Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC13A5 MFSD12 SLC4A9 SLC7A3

7.19e-05293164GO:0008514
GeneOntologyMolecularFunctionsymporter activity

SLC13A5 MFSD12 SLC4A9

2.17e-04150163GO:0015293
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC13A5 MFSD12 SLC7A3

5.57e-04207163GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC13A5 MFSD12 SLC7A3

5.64e-04208163GO:0005342
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC13A5 MFSD12 SLC4A9

1.56e-03296163GO:0015291
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC13A5 SLC4A9

1.88e-0381162GO:0015370
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

MFSD12 SLC7A3

1.97e-0383162GO:0015101
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

MFSD12 SLC7A3

3.13e-03105162GO:0015171
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC13A5 SLC4A9

4.00e-03119162GO:0015294
GeneOntologyMolecularFunctionATP hydrolysis activity

NLRP1 IDE HELB

4.84e-03441163GO:0016887
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC13A5 MFSD12 SLC4A9

6.02e-03477163GO:0022804
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC13A5 SLC4A9

8.09e-03171162GO:0015081
GeneOntologyMolecularFunctionATP-dependent activity

NLRP1 IDE HELB

1.20e-02614163GO:0140657
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC13A5 MFSD12 SLC4A9 SLC7A3

1.25e-021180164GO:0022857
DomainLRRCT

LRIG2 LRIG3

3.36e-0432162PF01463
DomainLRR

LRIG2 LRIG3 NLRP1

6.20e-04201163PS51450
DomainLRR_1

LRIG2 LRIG3 NLRP1

7.96e-04219163PF00560
DomainLeu-rich_rpt

LRIG2 LRIG3 NLRP1

1.47e-03271163IPR001611
Domain-

LRIG2 LRIG3 NLRP1

2.39e-033211633.80.10.10
DomainL_dom-like

LRIG2 LRIG3 NLRP1

2.54e-03328163IPR032675
DomainCys-rich_flank_reg_C

LRIG2 LRIG3

2.64e-0390162IPR000483
DomainLRRCT

LRIG2 LRIG3

2.64e-0390162SM00082
DomainLRR_8

LRIG2 LRIG3

9.19e-03171162PF13855
DomainLeu-rich_rpt_typical-subtyp

LRIG2 LRIG3

9.82e-03177162IPR003591
DomainLRR_TYP

LRIG2 LRIG3

9.82e-03177162SM00369
DomainI-set

LRIG2 LRIG3

1.12e-02190162PF07679
DomainIg_I-set

LRIG2 LRIG3

1.12e-02190162IPR013098
DomainIg_sub2

LRIG2 LRIG3

1.68e-02235162IPR003598
DomainIGc2

LRIG2 LRIG3

1.68e-02235162SM00408
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC13A5 SLC4A9 SLC7A3

5.22e-04238103MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC13A5 SLC4A9 SLC7A3

5.96e-04249103M5988
Pubmed

The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea.

LRIG2 LRIG3

1.98e-07216215203213
Pubmed

Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma.

LRIG2 LRIG3

1.98e-07216234839782
Pubmed

Down-regulation of leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) in HP75 pituitary adenoma cell line.

LRIG2 LRIG3

1.98e-07216217393120
Pubmed

Redistribution of LRIG proteins in psoriasis.

LRIG2 LRIG3

5.95e-07316218037903
Pubmed

LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers.

LRIG2 LRIG3

5.95e-07316227628597
Pubmed

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.

LRIG2 LRIG3

5.95e-07316233469151
Pubmed

A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.

LRIG2 LRIG3

4.16e-06716220446891
Pubmed

In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.

LRIG2 LRIG3

5.55e-06816224086156
Pubmed

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

LRIG2 LRIG3

5.55e-06816226651291
Pubmed

Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.

LRIG2 LRIG3

1.10e-043416218848646
InteractionSPSB2 interactions

LRIG2 DOCK5 LRIG3

6.80e-0651153int:SPSB2
InteractionGALP interactions

B4GALT6 IDE

1.08e-057152int:GALP
InteractionSPSB4 interactions

LRIG2 DOCK5 LRIG3

9.80e-05124153int:SPSB4
CytobandEnsembl 112 genes in cytogenetic band chr18q12

B4GALT6 GAREM1

5.97e-04104162chr18q12
CytobandEnsembl 112 genes in cytogenetic band chr12q14

LRIG3 HELB

7.29e-04115162chr12q14
CytobandEnsembl 112 genes in cytogenetic band chr17p13

SLC13A5 NLRP1

6.34e-03346162chr17p13
GeneFamilySolute carriers

SLC13A5 SLC4A9 SLC7A3

7.88e-0439593752
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRIG2 LRIG3

2.72e-0316192593
ToppCellsystemic_lupus_erythematosus-treated-Hematopoietic-Progen-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TUT4 SLC7A3 C12orf57

2.91e-0517116361d622153b91702ef21b0efc7b9581e592b7ccea
ToppCellsystemic_lupus_erythematosus-treated-Hematopoietic-Progen|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TUT4 SLC7A3 C12orf57

2.91e-0517116309b3fa120f63c411f8a0dd6bd230a9720ce83fb1
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

LRIG3 RIMS1 GAREM1

3.92e-0518916384d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TUT4 HELB C12orf57

4.05e-05191163d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LRIG2 RIMS1 HELB

4.64e-0520016361bae10c8b12196d9cee766897971b81cb897191
Drugbutylbenzyl

NLRP1 C12orf57

1.29e-058162CID000007705
DrugAC1L89QG

NLRP1 B4GALT6 RIMS1

1.39e-0568163CID000323970
Drugembutramide

NLRP1 IDE

3.60e-0513162CID000027453
DiseaseTNF-related apoptosis-inducing ligand measurement

B4GALT6 GAREM1

6.89e-0472162EFO_0008300
Diseasemean fractional anisotropy measurement

DOCK5 SLC4A9

1.20e-0395162EFO_0008399
Diseaseattempted suicide

RIMS1 IDE

4.11e-03178162EFO_0004321
Diseaseuterine fibroid

DOCK5 SLC7A3

5.10e-03199162EFO_0000731
Diseasenicotine dependence symptom count

B4GALT6 RIMS1

1.02e-02285162EFO_0009262

Protein segments in the cluster

PeptideGeneStartEntry
IFLAPVLKFIPMPVL

SLC4A9

826

Q96Q91
AIPPKMFKLPQLQHL

LRIG3

206

Q6UXM1
HVNLPPLEFKPALML

KIAA1109

2501

Q2LD37
LEMKFQFVRIHKPPP

NLRP1

1266

Q9C000
KILPMHFPLHLTVPK

GAREM1

291

Q9H706
LVRHYKTLPPKMPLL

RIMS1

1041

Q86UR5
PHKIKFIPSMVGPIL

DOCK5

1096

Q9H7D0
LPIFFLHLIPMLQKQ

B4GALT6

171

Q9UBX8
GLPLFPLVKPHINFM

IDE

1001

P14735
PLLLLPLVILMPAKF

SLC13A5

21

Q86YT5
LHLPKKFIATIPLVM

MFSD12

306

Q6NUT3
KLKALFLPPMTLPPH

C12orf57

101

Q99622
PLHFKVPALPLLPLM

SLC7A3

536

Q8WY07
KIMEFLPVLLPRHFK

HELB

216

Q8NG08
PKVFLHQKPRLPKLF

CNBD1

71

Q8NA66
DIKFPPKMNHPDLLI

TUT4

416

Q5TAX3
MIPPKIFKLPHLQFL

LRIG2

206

O94898