Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN3A

2.84e-0414362GO:0031402
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN3A

9.99e-0426362GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN3A

9.99e-0426362GO:0031420
GeneOntologyMolecularFunctiondynein complex binding

CNTRL NUMA1

1.16e-0328362GO:0070840
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CDK8 MST1R STK36 AK9 MAPKAPK5 POLG CDK19

1.25e-03938367GO:0016772
GeneOntologyMolecularFunctioncyclin-dependent protein serine/threonine kinase activity

CDK8 CDK19

1.33e-0330362GO:0004693
GeneOntologyMolecularFunctioncyclin-dependent protein kinase activity

CDK8 CDK19

1.33e-0330362GO:0097472
GeneOntologyMolecularFunctionkinase activity

CDK8 MST1R STK36 AK9 MAPKAPK5 CDK19

2.25e-03764366GO:0016301
GeneOntologyCellularComponentCKM complex

CDK8 CDK19

3.04e-055372GO:1990508
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN3A

4.08e-0417372GO:0001518
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

CDK8 CDK19

4.58e-0418372GO:0019908
DomainNa_trans_cytopl

SCN1A SCN3A

5.70e-056372PF11933
DomainNa_trans_cytopl

SCN1A SCN3A

5.70e-056372IPR024583
DomainNa_channel_asu

SCN1A SCN3A

1.70e-0410372IPR001696
DomainNa_trans_assoc

SCN1A SCN3A

1.70e-0410372IPR010526
DomainNa_trans_assoc

SCN1A SCN3A

1.70e-0410372PF06512
DomainPROTEIN_KINASE_ATP

CDK8 MST1R STK36 MAPKAPK5 CDK19

2.00e-03459375PS00107
DomainProt_kinase_dom

CDK8 MST1R STK36 MAPKAPK5 CDK19

2.63e-03489375IPR000719
DomainPROTEIN_KINASE_DOM

CDK8 MST1R STK36 MAPKAPK5 CDK19

2.73e-03493375PS50011
DomainKinase-like_dom

CDK8 MST1R STK36 MAPKAPK5 CDK19

4.09e-03542375IPR011009
DomainSer/Thr_kinase_AS

CDK8 STK36 MAPKAPK5 CDK19

5.27e-03357374IPR008271
DomainS_TKc

CDK8 STK36 MAPKAPK5 CDK19

5.38e-03359374SM00220
DomainPROTEIN_KINASE_ST

CDK8 STK36 MAPKAPK5 CDK19

5.53e-03362374PS00108
DomainChannel_four-helix_dom

SCN1A SCN3A

5.69e-0357372IPR027359
Domain-

SCN1A SCN3A

5.69e-03573721.20.120.350
DomainProtein_kinase_ATP_BS

CDK8 MST1R STK36 CDK19

6.50e-03379374IPR017441
DomainPkinase

CDK8 STK36 MAPKAPK5 CDK19

6.62e-03381374PF00069
DomainIQ

SCN1A SCN3A

8.71e-0371372PF00612
DomainIQ

SCN1A SCN3A

1.12e-0281372SM00015
DomainIQ_motif_EF-hand-BS

SCN1A SCN3A

1.37e-0290372IPR000048
DomainIQ

SCN1A SCN3A

1.46e-0293372PS50096
Pubmed

Mediator kinase inhibition further activates super-enhancer-associated genes in AML.

CDK8 CDK19

1.10e-06237226416749
Pubmed

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.

CDK8 CDK19

1.10e-06237232560467
Pubmed

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

CDK8 CDK19

1.10e-06237228855340
Pubmed

Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.

CDK8 CDK19

1.10e-06237235181333
Pubmed

Regulatory functions of the Mediator kinases CDK8 and CDK19.

CDK8 CDK19

1.10e-06237230585107
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

1.10e-06237227690330
Pubmed

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.

CDK8 CDK19

1.10e-06237227678455
Pubmed

HIV Transcription Is Independent of Mediator Kinases.

CDK8 CDK19

1.10e-06237231044597
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

1.10e-06237223965409
Pubmed

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.

CDK8 CDK19

1.10e-06237236006697
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

1.10e-06237224990319
Pubmed

[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].

CDK8 CDK19

1.10e-06237220408451
Pubmed

CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.

CDK8 CDK19

1.10e-06237237378433
Pubmed

Identification of target genes for the CDK subunits of the Mediator complex.

CDK8 CDK19

1.10e-06237222117896
Pubmed

Febrile infection-related epilepsy syndrome (FIRES) is not caused by SCN1A, POLG, PCDH19 mutations or rare copy number variations.

SCN1A POLG

3.30e-06337223066759
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN3A

3.30e-06337212610651
Pubmed

Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.

CDK8 CDK19

3.30e-06337226002960
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A

3.30e-06337233895391
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN3A

3.30e-06337223859570
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN3A

3.30e-06337214973256
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN3A

3.30e-06337218784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN3A

3.30e-06337217544618
Pubmed

Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.

CDK8 CDK19

3.30e-06337228151579
Pubmed

Genetic dissection of susceptibility to audiogenic seizures in inbred mice.

DOCK7 AHR

3.30e-0633722052619
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

3.30e-06337227816501
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN3A

6.60e-06437217537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN3A

6.60e-06437235031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN3A

6.60e-06437229578003
Pubmed

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.

CDK8 CDK19

6.60e-06437229440396
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN3A

6.60e-06437235801810
Pubmed

Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.

CDK8 CDK19

6.60e-06437232439758
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN3A

6.60e-0643728974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN3A

1.10e-0553721679748
Pubmed

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.

CDK8 CDK19

1.10e-05537236545778
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN3A

1.10e-0553728812438
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN3A

1.10e-05537224337656
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN3A

1.65e-05637223652591
Pubmed

The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition.

DOCK7 PPP1R3G

2.30e-05737231553910
Pubmed

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.

CDK8 CDK19

2.30e-05737222668559
Pubmed

A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.

SCRIB DYNC2H1

2.30e-05737215314648
Pubmed

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

CDK8 CDK19

3.07e-05837223749998
Pubmed

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.

CDK8 CDK19

3.07e-05837230695077
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

MST1R MANEA CLSTN3 SCRIB MTDH B3GAT3 MSLN CYP51A1

3.12e-05120137835696571
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN3A

3.95e-05937215746173
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN3A

3.95e-05937216382098
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK7 DISP2 CLSTN3 SCRIB CDK19

6.86e-0540737512693553
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN3A

7.22e-05123728169823
Pubmed

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.

CDK8 CDK19

7.22e-051237223563140
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN3A

7.22e-051237230175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN3A

8.53e-051337215123669
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN3A

1.15e-04153729726281
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

DOCK7 CRNKL1 SRSF11 RPRD2 NUMA1

1.90e-0450637530890647
Pubmed

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.

CRNKL1 OSCP1 SCN1A CYP51A1

3.09e-0430637418973680
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

B3GAT3 TG

3.52e-042637233905568
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

DISP2 MANEA OSCP1 MAPKAPK5 CYP51A1 ISM1

3.78e-0491537632393512
Pubmed

Genetic link between renal birth defects and congenital heart disease.

DYNC2H1 CNTRL

4.09e-042837227002738
Pubmed

Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.

AHR DYNC2H1

4.70e-043037227568566
Pubmed

The DNA sequence and analysis of human chromosome 6.

ARMT1 MANEA AK9 BTN1A1 CDK19

4.89e-0462237514574404
Pubmed

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.

RPRD2 POLG

5.35e-043237226142281
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

DOCK7 CRNKL1 SRSF11 SCRIB MTDH NUMA1

6.84e-04102437624711643
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

SRSF11 RPRD2 MTDH

6.99e-0416337322113938
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

SRSF11 RPRD2 SCRIB NUMA1

8.35e-0439937435987950
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

DOCK7 AHR SCRIB NUMA1

8.43e-0440037435013556
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CDK8 SRSF11 RPRD2 MCTP2 PROM2 POLG CDK19

8.65e-04148937728611215
Pubmed

Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.

SCRIB NUMA1

8.80e-044137234638806
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MST1R STK36 DISP2 MAPKAPK5 PROM2 POLG

1.02e-03110537635748872
Pubmed

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

DOCK7 PSME1 NUMA1

1.02e-0318637314744259
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN3A

5.06e-0592221203
GeneFamilyCyclin dependent kinases

CDK8 CDK19

4.51e-0426222496
GeneFamilyCyclins|Mediator complex

CDK8 CDK19

7.29e-04332221061
ToppCell(08)_PNEC|World / shred by cell type and Timepoint

DISP2 CLSTN3 PROM2 SCN3A

2.06e-051963742ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

AK9 OSCP1 DYNC2H1 CNTRL

2.14e-05198374ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell(09)_Interm._secr.>cil.|World / shred by cell type by condition

AK9 OSCP1 DYNC2H1 CNTRL

2.23e-052003743305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP2 PROM2 ISM1

2.21e-0414237358c2882cb0ede8cc5d84c85a650d28267268e748
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

OSCP1 DYNC2H1 ISM1

3.25e-04162373f0a92c92c3a6cf9fa11fb279a584e7f328cb7d43
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.43e-04165373347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.43e-041653731890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.43e-04165373507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.43e-0416537339a25be081a5d59c7cf107a997d352793d5025fb
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

STK36 RPRD2 NUMA1

3.49e-0416637332d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

AK9 OSCP1 DYNC2H1

3.56e-0416737326cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.68e-04169373f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.75e-0417037335e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellNS-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OSCP1 MSLN ISM1

3.75e-04170373f6a0162bb690dbc19ff1cec64cb933744ad3b496
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.75e-041703730ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCelldroplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP2 CNTRL CYP51A1

3.75e-04170373749144a1a869a6bf9acdd227184319083367dc3f
ToppCelldroplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP2 CNTRL CYP51A1

3.75e-0417037325d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CNTRL SCN3A CYP51A1

3.75e-0417037332917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGS7BP SCN1A SCN3A

3.75e-041703730b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellfacs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP SCN3A TG

3.81e-04171373b54d9d6b03c9c6f28a71cf2ed2bfa9a335bba949
ToppCellfacs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP SCN3A TG

3.81e-041713739d825a2e799421af4f2cf4f4dc8e239b5d00476d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCTP2 CNTRL CYP51A1

3.88e-04172373422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

MST1R PROM2 SCN3A

3.88e-041723730be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCTP2 CNTRL CYP51A1

3.88e-041723731abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCellBL-critical-LOC-Lymphoid-PC|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MANEA BTN1A1 SCN3A

3.94e-0417337390700a876d997f7c0f7b3899dffcda7fdafee547
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STK36 OSCP1 DYNC2H1

3.94e-04173373c3762655caa79ac4879876f470d32578a3c93b01
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

MST1R PROM2 MSLN

4.01e-04174373edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCellHealthy/Control-Plasmablast|Healthy/Control / Disease group and Cell class

MANEA BTN1A1 TG

4.01e-0417437397d19ef3240a1f648c6befaabb9ce45ad469cbce
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

MST1R PROM2 MSLN

4.01e-0417437365539f69100db0b7d90b1b39ee15ab8281f86461
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AK9 OSCP1 DYNC2H1

4.15e-04176373dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DOCK7 AHR DYNC2H1

4.15e-04176373437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCellfacs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN3 RGS7BP SCN3A

4.36e-04179373d76a05f1fee7f2f7b7b7994d3622e96f02b49432
ToppCellfacs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN3 RGS7BP SCN3A

4.36e-041793736be47c877250968a916c711ba0787eb7b4c5443d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DISP2 CLSTN3 SCN1A

4.43e-041803733d54cc767e25d91ed2203d8a03e5bf5e15f21699
ToppCelldroplet-Marrow-BM|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK8 PSME1 STAG3

4.50e-041813734169a1527b9c8f5783b8cc44e3a3924f8ed9a5e2
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_PP_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP MCTP2 SCN3A

4.57e-04182373eb4be1c02b8b033d025e57b8b4cdbfaec4698054
ToppCell5'-Adult-LymphNode-Epithelial-epithelial_progenitor_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DISP2 CDK19 NUMA1

4.57e-04182373cf0a6f99b825eb75f95f376c16a504e2669820ac
ToppCell5'-Adult-LymphNode-Epithelial-epithelial_progenitor_cell-TA|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DISP2 CDK19 NUMA1

4.57e-0418237349e4b362f88d235ed12aabcabb54787c16e32cb7
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM2 BTN1A1 ISM1

4.65e-0418337399ab7a43527eb226027efbcd8c0b6a8e46fc3c93
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM2 BTN1A1 ISM1

4.65e-0418337328916f0597690ff534578be2cb715b485cb1de1a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN3 RGS7BP SCN1A

4.72e-041843737d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AK9 OSCP1 DYNC2H1

4.72e-041843732df903924df9cb71039159416bcbe6a6614e21fe
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK7 MST1R SCN3A

4.79e-0418537338486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK7 MST1R SCN3A

4.79e-041853733c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

AHR MCTP2 SCN1A

4.87e-04186373acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellControl-Epithelial_cells-Tuft-like|Control / group, cell type (main and fine annotations)

PSME1 PROM2 MSLN

4.87e-041863739aaab2e81b7ed6a75ded2c3fb1170590c57b74ba
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPKAPK5 PROM2 MSLN

4.95e-041873735fae538de481367cf6d9a2d52190d77b99f6922c
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPKAPK5 PROM2 MSLN

4.95e-0418737322fd1959879705a8c1128faa9de66696c4e0b7e3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPKAPK5 PROM2 MSLN

4.95e-041873730526c0a818cf28fd5b6ff65fe260e3c3a4a98a2a
ToppCellCerebellum-Neuronal|Cerebellum / BrainAtlas - Mouse McCarroll V32

DISP2 CLSTN3 SCN1A

4.95e-0418737361b9d6eb131a674598aa8409d7fa909c8765442d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN3 RGS7BP SCN1A

5.02e-041883731efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellMS-CD8-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

MANEA MCTP2 INPP5K

5.02e-041883732f0e2c7d79ee2d69a5d908c0247dc950c056c30a
ToppCellfacs-Trachea-3m-Epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PROM2 MSLN TG

5.10e-04189373f8959cc2c14899c8dfeb1b5e51e187537df2f03e
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

AHR PROM2 MSLN

5.10e-04189373f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK7 DYNC2H1 SCN3A

5.10e-041893738ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCellNeuroendocrine-neuroendo-2-Calca|World / Class top

CLSTN3 RGS7BP SCN3A

5.10e-041893736baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK7 DYNC2H1 SCN3A

5.18e-041903734836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

AHR PROM2 MSLN

5.26e-041913733c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellmulticiliated|World / shred by cell class for turbinate

AK9 OSCP1 DYNC2H1

5.34e-041923730f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SCN1A SCN3A CYP51A1

5.34e-041923731d0d6fb89a2b941b7caab2f1f07d6bd5433a11e7
ToppCellNeuroendocrine|World / Class top

CLSTN3 RGS7BP SCN3A

5.34e-041923730199da3ef9ddb6673e9aa41f346f374838aec182
ToppCellfacs-Trachea-nan-3m-Epithelial-mucus_secreting_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK8 PROM2 TG

5.42e-041933733038ed3e53d3367136fac5c9773cd5b7414f49d3
ToppCellfacs-Trachea-3m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDK8 PROM2 TG

5.42e-04193373c5925b3b5d19098e3987789d68a493d7fd548ac9
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PPP1R3G STAG3 ISM1

5.42e-041933732b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCellPND28-Mesenchymal-Mesenchymal_structural|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN3A MSLN ISM1

5.42e-04193373ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCellThalamus-Neuronal|Thalamus / BrainAtlas - Mouse McCarroll V32

DISP2 CLSTN3 B3GAT3

5.42e-04193373712a4acd1167e43543950bc819ff11984e6f718d
ToppCellfacs-Trachea-3m-Epithelial-glandular_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDK8 PROM2 TG

5.42e-041933736905de261d90dfe3dd2c2cf5b2e26afb2bcc3d5b
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PPP1R3G STAG3 ISM1

5.42e-0419337390cfc34c2d0d7c70f071703d35db1d6037961481
ToppCellfacs-Trachea-3m-Epithelial-glandular_epithelial-lung_secretory_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDK8 PROM2 TG

5.42e-04193373f73630725f093c646bdaf178c39505c04a16e2c6
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DISP2 CLSTN3 SCN3A

5.42e-04193373461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DISP2 CLSTN3 SCN3A

5.42e-041933730dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN3A MSLN ISM1

5.42e-0419337330481fb01c7acf85beae10213f038da86bed6777
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

AK9 OSCP1 DYNC2H1

5.51e-041943737a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

AK9 OSCP1 DYNC2H1

5.51e-04194373b4ce60c06568123008b1081d644733cb91c28f51
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical|TCGA-Thryoid / Sample_Type by Project: Shred V9

AHR MST1R MCTP2

5.51e-04194373b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AK9 OSCP1 DYNC2H1

5.59e-0419537393b1559382a12cfb158aa5fac7386e38b4f87989
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDK8 PROM2 TG

5.59e-041953734d7ca21f14730e1b6d0473bc1a11aa626db948f3
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AK9 OSCP1 DYNC2H1

5.59e-041953730e763f36786515698b593e5c93f6a56619c1242d
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-epithelial_cell-epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDK8 PROM2 TG

5.59e-041953738727554ef047ca7f1d4b888a8468f148c64a6918
ToppCelldroplet-Trachea-nan-3m-Epithelial-epithelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK8 PROM2 TG

5.59e-041953739f0ee826d4f0997aee8d63284ed24549bbdf6a28
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AK9 OSCP1 DYNC2H1

5.59e-04195373581b04220587e1d5198b1abd6965965ace7803e7
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM2 BTN1A1 CDK19

5.59e-0419537318220efbd2d6ce6aa7501744fe430b6b46f2fc30
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP SCN3A MSLN

5.59e-041953730bdf845939bc4b8cc94f2808aea60f818425b076
ToppCellfrontal_cortex-Neuronal|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DISP2 CLSTN3 RGS7BP

5.67e-04196373de7d10da862f98894ce47244fbc992f4a12d63bb
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AK9 OSCP1 DYNC2H1

5.76e-041973736865f4831eb23794fb88a8649d48d497bbae3f44
ToppCellsevere-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CDK8 MCTP2 CYP51A1

5.76e-0419737370704b149b2820b8601d2495b7cd9cbe91eda262
ToppCellmoderate-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

AHR MTDH MSLN

5.84e-041983737ecce5e266bb08797088cc8f8309e0c7b48df5c9
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

STK36 AK9 OSCP1

5.84e-041983736d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS7BP SCN1A SCN3A

5.84e-041983734ca5ff320905ab4ff60ed90a5522227c782142a6
Diseasedevelopmental and epileptic encephalopathy 87 (implicated_via_orthology)

CDK8 CDK19

1.53e-062372DOID:0112221 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN3A

6.84e-0510372DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN3A

6.84e-0510372DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN3A

1.00e-0412372DOID:0060170 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN3A

3.48e-0422372DOID:2030 (implicated_via_orthology)
Diseasebitter non-alcoholic beverage consumption measurement

AHR RPRD2

7.41e-0432372EFO_0010093

Protein segments in the cluster

PeptideGeneStartEntry
ASLLPFPQDVINKLD

AHR

51

P35869
LNSLEDLKPFILLND

ARMT1

211

Q9H993
FAVALPLLLDKPNAQ

B3GAT3

256

O94766
PLLLDKPNAQFDSTA

B3GAT3

261

O94766
SLKNLNQFLPELPAD

CNTRL

2171

Q7Z7A1
FARLFNSPLKPLADL

CDK19

176

Q9BWU1
DNTVLLNPPLFALDK

CLSTN3

41

Q9BQT9
LILLQLPKLDSAPFD

BTN1A1

16

Q13410
PRKLLFLSPDLELNS

DISP2

226

A7MBM2
PLPLKNQDDSSLLNL

RGS7BP

221

Q6MZT1
KIALLLDLLQNPNSP

PAAT

411

Q9H8K7
ALPLKQANCLELPLD

MCTP2

441

Q6DN12
PENLLFKDNSLDAPV

MAPKAPK5

151

Q8IW41
LEAANLLLQAQLPPK

POLG

151

P54098
DALPLDLLLFLNPDA

MSLN

116

Q13421
SKASELNLDELPPLN

MANEA

86

Q5SRI9
PLLLPLKDQASQDGF

DYNC2H1

2746

Q8NCM8
FPEDAANQPNLKLLA

CRNKL1

806

Q9BZJ0
FDLKNSLPDALLPNL

DOCK7

196

Q96N67
AAPPLDLSDLLQLNN

INPP5K

26

Q9BT40
PPLTYDQLKDLNLLD

CYP51A1

356

Q16850
PAAAPDDLALLKNLR

MTDH

96

Q86UE4
FARLFNSPLKPLADL

CDK8

176

P49336
PALALPNLANVDLAK

RPRD2

441

Q5VT52
RSFLLDLPNFPDLSK

ISM1

101

B1AKI9
EPALNEANLSNLKAP

PSME1

46

Q06323
LALLNEKQAASPLEP

NUMA1

261

Q14980
LSSEEALKPFLLNPR

AK9

366

Q5TCS8
SLPADPILQAAKFLQ

PPP1R3G

86

B7ZBB8
SKLSDFAAALDPPLL

SCN3A

1811

Q9NY46
LLLDANQLRELPKPF

SCRIB

41

Q14160
IAPNPLAKEELNFLA

OSCP1

286

Q8WVF1
ANLFLDLLGKLLAQP

STK36

561

Q9NRP7
EKLSQFAAALEPPLN

SCN1A

1826

P35498
IPLLPQLLAKFSADA

STAG3

581

Q9UJ98
PDEAKALSLLAPANA

SRSF11

116

Q05519
LNPFPSELVKALLNE

PROM2

76

Q8N271
NQNALKFLASLLELP

TG

561

P01266
QLVLPPNLNDLASLD

MST1R

986

Q04912