Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium channel activity

TRPM1 TPCN2 TRPM3 TRPM7

2.23e-05129264GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPM1 TPCN2 TRPM3 TRPM7

4.13e-05151264GO:0015085
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7

1.26e-04627266GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7

1.72e-04664266GO:0008324
GeneOntologyMolecularFunctionolfactory receptor activity

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

2.07e-04431265GO:0004984
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A6 TRPM1 TPCN2 TRPM3 TRPM7

2.94e-04465265GO:0046873
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7

3.52e-04758266GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7

4.48e-04793266GO:0015075
GeneOntologyMolecularFunctionchannel activity

SLC12A6 TRPM1 TPCN2 TRPM3 TRPM7

5.13e-04525265GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC12A6 TRPM1 TPCN2 TRPM3 TRPM7

5.18e-04526265GO:0022803
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7 DISP1

6.02e-041180267GO:0022857
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2L2 OR1K1 OR2T12 OR2Z1 GPR22 OR2T33

7.95e-04884266GO:0004930
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPM1 TPCN2 TRPM3 TRPM7

9.49e-04343264GO:0005261
GeneOntologyMolecularFunctiontransporter activity

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7 DISP1

1.02e-031289267GO:0005215
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH10 PAFAH1B1

1.06e-0337262GO:0045505
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TRPM1 TPCN2 TRPM3 TRPM7

2.76e-03459264GO:0005216
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR2L2 OR1K1 OR2T12 OR2Z1 GPR22 OR2T33

6.80e-031353266GO:0004888
GeneOntologyMolecularFunctionphosphoprotein binding

PAFAH1B1 SH2D3C

1.01e-02117262GO:0051219
GeneOntologyMolecularFunctionprotein serine kinase activity

CDK9 TRPM7 CSNK2A2

1.14e-02363263GO:0106310
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7 TMEM74

1.24e-04942267GO:0098655
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

1.80e-04432265GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

2.53e-04465265GO:0007608
GeneOntologyBiologicalProcesssensory perception

OR2L2 OR1K1 TRPM1 OR2T12 OR2Z1 OR2T33 RBP3

2.76e-041072267GO:0007600
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

3.08e-04485265GO:0050907
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7 TMEM74

3.51e-041115267GO:0034220
GeneOntologyBiologicalProcessprotein tetramerization

TRPM1 TRPM3 TRPM7

3.80e-04113263GO:0051262
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

4.39e-04524265GO:0009593
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7 TMEM74

4.40e-041157267GO:0006812
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

5.34e-04547265GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

7.07e-04582265GO:0050906
DomainTRPM_tetra

TRPM1 TRPM3 TRPM7

8.47e-094253PF16519
DomainTRPM_tetra

TRPM1 TRPM3 TRPM7

8.47e-094253IPR032415
DomainIon_trans_dom

TRPM1 TPCN2 TRPM3 TRPM7

1.51e-05114254IPR005821
DomainIon_trans

TRPM1 TPCN2 TRPM3 TRPM7

1.51e-05114254PF00520
DomainOlfact_rcpt

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

1.51e-04393255IPR000725
DomainGPCR_Rhodpsn_7TM

OR2L2 OR1K1 OR2T12 OR2Z1 GPR22 OR2T33

2.06e-04670256IPR017452
Domain7tm_1

OR2L2 OR1K1 OR2T12 OR2Z1 GPR22 OR2T33

2.18e-04677256PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2L2 OR1K1 OR2T12 OR2Z1 GPR22 OR2T33

2.32e-04685256PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2L2 OR1K1 OR2T12 OR2Z1 GPR22 OR2T33

2.43e-04691256PS50262
DomainGPCR_Rhodpsn

OR2L2 OR1K1 OR2T12 OR2Z1 GPR22 OR2T33

2.45e-04692256IPR000276
PathwayREACTOME_TRP_CHANNELS

TRPM1 TRPM3 TRPM7

1.38e-0528243MM14943
PathwayREACTOME_TRP_CHANNELS

TRPM1 TRPM3 TRPM7

1.38e-0528243M27241
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM1 TPCN2 TRPM3 TRPM7

2.18e-0599244MM14910
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM1 TPCN2 TRPM3 TRPM7

2.86e-05106244M27200
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM1 TPCN2 TRPM3 TRPM7

2.05e-04176244MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM1 TPCN2 TRPM3 TRPM7

2.38e-04183244M997
PathwayBIOCARTA_LIS1_PATHWAY

CSNK2A2 PAFAH1B1

2.50e-0414242MM1531
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION

CSNK2A2 SEC11A

3.29e-0416242M48235
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

4.30e-04389245M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33 RBP3

5.52e-04636246M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2L2 OR1K1 OR2T12 OR2Z1 OR2T33

5.90e-04417245M4072
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7

7.92e-04681246MM14985
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC12A6 SLC47A1 TRPM1 TPCN2 TRPM3 TRPM7

1.19e-03736246M27287
Pubmed

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.

TRPM1 TRPM3 TRPM7

8.12e-081226319850157
Pubmed

Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.

TRPM1 TRPM3

5.37e-07226221278253
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM1 TRPM3 TRPM7

7.43e-072426333884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM1 TRPM3 TRPM7

8.44e-072526316382100
Pubmed

An introduction to TRP channels.

TRPM1 TRPM3 TRPM7

1.07e-062726316460286
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM1 TRPM3 TRPM7

1.99e-063326319834762
Pubmed

Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.

TRPM1 TRPM3

3.22e-06426222211741
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPM1 TRPM3 TRPM7

4.81e-064426319322198
Pubmed

Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.

TRPM1 TRPM7

5.37e-06526216857711
Pubmed

The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.

CDK9 CSNK2A2

2.41e-051026212591939
Pubmed

MicroRNA profile of the developing mouse retina.

TRPM1 TRPM3

4.86e-051426219933188
Pubmed

Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.

TRPM3 TRPM7

8.16e-051826231911949
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR2L2 OR2T12 OR2Z1 OR2T33

1.13e-0434026411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR2L2 OR2T12 OR2Z1 OR2T33

1.13e-0434026411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR2L2 OR2T12 OR2Z1 OR2T33

1.17e-0434326432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR2L2 OR2T12 OR2Z1 OR2T33

1.21e-0434626414611657
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CDK9 DNAH10 TRPM3 CSNK2A2 PAFAH1B1

1.83e-0473026534857952
Pubmed

Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.

OR1K1 SH2D3C

2.31e-043026220583170
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

SLC47A1 GPR22 TRPM3

5.23e-0421226319521566
Pubmed

The human olfactory receptor gene family.

OR2L2 OR2T12 OR2Z1 OR2T33

6.60e-0454126414983052
InteractionOR2T12 interactions

OR2T12 OR2T33

1.25e-062232int:OR2T12
InteractionOR2T33 interactions

OR2T12 OR2T33

3.74e-063232int:OR2T33
InteractionTTYH1 interactions

SLC12A6 SLC47A1 TPCN2 TRPM7 SEC11A

1.91e-05300235int:TTYH1
InteractionTRPM6 interactions

TRPM3 TRPM7

3.47e-058232int:TRPM6
InteractionNKAIN1 interactions

SLC12A6 SLC47A1 TRPM7

5.42e-0565233int:NKAIN1
InteractionACP2 interactions

TPCN2 CSNK2A2 TMEM74

1.12e-0483233int:ACP2
InteractionH3-4 interactions

TRPM1 DNAH10 TRPM7 SEC11A PAFAH1B1

1.28e-04448235int:H3-4
InteractionZACN interactions

SLC47A1 TRPM7 SEC11A

1.73e-0496233int:ZACN
InteractionOR2G6 interactions

SLC12A6 SLC47A1

1.89e-0418232int:OR2G6
Cytoband1q44

OR2L2 OR2T12 OR2T33

3.34e-051102631q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2L2 OR2T12 OR2T33

5.25e-05128263chr1q44
CytobandEnsembl 112 genes in cytogenetic band chr9q34

CDK9 SH2D3C

1.45e-02325262chr9q34
GeneFamilyTransient receptor potential cation channels

TRPM1 TRPM3 TRPM7

2.67e-0628183249
GeneFamilyOlfactory receptors, family 2

OR2L2 OR2T12 OR2Z1 OR2T33

4.14e-06113184149
CoexpressionGAO_STOMACH_24W_C4_PARIETAL_PROGENITOR

CCDC80 H6PD

2.44e-058252M39142
Drug3-deazacytidine

CDK9 SLC12A6 PTDSS2 CSNK2A2 PAFAH1B1

2.65e-06206255CID000001652
DiseaseMASA syndrome (implicated_via_orthology)

TRPM1 TRPM3 TRPM7

1.65e-087243DOID:0060246 (implicated_via_orthology)
Diseasehip circumference

H6PD DNAH10 TRPM7

2.52e-03338243EFO_0005093
Diseasesunburn

TRPM1 TPCN2

2.76e-0396242EFO_0003958
Diseasefacial width measurement

TRPM1 DISP1

3.29e-03105242EFO_0007855
Diseasebrain aneurysm

SLC47A1 CCDC80

3.80e-03113242EFO_0003870
Diseasegluteofemoral adipose tissue measurement

H6PD DNAH10

5.14e-03132242EFO_0803317
Diseasediabetic nephropathy

CCDC80 SH2D3C

6.58e-03150242EFO_0000401

Protein segments in the cluster

PeptideGeneStartEntry
TQLGTFMMLIMCISW

DISP1

1106

Q96F81
MTWRMGPRFTMLLAM

CCDC80

1

Q76M96
SKRVCVMMITGSWMI

OR2L2

136

Q8NH16
KMWDVSTGMCLMTLV

PAFAH1B1

321

P43034
MVRSVAWAGFMVLLM

CHIT1

1

Q13231
PTLMSWQLCLRMTMS

OR2T12

131

Q8NG77
VCLRMMAMSWLSGVI

OR14L1P

141

Q8NHC6
MRRQVCLLMMGSSWV

OR2Z1

136

Q8NG97
PTLMSWQLCLRMTMS

OR2T33

131

Q8NG76
RMSRAMCAALVGMAW

OR1K1

136

Q8NGR3
MWSLGCMLASMIFRR

CSNK2A2

216

P19784
ILTMGRAVMLMISIW

GPR22

151

Q99680
MWNMLIVAMCLALLG

H6PD

1

O95479
GCIMAEMWTRSPIMQ

CDK9

216

P50750
LDTIPAMMSALRMVW

DNAH10

361

Q8IVF4
WALSFMGMSICLALM

SLC12A6

681

Q9UHW9
MGMSICLALMFISSW

SLC12A6

686

Q9UHW9
LKTLMIRDWWMCMII

PTDSS2

206

Q9BVG9
RLAIPSMLMLCMEWW

SLC47A1

261

Q96FL8
MLFWVISMVMVAVGV

TSPAN33

31

Q86UF1
MMREWVLLMSVLLCG

RBP3

1

P10745
TCSQMLLTDMWMGRL

TRPM3

776

Q9HCF6
GMIVSSALMIWKGLM

SEC11A

26

P67812
HTCSQMLLTDMWMGR

TRPM1

726

Q7Z4N2
MQTLMGVRWGMELLT

SH2D3C

611

Q8N5H7
LGGVILSCLLMMSMW

TMEM74

241

Q96NL1
HTCTQMLLSDMWMGR

TRPM7

736

Q96QT4
GLLSLWDMTRMLNML

TPCN2

536

Q8NHX9