Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN5A SCN10A	8.44e-05	6	48	2	GO:0086006
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	SCRT2 ZBTB34 MLXIPL HBP1 IKZF1	9.97e-04	320	48	5	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	SCRT2 ZBTB34 MLXIPL HBP1 IKZF1	1.08e-03	326	48	5	GO:0001217
GeneOntologyMolecularFunction	ankyrin binding	SCN5A IQCJ-SCHIP1	1.39e-03	23	48	2	GO:0030506
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN5A SCN10A	1.77e-03	26	48	2	GO:0005248
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5D JMJD1C	2.06e-03	28	48	2	GO:0141052
GeneOntologyMolecularFunction	histone modifying activity	RPS6KA5 KDM5D TAF1L JMJD1C	2.21e-03	229	48	4	GO:0140993
GeneOntologyMolecularFunction	histone demethylase activity	KDM5D JMJD1C	2.52e-03	31	48	2	GO:0032452
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	MLXIPL PDCD11 SRY KDM5D TAF1L JMJD1C	2.59e-03	582	48	6	GO:0140297
GeneOntologyMolecularFunction	protein demethylase activity	KDM5D JMJD1C	2.68e-03	32	48	2	GO:0140457
GeneOntologyBiologicalProcess	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	5.76e-06	2	50	2	GO:0021816
GeneOntologyBiologicalProcess	cerebral cortex radial glia-guided migration	SRGAP2C RTN4 SRGAP2	5.20e-05	30	50	3	GO:0021801
GeneOntologyBiologicalProcess	telencephalon glial cell migration	SRGAP2C RTN4 SRGAP2	5.20e-05	30	50	3	GO:0022030
GeneOntologyBiologicalProcess	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	5.73e-05	5	50	2	GO:0021815
GeneOntologyBiologicalProcess	cell motility involved in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	1.20e-04	7	50	2	GO:0021814
GeneOntologyBiologicalProcess	bundle of His cell action potential	SCN5A SCN10A	1.20e-04	7	50	2	GO:0086043
GeneOntologyBiologicalProcess	bundle of His cell to Purkinje myocyte signaling	SCN5A SCN10A	1.20e-04	7	50	2	GO:0086028
GeneOntologyBiologicalProcess	cerebral cortex radially oriented cell migration	SRGAP2C RTN4 SRGAP2	1.44e-04	42	50	3	GO:0021799
GeneOntologyBiologicalProcess	regulation of atrial cardiac muscle cell membrane depolarization	SCN5A SCN10A	2.56e-04	10	50	2	GO:0060371
MousePheno	increased B-1 B cell number	FNIP1 IKZF1 CCR6 DICER1	1.52e-05	59	36	4	MP:0004977
MousePheno	increased mature B cell number	EPS15 FNIP1 IKZF1 CCR6 DICER1	6.59e-05	168	36	5	MP:0008210
Domain	Peptidase_M43	PAPPA2 PAPPA	6.20e-06	2	47	2	IPR008754
Domain	Peptidase_M43	PAPPA2 PAPPA	6.20e-06	2	47	2	PF05572
Domain	srGAP2	SRGAP2C SRGAP2	1.86e-05	3	47	2	IPR030252
Domain	Myxo_disulph_rpt	PAPPA2 PAPPA	1.86e-05	3	47	2	IPR011936
Domain	LamGL	PAPPA2 PAPPA	3.71e-05	4	47	2	SM00560
Domain	LamG-like	PAPPA2 PAPPA	3.71e-05	4	47	2	IPR006558
Domain	Notch_dom	PAPPA2 PAPPA	1.29e-04	7	47	2	IPR000800
Domain	Notch	PAPPA2 PAPPA	1.29e-04	7	47	2	PF00066
Domain	NL	PAPPA2 PAPPA	1.29e-04	7	47	2	SM00004
Domain	Na_channel_asu	SCN5A SCN10A	2.75e-04	10	47	2	IPR001696
Domain	Na_trans_assoc	SCN5A SCN10A	2.75e-04	10	47	2	IPR010526
Domain	Na_trans_assoc	SCN5A SCN10A	2.75e-04	10	47	2	PF06512
Domain	FCH	SRGAP2C SRGAP2	1.39e-03	22	47	2	PF00611
Domain	FCH	SRGAP2C SRGAP2	1.39e-03	22	47	2	SM00055
Domain	FCH_dom	SRGAP2C SRGAP2	1.52e-03	23	47	2	IPR001060
Domain	JmjC	KDM5D JMJD1C	1.65e-03	24	47	2	PF02373
Domain	-	PAPPA2 FAT3 PAPPA	1.76e-03	95	47	3	2.60.120.200
Domain	F_BAR	SRGAP2C SRGAP2	1.79e-03	25	47	2	IPR031160
Domain	F_BAR	SRGAP2C SRGAP2	1.79e-03	25	47	2	PS51741
Domain	VWC	VWF ECM2	2.25e-03	28	47	2	PF00093
Domain	JMJC	KDM5D JMJD1C	2.93e-03	32	47	2	PS51184
Domain	JmjC_dom	KDM5D JMJD1C	2.93e-03	32	47	2	IPR003347
Domain	JmjC	KDM5D JMJD1C	3.11e-03	33	47	2	SM00558
Domain	VWFC_1	VWF ECM2	3.70e-03	36	47	2	PS01208
Domain	VWC	VWF ECM2	4.11e-03	38	47	2	SM00214
Domain	VWFC_2	VWF ECM2	4.11e-03	38	47	2	PS50184
Domain	VWF_dom	VWF ECM2	5.01e-03	42	47	2	IPR001007
Domain	Sushi	PAPPA2 PAPPA	7.59e-03	52	47	2	PF00084
Domain	HMG_box	HBP1 SRY	7.87e-03	53	47	2	PF00505
Domain	HMG_BOX_2	HBP1 SRY	8.16e-03	54	47	2	PS50118
Domain	HMG	HBP1 SRY	8.16e-03	54	47	2	SM00398
Domain	CCP	PAPPA2 PAPPA	8.16e-03	54	47	2	SM00032
Domain	-	HBP1 SRY	8.46e-03	55	47	2	1.10.30.10
Domain	SUSHI	PAPPA2 PAPPA	8.75e-03	56	47	2	PS50923
Domain	Sushi_SCR_CCP_dom	PAPPA2 PAPPA	9.06e-03	57	47	2	IPR000436
Domain	Channel_four-helix_dom	SCN5A SCN10A	9.06e-03	57	47	2	IPR027359
Domain	-	SCN5A SCN10A	9.06e-03	57	47	2	1.20.120.350
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	VPS13D AFAP1 RGPD1 FNIP1 CLASP2 DICER1	5.59e-07	209	50	6	36779422
Pubmed	A common genetic variant within SCN10A modulates cardiac SCN5A expression.	SCN5A SCN10A	2.03e-06	2	50	2	24642470
Pubmed	The murine situs inversus viscerum (iv) gene responsible for visceral asymmetry is linked tightly to the Igh-C cluster on chromosome 12.	SRY DNAH11	2.03e-06	2	50	2	2365357
Pubmed	Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.	SCN5A SCN10A	2.03e-06	2	50	2	15047701
Pubmed	SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.	SRGAP2C SRGAP2	2.03e-06	2	50	2	27373832
Pubmed	Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.	PAPPA2 PAPPA	2.03e-06	2	50	2	21586553
Pubmed	Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.	SCN10A DICER1	2.03e-06	2	50	2	20702715
Pubmed	Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.	SCN5A SCN10A	2.03e-06	2	50	2	31292628
Pubmed	Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.	PAPPA2 PAPPA	2.03e-06	2	50	2	29144175
Pubmed	Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.	SCN5A SCN10A	2.03e-06	2	50	2	24998131
Pubmed	From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.	SCN5A SCN10A	2.03e-06	2	50	2	24360055
Pubmed	Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.	PAPPA2 PAPPA	2.03e-06	2	50	2	11513734
Pubmed	Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.	SCN5A SCN10A	2.03e-06	2	50	2	32330377
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2C SRGAP2	6.07e-06	3	50	2	22559944
Pubmed	Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR.	PAPPA2 PAPPA	6.07e-06	3	50	2	29532882
Pubmed	Altered placental expression of PAPPA2 does not affect birth weight in mice.	PAPPA2 PAPPA	6.07e-06	3	50	2	20642865
Pubmed	Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.	SCN5A CLASP2	6.07e-06	3	50	2	34092082
Pubmed	High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.	SCN5A SCN10A	6.07e-06	3	50	2	25998140
Pubmed	Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.	PAPPA2 PAPPA	6.07e-06	3	50	2	18805800
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2C SRGAP2	1.21e-05	4	50	2	22559943
Pubmed	Molecular analysis of an isoYq chromosome in a sterile male mouse.	SRY KDM5D	1.21e-05	4	50	2	8678984
Pubmed	Genome-wide association studies of the PR interval in African Americans.	SCN5A SCN10A	1.21e-05	4	50	2	21347284
Pubmed	Discovery and refinement of loci associated with lipid levels.	MLXIPL IKZF1 CUBN JMJD1C DNAH11	1.33e-05	211	50	5	24097068
Pubmed	Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.	SCN5A SCN10A	2.02e-05	5	50	2	22706305
Pubmed	Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.	SCN5A SCN10A	2.02e-05	5	50	2	23463857
Pubmed	Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.	SCN5A SCN10A	2.02e-05	5	50	2	23872634
Pubmed	Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.	SCN5A SCN10A	4.23e-05	7	50	2	23139255
Pubmed	Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal.	SRY KDM5D	5.64e-05	8	50	2	7479793
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN5A SCN10A	7.25e-05	9	50	2	16382098
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RTN4 RGPD1	1.10e-04	11	50	2	35771867
Pubmed	Genome-wide association study of PR interval.	SCN5A SCN10A	1.32e-04	12	50	2	20062060
Pubmed	The role of Dby mRNA in early development of male mouse zygotes.	SRY KDM5D	1.32e-04	12	50	2	20543856
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	SRY KDM5D	1.56e-04	13	50	2	14660691
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN5A SCN10A	1.56e-04	13	50	2	15123669
Pubmed	Several common variants modulate heart rate, PR interval and QRS duration.	SCN5A SCN10A	1.82e-04	14	50	2	20062063
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PLEKHG1 MLXIPL VPS13D PI4KA FNIP1 CLASP2 SRGAP2	2.20e-04	861	50	7	36931259
Pubmed	Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.	SCN5A SCN10A	2.40e-04	16	50	2	25035420
Pubmed	Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.	SCN5A SCN10A	2.72e-04	17	50	2	21076409
Pubmed	Genetic determinants of P wave duration and PR segment.	SCN5A SCN10A	2.72e-04	17	50	2	24850809
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	SRY KDM5D	3.05e-04	18	50	2	12023983
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN5A SCN10A	3.05e-04	18	50	2	31666509
Pubmed	Brugada Syndrome	SCN5A SCN10A	5.48e-04	24	50	2	20301690
Pubmed	An integrative method for scoring candidate genes from association studies: application to warfarin dosing.	VWF DICER1	6.95e-04	27	50	2	21044367
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	VPS13D PI4KA RTN4 FNIP1 CHML	7.76e-04	504	50	5	34432599
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	SCN5A SCN10A	8.59e-04	30	50	2	39366945
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MLXIPL AFAP1 VWF PI4KA RTN4 CLASP2 SRGAP2 DNAH11	9.27e-04	1431	50	8	37142655
Pubmed	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	MLXIPL DNAH11	1.10e-03	34	50	2	19060911
Pubmed	Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.	IQCJ-SCHIP1 CUBN	1.10e-03	34	50	2	19197348
Pubmed	MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.	PAPPA2 PAPPA	1.17e-03	35	50	2	22407321
Pubmed	Biological, clinical and population relevance of 95 loci for blood lipids.	MLXIPL JMJD1C DNAH11	1.23e-03	146	50	3	20686565
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EPS15 AFAP1 PI4KA PDCD11 CLASP2 SRGAP2 TAF1L DICER1	1.24e-03	1497	50	8	31527615
Pubmed	Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.	SCN10A IKZF1	1.38e-03	38	50	2	23273568
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	SCN5A SCN10A CLASP2	1.08e-03	184	50	3	chr3p22
GeneFamily	Pappalysins\|Sushi domain containing	PAPPA2 PAPPA	2.85e-06	2	31	2	897
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN5A SCN10A	1.02e-04	9	31	2	1203
GeneFamily	X-linked mental retardation\|RNA helicases	HELQ DICER1	1.55e-04	11	31	2	1168
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2C SRGAP2	7.04e-04	23	31	2	1288
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5D JMJD1C	7.67e-04	24	31	2	485
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	PDCD11 KDM5D	3.44e-03	51	31	2	870
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAPPA2 PAPPA	4.28e-03	57	31	2	1179
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG1 AFAP1 SKAP1	5.18e-03	206	31	3	682
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB34 KLHL4	2.20e-02	134	31	2	861
Coexpression	ALONSO_METASTASIS_DN	EPS15 RGPD1 PAPPA	1.55e-05	26	49	3	M17331
ToppCell	distal-3-mesenchymal-Myofibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PAPPA2 C14orf132 ECM2 PAPPA SYNDIG1	2.90e-06	199	50	5	1f20addc0d138fec02ed6ca4c518169c568de263
ToppCell	distal-mesenchymal-Myofibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PAPPA2 C14orf132 ECM2 PAPPA SYNDIG1	2.97e-06	200	50	5	069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCell	distal-mesenchymal-Myofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PAPPA2 C14orf132 ECM2 PAPPA SYNDIG1	2.97e-06	200	50	5	61854a459385cd9295be37157a8f81a2c227dff3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MLXIPL SRGAP2C RPS6KA5 SYNDIG1	2.49e-05	151	50	4	2f9b3e14c2fa6e2b1976ca6ab2031b63bf5e3e64
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-microglial_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MLXIPL SRGAP2C SYNDIG1 SRGAP2	2.90e-05	157	50	4	d4908cafd8870c1c225817f589ea2bce116ac7ab
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 SESTD1 CLASP2 JMJD1C	3.36e-05	163	50	4	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLEKHG1 SKAP1 IKZF1 CCR6	3.52e-05	165	50	4	0c80abf13409767825ef8a507b498afafa7e89c5
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLEKHG1 SKAP1 IKZF1 CCR6	3.52e-05	165	50	4	cced77f2d74b07010307d7f4788b8cf3fdaeb91a
ToppCell	E16.5-Endothelial-Endothelial_lymphatic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SKAP1 SCN5A KLHL4	3.69e-05	167	50	4	b93103a868fba63a8910bffb690a6242b9252833
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SKAP1 SCN5A KLHL4	3.69e-05	167	50	4	fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SKAP1 SCN5A KLHL4	3.69e-05	167	50	4	f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MLXIPL SRGAP2C SYNDIG1 SRGAP2	3.69e-05	167	50	4	942134bbabe9972fae80cbc4ed4e94da52f55dc3
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SKAP1 SCN5A KLHL4	3.69e-05	167	50	4	26cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA12 FAT3 CUBN DNAH11	3.87e-05	169	50	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG1 EPS15 ECM2 DNAH11	3.96e-05	170	50	4	513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF KDM5D DICER1 KLHL4	4.14e-05	172	50	4	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF KDM5D DICER1 KLHL4	4.14e-05	172	50	4	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 SESTD1 CLASP2 JMJD1C	4.24e-05	173	50	4	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA5 PAPPA SYNDIG1 CLASP2	5.16e-05	182	50	4	6fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCell	343B-Fibroblasts-Fibroblast-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SESTD1 ECM2 PAPPA SYNDIG1	5.61e-05	186	50	4	1bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell	343B-Fibroblasts-Fibroblast-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	SESTD1 ECM2 PAPPA SYNDIG1	5.61e-05	186	50	4	59db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell	356C-Endothelial_cells-Endothelial-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG1 VWF CUBN TAF1L	5.61e-05	186	50	4	2e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell	356C-Endothelial_cells-Endothelial-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG1 VWF CUBN TAF1L	5.61e-05	186	50	4	c3449e54454009973818fc1101933c6f0168258c
ToppCell	COVID-19-kidney-T-cells-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RPS6KA5 SKAP1 IKZF1 CCR6	5.85e-05	188	50	4	15484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 CLASP2 SRGAP2 JMJD1C	5.97e-05	189	50	4	6dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 C14orf132 SESTD1 SKAP1	5.97e-05	189	50	4	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 CLASP2 SRGAP2 JMJD1C	5.97e-05	189	50	4	3ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell	facs-Brain_Myeloid-Striatum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 CLASP2 SRGAP2 JMJD1C	5.97e-05	189	50	4	97ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	ECM2 FAT3 CLASP2 KDM5D	6.10e-05	190	50	4	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MLXIPL PAPPA SYNDIG1 CUBN	6.22e-05	191	50	4	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MLXIPL PAPPA SYNDIG1 CUBN	6.22e-05	191	50	4	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 SESTD1 SKAP1 SYNDIG1	6.22e-05	191	50	4	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 SESTD1 SKAP1 SYNDIG1	6.22e-05	191	50	4	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 PLEKHG1 SESTD1 SKAP1	6.74e-05	195	50	4	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 PLEKHG1 SESTD1 SKAP1	6.74e-05	195	50	4	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PAPPA2 ECM2 PAPPA SYNDIG1	7.01e-05	197	50	4	16758f181ef07c60aee63072e1da9572c5c85414
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PAPPA2 ECM2 PAPPA SYNDIG1	7.15e-05	198	50	4	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	medial-Hematologic-CD4+_Naive_T-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	OTUD6A RGPD1 IKZF1 CCR6	7.29e-05	199	50	4	6a896a447388fd525cff207e17a5371c0f6b38cb
ToppCell	medial-2-Hematologic-CD4+_Naive_T\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	OTUD6A RGPD1 IKZF1 CCR6	7.29e-05	199	50	4	231a539899e2b76215da3e96a6755799f722e278
ToppCell	distal-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PAPPA2 ECM2 PAPPA SYNDIG1	7.29e-05	199	50	4	b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCell	medial-Hematologic-CD4+_Naive_T\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	OTUD6A RGPD1 IKZF1 CCR6	7.29e-05	199	50	4	a54c35a646ae23bdd35c278ffb027408cf8dd553
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C SYNDIG1 IKZF1 SRGAP2	7.44e-05	200	50	4	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C SYNDIG1 IKZF1 SRGAP2	7.44e-05	200	50	4	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C SYNDIG1 IKZF1 SRGAP2	7.44e-05	200	50	4	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C SYNDIG1 IKZF1 SRGAP2	7.44e-05	200	50	4	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PAPPA2 ECM2 PAPPA SYNDIG1	7.44e-05	200	50	4	b441b3771fb7d9ee7b7a104afc35e466aace2da2
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C SYNDIG1 IKZF1 SRGAP2	7.44e-05	200	50	4	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C SYNDIG1 IKZF1 SRGAP2	7.44e-05	200	50	4	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MLXIPL CCR6 NAP1L6P	1.66e-04	95	50	3	3d6b97576ce4e7a3e495cbc7246ea8c0b2a386f7
ToppCell	facs-Aorta-Heart-3m-Endothelial-coronary_vascular_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRT2 FAT3 KLHL4	4.37e-04	132	50	3	dc13b54e38fbda9341972cef11833041f2f2a345
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MLXIPL SRGAP2C RPS6KA5	4.67e-04	135	50	3	9f9d0787a2e99207a9caa88a85565189ab8b940a
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Crh\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 SKAP1 SCN10A	4.77e-04	136	50	3	44f03e4f55fb2c5f8b9397142c89f7194b009cc6
ToppCell	LPS-IL1RA-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	4.98e-04	138	50	3	10c263c58b83a018791f77098f18927d904cb13b
ToppCell	PND07-28-samps-Lymphocyte-T_cells-T_cells_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SKAP1 CCR6 KDM5D	4.98e-04	138	50	3	221a964e86d7d3406cdb7573899155fee8d33abd
ToppCell	LPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 SCN10A IKZF1	5.09e-04	139	50	3	ecc2a6ecc27748c50885cd4f0ad8a8cd1252aee6
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-MPP_myeloid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MLXIPL CUBN NAP1L6P	5.19e-04	140	50	3	eb1d22f5f5dbf60b6485464baec4be9b3060f65c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 SKAP1 SCN10A	5.30e-04	141	50	3	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	Control-Hematopoietic_Mast-Mast_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.41e-04	142	50	3	a81f7ea4516a869c7c9b9a3f4ef74844ff9fffcd
ToppCell	Control-Hematopoietic_Mast-Mast_cells-T-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.41e-04	142	50	3	70f8c1be134835e0d21e6d426b7122f0f5d3d3e5
ToppCell	LPS-IL1RA-Hematopoietic_Mast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.41e-04	142	50	3	f7d0d5ca9fc3dd929d4fdd59b71bfa623007e992
ToppCell	Control-Hematopoietic_Mast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.41e-04	142	50	3	db9b7acbab730ae391a362f1ca8177507e52250d
ToppCell	LPS-IL1RA-Hematopoietic_Mast-Mast_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.41e-04	142	50	3	2a9a070e7c53ac593d46c6c5f6983f07d4413501
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLEKHG1 VWF FNIP1	5.64e-04	144	50	3	f501e11b1d051ca67124137017a79a2d5bb6ae87
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.87e-04	146	50	3	a5c84ad44d6ffb25028a4fd5454fd5de81b16a5e
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.87e-04	146	50	3	8133037881c15e75637fc616091a7055488dd5fc
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAT3 SKAP1 CCR6	5.87e-04	146	50	3	159dd157a74f3c27dc1a1dcbbf0ed8f9462cac9e
ToppCell	LPS-antiTNF-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	5.98e-04	147	50	3	1ecd7c084e73eb6fae1ab1f9aae17115d3d62cbd
ToppCell	LPS-antiTNF-Hematopoietic_Mast-Mast_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	6.22e-04	149	50	3	59aa1f2a5cbeba64c4529fb05f544db17fd8b188
ToppCell	LPS-antiTNF-Hematopoietic_Mast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	6.22e-04	149	50	3	1527cdd98a2734cbf8ce4c6170557280b71c55cb
ToppCell	LPS_only-Hematopoietic_Mast-Mast_cells-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	6.35e-04	150	50	3	ccb782fbcb3122266354a112a9a850506664f44d
ToppCell	LPS_only-Hematopoietic_Mast-Mast_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	6.35e-04	150	50	3	7290e9a812b1b2f919e67ccde0acf52687ab138f
ToppCell	LPS_only-Hematopoietic_Mast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	6.35e-04	150	50	3	2c5078a1f769ba8153dee756b53d28eb7b434a96
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	SKAP1 CCR6 HELQ	6.47e-04	151	50	3	72c47ed207951e73ef6c72085b2a3f48a99be952
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SKAP1 IKZF1 CCR6	6.47e-04	151	50	3	b85a763459a0f019d1f9975d09b9f2247d62c9d3
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	AFAP1 VWF ZMYM6	6.85e-04	154	50	3	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	facs-Spleen-nan-18m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRT2 SKAP1 KLHL4	7.24e-04	157	50	3	a84377028c661f8f3ecae0f6082abdd859faf0c8
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tregs\|Lung / Manually curated celltypes from each tissue	ECM2 SKAP1 CCR6	7.38e-04	158	50	3	f433bc189f000efa34e8e09ab32b3fa22bcf64c4
ToppCell	Adult-Immune-mast_cell-D175\|Adult / Lineage, Cell type, age group and donor	PAPPA2 SKAP1 IKZF1	7.51e-04	159	50	3	9f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-microglial_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MLXIPL SYNDIG1 SRGAP2	7.51e-04	159	50	3	31ec8222c766cb614e1cf27f74ee9d99489eca5c
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS13D SKAP1 IKZF1	7.65e-04	160	50	3	b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS13D SKAP1 IKZF1	7.65e-04	160	50	3	9caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCell	normal_Lung-T/NK_cells-Naive_CD8+_T\|normal_Lung / Location, Cell class and cell subclass	CEP72 SKAP1 HELQ	7.65e-04	160	50	3	97a4c69824e8708fbb12c468be1828d24a111db3
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS13D SKAP1 IKZF1	7.65e-04	160	50	3	229841be7b984a00a301cd5d88c11226a90d8a88
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS13D SKAP1 IKZF1	7.65e-04	160	50	3	99c9ae2041445539fada842e1af01368669bfca0
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SCN5A KLHL4	7.79e-04	161	50	3	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SCN5A KLHL4	7.79e-04	161	50	3	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SCN5A KLHL4	7.79e-04	161	50	3	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	COVID-19_Severe-Treg\|World / disease group, cell group and cell class	RPS6KA5 SKAP1 CCR6	7.79e-04	161	50	3	c6eade2c60c572d823e6e81b5e8d47078671e9b0
ToppCell	facs-Aorta-Heart-18m-Myeloid-professional_antigen_presenting_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SKAP1 IKZF1 CCR6	7.93e-04	162	50	3	a6c6b953156c2e393d6ef5c3228eae90c472dda6
ToppCell	human_hepatoblastoma-Tumor_cells-T7\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FAT3 SCN10A IKZF1	7.93e-04	162	50	3	c6ace47daf32495b25793d39b72382978349597d
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECM2 SCN5A KLHL4	7.93e-04	162	50	3	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45____NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA5 SKAP1 IKZF1	8.07e-04	163	50	3	a763c1632d6465a1e753bdc8eadaf819d2b09e5e
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA5 SKAP1 IKZF1	8.07e-04	163	50	3	eaed783eecd07aafa5af844b63c9d816b4da99e4
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IKZF1 CCDC180 KLHL4	8.07e-04	163	50	3	c21114826bee1b05b411984326fef6b6e0d05316
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SRY DNAH11 KLHL4	8.07e-04	163	50	3	1e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCell	facs-Aorta-Heart-18m-Myeloid\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SKAP1 IKZF1 CCR6	8.07e-04	163	50	3	ae9dd2daf06ad0b78f666617f6b070ec3ecc13d8
ToppCell	facs-Aorta-Heart-18m-Myeloid-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SKAP1 IKZF1 CCR6	8.07e-04	163	50	3	ee94242a048fc62b85be85eca2442e13553cbfb7
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IKZF1 CCDC180 KLHL4	8.07e-04	163	50	3	5d49414432db259a19df50d7944581d00b69f537
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D231\|Adult / Lineage, Cell type, age group and donor	ECM2 PAPPA SYNDIG1	8.22e-04	164	50	3	3d8ff70fe5582d1fb56b338be8b76fa1428b3657
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM198 SKAP1 IKZF1	8.22e-04	164	50	3	1a9b444d2c6abcc83d4355ec5228b27541df2bd0
Drug	Hexylcaine	SCN5A SCN10A	4.54e-06	2	49	2	DB00473
Disease	Brugada ECG Pattern	SCN5A SCN10A	1.55e-05	4	48	2	C1721096
Disease	whole-brain volume	CUBN DNAH11	2.58e-05	5	48	2	EFO_0005089
Disease	brain measurement, neuroimaging measurement	ZBTB34 AFAP1 FAT3 RGPD1 PAPPA IQCJ-SCHIP1 DNAH11	2.86e-05	550	48	7	EFO_0004346, EFO_0004464
Disease	neuroimaging measurement	PLEKHG1 MLXIPL AFAP1 FAT3 RGPD1 PAPPA IQCJ-SCHIP1 JMJD1C DNAH11	4.88e-05	1069	48	9	EFO_0004346
Disease	electrocardiography, PR interval	SCN5A SCN10A	5.41e-05	7	48	2	EFO_0004327, EFO_0004462
Disease	supraventricular ectopy	SCN5A SCN10A	9.26e-05	9	48	2	EFO_0009277
Disease	neuroimaging measurement, brain volume measurement	AFAP1 FAT3 RGPD1 PAPPA IQCJ-SCHIP1	1.01e-04	286	48	5	EFO_0004346, EFO_0006930
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN5A SCN10A	1.16e-04	10	48	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN5A SCN10A	1.16e-04	10	48	2	DOID:0080422 (implicated_via_orthology)
Disease	PR interval	EPS15 ABCA12 TMEM198 SCN5A SCN10A DNAH11	1.46e-04	495	48	6	EFO_0004462
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN5A SCN10A	1.69e-04	12	48	2	DOID:0060170 (implicated_via_orthology)
Disease	alcohol and nicotine codependence	PLEKHG1 RGPD1	2.00e-04	13	48	2	EFO_0004776
Disease	Brugada Syndrome 1	SCN5A SCN10A	2.00e-04	13	48	2	C4551804
Disease	trimethylamine-N-oxide measurement	RTN4 CUBN	2.33e-04	14	48	2	EFO_0010541
Disease	T wave morphology measurement	SCN5A SCN10A	2.33e-04	14	48	2	EFO_0008398
Disease	Proteinuria	VWF CUBN	2.68e-04	15	48	2	HP_0000093
Disease	P wave duration	SCN5A SCN10A	2.68e-04	15	48	2	EFO_0005094
Disease	Romano-Ward Syndrome	SCN5A SCN10A	3.06e-04	16	48	2	C0035828
Disease	cortical thickness	PLEKHG1 ZBTB34 VPS13D PI4KA FAT3 IQCJ-SCHIP1 SRGAP2 JMJD1C	3.94e-04	1113	48	8	EFO_0004840
Disease	carotid artery disease (is_marker_for)	VWF PAPPA	4.35e-04	19	48	2	DOID:3407 (is_marker_for)
Disease	Brugada syndrome	SCN5A SCN10A	4.35e-04	19	48	2	MONDO_0015263
Disease	Weight Gain	SESTD1 VPS13D DNAH11	6.20e-04	102	48	3	C0043094
Disease	Brugada Syndrome (disorder)	SCN5A SCN10A	6.99e-04	24	48	2	C1142166
Disease	sleep duration, high density lipoprotein cholesterol measurement	MLXIPL AFAP1 JMJD1C	1.02e-03	121	48	3	EFO_0004612, EFO_0005271
Disease	cardiovascular age measurement	SCN5A SCN10A	1.02e-03	29	48	2	EFO_0803380
Disease	cholesteryl esters to total lipids in large LDL percentage	MLXIPL JMJD1C	1.17e-03	31	48	2	EFO_0022249
Disease	heart function measurement	SCN5A SCN10A	1.41e-03	34	48	2	EFO_0004311
Disease	triglyceride measurement, physical activity	MLXIPL JMJD1C	1.41e-03	34	48	2	EFO_0003940, EFO_0004530

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENMYTSPVQDDTTSF	ABCA12	1236	Q86UK0
PEYITSNYDSDAMSS	AFAP1	106	Q8N556
MNFSDVFDSSEDYFV	CCR6	6	P51684
STYDPSDCTNMEFES	DNAH11	521	Q96DT5
YFTPHPDSMDTEDSA	CEP72	296	Q9P209
EDMESFTISSGNTYF	CCDC180	816	Q9P1Z9
SMPFSSDFEDFDYSS	DICER1	1491	Q9UPY3
EESQLSYFNSDEMPA	CHML	141	P26374
NPETSDSFGYDDFMI	OTUD6A	191	Q7L8S5
MDPDNHSYFFEDTLD	MAGEC3	516	Q8TD91
DGFSSPDQYDDEAMS	JMJD1C	1771	Q15652
SFGEMADSFKSDYFN	KDM5D	386	Q9BY66
MEANPSADLYYTSFS	PI4KA	356	P42356
SNFAEEFTEMDPTYS	RPS6KA5	346	O75582
TPYDSSASYEKENEM	IKZF1	291	Q13422
PYNNFMSYADDDCTD	PAPPA	631	Q13219
MSYADDDCTDSFTPN	PAPPA	636	Q13219
SAVSDYFAAMFTNDV	KLHL4	201	Q9C0H6
YMSYTDDNCTDNFTP	PAPPA2	806	Q9BXP8
NTFASPDSDSNGMYD	CUBN	3166	O60494
EEDVFYSDSQSDFMP	CEFIP	706	Q711Q0
HSDPESMSLFDEYFN	FNIP1	826	Q8TF40
AFMDSPNEDFSTEYS	C14orf132	16	Q9NPU4
TFDEPFYNFTVMESD	FAT3	1361	Q8TDW7
NFDYSMEEKFESFSS	ECM2	71	O94769
FDTFKSYDFTPMDSS	HBP1	351	O60381
SNFANFSAYPSEEDM	EPS15	841	P42566
NDSEVDMFGDYDSFT	HELQ	101	Q8TDG4
DMFGDYDSFTENSFI	HELQ	106	Q8TDG4
SASFPMEESSINYTF	RGPD1	1606	P0DJD0
SPQSLMEYSSDADFI	NAP1L6P	26	A6NFF2
EFSELEYSEMGSSFS	RTN4	291	Q9NQC3
AVTDSYSMDAFFISD	SCRT2	101	Q9NQ03
SDYSSDTESEDNFLM	SYNDIG1	161	Q9H7V2
DFSSYSDSESEMGPQ	TAF1L	201	Q8IZX4
ESTEPLSEDDFDMFY	SCN5A	1781	Q14524
DFDVSDCFQYSNSME	SRGAP2C	406	P0DJJ0
FSDSSTPDYREDGMD	IQCJ-SCHIP1	91	B3KU38
PSLDDFMDISDFFTN	MLXIPL	291	Q9NP71
EQYFGSPSDMASTAE	SESTD1	656	Q86VW0
SPSAFDYDTENMNSE	CLASP2	921	O75122
FHMSDSYSETPLEDF	PDCD11	1261	Q14690
LDGSSSFPASYFDEM	VWF	1696	P04275
ESTEPLSEDDFDMFY	SCN10A	1731	Q9Y5Y9
SFSSNFVPSDFMEEL	SPATA31D1	366	Q6ZQQ2
DFDVSDCFQYSNSME	SRGAP2	406	O75044
NDYDMFPSFSEFSNS	ZMYM6	1161	O95789
SAMLSVFNSDDYSPA	SRY	6	Q05066
EDDYQMFVPSFSSSD	PLEKHG1	556	Q9ULL1
TSDAPFLSDYQDEGM	SKAP1	81	Q86WV1
SSFMASPTDADYEYG	TMEM198	331	Q66K66
MDSSSFIQFDVPEYS	ZBTB34	1	Q8NCN2
FFDPTADASCMNTYT	VPS13D	476	Q5THJ4