Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetallodipeptidase activity

DPEP1 DPEP2 DPEP3

5.50e-05101573GO:0070573
GeneOntologyMolecularFunctionmagnesium:sodium antiporter activity

SLC41A3 SLC41A1

6.14e-0521572GO:0061768
GeneOntologyMolecularFunctionphosphoglycerate kinase activity

PGK1 PGK2

6.14e-0521572GO:0004618
GeneOntologyMolecularFunctionphosphotransferase activity, carboxyl group as acceptor

PGK1 PGK2

1.83e-0431572GO:0016774
GeneOntologyMolecularFunctiondipeptidase activity

DPEP1 DPEP2 DPEP3

3.57e-04181573GO:0016805
GeneOntologyMolecularFunctionacid-ammonia (or amide) ligase activity

LGSN NADSYN1

3.65e-0441572GO:0016880
DomainRenal_dipep_fam

DPEP1 DPEP2 DPEP3

5.50e-0731543IPR008257
DomainPeptidase_M19

DPEP1 DPEP2 DPEP3

5.50e-0731543PF01244
DomainDipep_AS

DPEP1 DPEP2 DPEP3

5.50e-0731543IPR000180
DomainRENAL_DIPEPTIDASE_1

DPEP1 DPEP2 DPEP3

5.50e-0731543PS00869
DomainRENAL_DIPEPTIDASE_2

DPEP1 DPEP2 DPEP3

5.50e-0731543PS51365
DomainHEAT

CAND1 BTAF1 RPTOR HEATR3 SYMPK

4.59e-05481545PF02985
DomainPGLYCERATE_KINASE

PGK1 PGK2

6.75e-0521542PS00111
DomainPhosphoglycerate_kinase_N

PGK1 PGK2

6.75e-0521542IPR015824
Domain-

PGK1 PGK2

6.75e-05215423.40.50.1270
Domain-

PGK1 PGK2

6.75e-05215423.40.50.1260
DomainPGK

PGK1 PGK2

6.75e-0521542PF00162
DomainPhosphoglycerate_kinase_CS

PGK1 PGK2

6.75e-0521542IPR015911
DomainPhosphoglycerate_kinase_C

PGK1 PGK2

6.75e-0521542IPR015901
DomainHEAT

CAND1 BTAF1 RPTOR HEATR3 SYMPK

1.15e-04581545IPR000357
Domain-

SLC41A3 SLC41A1

2.02e-04315421.10.357.20
DomainMgtE

SLC41A3 SLC41A1

2.02e-0431542PF01769
DomainPhosphoglycerate_kinase

PGK1 PGK2

2.02e-0431542IPR001576
DomainSLC41_membr_dom

SLC41A3 SLC41A1

2.02e-0431542IPR006667
DomainSec63

ASCC3 SNRNP200

4.01e-0441542PF02889
DomainSec63

ASCC3 SNRNP200

4.01e-0441542SM00973
DomainSec63-dom

ASCC3 SNRNP200

4.01e-0441542IPR004179
DomainARM-like

CAND1 BTAF1 PELP1 RPTOR CTNNBL1 LRBA HEATR3 ARMH4 SYMPK

4.12e-042701549IPR011989
DomainARM-type_fold

CAND1 UBR4 BTAF1 PELP1 RPTOR EIF2B5 CTNNBL1 LRBA HEATR3 SYMPK

5.19e-0433915410IPR016024
DomainFA58C

CNTNAP1 SSPOP F8

6.56e-04211543SM00231
DomainFA58C_3

CNTNAP1 SSPOP F8

6.56e-04211543PS50022
DomainFA58C_1

CNTNAP1 SSPOP F8

6.56e-04211543PS01285
DomainFA58C_2

CNTNAP1 SSPOP F8

6.56e-04211543PS01286
DomainRNase_CAF1

CNOT8 CNOT7

6.65e-0451542IPR006941
DomainCAF1

CNOT8 CNOT7

6.65e-0451542PF04857
DomainF5_F8_type_C

CNTNAP1 SSPOP F8

9.80e-04241543PF00754
DomainFA58C

CNTNAP1 SSPOP F8

9.80e-04241543IPR000421
DomainMetal_Hydrolase

DPEP1 DPEP2 DPEP3

9.80e-04241543IPR032466
PathwayREACTOME_LTC4_CYSLTR_MEDIATED_IL4_PRODUCTION

DPEP1 DPEP2 DPEP3

1.76e-0571143M29845
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TANC2 POLR2A DUSP5 UBR4 RAPGEF1 PFAS BTAF1 ARHGEF11 BIRC6 ZC3H11A NADSYN1 DST RPTOR ANKRD11 LRRC56 PLA2G6 DISP2 SH3BP5L LTBP3 LRBA UVRAG PCNT SYMPK

1.85e-0911051612335748872
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NCOA2 TANC2 TPP2 CAND1 UBR4 CNTNAP1 MPDZ PPFIA3 ARHGEF11 UBN2 PGK1 SLC12A5 DST PELP1 PTPRN2 PRRC2C RPTOR DCHS1 SSH2 TBL1X PCNT

4.45e-099631612128671696
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CCDC170 PCLO POLR2A LYG2 UBR4 PPFIA3 BIRC6 SSPOP TMEM260 DST R3HCC1L PTPRN2 PKHD1 CTNNBL1 CHRD SNRNP200 HEATR3 SYMPK

1.08e-087361611829676528
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

TPP2 ANXA6 POLR2A UBR4 PFAS BIRC6 PGK1 ZC3H11A DST PELP1 PRRC2C ASCC3 ATP2A2 SNRNP200 HERC5 PCNT SYMPK

1.15e-086531611722586326
Pubmed

Identification of two additional members of the membrane-bound dipeptidase family.

DPEP1 DPEP2 DPEP3

9.74e-083161312738806
Pubmed

Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.

DPEP1 DPEP2 DPEP3

9.74e-083161332325220
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NCOA2 NR2C2 HDAC6 POLR2A UBR4 BTAF1 MSH3 ZC3H11A PELP1 PRRC2C SIX5 SNRNP200 GAA HERC5 SMAD4 TBL1X SYMPK

5.46e-078571611725609649
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

TRAF2 CAND1 HDAC6 POLR2A UBR4 PFAS MSH3 TSSC4 BIRC6 PGK1 NGDN ARG1 ZC3H11A DST RPTOR EIF2B5 CTNNBL1 ASCC3 ATP2A2 ZNF281 SNRNP200

1.29e-0613531612129467282
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SCFD2 NCOA2 TANC2 TRAF2 ANXA6 UBR4 TAB2 PPFIA3 CNOT8 NGDN PTPRN2 ZNF281 UTY RAVER1

1.80e-066381611431182584
Pubmed

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.

NR2C2 TRAF2 TAB2

1.93e-066161316446357
Pubmed

Defining the membrane proteome of NK cells.

CAND1 PDGFRA ANXA6 UBR4 OGFOD3 MSH3 TUBGCP2 BIRC6 PGK1 PELP1 INTS2 PRRC2C CNOT7 CTNNBL1 PLD1 LRBA ASCC3 GAA PCNT

2.19e-0611681611919946888
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

TANC2 ACOT13 POLR2A UBR4 MPDZ TUBGCP2 PGK1 ZFX DMXL1 PRRC2C INPP5J MAST3

2.43e-064751611231040226
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

COL17A1 ARHGEF11 SSPOP DST PTPRN2 SNRNP200 MAST3

2.62e-06130161712421765
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SCFD2 TPP2 CAND1 ANXA6 UBR4 BTAF1 TUBGCP2 UBN2 SNX19 DST PELP1 METTL9 PRRC2C CNOT7 EIF2B5 ASCC3 ATP2A2 SNRNP200 HEATR3 HERC5 RAVER1

3.43e-0614401612130833792
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DEAF1 HDAC6 POLR2A BTAF1 TSSC4 ADCY6 ZFX ZC3H11A SLC41A3 RPTOR EIF2B5 ATP2A2 SNRNP200 SYMPK RAVER1

3.48e-067741611515302935
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

TPP2 TRAF2 UBR4 MPDZ NADSYN1 DST MAP7D2 PCNT

7.06e-06212161833853758
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

CAND1 UBR4 PELP1 PRRC2C SNRNP200 HEATR3 TBL1X

7.69e-06153161726365490
Pubmed

Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.

NR2C2 TRAF2 TAB2

8.01e-069161314633987
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

CAND1 UBR4 PEX1 BTAF1 TUBGCP2 WLS TMUB1 RPTOR EIF2B5 ASCC3 ATP2A2 ZNF281 HEATR3 GAA SYMPK RAVER1

8.58e-069421611631073040
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NR2C2 DEAF1 POLR2A MSH3 UBN2 ZFX NGDN ZC3H11A DST PELP1 INTS2 ANKRD11 ATP2A2 ZNF281 SNRNP200 SMAD4 TBL1X SYMPK RAVER1

9.46e-0612941611930804502
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NCOA2 CAND1 ANXA6 EVC ANKMY1 BTAF1 UBN2 SSPOP ZC3H11A NADSYN1 SLC41A3 INTS2 PTPRN2 RPTOR ANKRD11 PLA2G6 LRBA TBL1X PCNT RAVER1

1.97e-0514891612028611215
Pubmed

Conservation of the deadenylase activity of proteins of the Caf1 family in human.

CNOT8 CNOT7

2.13e-052161215769875
Pubmed

Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts.

TRAF2 SMAD4

2.13e-052161219836350
Pubmed

A factor stimulating transcription of the testis-specific Pgk-2 gene recognizes a sequence similar to the binding site for a transcription inhibitor of the somatic-type Pgk-1 gene.

PGK1 PGK2

2.13e-05216128441629
Pubmed

Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex.

NR2C2 TAB2

2.13e-052161224942571
Pubmed

Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux system.

SLC41A3 SLC41A1

2.13e-052161227302215
Pubmed

The family of mouse phosphoglycerate kinase genes and pseudogenes.

PGK1 PGK2

2.13e-05216122829366
Pubmed

Characterization of phosphoglycerate kinase from human spermatozoa.

PGK1 PGK2

2.13e-05216121278465
Pubmed

Circulating anti-BP180 NC16a and anti-BP230 autoantibodies in patients with genital lichen sclerosus do not correlate with disease activity and pruritus.

COL17A1 DST

2.13e-052161224676719
Pubmed

Analysis of the cDNA and encoded protein of the human testis-specific PGK-2 gene.

PGK1 PGK2

2.13e-05216129023984
Pubmed

Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid.

COL17A1 DST

2.13e-052161217920818
Pubmed

High expression of Zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage II/III colorectal cancer patients.

DUSP5 ZFX

2.13e-052161226967242
Pubmed

Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene.

PGK1 PGK2

2.13e-05216123453121
Pubmed

Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects.

CNTNAP1 ADCY6

2.13e-052161224319099
Pubmed

Transcription switch of two phosphoglycerate kinase genes during spermatogenesis as determined with mouse testis sections in situ.

PGK1 PGK2

2.13e-05216122298243
Pubmed

Selective activation of testis-specific genes in cultured rat spermatogenic cells.

PGK1 PGK2

2.13e-05216122166582
Pubmed

CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.

CNOT8 CNOT7

2.13e-052161235248544
Pubmed

The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

CNOT8 CNOT7

2.13e-052161219605561
Pubmed

Human phosphoglycerate kinase. I. Crystallization and characterization of normal enzyme.

PGK1 PGK2

2.13e-05216125009693
Pubmed

Cloning of partial cDNA for mouse 180-kDa bullous pemphigoid antigen (BPAG2), a highly conserved collagenous protein of the cutaneous basement membrane zone.

COL17A1 DST

2.13e-05216121512460
Pubmed

Differential appearance of DNase I-hypersensitive sites correlates with differential transcription of Pgk genes during spermatogenesis in the mouse.

PGK1 PGK2

2.13e-05216128662942
Pubmed

What's new in the pathogeneses and triggering factors of bullous pemphigoid.

COL17A1 DST

2.13e-052161236412277
Pubmed

SLC41A1 knockout mice display normal magnesium homeostasis.

SLC41A3 SLC41A1

2.13e-052161236049064
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

POLR2A UBR4 MSH3 PGK1 ZC3H11A PELP1 CTNNBL1 SNRNP200 SYMPK

2.65e-05332161932786267
Pubmed

Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning.

PGK1 ACAN CHRD

3.41e-0514161323313125
Pubmed

Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.

F8 PGK1 ZFX

3.41e-051416138432533
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PCLO UBR4 EML6 ATP10B OGFOD3 PTPN21 PGK1 ADCY6 PGK2 NGDN DST PRRC2C PKHD1 MAP7D2 ABCC2 ATP12A TMPRSS7 ATP2A2 PCNT

4.17e-0514421611935575683
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

POLR2A PELP1 PRRC2C PKHD1 ASCC3 ATP2A2 SNRNP200

4.60e-05202161724639526
Pubmed

Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2.

MPDZ MSH3 F8 STK39

5.68e-0545161427337956
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOA2 TPP2 NR2C2 CAND1 DEAF1 ANXA6 TUBGCP2 UBN2 PGK1 ZC3H11A PRRC2C ATP2A2 ZNF281 SNRNP200 HEATR3 RAVER1

5.76e-0511031611634189442
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

CAND1 UBR4 TAB2 BTAF1 TUBGCP2 WLS BIRC6 INTS2 EIF2B5 ATP2A2 SNRNP200 HEATR3

6.04e-056571611236180527
Pubmed

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.

PDGFRA POLR2A DCHS1

6.31e-0517161332155439
Pubmed

Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.

IFNG RPTOR

6.37e-053161217656678
Pubmed

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.

PGK1 PGK2

6.37e-05316121380672
Pubmed

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.

CNOT8 CNOT7

6.37e-053161237767629
Pubmed

The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.

SLC41A3 SLC41A1

6.37e-053161212810078
Pubmed

Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.

CNOT8 CNOT7

6.37e-053161233021411
Pubmed

Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase.

IFNG SMAD4

6.37e-053161236045676
Pubmed

Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.

NCOA2 NR5A2

6.37e-053161222504882
Pubmed

Prognostic value of novel biomarkers in astrocytic brain tumors: nuclear receptor co-regulators AIB1, TIF2, and PELP1 are associated with high tumor grade and worse patient prognosis.

NCOA2 PELP1

6.37e-053161221735116
Pubmed

Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development.

IFNG PLA2G6

6.37e-053161225004092
Pubmed

Bullous pemphigoid antigen: cDNA cloning, cellular expression, and evidence for polymorphism of the human gene.

COL17A1 DST

6.37e-05316122045679
Pubmed

The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.

CNOT8 CNOT7

6.37e-053161227605379
Pubmed

Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.

NCOA2 NR5A2

6.37e-053161226553876
Pubmed

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.

CNOT8 CNOT7

6.37e-053161220065043
Pubmed

ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.

CAND1 ASCC3

6.37e-053161238148115
Pubmed

Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.

CCDC170 WLS

6.37e-053161226911590
Pubmed

Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.

POLR2A SYMPK

6.37e-053161220861839
Pubmed

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.

CNOT8 CNOT7

6.37e-053161225944446
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

MSH3 TUBGCP2 HAUS8 PELP1 RPTOR CNOT7 EIF2B5 SNRNP200 HEATR3 SYMPK RAVER1

6.49e-055601611135241646
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CAND1 BIRC6 HAUS8 ZC3H11A PELP1 INTS2 PRRC2C CTNNBL1 ASCC3 ZNF281

7.16e-054691611027634302
Pubmed

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.

NCOA2 POLR2A MSH3

8.93e-0519161314578343
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TAB2 PPFIA3 BIRC6 ADCY6 DST SNRNP200 PCNT

9.06e-05225161712168954
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NCOA2 TRAF2 CAND1 HDAC6 UBR4 CNTNAP1 MSH3 PGK1 MOAP1 CNOT8 DST LTBP3 LRBA CARS2 ATP2A2 SNRNP200 PCNT

1.03e-0412851611735914814
Pubmed

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.

CNOT8 CNOT7 RAVER1

1.05e-0420161334887419
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 TRAF2 CAND1 ACOT13 ANXA6 PCLO POLR2A UBR4 PFAS MSH3 PGK1 ZC3H11A PELP1 RPTOR EIF2B5 CTNNBL1 ATP2A2 SNRNP200

1.14e-0414251611830948266
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

TPP2 POLR2A DUSP5 PFAS TAB2 PTPN21 PPFIA3 BIRC6 SNX19 PTPRN2 SSH2 ATP2A2 PCNT SYMPK RAVER1

1.16e-0410491611527880917
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

CAND1 POLR2A PFAS BTAF1 PGK1 ZC3H11A DST R3HCC1L PRRC2C LRBA ZNF281 SNRNP200 HERC5 PCNT

1.21e-049341611433916271
Pubmed

Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.

CNOT8 CNOT7

1.27e-044161211136725
Pubmed

Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.

RPTOR SLC37A2

1.27e-044161236170813
Pubmed

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

COL17A1 DST

1.27e-044161214668477
Pubmed

Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins.

PDGFRA RAPGEF1

1.27e-04416129546424
Pubmed

Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.

CNOT8 CNOT7

1.27e-044161211747467
Pubmed

Analysis of male meiotic "sex body" proteins during XY female meiosis provides new insights into their functions.

POLR2A PGK1

1.27e-044161211072798
Pubmed

NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases.

HDAC6 ATP12A

1.27e-044161212372765
Pubmed

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.

CNOT8 CNOT7

1.27e-04416129820826
Pubmed

ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole.

TUBGCP2 PCNT

1.27e-044161226213385
Pubmed

HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.

NR2C2 HDAC6

1.27e-044161236270986
Pubmed

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

CNOT8 CNOT7

1.27e-044161223236473
Pubmed

Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation.

CNOT8 CNOT7

1.27e-044161220595394
Pubmed

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.

SLC12A5 STK39

1.27e-044161231615901
Pubmed

Activation of the alpha3 integrin affects TRAF6 function in the IL-1 signaling pathway of CACO-2 epithelial cells.

NR2C2 TAB2

1.27e-044161220064081
Pubmed

Sex differences play a role in cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis induced by pressure overload and thapsigargin.

TRAF2 ATP2A2

1.27e-044161220850991
Pubmed

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.

PDGFRA POLR2A RAVER1

1.41e-0422161319483677
Pubmed

A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.

METTL9 EIF2B5 CTNNBL1 SNRNP200

1.44e-0457161416730941
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

CAND1 CNOT8 PRRC2C CNOT7 ATP2A2

1.45e-04107161530995489
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

CAND1 PDGFRA UBR4 PFAS BIRC6 ZFX ZC3H11A TRMT44 PELP1 INTS2 PTPRN2 PAFAH1B2 NR5A2 ANKRD11 SSH2 HEATR3 PCNT

1.51e-0413271611732694731
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

TRAF2 HDAC6 POLR2A UBR4 BTAF1 BIRC6 RPTOR CARS2 HEATR3 RAVER1

1.54e-045151611031617661
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

HDAC6 CNTNAP1 RAPGEF1 PPFIA3 ARHGEF11 PTPRN2 CHRD LRBA

1.58e-04329161817474147
Pubmed

Intestinal epithelial cells secrete exosome-like vesicles.

DPEP1 PGK1 IFNG

1.61e-0423161311487543
InteractionCD70 interactions

NR2C2 BTAF1 ADCY6 INTS2 METTL9 EIF2B5 LRBA HEATR3 HERC5

5.95e-061661569int:CD70
InteractionSIRT7 interactions

TPP2 ANXA6 POLR2A UBR4 PFAS BIRC6 PGK1 ZC3H11A DST PELP1 PRRC2C CTNNBL1 ASCC3 ATP2A2 SNRNP200 HERC5 PCNT SYMPK

1.89e-0574415618int:SIRT7
InteractionRNF123 interactions

CCDC170 PCLO POLR2A LYG2 UBR4 PPFIA3 BIRC6 SSPOP TMEM260 DST R3HCC1L PTPRN2 PKHD1 CTNNBL1 CHRD SNRNP200 HEATR3 HERC5 SYMPK

2.13e-0582415619int:RNF123
InteractionLPIN3 interactions

TANC2 TRAF2 HDAC6 BIRC6 RPTOR MAST3

2.17e-05731566int:LPIN3
GeneFamilyWD repeat domain containing

FBXW9 EML6 DMXL1 RPTOR LRBA SPAG16 TBL1X

4.93e-04262967362
GeneFamilyPDZ domain containing

MAGIX PCLO MPDZ ARHGEF11 MAST3

1.30e-031529651220
GeneFamilyX-linked mental retardation|RNA helicases

ASCC3 SNRNP200

1.49e-03119621168
GeneFamilyCCR4-NOT transcription complex

CNOT8 CNOT7

1.49e-03119621023
CoexpressionGSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_DN

NCOA2 TANC2 DUSP5 WLS F8 HAUS8 TRMT44 SIX5 STK39

3.88e-062001599M8106
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC6 PCLO GIPR DST PTPRN2 PRRC2C ANKRD11 ASCC3 ATP2A2 UTY

2.26e-09195159107796ea9247f4c63762f0de8490fed08b9717fa23
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC6 PCLO DST PTPRN2 PRRC2C ANKRD11 ASCC3 ATP2A2 UTY

3.64e-0819515993e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA2 F8 EMILIN1 NADSYN1 CHRD ZNF518B LRBA SYMPK

3.65e-07186159837860daeecd6d412bd3797f30496a56da667fbd1
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA2 F8 EMILIN1 NADSYN1 CHRD ZNF518B LRBA SYMPK

3.65e-07186159860830822d3de3147816693404fd03392e04c2b8e
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA2 F8 EMILIN1 NADSYN1 CHRD ZNF518B LRBA SYMPK

3.65e-071861598baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO DUSP5 TSSC4 EMILIN1 DST PTPRN2 DISP2 ATP2A2

4.47e-0719115983387b95a3f2445c672d407922fdce3a91eabaef8
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC6 PCLO WLS GIPR DST PTPRN2 DISP2 ATP2A2

4.65e-0719215985b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NCOA2 TANC2 RAPGEF1 BIRC6 ANKRD11 SSH2 LRBA ARMH4

4.83e-071931598779276e775cb2492e8dd36436295a536084a6415
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO UBR4 EMILIN1 DST PTPRN2 DISP2 ATP2A2 GAA

4.83e-071931598471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO UBR4 EMILIN1 DST PTPRN2 DISP2 ATP2A2 GAA

4.83e-071931598fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO TSSC4 EMILIN1 DST PTPRN2 DISP2 ATP2A2 GAA

5.22e-071951598bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO UBN2 EMILIN1 DST PTPRN2 DISP2 ATP2A2

5.19e-061881597a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO WLS GIPR DST PTPRN2 DISP2 ATP2A2

5.76e-061911597f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY6 DST PKHD1 FGF9 STK39 LRBA INPP5J

5.76e-061911597297bc79adc5fef211497819b4861b52cd26ac754
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY6 DST PKHD1 FGF9 STK39 LRBA INPP5J

5.76e-061911597e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBR4 UBN2 DST PTPRN2 DISP2 ATP2A2 GAA

5.96e-0619215970dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBR4 EMILIN1 DST PTPRN2 DISP2 ATP2A2 GAA

6.38e-0619415973a3ecedcdc7691cf21775818b598208fcb980c29
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBR4 EMILIN1 DST PTPRN2 DISP2 ATP2A2 GAA

6.38e-0619415970b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

TANC2 PCLO ZC3H11A DST PRRC2C ANKRD11 ZNF281

7.53e-061991597c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CCDC170 EML6 ANKMY1 SPNS3 GIPR LRRC56 ATP12A

7.78e-06200159796701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Astrocyte|GW09 / Sample Type, Dataset, Time_group, and Cell type.

BOC FBXW9 SLC18B1 F8 ABCC2 SLC41A1

1.22e-05142159685e573616e54d41391b4ad8c3d38e4ca92112673
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Fgf10_(Lateral_dorsal_thalamic_nuclei_(LD))|Thalamus / BrainAtlas - Mouse McCarroll V32

ACTRT2 MOAP1 PKHD1 FCRL5

1.24e-05401594c645fd6bebf8a6c5aa6ff9d40105a3d65695496b
ToppCelldroplet-Fat-Bat-18m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

R3HCC1L INTS2 CHRD MAP7D2 EPHX3 TBL1X

3.37e-051701596c720d81bc29a8fd1f1249c6af408471d561f1d5d
ToppCelldroplet-Fat-Bat|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

R3HCC1L INTS2 CHRD MAP7D2 EPHX3 TBL1X

3.37e-051701596c4ecdfc2b4710da0a5fbb20e9df02536023badb1
ToppCell367C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TRAF2 AOC1 COL17A1 ANXA6 PCLO UVRAG

4.22e-051771596a0ff337f11bdb11959ac71805ff94be6b4ec1083
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO F8 GIPR DST PTPRN2 ATP2A2

4.36e-051781596fcbbcc44271515de1969b4732b6441c012693d5f
ToppCelldroplet-Spleen-SPLEEN-1m-Lymphocytic-plasma_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXW9 DUSP5 SSPOP LTBP3 SLC41A1 GAA

4.36e-051781596b902059c3f861108fc64cbdc05e6f44378f5be2c
ToppCellwk_20-22-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BOC FAM185A PCLO ZNF557 ACAN ARMH4

4.93e-05182159603a5a02acd48f0eb210485348bfe0cd21f486215
ToppCellfacs-Heart-LA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSD2 RASGEF1A ADCY6 ACAN MAP7D2 EPHX3

5.56e-051861596e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCellfacs-Heart-LA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSD2 RASGEF1A ADCY6 ACAN MAP7D2 EPHX3

5.56e-051861596fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCellSubstantia_nigra-Neuronal|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PCLO RASGEF1A SLC12A5 PTPRN2 MAP7D2 DISP2

5.56e-0518615963f889083fcffe516388e9b03a5e23af2010ced33
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-CLDN10+_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPEP1 RBPJL EML6 NR5A2 PKHD1 ATP12A

5.56e-05186159656d2f463800d189212ea0acaaf7db09b65a54eb6
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA CHRD LTBP3 ARMH4

6.63e-051921596a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO TSSC4 UBN2 DST PTPRN2 ATP2A2

6.63e-0519215961304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA CHRD LTBP3 ARMH4

6.63e-051921596eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BOC DPEP1 PDGFRA CHRD LTBP3 ARMH4

6.63e-05192159632acd89617934016cd135d2cc797e8e79ae1b37f
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA CHRD LTBP3 ARMH4

6.83e-051931596d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCLO PPFIA3 SLC12A5 PTPRN2 MAP7D2 DISP2

7.02e-0519415968aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO TSSC4 WLS DST PTPRN2 ATP2A2

7.02e-05194159692b39a935e8c577eb1123d706d168fa13cf3344c
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSSC4 EMILIN1 PTPRN2 MAP7D2 DISP2 ATP2A2

7.02e-051941596490645bfe9ed3dac03c191c7094df01c780b377e
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA EMILIN1 LTBP3 GAA

7.22e-05195159669a29d03e664b72f32d41876510c62345c3aed31
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA EMILIN1 LTBP3 GAA

7.22e-0519515961cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA EMILIN1 LTBP3 GAA

7.22e-0519515969cef6f18664518060af7c192310dddce6d70345a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANXA6 ZC3H11A PRRC2C LTBP3 SLC41A1 ATP2A2

7.43e-05196159666d76249bd2770cdddff2c1fe59a016e95da2124
ToppCellcontrol-immature_Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TANC2 UBR4 ARHGEF11 ZNF518B GAA TBL1X

7.43e-051961596e34fd3e7a5b1c22a81fd3208e6d58bdb846d51c4
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANXA6 ZC3H11A PRRC2C LTBP3 SLC41A1 ATP2A2

7.43e-0519615969bd4c146fc7555e32adfa393b3a07846eb826d25
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WLS EMILIN1 DST LTBP3 ATP2A2 GAA

7.64e-051971596e77016d64b1cac9825fec7cfe5071f1567401187
ToppCellParenchyma_Control_(B.)-Immune-TX-MoAM-4|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

DUSP5 RASGEF1A ZFX HAUS8 SLC37A2 SMAD4

7.64e-051971596dc1c55e3aacc9d60d0f111c2f20f150ca296f011
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WLS EMILIN1 DST LTBP3 ATP2A2 GAA

7.64e-0519715960353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

CCDC170 MBD3L1 ATP10B ARG1 ATP12A EPHX3

7.86e-051981596e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

CCDC170 MBD3L1 ATP10B ARG1 ATP12A EPHX3

7.86e-051981596ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BTAF1 PRRC2C ANKRD11 LRBA SNRNP200 UTY

8.08e-051991596f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Airway-Club|LPS_only / Treatment groups by lineage, cell group, cell type

CCDC170 MBD3L1 ATP10B ARG1 ATP12A EPHX3

8.08e-051991596165ac94b2d56072ad43358b5127d77555221e2d8
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 BIRC6 STK39 SSH2 LRBA UTY

8.08e-05199159694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC PDGFRA WLS EMILIN1 LTBP3 GAA

8.08e-05199159667f78c070c56e44fba36542041bf7fa1c291807c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC PDGFRA WLS EMILIN1 LTBP3 GAA

8.08e-0519915961ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MPDZ BIRC6 DST NR5A2 ZNF518B PCNT

8.31e-052001596dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA CHRD ZNF281

1.04e-041301595e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

BTAF1 PRRC2C PKHD1 SIX5 LRBA

1.24e-041351595ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA CHRD ZNF281

1.37e-041381595e2659949944bdf39b23c7275e380a7a937e2726c
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC DPEP1 PDGFRA CHRD ZNF281

1.37e-041381595d5342383c5e52b92c39d7afe76560501be3ea5cd
DrugMethionylmethionine

DPEP1 DPEP2 DPEP3 GAA

2.60e-0791564CID000104294
DrugConessine [546-06-5]; Down 200; 11.2uM; MCF7; HT_HG-U133A

NCOA2 TANC2 OGFOD3 MSH3 PPFIA3 UTY MAST3 SMAD4 TBL1X

9.03e-0619715694777_DN
DrugOxethazaine [126-27-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A

NCOA2 NR2C2 HDAC6 TUBGCP2 WLS ARHGEF11 ZFX TBL1X SYMPK

9.79e-0619915691484_DN
DrugSC-11927

PGK1 PGK2 ARG1

1.08e-0571563CID003034422
Drug5-Acetamido-5,6-Dihydro-4-Hydroxy-6-Isobutoxy-4h-Pyran-2-Carboxylic Acid

BOC COL17A1 F8 CNOT8 DST GRIN3B

1.10e-05731566CID011963505
Drugcolchine

BOC COL17A1 SHBG ACTRT2 MOAP1 IFNG DST INTS2 PTPRN2 ACAN FGF9 TBL1X

1.38e-0538315612CID000002833
DrugD-glucamine

BOC COL17A1 IFNG DST SMAD4

1.39e-05451565CID000027282
Drugglycylvaline

BOC DPEP1 DPEP2 ACAN DPEP3

1.55e-05461565CID000097417
DrugNH4F

BOC F8 CNOT8

1.72e-0581563CID000014935
Drug5-fluorotryptophan

PFAS PGK1 PGK2 EIF2B5

2.40e-05251564CID000009577
Diseaselevel of dipeptidase 2 in blood serum

DPEP2 DPEP3

2.74e-0521552OBA_2041349
DiseaseAmelogenesis Imperfecta

COL17A1 PEX1 LTBP3

3.02e-05121553C0002452
DiseaseX-24020 measurement

AOC1 TUBGCP2

2.71e-0451552EFO_0022128
DiseaseColorectal Carcinoma

BOC DPEP1 BRINP1 SPNS3 TYMP SLC12A5 PTPRN2 PKHD1 DCHS1 ABCC2 SNRNP200 SMAD4

3.52e-0470215512C0009402
Diseasecomparative body size at age 10, self-reported

SHBG BRINP1 GIPR DPEP2 ACAN RPTOR PKHD1 CTNNBL1 SLC41A1

3.98e-044201559EFO_0009819
Diseaselethal congenital contracture syndrome (is_implicated_in)

CNTNAP1 ADCY6

5.66e-0471552DOID:0060558 (is_implicated_in)
DiseaseAdrenoleukodystrophy

PEX1 IFNG

5.66e-0471552C0162309
Diseaseunipolar depression

CCDC170 NCOA2 PCLO CNTNAP1 RASGEF1A BRINP1 SLC12A5 METTL9 PKHD1 DCHS1 ZNF80 LTBP3 PLD1 ASCC3 ATP2A2 SNRNP200

6.35e-04120615516EFO_0003761
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

AOC1 SNX19 GIPR ACAN RPTOR PKHD1 PLA2G6 SSH2

7.10e-043641558EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseasecocaine use disorder, social environment measurement

OGFOD3 STRADB

7.52e-0481552EFO_0010445, EFO_0010552
Diseasemetabolite measurement

DPEP1 AOC1 SHBG SLC12A5 ARG1 ZNF557 PTPRN2 NR5A2 ABCC2 UVRAG

7.88e-0456015510EFO_0004725
Diseaseatopic eczema, psoriasis

ANXA6 R3HCC1L PTPRN2

8.94e-04361553EFO_0000274, EFO_0000676
DiseaseLeishmaniasis

ARG1 IFNG

9.63e-0491552C0023281
Diseaseheart disease (implicated_via_orthology)

CNOT8 CNOT7 ATP2A2

1.05e-03381553DOID:114 (implicated_via_orthology)
Diseasebody fat percentage

AOC1 ZC3H11B SNX19 GIPR ACAN RPTOR PKHD1 PLA2G6 SSH2

1.15e-034881559EFO_0007800
Diseasedipeptidase 2 measurement

DPEP2 DPEP3

1.20e-03101552EFO_0801528
DiseaseN6-acetyllysine measurement

HDAC6 SHBG

1.20e-03101552EFO_0800036
Diseasefactor VIII deficiency (is_implicated_in)

F8 IFNG

1.46e-03111552DOID:12134 (is_implicated_in)
Diseaseserum metabolite measurement

TANC2 DPEP1 AOC1 SHBG PGK2 ARG1 SLC39A12 PTPRN2 STK39 ZNF518B FCRL5 ABCC2 ARMH4

1.50e-0394515513EFO_0005653
Diseaseendometrial carcinoma (is_implicated_in)

MSH3 SMAD4

1.75e-03121552DOID:2871 (is_implicated_in)
Diseaseobesity

EML6 ZC3H11B ARG1 GIPR RPTOR PKHD1

1.77e-032411556EFO_0001073
Diseaserisky sexual behaviour measurement

CCDC170 BIRC6 PTPRN2 ASCC3 MAST3

2.03e-031691555EFO_0007877
Diseasemelanoma

HDAC6 PDGFRA UBR4 IFNG SLC39A12 EPHX3

2.05e-032481556C0025202
Diseasemyeloid leukemia (is_implicated_in)

PDGFRA IFNG

2.06e-03131552DOID:8692 (is_implicated_in)
DiseaseHypermetropia

NADSYN1 PTPRN2 ANKRD11 ZNF281

2.16e-031031554HP_0000540
Diseasevitamin D measurement, COVID-19

TSKU NADSYN1 UVRAG

2.19e-03491553EFO_0004631, MONDO_0100096
Diseasebody surface area

AOC1 ZC3H11B GIPR ACAN RPTOR PKHD1 ANKRD11 PLA2G6 LTBP3 SYMPK

2.20e-0364315510EFO_0022196
Diseasedepressive symptom measurement, stressful life event measurement

PCLO TMEM260 ARMH4

2.33e-03501553EFO_0007006, EFO_0007781
Disease5-methyluridine (ribothymidine) measurement

PCLO TYMP

2.39e-03141552EFO_0020013
Diseasebody mass index, osteoarthritis

DPEP1 ZC3H11B TSKU

2.90e-03541553EFO_0004340, MONDO_0005178
Diseasediastolic blood pressure, systolic blood pressure

SCFD2 DPEP1 AOC1 ZC3H11B SNX19 SLC39A12 PELP1 ACAN PLD1 EPHX3

2.95e-0367015510EFO_0006335, EFO_0006336
Diseaseopen-angle glaucoma

SCFD2 ZC3H11B DST PKHD1 LTBP3

3.44e-031911555EFO_0004190
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

PCLO SNX19 RPTOR SPAG16 ATP2A2

4.19e-032001555EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Diseaseskin sensitivity to sun

DPEP1 ANKRD11

4.42e-03191552EFO_0004795
Diseaseplatelet crit

SCFD2 NCOA2 DEAF1 ARHGEF11 DCHS1 CHRD SLC41A1 EPHX3 HEATR3 GAA SMAD4 RAVER1

4.57e-0395215512EFO_0007985
Diseaserenal cell carcinoma (is_marker_for)

PDGFRA PFAS TYMP SMAD4

4.72e-031281554DOID:4450 (is_marker_for)
DiseaseAstigmatism

PDGFRA EML6 MPDZ ZC3H11B

4.85e-031291554HP_0000483
DiseaseBRCAX breast cancer

CCDC170 CTNNBL1

4.90e-03201552EFO_0009443
Diseaseobsolete_red blood cell distribution width

TPP2 SHBG TYMP BIRC6 F8 ZC3H11A PRRC2C RP1L1 PLA2G6 STK39 PLD1 GRIN3B HEATR3 MAST3 ARMH4

5.00e-03134715515EFO_0005192
Diseaseverbal-numerical reasoning measurement

NCOA2 BIRC6 TSKU PTPRN2

5.12e-031311554EFO_0008394

Protein segments in the cluster

PeptideGeneStartEntry
EEHTNAIGTLHGGLT

ACOT13

46

Q9NPJ3
AIGTLHGGLTATLVD

ACOT13

51

Q9NPJ3
SSEGSVGASLGQALH

ALS2CL

141

Q60I27
LGGGSRLEKQSLTHG

COL17A1

46

Q9UMD9
LGHGTYLQGLETEAT

ACOX2

156

Q99424
SRLGDGLGHVELTLS

CNTNAP1

401

P78357
SFLDGSRGLSHLGQV

ANKRD11

2101

Q6UB99
DISTLGHLVITTQGG

BIRC6

896

Q9NR09
LLGLLGHDNTDVSIA

CTNNBL1

146

Q8WYA6
GTHLLISATLGGEEA

BRINP1

126

O60477
GLSDHVSLDGQELGT

SH3BP5L

356

Q7L8J4
LSGGTTLFHGLDDRL

ACTRT2

301

Q8TDY3
DLLLGVHGLASSNET

ADCY6

866

O43306
EGETHTGTALLIAHG

ARMH4

371

Q86TY3
VLLSDHLGQSEAGGL

FGF9

31

P31371
HRELLKSLGGESSGG

ARHGEF11

1446

O15085
LHSLLVLVGGSEEGH

GIPR

241

P48546
GLLLSGALGTGRHTA

DNHD1

2886

Q96M86
GLELLVDHGSTDAGH

AOC1

216

P19801
SREDGSHILTVGIGS

DMXL1

1146

Q9Y485
GTQDLGLRFDAHGSL

DISP2

886

A7MBM2
DSSAQLSSGEHLLGP

ATP10B

1416

O94823
VLGGDHSLAIGSISG

ARG1

96

P05089
LISLATGHREEGGEN

ANXA6

501

P08133
HVSTGGGASLELLEG

PGK2

391

P07205
GIDLGSTGDTTEALH

R3HCC1L

506

Q7Z5L2
QADGLSLGGSHLRVS

RAVER1

281

Q8IY67
LELSGGGDVATLELH

RBPJL

391

Q9UBG7
LADGIDTSGGGSIHV

NR2C2

331

P49116
SATLGGLLQDHGSRL

PTPRN2

396

Q92932
DIDIQATDGGGLSAH

PCDHB1

316

Q9Y5F3
TGGSLLEDLASGLEH

MBD3L1

101

Q8WWY6
SILDLVDDHHGSTGG

PDGFRA

416

P16234
ELGRGTSTHDGIAIA

MSH3

976

P20585
VNVSLEGGEGHFALS

DCHS1

401

Q96JQ0
GHVASVDSVLLLQGG

FBXW9

171

Q5XUX1
GASILDLHSGALSVG

OGFOD3

141

Q6PK18
GDLVLHINGESTQGL

MAGIX

171

Q9H6Y5
AGGLIHLDALDGKSN

MAP7D2

621

Q96T17
GHNLISLLEVLSGDT

DST

66

Q03001
NLTESGVHGALLALD

PPFIA3

1061

O75145
IIGHIASLASGVGNE

ATP12A

281

P54707
LSSAAGDITLGSVHG

FAM185A

251

Q8N0U4
GDITLGSVHGNITLQ

FAM185A

256

Q8N0U4
SLGEVGHHIDLSGQL

CAND1

841

Q86VP6
GHGSILEENVLLGSG

EIF2B5

351

Q13144
TVGELSRALGHENGS

MOAP1

116

Q96BY2
RDSKDHTVSGNGLGI

PCLO

4501

Q9Y6V0
GGASLNLSLTAEHSG

FCRL5

801

Q96RD9
GGSGESILVSQLQHG

INTS2

111

Q9H0H0
LLGSHGQELLIEGTS

LRBA

1826

P50851
THRLLDLGAGDGEVT

METTL9

146

Q9H1A3
LDGELGGQTLEHSTV

TUBGCP2

771

Q9BSJ2
LGAHRGGSGELLENT

GDPD3

41

Q7L5L3
SLQLGLSHEVTEAGG

ABCC2

1421

Q92887
LSHEVTEAGGNLSIG

ABCC2

1426

Q92887
HLDLVEGSLLQGTEG

F8

1536

P00451
HVSTGGGASLELLEG

PGK1

391

P00558
GGASGEALLTHLLSD

PELP1

451

Q8IZL8
GVGKGDLQSTLLEGH

HAUS8

81

Q9BT25
LSGSDLGGHSSLLER

PCNT

2476

O95613
TEISGDLSGHTSQLG

ACAN

2196

P16112
NSIEVAGLSHGLEGL

PTPN21

636

Q16825
GGSHSALLTQDGLLF

HERC5

251

Q9UII4
DGNHTALTGFILLGL

OR5P2

6

Q8WZ92
SAHDSTLLALQGALG

ACP4

286

Q9BZG2
SRSGQGGTLHAVIDE

ERVK-5

256

Q9HDB9
SHTSVGNILGSLIAG

SLC37A2

186

Q8TED4
EVLGHFGVNESTGLS

ATP2A2

11

P16615
IGPQHQAGSDSLLTG

CNOT7

221

Q9UIV1
QSLVSLLDVEHLGGA

HEATR3

471

Q7Z4Q2
NGSDDALGVLITHGT

BOC

76

Q9BWV1
LLQHGASLLGSAGAE

BTAF1

111

O14981
THVGGLGLNLTGADT

BTAF1

1706

O14981
GHVLSGRTALQIGDS

DEAF1

126

O75398
SLGHVESGLEDVLGN

ANKMY1

441

Q9P2S6
GLLSLQVLHEETSGC

EDDM13

81

A0A1B0GTR0
SLHDGSDGLDGISVG

LURAP1L

166

Q8IV03
LEDGGSAHGVFLLNS

GAA

301

P10253
TLIGENGHSTDTLTG

LTBP3

91

Q9NS15
SLGEHGFLNLKSSGL

EPHX3

71

Q9H6B9
IISRESHGGSVLQDG

LYG2

101

Q86SG7
GLRAGDLITHINGES

MAST3

996

O60307
GVEGGHSLDNSLSIL

DPEP2

186

Q9H4A9
IGRQHQAGSDSLLTG

CNOT8

221

Q9UFF9
GHSDVADNGTLFLGI

IFNG

41

P01579
GQLTHLEAELVSGGV

CCDC170

406

Q8IYT3
THAGLNIVTGDDFGL

EML6

1891

Q6ZMW3
DSEGQLRLVGSGLHT

EMILIN1

506

Q9Y6C2
SHGLELLAGEGKLSG

EVC

401

P57679
CLIGVEGGHSLDSSL

DPEP3

191

Q9H4B8
LAEGVSASLHTLLGD

HDAC6

391

Q9UBN7
LVLVEGAHSDAGSQG

DVL1P1

81

P54792
SLIGVEGGHSIDSSL

DPEP1

136

P16444
EGGHSIDSSLGVLRA

DPEP1

141

P16444
GLAVGTLSGDALLHL

SLC39A12

406

Q504Y0
GEAAGSSLIGHLQTL

DUSP5

331

Q16690
LGGVNSLGVSSLEHI

PEX1

556

O43933
AGLDGLHSSNEVLAG

LGSN

426

Q5TDP6
QLLDTDGGFVHSDGA

PAFAH1B2

171

P68402
SNLRDGVSHLIQSGG

SLC12A5

771

Q9H2X9
ETEALGLARSHGEQG

NR5A2

46

O00482
GLGSALLSSLGEHAF

GRIN3B

841

O60391
SAGNLLTHVGHTILG

UTY

1061

O14607
GEALSGHRATVNGTL

UVRAG

586

Q9P2Y5
GSQLDIHSGGIDLAF

CARS2

266

Q9HA77
DLGCGNGLLVHILSS

TRMT44

361

Q8IYL2
QASTLLGLLLGDHTE

SMIM34

16

A8MWV9
LGLLLGDHTEGRNDT

SMIM34

21

A8MWV9
GLAGLAEGSLHASSQ

SSPOP

2071

A2VEC9
RTLTHSISDGQLQGG

TAB2

101

Q9NYJ8
AHENGFEEGLSTLGL

SLC18B1

361

Q6NT16
NGSHLGSLRDLGTSL

LRRC56

101

Q8IYG6
GSLRDLGTSLGHLQV

LRRC56

106

Q8IYG6
SIRSLQTGVGELHGE

PLD1

626

Q13393
ASILGGSHSEGLLQI

SMAD4

226

Q13485
GSHSEGLLQIASGPQ

SMAD4

231

Q13485
SGLGGSQLIDTHLLQ

PRRC2C

2531

Q9Y520
SLDLGLKQAAGSGHL

SHBG

251

P04278
SAGLELSAGTEGLLE

SIX5

666

Q8N196
GHLGTVDFLLAQGAS

TANC2

1111

Q9HCD6
GDLLGTGLLALSFHV

SLC41A1

486

Q8IVJ1
LGDLLGSSSVGHTAA

SLC41A3

451

Q96GZ6
HAILVSDGGELRIGS

PKHD1

1986

P08F94
LDLTGAVGHHGDNLV

SCFD2

276

Q8WU76
AGTSTGGILALAILH

PLA2G6

516

O60733
TFGDVGLLTGDVQLH

SKIV2L

376

Q15477
ELNVGGEFHTTTLGT

KCTD14

36

Q9BQ13
SHRSLIVAGLGDGSI

RPTOR

1176

Q8N122
LSDHLNAEIAGGTIT

ASCC3

1731

Q8N3C0
LAGLGGSEQGTVTAH

CHRD

571

Q9H2X0
ALQALSEGHGVSLGS

NCOA2

536

Q15596
VTSLLHLGGGDDSDG

INPP5J

441

Q15735
TEDGNLASTLGQHKG

TBL1X

316

O60907
LNGDGTGRGTHLSLF

TRAF2

396

Q12933
DLAHTGISSGLIAGS

UBN2

846

Q6ZU65
GDLIFQDGHLISGSL

RASGEF1A

36

Q8N9B8
ENSGLGISLEATVGH

MPDZ

561

O75970
ILDKASGGSLQGHDA

NGDN

71

Q8NEJ9
SDTLIHLDGDGGFSV

SSH2

146

Q76I76
ALQITVGHILGDAGS

SPNS3

406

Q6ZMD2
GLHSLSALEQLEDGG

RP1L1

86

Q8IWN7
DVRGGSGDILLVHAT

RAPGEF1

691

Q13905
SALHRIIGGTDTLEG

TMPRSS7

601

Q7RTY8
VAFHGLSLGLSLTNG

PSD2

66

Q9BQI7
SGHDVSDGGLVTCLL

PFAS

906

O15067
LIEGHTIGIGDSIAD

POLR2A

681

P24928
KQGEGSSGVSSLLLH

ZC3H11A

231

O75152
SGNGVIHLLDLKSGE

SPAG16

581

Q8N0X2
DGNLLSIVTSGGAHG

TPP2

251

P29144
GGLQEVEALSGSVHS

TSSC4

276

Q9Y5U2
GEGGSHGVIQDLSIL

ZNF281

166

Q9Y2X9
GSSLAGVASGRLHLE

SNX19

66

Q92543
LGTQHGEGNSALSPL

SYMPK

926

Q92797
EQGEGSSGVSSLLLH

ZC3H11B

231

A0A1B0GTU1
ETLLNGVGYLHEGLS

SNRNP200

1611

O75643
DGLGTGDGLHSQVLQ

ZNF80

6

P51504
SLEGEGLGTDDGLHS

ZNF550

156

Q7Z398
GLGTDDGLHSRALQE

ZNF550

161

Q7Z398
GTASALLHIDESAGL

ZFX

376

P17010
LISGDGLVTLSGLSH

STRADB

191

Q9C0K7
GDLGVHSGEELQLTT

WLS

506

Q5T9L3
GQLLGDDTQTLGSLH

TMUB1

146

Q9BVT8
GHTEGGELVNELLKS

ZNF557

16

Q8N988
GVSQELFSAGLVDGH

STK39

481

Q9UEW8
ADTGGGGRESNIHLI

UBR4

4976

Q5T4S7
AGLGGLTHLSLASLQ

TSKU

226

Q8WUA8
RGLGHTGGTLDKLES

TYMP

146

P19971
GDSGELITAAHELGV

TMEM260

51

Q9NX78
GIQEINVSLTGLGHS

ZNF518B

706

Q9C0D4
VHGGLLVLGSANVDE

NADSYN1

506

Q6IA69