Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2 CCNK	5.43e-11	446	61	14	GO:0004674
GeneOntologyMolecularFunction	protein serine kinase activity	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	5.72e-11	363	61	13	GO:0106310
GeneOntologyMolecularFunction	protein kinase activity	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2 CCNK	2.58e-09	600	61	14	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2 CCNK	2.14e-08	709	61	14	GO:0016773
GeneOntologyMolecularFunction	kinase activity	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2 CCNK	5.42e-08	764	61	14	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2 CCNK	6.61e-07	938	61	14	GO:0016772
GeneOntologyMolecularFunction	small GTPase binding	RIMS3 PAK1 PAK3 DAPK3 PKN1 PKN2	4.35e-04	321	61	6	GO:0031267
GeneOntologyMolecularFunction	histone H3 kinase activity	VRK1 PKN1	5.94e-04	12	61	2	GO:0140996
GeneOntologyMolecularFunction	GTPase binding	RIMS3 PAK1 PAK3 DAPK3 PKN1 PKN2	7.93e-04	360	61	6	GO:0051020
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1D ATP5MG SLC13A4 P2RX7 SV2A SLC5A6 SLC6A5 PEX14 ANO5 CACNA1H DISP1	8.00e-04	1180	61	11	GO:0022857
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1D CACNA1H	8.16e-04	14	61	2	GO:0008331
GeneOntologyMolecularFunction	histone deacetylase binding	MAGEA4 MAGEA8 PKN1 PKN2	1.06e-03	147	61	4	GO:0042826
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PKN1 PKN2	1.07e-03	16	61	2	GO:0004697
GeneOntologyMolecularFunction	transporter activity	CACNA1D ATP5MG SLC13A4 P2RX7 SV2A SLC5A6 SLC6A5 PEX14 ANO5 CACNA1H DISP1	1.64e-03	1289	61	11	GO:0005215
GeneOntologyMolecularFunction	protein serine/threonine kinase activator activity	P2RX7 PIM1 CCNK	1.75e-03	78	61	3	GO:0043539
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC13A4 SLC5A6 SLC6A5 CACNA1H	1.85e-03	171	61	4	GO:0015081
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC13A4 SLC5A6 SLC6A5	1.95e-03	81	61	3	GO:0015370
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1D ATP5MG SLC13A4 P2RX7 SLC5A6 SLC6A5 ANO5 CACNA1H	2.73e-03	793	61	8	GO:0015075
GeneOntologyMolecularFunction	calcium/calmodulin-dependent protein kinase activity	CAMK2D DAPK1	3.07e-03	27	61	2	GO:0004683
GeneOntologyMolecularFunction	histone kinase activity	VRK1 PKN1	3.30e-03	28	61	2	GO:0035173
GeneOntologyBiologicalProcess	protein autophosphorylation	VRK1 PIM2 PIM1 CAMK2D DAPK2 PAK1 SIK2 DAPK1 DAPK3	2.22e-08	228	61	9	GO:0046777
GeneOntologyBiologicalProcess	sodium ion transport	SLC13A4 HECW1 P2RX7 CAMK2D SLC5A6 SLC6A5 CACNA1H	1.64e-05	275	61	7	GO:0006814
GeneOntologyBiologicalProcess	gamma-aminobutyric acid secretion	P2RX7 SV2A PAK1	2.71e-05	20	61	3	GO:0014051
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC13A4 HECW1 CAMK2D SLC5A6 SLC6A5 CACNA1H	3.42e-05	208	61	6	GO:0035725
GeneOntologyBiologicalProcess	gamma-aminobutyric acid transport	P2RX7 SV2A PAK1	7.65e-05	28	61	3	GO:0015812
GeneOntologyCellularComponent	cochlear hair cell ribbon synapse	CACNA1D CAMK2D	1.25e-04	6	61	2	GO:0098683
Domain	Ser/Thr_kinase_AS	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	1.05e-10	357	61	13	IPR008271
Domain	S_TKc	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	1.13e-10	359	61	13	SM00220
Domain	PROTEIN_KINASE_ST	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	1.25e-10	362	61	13	PS00108
Domain	Protein_kinase_ATP_BS	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	2.19e-10	379	61	13	IPR017441
Domain	Pkinase	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	2.34e-10	381	61	13	PF00069
Domain	PROTEIN_KINASE_ATP	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	2.26e-09	459	61	13	PS00107
Domain	Prot_kinase_dom	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	4.84e-09	489	61	13	IPR000719
Domain	PROTEIN_KINASE_DOM	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	5.33e-09	493	61	13	PS50011
Domain	Kinase-like_dom	VRK1 PIM2 PIM1 CAMK2D DAPK2 DCLK3 PAK1 SIK2 PAK3 DAPK1 DAPK3 PKN1 PKN2	1.65e-08	542	61	13	IPR011009
Domain	DAPK1	DAPK2 DAPK1 DAPK3	3.31e-08	3	61	3	IPR020676
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	CAMK2D DAPK2 DCLK3 SIK2 DAPK3	3.01e-06	69	61	5	IPR020636
Domain	-	AP1B1 AP2B1	1.05e-05	2	61	2	2.60.40.1150
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	1.05e-05	2	61	2	IPR013037
Domain	DUF2371_TMEM200	TMEM200C TMEM200B	3.14e-05	3	61	2	IPR018787
Domain	PIM1/2/3	PIM2 PIM1	3.14e-05	3	61	2	IPR017348
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	3.14e-05	3	61	2	IPR016342
Domain	B2-adapt-app_C	AP1B1 AP2B1	3.14e-05	3	61	2	PF09066
Domain	DUF2371	TMEM200C TMEM200B	3.14e-05	3	61	2	PF10177
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	6.27e-05	4	61	2	IPR015151
Domain	B2-adapt-app_C	AP1B1 AP2B1	6.27e-05	4	61	2	SM01020
Domain	C2	HECW1 PLCH2 RIMS3 PKN1 PKN2	8.44e-05	137	61	5	SM00239
Domain	C2	HECW1 PLCH2 RIMS3 PKN1 PKN2	1.00e-04	142	61	5	PS50004
Domain	AP_beta	AP1B1 AP2B1	1.04e-04	5	61	2	IPR026739
Domain	-	PKN1 PKN2	1.04e-04	5	61	2	1.10.287.160
Domain	-	HECW1 PLCH2 RIMS3 PKN1 PKN2	1.22e-04	148	61	5	2.60.40.150
Domain	PAK_BD	PAK1 PAK3	1.56e-04	6	61	2	IPR033923
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	1.56e-04	6	61	2	IPR012295
Domain	-	AP1B1 AP2B1	1.56e-04	6	61	2	3.30.310.10
Domain	C2_dom	HECW1 PLCH2 RIMS3 PKN1 PKN2	1.96e-04	164	61	5	IPR000008
Domain	Hr1	PKN1 PKN2	2.18e-04	7	61	2	SM00742
Domain	NXPH/NXPE	NXPE1 NXPE3	2.90e-04	8	61	2	IPR026845
Domain	Coatomer/calthrin_app_sub_C	AP1B1 AP2B1	2.90e-04	8	61	2	IPR009028
Domain	Neurexophilin	NXPE1 NXPE3	2.90e-04	8	61	2	PF06312
Domain	HR1	PKN1 PKN2	2.90e-04	8	61	2	PF02185
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	3.72e-04	9	61	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	3.72e-04	9	61	2	PF02883
Domain	Alpha_adaptinC2	AP1B1 AP2B1	3.72e-04	9	61	2	SM00809
Domain	VDCCAlpha1	CACNA1D CACNA1H	4.64e-04	10	61	2	IPR002077
Domain	-	PAK1 PAK3	6.78e-04	12	61	2	3.90.810.10
Domain	Coatomer/clathrin_app_Ig-like	AP1B1 AP2B1	6.78e-04	12	61	2	IPR013041
Domain	SSD	SCAP DISP1	8.00e-04	13	61	2	IPR000731
Domain	SSD	SCAP DISP1	8.00e-04	13	61	2	PS50156
Domain	Clathrin/coatomer_adapt-like_N	AP1B1 AP2B1	1.07e-03	15	61	2	IPR002553
Domain	Adaptin_N	AP1B1 AP2B1	1.07e-03	15	61	2	PF01602
Domain	PBD	PAK1 PAK3	1.22e-03	16	61	2	SM00285
Domain	PBD	PAK1 PAK3	1.38e-03	17	61	2	PF00786
Domain	CRIB	PAK1 PAK3	1.92e-03	20	61	2	PS50108
Domain	MAGE_N	MAGEA4 MAGEA8	1.92e-03	20	61	2	SM01392
Domain	CRIB_dom	PAK1 PAK3	2.12e-03	21	61	2	IPR000095
Domain	MAGE_N	MAGEA4 MAGEA8	2.32e-03	22	61	2	PF12440
Domain	MAGE_N	MAGEA4 MAGEA8	2.32e-03	22	61	2	IPR021072
Domain	HR1_rho-bd	PKN1 PKN2	3.00e-03	25	61	2	IPR011072
Domain	MAGE	MAGEA4 MAGEA8	5.50e-03	34	61	2	SM01373
Domain	MAGE	MAGEA4 MAGEA8	6.15e-03	36	61	2	PS50838
Domain	MAGE	MAGEA4 MAGEA8	6.15e-03	36	61	2	PF01454
Domain	MHD_dom	MAGEA4 MAGEA8	6.15e-03	36	61	2	IPR002190
Domain	Pkinase_C	PKN1 PKN2	6.49e-03	37	61	2	IPR017892
Pathway	REACTOME_CASPASE_ACTIVATION_VIA_DEPENDENCE_RECEPTORS_IN_THE_ABSENCE_OF_LIGAND	DAPK2 DAPK1 DAPK3	2.91e-06	10	42	3	M866
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_CACNA1D_H_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CACNA1D CAMK2D CACNA1H	4.77e-05	24	42	3	M47509
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KCNJ5_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CACNA1D CAMK2D CACNA1H	5.40e-05	25	42	3	M47510
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP1A1_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CACNA1D CAMK2D CACNA1H	5.40e-05	25	42	3	M47511
Pathway	REACTOME_CASPASE_ACTIVATION_VIA_EXTRINSIC_APOPTOTIC_SIGNALLING_PATHWAY	DAPK2 DAPK1 DAPK3	6.10e-05	26	42	3	M27434
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY	PIM2 PIM1	8.62e-05	5	42	2	M48986
Pathway	REACTOME_CRISTAE_FORMATION	ATP5MG DNAJC11 ATP5MJ	1.26e-04	33	42	3	M27818
Pathway	WP_BLADDER_CANCER	DAPK2 DAPK1 DAPK3	2.25e-04	40	42	3	M39523
Pathway	KEGG_BLADDER_CANCER	DAPK2 DAPK1 DAPK3	2.60e-04	42	42	3	M19096
Pathway	REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	PAK1 PAK3	5.61e-04	12	42	2	M13618
Pathway	REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	PAK1 PAK3	5.61e-04	12	42	2	MM14994
Pathway	REACTOME_ACTIVATION_OF_RAC1	PAK1 PAK3	6.62e-04	13	42	2	M6322
Pathway	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	PAK1 PAK3	7.71e-04	14	42	2	MM15029
Pathway	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	PAK1 PAK3	1.01e-03	16	42	2	M16498
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	PAK1 PAK3	1.15e-03	17	42	2	MM15215
Pathway	REACTOME_EPHRIN_SIGNALING	PAK1 PAK3	1.29e-03	18	42	2	MM15024
Pathway	REACTOME_EPHRIN_SIGNALING	PAK1 PAK3	1.43e-03	19	42	2	M27310
Pathway	REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING	ATP5MG ATP5MJ	1.59e-03	20	42	2	M11716
Pathway	WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA	PIM2 PIM1	1.59e-03	20	42	2	M39381
Pathway	REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS	AP1B1 AP2B1	1.76e-03	21	42	2	M12347
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	PAK1 PAK3	1.76e-03	21	42	2	M27485
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	PAK1 PAK3	1.76e-03	21	42	2	M27494
Pathway	REACTOME_RAC1_GTPASE_CYCLE	PAK1 PAK3 PKN1 PKN2	1.78e-03	175	42	4	MM15599
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1D P2RX7 CAMK2D CACNA1H	1.89e-03	178	42	4	M2890
Pathway	REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING	ATP5MG ATP5MJ	1.93e-03	22	42	2	MM14626
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1D CACNA1H	2.11e-03	23	42	2	M47666
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PKNS	PKN1 PKN2	2.11e-03	23	42	2	MM15216
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	PAK1 PAK3	2.11e-03	23	42	2	MM15222
Pathway	REACTOME_RAC1_GTPASE_CYCLE	PAK1 PAK3 PKN1 PKN2	2.13e-03	184	42	4	M41809
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	CAMK2D PAK1 PAK3	2.19e-03	87	42	3	M12467
Pubmed	The death-associated protein kinases: structure, function, and beyond.	DAPK2 DAPK1 DAPK3	5.66e-09	3	63	3	16756490
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MDN1 HECW1 AP1B1 DSCAM AP2B1 P2RX7 CAMK2D GLUL PAK1 PAK3 DAPK1 DAPK3 PKN1	1.51e-08	963	63	13	28671696
Pubmed	Arabidopsis HY5 protein functions as a DNA-binding tag for purification and functional immobilization of proteins on agarose/DNA microplate.	CAMK2D PAK3 DAPK3	1.60e-06	13	63	3	18082144
Pubmed	Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.	PIM2 PIM1	3.23e-06	2	63	2	9294606
Pubmed	Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.	DSCAM PAK1	3.23e-06	2	63	2	26966010
Pubmed	Ser289 phosphorylation activates both DAPK1 and DAPK2 but in response to different intracellular signaling pathways.	DAPK2 DAPK1	3.23e-06	2	63	2	31116076
Pubmed	The role of PIM1/PIM2 kinases in tumors of the male reproductive system.	PIM2 PIM1	3.23e-06	2	63	2	27901106
Pubmed	Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.	PIM2 PIM1	3.23e-06	2	63	2	19687226
Pubmed	Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells.	DAPK2 DAPK1	3.23e-06	2	63	2	22160140
Pubmed	PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate.	PIM2 PIM1	3.23e-06	2	63	2	17476689
Pubmed	Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.	PAK1 PAK3	3.23e-06	2	63	2	23622267
Pubmed	Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity.	PIM2 PIM1	3.23e-06	2	63	2	15721354
Pubmed	Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.	PAK1 PAK3	3.23e-06	2	63	2	30858169
Pubmed	Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2.	DAPK2 DAPK1	3.23e-06	2	63	2	18535204
Pubmed	Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer.	PKN1 PKN2	3.23e-06	2	63	2	26296974
Pubmed	p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.	PAK1 PAK3	3.23e-06	2	63	2	21115725
Pubmed	DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome.	DSCAM PAK1	3.23e-06	2	63	2	33945512
Pubmed	Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.	PAK1 PAK3	3.23e-06	2	63	2	27474226
Pubmed	Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family.	PKN1 PKN2	3.23e-06	2	63	2	7851406
Pubmed	Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.	PIM2 PIM1	3.23e-06	2	63	2	29665227
Pubmed	Novel roles of PRK1 and PRK2 in cilia and cancer biology.	PKN1 PKN2	3.23e-06	2	63	2	32127582
Pubmed	The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.	PAK1 PAK3	3.23e-06	2	63	2	22815483
Pubmed	The Pim kinases control rapamycin-resistant T cell survival and activation.	PIM2 PIM1	3.23e-06	2	63	2	15642745
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	VRK1 AP1B1 AP2B1 CAMK2D SIK2 PAK3 DAPK3 PKN1 PKN2 CCNK	5.22e-06	910	63	10	36736316
Pubmed	Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.	PKN1 PKN2	9.68e-06	3	63	2	17332740
Pubmed	A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.	PIM2 PIM1	9.68e-06	3	63	2	19965690
Pubmed	Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.	PIM2 PIM1	9.68e-06	3	63	2	10713710
Pubmed	Pim kinase-dependent inhibition of c-Myc degradation.	PIM2 PIM1	9.68e-06	3	63	2	18438430
Pubmed	Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.	PAK1 PAK3	9.68e-06	3	63	2	10075701
Pubmed	Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.	PAK1 PAK3	9.68e-06	3	63	2	15182717
Pubmed	The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.	PAK1 PAK3	9.68e-06	3	63	2	23335370
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1D CACNA1H	9.68e-06	3	63	2	24966091
Pubmed	The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.	PIM2 PIM1	9.68e-06	3	63	2	25238262
Pubmed	Group I Paks as therapeutic targets in NF2-deficient meningioma.	PAK1 PAK3	9.68e-06	3	63	2	25596744
Pubmed	Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.	PIM2 PIM1	9.68e-06	3	63	2	28698206
Pubmed	The essential role of PIM kinases in sarcoma growth and bone invasion.	PIM2 PIM1	9.68e-06	3	63	2	22623646
Pubmed	Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.	PKN1 PKN2	9.68e-06	3	63	2	34499618
Pubmed	Properties of presynaptic P2X7-like receptors at the neuromuscular junction.	P2RX7 SV2A	9.68e-06	3	63	2	15713258
Pubmed	Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.	PIM2 PIM1	9.68e-06	3	63	2	7781606
Pubmed	Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.	PIM2 PIM1	9.68e-06	3	63	2	24916111
Pubmed	Pim serine/threonine kinases regulate the stability of Socs-1 protein.	PIM2 PIM1	9.68e-06	3	63	2	11854514
Pubmed	Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.	PIM2 PIM1	9.68e-06	3	63	2	23360755
Pubmed	Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28.	PIM2 PIM1	9.68e-06	3	63	2	35326457
Pubmed	PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.	PIM2 PIM1	9.68e-06	3	63	2	29781812
Pubmed	The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.	PAK1 PAK3	9.68e-06	3	63	2	18507705
Pubmed	Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.	PKN1 PKN2	9.68e-06	3	63	2	9446575
Pubmed	Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.	PIM2 PIM1	9.68e-06	3	63	2	15705789
Pubmed	Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.	PIM2 PIM1	9.68e-06	3	63	2	23495171
Pubmed	Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.	PIM2 PIM1	9.68e-06	3	63	2	18042805
Pubmed	PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.	PKN1 PKN2	9.68e-06	3	63	2	35730579
Pubmed	Patterns and Significance of PIM Kinases in Urothelial Carcinoma.	PIM2 PIM1	9.68e-06	3	63	2	26551340
Pubmed	Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.	PKN1 PKN2	9.68e-06	3	63	2	21754995
Pubmed	The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.	PKN1 PKN2	9.68e-06	3	63	2	27569559
Pubmed	Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.	PAK1 PAK3	9.68e-06	3	63	2	38785043
Pubmed	Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.	PIM2 PIM1	9.68e-06	3	63	2	22080570
Pubmed	PIM kinases: an overview in tumors and recent advances in pancreatic cancer.	PIM2 PIM1	9.68e-06	3	63	2	24799066
Pubmed	Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.	PIM2 PIM1	9.68e-06	3	63	2	23209281
Pubmed	DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.	DAPK2 DAPK1	9.68e-06	3	63	2	11980920
Pubmed	The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.	PAK1 PAK3	9.68e-06	3	63	2	9823899
Pubmed	Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.	PIM2 PIM1	9.68e-06	3	63	2	15199164
Pubmed	Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.	PKN1 PKN2	9.68e-06	3	63	2	27919031
Pubmed	PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.	PAK1 PAK3	9.68e-06	3	63	2	29860311
Pubmed	PIM kinases as therapeutic targets against advanced melanoma.	PIM2 PIM1	9.68e-06	3	63	2	27448973
Pubmed	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.	PAK1 PAK3	9.68e-06	3	63	2	11278486
Pubmed	Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.	PIM2 PIM1	9.68e-06	3	63	2	20939820
Pubmed	Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.	PIM2 PIM1	9.68e-06	3	63	2	21859846
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	AGAP5 AP1B1 AP2B1 CAMK2D GLUL PKN2	1.22e-05	281	63	6	28706196
Pubmed	Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.	AP1B1 AP2B1 PAK1	1.27e-05	25	63	3	20594957
Pubmed	Structure--function relationships in HIV-1 Nef.	AP1B1 AP2B1 PAK1	1.61e-05	27	63	3	11463741
Pubmed	eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes.	PIM2 PIM1	1.93e-05	4	63	2	23749639
Pubmed	Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.	AP1B1 AP2B1	1.93e-05	4	63	2	17290217
Pubmed	RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.	PIM2 PIM1	1.93e-05	4	63	2	22201128
Pubmed	The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.	PIM2 PIM1	1.93e-05	4	63	2	18216297
Pubmed	Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2.	PIM2 PIM1	1.93e-05	4	63	2	8622900
Pubmed	Identification of multiple, novel, protein kinase C-related gene products.	PKN1 PKN2	1.93e-05	4	63	2	7988719
Pubmed	PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.	PAK1 PAK3	1.93e-05	4	63	2	9659915
Pubmed	Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.	PKN1 PKN2	1.93e-05	4	63	2	25513777
Pubmed	A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.	PAK1 PAK3	1.93e-05	4	63	2	7493928
Pubmed	Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.	DAPK2 DAPK1	1.93e-05	4	63	2	10629061
Pubmed	PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression.	PIM2 PIM1	1.93e-05	4	63	2	32878131
Pubmed	Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.	PKN1 PKN2	1.93e-05	4	63	2	10753910
Pubmed	Pak to the future.	PAK1 PAK3	1.93e-05	4	63	2	10461188
Pubmed	PIM kinases 1, 2 and 3 in intracellular LIF signaling, proliferation and apoptosis in trophoblastic cells.	PIM2 PIM1	1.93e-05	4	63	2	28729093
Pubmed	A brain serine/threonine protein kinase activated by Cdc42 and Rac1.	PAK1 PAK3	1.93e-05	4	63	2	8107774
Pubmed	Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.	PKN1 PKN2	1.93e-05	4	63	2	31564129
Pubmed	Fast Ca2+ Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca2+ Waves of Inner Supporting Cells in the Developing Mouse Cochlea.	CACNA1D P2RX7	1.93e-05	4	63	2	30104958
Pubmed	Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.	PKN1 PKN2	1.93e-05	4	63	2	23223530
Pubmed	Identification and characterization of collaborating oncogenes in compound mutant mice.	PIM2 PIM1	1.93e-05	4	63	2	10197595
Pubmed	CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.	PAK1 PAK3	1.93e-05	4	63	2	19819308
Pubmed	ATM binds to beta-adaptin in cytoplasmic vesicles.	AP1B1 AP2B1	1.93e-05	4	63	2	9707615
Pubmed	Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.	AP1B1 AP2B1	1.93e-05	4	63	2	7534311
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	ATP5MG VRK1 AP1B1 AP2B1 DNAJC11 TM9SF3	2.67e-05	323	63	6	24797263
Pubmed	DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.	DAPK1 DAPK3	3.22e-05	5	63	2	18995835
Pubmed	Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.	PKN1 PKN2	3.22e-05	5	63	2	20188095
Pubmed	The Pim protein kinases regulate energy metabolism and cell growth.	PIM2 PIM1	3.22e-05	5	63	2	21187426
Pubmed	Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells.	DIS3L XRN1	3.22e-05	5	63	2	20368444
Pubmed	Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.	PAK1 PAK3	3.22e-05	5	63	2	23509247
Pubmed	Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.	PIM2 PIM1	3.22e-05	5	63	2	16403219
Pubmed	Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma.	PAK1 PKN1	3.22e-05	5	63	2	9533029
Pubmed	Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.	PKN1 PKN2	3.22e-05	5	63	2	12783890
Cytoband	2p23	SLC5A6 GCKR	2.49e-04	17	63	2	2p23
Cytoband	1p36.22	VPS13D PEX14	1.20e-03	37	63	2	1p36.22
Cytoband	15q22.31	DIS3L DAPK2	1.54e-03	42	63	2	15q22.31
Cytoband	14q32	VRK1 CCNK	2.92e-03	58	63	2	14q32
Cytoband	11p15.1	SLC6A5 TMEM86A	3.12e-03	60	63	2	11p15.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q23	ATP5MG SIK2 NXPE1	3.49e-03	220	63	3	chr11q23
GeneFamily	Ankyrin repeat domain containing\|Death associated protein kinases	DAPK2 DAPK1 DAPK3	6.63e-08	5	35	3	1021
GeneFamily	C2 domain containing protein kinases	PKN1 PKN2	1.62e-04	10	35	2	835
GeneFamily	Calcium voltage-gated channel subunits	CACNA1D CACNA1H	1.15e-03	26	35	2	253
GeneFamily	MAGE family	MAGEA4 MAGEA8	2.71e-03	40	35	2	1136
GeneFamily	AAA ATPases	MDN1 WRNIP1	4.72e-03	53	35	2	413
GeneFamily	Ankyrin repeat domain containing	AGAP5 DAPK1 ANKRD16	1.13e-02	242	35	3	403
Coexpression	GSE7219_WT_VS_NIK_NFKB2_KO_LPS_AND_ANTI_CD40_STIM_DC_DN	CACNA1D DAPK2 RIMS3 IRF4 GBA2 DISP1	8.66e-06	200	63	6	M386
ToppCell	Leuk-UTI-Myeloid-tDC\|Leuk-UTI / Disease, Lineage and Cell Type	TMEM182 SLC13A4 SV2A DAPK2 RIMS3	3.28e-06	161	63	5	51b9f60986ed2e8e2297d31c80462c3ab65a2e5e
ToppCell	facs-Aorta-Heart-24m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 PIM2 PIM1 RIMS3 IRF4	3.92e-06	167	63	5	b85fd7ab21c80470bca804c788ce49a2bce763f8
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D MMS22L PIM2 IRF4 NXPE3	4.53e-06	172	63	5	2dcc9d67d6ecc35940eabbc8ed528f5f884f6976
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D MMS22L PIM2 IRF4 NXPE3	4.53e-06	172	63	5	64d2edbd8e2640b76225597883b1a524e6b1dd3b
ToppCell	facs-Heart-RV-18m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D MMS22L PIM2 IRF4 NXPE3	4.53e-06	172	63	5	d061ea21bee179df5a525842e9a48621a8e1461b
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MTMR7 OLFM3 SLC6A5 ANO5 CACNA1H	6.62e-06	186	63	5	2fab7abed16a894afdd0207e86fc43a25a77fb9e
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MTMR7 OLFM3 SLC6A5 ANO5 CACNA1H	6.62e-06	186	63	5	ea2c8e0df038a00062d2098b4a9ac85141b9a728
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MTMR7 OLFM3 SLC6A5 ANO5 CACNA1H	6.62e-06	186	63	5	714765585a644bf9817ab6eb3001b43b3c2d2410
ToppCell	Sepsis-Leuk-UTI-Myeloid-tDC\|Leuk-UTI / Disease, condition lineage and cell class	TMEM182 SLC13A4 SV2A DAPK2 RIMS3	9.19e-06	199	63	5	a2f154b15087803958a656d2a41b6d83fd37b32f
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VRK1 SLC13A4 PAK1 IRF4	5.76e-05	148	63	4	31a7c2b20970070b14d2b955020320a6f99db547
ToppCell	mild_COVID-19_(asymptomatic)-NK_CD56bright\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TMEM182 PIM2 HECW1 SIK2	6.23e-05	151	63	4	2470162f4b56bc505db166a6eb0fa54847759df8
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VRK1 SLC13A4 PAK1 IRF4	6.39e-05	152	63	4	27718e92715ddc80f28b457a5d6d6a3ac2b205d2
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-7\|TCGA-Liver / Sample_Type by Project: Shred V9	FBXO31 SLC5A6 GLUL DISP1	7.61e-05	159	63	4	70288df54adab167c0f50675128619299077db11
ToppCell	droplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDN1 PAK1 DAPK1 IRF4	8.18e-05	162	63	4	8a488ecd25ef41468c3c7766eb936dbc2f7665a9
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tfh\|GI_large-bowel / Manually curated celltypes from each tissue	SETD1B SLC5A6 ANO5 CACNA1H	8.37e-05	163	63	4	4104d3b9748b39cb0744c9be76db21bdda566a0d
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 PAK1 DAPK1 TMEM200B	8.78e-05	165	63	4	479962ce1c3d6636ae62b6709635299748653801
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 PIM1 PAK1 IRF4	9.20e-05	167	63	4	fd84a99ea142d1684cdcf4a88ef1d541760bc78a
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PIM2 XRN1 IRF4 NXPE3	9.41e-05	168	63	4	f5a18123f84c62211d9279e9c41e90122e4c4895
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIM2 PIM1 IRF4 CACNA1H	9.41e-05	168	63	4	bc7d5f0e5d222922eaf1c8e8c87aab189209d6b6
ToppCell	droplet-Lung-nan-21m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 PIM1 PAK1 IRF4	9.85e-05	170	63	4	71c52fadecc6b4bfe98692b266adaa1406f6d56d
ToppCell	droplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 PIM1 PAK1 IRF4	9.85e-05	170	63	4	d72eb77271d61e27a3d247149561c7f45fadb28b
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 PIM1 PAK1 IRF4	9.85e-05	170	63	4	6686d1797988216c0d9417f21a2537369abce410
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 PIM1 PAK1 IRF4	1.01e-04	171	63	4	7c4362eeacbe52d7f4fdf93c841d7b59526328c1
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 PAK1 DAPK1 IRF4	1.03e-04	172	63	4	cabe7b4131d72da87d3caacd8cced3a4f2cbef53
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PIM2 XRN1 IRF4 NXPE3	1.10e-04	175	63	4	6a093c74a6f3daeff07759d6eec542fc5c709149
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 PAK1 DAPK1 IRF4	1.13e-04	176	63	4	a85ad8b4815fde72edd5c900e882a0bc04033ea8
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-CD45____plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIM2 PIM1 IRF4 CACNA1H	1.15e-04	177	63	4	41cbb2c109eaa7be366fc0510cce64abc06837b4
ToppCell	facs-Lung-EPCAM-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 PIM1 PAK1 IRF4	1.15e-04	177	63	4	e73e2b6a72630bb56ac2af1cdeedc8f0f828f390
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 PIM1 PAK1 IRF4	1.20e-04	179	63	4	55fde77dae7f9e7f3431c3185d14212a25af83df
ToppCell	COPD-Epithelial-PNEC\|Epithelial / Disease state, Lineage and Cell class	SLC6A5 PAK3 ANO5 CACNA1H	1.20e-04	179	63	4	988d0853c391da1e5004f73f3678047418d3f6d3
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIM2 PIM1 IRF4 CACNA1H	1.34e-04	184	63	4	82d2daa39e3c31a74c08a5d77366740b87beb2fb
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PIM2 XRN1 IRF4 NXPE3	1.36e-04	185	63	4	3b77bc49cd3740acc025e162a36282ac09e12198
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CACNA1D FBXO31 DAPK1 CACNA1H	1.36e-04	185	63	4	1d874608aa2062024323512f68889219471b2f00
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 RIMS3 PAK1	1.39e-04	186	63	4	bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 DSCAM PAK1	1.39e-04	186	63	4	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|lung / Disease (COVID-19 only), tissue and cell type	VRK1 PIM2 IRF4 NXPE3	1.39e-04	186	63	4	66676d9395172de5707e204826a1c9f73b448cca
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MTMR7 OLFM3 PAK3 ANO5	1.39e-04	186	63	4	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 RIMS3 PAK1	1.42e-04	187	63	4	f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell	367C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLC13A4 PIM2 CAMK2D PAK3	1.42e-04	187	63	4	3748203b62abf51b74dfcfc4f18b3ba831b63a96
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	VRK1 PIM2 IRF4 NXPE3	1.45e-04	188	63	4	567b08514d9d84cbb40f9b7a679eec304f023428
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 RIMS3 PAK1	1.48e-04	189	63	4	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AP1B1 TM9SF3 GLUL ATP5MJ	1.51e-04	190	63	4	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 DSCAM PAK1	1.51e-04	190	63	4	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 DSCAM PAK1	1.51e-04	190	63	4	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	(3)_MNP-(3)_DC_1\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	SLC13A4 PIM2 CAMK2D PAK3	1.54e-04	191	63	4	cf0ea54670ed478c3302ccfbee9f6b6706e49fcd
ToppCell	PBMC-Control-cDC_4\|Control / Compartment, Disease Groups and Clusters	ATP5MG PAK1 PKN2 ATP5MJ	1.57e-04	192	63	4	385061d6257295bd515dea98f9bcd52374509276
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 DSCAM PAK1	1.57e-04	192	63	4	5c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MTMR7 DSCAM PAK3 CACNA1H	1.67e-04	195	63	4	5f33ece997f074598b4201ff74f592ee07c86a06
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OLFM3 HECW1 DSCAM PAK1	1.67e-04	195	63	4	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DAPK2 THSD7B TMEM200B NXPE3	1.74e-04	197	63	4	d7cef7881abd807a679432766ced609a6efd1067
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DAPK2 THSD7B TMEM200B NXPE3	1.74e-04	197	63	4	20a5958512bdb99daeb8f4d244df53e4f048f879
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1D HECW1 PAK1 PAK3	1.77e-04	198	63	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PIM2 PIM1 IRF4 NXPE3	1.80e-04	199	63	4	1bb02f41f3cc76a28581e38b0ca4c36b930b85b4
ToppCell	mild-Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HECW1 GLUL PAK1 PKN2	1.80e-04	199	63	4	ca319976a7d2576186d0a98cdc93e4c2d5fe8a05
ToppCell	Sigmoid-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	SCAP FBXO31 CAMK2D PAK3	1.84e-04	200	63	4	09deb831fc2c8a8867cc850f3aa094a5e48489ff
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	VPS13D SETD1B HECW1 DAPK2 DAPK3 IRF4 CCNK	1.04e-06	196	62	7	3837_UP
Drug	15d-PGJ2; Up 200; 10uM; PC3; HT_HG-U133A	VPS13D HECW1 PIM1 WRNIP1 IRF4 CCNK	1.05e-05	183	62	6	4455_UP
Drug	2-Aminobenzenesulfonamide [3306-62-5]; Down 200; 23.2uM; MCF7; HT_HG-U133A	CACNA1D VPS13D RIMS3 PEX14 CCNK NXPE3	1.38e-05	192	62	6	3400_DN
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	CACNA1D VPS13D PIM2 P2RX7 DAPK3 CACNA1H	1.46e-05	194	62	6	3422_UP
Disease	Adenocarcinoma of large intestine	PIM1 DCLK3 PAK3 DAPK3 PKN1	1.69e-06	96	61	5	C1319315
Disease	feeling nervous measurement	TMEM182 MMS22L DSCAM IRF4	3.24e-05	87	61	4	EFO_0009597
Disease	Failure to Thrive	AP1B1 SLC5A6	6.27e-05	6	61	2	C0015544
Disease	infant expressive language ability	DSCAM DAPK3	4.95e-04	16	61	2	EFO_0006316
Disease	Infiltrating duct carcinoma of female breast	DCLK3 PKN1	8.61e-04	21	61	2	C3165106
Disease	BMI-adjusted fasting blood glucose measurement	LRRC37A5P GCKR	1.03e-03	23	61	2	EFO_0008036
Disease	obsolete Mendelian syndromes with cleft lip/palate	PAK1 PKN1	1.03e-03	23	61	2	MONDO_0015335
Disease	facial width measurement	DAPK1 THSD7B DISP1	1.36e-03	105	61	3	EFO_0007855
Disease	diet measurement	TMEM182 MMS22L DSCAM SIK2 CACNA1H ATP5MJ GCKR THSD7B	1.38e-03	1049	61	8	EFO_0008111
Disease	cardiovascular age measurement	AGAP5 CAMK2D	1.65e-03	29	61	2	EFO_0803380
Disease	endometrial carcinoma	MDN1 PAK1 PKN1	1.67e-03	113	61	3	EFO_1001512
Disease	pyridoxate measurement	CACNA1D THSD7B	1.88e-03	31	61	2	EFO_0010527
Disease	triacylglycerol 54:5 measurement	MMS22L GCKR	2.00e-03	32	61	2	EFO_0010423

Protein segments in the cluster

Peptide	Gene	Start	Entry
YEPLGLEADMWSIGV	DAPK1	191	P53355
AAMIWIVGEYAERID	AP2B1	446	P63010
SIGVWQDILYGMAVL	ANO5	726	Q75V66
DVLAYLAEAWGMDIE	ANKRD16	51	Q6P6B7
WEPEIIAVAVMYLAG	CCNK	201	O75909
AAMIWIVGEYAERID	AP1B1	446	Q10567
NGLVATEVLMWFYVG	ATP5MG	76	O75964
YAALIADWPVVVLGM	DISP1	181	Q96F81
DELWVVMEYLAGGSL	PAK3	351	O75914
EESRMGLIIVNAWYG	DNAJC11	456	Q9NVH1
VNAIYGLMVALLIWG	OR52N4	196	Q8NGI2
AATMGHWILLEDIDY	MDN1	391	Q9NU22
EIWEELGVMGVYDGR	MAGEA4	221	P43358
EEAIWEALSVMGLYD	MAGEA8	221	P43361
LERGVVLWMAPDGLY	IRF4	311	Q15306
LEEMLQYLLIDWIVG	LRRC37A5P	6	Q49AS3
GWVLIDLSEEYTRMG	MTMR7	126	Q9Y216
DIHWLVLEILYMLGE	MMS22L	216	Q6ZRQ5
VDAGDWIGMYLIDEV	HECW1	106	Q76N89
GLEVDMWAAGVILYI	DCLK3	531	Q9C098
NVVVDGLFIIGWMYL	FBXO31	161	Q5XUX0
LELVAGLPEGYMFIW	FKBP9P1	46	Q75LS8
YEPLGLEADMWSIGV	DAPK3	191	O43293
YLVGWQTLGIIAIMD	GCKR	331	Q14397
LDSYLVGDELWVVME	PAK1	331	Q13153
VGDELWVVMEYLAGG	PAK1	336	Q13153
WVVMEYLAGGSLTDV	PAK1	341	Q13153
AIQGGIMGIEIYWDC	P2RX7	246	Q99572
WVGVVYGLAATMIQE	GBA2	821	Q9HCG7
YEPLGLEADMWSIGV	DAPK2	201	Q9UIK4
LGGVDRYAVSIMWEL	DIS3L	551	Q8TF46
YQEIWIGMGLMGFIV	ATP5MJ	21	P56378
WVNIMYDGLDAVGVD	CACNA1H	1506	O95180
TMPWEIVILVGGGYA	SLC13A4	461	Q9UKG4
MAGTVVWIGILVYTD	SCAP	521	Q12770
ILTGEDWNAVMYDGI	CACNA1D	701	Q01668
DIDLMADEIGLWAVY	OLFM3	346	Q96PB7
DMWACGVILYILLVG	CAMK2D	196	Q13557
VGIIDAWDMTIAYGT	NXPE1	511	Q8N323
WSLGILLYDMVCGDI	PIM1	226	P11309
VIYWANLMDGELGEI	DSCAM	1126	O60469
VQAMYIWIDGTGEGL	GLUL	26	P15104
LVVLVGMGIAVAGYW	TMEM200B	61	Q69YZ2
LVLLVGIAMAVVGYW	TMEM200C	61	A6NKL6
ILSMVGYAVGLGNVW	SLC6A5	201	Q9Y345
VGVYLVDAWEMTLAH	NXPE3	516	Q969Y0
VLQVIVWGDYGRMDH	RIMS3	236	Q9UJD0
AVVGLLAGLVMAFWI	SLC5A6	456	Q9Y289
VWSLGILLYDMVCGD	PIM2	221	Q9P1W9
WSMGVVLYVLVCGAL	SIK2	201	Q9H0K1
EEMTILYDIWNGGID	SETD1B	1676	Q9UPS6
VDWWGLGVLLYEMLV	PKN1	796	Q16512
WGLGVLIYEMLVGES	PKN2	841	Q16513
WRDYGALAIIMAGIA	PEX14	106	O75381
MIGGVYAAAMAWAII	SV2A	301	Q7L0J3
QLLIWYGVDVMARDA	AGAP5	641	A6NIR3
LVGVYVALIGFMGWR	TMEM86A	146	Q8N2M4
WVTGLRYLMAGISDE	PLCH2	146	O75038
ERIIDDWILMGFLVG	XRN1	276	Q8IZH2
RGDLEILGYCMIQWL	VRK1	241	Q99986
QMYIDDLPIWGIVGE	TM9SF3	131	Q9HD45
WLARMLEGGEDPLYV	WRNIP1	521	Q96S55
IWVYGVSGGAFLIMI	THSD7B	1556	Q9C0I4
IYRGFWAVLMLLGVV	TMEM182	111	Q6ZP80
MLEGLVAWVLNTYLG	VPS13D	1	Q5THJ4