN2 EFEMP1	8.08e-04	16	78	2	EFO_1001864
Disease	Endometrial Carcinoma	CHFR EZH2 RNF43	9.29e-04	72	78	3	C0476089
Disease	Hereditary Diffuse Gastric Cancer	FCGBP ING1 CHFR KMT2A RNF43	1.09e-03	293	78	5	C1708349
Disease	Juvenile Myelomonocytic Leukemia	NF1 EZH2	1.15e-03	19	78	2	C0349639
Disease	Stomach Neoplasms	FCGBP ING1 CHFR KMT2A RNF43	1.16e-03	297	78	5	C0038356
Disease	Malignant neoplasm of stomach	FCGBP ING1 CHFR KMT2A RNF43	1.21e-03	300	78	5	C0024623
Disease	Lymphoma, Follicular	KMT2D EZH2	1.27e-03	20	78	2	C0024301
Disease	central corneal thickness	ADAMTS19 FBN1 FBN2 EFEMP1 KMT2A	1.38e-03	309	78	5	EFO_0005213
Disease	acute myeloid leukemia (is_implicated_in)	NF1 KMT2A EZH2	1.45e-03	84	78	3	DOID:9119 (is_implicated_in)
Disease	cholangiocarcinoma (is_implicated_in)	EZH2 RNF43	1.54e-03	22	78	2	DOID:4947 (is_implicated_in)
Disease	open-angle glaucoma	EFEMP1 KMT2A LTBP3 SVEP1	1.67e-03	191	78	4	EFO_0004190
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	KMT2D NF1	1.68e-03	23	78	2	C1708353
Disease	malignant astrocytoma (is_marker_for)	NF1 ADGRB1	1.68e-03	23	78	2	DOID:3069 (is_marker_for)
Disease	Agents acting on the renin-angiotensin system use measurement	FBN2 NFATC2 LDLR RNF43 SVEP1	1.96e-03	335	78	5	EFO_0009931
Disease	obsessive-compulsive disorder, Tourette syndrome	NFATC2 CAMTA1	2.15e-03	26	78	2	EFO_0004242, EFO_0004895
Disease	intraocular pressure measurement	FBN1 FBN2 EFEMP1 LRP4 KMT2A LTBP3	2.30e-03	509	78	6	EFO_0004695

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLDDHTRCFPNCPFL	NAIP	331	Q13075
CRCFGEQVTYHNPPL	ARSF	491	P54793
IQPGVLRCYCPAHDT	CAMTA1	916	Q9Y6Y1
YLQFEGPPPICEVHC	CSMD2	2341	Q7Z408
IELFPQSDPACCPVY	CRYBG3	2391	Q68DQ2
YRQCGTQRCPEPHEI	ADGRB1	566	O14514
CPAICVANTHLLYNP	ANGEL2	301	Q5VTE6
HSPVYQTTCCLQPSP	DISP1	131	Q96F81
CHYATRPPRPQAFCT	ATXN7L2	401	Q5T6C5
IFNPAHPCELYCRPI	ADAMTS12	626	P58397
HPCELYCRPIDGQFS	ADAMTS12	631	P58397
VNPCELHCRPANEYF	ADAMTS7	626	Q9UKP4
CPVFACIQEFRFQPP	ARRDC4	381	Q8NCT1
KPAAYRPCHLQPCNE	ADAMTS19	1131	Q8TE59
PPSCVLHYYNVPLCV	HNRNPLL	451	Q8WVV9
LCPQFQNIPAHYSPR	NFATC2	201	Q13469
NQRPAPCYDPCEAVL	PLD3	71	Q8IV08
HVYNYQPCDHPRQPC	EZH2	516	Q15910
CAFQPPPSCLRFVQT	FLT3LG	111	P49771
CGPNVINHYFCDLVP	OR4X2	161	Q8NGF9
YPNERVCPFPQCRKS	ZFPM1	286	Q8IX07
QTSYPLPDPRQFHCI	GSX1	121	Q9H4S2
LHPACVQLFDSPNPC	LACC1	356	Q8IV20
QFYPPGCRVTCLDPN	METTL7B	86	Q6UX53
QCGQVHCRLPYTAPP	LHX6	326	Q9UPM6
CSQYRLPGCPRHFNP	SPINK2	36	P20155
YQCIDTPCPPNYQRD	HMCN1	5496	Q96RW7
LPHPSCEHQFCYPRN	GAL3ST3	96	Q96A11
GTQPPSVHPCYLRDC	ADAMTS9	1661	Q9P2N4
CPEYRRQAAQPPHCP	CHFR	431	Q96EP1
PYPCPTCGTRFRHLQ	BCL6B	411	Q8N143
TFCPMECPPNSHYEL	FCGBP	1526	Q9Y6R7
YRCECPPGHQLSPNI	FBN1	1136	P35555
FQVHPFYVCSRLPCP	GJC1	201	P36383
VEPCPHTVDCYISRP	GJB4	166	Q9NTQ9
ACTPPAEYSPAQRQC	LTBP3	1061	Q9NS15
HVRDCSPPCPNMYFR	FZD3	181	Q9NPG1
CRNSYHPECLGPNYP	KMT2A	1501	Q03164
PGRYECNCPPDFQLN	FBN2	1551	P35556
HQDPIYPVCICPAGY	CRB1	126	P82279
ENLPTRCGFCHIPYD	C2CD5	456	Q86YS7
SIPEQYICYICRDPP	PHF20L1	716	A8MW92
PPYCHQRCVNTPGSF	EFEMP1	221	Q12805
QDPYILTPENRCVCP	EFEMP1	366	Q12805
FFCPQCRALQAPDPT	HSCB	56	Q8IWL3
EPPRLCYHPIFCGNL	FER1L6	931	Q2WGJ9
YRPHCEPCPAVADLT	RUSC2	366	Q8N2Y8
QSPYAQVPCILLCPQ	SPATA21	396	Q7Z572
ADPCYDPQGRPQFCL	NTN5	16	Q8WTR8
LPIDPNEPTYCLCNQ	ING1	346	Q9UK53
TAEGRPCPYPHCQVL	RNF43	751	Q68DV7
FQPHCELQPHCELQP	STARD9	1281	Q9P2P6
MPCHPCPRDYYQPNA	SVEP1	1121	Q4LDE5
PQPEQRPYSCPQLHC	PLAGL2	61	Q9UPG8
NCFLSSYPNPVAHLP	CLUH	846	O75153
YPDIPQFCIPCQLHN	RNF17	1281	Q9BXT8
QYRHPCAPSVPRYDQ	SAV1	261	Q9H4B6
NSPRIPCPCQLIEAY	TMEM268	316	Q5VZI3
HCSFSQPVFPYLNPR	TRIM5	466	Q9C035
CQNPFCEPVFVRYPN	TGFBRAP1	821	Q8WUH2
SIVNCLQPHPSYCFL	WDTC1	581	Q8N5D0
HPRVNFCPLPSEQCY	TRIP6	41	Q15654
CIIPRFYVHPDSPCS	TBX22	171	Q9Y458
HCLRPICFPGYVPNS	WDR97	1036	A6NE52
ERPYRCPHCADAFPQ	ZNF408	521	Q9H9D4
CVYFVPPTGHCLRPL	SEPTIN12	161	Q8IYM1
QEALPPPCESEIYCH	TREH	21	O43280
EFPPQLRSVCHCLYQ	NF1	1356	P21359
QAYCCILQDCFPVHP	PKHD1L1	3001	Q86WI1
DSSVCPVCQPHPVYR	TOP3A	701	Q13472
PYVCIHCQRQFADPG	ZBTB17	501	Q13105
PLCRQFANSVLPCYP	UBR3	1361	Q6ZT12
CQPYLQDVPRIQHCP	PRR29	136	P0C7W0
PKDPYCHPVCANRFS	GTF3C5	66	Q9Y5Q8
EPNPVPNFIHCRSYL	PIEZO1	1141	Q92508
PCLVCNNPEVPFCYI	UBR4	3531	Q5T4S7
VVHTGQRPYPCPECD	ZNF425	266	Q6IV72
TCPEHYRQPLNVYCL	TRIM59	96	Q8IWR1
PPVPRADQRHGCYVC	ZNF764	166	Q96H86
FYQRQHRLPEPSCPQ	TYK2	826	P29597
SCPQLRHYFQQPPRC	UNC79	1371	Q9P2D8
HTGERPYQCPDCPKA	ZNF628	86	Q5EBL2
SIPCRSPGCPRLYHF	KMT2D	181	O14686
GCQYLCLPAPQINPH	LDLR	676	P01130
VPAPPCNLEEFQCAY	LRP4	186	O75096