Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	monoatomic anion transport	SLC6A1 GABRQ SLC5A8 MTOR SLCO1A2 CLNS1A	2.75e-06	183	45	6	GO:0006820
GeneOntologyBiologicalProcess	inorganic anion transport	SLC6A1 GABRQ SLC5A8 MTOR CLNS1A	4.41e-05	180	45	5	GO:0015698
GeneOntologyBiologicalProcess	microtubule-based process	FER KLHL42 TPR CEP152 XRN2 CEP85 DST DNAH7 CHMP1B IQUB	7.46e-05	1058	45	10	GO:0007017
Domain	SSDP_DNA-bd	SSBP2 SSBP4	1.70e-05	3	45	2	IPR008116
Domain	LisH	SSBP2 SSBP4	2.06e-03	28	45	2	SM00667
Domain	LisH	SSBP2 SSBP4	2.06e-03	28	45	2	IPR006594
Domain	LISH	SSBP2 SSBP4	2.06e-03	28	45	2	PS50896
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP152 DST SIPA1L2 DNAH7 MTOR CEP112 EXPH5 WNK3 DENND4C	1.34e-06	861	45	9	36931259
Pubmed	NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR.	NFAT5 MTOR	1.64e-06	2	45	2	33806698
Pubmed	mTOR regulates the nucleoplasmic diffusion of Xrn2 under conditions of heat stress.	XRN2 MTOR	1.64e-06	2	45	2	25128458
Pubmed	A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity.	SSBP2 SSBP4	4.91e-06	3	45	2	12079286
Pubmed	Association study of frameshift and splice variant polymorphisms with risk of idiopathic recurrent pregnancy loss.	MS4A14 ABCB5	4.91e-06	3	45	2	29956771
Pubmed	Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma.	TPR MTOR	4.91e-06	3	45	2	32207633
Pubmed	Epidermolysis Bullosa Simplex	DST EXPH5	4.56e-05	8	45	2	20301543
Pubmed	Single-stranded DNA binding proteins are required for LIM complexes to induce transcriptionally active chromatin and specify spinal neuronal identities.	SSBP2 SSBP4	8.94e-05	11	45	2	26965372
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	BEND3 CEP152 CEP85 ZNF281	9.54e-05	184	45	4	32908313
Pubmed	Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.	MTOR WNK3	1.07e-04	12	45	2	27782176
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	CEP152 DST SIPA1L2 DENND4C	1.56e-04	209	45	4	36779422
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	TPR XRN2 LINGO2 DST	2.40e-04	234	45	4	36243803
Pubmed	TIF1gamma controls erythroid cell fate by regulating transcription elongation.	SSBP2 SSBP4	2.47e-04	18	45	2	20603019
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	SIPA1L2 IQUB	2.47e-04	18	45	2	20602751
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CEP152 CEP85 DST SIPA1L2 DENND4C	2.72e-04	446	45	5	24255178
Pubmed	Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.	LINGO2 SIPA1L2	3.72e-04	22	45	2	20694011
Pubmed	Human transcription factor protein interaction networks.	BEND3 CEP152 XRN2 SSBP2 CEP85 DST SSBP4 ZNF281	4.42e-04	1429	45	8	35140242
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	CEP85 MTOR	4.82e-04	25	45	2	35211260
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CEP152 DST NFAT5	6.46e-04	130	45	3	12421765
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	SSBP2 SSBP4	6.96e-04	30	45	2	26593974
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	TPR DST CEP112 POLR3A	8.63e-04	329	45	4	34316702
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CEP152 CEP85 CEP112	9.04e-04	146	45	3	21399614
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	BEND3 XRN2 NFAT5 CLNS1A POLR3A	9.14e-04	583	45	5	29844126
Coexpression	GSE9650_NAIVE_VS_EFF_CD8_TCELL_UP	SSBP2 SIPA1L2 ITGAE ZNF281 POLR3A	2.10e-05	200	44	5	M5819
Coexpression	GSE3982_MAST_CELL_VS_TH2_DN	TPR CEP152 ITGAE NFAT5 ZNF281	2.10e-05	200	44	5	M5456
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARD6 CCDC25 SIPA1L2 POLR3A	1.95e-05	158	45	4	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SSBP2 DST CEP112 ABCB5	2.60e-05	170	45	4	6c65ddb496030bb479ef346cc37a9d4dfa6b824f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 CACNG5 SLC5A8 ABCB5	3.39e-05	182	45	4	3d7a8d2ee2137b098248597058974ef5ae09c19e
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEP152 CEP85 DNAH7 CEP112	4.01e-05	190	45	4	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	mLN-ILC\|mLN / Region, Cell class and subclass	SSBP2 DST SIGLEC7 ABCB5	4.80e-05	199	45	4	d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCell	mLN-(3)_ILC\|mLN / shred on region, Cell_type, and subtype	SSBP2 DST SIGLEC7 ABCB5	4.80e-05	199	45	4	00e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TPR DST TRIM14 ZNF281	4.80e-05	199	45	4	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	mLN-(3)_ILC-(30)_ILC\|mLN / shred on region, Cell_type, and subtype	SSBP2 DST SIGLEC7 ABCB5	4.80e-05	199	45	4	33ac6d77099076df01299be429f4ba96f2f34cc1
ToppCell	mLN-ILC-ILC\|mLN / Region, Cell class and subclass	SSBP2 DST SIGLEC7 ABCB5	4.80e-05	199	45	4	ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCell	(3)_ILC\|World / shred on Cell_type and subtype	SSBP2 DST SIGLEC7 ABCB5	4.89e-05	200	45	4	03554b3f323785b1e0b48fa32de0d92065dd798e
ToppCell	Transverse-(3)_ILC-(30)_ILC\|Transverse / shred on region, Cell_type, and subtype	SSBP2 DST SIGLEC7 ABCB5	4.89e-05	200	45	4	528520dc98775aca6cc7568fedf5906ea55e0bea
ToppCell	Transverse-(3)_ILC\|Transverse / shred on region, Cell_type, and subtype	SSBP2 DST SIGLEC7 ABCB5	4.89e-05	200	45	4	c1ad7cb012e1c8911e417f7d64ca662c4f5010e0
ToppCell	Transverse-ILC\|Transverse / Region, Cell class and subclass	SSBP2 DST SIGLEC7 ABCB5	4.89e-05	200	45	4	eb04d6ad2270d3d9ac3d1fae1bb9bedc6fca38fe
ToppCell	Transverse-ILC-ILC\|Transverse / Region, Cell class and subclass	SSBP2 DST SIGLEC7 ABCB5	4.89e-05	200	45	4	60ec185df2f1989bf8febf75b11c46a576829be3
ToppCell	(30)_ILC\|World / shred on Cell_type and subtype	SSBP2 DST SIGLEC7 ABCB5	5.29e-05	204	45	4	bd9fbd278c05e396463704d711b60d47699e3c09
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	FER TPR CEP152 NFAT5 TRIM14 CHMP1B	1.91e-06	194	44	6	4312_DN
Disease	Epidermolysis Bullosa Simplex	DST EXPH5	2.17e-05	5	44	2	C0079298
Disease	epidermolysis bullosa simplex (is_implicated_in)	DST EXPH5	4.54e-05	7	44	2	DOID:4644 (is_implicated_in)
Disease	clinical and behavioural ideal cardiovascular health	LINGO2 NFAT5	5.39e-04	23	44	2	EFO_0007654
Disease	sugar consumption measurement	LINGO2 SSBP4 ZNF281	7.69e-04	120	44	3	EFO_0010158
Disease	Large cell carcinoma of lung	MTOR WNK3	1.05e-03	32	44	2	C0345958
Disease	granulocyte colony-stimulating factor measurement	LINGO2 SLC5A8	1.18e-03	34	44	2	EFO_0008142
Disease	Thyroid carcinoma	TPR MTOR	1.98e-03	44	44	2	C0549473
Disease	serum metabolite measurement	FER CACNG5 LINGO2 C2orf78 SLCO1A2 PKD1L1	2.65e-03	945	44	6	EFO_0005653
Disease	glucose-dependent insulinotropic peptide measurement	CARD6 SLCO1A2	2.85e-03	53	44	2	EFO_0008464

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLSDTEESNMICQTM	CEP152	1616	O94986
DQNTAVSSMSMTAQY	C2orf78	151	A6NCI8
QMESMTYSTERKTNS	ABCB5	631	Q2M3G0
ESEYMAQTQSTNHMI	CEP112	396	Q8N8E3
YMLNTLTSNMSQLHS	BEND3	201	Q5T5X7
DVQTQQMEDTMSSTT	CHMP1B	126	Q7LBR1
NMNQVYSMSSTYIDK	DST	1156	Q03001
VTSIEQISEMNMDYT	GABRQ	91	Q9UN88
TSPLYNMTNMNVATA	LIPJ	291	Q5W064
SATTTLENYLMEMQF	IRGM	96	A1A4Y4
INLTNSGEDSYMTSM	ITGAE	856	P38570
MSVNSDQTLTTENMT	EXPH5	1316	Q8NEV8
MYMTDSNDTISNGTN	LINGO2	516	Q7L985
VYQQTSHMMSALSTN	NFAT5	931	O94916
YSSLMKVENMSSNQD	CCDC25	186	Q86WR0
MLLSMQTQDQSILYA	OR1J4	81	Q8NGS1
EYVMPMNTQLTSEST	CACNG5	76	Q9UF02
MLSQSVSSQYNMAGV	CLNS1A	191	P54105
SDSSLQRQVMSNMYQ	CARD6	386	Q9BX69
ESTVQMNYVSNVSKS	FER	56	P16591
STLNQSAMMETLYSD	CEP85	186	Q6P2H3
TYTQSMNTVLVQEMG	DNAH7	3776	Q8WXX0
SQNTSMSSIYQNCAM	DENND4C	1471	Q5VZ89
TSQDMQSLDMLSQDT	MS4A14	376	Q96JA4
TQMTNIGVYVSNMTD	IQUB	306	Q8NA54
QNSMYMRQLSDLEST	CCDC158	311	Q5M9N0
MSTYKEAETQNTTLN	PKD1L1	366	Q8TDX9
SSDYSTSEMLVNMGN	MTOR	926	P42345
STNSGDNMYTLMNAV	SSBP2	261	P81877
NYSMVNTTNMTSAVV	SLC6A1	176	P30531
SYVTIQNSELMSGSM	POLR3A	636	O14802
YSEMDVMSTATQHQT	SIPA1L2	1421	Q9P2F8
YSLTMQSSVTVQEGM	SIGLEC7	26	Q9Y286
NSTYNETNLMTTTEM	SLC5A8	481	Q8N695
SGSYMNSMLTQIERQ	SLCO1A2	36	P46721
NLTTMYELESSRSMQ	TRAPPC12	696	Q8WVT3
KTSTSNVEQYQAMVT	TPR	956	P12270
DSTNSSENMYTIMNP	SSBP4	281	Q9BWG4
AYEMRMQNNSSPSIS	XRN2	461	Q9H0D6
NINMQSYSVEMPTVS	ZNF281	431	Q9Y2X9
TFESNNEQTIMTMLQ	STAB2	511	Q8WWQ8
LMTEYSQEQLNTMTS	USF3	1291	Q68DE3
YTATEQEMQQQMSLG	TRIM14	181	Q14142
SVAYSSNQTMGSQMV	WNK3	586	Q9BYP7
QSEDMLTVQSYNTVT	KLHL42	411	Q9P2K6