Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHSY1 CHSY3	1.68e-05	4	34	2	GO:0050510
GeneOntologyMolecularFunction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	CHSY1 CHSY3	4.20e-05	6	34	2	GO:0047238
GeneOntologyMolecularFunction	lipoteichoic acid binding	DMBT1 CD6	5.88e-05	7	34	2	GO:0070891
GeneOntologyMolecularFunction	P-type calcium transporter activity	ATP2A1 ATP2A2	1.53e-04	11	34	2	GO:0005388
GeneOntologyMolecularFunction	ATP hydrolysis activity	HELZ2 KIF12 ATP2A1 ATP2A2 SMC1A	8.43e-04	441	34	5	GO:0016887
GeneOntologyMolecularFunction	lncRNA binding	ATP2A2 NONO	1.62e-03	35	34	2	GO:0106222
GeneOntologyMolecularFunction	glucuronosyltransferase activity	CHSY1 CHSY3	1.62e-03	35	34	2	GO:0015020
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	CHSY1 CHSY3	1.62e-03	35	34	2	GO:0008376
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP2A1 ATP2A2	1.71e-03	36	34	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP2A1 ATP2A2	1.71e-03	36	34	2	GO:0015662
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	HELZ2 KIF12 REM1 ATP2A1 ATP2A2 SMC1A	1.78e-03	775	34	6	GO:0017111
GeneOntologyMolecularFunction	protein tyrosine kinase activity	TEK TESK1 CLK2	1.90e-03	145	34	3	GO:0004713
GeneOntologyMolecularFunction	pyrophosphatase activity	HELZ2 KIF12 REM1 ATP2A1 ATP2A2 SMC1A	2.65e-03	839	34	6	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	HELZ2 KIF12 REM1 ATP2A1 ATP2A2 SMC1A	2.67e-03	840	34	6	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	HELZ2 KIF12 REM1 ATP2A1 ATP2A2 SMC1A	2.67e-03	840	34	6	GO:0016818
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	TESK1 CLK2	2.90e-03	47	34	2	GO:0004712
GeneOntologyMolecularFunction	lipopolysaccharide binding	DMBT1 CD6	3.02e-03	48	34	2	GO:0001530
GeneOntologyMolecularFunction	ATP-dependent activity	HELZ2 KIF12 ATP2A1 ATP2A2 SMC1A	3.60e-03	614	34	5	GO:0140657
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	HELZ2 PPARGC1B	4.84e-03	61	34	2	GO:0030374
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP2A1 ATP2A2	4.99e-03	62	34	2	GO:0019829
GeneOntologyMolecularFunction	N-acetyltransferase activity	GNPNAT1 NAT8L	7.79e-03	78	34	2	GO:0008080
GeneOntologyBiologicalProcess	positive regulation of endoplasmic reticulum calcium ion concentration	ATP2A1 ATP2A2	7.44e-06	3	33	2	GO:0032470
GeneOntologyBiologicalProcess	calcium ion import into sarcoplasmic reticulum	ATP2A1 ATP2A2	5.19e-05	7	33	2	GO:1990036
GeneOntologyCellularComponent	platelet dense tubular network membrane	ATP2A1 ATP2A2	9.18e-05	9	34	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ATP2A1 ATP2A2	1.40e-04	11	34	2	GO:0031094
Domain	P-type_ATPase_IIA	ATP2A1 ATP2A2	8.52e-06	3	32	2	IPR005782
Domain	Chond_GalNAc	CHSY1 CHSY3	7.91e-05	8	32	2	IPR008428
Domain	CHGN	CHSY1 CHSY3	7.91e-05	8	32	2	PF05679
Domain	Hydrolase_3	ATP2A1 ATP2A2	1.27e-04	10	32	2	PF08282
Domain	-	ATP2A1 ATP2A2	3.36e-04	16	32	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2A1 ATP2A2	3.36e-04	16	32	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2A1 ATP2A2	3.81e-04	17	32	2	IPR006068
Domain	Cation_ATPase_C	ATP2A1 ATP2A2	3.81e-04	17	32	2	PF00689
Domain	Cation_ATPase_N	ATP2A1 ATP2A2	4.28e-04	18	32	2	PF00690
Domain	Cation_ATPase_N	ATP2A1 ATP2A2	4.28e-04	18	32	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2A1 ATP2A2	4.78e-04	19	32	2	IPR004014
Domain	SRCR	DMBT1 CD6	5.85e-04	21	32	2	PF00530
Domain	Acetyltransf_1	GNPNAT1 NAT8L	7.04e-04	23	32	2	PF00583
Domain	SR	DMBT1 CD6	8.32e-04	25	32	2	SM00202
Domain	GNAT	GNPNAT1 NAT8L	8.32e-04	25	32	2	PS51186
Domain	GNAT_dom	GNPNAT1 NAT8L	8.32e-04	25	32	2	IPR000182
Domain	-	DMBT1 CD6	8.32e-04	25	32	2	3.10.250.10
Domain	SRCR_1	DMBT1 CD6	9.01e-04	26	32	2	PS00420
Domain	SRCR-like_dom	DMBT1 CD6	9.01e-04	26	32	2	IPR017448
Domain	SRCR_2	DMBT1 CD6	9.01e-04	26	32	2	PS50287
Domain	SRCR	DMBT1 CD6	9.72e-04	27	32	2	IPR001190
Domain	-	ATP2A1 ATP2A2	1.37e-03	32	32	2	2.70.150.10
Domain	-	ATP2A1 ATP2A2	1.37e-03	32	32	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP2A1 ATP2A2	1.63e-03	35	32	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP2A1 ATP2A2	1.73e-03	36	32	2	IPR018303
Domain	P_typ_ATPase	ATP2A1 ATP2A2	1.73e-03	36	32	2	IPR001757
Domain	ATPASE_E1_E2	ATP2A1 ATP2A2	1.73e-03	36	32	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2A1 ATP2A2	1.82e-03	37	32	2	IPR008250
Domain	E1-E2_ATPase	ATP2A1 ATP2A2	1.82e-03	37	32	2	PF00122
Domain	-	GNPNAT1 NAT8L	2.13e-03	40	32	2	3.40.630.30
Domain	BTB-kelch_protein	KLHL35 KLHL34	2.46e-03	43	32	2	IPR017096
Domain	PX	SNX14 SNX33	2.57e-03	44	32	2	SM00312
Domain	fn3	NCAM2 TEK SPEG	2.64e-03	162	32	3	PF00041
Domain	Acyl_CoA_acyltransferase	GNPNAT1 NAT8L	2.69e-03	45	32	2	IPR016181
Domain	PX	SNX14 SNX33	3.18e-03	49	32	2	PF00787
Domain	PX	SNX14 SNX33	3.31e-03	50	32	2	PS50195
Domain	-	SNX14 SNX33	3.44e-03	51	32	2	3.30.1520.10
Domain	Phox	SNX14 SNX33	3.57e-03	52	32	2	IPR001683
Domain	Protein_kinase_ATP_BS	TEK TESK1 CLK2 SPEG	3.83e-03	379	32	4	IPR017441
Domain	FN3	NCAM2 TEK SPEG	3.84e-03	185	32	3	SM00060
Domain	Kelch-typ_b-propeller	KLHL35 KLHL34	3.99e-03	55	32	2	IPR015915
Domain	Ig_I-set	NCAM2 SPEG CADM2	4.14e-03	190	32	3	IPR013098
Domain	I-set	NCAM2 SPEG CADM2	4.14e-03	190	32	3	PF07679
Domain	Kelch	KLHL35 KLHL34	4.43e-03	58	32	2	SM00612
Domain	FN3	NCAM2 TEK SPEG	4.71e-03	199	32	3	PS50853
Domain	BACK	KLHL35 KLHL34	4.73e-03	60	32	2	SM00875
Domain	BACK	KLHL35 KLHL34	4.89e-03	61	32	2	PF07707
Domain	BACK	KLHL35 KLHL34	4.89e-03	61	32	2	IPR011705
Domain	FN3_dom	NCAM2 TEK SPEG	5.39e-03	209	32	3	IPR003961
Domain	Kelch_1	KLHL35 KLHL34	6.39e-03	70	32	2	PF01344
Domain	Kelch_1	KLHL35 KLHL34	6.39e-03	70	32	2	IPR006652
Domain	IGc2	NCAM2 SPEG CADM2	7.45e-03	235	32	3	SM00408
Domain	Ig_sub2	NCAM2 SPEG CADM2	7.45e-03	235	32	3	IPR003598
Domain	PROTEIN_KINASE_ATP	TEK TESK1 CLK2 SPEG	7.51e-03	459	32	4	PS00107
Domain	HAD-like_dom	ATP2A1 ATP2A2	8.07e-03	79	32	2	IPR023214
Domain	-	CHSY1 CHSY3	8.47e-03	81	32	2	3.90.550.10
Domain	Prot_kinase_dom	TEK TESK1 CLK2 SPEG	9.34e-03	489	32	4	IPR000719
Domain	IG_LIKE	NCAM2 TEK SPEG CADM2	9.47e-03	491	32	4	PS50835
Domain	PROTEIN_KINASE_DOM	TEK TESK1 CLK2 SPEG	9.60e-03	493	32	4	PS50011
Domain	Nucleotide-diphossugar_trans	CHSY1 CHSY3	9.93e-03	88	32	2	IPR029044
Domain	Ig-like_dom	NCAM2 TEK SPEG CADM2	1.03e-02	503	32	4	IPR007110
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_SERCA	ATP2A1 ATP2A2	8.40e-05	8	25	2	M47955
Pathway	KEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	8.40e-05	8	25	2	M47920
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2A1 ATP2A2	1.97e-04	12	25	2	M27326
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2A1 ATP2A2	2.71e-04	14	25	2	MM15052
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	FBLIM1 TESK1 CADM2	2.82e-04	73	25	3	MM15126
Pathway	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	FBLIM1 TESK1	4.54e-04	18	25	2	MM15123
Pathway	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	FBLIM1 TESK1	4.54e-04	18	25	2	M840
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	ATP2A1 ATP2A2	4.54e-04	18	25	2	M614
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	5.07e-04	19	25	2	MM14800
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	5.63e-04	20	25	2	M658
Pathway	REACTOME_CELL_CELL_COMMUNICATION	FBLIM1 TESK1 CADM2	6.31e-04	96	25	3	MM14592
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE	CHSY1 CHSY3	6.82e-04	22	25	2	M19166
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2A1 ATP2A2	1.03e-03	27	25	2	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2A1 ATP2A2	1.11e-03	28	25	2	M924
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	FBLIM1 TESK1 CADM2	1.12e-03	117	25	3	M19248
Pathway	WP_MRNA_PROCESSING	NONO CLK2 SMC1A	1.39e-03	126	25	3	M39406
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	CHSY1 CHSY3	2.37e-03	41	25	2	M48095
Pathway	REACTOME_CELL_CELL_COMMUNICATION	FBLIM1 TESK1 CADM2	2.51e-03	155	25	3	M522
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHSY1 CHSY3	3.24e-03	48	25	2	MM14696
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHSY1 CHSY3	3.51e-03	50	25	2	M678
Pathway	REACTOME_ION_HOMEOSTASIS	ATP2A1 ATP2A2	4.08e-03	54	25	2	MM15202
Pathway	REACTOME_ION_HOMEOSTASIS	ATP2A1 ATP2A2	4.08e-03	54	25	2	M27460
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP2A1 ATP2A2	4.23e-03	55	25	2	M971
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	HELZ2 PPARGC1B	4.23e-03	55	25	2	M27145
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP2A1 ATP2A2	4.54e-03	57	25	2	MM15643
Pubmed	Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.	ATP2A1 ATP2A2	9.28e-07	2	34	2	12556521
Pubmed	Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle.	ATP2A1 ATP2A2	9.28e-07	2	34	2	18953100
Pubmed	Chondroitin sulfate synthase-3. Molecular cloning and characterization.	CHSY1 CHSY3	9.28e-07	2	34	2	12907687
Pubmed	SERCA overexpression reduces hydroxyl radical injury in murine myocardium.	ATP2A1 ATP2A2	9.28e-07	2	34	2	16798816
Pubmed	Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest.	ATP2A1 ATP2A2	9.28e-07	2	34	2	19644701
Pubmed	SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain.	ATP2A2 SPEG	9.28e-07	2	34	2	30566039
Pubmed	Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.	ATP2A1 ATP2A2	9.28e-07	2	34	2	14638697
Pubmed	Sarco(endo)plasmic reticulum Ca2+ ATPase isoforms and their role in muscle physiology and pathology.	ATP2A1 ATP2A2	9.28e-07	2	34	2	10603953
Pubmed	Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.	ATP2A1 ATP2A2	9.28e-07	2	34	2	12975374
Pubmed	Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.	ATP2A1 ATP2A2	9.28e-07	2	34	2	15718407
Pubmed	Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight.	ATP2A1 ATP2A2	9.28e-07	2	34	2	34769190
Pubmed	SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis.	ATP2A1 ATP2A2	9.28e-07	2	34	2	11402072
Pubmed	The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.	ATP2A1 ATP2A2	2.78e-06	3	34	2	16410239
Pubmed	Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.	ATP2A1 ATP2A2	2.78e-06	3	34	2	15972723
Pubmed	Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.	CHSY1 CHSY3	2.78e-06	3	34	2	33089528
Pubmed	Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.	ATP2A1 ATP2A2	2.78e-06	3	34	2	27055500
Pubmed	Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression.	ATP2A1 ATP2A2	2.78e-06	3	34	2	16754798
Pubmed	Sarcoplasmic reticulum Ca2+ ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart.	ATP2A1 ATP2A2	2.78e-06	3	34	2	25615793
Pubmed	Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart.	ATP2A1 ATP2A2	2.78e-06	3	34	2	9038922
Pubmed	Specific effects of endurance and sprint training on protein expression of calsequestrin and SERCA in mouse skeletal muscle.	ATP2A1 ATP2A2	2.78e-06	3	34	2	22466636
Pubmed	Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases.	ATP2A1 ATP2A2	2.78e-06	3	34	2	11526231
Pubmed	Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle.	ATP2A1 ATP2A2	5.56e-06	4	34	2	12074580
Pubmed	Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.	ATP2A1 ATP2A2	5.56e-06	4	34	2	9295312
Pubmed	Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).	ATP2A1 ATP2A2	5.56e-06	4	34	2	12032137
Pubmed	Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.	ATP2A1 ATP2A2	5.56e-06	4	34	2	25110346
Pubmed	The nongastric H+-K+-ATPases: molecular and functional properties.	ATP2A1 ATP2A2	5.56e-06	4	34	2	10362770
Pubmed	SERCA1a can functionally substitute for SERCA2a in the heart.	ATP2A1 ATP2A2	5.56e-06	4	34	2	9887021
Pubmed	Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.	CHSY1 CHSY3	5.56e-06	4	34	2	21468578
Pubmed	Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.	ATP2A1 ATP2A2	5.56e-06	4	34	2	10555147
Pubmed	The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.	ATP2A1 ATP2A2	9.26e-06	5	34	2	30299255
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	NCAM2 TEK SPEG CADM2	1.89e-05	162	34	4	25826454
Pubmed	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.	CHSY1 CHSY3	1.94e-05	7	34	2	17145758
Pubmed	Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.	ATP2A1 ATP2A2	1.94e-05	7	34	2	24786561
Pubmed	Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.	ATP2A1 ATP2A2	2.59e-05	8	34	2	27967605
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2A1 ATP2A2	2.59e-05	8	34	2	10951186
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	ATP2A1 ATP2A2	2.59e-05	8	34	2	11784029
Pubmed	Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells.	CHSY1 CHSY3	2.59e-05	8	34	2	6781479
Pubmed	Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.	ATP2A1 ATP2A2	2.59e-05	8	34	2	27923914
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ATP2A1 ATP2A2	2.59e-05	8	34	2	19033399
Pubmed	A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.	ATP2A1 ATP2A2	3.33e-05	9	34	2	25640239
Pubmed	Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.	PPARGC1B ATP2A2	3.33e-05	9	34	2	34029594
Pubmed	The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.	ATP2A1 ATP2A2	3.33e-05	9	34	2	15253893
Pubmed	The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis.	ATP2A1 ATP2A2	5.07e-05	11	34	2	12122109
Pubmed	Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.	CHSY1 CHSY3	6.08e-05	12	34	2	29287114
Pubmed	Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.	CHSY1 CHSY3	6.08e-05	12	34	2	36047655
Pubmed	Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.	CHSY1 GNPNAT1 CHSY3	9.46e-05	90	34	3	30228991
Pubmed	Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.	PPARGC1B ATP2A2	1.10e-04	16	34	2	18628400
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	ATP2A1 ATP2A2	1.25e-04	17	34	2	22411552
Pubmed	Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo.	ATP2A1 ATP2A2	1.41e-04	18	34	2	22522309
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	DMBT1 ATP2A2 NONO SMC1A	1.41e-04	272	34	4	31010829
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	DMBT1 ATP2A1 ATP2A2 NONO	1.64e-04	283	34	4	28533407
Pubmed	Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.	ATP2A1 ATP2A2	1.74e-04	20	34	2	18978355
Pubmed	Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling.	ATP2A1 ATP2A2	2.12e-04	22	34	2	35081489
Pubmed	The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.	ATP2A1 ATP2A2	2.12e-04	22	34	2	28890335
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	CHSY1 CHSY3	2.97e-04	26	34	2	33905568
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP2A1 ATP2A2	3.70e-04	29	34	2	15071553
Pubmed	Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.	TEK ATP2A2	4.24e-04	31	34	2	15843414
Pubmed	Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.	ATP2A1 ATP2A2	4.24e-04	31	34	2	16140986
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HELZ2 CHSY1 SCAF1 DPH2 TESK1 SPEG	6.37e-04	1105	34	6	35748872
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	ATP2A1 ATP2A2	6.38e-04	38	34	2	30786075
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL35 KLHL34	7.43e-04	41	34	2	23676014
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	HELZ2 SCAF1 SNX33 ATP2A2 SMC1A	8.78e-04	774	34	5	15302935
GeneFamily	ATPases Ca2+ transporting	ATP2A1 ATP2A2	7.11e-05	9	26	2	1209
GeneFamily	Beta 4-glycosyltransferases	CHSY1 CHSY3	2.67e-04	17	26	2	425
GeneFamily	GCN5 related N-acetyltransferases	GNPNAT1 NAT8L	5.38e-04	24	26	2	1134
GeneFamily	Beta 3-glycosyltransferases	CHSY1 CHSY3	5.38e-04	24	26	2	426
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NCAM2 SPEG CADM2	1.55e-03	161	26	3	593
GeneFamily	Kelch like\|BTB domain containing	KLHL35 KLHL34	1.65e-03	42	26	2	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL35 KLHL34	1.58e-02	134	26	2	861
GeneFamily	Fibronectin type III domain containing	NCAM2 TEK	2.20e-02	160	26	2	555
Coexpression	HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_4HR	DMBT1 NONO CLK2	1.63e-05	38	34	3	MM653
Coexpression	HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_4HR	DMBT1 NONO CLK2	1.63e-05	38	34	3	M1516
Coexpression	GSE26023_PHD3_KO_VS_WT_NEUTROPHIL_HYPOXIA_DN	KLHL35 NCAM2 TEK ATP2A2	1.18e-04	196	34	4	M8143
Coexpression	GSE22611_NOD2_TRANSD_VS_CTRL_TRANSD_HEK293_MDP_STIM_6H_UP	KLHL35 NCAM2 ATP2A2 NONO	1.20e-04	197	34	4	M8159
Coexpression	GSE26030_UNSTIM_VS_RESTIM_TH17_DAY15_POST_POLARIZATION_DN	NAT8L ATP2A2 NONO CADM2	1.28e-04	200	34	4	M8572
Coexpression	GSE17186_BLOOD_VS_CORD_BLOOD_CD21HIGH_TRANSITIONAL_BCELL_DN	HELZ2 DPH2 PPARGC1B RNASEH2C	1.28e-04	200	34	4	M7186
Coexpression	GSE26351_WNT_VS_BMP_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_DN	NAT8L SNX14 OGFOD3 SLC22A17	1.28e-04	200	34	4	M8480
Disease	Brody myopathy (implicated_via_orthology)	ATP2A1 ATP2A2	3.20e-06	3	31	2	DOID:0050692 (implicated_via_orthology)
Disease	Cannabis use	ATP2A1 CADM2	1.27e-04	16	31	2	EFO_0007585
Disease	congestive heart failure (is_implicated_in)	AGXT2 SMC1A	3.69e-04	27	31	2	DOID:6000 (is_implicated_in)
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	ATP2A1 ATP2A2 SMC1A	4.92e-04	147	31	3	DOID:9352 (biomarker_via_orthology)
Disease	heart disease (implicated_via_orthology)	ATP2A1 ATP2A2	7.33e-04	38	31	2	DOID:114 (implicated_via_orthology)
Disease	obesity (is_implicated_in)	PPARGC1B CADM2	4.13e-03	91	31	2	DOID:9970 (is_implicated_in)
Disease	Eczema	DUSP12 CD6 HSD17B1	4.15e-03	310	31	3	HP_0000964

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFELVRARGGVCIAD	AGXT2	306	Q9BYV1
EGTFGRVVQCVDHRR	CLK2	171	P49760
ERVAGFVRDLGCERV	DPH2	36	Q9BQC3
CRRIGIFGENEEVAD	ATP2A1	636	O14983
ADRCEGQVEVHFRGV	CD6	271	P30203
AEVLARRGEVVAGRF	OGFOD3	71	Q6PK18
GGRRAREVVIEEVAA	KLHL34	286	Q8N239
FGQVERAVVIVDDRG	NONO	171	Q15233
QEDVFRACGVRRLGE	KIF12	76	Q96FN5
AVAICRRIGIFGQDE	ATP2A2	631	P16615
ARERVTEGRVDVLVC	HSD17B1	76	P14061
RVDRSDDGVAVICRV	CADM2	191	Q8N3J6
VAEEVRQAVCEARRG	FBLIM1	26	Q8WUP2
RGRVEDVVVSDECRG	GNPNAT1	116	Q96EK6
ELGRVAGRREDCRAF	HELZ2	1326	Q9BYK8
RLVNGGDRCRGRVEV	DMBT1	1641	Q9UGM3
RCVAFIGQARAEGRA	DUSP12	96	Q9UNI6
RCREVSVEEGRACAV	REM1	201	O75628
ACVFLGVTVDRFGRR	SLC22A17	351	Q8WUG5
GEIEECEVLTRNRRG	PPARGC1B	926	Q86YN6
DEADGIRRRCRVVGF	SNX33	511	Q8WV41
EDVEVGRCVRRFAGV	CHSY1	251	Q86X52
EDVEVGRCVRRFGGT	CHSY3	341	Q70JA7
EGIYRCEGRVEARGE	NCAM2	181	O15394
EKARGRFGVVRACRE	SPEG	2971	Q15772
VFCIDVERNDRRAVG	SNX14	591	Q9Y5W7
RVFVVGTEAEACREG	SCAF1	351	Q9H7N4
VSFRGRCLRGEEVAV	RNASEH2C	61	Q8TDP1
VFEEFCREIGVRNIR	SMC1A	776	Q14683
LRVRGGEDRCSGRVE	SCART1	786	Q4G0T1
CLVRREDRGFTAVVG	TESK1	181	Q15569
FCEGRVRGEAIRIRT	TEK	101	Q02763
ERLGVAGLREACVRF	KLHL35	131	Q6PF15
RGVCIREFRAAEQEA	NAT8L	76	Q8N9F0